Researcher Database


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HAYANO Junichiro

FacultyGraduate School of Medical Sciences Department of Medical Education
PositionProfessor
Mailhayanomed.nagoya-cu.ac.jp
HomepageURLhttp://hbsl.jp/
Birthday
Last Updated :2018/10/08

Researcher Profile and Settings

Degree

  • MD, Nagoya City University
  • PhD, Nagoya City University Graduate School of Medical Sciences

Association Memberships

  • JAPAN SOCIETY OF PHYSIOLOGICAL ANTHROPOLOGY

Research Activities

Research Areas

  • Informatics, Life/Health/Medical informatics
  • Clinical internal medicine, Cardiovascular medicine
  • Biomedical engineering, Biomedical engineering/Biomaterial science and engineering

Research Interests

    sleep apnea, biosignal processing, big data, heart rate variability

Published Papers

  • Evaluation of nocturnal heart rate variability for strenuous exercise day using wearable photoelectric pulse wave sensor., Yoshida Y, Yuda E, Yokoyama K, Hayano J, Journal of exercise rehabilitation, 14, (4) 633 - 637, 08 , Refereed
  • Impacts of sleeping time during the day on the timing and level of basal heart rate: analysis of ALLSTAR big data, Yuda E, Yoshida Y, Hayano J, Wireless Networks, 06 , Refereed
  • Scattering Transform of Heart Rate Variability for the Prediction of Ischemic Stroke in Patients with Atrial Fibrillation., Leonarduzzi R, Abry P, Wendt H, Kiyono K, Yamamoto Y, Watanabe E, Hayano J, Methods of information in medicine, 57, (3) 141 - 145, 05 , Refereed
  • Increase in random component of heart rate variability coinciding with developmental and degenerative stages of life., Hayano J, Ohashi K, Yoshida Y, Yuda E, Nakamura T, Kiyono K, Yamamoto Y, Physiological measurement, 39, (5) , 05 , Refereed
  • Acute effects of endurance exercise on nocturnal autonomic functions in sedentary subjects: a pilot study., Yuda E, Moriyama Y, Mori T, Yoshida Y, Kawahara M, Hayano J, Journal of exercise rehabilitation, 14, (1) 113 - 117, 02 , Refereed
  • Sleep stage classification by a combination of actigraphic and heart rate signals, Emi Yuda, Yutaka Yoshida, Ryujiro Sasanabe, Haruhito Tanaka, Toshiaki Shiomi, Junichiro Hayano, Journal of Low Power Electronics and Applications, 7, 12 01 , © 2017 by the authors. Licensee MDPI, Basel, Switzerland. Although heart rate variability and actigraphic data have been used for sleep-wake or sleep stage classifications, there are few studies on the combined use of them. Recent wearable sensors, however, equip both pulse wave and actigraphic sensors. This paper presents results on the performance of sleep stage classification by a combination of heart rate and actigraphic signals. We studied 40,643 epochs (length 3 min) of polysomnographic data in 289 subjects. A combined model, consisting of autonomic functional indices from heart rate variability and body movement indices derived from actigraphic data, discriminated non-rapid-eye-movement (REM) sleep from waking/REM sleep with 76.9% sensitivity, 74.5% specificity, 75.8% accuracy, and a Cohen’s kappa of 0.514. The combination was also useful for discriminating between REM sleep and waking at 77.2% sensitivity, 72.3% specificity, 74.5% accuracy, and a kappa of 0.491.
  • Exposure to blue light during lunch break: effects on autonomic arousal and behavioral alertness., Yuda E, Ogasawara H, Yoshida Y, Hayano J, Journal of physiological anthropology, 36, (1) , 07 11 , Refereed
  • Sodium balance, circadian BP rhythm, heart rate variability, and intrarenal renin-angiotensin-aldosterone and dopaminergic systems in acute phase of ARB therapy., Isobe-Sasaki Y, Fukuda M, Ogiyama Y, Sato R, Miura T, Fuwa D, Mizuno M, Matsuoka T, Shibata H, Ito H, Ono M, Abe-Dohmae S, Kiyono K, Yamamoto Y, Kobori H, Michikawa M, Hayano J, Ohte N, Physiological reports, 5, (11) , 06 , Refereed
  • Prognostic Importance of Novel Oxygen Desaturation Metrics in Patients With Heart Failure and Central Sleep Apnea., Watanabe E, Kiyono K, Matsui S, Somers VK, Sano K, Hayano J, Ichikawa T, Kawai M, Harada M, Ozaki Y, Journal of cardiac failure, 23, (2) 131 - 137, 02 , Refereed
  • Enhancement of autonomic and psychomotor arousal by exposures to blue wavelength light: importance of both absolute and relative contents of melanopic component., Yuda E, Ogasawara H, Yoshida Y, Hayano J, Journal of physiological anthropology, 36, (1) , 01 31 , Refereed
  • Association between regional difference in heart rate variability and inter-prefecture ranking of healthy life expectancy: ALLSTAR big data project in Japan, Emi Yuda, Yuki Furukawa, Yutaka Yoshida, Junichiro Hayano, Lecture Notes of the Institute for Computer Sciences, Social-Informatics and Telecommunications Engineering, LNICST, 194 LNICST, 23 - 28, 01 01 , © ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering 2017. As a physiological big-data project named ALLSTAR, we have developed a 24-hr ambulatory electrocardiogram database of 81,615 males and 103,038 females (≥20 yr) from all over Japan. With this database, we examined if regional differences in heart rate (HR) and HR variability (HRV) are associated with the inter-prefecture rankings of healthy life expectancy (HALE) and of average life expectancy (ALE) in Japan. According to reports by the Japanese Ministry of Health, Labour and Welfare (2013), subjects in each sex were grouped into short, middle, and long HALE and ALE tertiles by their living prefectures. Standard deviation of 24-h normal-to-normal R-R intervals (SDNN) increased progressively with increasing HALE tertiles in both sexes (Ps < 0.001), while it showed no consistent associations with ALE. Conversely, HR decreased progressively with increasing ALE tertiles in females (P < 0.001), while it showed no consistent association with HALE. These suggest HRV may reflect a biological property relating to long HALE.
  • Multiscale properties of instantaneous parasympathetic activity in severe congestive heart failure: A survivor vs non-survivor study., Gaetano Valenza,Herwig Wendt,Ken Kiyono,Junichiro Hayano,Eiichi Watanabe,Yoshiharu Yamamoto,Patrice Abry,Riccardo Barbieri, 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Jeju Island, South Korea, July 11-15, 2017, 3761 - 3764, Refereed
  • Development of sleep-wake estimation algorithm using the wrist acceleration sensor., Yutaka Yoshida,Akira Kurata,Emi Yuda,Junichiro Hayano, IEEE 6th Global Conference on Consumer Electronics, GCCE 2017, Nagoya, Japan, October 24-27, 2017, 1 - 2, Refereed
  • Comparison of emotional impacts of interaction with remote controlled plush media and those with video call applications., Emi Yuda,Hiroki Ogasawara,Yutaka Yoshida,Junichiro Hayano, IEEE 6th Global Conference on Consumer Electronics, GCCE 2017, Nagoya, Japan, October 24-27, 2017, 1 - 3, Refereed
  • Life Style Modification by Peer Monitoring of Physical Activity., Emi Yuda,Akira Kurata,Yutaka Yoshida,Junichiro Hayano, Proceedings of the 14th EAI International Conference on Mobile and Ubiquitous Systems: Computing, Networking and Services, Melbourne, Australia, November 7-10, 2017., 520 - 522, Refereed
  • Fast algorithm of long-range cross-correlation analysis using Savitzky-Golay detrending filter and its application to biosignal analysis, 2017 INTERNATIONAL CONFERENCE ON NOISE AND FLUCTUATIONS (ICNF), Refereed
  • SLEEP STAGE CLASSIFICATION BY COMBINATION OF ACTIGRAPHIC AND HEART RATE SIGNALS, 2017 IEEE INTERNATIONAL CONFERENCE ON CONSUMER ELECTRONICS - TAIWAN (ICCE-TW), Refereed
  • Suppression of vagal cardiac modulation by blue light in healthy subjects., Yuda E, Ogasawara H, Yoshida Y, Hayano J, Journal of physiological anthropology, 35, (1) , 10 05 , Refereed
  • Circadian Contrasts in Heart Rate Variability Associated With Posttraumatic Stress Disorder Symptoms in a Young Adult Cohort., Rissling MB, Dennis PA, Watkins LL, Calhoun PS, Dennis MF, Beckham JC, Hayano J, Ulmer CS, Journal of traumatic stress, 29, (5) 415 - 421, 10 , Refereed
  • Blunted cyclic variation of heart rate predicts mortality risk in post-myocardial infarction, end-stage renal disease, and chronic heart failure patients., Hayano J, Yasuma F, Watanabe E, Carney RM, Stein PK, Blumenthal JA, Arsenos P, Gatzoulis KA, Takahashi H, Ishii H, Kiyono K, Yamamoto Y, Yoshida Y, Yuda E, Kodama I, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 19, (8) 1392 - 1400, 10 , Refereed
  • Exploring the relation between heart rate variability characteristics and sympathetic nervous system activity, Ken Kiyono, Junichiro Hayano, Yoshiharu Yamamoto, Anesthesia and Resuscitation, 52, 103 - 108, 09 01 , Heart rate variability (HRV) analysis has been widely used as a noninvasive assessment tool for autonomic nervous system function, and it has been shown that reduced and/or abnormal HRV is associated with an increased risk of mortality in cardiac patients. However, in the analysis of long-term HRV, it has become to be recognized that most HRV indices primarily reflect vagal function and that there is no established HRV-based index for evaluating sympathetic nervous system activity. This paper reviews the relation between conventional HRV indices and autonomic nervous system function. In addition, we introduce a non-Gaussianity index that have recently been proposed as a potential marker of sympathetic overactivity.
  • Examining the Crux of Autonomic Dysfunction in Posttraumatic Stress Disorder: Whether Chronic or Situational Distress Underlies Elevated Heart Rate and Attenuated Heart Rate Variability., Dennis PA, Dedert EA, Van Voorhees EE, Watkins LL, Hayano J, Calhoun PS, Sherwood A, Dennis MF, Beckham JC, Psychosomatic medicine, 78, (7) 805 - 809, 09 , Refereed
  • Long-range correlations in amplitude variability of HF and LF components of heart rate variability., Miki Y, Suzuki Y, Watanabe E, Hayano J, Yamamoto Y, Nomura T, Kiyono K, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2016, (EMBC) 6221 - 6221, 08 , Refereed
  • L/T-type calcium channel blocker reduces non-Gaussianity of heart rate variability in chronic kidney disease patients under preceding treatment with ARB., Fukuda M, Ogiyama Y, Sato R, Miura T, Fukuta H, Mizuno M, Kiyono K, Yamamoto Y, Hayano J, Ohte N, Journal of the renin-angiotensin-aldosterone system : JRAAS, 17, (2) , 04 , Refereed
  • Exploring the relationship between posttraumatic stress disorder symptoms and momentary heart rate variability., Green KT, Dennis PA, Neal LC, Hobkirk AL, Hicks TA, Watkins LL, Hayano J, Sherwood A, Calhoun PS, Beckham JC, Journal of psychosomatic research, 82, 31 - 34, 03 , Refereed
  • Autonomic nervous responses in colorectal polypectomy: Randomized controlled trial comparing air and carbon dioxide insufflation., Murakami K, Kataoka H, Hayano J, Fukuta H, Mori Y, Nishiwaki H, Mizoshita T, Tanaka M, Okamoto Y, Shimura T, Hirata Y, Mizushima T, Ebi M, Joh T, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 28, (2) 203 - 209, 03 , Refereed
  • Beat-to-beat T-wave amplitude variability in the risk stratification of right ventricular outflow tract-premature ventricular complex patients., Ichikawa T, Sobue Y, Kasai A, Kiyono K, Hayano J, Yamamoto M, Okuda K, Watanabe E, Ozaki Y, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 18, (1) 138 - 145, 01 01 , Refereed
  • Physical and Psychophysiological Impacts of GPS Labor Management in Nursing Home Workers., Emi Yuda,Yutaka Yoshida,Kazuo Mizuno,Harushi Urushihara,Junichiro Hayano, Proceedings of the 13th International Conference on Mobile and Ubiquitous Systems: Computing, Networking and Services, MobiQuitous 2016, Hiroshima, Japan, November 28 - December 1, 2016, Refereed
  • Longer lying position causes lower LF/HF of heart rate variability during ambulatory monitoring., Yutaka Yoshida,Yuki Furukawa,Hiroki Ogasawara,Emi Yuda,Junichiro Hayano, IEEE 5th Global Conference on Consumer Electronics, GCCE 2016, Kyoto, Japan, October 11-14, 2016, 1 - 2, Refereed
  • Multiscale Entropy of the Heart Rate Variability for the Prediction of an Ischemic Stroke in Patients with Permanent Atrial Fibrillation., Watanabe E, Kiyono K, Hayano J, Yamamoto Y, Inamasu J, Yamamoto M, Ichikawa T, Sobue Y, Harada M, Ozaki Y, PloS one, 10, (9) , 09 01 , Refereed
  • Relaxation enhances respiratory sinus arrhythmia, a cardiorespiratory resting function, Masahito Sakakibara, Masahito Sakakibara, Junichiro Hayano, Junichiro Hayano, Heart Rate Variability (HRV): Prognostic Significance, Risk Factors and Clinical Applications, 149 - 163, 01 01 , © 2015 by Nova Science Publishers, Inc. All rights reserved. Reduced heart rate variability (HRV) is associated with physical and mental stresses. Several studies have shown that relaxation techniques enhance respiratory sinus arrhythmia (RSA), which can be measured quantitatively as a high-frequency component of HRV. Although RSA is mediated by the respiratory modulation of cardiac vagal outflow and its magnitude has been used as an index of cardiac vagal activity, RSA itself is thought to be an intrinsic cardiorespiratory resting function (Hayano & Yasuma, 2003). When the breathing rate reduced, the presence of RSA improves pulmonary gas exchange efficiency by matching alveolar ventilation and capillary perfusion throughout the respiration cycle. The activation of RSA in cooperation with tonic vagal heart rate control selectively suppresses unnecessary heart beats, and effectively saves cardiorespiratory energy expenditure at rest. RSA increases during sleep and it is also activated according to the level of cardiopulmonary functional reserve at rest. Thus, RSA functions as an endogenous marker, which reflects the cardiorespiratory resting function. Recent studies have demonstrated that real-world stress decreases the magnitude of high-frequency component of HRV during sleep, whereas relaxation training increases the high- frequency component during sleep, suggesting that relaxation training may improve the cardiorespiratory resting function. Also, a number of studies have demonstrated that HRV biofeedback, an intervention aimed at increasing HRV, has clinical utility in the treatment of a variety of physical and mental disorders that involve autonomic nervous system dysrégulation. Further study would be worthwhile to examine whether relaxation training in real-life situations might enhance the cardiorespiratory resting function through increasing HRV, and help ameliorate psychophysiologic symptoms in clinical population.
  • Psychosocial factors are preventive against coronary events in Japanese men with coronary artery disease: The Eastern Collaborative Group Study 7.7-year follow-up experience., Hori R, Hayano J, Kimura K, Shibata N, Kobayashi F, BioPsychoSocial medicine, 9, (1) , Refereed
  • Point-process high-resolution representations of heartbeat dynamics for multiscale analysis: A CHF survivor prediction study., Valenza G, Wendt H, Kiyono K, Hayano J, Watanabe E, Yamamoto Y, Abry P, Barbieri R, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2015-November, 1951 - 1954, Refereed
  • Nocturnal patterns of heart rate and the risk of mortality after acute myocardial infarction., Carney RM, Steinmeyer B, Freedland KE, Stein PK, Hayano J, Blumenthal JA, Jaffe AS, American heart journal, 168, (1) 117 - 125, 07 , Refereed
  • Multiscale wavelet p-leader based heart rate variability analysis for survival probability assessment in CHF patients., Wendt H, Kiyono K, Abry P, Hayano J, Watanabe E, Yamamoto Y, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2014, 2809 - 2812, Refereed
  • Heart rate variability biofeedback improves cardiorespiratory resting function during sleep., Sakakibara M, Hayano J, Oikawa LO, Katsamanis M, Lehrer P, Applied psychophysiology and biofeedback, 38, (4) 265 - 271, 12 , Refereed
  • Site-specific organ-selective effect of epifascial acupuncture on cardiac and gastric autonomic functions., Minagawa M, Kurono Y, Ishigami T, Yamada A, Kakamu T, Akai R, Hayano J, Autonomic neuroscience : basic & clinical, 179, (1-2) 151 - 154, 12 , Refereed
  • Analogy of entrainment (respiratory modulation) of heartbeats in cheyne-stokes respiration in heart failure and respiratory sinus arrhythmia: Its physiological significance, Fumihiko Yasuma, Tamotsu Tanahashi, Jun Ichiro Hayano, Yuuki Shimizu, Toyoaki Murohara, Respiration and Circulation, 61, 944 - 950, 10 01
  • Central sleep apnoea and inflammation are independently associated with arrhythmia in patients with heart failure., Sano K, Watanabe E, Hayano J, Mieno Y, Sobue Y, Yamamoto M, Ichikawa T, Sakakibara H, Imaizumi K, Ozaki Y, European journal of heart failure, 15, (9) 1003 - 1010, 09 , Refereed
  • Multi-scale heart rate dynamics detected by phase-rectified signal averaging predicts mortality after acute myocardial infarction., Kisohara M, Stein PK, Yoshida Y, Suzuki M, Iizuka N, Carney RM, Watkins LL, Freedland KE, Blumenthal JA, Hayano J, Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 15, (3) 437 - 443, 03 , Refereed
  • Accuracy of ECG-based screening for sleep-disordered breathing: a survey of all male workers in a transport company., Hayano J, Tsukahara T, Watanabe E, Sasaki F, Kawai K, Sakakibara H, Kodama I, Nomiyama T, Fujimoto K, Sleep & breathing = Schlaf & Atmung, 17, (1) 243 - 251, 03 , Refereed
  • Assessment of Sympathetic Over Activity by the Analysis of Nonlinear Heart Rate Dynamics, Hayano Junichiro, JOURNAL OF PHYSIOLOGICAL SCIENCES, 63, Refereed
  • Interactive associations of depression and sleep apnea with adverse clinical outcomes after acute myocardial infarction., Hayano J, Carney RM, Watanabe E, Kawai K, Kodama I, Stein PK, Watkins LL, Freedland KE, Blumenthal JA, Psychosomatic medicine, 74, (8) 832 - 839, 10 , Refereed
  • Nonlinear measures of heart rate variability and mortality risk in hemodialysis patients., Suzuki M, Hiroshi T, Aoyama T, Tanaka M, Ishii H, Kisohara M, Iizuka N, Murohara T, Hayano J, Clinical journal of the American Society of Nephrology : CJASN, 7, (9) 1454 - 1460, 09 , Refereed
  • Cardiac β-adrenergic receptor density and myocardial systolic function in the remote noninfarcted region after prior myocardial infarction with left ventricular remodelling., Ohte N, Narita H, Iida A, Fukuta H, Iizuka N, Hayano J, Kuge Y, Tamaki N, Kimura G, European journal of nuclear medicine and molecular imaging, 39, (8) 1246 - 1253, 08 , Refereed
  • Effect of obstructive sleep apnea on response to cognitive behavior therapy for depression after an acute myocardial infarction., Freedland KE, Carney RM, Hayano J, Steinmeyer BC, Reese RL, Roest AM, Journal of psychosomatic research, 72, (4) 276 - 281, 04 , Refereed
  • LONG-TIME-SCALE HEART RATE DYNAMICS DETECTED BY PHASE-RECTIFIED SIGNAL AVERAGING PREDICTS MORTALITY AFTER ACUTE MYOCARDIAL INFARCTION, Kisohara Masaya, Suzuki Mari, Iizuka Narushi, Carney Robert, Stein Phyllis, Watkins Lana L., Freedland Kenneth, Blumenthal James, Hayano Junichiro, JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 59, (13) , 03 27 , Refereed
  • Autonomic antagonism underlies heart rate complexity, Zbigniew R. Struzik, Ken Kiyono, Junihiro Hayano, Shin Kwak, Yoshiharu Yamamoto, Acta Physica Polonica B, Proceedings Supplement, 5, 181 - 190, 03 26 , We investigate multiscale properties of intermittency of heart rate variability (HRV) through non-Gaussianity and through two-point one-scale magnitude correlations in HRV of patients with congestive heart failure (CHF) - both survivors (CHF-SV) and non-survivors (CHF-NS) - and of patients with primary autonomic failure (PAF). We confirm the sympathetic origin of the non-Gaussianity index elucidating its random character. We further confirm intermittency of the high frequency, fine scale firing of the parasympathetic nervous system branch, responsible for the multifractal complexity. We obtain further confirmation of the antagonistic function of the autonomic regulation of HRV, this time in terms of intermittency - heteroscedastic clustering of variance. In this context, we identify autonomic antagonism as the source of the mid to low frequency, intermediate scale intermittency observed at higher levels in CHF patients with elevated sympathetic activation and suppressed in the PAF patients - the case of neurogenic SNS dysfunction.
  • Non-gaussianity of low frequency heart rate variability and sympathetic activation: lack of increases in multiple system atrophy and Parkinson disease., Kiyono K, Hayano J, Kwak S, Watanabe E, Yamamoto Y, Frontiers in physiology, 3 FEB, Refereed
  • Allostasis: A New Paradigm for Detecting Ultra-Early Signs of Cardiovascular Diseases, Junichiro Hayano, Transactions of Japanese Society for Medical and Biological Engineering, 49, 372 - 374, 12 14
  • HRV Biofeedback Improves Cardiorespiratory Resting Function During Sleep, Sakakibara Masahito, Hayano Junichiro, Oikawa Leo, Katsamanis Maria, Lehrer Paul, APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK, 36, (3) , 09 , Refereed
  • Acupuncture to Danzhong but not to Zhongting increases the cardiac vagal component of heart rate variability., Kurono Y, Minagawa M, Ishigami T, Yamada A, Kakamu T, Hayano J, Autonomic neuroscience : basic & clinical, 161, (1-2) 116 - 120, 04 26 , Refereed
  • Screening for obstructive sleep apnea by cyclic variation of heart rate., Hayano J, Watanabe E, Saito Y, Sasaki F, Fujimoto K, Nomiyama T, Kawai K, Kodama I, Sakakibara H, Circulation. Arrhythmia and electrophysiology, 4, (1) 64 - 72, 02 , Refereed
  • Sleep Apnea and Cardiac Arrhythmias, Junichiro Hayano, journal of arrhythmia, 27, 01 01 , Obstructive sleep apnea (OSA) is common among cardiac patients and associated with serious cardiovascular complications, including cardiac arrhythmias and sudden cardiac death. OSA is characterized by repeated obstruction of the upper airway, resulting in intermittent oxygen desaturation during sleep and transient repetitive arousal from sleep. Inspiratory effort against the airway obstruction causes an increase in left ventricular wall stress. Frequent episodes of hypoxemia have been associated with increased sympathetic activity, endothelial dysfunction and systemic inflammation. Epidemiologic observations indicted that OSA is associated with atrial fibrillation (AF) and is an increased risk for development of AF in individuals <65 years of age. Patients with OSA have a peak in sudden cardiac death during sleeping hours, when peoples without OSA show a nadir. Majority of cardiac patients with moderate-to-severe OSA, however, remain undiagnosed. This is due mainly to cost and inconvenience of the standard diagnosis of sleep apnea by polysomnographic examination. Each episode of sleep apnea is accompanied by bradycardia followed by abrupt tachycardia upon its cessation, resulting in a characteristic heart rate pattern, called cyclic variation of heart rate (CVHR). Recently, we developed an algorithm, named autocorrelated wave detection with adaptive threshold (ACAT) for detecting CVHR from Holter ECG recording during sleep. ACAT may provide a powerful screening tool for sleep apnea among cardiac patients and CVHR may be a new index in routine Holter ECG examinations for cardiac arrhythmias. © 2011, Japanese Heart Rhythm Society. All rights reserved.
  • Cardiovascular tolerance and autonomic nervous responses in unsedated upper gastrointestinal small-caliber endoscopy: a comparison between transnasal and peroral procedures with newly developed mouthpiece., Kataoka H, Hayano J, Mizushima T, Tanaka M, Kubota E, Shimura T, Mizoshita T, Tanida S, Kamiya T, Nojiri S, Mukai S, Mizuno K, Joh T, Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society, 23, (1) 78 - 85, 01 , Refereed
  • Increased non-gaussianity of heart rate variability predicts cardiac mortality after an acute myocardial infarction., Hayano J, Kiyono K, Struzik ZR, Yamamoto Y, Watanabe E, Stein PK, Watkins LL, Blumenthal JA, Carney RM, Frontiers in physiology, 2 SEP, Refereed
  • Asymmetric intermittency observed in human heart rate dynamics., Kiyono K, Struzik ZR, Hayano J, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2011, 7743 - 7746, Refereed
  • Diagnosis of sleep apnea by the analysis of heart rate variation: a mini review., Hayano J, Watanabe E, Saito Y, Sasaki F, Kawai K, Kodama I, Sakakibara H, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference, 2011, 7731 - 7734, Refereed
  • Effect of HRV Biofeedback on Cardiorespiratory Resting Function During Sleep, Sakakibara Masahito, Hayano Junichiro, Oikawa Leo, Karavidas Maria, Lehrer Paul, APPLIED PSYCHOPHYSIOLOGY AND BIOFEEDBACK, 35, (4) , 12 , Refereed
  • Cost-Effective Screening for Obstructive Sleep Apnea by Automated ECG Detection of Cyclic Variation of Heart Rate, Hayano Junichiro, Watanabe Eiichi, Saito Yuji, Sasaki Fumihiko, Fujimoto Keisaku, Nomiyama Tetsuo, Kawai Kiyohiro, Kodama Itsuo, Sakakibara Hiroki, CIRCULATION, 122, (21) , 11 23 , Refereed
  • Depression, alexithymia and long-term mortality in chronic hemodialysis patients., Kojima M, Hayano J, Suzuki S, Seno H, Kasuga H, Takahashi H, Toriyama T, Kawahara H, Furukawa TA, Psychotherapy and psychosomatics, 79, (5) 303 - 311, Refereed
  • Nighttime heart rate and survival in depressed patients post acute myocardial infarction., Carney RM, Steinmeyer B, Freedland KE, Blumenthal JA, Stein PK, Steinhoff WA, Howells WB, Berkman LF, Watkins LL, Czajkowski SM, Domitrovich PP, Burg MM, Hayano J, Jaffe AS, Psychosomatic medicine, 70, (7) 757 - 763, 09 , Refereed
  • Impact of real-world stress on cardiorespiratory resting function during sleep in daily life., Sakakibara M, Kanematsu T, Yasuma F, Hayano J, Psychophysiology, 45, (4) 667 - 670, 07 , Refereed
  • Increased heteroscedasticity of heart rate in fatal heart failure, Z. R. Struzik, K. Kiyono, J. Hayano, E. Watanabe, Y. Yamamoto, EPL, 82, 04 01 , Healthy human heart rate is known to fluctuate in a highly complex manner, displaying complexity characteristics such as those shared by physical systems at a critical state. It is, however, widely believed that chronic heart failure reduces this complexity and that heart rate data from chronic-heart-failure patients can be used for the validation of complexity measures and paradigms applicable both to heart rate and more generally to assess any system's complexity. Here, we counter the above belief, showing an increase in fluctuations and in complexity of heart rate in chronic-heart-failure patients, in particular those at risk of death. This is supported by evidence of increased non-Gaussianity and heteroscedasticity resulting from the emergence of a characteristic correlation scale in the magnitude correlation landscape. © Europhysics Letters Association.
  • Loss of fractal heart rate dynamics in depressive hemodialysis patients., Kojima M, Hayano J, Fukuta H, Sakata S, Mukai S, Ohte N, Seno H, Toriyama T, Kawahara H, Furukawa TA, Tokudome S, Psychosomatic medicine, 70, (2) 177 - 185, 02 , Refereed
  • Non-Gaussian heart rate as an independent predictor of mortality in patients with chronic heart failure., Kiyono K, Hayano J, Watanabe E, Struzik ZR, Yamamoto Y, Heart rhythm, 5, (2) 261 - 268, 02 , Refereed
  • Relationship between blood pressure obtained from the upper arm with a cuff-type sphygmomanometer and central blood pressure measured with a catheter-tipped micromanometer., Ohte N, Saeki T, Miyabe H, Sakata S, Mukai S, Hayano J, Niki K, Sugawara M, Kimura G, Heart and vessels, 22, (6) 410 - 415, 11 , Refereed
  • Independent associations of alexithymia and social support with depression in hemodialysis patients., Kojima M, Hayano J, Tokudome S, Suzuki S, Ibuki K, Tomizawa H, Nakata A, Seno H, Toriyama T, Kawahara H, Furukawa TA, Journal of psychosomatic research, 63, (4) 349 - 356, 10 , Refereed
  • Cardiac vagal activation by adrenocorticotropic hormone treatment in infants with West syndrome., Hattori A, Hayano J, Fujimoto S, Ando N, Mizuno K, Kamei M, Kobayashi S, Ishikawa T, Togari H, The Tohoku journal of experimental medicine, 211, (2) 133 - 139, 02 , Refereed
  • Heart rate turbulence, depression, and survival after acute myocardial infarction., Carney RM, Howells WB, Blumenthal JA, Freedland KE, Stein PK, Berkman LF, Watkins LL, Czajkowski SM, Steinmeyer B, Hayano J, Domitrovich PP, Burg MM, Jaffe AS, Psychosomatic medicine, 69, (1) 4 - 9, 01 , Refereed
  • Changes in chemosensitivity with continuous positive airway pressure of 5 cm H2O for cheyne-stokes respiration in congestive heart failure., Yasuma F, Mori T, Noguchi M, Kuru S, Konagaya M, Hayano J, Respiration; international review of thoracic diseases, 74, (4) 475 - 477, Refereed
  • Exponential distribution of long heart beat intervals during atrial fibrillation and their relevance for white noise behaviour in power spectrum., Hennig T, Maass P, Hayano J, Heinrichs S, Journal of biological physics, 32, (5) 383 - 392, 11 , Refereed
  • Vagal nerve activity contributes to improve the efficiency of pulmonary gas exchange in hypoxic humans., Ito S, Sasano H, Sasano N, Hayano J, Fisher JA, Katsuya H, Experimental physiology, 91, (5) 935 - 941, 09 01 , Refereed
  • Long-term efficacy of acetazolamide on Cheyne-Stokes respiration in congestive heart failure [1], Fumihiko Yasuma, Toyoaki Murohara, Junichiro Hayano, American Journal of Respiratory and Critical Care Medicine, 174, 08 15
  • Long-term efficacy of acetazolamide on Cheyne-Stokes respiration in congestive heart failure., Yasuma F, Murohara T, Hayano J, American journal of respiratory and critical care medicine, 174, (4) 479; author reply 479 - 80, 08 , Refereed
  • Quality of care associated with number of cases seen and self-reports of clinical competence for Japanese physicians-in-training in internal medicine., Hayashino Y, Fukuhara S, Matsui K, Noguchi Y, Minami T, Bertenthal D, Peabody JW, Mutoh Y, Hirao Y, Kikawa K, Fukumoto Y, Hayano J, Ino T, Sawada U, Seino J, Higuma N, Ishimaru H, BMC medical education, 6, 06 , Refereed
  • Aging of complex heart rate dynamics., Struzik ZR, Hayano J, Soma R, Kwak S, Yamamoto Y, IEEE transactions on bio-medical engineering, 53, (1) 89 - 94, 01 , Refereed
  • Aging of complex heart rate dynamics., Array,Junichiro Hayano,R. Soma,Shin Kwak,Yoshiharu Yamamoto, IEEE Trans. Biomed. Engineering, 53, (1) 89 - 94, Refereed
  • Assessment of pulse rate variability by the method of pulse frequency demodulation., Hayano J, Barros AK, Kamiya A, Ohte N, Yasuma F, Biomedical engineering online, 4, 11 , Refereed
  • Acute effects of cigarette smoking on the heart rate variability of taxi drivers during work., Kobayashi F, Watanabe T, Akamatsu Y, Furui H, Tomita T, Ohashi R, Hayano J, Scandinavian journal of work, environment & health, 31, (5) 360 - 366, 10 , Refereed
  • Low-frequency oscillation of sympathetic nerve activity decreases during development of tilt-induced syncope preceding sympathetic withdrawal and bradycardia., Kamiya A, Hayano J, Kawada T, Michikami D, Yamamoto K, Ariumi H, Shimizu S, Uemura K, Miyamoto T, Aiba T, Sunagawa K, Sugimachi M, American journal of physiology. Heart and circulatory physiology, 289, (4) H1758 - 69, 10 , Refereed
  • Effects of the muscle pump and body posture on cardiovascular responses during recovery from cycle exercise., Takahashi T, Hayano J, Okada A, Saitoh T, Kamiya A, European journal of applied physiology, 94, (5-6) 576 - 583, 08 , Refereed
  • Low heart rate variability and the effect of depression on post-myocardial infarction mortality., Carney RM, Blumenthal JA, Freedland KE, Stein PK, Howells WB, Berkman LF, Watkins LL, Czajkowski SM, Hayano J, Domitrovich PP, Jaffe AS, Archives of internal medicine, 165, (13) 1486 - 1491, 07 , Refereed
  • Usefulness of plasma brain-type natriuretic peptide level to differentiate left ventricular diastolic dysfunction from preserved diastolic function in patients with systolic dysfunction., Goto T, Ohte N, Miyabe H, Sakata S, Asada K, Mukai S, Hayano J, Kimura G, The American journal of cardiology, 95, (11) 1383 - 1385, 06 , Refereed
  • Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial., Blumenthal JA, Sherwood A, Babyak MA, Watkins LL, Waugh R, Georgiades A, Bacon SL, Hayano J, Coleman RE, Hinderliter A, JAMA, 293, (13) 1626 - 1634, 04 , Refereed
  • Tl-201 washout rate in remote normal regions in patients with prior myocardial infarction and left ventricular remodeling., Goto T, Ohte N, Miyabe H, Mukai S, Sakata S, Hayano J, Kimura G, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 12, (2) 179 - 185, 03 , Refereed
  • 1/f scaling in heart rate requires antagonistic autonomic control., Struzik ZR, Hayano J, Sakata S, Kwak S, Yamamoto Y, Physical review. E, Statistical, nonlinear, and soft matter physics, 70, (5 Pt 1) , 11 , Refereed
  • Heartbeat synchronizes with respiratory rhythm only under specific circumstances [6] (multiple letters), Evgeny Vaschillo, Bronya Vaschillo, Paul Lehrer, Paul Lehrer, Fumihiko Yasuma, Fumihiko Yasuma, Jun Ichiro Hayano, Chest, 126, 1385 - 1387, 10 01
  • Critical scale invariance in a healthy human heart rate., Kiyono K, Struzik ZR, Aoyagi N, Sakata S, Hayano J, Yamamoto Y, Physical review letters, 93, (17) , 10 , Refereed
  • Evaluation of whole left ventricular systolic performance and local myocardial systolic function in patients with prior myocardial infarction using global long-axis myocardial strain., Ohte N, Narita H, Miyabe H, Takada N, Goto T, Mizuno H, Asada K, Hayano J, Kimura G, The American journal of cardiology, 94, (7) 929 - 932, 10 , Refereed
  • Effects of daily stress on autonomic cardiac control in patients with coronary artery disease., Bacon SL, Watkins LL, Babyak M, Sherwood A, Hayano J, Hinderliter AL, Waugh R, Blumenthal JA, The American journal of cardiology, 93, (10) 1292 - 1294, 05 , Refereed
  • Bed rest attenuates sympathetic and pressor responses to isometric exercise in antigravity leg muscles in humans., Kamiya A, Michikami D, Shiozawa T, Iwase S, Hayano J, Kawada T, Sunagawa K, Mano T, American journal of physiology. Regulatory, integrative and comparative physiology, 286, (5) R844 - 50, 05 , Refereed
  • Respiratory sinus arrhythmia: why does the heartbeat synchronize with respiratory rhythm?, Yasuma F, Hayano J, Chest, 125, (2) 683 - 690, 02 , Refereed
  • Alpha-adrenergic vascular responsiveness to sympathetic nerve activity is intact after head-down bed rest in humans., Kamiya A, Michikami D, Iwase S, Hayano J, Kawada T, Sugimachi M, Sunagawa K, American journal of physiology. Regulatory, integrative and comparative physiology, 286, (1) R151 - 7, 01 , Refereed
  • Rhythm-independent feature of heart rate dynamics common to atrial fibrillation and sinus rhythm in patients with paroxysmal atrial fibrillation., Sato K, Yamasaki F, Furuno T, Hamada T, Mukai S, Hayano J, Sugiura T, Doi Y, Journal of cardiology, 42, (6) 269 - 276, 12 , Refereed
  • The role of apically directed intraventricular isovolumic relaxation flow in speeding early diastolic left ventricular filling., Yanada A, Ohte N, Narita H, Akita S, Miyabe H, Takada N, Goto T, Mukai S, Hayano J, Kimura G, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 16, (12) 1226 - 1230, 12 , Refereed
  • Depression as a risk factor for mortality after acute myocardial infarction., Carney RM, Blumenthal JA, Catellier D, Freedland KE, Berkman LF, Watkins LL, Czajkowski SM, Hayano J, Jaffe AS, The American journal of cardiology, 92, (11) 1277 - 1281, 12 , Refereed
  • Reverse redistribution phenomenon on rest (99m)Tc-tetrofosmin myocardial single photon emission computed tomography involves impaired left ventricular contraction in patients with acute myocardial infarction., Kurokawa K, Ohte N, Miyabe H, Akita S, Yajima K, Hayano J, Kimura G, Circulation journal : official journal of the Japanese Circulation Society, 67, (10) 830 - 834, 10 , Refereed
  • Pathophysiology of orthostatic hypotension after bed rest: paradoxical sympathetic withdrawal., Kamiya A, Michikami D, Fu Q, Iwase S, Hayano J, Kawada T, Mano T, Sunagawa K, American journal of physiology. Heart and circulatory physiology, 285, (3) H1158 - 67, 09 , Refereed
  • Prognostic value of nonlinear heart rate dynamics in hemodialysis patients with coronary artery disease., Fukuta H, Hayano J, Ishihara S, Sakata S, Ohte N, Takahashi H, Yokoya M, Toriyama T, Kawahara H, Yajima K, Kobayashi K, Kimura G, Kidney international, 64, (2) 641 - 648, 08 , Refereed
  • Clinical usefulness of carotid arterial wave intensity in assessing left ventricular systolic and early diastolic performance., Ohte N, Narita H, Sugawara M, Niki K, Okada T, Harada A, Hayano J, Kimura G, Heart and vessels, 18, (3) 107 - 111, 07 , Refereed
  • Heat stress modifies human baroreflex function independently of heat-induced hypovolemia., Kamiya A, Michikami D, Hayano J, Sunagawa K, The Japanese journal of physiology, 53, (3) 215 - 222, 06 , Refereed
  • Hypothesis: respiratory sinus arrhythmia is an intrinsic resting function of cardiopulmonary system., Hayano J, Yasuma F, Cardiovascular research, 58, (1) 1 - 9, 04 , Refereed
  • Coronary-prone behavior among Japanese men., Hori R, Hayano J, Monou H, Kimura K, Tsuboi H, Kamiya T, Kobayashi F, Type A Behavior Pattern Conference., Circulation journal : official journal of the Japanese Circulation Society, 67, (2) 129 - 132, 02 , Refereed
  • Prognostic value of heart rate variability in patients with end-stage renal disease on chronic haemodialysis., Fukuta H, Hayano J, Ishihara S, Sakata S, Mukai S, Ohte N, Ojika K, Yagi K, Matsumoto H, Sohmiya S, Kimura G, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 18, (2) 318 - 325, 02 , Refereed
  • Responses of heart rate and vagus tone to treadmill walking on land and in water in healthy older adults, Tatsuhisa Takahashi, Akiyoshi Okada, Jun ichiro Hayano, Nobuo Takeshima, Journal of Aging and Physical Activity, 11, 18 - 26, 01 01 , To determine water immersion's effect on heart rate (HR) and vagal tone, the authors examined HR and high-frequency R-R-interval variability in 7 healthy older adults at rest and during treadmill walking, starting at 3.0 km/hr and increasing 0.5 km/hr every 3 min at a 5% grade to exhaustion. Participants performed the test on land and then immersed in water to the xiphoid. HR at rest did not differ between water and land. During walking at 3.0 km/min, HR was significantly lower in water than on land, whereas at 4.5 and 5.0 km/min it was significantly higher (each p <.05). Peak HR at exhaustion was not significantly different between water and land. High-frequency amplitudes at rest and during exercise in water were not significantly different from those on land. The results suggest that resting vagus tone and vagal changes in response to walking exercise in elderly adults are not greatly affected by water immersion.
  • Blood pressure and heart rate variability in taxi drivers on long duty schedules, Fumio Kobayashi, Fumio Kobayashi, Takemasa Watanabe, Misuzu Watanabe, Yasuhiro Akamatsu, Teruyuki Tomita, Taisuke Nakane, Hikari Furui, Kiyomi Takeuchi, Akiyoshi Okada, Rumi Ohashi, Junichiro Hayano, Journal of Occupational Health, 44, 214 - 220, 07 01 , Objective - To clarify the mechanisms of excessive risk of cardiovascular disease among taxi drivers, the effects of taxi driving with long work hours on taxi drivers' blood pressure and heart rate variability were examined. Methods - We measured the physical activity level, ambulatory blood pressure, and Holter ECG in 34 healthy middle-aged male taxi drivers over one work day and the two following non-work days. The subjects worked for a 24-h period starting at 07:00, then rested from work for 48 h. Ambulatory blood pressure was recorded automatically at 30-min intervals over the 72-h period. Holter ECG records were also kept for the 72 h, and temporal changes in the R-R interval were analyzed by the complex demodulation method (CDM). The amplitude of the high frequency (HF) components (central frequency 0.30 Hz), and the ratio of low-frequency components (central frequency 0.09 Hz) to high-frequency components (L/H) was calculated. Results - Blood pressure during the work day was significantly higher than that during the non-work days, with a stronger effect in the hypertensive subjects. There were no significant overall differences in heart rate variability between the work day and the non-work days, but the temporal patterns of HF and L/H on the work day revealed a potent effect of reversed-phased circadian rhythm for work at night. Conclusions - Long duty taxi driving raises blood pressure and may increase cardiovascular risk as a result. The conflict between the circadian rhythms of autonomic nervous activity and work activity at night may also result in increased risk.
  • The mechanism of emergence and clinical significance of apically directed intraventricular flow during isovolumic relaxation., Ohte N, Narita H, Akita S, Kurokawa K, Hayano J, Sugawara M, Kimura G, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 15, (7) 715 - 722, 07 , Refereed
  • Myocardial oxidative metabolism in remote normal regions in the left ventricles with remodeling after myocardial infarction: effect of beta-adrenoceptor blockers., Ohte N, Kurokawa K, Iida A, Narita H, Akita S, Yajima K, Miyabe H, Hayano J, Kimura G, Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 43, (6) 780 - 785, 06 , Refereed
  • Circadian rhythm of atrioventricular conduction predicts long-term survival in patients with chronic atrial fibrillation., Hayano J, Ishihara S, Fukuta H, Sakata S, Mukai S, Ohte N, Kimura G, Chronobiology international, 19, (3) 633 - 648, 05 , Refereed
  • Respiratory sinus arrhythmia : Mechanisms and implications, Fumihiko Yasuma, Jun Ichiro Hayano, Respiration and Circulation, 50, 283 - 289, 03 01
  • Striking effect of left ventricular high filling pressure with mitral regurgitation on mitral annular velocity during early diastole. A study using colour M-mode tissue Doppler imaging., Ohte N, Narita H, Akita S, Kurokawa K, Hayano J, Kimura G, European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology, 3, (1) 52 - 58, 03 , Refereed
  • Water-based exercise improves health-related aspects of fitness in older women., Takeshima N, Rogers ME, Watanabe E, Brechue WF, Okada A, Yamada T, Islam MM, Hayano J, Medicine and science in sports and exercise, 34, (3) 544 - 551, 03 , Refereed
  • Direct effect of Pa(CO2) on respiratory sinus arrhythmia in conscious humans., Sasano N, Vesely AE, Hayano J, Sasano H, Somogyi R, Preiss D, Miyasaka K, Katsuya H, Iscoe S, Fisher JA, American journal of physiology. Heart and circulatory physiology, 282, (3) H973 - 6, 03 , Refereed
  • Influence of cool-down exercise on autonomic control of heart rate during recovery from dynamic exercise., Takahashi T, Okada A, Hayano J, Tamura T, Frontiers of medical and biological engineering : the international journal of the Japan Society of Medical Electronics and Biological Engineering, 11, (4) 249 - 259, Refereed
  • Postural response of low-frequency component of heart rate variability is an increased risk for mortality in patients with coronary artery disease., Hayano J, Mukai S, Fukuta H, Sakata S, Ohte N, Kimura G, Chest, 120, (6) 1942 - 1952, 12 , Refereed
  • Striking effect of left ventricular systolic performance on propagation velocity of left ventricular early diastolic filling flow., Ohte N, Narita H, Akita S, Kurokawa K, Hayano J, Kimura G, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 14, (11) 1070 - 1074, 11 , Refereed
  • Differential effects of hypoxia and hypercapnia on respiratory sinus arrhythmia in conscious dogs., Yasuma F, Hirai M, Hayano JI, Japanese circulation journal, 65, (8) 738 - 742, 08 , Refereed
  • Augmentation of respiratory sinus arrhythmia in response to progressive hypercapnia in conscious dogs., Yasuma F, Hayano J, American journal of physiology. Heart and circulatory physiology, 280, (5) H2336 - 41, 05 , Refereed
  • Impact of acute hypoxia on heart rate and blood pressure variability in conscious dogs., Yasuma F, Hayano JI, American journal of physiology. Heart and circulatory physiology, 279, (5) H2344 - 9, 11 , Refereed
  • Effects of shift work on 24-hour ambulatory blood pressure and its variability among Japanese workers., Ohira T, Tanigawa T, Iso H, Odagiri Y, Takamiya T, Shimomitsu T, Hayano J, Shimamoto T, Scandinavian journal of work, environment & health, 26, (5) 421 - 426, 10 , Refereed
  • Reduced ventricular response irregularity is associated with increased mortality in patients with chronic atrial fibrillation., Yamada A, Hayano J, Sakata S, Okada A, Mukai S, Ohte N, Kimura G, Circulation, 102, (3) 300 - 306, 07 , Refereed
  • Exercise and weight loss reduce blood pressure in men and women with mild hypertension: effects on cardiovascular, metabolic, and hemodynamic functioning., Blumenthal JA, Sherwood A, Gullette EC, Babyak M, Waugh R, Georgiades A, Craighead LW, Tweedy D, Feinglos M, Appelbaum M, Hayano J, Hinderliter A, Archives of internal medicine, 160, (13) 1947 - 1958, 07 , Refereed
  • Difference in human cardiovascular response between upright and supine recovery from upright cycle exercise., Takahashi T, Okada A, Saitoh T, Hayano J, Miyamoto Y, European journal of applied physiology, 81, (3) 233 - 239, 02 , Refereed
  • A case of anorexia nervosa with hyperinsulinemia and severe hypoglycemia induced by elemental diet (Elental®), M. Okada, Y. Kamiya, Y. Kanno, J. Hayano, S. Ishihara, A. Okada, S. Takeuchi, M. Kawaguchi, Journal of the Japan Diabetes Society, 43, 373 - 377, 01 01
  • [Sodium sensitivity in essential hypertension]., Hayano J, Kimura G, Nihon rinsho. Japanese journal of clinical medicine, 58 Suppl 1, 388 - 391, 01 , Refereed
  • Differentiation of abnormal relaxation pattern with aging from abnormal relaxation pattern with coronary artery disease in transmitral flow with the use of tissue Doppler imaging of the mitral annulus., Ohte N, Narita H, Hashimoto T, Hayano J, Akita S, Kurokawa K, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 12, (8) 629 - 635, 08 , Refereed
  • Effects of sympathetic nerve blockades on low-frequency oscillations of human earlobe skin blood flow., Sasano H, Hayano J, Tsuda T, Katsuya H, Journal of the autonomic nervous system, 77, (1) 60 - 67, 07 , Refereed
  • Prognostic value of heart rate variability during long-term follow-up in chronic haemodialysis patients with end-stage renal disease., Hayano J, Takahashi H, Toriyama T, Mukai S, Okada A, Sakata S, Yamada A, Ohte N, Kawahara H, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 14, (6) 1480 - 1488, 06 , Refereed
  • Aging and spectral characteristics of the nonharmonic component of 24-h heart rate variability., Sakata S, Hayano J, Mukai S, Okada A, Fujinami T, The American journal of physiology, 276, (6 Pt 2) R1724 - 31, 06 , Refereed
  • The current situation of psychosomatic medicine in the United States of America, J. I. Hayano, Japanese Journal of Psychosomatic Medicine, 39, 29 - 34, 01 01 , To depict the current trends of the psychosomatic medicine in the USA, the changes during the past decade in the membership of the American Psychosomatic Society (APS) and in the major topics of the papers published in the journal, Psychosomatic Medicine, were investigated. The majority of the APS members hold a degree of MD, about half are psychiatrists, but the society is changing with an increased frequency of new PhD psychologists. Major areas of interest include behavioral medicine, consultation-liaison, cardiovascular diseases and psychotherapy. Top 3 topics in the papers published in Psychosomatic Medicine during the past decade have been coronary artery diseases, depression and hypertension. Recently, however, panic disorder is gathering increasing attentions. The APS keeps its uniqueness by maintaining the broad membership spectrum and by staying responsive to the varied interests of the members. Psychosomatic medicine in the USA has been challenging the most important medical and social problems in each era with using the most modern techniques of researches, such as megatrials and evidence-based medicine, through which it has been gaining a high reputation from both medical and general societies.
  • Is the blood flow in the left ventricle during the isovolumic relaxation period a useful parameter of left ventricular systolic and early diastolic performance?, Ohte N, Narita H, Hashimoto T, Hayano J, Akita S, Kurokawa K, Cardiology, 91, (3) 184 - 188, Refereed
  • Influence of body composition on electrocardiographic identification of left ventricular hypertrophy in adolescents., Sugita S, Takada K, Hayano J, Cardiology, 91, (2) 127 - 133, Refereed
  • The relationship between R amplitude in lead V5 (RV5) and left ventricular mass in the groups of adolescent subjects classified by body composition., Sugita S, Takada K, Takada H, Nagashima M, Hayano J, Japanese circulation journal, 62, (12) 893 - 899, 12 , Refereed
  • Complex demodulation of cardiorespiratory dynamics preceding vasovagal syncope., Lipsitz LA, Hayano J, Sakata S, Okada A, Morin RJ, Circulation, 98, (10) 977 - 983, 09 , Refereed
  • Estimation of subjective workload during motorcycle riding by logistic regression model with indices of heart rate variability, Yasufumi Mizuno, Kiyoko Yokoyama, Seiji Mukai, Junichiro Hayano, Kazuyuki Takata, Japanese Journal of Medical Electronics and Biological Engineering, 36, 1 - 6, 03 01 , To examine if the workload during motorcycle riding is estimated by heart rate variability, we analyzed the multivariate relationships between subjective feeling and indices of R-R interval variability in 14 healthy men during 400-km highway motorcycle driving. Logistic regression analysis revealed that the subjective fatigue assessed by questionnaire was estimated by a two-variate model including mean R-R interval (RRM) and the power of high-frequency component (HFP). By analyzed the pattern of the change in RRM and HFP, the fatigue occurred in the following three conditions: 1) increases in both RRM and HFP, 2) decreased RRM with increased HFP, and 3) decreases in both RRM and HFP, which seemed to correspond to the situations of 1) decreased arousal level, 2) difficulty in the concentration to drive despite high arousal level, and 3) maintaining concentration ability under distress, respectively. These results indicate that the subjective workload during motorcycle riding is estimated from autonomic indices of heart rate variability. The regression model obtained in this study seems useful for the quantitative assessment of the effects of difference in machine and in driving condition on the workload during motorcycle riding.
  • Circadian rhythms of atrioventricular conduction properties in chronic atrial fibrillation with and without heart failure., Hayano J, Sakata S, Okada A, Mukai S, Fujinami T, Journal of the American College of Cardiology, 31, (1) 158 - 166, 01 , Refereed
  • Fractional removal rate of fat emulsion (K2) remains to be low in APOE3/3 phenotype subjects with serum triglyceride level above 180mg/dl., Ikeuchi R, Sakuma N, Hayano J, Fujinami T, Life sciences, 62, (7) 665 - 671, Refereed
  • Respiratory sinus arrhythmia. A phenomenon improving pulmonary gas exchange and circulatory efficiency, J. Hayano, F. Yasuma, A. Okada, S. Mukai, T. Fujinami, Pneumologie, 51, 12 01
  • Spectral characteristics of ventricular response to atrial fibrillation., Hayano J, Yamasaki F, Sakata S, Okada A, Mukai S, Fujinami T, The American journal of physiology, 273, (6 Pt 2) H2811 - 6, 12 , Refereed
  • Coronary disease-prone behavior among Japanese men: job-centered lifestyle and social dominance. Type A Behavior Pattern Conference., Hayano J, Kimura K, Hosaka T, Shibata N, Fukunishi I, Yamasaki K, Mono H, Maeda S, American heart journal, 134, (6) 1029 - 1036, 12 , Refereed
  • Stability over time of circadian rhythm of variability of heart rate in patients with stable coronary artery disease., Hayano J, Jiang W, Waugh R, O'Connor C, Frid D, Blumenthal JA, American heart journal, 134, (3) 411 - 418, 09 , Refereed
  • Simulated analysis of method to calculate HF power in the power spectral density function of heart rate variability, Yasufumi Mizuno, Kiyoko Yokoyama, Seiichirou Sakata, Junichiro Hayano, Kazuyuki Takata, Japanese Journal of Medical Electronics and Biological Engineering, 35, 288 - 296, 01 01 , The power of the high-frequency (HF) region in the power spectral density function of heart rate variability has been recognized as an indicator of parasympathetic nervous system activity and is expected to be applicable as an evaluation parameter not only for the autonomic nervous system but also for mental and physical workload. To quantify HF power in accordance with the power spectral density (PSD) estimated by Fast Fourier Transform (FFT) or autoregressive model, several kinds of different methods have been suggested. These methods, for example, calculation of the PSD area from 0.15 Hz to 0.5 Hz, calculation of the area of the specific band width around the HF component and that utilizing the peak value of the HF component, do not always yield the same result in the tendency of HF power. To evaluate the performance of these methods quantitatively, simulation data were induced and the 'error rate' of each method was calculated and compared. The error rate showed that the method by Which PSD was estimated by FFT and the HF power calculated by the area of specific band width around the HF component was robust against noise and was effective in measuring HF power in the spontaneous breathing condition.
  • Biological Significance of Heart Rate Variability, J. Hayano, A. Okada, F. Yasuma, Japanese Journal of Artificial Organs, 25, 870 - 880, 12 01
  • Analysis of autonomous nerve response to tilt test by new HRV parameters, Masanori Moyoshi, Kiyoko Yokoyama, Yosaku Watanabe, Kazuyuki Takata, Seiji Mukai, Akiyoshi Okada, Jun Ichiro Hayano, Japanese Journal of Medical Electronics and Biological Engineering, 34, 161 - 170, 08 05 , In this study, the parameters obtained from the impulse response function in the time domain are proposed as new pamameters for evaluation of HRV (heart rate variability). The impulse response function is estimated from the autoregressive model by which the R R interval time series is expressed. HRV during graded head-up tilt was analyzed using the parameters, ARV, TP, heart rate, CV(R-R), and a power spectrum density function. RII, power, time constant, and settling time were obtained from the impulse response function. The RHI is the summation of the impulse response function during the transient decreasing of the function. The power is the average value of the square of the impulse response function of the maximum settling time. The time constant is the time to reach the output value of the system when stimulation is input to 1/c or less. The settling time is the time for the value of the impulse response function to become .0.1 or less. ARV expresses the irregularity of the time series, TP evaluates the adjustment function of the system. The subjects were the healthy males aged 19 to 27 years old. The tilt angle was 0, 20, 30, 45, 60, 90, and 0 degrees, and it was changed, respectively, every four minutes. As a result, RH1, power and TP showed a high correlation between LF/HE, that is, the index of sympathetic nerve activity. ARV exhibited a high correlation between HF, that is, the index of the parasympathetic nerve. It was possible to analyze the autonomous nerve response by TP, ARV, RHI and the power of the impulse response function. With these parameters, the realization of a simple, portable autonomous nerve response analysis device targeting real-time, non-stationary data is expected.
  • Respiratory sinus arrhythmia. A phenomenon improving pulmonary gas exchange and circulatory efficiency., Hayano J, Yasuma F, Okada A, Mukai S, Fujinami T, Circulation, 94, (4) 842 - 847, 08 , Refereed
  • Effect of slowed respiration on cardiac parasympathetic response to threat., Sakakibara M, Hayano J, Psychosomatic medicine, 58, (1) 32 - 37, 01 , Refereed
  • Association between type A behavior pattern and coronary artery spasm in Japanese patients., Hori R, Suzuki T, Hayano J, International journal of behavioral medicine, 3, (3) 221 - 232, Refereed
  • Autonomic dysfunction in hemodialysis patients with persistent hypotension., Takahashi H, Matsuo S, Toriyama T, Kawahara H, Hayano J, Nephron, 72, (3) 418 - 423, Refereed
  • Assessment of autonomic function in myotonic dystrophy by spectral analysis of heart-rate variability., Inoue K, Ogata H, Matsui M, Hayano J, Miyake S, Kumashiro M, Kuno M, Tokonami F, Aii H, Akatsu J, Journal of the autonomic nervous system, 55, (1-2) 131 - 134, 10 , Refereed
  • Assessment of autonomic function in traumatic quadriplegic and paraplegic patients by spectral analysis of heart rate variability., Inoue K, Ogata H, Hayano J, Miyake S, Kamada T, Kuno M, Kumashiro M, Journal of the autonomic nervous system, 54, (3) 225 - 234, 09 , Refereed
  • Lesser vagal withdrawal during isometric exercise with age., Taylor JA, Hayano J, Seals DR, Journal of applied physiology (Bethesda, Md. : 1985), 79, (3) 805 - 811, 09 , Refereed
  • 'Non-hypotensive' hypovolaemia reduces ascending aortic dimensions in humans., Taylor JA, Halliwill JR, Brown TE, Hayano J, Eckberg DL, The Journal of physiology, 483 ( Pt 1), 289 - 298, 02 , Refereed
  • A study of the clinical effect and its mechanism of the diazepam infusion sleeping therapy, T. Yamamoto, T. Takeuchi, K. Fukushima, M. Ando, J. Hayano, T. Kuboki, H. Suematsu, Japanese Journal of Psychosomatic Medicine, 35, 273 - 279, 01 01 , We developed diazepam infusion sleeping therapy (DIST) that was completed by reforming diazepam sedation threshold test which had been developed to estimate the anxiety of patients objectively and quantitatively. We have applied this therapeutic method to clinical use. As the result, we have obtained some knowledge. The results obtained were as follows: (1) The diseases that DIST was very effective for were vegitative dystonia, generalized anxiety disorder, panic disorder etc. (n = 30). The diseases that DIST was effective for were generalized anxiety disorder, panic disorder, depression, vegitative dystonia etc. (n = 50). The diseases that was ineffective for were generalized anxiety disorder, depression, anorexia nervosa, mesencephalosis etc. (n = 42). (2) On the clinical effect, more diazepam was required in the effective group and the very effective group compared with the ineffective group significantly (p < 0.05, n = 92). (3) The diazepam dosage of DIST was significantly higher in the IV area of CMI (Cornell Medical Index) compared with the I or II or III area of CMI (p < 0.05, n = 78). (4) Concerning the vital sign, the blood pressure decreased significantly at the sleeping point and after 30 minutes of DIST. The pulse and the respiratory rate increased significantly at the sleeping point of DIST (p < 0.05, n = 44). (5) Concerning the autonomic nerve function, there was no significant difference in the value of coefficient of component variance (CCV) before and after DIST. But, the LF (low frequent)/HF (high frequent) component, which can be an index of the domination of the sympathetic nerve activity to the parasympathetic nerve activity, was decreased on the next day after DIST and six days after DIST compared with the LF/HF component before DIST significantly (p < 0.05, n = 14). (6) MAS (Manifest Anxiety Scale) score was decreased significantly in six days after DIST compared with the score before DIST (p < 0.05, n = 14). As mentioned above, DIST seemed to be a very effective therapy to diminish the clinical signs and symptoms (especially anxiety state) of psychosomatic diseases.
  • Heart rate and blood pressure variabilities during graded head-up tilt., Mukai S, Hayano J, Journal of applied physiology (Bethesda, Md. : 1985), 78, (1) 212 - 216, 01 , Refereed
  • Assessment of frequency shifts in R-R interval variability and respiration with complex demodulation., Hayano J, Taylor JA, Mukai S, Okada A, Watanabe Y, Takata K, Fujinami T, Journal of applied physiology (Bethesda, Md. : 1985), 77, (6) 2879 - 2888, 12 , Refereed
  • [Periodical blood pressure variation during cardiopulmonary bypass--effects of cervicothoracic epidural anesthesia and phentolamine]., Sasano H, Sasano N, Ishida S, Oda N, Miura M, Baba E, Yamada M, Moriya T, Takamiya T, Hayano J, Masui. The Japanese journal of anesthesiology, 43, (10) 1454 - 1460, 10 , Refereed
  • Effects of respiratory interval on vagal modulation of heart rate., Hayano J, Mukai S, Sakakibara M, Okada A, Takata K, Fujinami T, The American journal of physiology, 267, (1 Pt 2) H33 - 40, 07 , Refereed
  • Effect of relaxation training on cardiac parasympathetic tone., Sakakibara M, Takeuchi S, Hayano J, Psychophysiology, 31, (3) 223 - 228, 05 , Refereed
  • Body image and self image (2nd report) - Low self-esteem and over-estimation of body weight, S. Takeuchi, J. Hayano, R. Hori, S. Mukai, Japanese Journal of Psychosomatic Medicine, 33, 697 - 703, 12 01
  • Body image in Japanese junior-high-school students - Impact of slender images mediated by mass communication, S. Takeuchi, J. Hayano, R. Hori, S. Mukai, T. Fujinami, Japanese Journal of Psychosomatic Medicine, 33, 691 - 695, 12 01
  • Relation of cardiovascular responses to mental stress and cardiac vagal activity in coronary artery disease., Jiang W, Hayano J, Coleman ER, Hanson MW, Frid DJ, O'Connor C, Thurber D, Waugh RA, Blumenthal JA, The American journal of cardiology, 72, (7) 551 - 554, 09 , Refereed
  • Regulation of QT interval during postural transitory changes in heart rate in normal subjects., Yamada A, Hayano J, Horie K, Ieda K, Mukai S, Yamada M, Fujinami T, The American journal of cardiology, 71, (11) 996 - 998, 04 , Refereed
  • Continuous assessment of hemodynamic control by complex demodulation of cardiovascular variability., Hayano J, Taylor JA, Yamada A, Mukai S, Hori R, Asakawa T, Yokoyama K, Watanabe Y, Takata K, Fujinami T, The American journal of physiology, 264, (4 Pt 2) H1229 - 38, 04 , Refereed
  • Single administration of captopril and combined use with beta-blocker and/or thiazide diuretic in the treatment of essential hypertension., Yoneda S, Kako T, Koketsu M, Hayano J, Asakawa T, Fujinami T, Kato T, Angiology, 42, (11) 914 - 923, 11 , Refereed
  • Continuous-wave Doppler echocardiography for evaluating left ventricular performance--clinical significance of a new systolic time interval., Ohte N, Nakano S, Hashimoto T, Narita H, Hayano J, Fujinami T, Japanese circulation journal, 55, (5) 459 - 464, 05 , Refereed
  • Severity of coronary atherosclerosis correlates with the respiratory component of heart rate variability., Hayano J, Yamada A, Mukai S, Sakakibara Y, Yamada M, Ohte N, Hashimoto T, Fujinami T, Takata K, American heart journal, 121, (4 Pt 1) 1070 - 1079, 04 , Refereed
  • Body image and self image in 712 junior-high school students, S. Takeuchi, J. Hayano, T. Kamiya, R. Hori, S. Mukai, T. Fujinami, Japanese Journal of Psychosomatic Medicine, 31, 367 - 373, 01 01
  • Accuracy of assessment of cardiac vagal tone by heart rate variability in normal subjects., Hayano J, Sakakibara Y, Yamada A, Yamada M, Mukai S, Fujinami T, Yokoyama K, Watanabe Y, Takata K, The American journal of cardiology, 67, (2) 199 - 204, 01 , Refereed
  • Noninvasive evaluation of left ventricular performance with a new systolic time interval, the Q-V peak, and comparison with established systolic time intervals., Ohte N, Hashimoto T, Narita H, Takase R, Kobayashi K, Hayano J, Fujinami T, The American journal of cardiology, 66, (12) 1018 - 1020, 10 , Refereed
  • Coronary risk factors in angiographically defined patients with chest pain., Fujinami T, Hirata H, Hayano J, Ohte N, Kohketsu M, Hashimoto T, Japanese journal of medicine, 29, (5) 462 - 468, 09 , Refereed
  • Decreased magnitude of heart rate spectral components in coronary artery disease. Its relation to angiographic severity., Hayano J, Sakakibara Y, Yamada M, Ohte N, Fujinami T, Yokoyama K, Watanabe Y, Takata K, Circulation, 81, (4) 1217 - 1224, 04 , Refereed
  • Diurnal variations in vagal and sympathetic cardiac control., Hayano J, Sakakibara Y, Yamada M, Kamiya T, Fujinami T, Yokoyama K, Watanabe Y, Takata K, The American journal of physiology, 258, (3 Pt 2) H642 - 6, 03 , Refereed
  • Hemorheological effects of coenzyme Q10in patients with ischemic heart disease, Tadashi Kato, Shunki Yoneda, Toshio Kako, Masaaki Koketsu, Junichiro Hayano, Takao Fujinami, Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics, 21, 433 - 437, 01 01 , The effects of coenzyme Q10 (CoQ10) on blood rheology were studied in patients with ischemic heart disease. Twenty milligrams of C0Q10 was administrated per os three times daily (total dose 60 mg per day) for two months. Whole blood viscosity was measured at the shear rates of 37. 5, 75, 150 and 375 sec-1with a conplate type viscometer. Whole blood viscosity at each shear rate was decreased after administration of CoQio. Casson viscosity and yield shear stress were calculated using the Casson plot method from the ‘ blood viscosity at each shear rate. Yield shear stress was significantly lowered after admin-istration of CoQio, while Casson viscosity was not significantly changed. Both the hemo- starting- point and hemolysis end point represented by mOsm were determined by means of the coil plant centrifuge method. These parameters, which reflect osmotic fragility of erythrocytes, showed significant decreases after administration of CoQio. After the blood was diluted with a phosphate buffer solution, passage time through the Nuclepore membrane with a pore size of 5 ^m was measured 10 min after the in vitro administration of CoQ10 of 5 pg. This passage time was significantly shortened after administration of CoQio. There were no significant changes in hematocrit and fibrinogen after administration of CoQ10. These results show that administration of CoQio improves hemorheology in ischemic heart disease, and thus suggests that oxygen transport to heart muscle is increased by treatment of CoQ10. © 1990, The Japanese Society of Clinical Pharmacology and Therapeutics. All rights reserved.
  • Short- and long-term effects of cigarette smoking on heart rate variability., Hayano J, Yamada M, Sakakibara Y, Fujinami T, Yokoyama K, Watanabe Y, Takata K, The American journal of cardiology, 65, (1) 84 - 88, 01 , Refereed
  • Type A behavior pattern in Japanese employees: cross-cultural comparison of major factors in Jenkins Activity Survey (JAS) responses., Hayano J, Takeuchi S, Yoshida S, Jozuka H, Mishima N, Fujinami T, Journal of behavioral medicine, 12, (3) 219 - 231, 06 , Refereed
  • Type A behaviors pattern in panic disorders, H. Jozuka, J. Hayano, S. Yoshida, Japanese Journal of Psychosomatic Medicine, 28, 345 - 349, 01 01
  • [A multivariate autoregressive model of R-R intervals and blood pressure time series]., Watanabe Y, Yokoyama K, Takata K, Hayano J, Fujinami T, Iyo denshi to seitai kogaku. Japanese journal of medical electronics and biological engineering, 24, (7) 511 - 516, 12 , Refereed
  • [A study on experimental pancreatitis]., HAYANO J, [Hokkaido igaku zasshi] The Hokkaido journal of medical science, 36, 89 - 100, 02 , Refereed

Misc

  • Relationship between Subjective Assessment of Sleep Quality and Heart Rate Variability during Sleep, E. Yuda, Y. Yoshida, J. Hayano, 2018 IEEE International Conference on Consumer Electronics-Taiwan, ICCE-TW 2018,   2018 08 27 , © 2018 IEEE. Assessment of autonomic function during sleep is gathering attention as an indicator of sleep quality that is closer to subjective assessment than that from polysomnography or actigraphy. This study examined the relationships between subjective sleep quality assessment and heart rate variability (HRV) indices, particularly those derived from a new sleep index (Hsi) that we have recently developed to detect non-REM sleep. We studied 18 sets of nighttime ECGs and the responses to sleep inventory questionnaires obtained from 5 male workers. We observed that subjective quality was associated with sleep latency estimated by Hsi and with the length of time in bed excluding the period of non-REM sleep in these subjects.
  • ALLSTAR心拍変動ビッグデータ解析からみた日本人の老衰死率の地域差と健康指標の関連, 湯田恵美, 吉田豊, 木曽原昌也, 早野順一郎, 電子情報通信学会技術研究報告, 118,   2018 05 24
  • 眠気に伴う生理学的変化 心拍および脳波による検討, 湯田恵美, 吉田豊, 川嶋宏行, 山本浩彰, 田中春仁, 早野順一郎, 自動車技術会大会学術講演会講演予稿集(CD-ROM), 2018,   2018 05 21
  • Heart rate variability and cardiac diseases, Eiichi Watanabe, Ken Kiyono, Yoshiharu Yamamoto, Junichiro Hayano, Clinical Assessment of the Autonomic Nervous System,   2016 01 01 , © Springer Japan 2017. Heart rate variability (HRV) is a noninvasive methodology for evaluating the autonomic nervous system modulation of the sinoatrial node and to identify patients at risk of cardiac disorders. The contemporary therapeutic use for the HRV analysis is for risk stratification in patients with post-myocardial infarction or heart failure who are prone to have arrhythmic death and who would benefit from implantable cardioverter-defibrillators (ICDs). Although multiple HRV measurements have been developed to achieve a better risk stratification, the HRV measurements have been rarely tested to see whether they harbor a significant power to serve as a practical risk predictor. To date, the only reliable metric to predict the benefit from an ICD is a severely reduced ejection fraction; however, the predictive value of the ejection fraction is relatively low. Because of the high negative predictive value of the HRV, a combination with the ejection fraction may be helpful to identify candidates who are unlikely to benefit from ICD therapy. A more sophisticated risk approach that combines the HRV and other known clinical measures should be developed to provide accurate estimates of the risk to allow patients to make informed treatment decisions. Another requirement is to explore the novel HRV measurements for atrial fibrillation. The prevalence of atrial fibrillation rapidly increases among the aging population and is independently associated with a higher risk of ischemic strokes and excess mortality. The HRV measurements specific for atrial fibrillation may facilitate the risk stratification in such a high-risk population.
  • Respiratory sinus arrhythmia and entraining heartbeats with cheyne-stokes respiration: Cardiopulmonary works to be minimal by synchronizing heartbeats with breathing, Fumihiko Yasuma, Junichiro Hayano, Clinical Assessment of the Autonomic Nervous System,   2016 01 01 , © Springer Japan 2017. There are two types of interaction between heartbeats and respiration with different time scales. One is the well-known respiratory sinus arrhythmia (RSA) and another is entraining heartbeats with Cheyne-Stokes respiration (CSR). The latter is the cyclical fluctuation with the clustering heartbeats during the hyperventilation phase of CSR and their scattering during the apnea/hypopnea phase, which we call the Entrainment with CSR. The wisdom of the body for maintaining the homeostasis efficiently could be achieved by synchronizing heartbeats with breathing and consequently by saving the cardiopulmonary works. Analogous to that the RSA benefits the pulmonary gas exchange, we have hypothesized that the Entrainmentwith CSR might function to supply “effective” heartbeats during the hyperventilation phase and save “ineffective” heartbeats during the apneic/hypopneic phase to benefit the pulmonary gas exchange according to our previous investigations on the pulmonary gas exchange and RSA, the control of RSA and respiratory muscles during hypercapnia and hypoxia, the role of vagal nerve on RSA and respiratory muscles, and our clinical experiences in heart failure and atrial fibrillation. The concept that the RSA and Entrainment with CSR would serve for the cardiopulmonary works to be minimal by synchronizing heartbeats with breathing would be tested in the future.
  • Heart rate variability (hrv) and sympathetic nerve activity, Ken Kiyono, Junichiro Hayano, Eiichi Watanabe, Yoshiharu Yamamoto, Clinical Assessment of the Autonomic Nervous System,   2016 01 01 , © Springer Japan 2017. The available epidemiological and clinical data implicate increased sympathetic nervous system activity in increased cardiovascular morbidity and mortality and show that it has strong predictive power for mortality and cardiovascular events. Analysis of heart rate variability (HRV) has been widely used as a noninvasive assessment tool for autonomic nervous system function, and results show that reduced and/or abnormal HRV is associated with an increased risk of mortality in cardiac patients such as patients after acute myocardial infarction and patients with congestive heart failure. However, most indices derived from HRV primarily reflect vagal function. In contrast, few indices have been suggested as markers of sympathetic nervous system activity. This chapter reviews characteristics of HRV that have been proposed as potential markers of cardiac sympathetic activity, such as (in the frequency domain) low-frequency (LF) power, short-term scaling exponent, and non-Gaussianity index. While there is no widely accepted and well-tested HRV-based index of cardiac sympathetic activity, we discuss the key issues for the assessment of cardiac sympathetic activity based on HRV analysis.
  • Introduction to heart rate variability, Junichiro Hayano, Clinical Assessment of the Autonomic Nervous System,   2016 01 01 , © Springer Japan 2017. Beat-to-beat intervals of cardiac sinus rhythm are not constant but show complex and continuous fluctuations called heart rate variability (HRV). Because HRV disappears with cardiac denervation by complete autonomic blockades or cardiac transplantation, HRV is thought to originate from the brain and to transfer to the heart through the autonomic nervous system. HRV includes a plenty of information not only about autonomic neural cardiac regulations but also about health state and hazard that are captured by the brain. To extract information that meets with particular purposes, various methods have been developed for the analysis of HRV. This chapter explains the basic mechanisms generating HRV and introduces the purposes and corresponding methods for HRV analyses.

Books etc

  • Big data technologies and applications, Emi Yuda, Yuki Furukawa, Yutaka Yoshida, Junichiro Hayano, Joint Work, ALLSTAR Project Investigators. Association between regional difference in heart rate variability and inter-prefecture ranking of healthy life expectancy: ALLSTAR big data project in Japan, Springer Nature,   2017
  • Clinical assessment of the autonomic nervous system, Junichiro Hayano, Joint Editor, Introduction to heart rate variability, Springer Nature,   2016

Conference Activities & Talks

  • Sleep stage classification by combination of actigraphic and heart rate signals, Junichiro Hayano, Emi Yuda, Yutaka Yoshida, 2017 IEEE International Conference on Consumer Electronics - Taiwan, ICCE-TW 2017,   2017 07 25 , © 2017 IEEE. This paper presents the performance of sleep stage classification by combination of actigraphic and heart rate signals. We studied 40,643 epochs (length 3 min) of polysomnographic data in 289 subjects. Body movement indices derived from actigraphic data and autonomic functional indices from heart rate variability were useful for discriminating between non-REM sleep and waking/REM sleep at 76.9% sensitivity and 74.5% specificity and between REM sleep and waking at 77.2% sensitivity and 72.3% specificity.
  • Fast algorithm of long-range cross-correlation analysis using Savitzky-Golay detrending filter and its application to biosignal analysis, Yutaka Tsujimoto, Yuki Miki, Eiichi Watanabe, Junichiro Hayano, Yoshiharu Yamamoto, Taishin Nomura, Ken Kiyono, 2017 International Conference on Noise and Fluctuations, ICNF 2017,   2017 07 19 , © 2017 IEEE. To evaluate long-range cross-correlated behavior observed in bivariate time series, detrended cross-correlation analysis (DCCA) was proposed. In the DCCA, trends embedded in each time series are eliminated via piecewise least-squares polynomial fitting in the same way as the detrended fluctuation analysis (DFA). In this paper, as an improved variant of DCCA, we propose a DCCA method using the Savitzky-Golay detrending filters and its fast implementation algorithm. In addition, as an application of our method, we analyze the cardiorespiratory interaction.
  • Characteristics of basal heart rate during daily life: Relationships with age, sex, and mean heart rate, Junichiro Hayano, Yutaka Yoshida, Emi Yuda, ACM International Conference Proceeding Series,   2017 05 23 , Vast heart rate (HR) data during daily activities are being accumulated with widespread use of wearable sensors. To interpret the meaning of these HR data, the reference point of HR in individual subject is required. Although resting HR has been used for this purpose, the definition of resting HR has not been established and particularly, the effects of time of the day (circadian rhythm) on resting HR have not been considered. One of the other candidates for the reference point may be basal HR, i.e., the lowest HR in the day. In the present study, we therefore investigated the characteristics of basal HR by examining the effects of age and sex on basal HR and the occurrence time of basal HR during 24 h in 113,341 males and 140,332 females extracted from a 24-h Holter ECG database of the Allostatic State Mapping by Ambulatory ECG Repository (ALLSTAR). Although basal HR decreases with age until 20 yr old in both sexes, it increases slightly with advancing age thereafter. Although the clock time to reach basal HR appears between 02 and 05 h on average, it shows progress or delay depending on the time of life. The difference between 24-h mean and basal HR decrease linearly with age, suggesting that age-dependent decline in the increases in HR with daily activities can be detected by using basal HR as the reference point.
  • Criticality and universality in healthy heart rate dynamics, Zbigniew R. Struzik, Ken Kiyono, Junichiro Hayano, Seiichiro Sakata, Shin Kwak, Yoshiharu Yamamoto, AIP Conference Proceedings,   2005 08 25 , Methodologies originally developed in the field of statistical physics of complex phenomena have been proven to provide new insights into the modeling, description and understanding of the human heart rate regulatory system. Recent studies have shown the heart rate control system to maintain universality properties characteristic of physical systems exhibiting far-from-equilibrium, critical state-like dynamics. Simultaneously, heart rate regulation has been shown to display correlation properties of antagonist dynamics involving antagonist actors, pertinent to some far-from-equilibrium systems. We discuss the range of validity and breakdown scenarios of the universal properties in heart rate regulation leading to the diagnostic capability and also to new challenges for both analysis methods and up-to-date simulation models. © 2005 American Institute of Physics.
  • Probing temporal correlation in ventricular interbeat intervals during atrial fibrillation with local continuous DFA, Stefan Heinrichs, Zbigniew R. Struzik, Zbigniew R. Struzik, Junichiro Hayano, Yoshiharu Yamamoto, Yoshiharu Yamamoto, Proceedings of SPIE - The International Society for Optical Engineering,   2004 09 13 , Using the method of local Continuous Detrended Fluctuation Analysis (CDFA) we analyze the correlations of ventricular interbeat intervals of patients with Atrial Fibrillation (AF). CDFA yields a local Holder exponent h for a neighborhood around each point in the time series by determining the scaling of fluctuations with window size after detrending. We compare the histograms of Hölder exponents for original data with those of randomly shuffled data and find some correlations not only in long-range windows but also at short time scales where interbeat intervals during AF have been believed to be random in nature. Furthermore, we find unique temporal correlation structures to occur only in the heart rate of patients who were in the survivor group when a follow up was conducted at least one year after data acquisition. We conclude that ventricular interbeat intervals during AF contain richer information than previously considered and the study of the local correlations may be useful in predicting mortality of the patients.
  • Evidence for the origins and breakdown of 1/f noise in heart rate, Zbigniew R. Struzik, Zbigniew R. Struzik, Junichiro Hayano, Seiichiro Sakata, Shin Kwak, Yoshiharu Yamamoto, Yoshiharu Yamamoto, Proceedings of SPIE - The International Society for Optical Engineering,   2004 09 13 , We present the first systematic evidence for the origins and breakdown of I/f scaling in human heart rate. We confirm a previously posed conjecture that I/f scaling in heart rate is caused by the intricate balance between antagonistic activity of sympathetic (SNS) and parasympathetic (PNS) nervous systems. We demonstrate that modifying the relative importance of either of the two branches leads to a substantial decrease of I/f scaling. In particular, the relative PNS suppression both by congestive heart failure (CHF) and by the parasympathetic blocker atropine results in a substantial increase in the Hurst exponent H and a shift of the multifractal spectrum f(α) from 1/f towards random walk scaling 1/f2. Surprisingly, we observe a similar breakdown in the case of relative and neurogenic SNS suppression by primary autonomic failure (PAF). Further, we observe an intriguing interaction between multifractality of heart rate and absolute variability. While it is generally believed that lower absolute variability results in monofractal behaviour, as has been demonstrated both for CHF and the parasympathetic blockade, in PAF patients we observe conservation of multifractal properties at substantially reduced absolute variability to levels closer to CHF. This novel and intriguing result leads us to the conjecture that the multifractality of the heart rate can be traced back to the intrinsic dynamics of the parasympathetic nervous system.
  • Proceedings of the 3rd Japanese Annual Conference on Chronocardiology and Hypertension: Preface, Hiroshi Hayashi, Junichiro Hayano, Clinical and Experimental Hypertension,   2003 04 01
  • Increased serum triglyceride clearance, unchanged cholesteryl ester transfer protein activity, and elevated HDL cholesterol during treatment of hypertriglyceridemia with bezafibrate, Reiko Ikeuchi, Nagahiko Sakuma, Takeshi Hibino, Takaaki Sato, Yoshinobu Kamiya, Masanobu Kawaguchi, Nobuyuki Ohte, Junichiro Hayano, Current Therapeutic Research,   1994 01 01 , The effects of bezafibrate on lipid metabolism were evaluated in 22 patients with type IIb or type IV hypertriglyceridemia. Bezafibrate 400 mg/d was administered for 8 weeks. A fat emulsion tolerance test (FETT) to evaluate serum triglyceride (TG) clearance (fractional removal rate = K2) and measurement of cholesteryl ester transfer protein (CETP) activity were performed before bezafibrate administration and after the 8-week treatment period using blood samples obtained after overnight fasting. Statistically significant reductions were observed in serum TG (P < 0.01), apolipoprotein (apo) B (P < 0.01), apo C-II (P < 0.05), apo C-III (P < 0.001), and apo E (P < 0.05). Significant increases were seen in high-density lipoprotein cholesterol (HDL-C) (P < 0.001), apo A-I (P < 0.001), and apo A-II (P < 0.001). K2was significantly elevated (P < 0.001). CETP activity declined slightly, but the change was not statistically significant. Strong positive correlations were evident between the absolute value of increased K2and the increase in both HDL-C (r = .67, P < 0.005) and apo A-I (r = .53, P < 0.05). It can be inferred from these findings that the bezafibrate-induced reduction in serum TG and increase in HDL-C observed in patients with hypertriglyceridemia arise from an acceleration in TG-rich lipoprotein metabolism. © 1994 Excerpta Medica, Inc. All rights reserved.

Patents

  • 特願2015-049863, 特開2016-168188
  • 特願2008-217131, 特開2010-051387
  • 特願2002-300013, 特開2004-129979
  • 特願2002-300013, 特開2004-129979, 特許第4187498号
  • 特願2002-171136, 特開2004-016248
  • 特願2002-171136, 特開2004-016248, 特許第3806371号
  • 特願2002-024056, 特開2003-047601
  • 特願2001-140180, 特開2002-330935
  • 特願2001-140180, 特開2002-330935, 特許第4679755号
  • 特願2001-099985, 特開2002-291710
  • 特願2001-099985, 特開2002-291710, 特許第4731031号
  • 特願2000-351713, 特開2002-153432
  • 特願2000-351713, 特開2002-153432, 特許第4693228号


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