Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2015/04 -2018/03
Author : Shibuya Yasuyuki
Currently, there are no drugs effective for treating oral leukoplakia, which is an oral precancerous lesion. Accordingly, we have screened the oral leukoplakia preventive active compounds of dietary origin in the present study. To find out the active compounds, we have established a monitoring system which can serve to facilitate the discovery of novel compounds from natural resources that inhibit mRNA processing. AS a result, we found that the isoflavone fraction extracted from soybean possessed mRNA processing inhibitory activity. Moreover, we found that Apigenin, Luteolin and Chrysin which were flavonoids have the strong mRNA maturation inhibitory activity. Using a rat model of tongue precancerous lesion with 4-nitroquinoline 1-oxide (4NQO), it has been also demonstrated that apigenin improved the precancerous lesion.