Researchers Database

HAYANO Junichiro

    Graduate School of Medical Sciences Department of Medical Education Professor
Last Updated :2021/06/11

Researcher Information


  • MD(1988/11 Nagoya City University)
  • PhD(Nagoya City University Graduate School of Medical Sciences)


J-Global ID

Research Interests

  • 情動   居眠り   生体情報   時系列解析   健康科学   情報科学   sleep apnea   biosignal processing   big data   heart rate variability   

Research Areas

  • Informatics / Biological, health, and medical informatics
  • Life sciences / Cardiology
  • Life sciences / Biomaterials
  • Life sciences / Biomedical engineering

Association Memberships

  • JAPAN SOCIETY OF PHYSIOLOGICAL ANTHROPOLOGY   日本内科学会   日本心身医会学会   日本生体医工学会   The Japanese Circulation Society   

Published Papers

Books etc

  • Big data technologies and applications
    Emi Yuda; Yuki Furukawa; Yutaka Yoshida; Junichiro Hayano (Joint workALLSTAR Project Investigators. Association between regional difference in heart rate variability and inter-prefecture ranking of healthy life expectancy: ALLSTAR big data project in Japan)Springer Nature 2017
  • Clinical assessment of the autonomic nervous system
    Junichiro Hayano (Joint editorIntroduction to heart rate variability)Springer Nature 2016
  • 9. 循環器疾患と自律神経機能
    早野 順一郎 (Joint work心拍変動による自律神経解析)医学書院 2001

Conference Activities & Talks

  • Junichiro Hayano; Emi Yuda; Yutaka Yoshida
    2017 IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2017  2017/07 
    © 2017 IEEE. This paper presents the performance of sleep stage classification by combination of actigraphic and heart rate signals. We studied 40,643 epochs (length 3 min) of polysomnographic data in 289 subjects. Body movement indices derived from actigraphic data and autonomic functional indices from heart rate variability were useful for discriminating between non-REM sleep and waking/REM sleep at 76.9% sensitivity and 74.5% specificity and between REM sleep and waking at 77.2% sensitivity and 72.3% specificity.
  • Yutaka Tsujimoto; Yuki Miki; Eiichi Watanabe; Junichiro Hayano; Yoshiharu Yamamoto; Taishin Nomura; Ken Kiyono
    2017 International Conference on Noise and Fluctuations, ICNF 2017  2017/07 
    © 2017 IEEE. To evaluate long-range cross-correlated behavior observed in bivariate time series, detrended cross-correlation analysis (DCCA) was proposed. In the DCCA, trends embedded in each time series are eliminated via piecewise least-squares polynomial fitting in the same way as the detrended fluctuation analysis (DFA). In this paper, as an improved variant of DCCA, we propose a DCCA method using the Savitzky-Golay detrending filters and its fast implementation algorithm. In addition, as an application of our method, we analyze the cardiorespiratory interaction.
  • Junichiro Hayano; Yutaka Yoshida; Emi Yuda
    ACM International Conference Proceeding Series  2017/05 
    Vast heart rate (HR) data during daily activities are being accumulated with widespread use of wearable sensors. To interpret the meaning of these HR data, the reference point of HR in individual subject is required. Although resting HR has been used for this purpose, the definition of resting HR has not been established and particularly, the effects of time of the day (circadian rhythm) on resting HR have not been considered. One of the other candidates for the reference point may be basal HR, i.e., the lowest HR in the day. In the present study, we therefore investigated the characteristics of basal HR by examining the effects of age and sex on basal HR and the occurrence time of basal HR during 24 h in 113,341 males and 140,332 females extracted from a 24-h Holter ECG database of the Allostatic State Mapping by Ambulatory ECG Repository (ALLSTAR). Although basal HR decreases with age until 20 yr old in both sexes, it increases slightly with advancing age thereafter. Although the clock time to reach basal HR appears between 02 and 05 h on average, it shows progress or delay depending on the time of life. The difference between 24-h mean and basal HR decrease linearly with age, suggesting that age-dependent decline in the increases in HR with daily activities can be detected by using basal HR as the reference point.
  • Zbigniew R. Struzik; Ken Kiyono; Junichiro Hayano; Seiichiro Sakata; Shin Kwak; Yoshiharu Yamamoto
    AIP Conference Proceedings  2005/08 
    Methodologies originally developed in the field of statistical physics of complex phenomena have been proven to provide new insights into the modeling, description and understanding of the human heart rate regulatory system. Recent studies have shown the heart rate control system to maintain universality properties characteristic of physical systems exhibiting far-from-equilibrium, critical state-like dynamics. Simultaneously, heart rate regulation has been shown to display correlation properties of antagonist dynamics involving antagonist actors, pertinent to some far-from-equilibrium systems. We discuss the range of validity and breakdown scenarios of the universal properties in heart rate regulation leading to the diagnostic capability and also to new challenges for both analysis methods and up-to-date simulation models. © 2005 American Institute of Physics.
  • Stefan Heinrichs; Zbigniew; R. Struzik; Zbigniew; R. Struzik; Junichiro Hayano; Yoshiharu Yamamoto; Yoshiharu Yamamoto
    Proceedings of SPIE - The International Society for Optical Engineering  2004/09 
    Using the method of local Continuous Detrended Fluctuation Analysis (CDFA) we analyze the correlations of ventricular interbeat intervals of patients with Atrial Fibrillation (AF). CDFA yields a local Holder exponent h for a neighborhood around each point in the time series by determining the scaling of fluctuations with window size after detrending. We compare the histograms of Hölder exponents for original data with those of randomly shuffled data and find some correlations not only in long-range windows but also at short time scales where interbeat intervals during AF have been believed to be random in nature. Furthermore, we find unique temporal correlation structures to occur only in the heart rate of patients who were in the survivor group when a follow up was conducted at least one year after data acquisition. We conclude that ventricular interbeat intervals during AF contain richer information than previously considered and the study of the local correlations may be useful in predicting mortality of the patients.
  • Zbigniew R. Struzik; Zbigniew; R. Struzik; Junichiro Hayano; Seiichiro Sakata; Shin Kwak; Yoshiharu Yamamoto; Yoshiharu Yamamoto
    Proceedings of SPIE - The International Society for Optical Engineering  2004/09 
    We present the first systematic evidence for the origins and breakdown of I/f scaling in human heart rate. We confirm a previously posed conjecture that I/f scaling in heart rate is caused by the intricate balance between antagonistic activity of sympathetic (SNS) and parasympathetic (PNS) nervous systems. We demonstrate that modifying the relative importance of either of the two branches leads to a substantial decrease of I/f scaling. In particular, the relative PNS suppression both by congestive heart failure (CHF) and by the parasympathetic blocker atropine results in a substantial increase in the Hurst exponent H and a shift of the multifractal spectrum f(α) from 1/f towards random walk scaling 1/f2. Surprisingly, we observe a similar breakdown in the case of relative and neurogenic SNS suppression by primary autonomic failure (PAF). Further, we observe an intriguing interaction between multifractality of heart rate and absolute variability. While it is generally believed that lower absolute variability results in monofractal behaviour, as has been demonstrated both for CHF and the parasympathetic blockade, in PAF patients we observe conservation of multifractal properties at substantially reduced absolute variability to levels closer to CHF. This novel and intriguing result leads us to the conjecture that the multifractality of the heart rate can be traced back to the intrinsic dynamics of the parasympathetic nervous system.
  • Hiroshi Hayashi; Junichiro Hayano
    Clinical and Experimental Hypertension  2003/04
  • Reiko Ikeuchi; Nagahiko Sakuma; Takeshi Hibino; Takaaki Sato; Yoshinobu Kamiya; Masanobu Kawaguchi; Nobuyuki Ohte; Junichiro Hayano
    Current Therapeutic Research  1994/01 
    The effects of bezafibrate on lipid metabolism were evaluated in 22 patients with type IIb or type IV hypertriglyceridemia. Bezafibrate 400 mg/d was administered for 8 weeks. A fat emulsion tolerance test (FETT) to evaluate serum triglyceride (TG) clearance (fractional removal rate = K2) and measurement of cholesteryl ester transfer protein (CETP) activity were performed before bezafibrate administration and after the 8-week treatment period using blood samples obtained after overnight fasting. Statistically significant reductions were observed in serum TG (P < 0.01), apolipoprotein (apo) B (P < 0.01), apo C-II (P < 0.05), apo C-III (P < 0.001), and apo E (P < 0.05). Significant increases were seen in high-density lipoprotein cholesterol (HDL-C) (P < 0.001), apo A-I (P < 0.001), and apo A-II (P < 0.001). K2was significantly elevated (P < 0.001). CETP activity declined slightly, but the change was not statistically significant. Strong positive correlations were evident between the absolute value of increased K2and the increase in both HDL-C (r = .67, P < 0.005) and apo A-I (r = .53, P < 0.05). It can be inferred from these findings that the bezafibrate-induced reduction in serum TG and increase in HDL-C observed in patients with hypertriglyceridemia arise from an acceleration in TG-rich lipoprotein metabolism. © 1994 Excerpta Medica, Inc. All rights reserved.


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Awards & Honors

  • 2017 第37回ホルター・ノンインベーシブ研究会 優秀演題賞
    受賞者: 早野 順一郎
  • 1990 日本心電学会 第6回木村栄一賞
    受賞者: 早野 順一郎

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