Researcher Database


Freeword

TSUIJI Hitomi

FacultyGraduate School of Pharmaceutical Sciences Department of Biomedical Science
PositionLecturer
Mail
HomepageURL
Birthday
Last Updated :2020/07/04

Researcher Profile and Settings

Education

  •   1994 04  - 1999 03 , The University of Tokyo, Graduate School of Pharmaceutical Sciences
  •   1990 04  - 1994 03 , The University of Tokyo, Faculty of Pharmaceutical Sciences

Degree

  • Ph.D, University of Tokyo

Academic & Professional Experience

  •   2014  - 現在, Nagoya City University, Graduate School of Pharmaceutical Sciences
  •   2014  - 2015 , Nagoya University

Research Activities

Research Areas

  • Life sciences, Molecular biology
  • Life sciences, Neuroscience - general

Published Papers

  • A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates Reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum., Yamakage Y, Kato M, Hongo A, Ogino H, Ishii K, Ishizuka T, Kamei T, Tsuiji H, Miyamoto T, Oishi H, Kohno T, Hattori M, Molecular and cellular neurosciences, 100, 09 , Refereed
  • Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway., Nishino K, Watanabe S, Shijie J, Murata Y, Oiwa K, Komine O, Endo F, Tsuiji H, Abe M, Sakimura K, Mishra A, Yamanaka K, Acta Neuropathol Commun., 7, (1) , 07 , Refereed
  • Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse., Yamakage Y, Tsuiji H, Kohno T, Ogino H, Saito T, Saido TC, Hattori M, Biological & pharmaceutical bulletin, 42, (3) 354 - 356, Refereed
  • Establishment of In Vitro FUS-Associated Familial Amyotrophic Lateral Sclerosis Model Using Human Induced Pluripotent Stem Cells., Naoki Ichiyanagi, Koki Fujimori, Masato Yano, Chikako Ishihara-Fujisaki, Takefumi Sone, Tetsuya Akiyama, Yohei Okada, Wado Akamatsu, Takuya Matsumoto, Mitsuru Ishikawa, Yoshinori Nishimoto, Yasuharu Ishihara, Tetsushi Sakuma, Takashi Yamamoto, Hitomi Tsuiji, Naoki Suzuki, Hitoshi Warita, Masashi Aoki, Hideyuki Okano, Stem cell reports, 6, (4) 496 - 510, 04 12 , Refereed, Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disorder. Although its neuropathology is well understood, the cellular and molecular mechanisms are yet to be elucidated due to limitations in the currently available human genetic data. In this study, we generated induced pluripotent stem cells (iPSC) from two familial ALS (FALS) patients with a missense mutation in the fused-in sarcoma (FUS) gene carrying the heterozygous FUS H517D mutation, and isogenic iPSCs with the homozygous FUS H517D mutation by genome editing technology. These cell-derived motor neurons mimicked several neurodegenerative phenotypes including mis-localization of FUS into cytosolic and stress granules under stress conditions, and cellular vulnerability. Moreover, exon array analysis using motor neuron precursor cells (MPCs) combined with CLIP-seq datasets revealed aberrant gene expression and/or splicing pattern in FALS MPCs. These results suggest that iPSC-derived motor neurons are a useful tool for analyzing the pathogenesis of human motor neuron disorders.


Copyright (c) MEDIA FUSION Co.,Ltd. All rights reserved.