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ITO Yuki

    Graduate School of Medical Sciences Department of Occupational and Environmental Health　Associate Professor
Last Updated :2024/03/19

Researcher Information

URL

J-Global ID

Research Interests

  • Hygiene   Environmental chemicals   Risk assessment   Environmental health   Human biomonitoring   Toxicology   Environmental epidemiology   Biological monitoring   

Research Areas

  • Life sciences / Hygiene and public health (non-laboratory)
  • Life sciences / Hygiene and public health (laboratory)
  • Environmental science/Agricultural science / Environmental effects of chemicals
  • Environmental science/Agricultural science / Environmental effects of radiation
  • Environmental science/Agricultural science / Environmental impact assessment

Academic & Professional Experience

  • 2019/10 - Today  Nagoya City UniversityGraduate School of Medical Sciences, Department of Occupational and Environmental HealthAssociate Professor
  • 2013/06 - 2019/09  Nagoya City UniversityGraduate School of Medical Sciences, Department of Occupational and Environmental Health(full-time) lecturer
  • 2009/06 - 2013/05  Nagoya City UniversityGraduate School of Medical Sciences, Department of Occupational and Environmental HealthAssistant professor
  • 2007/11 - 2009/05  Nagoya UniversityGender equality officeDesignated assistant professor
  • 2007/04 - 2007/11  Nagoya University Graduate School of MedicineOccupational and Environmental HealthDesignated assistant professor

Association Memberships

  • THE JAPANESE SOCIETY FOR HYGIENE   JAPAN SOCIETY FOR OCCUPATIONAL HEALTH   International Epidemiological Association   JAPAN EPIDEMIOLOGICAL ASSOCIATION   THE JAPANESE SOCIETY OF TOXICOLOGY   Japanese Society of Toxicologic Pathology   Japan Society of Endocrine Disrupters Research   Tokai Public Health Association, Japan   Japanese Society of Public Health   

Published Papers

MISC

Awards & Honors

  • 2023/11 Nagoya City University FY2023 Chancellor's Award, Research field B
     
    受賞者: Yuki ITO
  • 2021/05 Japan Society for Occupational Health, Occupational Hygiene and Ergonomics Encouragement Award
     
    受賞者: 伊藤由起
  • 2021/05 Japan Society for Occupational Health Distinguished reviewer award
     
    受賞者: 伊藤由起
  • 2020/10 Nagoya City University FY2020 President award
     
    受賞者: Yuki Ito
  • 2018/03 Japanese Society for Hygiene prize for encouragement
     
    受賞者: Yuki Ito
  • 2015 Japanese Society for Hygiene Best paper award FY2014
     
    受賞者: 伊藤 由起
  • 2014 The 84th Annual Meeting of the Japanese Society for Hygiene Presentation Award for young researchers
     
    受賞者: Yuki Ito
  • 2013 第83回日本衛生学会学術総会 Presentation Award for young researchers (The 83rd Annual Meeting of the Japanese Society for Hygiene)
     
    受賞者: 伊藤由起
  • 2009 第79回日本衛生学会学術総会 Presentation Award for young researchers (The 79th Annual Meeting of the Japanese Society for Hygiene)
     
    受賞者: 伊藤由起
  • 2008 第78回日本衛生学会学術総会 Presentation Award for young researchers (The 78th Annual Meeting of the Japanese Society for Hygiene)
     
    受賞者: 伊藤由起

Research Grants & Projects

  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2022/04 -2025/03 
    Author : 伊藤 由起
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2021/07 -2023/03 
    Author : 伊藤 由起
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2019/06 -2022/03 
    Author : Ito Yuki
     
    Non-regulated compound 2-ethyl-1-hexanol (2EH) of which indoor concentrations are sometimes relatively high has been reported to be associated with sick building syndrome (SBS). A few SBS patients complain of skin symptoms as well as nasal, ocular, and throat symptoms. We examined whether or not 2EH chronic exposure causes skin damage. Inhalation exposure to 2EH increased erythematous area, hair loss, dermal sclerosis, and epidermal thickness in the dorsal area after 21-week exposure to 2EH, however, these changes are independent of dermal changes.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2019/04 -2022/03 
    Author : Ito Yuki
     
    Organophosphorus (OP) insecticides inhibit acetylcholine esterase (AchE) by phosphorylation and exert neurotoxic effects in insects. Recently, it has been reported that OP insecticides also affect the serine residue in other enzymes. The objective of this study is to clarify whether OP insecticides induce neurodevelopmental adverse effects in humans. In the prospective cohort study, we conducted questionnaire surveys on children’s neurodevelopment at 7.5 and 8 years of age and the responses were approximately 2600. In a crude analysis, no relationship between OP insecticide exposure levels in toddlers and neurodevelopmental outcomes at the same point was shown. We will reanalyze the association by adjusting for some potential confounders.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2016/04 -2019/03 
    Author : Ito Yuki; TOMIZAWA Motohiro
     
    The results will be published later.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2016/04 -2018/03 
    Author : Miyake Mio; KAMIJIMA Michihiro; SAKAMOTO Tatsuo; ITO Yuki; SAWAMOTO Kazunobu; SAWADA Masato; OYA Naoko; WAKAYAMA Takanari; SATO Hirotaka
     
    Details of the results will be described later.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2013/04 -2016/03 
    Author : Ito Yuki; NAKAJIMA Tamie
     
    Di(2-ethylhexyl)phthalate (DEHP) is a major plasticizer for polyvinyl chloride products and used widely. On the other hand, carcinogenicity of DEHP has been drawn attentions for the last two decades. Functional species differences exist in the nuclear receptor to which metabolites of DEHP bind, therefore the hepatocarcinogenic response is thought to be not relevant to humans. Our experiments showed that DEHP induced hepatic tumors in humanized transgenic mice but the mode of action may differ from that in wild-typed mice.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2013/04 -2016/03 
    Author : KAMIJIMA Michihiro; ITO Yuki; UEYAMA Jun; NAKAI Kunihiko; EBARA Takeshi; KATO Sayaka; OGURI Tomoko; HIROTAKA Sato
     
    In recent years, health risks due to exposure to low-level chemicals have drawn global attention. This project, focusing on insecticides, aimed to build a birth cohort in which their urinary exposure biomarkers could be measured and to estimate their levels during pregnancy. In addition, cross-sectional surveys were conducted in different populations to clarify the biomarker levels in 3-year-old children and if the individual difference in their metabolism could affect their urinary concentrations.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2012/04 -2016/03 
    Author : Kamijima Michihiro; NASU Tamie; NAITO Hisao; YAMANOSHITA Osamu; ITO Yuki; Wang Hailan; Huang Hanlin
     
    Trichloroethylene is a solvent used worldwide to degrease industrial products such as metal parts and circuit boards. Generalized hypersensitivity dermatitis accompanying hepatitis, which is internationally called as occupational trichloroethylene hypersensitivity syndrome, has occurred in China since late 1990’s. This project aimed at clarifying risk factors for occurring and developing this disease. Exposure dose, individual susceptible factors, and biomarkers for reactivation of latent human herpesvirus 6 were investigated. Finally, an occupational exposure standard to prevent this disease was proposed.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2012/04 -2015/03 
    Author : MIYAKE Mio; SAKAMOTO Tatsuo; KAMIJIMA Michihiro; ITO Yuki
     
    2-ethyl-1-hexanol (2E1H) is reported to be one of the causative VOCs of sick building syndrome(SBS) and be associated with increased sense of smell. The goal of this investigation is to clarify histopathological changes due to subchronic inhalation exposure to 2E1H on the olfactory system, especially olfactory epithelium (OE) of the nasal cavity and the olfactory bulb (OB).Male ICR mice were exposed to 0, 20, 60, or 150 ppm of 2E1H, 8 hours per day, for continuous 1 week, 1 month, or 3 months and sacrificed for histopathological evaluation of OE and OB. 2E1H inhalation induced inflammation, degeneration, necrosis, desquamation or disarranged alteration in OE after exposure for 1 week and 3 months, and 3-month exposure resulted in the subsequent alteration in the number of functional cell components in OB which olfactory nerves innervate. Thus it might be suggested that the findings were associated with 2E1H-induced SBS.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2011 -2012 
    Author : ITO Yuki
     
    Diesel exhaust is a main airborne contaminant and includes many nanoparticles. Little studies reporting effects of nanoparticle-rich diesel exhaust (NR-DE) on liver have been conducted. In the present study, DNA microarray analysis showed that about 140 μg/m^3NR-DE for 1 month exposure caused the disruption of lipid homeostasis in rats. Additionally, exposure of NR-DE and filtered NR-DE, i.e. NR-DE without nanoparticles, increased hepatic fatty acids in mice. These results suggest that diesel exhaust induces the disturbance of lipid homeostasis and the main player exist in gas component in diesel exhaust.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2008 -2010 
    Author : ITO YUKI
     
    Diesel exhaust is a main airborne contaminant and includes many nanoparticles. The effects of nanoparticle-rich diesel exhaust (NR-DE) on liver in male rats were investigated in this study. Exposure conditions were chosen according to environmental fate of diesel exhaust. NR-DE at the concentrations near the value of environmental standard for 1 month induced hepatic inflammation which did not persist. It was suggested that the nuclear receptor in the liver played a role in this inflammation.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2008 -2010 
    Author : KAMIJIMA Michihiro; TAKAGI Kenji; UEYAMA Jun; NAKAJIMA Tamie; ITO Yuki; SHIBATA Eiji
     
    We developed and established highly sensitive methods of measuring urinary metabolites of organophosphorus and pyrethroid insecticides. The established methods were applied to general population and pesticide sprayers to evaluate their exposure. Furthermore, the relationship between metabolite body burden and male reproductive dysfunction was investigated. It was suggested that evaluation of single insecticide metabolite might lead to underestimation of risk of pesticide exposure.
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2007 -2008 
    Author : 伊藤 由起
     
    浮遊粒子状物質の一つであるディーゼル排気微粒子は、大気汚染の主要成分であり、呼吸器系・循環器系・免疫系・生殖器系への影響を及ぼすことが明らかにされている。ディーゼル排気ガスにはさまざまな粒径の粒子が含まれており、体内での挙動は粒径により異なるが、ディーゼル排気中のナノ粒子(ナノDEP)の毒性は未だほとんど明らかになっていない。ナノDEPの長期曝露に伴う動脈硬化の発症も危惧されていることから、動脈硬化に関係のあるperoxisome proliferator activated receptor alpha (PPARα)に注目し、肝臓での脂質代謝と動脈での炎症を検討した。対照群(13.61μg/m^3)と、粒径23〜27nmのナノ粒子を含む24.49、36.25、133.69μg/m^3を、7週齢雄性F344ラットに1日5時間、週5日間、1カ月、2か月、3ケ月間吸入曝露を行った。曝露終了後、ラットを曝露チャンバーから取り出し、血清、大動脈、肝臓を採取した。血清中の炎症マーカーは1カ月曝露後濃度依存的に上昇していた。脂質代謝と炎症の両面で動脈硬化に関わるPPARα-mRNAやそのタンパク量、脂質代謝に関わるPPARα標的遺伝子-mRNAは肝臓で1ケ月曝露後のみ誘導されていたが、2ケ月、3ケ月曝露後変化は見られなかった。一方動脈中のTNFα-mRNAは、2ケ月、3ケ月曝露後濃度依存的に上昇していた。ナノDEP曝露によりPPARαは早期に誘導されるものの、その標的遺伝子が誘導されないため、脂質代謝の促進や抗炎症作用が十分に発揮されず、3ケ月曝露により中性脂肪の蓄積と動脈での炎症が始まるのではないかと考えられた。

Committee Membership

  • 2023/03 - Today   Japan Society for Occupational Health   Recommendation for OELs Committee

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