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HIGUCHI Tsunehiko

FacultyGraduate School of Pharmaceutical Sciences Department of Bioorganic-inorganic Chemistry
PositionProfessor
Mailhiguchiphar.nagoya-cu.ac.jp
HomepageURLhttp://www.phar.nagoya-cu.ac.jp/hp/ysk/index.html
Birthday
Last Updated :2019/08/02

Researcher Profile and Settings

Degree

  • Ph D, The University of Tokyo

Association Memberships

  • The Pharmaceutical Society of Japan
  • The Chemical Society of Japan
  • Society for Free Radical Research JAPAN
  • The American Chemical Society

Committee Memberships

  •   1988 04  - 現在, The Chemical Society of Japan, member
  •   1985 08  - 現在, The Pharmaceutical Society of Japan, member

Research Activities

Research Areas

  • Basic chemistry, Organic chemistry, bioorganic chemistry
  • Basic chemistry, Inorganic chemistry, bioinorganic chemistry
  • Pharmacy, Drug development chemistry
  • Pharmacy, Chemical pharmacy

Published Papers

  • Methylene chain ruler for evaluating the regioselectivity of a substrate-recognising oxidation catalyst., Teramae S, Kito A, Shingaki T, Hamaguchi Y, Yano Y, Nakayama T, Kobayashi Y, Kato N, Umezawa N, Hisamatsu Y, Nagano T, Higuchi T, Chemical communications (Cambridge, England), 55, (58) 8378 - 8381, 07 , Refereed
  • Photocontrol of Peptide Function: Backbone Cyclization Strategy with Photocleavable Amino Acid, Umezawa, Naoki; Noro, Yuka; Ukai, Kazuhiro; Kato, Nobuki; Higuchi, Tsunehiko, ChemBioChem, 12, (11) 1694 - 1698, 07 , Refereed
  • Stable Iron Porphyrin Intramolecularly Coordinated by Alcoholate Anion: Synthesis and Evaluation of Axial Ligand Effect of Alcoholate on Spectroscopy and Catalytic Activity., Shirakawa Y, Yano Y, Niwa Y, Inabe K, Umezawa N, Kato N, Hisamatsu Y, Higuchi T, Inorganic chemistry, 58, (7) 4268 - 4274, 04 , Refereed
  • Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1, Mimasu, Shinya; Umezawa, Naoki; Sato, Shin; Higuchi, Tsunehiko; Umehara, Takashi; Yokoyama, Shigeyuki, Biochemistry, 49, (30) 6494 - 6503, 08 , Refereed
  • Effect of the o-Acetamido Group on pH-Dependent Light Emission of a 3-Hydroxyphenyl-Substituted Dioxetane Luminophore., Hisamatsu Y, Fukiage T, Honma K, Balia AG, Umezawa N, Kato N, Higuchi T, Organic letters, 21, (5) 1258 - 1262, 03 , Refereed
  • Facile synthesis of peptide-porphyrin conjugates: Towards artificial catalase, Umezawa, Naoki; Matsumoto, Nobuyoshi; Iwama, Shinsuke; Kato, Nobuki; Higuchi, Tsunehiko, Bioorg. Med. Chem., 18, (17) 6340 - 6350, 09 , Refereed
  • Repulsive/attractive interaction among compact DNA molecules as judged through laser trapping: difference between linear- and branched-chain polyamines, Kashiwagi Yusuke, Nishio Takashi, Ichikawa Masatoshi, Shew Chwen-Yang, Umezawa Naoki, Higuchi Tsunehiko, Sadakane Koichiro, Yoshikawa Yuko, Yoshikawa Kenichi, COLLOID AND POLYMER SCIENCE, 297, (3) 397 - 407, 03 , Refereed
  • Spectroscopic and Mechanistic Studies on Oxidation Reactions Catalyzed by the Functional Model SR Complex for Cytochrome P450: Influence of Oxidant, Substrate, and Solvent, Hessenauer-Ilicheva, Natalya; Franke, Alicja; Wolak, Maria; Higuchi, Tsunehiko; van Eldik, Rudi, Chem.Eur. J., 15, (45) 12447 - 12459, 11 , Refereed
  • Distinct modulation of group I ribozyme activity among stereoisomers of a synthetic pentamine with structural constraints., Gulshan MA, Tsuji K, Matsumura S, Higuchi T, Umezawa N, Ikawa Y, Biochemical and biophysical research communications, 504, (4) 698 - 703, 10 , Refereed
  • Turn-on fluorescent probe with visible light excitation for labeling of hexahistidine tagged protein, Kamoto, Mie; Umezawa, Naoki; Kato, Nobuki; Higuchi, Tsunehiko, Bioorg. Med. Chem. Lett., 19, (8) 2285 - 2288, 04 , Refereed
  • Hydrogen sulfide bypasses the rate-limiting oxygen activation of heme oxygenase, oshitaka Matsui, Ryota Sugiyama, Kenta Sakanashi, Yoko Tamura, Masaki Iida, Yukari Nambu, Tsunehiko Higuchi, Makoto Suematsu, Masao Ikeda-Saito, Journal of Biological Chemistry, 293, (43) 16931 - 16939, 10 , Refereed
  • Inhibition of γ-Secretase Activity by Helical β-Peptide Foldamers, Imamura, Yuki; Watanabe, Naoto; Umezawa, Naoki; Iwatsubo, Takeshi; Kato, Nobuki; Tomita, Taisuke; Higuchi, Tsunehiko, J. Am. Chem. Soc., 131, (21) 7353 - 7359, 06 , Refereed
  • Design and synthesis of a 4-aminoquinoline-based molecular tweezer that recognizes protoporphyrin IX and iron(iii) protoporphyrin IX and its application as a supramolecular photosensitizer, Yosuke Hisamatsu, Naoki Umezawa, Hirokazu Yagi, Koichi Kato, Tsunehiko Higuchi, Chemical Science, 9, (38) 7455 - 7467, 10 , Refereed
  • Extreme rate acceleration by axial thiolate coordination on the isomerization of endoperoxide catalyzed by iron porphyrin: relevance to prostaglandin H2 isomerase catalysis, Yamane, Takehiro; Makino, Kohei; Umezawa, Naoki; Kato, Nobuki; Higuchi, Tsunehiko, Angew. Chem. Int. Ed., 47, (34) 6438 - 6440, Refereed
  • Potent Antimalarial Activity of Two Arenes Linked with Triamine Designed To Have Multiple Interactions with Heme, Yosuke Sakata, Kosuke Yabunaka, Yuko Kobayashi, Hirohisa Omiya, Naoki Umezawa, Hye-Sook Kim, Yusuke Wataya, Yoshimi Tomita, Yosuke Hisamatsu, Nobuki Kato, Hirokazu Yagi, Tadashi Satoh, Koichi Kato, Haruto Ishikawa, Tsunehiko Higuchi, ACS Medicinal Chemistry Letters, 9, (10) 980 - 985, 10 , Refereed
  • Branched-Chain Polyamine Found in Hyperthermophiles Induces Unique Temperature-Dependent Structural Changes in Genome-Size DNA, Takashi Nishio, Yuko Yoshikawa, Wakao Fukuda, Naoki Umezawa, Tsunehiko Higuchi, Shinsuke Fujiwara, Tadayuki Imanaka, Kenichi Yoshikawa, ChemPhysChem, 19, (18) 2299 - 2304, 09 , Refereed
  • Array-based fluorescence assay for serine/threonine kinases using specific chemical reaction, Akita, Shoji; Umezawa, Naoki; Kato, Nobuki; Higuchi, Tsunehiko, Bioorg. Med. Chem., 16, (16) 7788 - 7794, 08 15 , Refereed
  • Comparative study of polyethylene polyamines as activator molecules for a structurally unstable group I ribozyme., Gulshan MA, Matsumura S, Higuchi T, Umezawa N, Ikawa Y, Bioscience, biotechnology, and biochemistry, 82, (8) 1404 - 1407, 08 , Refereed
  • A Versatile Strategy for the Synthesis of Crown Ether-Bearing Heterocycles: Discovery of Calcium-Selective Fluoroionophore, Aoki, Yuko; Umezawa, Naoki; Asano, Yuko; Hatano, Keiichiro; Yano, Yuki; Kato, Nobuki; Higuchi, Tsunehiko, Bioorg. Med. Chem., 15, (22) 7108 - 7115, 11 15 , Refereed
  • Novel Probes Showing Specific Fluorescence Enhancement on Binding to Hexahistidine Tag, Kamoto, Mie; Umezawa, Naoki; Kato, Nobuki; Higuchi, Tsunehiko, Chem.-Eur. J., 14, (26) 8004 - 8012, Refereed
  • A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model, Naomi Tsuburaya, Kengo Homma, Tsunehiko Higuchi, Andrii Balia, Hiroyuki Yamakoshi, Norio Shibata, Seiichi Nakamura, Hidehiko Nakagawa, Shin-ichi Ikeda, Naoki Umezawa, Nobuki Kato, Satoshi Yokoshima, Masatoshi Shibuya, Manabu Shimonishi, Hirotatsu Kojima, Takayoshi Okabe, Tetsuo Nagano, Isao Naguro, Keiko Imamura, Haruhisa Inoue, Takao Fujisawa, Hidenori Ichijo, Nature Communications, 9, (1) , 07 , Refereed
  • Enhanced Catalase-like Activity of Manganese Salen Complexes in Water: Effect of Three-dimensionally Fixed Auxiliary, Watanabe, Yoritada; Namba, Azusa; Umezawa, Naoki; Kawahata, Masatoshi; Yamaguchi, Kentaro; Higuchi, Tsunehiko, Chem. Commun., (47) 4958 - 4960, 12 , Refereed
  • Biogenic triamine and tetraamine activate core catalytic ability of Tetrahymena group I ribozyme in the absence of its large activator module, Mst Ara Gulshan, Md Motiar Rahman, Shigeyoshi Matsumura, Tsunehiko Higuchi, Naoki Umezawa, Yoshiya Ikawa, Biochemical and Biophysical Research Communications, 496, (2) 594 - 600, 02 , Refereed
  • Selective recognition and detection of biomacromolecules utilizing chemical property of amino acid or peptide, Umezawa Naoki, Akita Shoji, Kamoto Mie, Higuchi Tsunehiko, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 127, (12) 1915 - 1925, 12 , Refereed
  • Active site geometry of a novel aminopropyltransferase for biosynthesis of hyperthermophile-specific branched-chain polyamine, Ryota Hidese, Ka Man Tse, Seigo Kimura, Eiichi Mizohata, Junso Fujita, Naoki Umezawa, Tsunehiko Higuchi, Tadayuki Imanaka, Tsuyoshi Inoue, Shinsuke Fujiwara, FEBS Journal, 284, (21) 3684 - 3701, 11 , Refereed
  • Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1, Yuichi Amano, Masaki Kikuchi, Shin Sato, Shigeyuki Yokoyama, Takashi Umehara, Naoki Umezawa, Tsunehiko Higuchi, Bioorganic and Medicinal Chemistry, 25, (9) 2617 - 2624, 05 , Refereed
  • Role of Thiolate Ligand in Spin State and Redox Switching in the Cytochrome P450 Catalytic Cycle, Hiroshi Suzuki, Kanako Inabe, Yoshinori Shirakawa, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi, Inorganic Chemistry, 56, (8) 4245 - 4248, 04 , Refereed
  • Activation of lysine-specific demethylase 1 inhibitor peptide by redox-controlled cleavage of a traceless linker, Yuichi Amano, Naoki Umezawa, Shin Sato, Hisami Watanabe, Takashi Umehara, Tsunehiko Higuchi, Bioorganic {?&} Medicinal Chemistry, 25, (3) 1227 - 1234, 02 , Refereed
  • Design, Synthesis and Evaluation of New Type of L-Amino Acids Containing Pyridine Moiety as Nitric Oxide Synthase Inhibitor, Ijuin, Ryosuke; Umezawa, Naoki; Higuchi, Tsunehiko, Bioorg. Med. Chem., 14, (10) 3563 - 3570, 05 , Refereed
  • Naturally occurring branched-chain polyamines induce a crosslinked meshwork structure in a giant DNA, Akira Muramatsu, Yuta Shimizu, Yuko Yoshikawa, Wakao Fukuda, Naoki Umezawa, Yuhei Horai, Tsunehiko Higuchi, Shinsuke Fujiwara, Tadayuki Imanaka, Kenichi Yoshikawa, Journal of chemical Physics, 145, (23) , 12 , Refereed
  • On-Bead Fluorescence Assay for Serine/Threonine Kinases, Akita, Shoji; Umezawa, Naoki; Higuchi, Tsunehiko, Org. Lett., 7, (25) 5565 - 5568, 12 , Refereed
  • Design of new extraction surfactants for membrane proteins from peptide-gemini surfactants (PG-surfactants), Masahide Shibata, Shuhei Koeda, Tomoyasu Noji, Keisuke Kawakami, Yuya Ido, Yuichi Amano, Naoki Umezawa, Tsunehiko Higuchi, Takehisa Dewa, Shigeru Itoh, Nobuo Kamiya, and Toshihisa Mizuno, Bioconjugate Chemistry, 27, (10) 2469 - 2479, 10 , Refereed
  • Evaluation of 3-Substituted Arginine Analogs as Selective Inhibitors of Human Nitric Oxide Synthase Isozymes, Ijuin, Ryosuke; Umezawa, Naoki; Nagai, Shin-ichi; Higuchi,Tsunehiko, Bioorg. Med. Chem. Lett., 15, (11) 2881 - 2885, 06 , Refereed
  • Structurally Diverse Polyamines: Solid-Phase Synthesis and Interaction with DNA, Naoki Umezawa, Yuhei Horai, Yuki Imamura, Makoto Kawakubo, Mariko Nakahira, Nobuki Kato, Akira Muramatsu, Yuko Yoshikawa, Kenichi Yoshikawa, Tsunehiko Higuchi, ChemBioChem, 16, (12) 1811 - 1819, 08 , Refereed
  • Unique Oxidation Reaction of Amides with Pyridine-N-oxide Catalyzed by Ruthenium Porphyrin - Direct Oxidative Conversion of N-Acyl-L-prolines to N-Acyl-L-glutamates, Ito, Rina; Umezawa, Naoki; Higuchi, Tsunehiko, J. Am. Chem. Soc., 127, (3) 834 - 835, 01 , Refereed
  • Identification of a novel aminopropyltransferase involved in the synthesis of branched-chain polyamines in hyperthermophiles, Kazuma Okada, Ryota Hidese, Wakao Fukuda, Masaru Niitsu, Koichi Takao, Yuhei Horai, Naoki Umezawa, Tsunehiko Higuchi, Tairo Oshima, Yuko Yoshikawa, Tadayuki Imanaka, Shinsuke Fujiwara, Journal of Bacteriology, 196, (10) 1866 - 1876, 05 , Refereed
  • Mechanistic studies on the binding of nitric oxide to a synthetic heme-thiolate complex relevant to cytochrome P450, Franke, Alicja; Stochel, Grazyna; Suzuki, Noriyuki; Higuchi, Tsunehiko; Okuzono, Kimiko; van Eldik, Rudi, J. Am. Chem. Soc., 127, (15) 5360 - 5375, 04 , Refereed
  • Nitrous Oxide Reduction-Coupled Alkene-Alkene Coupling Catalysed by Metalloporphyrin, Shunsuke Saito, Hiro Ohtake, Naoki Umezawa, Yuko Kobayashi, Nobuki Kato, Masaaki Hirobe, Tsunehiko Higuchi, Chemical Communications, 49, (79) 8979 - 8981, 10 , Refereed
  • Manganese Salen Complexes with Acid-Base Catalytic Auxiliary: Functional Mimetics of Catalase, Yukinobu Noritake, Naoki Umezawa, Nobuki Kato, Tsunehiko Higuchi, Inorganic Chemistry, 52, (7) 3653 - 3662, 04 , Refereed
  • Synthesis of the Carbon Framework of Scholarisine A by Intramolecular Oxidative Coupling, Tsugunori Watanabe, Nobuki Kato, Naoki Umezawa, Tsunehiko Higuchi, Chemistry - A European Journal , 19, (13) 4255 - 4261, 03 , Refereed
  • Effective Chiral Discrimination of Tetravalent Polyamines on Single-DNA Compaction, Yuko Yoshikawa, Naoki Umezawa, Yuki Imamura, Toshio Kanbe, Nobuki Kato, Kenichi Yoshikawa, Tadayuki Imanaka, Tsunehiko Higuchi, Angewandte Chemie International Edition, 52, (13) 3712 - 3716, 03 , Refereed
  • Effect of Helical Conformation and Side-Chain Structure on γ-Secretase Inhibition by β-Peptide Foldamers: Insight into Substrate Recognition, Yuki Imamura, Naoki Umezawa, Satoko Osawa, Naoaki Shimada, Takuya Higo, Satoshi Yokoshima, Tohru Fukuyama, Takeshi Iwatsubo, Nobuki Kato, Taisuke Tomita, Tsunehiko Higuchi, Journal of Medicinal Chemistry, 56, (4) 1443 - 1454, 02 , Refereed
  • Multiple Active Intermediates in Oxidation Reaction Catalyzed by Synthetic Heme-thiolate Complex Relevant to Cytochrome P450, Suzuki, Noriyuki; Higuchi, Tsunehiko; Nagano, Tetsuo, J. Am. Chem. Soc., 124, (32) 9622 - 9628, 08 , Refereed
  • Welcome to SRM2008, Higuchi Tsunehiko, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 128, Refereed
  • Effect of three-dimensionally fixed auxiliary to manganese Salen on its catalase-like activity and peroxidase-like activity, Noritake Yukinobu, Watanabe Yoritada, Namba Azusa, Kato Nobuki, Umezawa Naoki, Higuchi Tsunehiko, YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 128, Refereed
  • [Fluorescent detection of protein kinase activity: methodology to visualize "phosphate"]., Umezawa N, Higuchi T, Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 52, (13 Suppl) 1601 - 1607, 10 , Refereed
  • Efficient fluorescence assay for serine/threonine kinases, Umezawa Naoki, Akita Shoji, Higuchi Tsunehiko, DRUGS OF THE FUTURE, 32, 23 - 24, 07 , Refereed
  • Vibronic Coupling between Soret and Higher Energy Excited States in Iron(II) Porphyrins: Raman Excitation Profiles of A2g Modes in the Soret Region, Egawa, Tsuyoshi; Suzuki, Noriyuki; Dokoh, Takashi; Higuchi, Tsunehiko; Shimada, Hideo; Kitagawa, Teizo; Ishimura, Yuzuru, J. Phys. Chem. A, 108, (4) 568 - 577
  • Synthesis of New Bulky Tetraarylphosphonium, Tetraarylborate and Their Salt, Matsumoto, Kaya; Hatano, Keiichiro; Umezawa, Naoki; Higuchi, Tsunehiko, Synthesis, (13) 2181 - 2185
  • Catalytic and Asymmetric Epoxidation by Novel D4-Symmetric Chiral Porphyrin Derived from C2-Symmetric Diol, Nakagawa, Hiroshi; Sei, Yoshihisa; Yamaguchi, Kentaro; Nagano, Tetsuo; Higuchi, Tsunehiko, J. Mol. Cat. A:Chemical, 219, (2) 221 - 226
  • Electronic Effects on Enantioselectivity in the Epoxidation Catalyzed by D4-Symmetric Chiral Porphyrins, Nakagawa, Hiroshi; Sei, Yoshihisa; Yamaguchi, Kentaro; Nagano, Tetsuo; Higuchi, TsunehikoFrom Tetrahedron: Asymmetry (2004), 15(24), 3861-3867. | Language: English, Database: CAPLUS, Tetrahedron: Asym., 15, (24) 3861 - 3867
  • Reversible and competitive inhibition of enteropeptidase by 1-trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane (E-64), Matsushima, Masashi; Yahagi, Naohisa; Ichinose, Masao; Miki, Kazumasa; Omata, Masao; Higuchi, Tsunehiko; Inoue, Hideshi; Takahashi, Takayuki; Takahashi, Kenji, Biomed. Res., 22, (4) 207 - 210
  • Bioimaging of nitric oxide with fluorescent indicators based on the rhodamine chromophore, Kojima, Hirotatsu; Hirotani, Miki; Nakatsubo, Naoki; Kikuchi, Kazuya; Urano, Yasuteru; Higuchi, Tsunehiko; Hirata, Yasunobu; Nagano, Tetsuo, Anal. Chem., 73, (9) 1967 - 1973
  • Rational Design of Fluorescein-Based Fluorescence Probes. Mechanism-Based Design of a Maximum Fluorescence Probe for Singlet Oxygen, Tanaka, Kumi; Miura, Tetsuo; Umezawa, Naoki; Urano, Yasuteru; Kikuchi, Kazuya; Higuchi, Tsunehiko; Nagano, Tetsuo, J. Am. Chem. Soc., 123, (11) 2530 - 2536
  • Intramolecular Fluorescence Resonance Energy Transfer System with Coumarin Donor Included in β-Cyclodextrin, Takakusa, Hideo; Kikuchi, Kazuya; Urano, Yasuteru; Higuchi, Tsunehiko; Nagano, Tetsuo, Anal. Chem., 73, (5) 939 - 942
  • Selective Inhibition of Human Inducible Nitric Oxide Synthase by S-alkyl-L-isothiocitrulline-containing Dipeptides, Park, Jung-Min; Higuchi, Tsunehiko; Kikuchi, Kazuya; Urano, Yasuteru; Hori, Hiroyuki; Nishino, Takeshi; Aoki, Junken; Inoue, Keizo; Nagano, Tetsuo, Br. J. Pharamacol., 132, (8) 1876 - 1882
  • Synthesis of 5, 10, 15, 20-Tetrakis(4-┣DBtert(/)-┫DB-buty1-2, 6-dicarboxyphenyl)porphyrin : A Versatile Bis-Fased Porphyrin Synthon hof D, Nakagawa, Hiroshi; Nagano, Tetsuo; Higuchi, Tsunehiko, Org. Lett., 3, (12) 1805 - 1807
  • A new thioether-ligated iron porphyrin as a model of a protonated form of P450 active site, Dokoh T, Suzuki N, Higuchi T, Urano Y, Kikuchi K, Nagano T., J. Inorg. Biochem., 82, (1-4) 127 - 132
  • Design and synthesis of intramolecular resonance-energy transfer probes for use in ratiometric measurements in aqueous solution, Kawanishi, Yasutomo; Kikuchi, Kazuya; Takakusa,Hideo; Mizukami, Shin; Urano, Yasuteru;Higuchi, Tsunehiko; Nagano, Tetsuo, Angew. Chem. Int. Ed., 39, (19) 3438 - 3440
  • Fluorescence switching by O-dearylation of 7-aryloxycoumarins. Development of novel fluorescence probes to detect reactive oxygen species with high selectivity, Setsukinai, Ken-ichi; Urano, Yasuteru; Kikuchi, Kazuya; Higuchi, Tsunehiko; Nagano, Tetsuo, Perkin 2, (12) 2453 - 2457
  • Highly Zinc-Selective Fluorescent Sensor Molecules Suitable for Biological Applications, Hirano, Tomoya; Kikuchi, Kazuya; Urano, Yasuteru; Higuchi, Tsunehiko; Nagano, Tetsuo, J. Am. Chem. Soc., 122, (49) 12399 - 12400
  • Synthesis and superoxide dismutase activity of novel iron complexes, Tamura, Masakazu; Urano, Yasuteru; Kikuchi, Kazuya; Higuchi, Tsunehiko; Hirobe, Masaaki; Nagano, Tetsuo, J. Organomet. Chem., 611, (1-2) 586 - 592
  • Superoxide dismutase activity of iron(II)TPEN complex and its derivatives, Tamura, Masakazu; Urano, Yasuteru; Kikuchi, Kazuya; Higuchi, Tsunehiko; Hirobe, Masaaki;Nagano, Tetsuo, Chem. Pharm. Bull., 48, (10) 1514 - 1518
  • Development of a Time-Resolved Fluorometric Detection System Using Diffusion-Enhanced Energy Transfer, Koresawa, Mitsunori; Kikuchi, Kazuya; Mizukami, Shin; Kojima, Hirotatsu; Urano, Yasuteru; Higuchi, Tsunehiko; Nagano, Tetsuo, Anal. Chem., 72, (20) 4904 - 4907
  • Fluorescent indicators for nitric oxide based on rhodamine chromophore, Kojima, Hirotatsu; Hirotani, Miki; Urano, Yasuteru; Kikuchi, Kazuya; Higuchi, Tsunehiko; Nagano, Tetsuo, Tetrahedron Lett., 41, (1) 69 - 72
  • Novel Zinc Fluorescent Probes Excitable with Visible Light for Biological Applications, Hirano T, Kikuchi K, Urano Y, Higuchi T, Nagano T., Angew. Chem. Int. Ed., 39, (6) 1052 - 1054
  • Remarkable Axial Thiolate Ligand Effect on the Oxidation of Hydrocarbons by Active Intermediate of Iron Porphyrin and Cytochrome P450, Ohno T, Suzuki N, Dokoh T, Urano Y, Kikuchi K, Hirobe M, Higuchi T, Nagano T., J. Inorg. Biochem., 82, (1-4) 123 - 125
  • First Synthetic NO-heme-thiolate Complex Relevant to Nitric Oxide Synthase and Cytochrome P450nor, Suzuki, Noriyuki;Higuchi, Tsunehiko; Urano, Yasuteru; Kikuchi, Kazuya; Uchida, Takeshi; Mukai, Masahiro; Kitagawa, Teizo; Nagano, Tetsuo, J. Am. Chem. Soc., 122, (48) 12059 - 12060
  • Imaging of caspase-3 activation in HeLa cells stimulated with etoposide using a novel fluorescent probe, Mizukami, Shin; Kikuchi, Kazuya; Higuchi, Tsunehiko; Urano, Yasuteru; Mashima, Tetsuo; Tsuruo, Takashi; Nagano, Tetsuo, FEBS Lett., 453, (3) 356 - 360
  • Fluorescent Indicators for Imaging Nitric Oxide Production, Kojima, Hirotatsu; Urano, Yasuteru; Kikuchi, Kazuya; Higuchi, Tsunehiko; Hirata, Yasunobu; Nagano, Tetsuo, Angew. Chem. Int. Ed., 38, (21) 3209 - 3212
  • Novel Fluorscent Probes for Singlet Oxygen, Umezawa, Naoki; Tanaka, Kumi; Urano, Yasuteru; Kikuchi, Kazuya; Higuchi, Tsunehiko; Nagano, Tetsuo, Angew. Chem. Int. Ed., 38, (19) 2899 - 2901
  • Dipeptides Containing L-Arginine Analogs : New Isozyme-Selective Inhibitors of Nitric Oxide Synthase, Kobayashi, Nobutaka; Higuchi, Tsunehiko; Urano, Yasuteru; Kikuchi, Kazuya; Hirobe, Masaaki; Nagano, Tetsuo, Biol. Pharm. Bull., 22, (9)
  • Novel Iron Porphyrin-alkanethiolate Complex with Intramolecular NH…S Hydrogen Bond : Synthesis, Spectroscopy and Reactivity, Suzuki, Noriyuki; Higuchi, Tsunehiko; Urano, Yasuteru; Kikuchi, Kazuya; Uekusa, Hidehiro; Ohashi, Yuji; Uchida, Takeshi; Kitagawa, Teizo; Nagano, Tetsuo, J. Am. Chem. Soc., 121, (49) 11571 - 11572
  • Improved nitric oxide detection using 2,3-diaminonaphthalene and its application to the evaluation of novel nitric oxide synthase inhibitors, Nakatsubo, Naoki; Kojima, Hirotatsu; Sakurai, Kuniko; Kikuchi, Kazuya; Nagoshi, Hiroshi; Hirata, Yasunobu; Akaike, Takaaki; Maeda, Hiroshi; Urano, Yasuteru; Higuchi, Tsunehiko; Nagano, Tetsuo, Chem. Pharm. Bull., 21, (12) 1247 - 1250
  • Direct evidence of NO production in rat hippocampus and cortex using a new fluorescent indicator: DAF-2 DA, Kojima, Hirotatsu; Nakatsubo, Naoki; Kikuchi, Kazuya; Urano, Yasuteru; Higuchi, Tsunehiko; Tanaka, Junji; Kudo, Yoshihisa; Nagano, Tetsuo, NeuroReport, 9, (15) 3345 - 3348
  • Selective deoxygenation of heteroaromatic N-oxides with olefins catalyzed by ruthenium porphyrin, Nakagawa, Hiroshi; Higuchi, Tsunehiko; Kikuchi, Kazuya; Urano, Yasuteru; Nagano, Tetsuo, Chem. Pharm. Bull., 46, (10) 1656 - 1657
  • 酵素機能に対するポルフィリン配位構造の必然性, 樋口恒彦, 化学と生物, 36, (2)
  • Pronounced Axial Thiolate Ligand Effect on the Reactivity of High-Valent Oxo-Iron Porphyrin Intermediate, Urano, Yasuteru; Higuchi, Tsunehiko; Hirobe, Masaaki; Nagano, Tetsuo, J. Am. Chem. Soc., 119, (49)
  • Regio-and Stereo-selective Oxidation of Steroids Using 2,6-Dichloropyridine N-Oxide Catalysed by Ruthenium Porphyrins, Shigeaki, Tomoteru; Miura, Keiko; Higuchi, Tsunehiko; Hirobe, Masaaki; Nagano, Tetsuo, Chem. Commun., (9)
  • シトクロムP450における反応性とチオレート軸配位子との関わり:モデルからのアプローチ, 樋口恒彦, ポルフィリン, 6, (2)
  • 生体類似型酸化反応系[銅-アスコルビン酸-酸素]系-フェノール、アニソール類の選択的酸化とその反応機構および生理活性物質創製への応用, Aihara, Kazuhiro; Urano, Yasuteru; Higuchi, Tsunehiko; Hirobe, Masaaki, 有機合成化学協会誌, 55, (3) 196 - 206
  • Four Recent Studies in Cytochrome P450 Modelings : A Stable Iron Porphyrin Coordinated by a Thiolate Ligand ; A Robust Ruthenium Porphyrin-Pyridine N-Oxide derivatives System ; Polypeptide-bound Iron Porphyrin ; Application to Drug Metabolism Studies, Higuchi, Tsunehiko; Hirobe, Masaaki, J. Mol. Cat. A Chemical, 113
  • Substrate-dependentChanges of Oxidative Ο-Dealkylation Mechanism of Several Chemical and Biological Oxidizing System, Urano, Yasuteru; Higuchi, Tsunehiko; Hirobe, Masaaki, J. Chem.l Soc. Perkin 2, (6) 1169 - 1173
  • Application of chemical P-450 model systems to studies on drug metabolism. Part X. Novel hydroxylactonization of γ,δ- and β,γ-unsaturated carboxylic acids with an iron porphyrin-iodosylbenzenesystem, Komuro, Masakatsu; Higuchi, Tsunehiko; Hirobe, Masaaki, J. Chem. Soc. Perkin 1, (18) 2309 - 2313
  • Selective Quinone Formation by Aromatic Oxidation with Heteroaromatic N-Oxide Catalyzed by Ruthenium Porphyrin, Higuchi, Tsunehiko; Satake, Chika; Hirobe, Masaaki, J. Am. Chem. Soc., 117, 8879 - 8880
  • Application of Chemical Cytochrome P-450 Model Systems to Studies on Drug Metabolism-VIII. Novel Metabolism of Carboxylic Acids via Oxidative Decarboxylation, Komuro, Masakatsu; Higuchi, Tsunehiko; Hirobe, Masaaki, Bioorg. Med. Chem., 3, (1) 55 - 65
  • The Highly Efficient Oxidation of Olefins, Alcohols, Sulfides and Alkanes with Heteroaromatic N-oxides Catalyzed by Ruthenium Porphyrins, Ohtake, Hiro; Higuchi, Tsunehiko; Hirobe, Masaaki, Heterocycles, 40, (2) 867 - 903
  • シンクロムP450のO-O結合開裂機構をめぐる論争, 樋口恒彦, ファルマシア, 31
  • 含窒素芳香族複素環N-オキシドールテニウムポルフィリン触媒系による多様な高効率酸化反応, 樋口恒彦, 有機合成化学協会誌, 53, (7) 633 - 644
  • Identification of Novel Sugar, 4-Amino-4, 6-dideoxy-2-O-methylmannose in the lipopolysaccharide of Vibrio cholerae Ol Serotype Ogawa, Ito, Teruyo; Higuchi, Tsunehiko; Hirobe, Masaaki; Hiramatsu, Keiichi; Yokota, Takeshi, Carbohyd. Res., 256, 113 - 128
  • Mechanistic Studies of Selective Catechol Formation from o-Methoxyphenols Using A Copper(II)-Ascorbic Acid-Dioxygen System, Aihara, Kazuhiro; Urano, Yasuteru; Higuchi, Tsunehiko; Hirobe, Masaaki, J. Chem.l Soc. Perkin 2, (11) 2165 - 2170
  • Heterolytic O-O Bond Cleavage of Peroxy Acid and Effective Alkane Hydroxylation in Hydrophobic Solvent Mediated by an Iron Porphyrin Coordinated by Thiolate Anion as a Model for Cytochrome P-450, Higuchi, Tsunehiko; Shimada, Kousei; Maruyama, Naho; Hirobe, Masaaki, J. Am. Chem. Soc., 115, 7551 - 7552
  • Oxygen Activation by Iron(III) Porphyrin/NaBH4/Me4N. OH System as Cytochrome P-450 Model-Oxygenation of Olefin, N-Dealkylation of Tertiary Amine, Oxidation of Sulfide, and Oxidative Cleavage of Ether Bond, Mori, Takashi; Santa, Tomofumi;Higuchi, Tsunehiko; Mashino, Tadahiko; Hirobe, Masaaki, Chem. Pharm. Bull., 41, (2) 292 - 295
  • Unusual Substituent Effects on the hydroxylation of Phenols by Cu2+-Ascorbic Acid-O2 System, Gamma-Radiolysis, and Microsomes, Urnao, Yasuteru; Higuchi, Tsunehiko; Hirobe, Masaaki, Biochem Biophys Res Commun., 192, 568 - 574
  • Highly Efficient Oxidation of Alkanes and Alkyl Alcohols with Heteroaromatic N-Oxides Catalyzed by Ruthenium Porphyrins, Ohtake, Hiro; Higuchi, Tsunehiko; Hirobe, Masaaki, J. Am. Chem. Soc., 114, 10660 - 11661
  • The Selectivities and The Machanism on Highly Efficient Epoxidation of Olefins with 2, 6-Disubstituted Pyridine N-Oxides Catalyzed by Ruthenium Porphyrin, Ohtake, Hiro; Higuchi, Tsunehiko; Hirobe, Masaaki, Tetrahedron Lett., 33, 2521 - 2524
  • Oxidative Decarboxylation of Carboxylic Acids by Iron Porphyrin-Iodosylbenzene System, Komuro, Masakatsu; Higuchi, Tsunehiko; Hirobe, Masaaki, Tetrahedron Lett., 33, (34)
  • Comformation and Stereoselective Reduction of Hapten Side Chains in the Antibody Combining Site., Kim, Jae Il; Nagano, Tetsuo; Higuchi, Tsunehiko; Hirobe, Masaaki; Shimada, Ichio; Arata, Yoji, J. Am. Chem. Soc., 113, (24) 9392 - 9394
  • Highly Efficient Oxygen Transfer Reactionsfrom Various Heteroaromatic N-Oxides to Olefins, Alcohols, and Sulfides Catalyzed by Ruthenium Porphyrin., Higuchi, Tsunehiko; Ohtake, Hiro; Hirobe, Masaaki, Tetrahedron Lett., 32, (50) 7435 - 7438
  • 3-Hydroxycoumarins: first direct preparation from coumarins using a copper(2+)-ascorbic acid-oxygen system, and their potent bioactivities, Aihara, Kazuhiro; Higuchi, Tsunehiko; Hirobe, Masaaki, Biochem Biophys Res Commun., 168, (1) 169 - 175
  • Application of chemical P-450model systems to study drug metabolism. III. Metabolism of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, Nagatsu, Yoshio; Higuchi, Tsunehiko; Hirobe, Masaaki, Chem. Pharm. Bull., 38, (2) 400 - 403
  • Synthesis of a highly stable iron porphyrin coordinated by alkylthiolate anion as a model for cytochrome P-450 and its catalytic activity in oxygen-oxygen bond cleavage, Higuchi, Tsunehiko; Uzu, Shinobu; Hirobe, Masaaki, J. Am. Chem. Soc., 112, (19) 7051 - 7053
  • Increasing 5-Lipoxygenase Inhibitory Activities by Oxidative Conversion of o-Methoxyphenols to Catechols Using Cu, Aihara, Kazuhiro; Higuchi, Tsunehiko; Hirobe, Masaaki, Chem. Pharm. Bull., 38, (3)
  • Highly efficient epoxidation of olefins with pyridine N-oxides catalyzed by ruthenium porphyrins, Higuchi, Tsunehiko; Ohtake, Hiro; Hirobe, Masaaki, Tetrahedron Lett., 30, (47) 6545 - 6547
  • Identification and Quantification of p-Hydroxyethylamphetamine as a Novel Metabolite of Ethylamphetamine in Rat by Gas Chromato-graphy-Mass Spectrometry, Makino, Yukiko; Higuchi, Tsunehiko; Ohta, Shigeru; Hirobe, Masaaki, Forensic Science International, 41
  • Facile Preparation of Unstable Metabolic Intermediates : Epoxide(s) of Pyrazolo[1,5-a]pyridine Derivatives by Cytochrome P-450 Chemical Model, Nagatsu, Yoshio; Higuchi, Tsunehiko; Hirobe, Masaaki, Chem. Pharm. Bull., 37
  • Versatile chiral synthons for vic-amino alcohols. Facile synthesis of (2S,3R)-3-hydroxyglutamic acid and (+)-statine, Kunieda, Takehisa; Ishizuka, Tadao; Higuchi, Tsunehiko; Hirobe, Masaaki, J. Org. Chem., 53, (14) 3381 - 3383
  • Highly Efficient Oxazolone-derived Reagents for β-Lactam Formation from β-Amino Acids, Kunieda, Takehisa; Nagamatsu, Tomohisa; Higuchi, Tsunehiko; Hirobe, Masaaki, Tetrahedron Lett., 29, (18)
  • Oxygen-copper(2+)-ascorbic acid: a novel oxidation system for the highly selective O-dealkylation of 2-alkoxyphenols, Aihara, Kazuhiro; Higuchi, Tsunehiko; Hirobe, Masaaki, Chem. Pharm. Bull., 36
  • 3-Acyl-2-Oxazolone-zirconium Complex As Excellent Reagents for Highly Regioselective Acylation of Polyalcohols, Kunieda, Takehisa; Mori, Takashi; Higuchi, Tsunehiko; Hirobe, Masaaki, Tetrahedron Lett., 26, (16)
  • 3-Alkoxycarbonyl-2-oxazolones and Their Homopolymers as Highly Preservable Amino-protecting Reagents. tert-Butoxycarbonylation of Amino Groups., Kunieda, Takehisa; Higuchi, Tsunehiko; Abe, Yoshihiro; Hirobe, Masaaki, Chem. Pharm. Bull., 32, (6) 2174 - 2181
  • Activation of carboxyl groups by diphenyl 2-oxo-3-oxazolinylphosphonate. Facile preparation of versatile reagents, 3-acyl-2-oxazolones, Kunieda, Takehisa; Higuchi, Tsunehiko; Abe, Yoshihiro; Hirobe, Masaaki, Tetrahedron, 39, (20) 3253 - 3260
  • Highly selective acylation of amines and alcohols by poly(3-acyl-2-oxazolone), Kunieda, Takehisa; Higuchi, Tsunehiko; Abe, Yoshihiro; Hirobe, Masaaki, Tetrahedron Lett., 23, (11) 1159 - 1160
  • A new reagent for activating carboxyl groups: diphenyl 2-oxo-3-oxazolinylphosphonate, Kunieda, Takehisa; Abe, Yoshihiro; Higuchi, Tsunehiko; Hirobe, Masaaki, Tetrahedron Lett., 22, (13) 1257 - 1258
  • 3-Acyl- and 3-alkoxycarbonyl-2-oxazolones and their homopolymers as amino-protecting reagents, Kunieda, Takehisa; Higuchi, Tsunehiko; Abe, Yoshihiro; Hirobe, Masaaki, Tetrahedron Lett., 21, (32) 3065 - 3066
  • Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues, Naoki Umezawa, Kasumi Tsuji, Shin Sato, Masaki Kikuchi, Hisami Watanabe, Yuhei Horai, Masashi Yamaguchi, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi, RSC Advances, 8, 36895 - 36902, Refereed
  • Polyoxygenated seco -cyclohexenes and other constituents from Uvaria valderramensis, Allan Patrick G. Macabeo, Peter Yuosef M. Rubio, Tsunehiko Higuchi, Naoki Umezawa, Christian Faderl, Simon Budde, Porferio S. Bangcaya, Grecebio Jonathan D. Alejandro, Biochemical Systematics and Ecology, 71, 200 - 204, Refereed
  • Efficient oxidation of ethers with pyridine N-oxide catalyzed by ruthenium porphyrins, Nobuki Kato, Yu Hamaguchi, Naoki Umezawa and Tsunehiko Higuchi, Journal of of Porphyrins and Phthalocyanines, 27, (1~3) 411 - 416, Refereed

Books etc

  • Polypeptide-bound Porphinatoirons as Cytochrome P-450 Model Compound.,   1988
  • Pronounced Effects of Axial Thiolate Ligand on Oxygen Activation by Iron Porphyrin,   1998
  • Rational Design of Fulorescein-based Fluorescence Probes.-Mechanism-based Design of a Maximum Fluorescence Probe for Singlet Oxygen-,   2001
  • 薬学のための無機化学, 化学同人,   2005 , ISBN:978-4-7598-0988-6, 共著
  • 無機化学, 化学同人,   2011 , ISBN:978-4-7598-1254-1, 共著

Conference Activities & Talks

  • 「分子バーコード」としての合成DNAによる個別情報付加, 日本薬学会第128年会,   2008
  • 一般性の高いケージドペプチド設計法, 日本薬学会第128年会,   2008
  • Turn-on Fluorescent Probes for Recognition of Specific Peptide Sequence, The 21st Century COE-RCMS International Conference on Elucidation and Creation of Molecular Functions,   2007
  • Efficient Isomerization of Endoperoxide Catalyzed by Heme-thiolate Complex, The 21st Century COE-RCMS International Conference on Elucidation and Creation of Molecular Functions,   2007
  • ヘムと強い相互作用を行う分子の設計とその抗マラリア活性, 日本薬学会第127年会,   2007
  • シトクロムP450化学モデルによるプロスタグランジンH2の異性化反応, 日本薬学会第127年会,   2007
  • セリン・トレオニンキナーゼの効率的蛍光検出法の開発, 日本薬学会第127年会,   2007
  • 光駆動回転分子の創製, 日本薬学会第127年会,   2007
  • 膜電位の定量計測を目指したフォトクロミック分子の開発, 日本薬学会第127年会,   2007
  • ヘム-チオレート錯体によるプロスタグランジンH2の効率的異性化反応, 第17回金属の関与する生体関連反応シンポジウム ,   2007
  • 一般性の高いケージドペプチド設計法, 第53回日本薬学会東海支部総会・大会,   2007
  • HTSを目指したセリン・トレオニンキナーゼ蛍光アッセイ法の開発, 日本分析化学会第56年会,   2007
  • 水素結合に基づく基質認識能を有するポルフィリン金属錯体による位置選択的, 第100回触媒討論会,   2007
  • マンガンサレン錯体のカタラーゼ様活性に及ぼす分子内反応補助基の協奏的効果, 第57回錯体化学討論会,   2007
  • ヘム-チオレート錯体によるプロスタグランジンH2の触媒的異性化反応, 第22回生体機能関連化学シンポジウム ,   2007
  • 一般性の高いケージドペプチド設計法, 第22回生体機能関連化学シンポジウム ,   2007
  • 合成DNAを用いた塗料への個別情報付加, 第22回生体機能関連化学シンポジウム ,   2007
  • 環構造を有する新規ポリアミン類の合成と活性評価, 第22回生体機能関連化学シンポジウム ,   2007
  • Development of On-chip Fluorescence Assay for Serine/threonine Kinases, 4th International Peptide Symposium,   2007
  • Efficient Isomerization of Prostaglandin H2 Catalyzed by Heme-Thiolate Complexes, The 67th Okazaki Conference Molecular Science and Chemical Biology of Biomolecular Function,,   2007
  • 反応補助基を導入したマンガンサレン錯体の活性酸素消去活性, 第40回酸化反応討論会,   2007
  • マンガンサレン錯体への反応補助基導入による活性酸素消去能の高効率化, 第26回メディシナルケミストリーシンポジウム,   2007
  • Turn-on Fluorescent Probes Targeted to a Hexahistidine Tag Peptide, The 4th Takeda Science Foundation Symposium on PharmaSciences,   2007
  • 環構造を有する新規ポリアミンの合成と活性評価, 平成19年度日本薬学会東海支部例会,   2007
  • 化学進化的合成化学によるβ-アミロイド親和性物質の開発, 平成19年度日本薬学会東海支部例会,   2007
  • 「分子バーコード」としての合成DNAによる個別情報付加, 平成19年度日本薬学会東海支部例会,   2007
  • ヘム-チオレート錯体によるプロスタグランジンH2の触媒的異性化反応, 平成19年度日本薬学会東海支部例会,   2007
  • 三次元的に固定した分子内反応補助基のマンガンサレン錯体の酵素類似触媒活性に及ぼす効果, 特定領域研究「協奏機能触媒」第3回公開シンポジウム,   2007
  • Staudinger Ligationを用いたPeptide-Porphyrin Conjugateの汎用的合成法の開発, 第8回生命化学研究会シンポジウム,   2006
  • 任意配列が可能な合成DNAを情報素子として用いた塗装等の個別認証新技術, 日本薬学会第126年会,   2006
  • ヘムの触媒するプロスタグランジン異性化酵素モデル反応における顕著な軸配位子効果, 日本薬学会第126年会,   2006
  • ヒスタグペプチドの添加により蛍光強度が増大する新規蛍光プローブの開発, 日本薬学会第126年会,   2006
  • グアニジノ基をピリジン環に構造変換したアルギニン類似型NOS阻害剤の開発, 日本薬学会第126年会,   2006
  • 環構造を有する新規ポリアミン類縁体の合成と機能評価, 日本薬学会第126年会,   2006
  • ヘムへのスタッキング能と鉄への配位能を兼ね備えた分子の合成と抗マラリア活性, 日本薬学会第126年会,   2006
  • セリン・スレオニンキナーゼ活性のオンビーズ蛍光検出法の開発, 日本ケミカルバイオロジー研究会第1回年会,   2006
  • Novel fluorescent probes for recognition of specific peptide sequence, 第16回金属の関与する生体関連反応シンポジウム,   2006
  • Endoperoxide isomerization catalyzed by a heme-thiolate complex relevant to prostaglandin H2 isomerases, 第16回金属の関与する生体関連反応シンポジウム,   2006
  • ヘムチオレート錯体の触媒するエンドペルオキシドの高速異性化反応-プロスタグランジン異性化酵素との関連-, 第52回日本薬学会東海支部総会・大会,   2006
  • ヘムチオレート錯体の触媒するエンドペルオキシドの高速異性化反応-プロスタグランジンH2異性化酵素との関連-, 第18回生体機能関連化学若手の会サマースクール,   2006
  • 特定ペプチド配列の認識を目指した蛍光試薬の開発, 第18回生体機能関連化学若手の会サマースクール,   2006
  • 合成DNAを用いた塗料への個別情報付加, 第18回生体機能関連化学若手の会サマースクール,   2006
  • 環構造を有する新規ポリアミン類の合成と活性評価, 第18回生体機能関連化学若手の会サマースクール,   2006
  • 基質認識能を有するルテニウムポルフィリン錯体によるアルキル鎖の位置選択的触媒酸化, バイオ関連化学合同シンポジウム,   2006
  • 特定ペプチド配列を認識し発蛍光する蛍光試薬の開発, バイオ関連化学合同シンポジウム,   2006
  • セリン・トレオニンキナーゼの効率的蛍光検出法の開発, バイオ関連化学合同シンポジウム,   2006
  • ヘムと強い相互作用を行う分子の設計とその抗マラリア活性, バイオ関連化学合同シンポジウム,   2006
  • Efficient Fluorescence Assay for Serine/Threonine Kinases, International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting (43JPS-PEM4),   2006
  • Chemoselective Synthesis of Peptide-Porphyrin Conjugate, International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering,   2006
  • Novel Fluorescent Probes for Recognition of Specific Peptide Sequence, International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering,   2006
  • ヘムチオレート錯体の触媒するエンドペルオキシドの高速異性化反応-プロスタグランジン異性化酵素との関連-, 第39回酸化反応討論会,   2006
  • 水素結合に基づく基質認識能を有するポルフィリン金属錯体の合成と位置選択的アルキル鎖酸化, 第39回酸化反応討論会,   2006
  • ヘムチオレート錯体の触媒するエンドペルオキシドの高速異性化反応-プロスタグランジン異性化酵素との関連-, 名古屋大学21世紀COEプログラム「物質科学の拠点形成:分子機能の解明と創造」,   2006
  • 環構造を有する新規ポリアミン類の合成とその活性評価, 名古屋大学21世紀COEプログラム「物質科学の拠点形成:分子機能の解明と創造」,   2006
  • 特定ペプチド配列を認識し発蛍光する蛍光試薬の開発, 名古屋大学21世紀COEプログラム「物質科学の拠点形成:分子機能の解明と創造」,   2006
  • ケトイミンの触媒的不斉Strecker反応の開発, 名古屋大学21世紀COEプログラム「物質科学の拠点形成:分子機能の解明と創造」第3回有機化学若手研究会,   2006
  • ヒスタグ配列を認識し発蛍光する蛍光試薬の開発, 平成18年度日本薬学会東海支部例会,   2006
  • セリン・スレオニンキナーゼ活性の蛍光検出法の開発, 第7回生命化学研究会シンポジウム,   2005
  • 疎水性官能基導入によるアルギニンアナログのNO合成酵素阻害選択性への効果, 日本薬学会第125年会,   2005
  • 基質認識能を有するポルフィリン金属錯体の合成と位置選択的アルカン酸化, 日本薬学会第125年会,   2005
  • チオレート配位ヘムによるアルキルヒドロペルオキシドのO-O結合開裂反応解析, 日本薬学会第125年会,   2005
  • セリン・スレオニンキナーゼ活性のオンビーズ蛍光検出法の開発, 日本薬学会第125年会,   2005
  • 化学平衡を利用した熱力学的最適化による化学合成, 日本薬学会第125年会,   2005
  • 汎用性の高いペプチドーポルフィリン複合体合成法の開発, 日本薬学会第125年会,   2005
  • 抗マラリア薬を目指した高いヘム親和性を有する分子の開発, 日本薬学会第125年会,   2005
  • 反応補助基を導入したシクロペンタン環を骨格に有するマンガンサレン錯体類の合成と活性酸素消去能, 日本薬学会第125年会,   2005
  • シトクロムP450配位構造の特性解明及び強力な酸化反応系の開発, 明治薬科大学,   2005
  • 疎水性官能基導入によるアルギニンアナログのNO合成酵素阻害選択性への効果, 第51回日本薬学会東海支部総会・大会,   2005
  • 化学平衡を利用した標的分子に対する低分子受容体のテーラーメード合成, 第51回日本薬学会東海支部総会・大会,   2005
  • Role of Axial Thiolate Ligand in Cytochrome P450 Catalysis: Chemical Model Approach, US-Japan Conference on Drug Development&Rational Drug Therapy 2005,   2005
  • 反応補助基を導入したシクロペンタン環を骨格に有するマンガンサレン錯体類の合成と活性酸素消去能, 第20回生体機能関連化学シンポジウム,   2005
  • ヘムの触媒するプロスタグランジン合成酵素モデル反応における顕著な軸配位子効果, 第20回生体機能関連化学シンポジウム,   2005
  • 化学平衡を利用した標的分子に対する低分子受容体のテーラーメード合成, 第20回生体機能関連化学シンポジウム,   2005
  • ヘムを標的とする新規抗マラリア薬の合成と活性評価, 第24回メディシナルケミストリーシンポジウム,   2005
  • 化学平衡を利用した標的分子に対する低分子受容体のテーラーメード合成, 第24回メディシナルケミストリーシンポジウム,   2005
  • Versatile Synthesis of Peptide-Porphyrin Conjugate, International Chemical Congress of Pacific Basin Societies (PACIFICHEM2005),   2005
  • On-bead Fluorescence Assay for Serine/Threonine Kinases, International Chemical Congress of Pacific Basin Societies (PACIFICHEM2005),   2005
  • Structural-functional Models of Cytochrome P450 and Catalase, International Chemical Congress of Pacific Basin Societies (PACIFICHEM2005),   2005
  • ルマジン誘導体の蛍光性金属センサー機能とその機構解明, 日本薬学会第124年会,   2004
  • ルテニウムポルフィリン-ピリジンN-オキシド系によるN-アシル環状アミン類の酸化的開裂反応, 日本薬学会第124年会,   2004
  • シトクロムP450活性種特定を指向した中間体保護型ヘム-チオレート分子の開発, 日本薬学会第124年会,   2004
  • 嵩高い有機塩による分極効果:電場形成酵素機能モデル, 日本薬学会第124年会,   2004
  • P450の多様性を支える反応機構, 日本薬学会第124年会,   2004
  • アシルウレア構造を組み込んだ新規クラウンエーテル類の合成法開発とカルシウムイオン選択的蛍光プローブ構築への応用, 第14回金属の関与する生体関連反応シンポジウム ,   2004
  • Staudinger Ligationを用いた汎用性の高いペプチド-ポルフィリン複合体合成法の開発, 第2回次世代を担う有機化学シンポジウム,   2004
  • シトクロムP450酵素機能における中心錯体構造の必然性, 京都薬科大学,   2004
  • シクロペンタン環を骨格に導入したマンガンサレン錯体類の合成と活性酸素消去能, 第50回日本薬学会東海支部大会,   2004
  • Staudinger Ligationを用いた汎用性の高いペプチド-ポルフィリン複合体合成法の開発, 第50回日本薬学会東海支部大会,   2004
  • 抗マラリア薬を目指した高いヘム親和性を有する分子の開発, 第50回日本薬学会東海支部大会,   2004
  • セリン・スレオニンキナーゼ活性のオンビーズ蛍光検出法の開発, 第19回生体機能関連化学シンポジウム若手フォーラム,   2004
  • チオレート配位ヘムによるアルキルヒドロペルオキシドのO-O 結合開裂反応解析, 第19回生体機能関連化学シンポジウム,   2004
  • セリン・スレオニンキナーゼ活性のオンビーズ蛍光検出法の開発, 第19回生体機能関連化学シンポジウム,   2004
  • スタウディンガー反応を用いた汎用性の高いペプチド?ポルフィリン複合体合成法の開発, 第19回生体機能関連化学シンポジウム,   2004
  • ルテニウムポルフィリンの触媒するN-アシル環状アミン類のN-アシルアミノ酸への直接変換, 第19回生体機能関連化学シンポジウム,   2004
  • 基質認識能を有するポルフィリン金属錯体の合成と位置選択的アルカン酸化, 第30回反応と合成の進歩シンポジウム,   2004
  • ルテニウムポルフィリンの触媒するN-アシル環状アミン類のN-アシルアミノ酸への酸化的直接変換反応, 第30回反応と合成の進歩シンポジウム,   2004
  • シクロペンタン環を骨格に導入したマンガンサレン錯体類の合成と活性酸素消去能, 第37回酸化反応討論会,   2004
  • ヘム酵素に関連した特徴的機能性分子の開発, 日本大学薬学部,   2004
  • セリン・スレオニンキナーゼ活性のオンビーズ蛍光検出法の開発, 平成16年度日本薬学会東海支部例会,   2004
  • Active Intermediates in Oxidation Reaction Catalyzed by Synthetic Heme-Thiolate Complex Relevant to Cytochrome P450, 3rd International Conference on Porphyrins and Phthalocyanins

Patents

  • 情報化核酸及びこれを用いた情報化核酸組成物, 特願2004-286704
  • 情報化核酸担持微粒子及びその製造方法, 特願2004-286555
  • 製品製造方法, 特願2004-286558
  • キナーゼ活性検出法, 特願2004-293084
  • 下塗り塗料組成物及び下塗り塗膜, 特願2004-362120
  • 着色上塗り塗料組成物及び上塗り塗膜, 特願2004-362121
  • クリヤー塗料組成物及びクリヤー塗膜, 特願2004-362123
  • 艶消し塗料組成物及び艶消し塗膜, 特願2004-362125
  • 非露出面用塗料組成物及び非露出面塗膜, 特願2004-362130
  • 補修塗膜及び補修塗装方法, 特願2004-362136

Awards & Honors

  •   2003 03 , The Pharmaceutical Society of Japan, The PSJ Award for Divisional Scientific Promotion

Research Grants & Projects

  • カテナン・ロタキサン構造の導入による生理活性分子の活性制御新手法,   2011  - 2012
  • 化学進化的合成化学による医薬機能分子の汎用性ある効率的創製,   2008  - 2011
  • 分子内反応補助基の協奏的効果による酵素類似触媒の高度機能化,   2008  - 2009
  • 新概念に基づく高い効率を目指した光駆動一方向回転分子の開発,   2007  - 2008
  • 官能基集積による協同効果を利用した医薬機能分子の動的創製,   2006  - 2007
  • 極微量で個別認証を可能にする人工DNA結合微粒子情報素子の開発,   2005  - 2006
  • 医薬開発及び環境浄化への応用に有効な強力酸化触媒反応系の開発,   2000  - 2002
  • ポルフィリン配位構造の特性探求と医薬化学への応用,   1999  - 2001
  • 強力な酸化反応性を有する強靱なRuポルフィリン担持高分子触媒の開発
  • 硫黄配位子への水素結合形式の与える金属-硫黄錯体の電子伝達能への効果
  • 分子内反応補助基の協奏的効果による酵素類似触媒の高度機能化

Social Contribution Activities Information

Social Contribution

  • 独立行政法人日本学術振興会科学研究費委員会審査委員, 行政,   2012 12 10  - 2013 11 30 , 独立行政法人日本学術振興会科学研究費の申請に関する審査を行った。
  • 第45回酸化反応討論会の開催, 地域団体・NPO,   2012 04 01  - 2012 12 15 , 第45回酸化反応討論会を、名古屋市立大学病院大ホールで平成24年11月16日−17日に開催した。(実行委員長:樋口恒彦)


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