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吉田 宗徳ヨシダ ムネノリ

所属部署医学研究科視覚科学分野
職名病院教授
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Last Updated :2020/06/02

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  • Flattening of retinal pigment epithelial detachments after pneumatic displacement of submacular hemorrhages secondary to age-related macular degeneration., Kimura M, Yasukawa T, Shibata Y, Kato A, Hirano Y, Uemura A, Yoshida M, Ogura Y, Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 256, (10) 1823 - 1829,   2018年10月, 査読有り
  • Peripheral Microvascular Abnormalities Detected by Wide-Field Fluorescein Angiography in Eyes with Branch Retinal Vein Occlusion., Yasuda Y, Hirano Y, Esaki Y, Tomiyasu T, Suzuki N, Yasukawa T, Yoshida M, Ogura Y, Ophthalmic research, 1 - 8,   2018年05月, 査読有り
  • Less Expansion of Short-Pulse Laser Scars in Panretinal Photocoagulation for Diabetic Retinopathy., Higaki M, Nozaki M, Yoshida M, Ogura Y, Journal of ophthalmology, 2018,   2018年, 査読有り
  • Evaluation of Navigated Laser Photocoagulation (Navilas 577+) for the Treatment of Refractory Diabetic Macular Edema., Kato F, Nozaki M, Kato A, Hasegawa N, Morita H, Yoshida M, Ogura Y, Journal of ophthalmology, 2018,   2018年, 査読有り
  • Six-month results of intravitreal ranibizumab for macular edema after branch retinal vein occlusion in a single-center prospective study: visual outcomes and microaneurysm formation., Kawamura M, Hirano Y, Yoshida M, Mizutani T, Sugitani K, Yasukawa T, Ogura Y, Clinical ophthalmology (Auckland, N.Z.), 12, 1487 - 1494,   2018年, 査読有り
  • Wide-field fluorescein and indocyanine green angiography findings in the eyes with Vogt-Koyanagi-Harada disease., Kurobe R, Hirano Y, Niwa N, Sugitani K, Yasukawa T, Yoshida M, Ogura Y, Journal of ophthalmic inflammation and infection, 7, (1) ,   2017年12月, 査読有り
  • Retinal Hemodynamics Seen on Optical Coherence Tomography Angiography Before and After Treatment of Retinal Vein Occlusion, Norihiro Suzuki, Yoshio Hirano, Taneto Tomiyasu, Yuya Esaki, Akiyoshi Uemura, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57, (13) 5681 - 5687,   2016年10月, 査読有り, PURPOSE. This study evaluates the retinal hemodynamics using optical coherence tomography angiography (OCTA) before and after anti-vascular endothelial growth factor (VEGF) therapy in patients with macular edema associated with retinal vein occlusion (RVO). METHODS. Twelve patients (23 eyes; mean age, 64 years) were included (eight eyes with branch RVO, four with central RVO, and 11 unaffected fellow eyes. The best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were measured before and 6 months after treatment. The foveal avascular zone (FAZ), nonperfused areas (NPAs), and flow area were evaluated with OCTA before and after treatment. RESULTS. The BCVA and CRT improved significantly after treatment. In eyes with RVO, the baseline FAZ in the retinal deep capillary layer was larger than in fellow eyes and enlarged in the retinal superficial and deep capillary layers after therapy; NPAs decreased after therapy, especially in the retinal deep capillary layer; and the baseline flow area was smaller than in fellow eyes and improved after therapy, especially in the retinal deep capillary layer. CONCLUSIONS. Optical coherence tomography angiography can evaluate the retinal hemodynamics in patients with RVOs. Anti-VEGF therapy reduced the NPA size and improved retinal blood flow, especially in the retinal deep layer. The current results suggested that anti-VEGF therapy might improve retinal deep ischemia in patients with RVO in the retinal deep layer, which is abundant in capillaries.
  • Microaneurysms cause refractory macular edema in branch retinal vein occlusion, Taneto Tomiyasu, Yoshio Hirano, Munenori Yoshida, Norihiro Suzuki, Takeshi Nishiyama, Akiyoshi Uemura, Tsutomu Yasukawa, Yuichiro Ogura, SCIENTIFIC REPORTS, 6,   2016年07月, 査読有り, Intravitreal anti-vascular endothelial growth factor (VEGF) agents can treat macular edema (ME) in branch retinal vein occlusion (BRVO). However, refractory ME, the mechanism of which is not well elucidated, occurs frequently. Sixty-six eyes with ME secondary to BRVO were enrolled in this retrospective observational case-control study. Twenty eyes received a sub-Tenon's capsule injection of triamcinolone acetonide (STTA), 22 eyes an intravitreal anti-VEGF injection (ranibizumab), 16 eyes were switched from STTA to ranibizumab, 4 eyes underwent vitrectomy, and 4 eyes were untreated. Multiple regression analysis and multivariate logistic regression analysis were conducted, respectively, to identify independent predictors of visual acuity (VA) prognosis and risk factors for refractory ME longer than 1 year. The mechanism of refractory ME and therapeutic approaches for identified risk factors also were investigated. Thirty-four (52%) eyes had refractory ME for over 1 year. Microaneurysms were identified as risk factors for refractory ME, leading to poor final VA. Ranibizumab suppressed microaneurysm formation and refractory ME, with early administration more effective. For already formed microaneurysms, laser photocoagulation reduced additional treatments. Microaneurysms may cause refractory ME in BRVO. Alternative therapy to suppress microaneurysms should be considered to prevent refractory ME in patients with BRVO.
  • Characteristics of Polypoidal Choroidal Vasculopathy Evaluated by Optical Coherence Tomography Angiography, Taneto Tomiyasu, Miho Nozaki, Munenori Yoshida, Yuichiro Ogura, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57, (9) OCT324 - OCT330,   2016年07月, 査読有り, PURPOSE. The purpose of this study was to compare the angiographic findings of polypoidal choroidal vasculopathy (PCV) detected by indocyanine green angiography (ICGA) and en face optical coherence tomography angiography (OCTA). METHODS. The study design was a retrospective chart review of 20 eyes with a clinical diagnosis of treatment-naive PCV, seen at Nagoya City University Hospital between December 2014 and January 2016. Indocyanine green angiography was performed with Heidelberg Retina Angiography 2 and OCTA was performed by using Avanti RTVue XR. RESULTS. Twenty eyes of 20 patients (18 male, 2 female) were studied. Average age was 71.9 years. Manual segmentation was required to detect the pathologic lesions of PCV in all cases. The polypoidal lesions were detected in 20 eyes (100%) by ICGA, and in 17 eyes (85%) by OCTA. The number of polypoidal lesions detected by OCTA averaged 2.6 +/- 1.9, with an average of 2.0 +/- 1.1 by ICGA (P < 0.05). The branching vascular network (BVN) was detected in 14 eyes (70%) by ICGA and in 14 eyes (70%) by OCTA. All of the BVNs detected by OCTA were located between the RPE and Bruch's membrane. CONCLUSIONS. Despite the manual segmentation required, en face OCTA enabled us to analyze the angiographic features of PCV combined with longitudinal image (B-scan). En face OCTA may be useful for understanding the pathogenesis of PCV and managing PCV.
  • New Insights Into Microaneurysms in the Deep Capillary Plexus Detected by Optical Coherence Tomography Angiography in Diabetic Macular Edema, Norio Hasegawa, Miho Nozaki, Noriaki Takase, Munenori Yoshida, Yuichiro Ogura, INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 57, (9) OCT348 - OCT355,   2016年07月, 査読有り, PURPOSE. To study the association between the distributions of microaneurysms detected by en face optical coherence tomography angiography (OCTA) and diabetic macular edema (DME). METHODS. The study design was a retrospective chart review of 27 patients (33 eyes) with DME. The eyes were scanned using OCTA (6 x 6 mm) and spectral-domain (SD) OCT macular cube. Each of the images of the capillary plexus was overlaid onto the image of the topographic map, and the densities of the microaneurysms were measured by ImageJ software. The association between the distribution of microaneurysms and macular edema was evaluated. RESULTS. For microaneurysms in areas with and without edema, 77.3 +/- 8.1% of these microaneurysms were located in the deep capillary plexuses (DCP). However, in areas of edema where the retinal thickness was more than 400 mu m, 91.3 +/- 9.1% of the microaneurysms were found in the DCP. This difference was statistically significant (P < 0.001). In the macular edema area, there was a significantly higher density of microaneurysms in the DCP compared to the superficial capillary plexuses (1.71/mm(2) vs. 0.17/mm(2), P < 0.001). There was also a significant correlation between the macular volume and the density of microaneurysms in the DCP in edema (r = 0.63, P < 0.001). CONCLUSIONS. Our study demonstrated a high proportion of microaneurysms in the DCP, as well as a novel association between the distributions of microaneurysms detected by OCTA and DME. Results also indicated that microaneurysms located in the DCP contribute to the pathogenesis of DME.
  • Value of OCT Angiography in the Diagnosis of Choroidal Neovascularization Complicating Multiple Evanescence White Dot Syndrome, Miho Nozaki, Satoshi Hamada, Masayo Kimura, Munenori Yoshida, Yuichiro Ogura, OPHTHALMIC SURGERY LASERS & IMAGING RETINA, 47, (6) 580 - 584,   2016年06月, 査読有り, This report describes a 19-year-old patient with the rare association of multiple evanescent white dot syndrome (MEWDS) and choroidal neovascularization (CNV). Despite the initial diagnosis of MEWDS, her vision significantly decreased. Fluorescein angiography showed dye leakage and pooling at the macula, whereas optical coherence tomography (OCT) showed cystoid macular edema and serous neuroepithelial elevation. The dye leakage and pooling made it impossible to diagnose CNV. However, OCT angiography (OCTA) revealed a vascular structure in the outer retina, thereby leading to the CNV diagnosis. Visual acuity improved after an anti-vascular endothelial growth factor injection. OCTA proved to be useful in the diagnosis of CNV.
  • Microvascular Abnormalities on Optical Coherence Tomography Angiography in Macular Edema Associated With Branch Retinal Vein Occlusion, Norihiro Suzuki, Yoshio Hirano, Munenori Yoshida, Taneto Tomiyasu, Akiyoshi Uemura, Tsutomu Yasukawa, Yuichiro Ogura, AMERICAN JOURNAL OF OPHTHALMOLOGY, 161, 126 - 132,   2016年01月, 査読有り, PURPOSE: To determine the ability of optical coherence tomography (OCT) angiography to image the microvascular structures compared with fluorescein angiography (FA) in patients with macular edema associated with branch retinal vein occlusion (BRVO). DESIGN: Retrospective, observational, consecutive case series. METHODS: Twenty-eight eyes of 27 patients (14 men, 13 women; mean age, 68.4 years) with macular edema associated with BRVO were enrolled. Simultaneous OCT angiography and FA were performed in all patients to evaluate the microvascular abnormalities and nonperfused areas. RESULTS: OCT angiography detected nonperfused areas in 28 eyes and FA in 18 eyes. The respective findings of superficial capillary telangiectasias by OCT angiography and FA were 13 and 11 eyes, for deep capillary telangiectasias 28 eyes and 11 eyes, for collateral vessels 18 eyes and 16 eyes, and for microaneurysms 13 eyes and 14 eyes. OCT angiography facilitated differential layer analysis of microaneurysms and collaterals as well as capillary telangiectasias in the retina. CONCLUSIONS: OCT angiography can visualize microvascular abnormalities equally well or better than FA in eyes with BRVO. Multimodal imaging using OCT angiography and FA can be a powerful tool to evaluate the pathology in BRVO. (C) 2016 by Elsevier Inc. All rights reserved.
  • [Ultra-wide Field Scanning Laser Ophthalmoscope]., Yoshida M, Nippon Ganka Gakkai zasshi, 120, (1) 3 - 4,   2016年01月, 査読有り
  • Wide-field optical coherence tomography angiography using extended field imaging technique to evaluate the nonperfusion area in retinal vein occlusion., Kimura M, Nozaki M, Yoshida M, Ogura Y, Clinical ophthalmology (Auckland, N.Z.), 10, 1291 - 1295,   2016年, 査読有り
  • Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration., Suetsugu T, Kato A, Yoshida M, Yasukawa T, Nishiwaki A, Hasegawa N, Usui H, Ogura Y, Clinical ophthalmology (Auckland, N.Z.), 10, 2497 - 2503,   2016年, 査読有り
  • ENLARGEMENT OF FOVEAL AVASCULAR ZONE IN DIABETIC EYES EVALUATED BY EN FACE OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY., Takase N, Nozaki M, Kato A, Ozeki H, Yoshida M, Ogura Y, Retina (Philadelphia, Pa.), 35, (11) 2377 - 2383,   2015年11月, 査読有り
  • [Evaluation of Diabetic Retinopathy with Ultra-wide Field Fluorescein Angiography]., Tomiyasu T, Hirahara S, Nozaki M, Yoshida M, Ogura Y, Nippon Ganka Gakkai zasshi, 119, (11) 807 - 811,   2015年11月, 査読有り
  • Intravitreal ranibizumab for patients with neovascular age-related macular degeneration with good baseline visual acuity., Kato A, Yasukawa T, Suga K, Hirano Y, Nozaki M, Yoshida M, Ogura Y, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 233, (1) 27 - 34,   2015年, 査読有り
  • Indocyanine Green Angiography-Guided Focal Laser Photocoagulation for Diabetic Macular Edema., Ogura S, Yasukawa T, Kato A, Kuwayama S, Hamada S, Hirano Y, Uemura A, Yoshida M, Ogura Y, Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde, 234, (3) 139 - 150,   2015年, 査読有り
  • Wide-Field Fundus Autofluorescence Imaging to Evaluate Retinal Function in Patients With Retinitis Pigmentosa, Shuntaro Ogura, Tsutomu Yasukawa, Aki Kato, Hideaki Usui, Yoshio Hirano, Munenori Yoshida, Yuichiro Ogura, AMERICAN JOURNAL OF OPHTHALMOLOGY, 158, (5) 1093 - 1098,   2014年11月, 査読有り, PURPOSE: To study the correlation between the visual fields (VF) and wide-field fundus autofluorescence (FAF) in patients with retinitis pigmentosa (RP). DESIGN: Retrospective, observational, consecutive case series. METHODS: Twenty-four eyes of 12 patients diagnosed with RP were enrolled. The VFs measured by Goldmann perimetry and wide-field FAF images were compared for each eye. The relationship between the areas of hypoautofluorescence on the wide-field FAF images and scotoma on Goldmann perimetry were evaluated. The VF and FAF images in the central 60 degrees were trimmed and superimposed to calculate the percentage agreement between the hypoautofluorescence and the scotomas and between the isoautofluorescence and hyperautofluorescence and the remaining VFs. RESULTS: The areas of hypoautofluorescence on the FAF images were correlated significantly (R = 0.86, P < .001) with the areas of the VF defects on Goldmann perimetry. The mean percentage agreement between the hypoautofluorescence and the scotomas was 91.0% +/- 7.7% and that of the isoautofluorescence and hyperautofluorescence with the remaining VFs was 84.5% +/- 7.4%. The areas of geographic hypoautofluorescence with or without hyperautofluorescent bands reflected the VF defects, while nummular or mottled hypoautofluorescence without VF defects was seen in 7 eyes. CONCLUSIONS: These results suggested that wide-field FAF imaging is useful to evaluate the remaining retinal function in patients with RP. Abnormal fundus autofluorescence precedes loss of retinal function and is helpful for monitoring disease progression. (C) 2014 by Elsevier Inc. All rights reserved.
  • [Comparison of outcomes of conventional laser versus pascal laser for diabetic retinopathy]., Yamakawa M, Nozaki M, Sato R, Morita H, Yoshida M, Ogura Y, Nippon Ganka Gakkai zasshi, 118, (4) 362 - 367,   2014年04月, 査読有り
  • Recovery of retinal pigment epithelium correlating with restoration of retinal sensitivity in eyes with a retinal pigment epithelial tear, Yoshio Hirano, Tsutomu Yasukawa, Takeshi Mizutani, Munenori Yoshida, Yuichiro Ogura, ACTA OPHTHALMOLOGICA, 92, (1) 94 - 97,   2014年02月, 査読有り
  • A case of retinopathy of prematurity treated by pattern scan laser photocoagulation., Ota S, Nozaki M, Hirahara S, Hattori T, Yoshida M, Ogura Y, Clinical ophthalmology (Auckland, N.Z.), 8, 1409 - 1412,   2014年, 査読有り
  • Comparative study of the effects of room air and sulfur hexafluoride gas tamponade on functional and morphological recovery after macular hole surgery: a retrospective study., Usui H, Yasukawa T, Hirano Y, Morita H, Yoshida M, Ogura Y, Ophthalmic research, 50, (4) 227 - 230,   2013年, 査読有り
  • Pneumatic displacement of submacular hemorrhage with or without tissue plasminogen activator, Takeshi Mizutani, Tsutomu Yasukawa, Yuya Ito, Ayae Takase, Yoshio Hirano, Munenori Yoshida, Yuichiro Ogura, GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 249, (8) 1153 - 1157,   2011年08月, 査読有り, To assess the efficacy and complications of intravitreal injection of sulfur hexafluoride (SF(6)) gas with/without tissue plasminogen activator (tPA) for displacing submacular hemorrhage. The medical records of 53 eyes that underwent pneumatic displacement for submacular hemorrhage were reviewed retrospectively. Submacular hemorrhage was related to exudative age-related macular degeneration (AMD) in 39 eyes and ruptured retinal arterial macroaneurysms in 14 eyes, and treated with intravitreal injection of SF(6) gas with or without tPA. Compared with preoperatively (mean follow-up, 18.4 months), the final visual acuity (VA) improved by 0.3 or more logMAR unit in 34 eyes (64.2%), stabilized within 0.3 logMAR in 15 eyes (28.3%), and deteriorated in four eyes (7.5%). In eyes with AMD, hemorrhage including vitreous hemorrhage recurred in eight (22.2%) of 36 eyes treated with tPA and one (33.3%) of three eyes not treated with tPA. In eyes with macroaneurysms, hemorrhage recurred in four (100%) of four eyes treated with tPA and in one (10.0%) of ten eyes without tPA (p < 0.005). Eight eyes underwent vitrectomy for recurrent hemorrhage. During follow-up, photodynamic therapy or intravitreal ranibizumab or pegaptanib was administered in 16 (41.0%) of 39 eyes with AMD. Postoperative ocular hypertension persisting over 3 days was not observed. Intravitreal SF(6) gas plus tPA may be well-accepted, with good visual outcomes and no remarkable complications for treating submacular hemorrhage secondary to AMD. tPA is not recommended for ruptured retinal arterial macroaneurysms, because of a higher incidence of subsequent vitreous hemorrhage. Pneumatic displacement of submacular hemorrhage without tPA may provide good visual outcomes with less re-bleeding.
  • [Long-term outcome of radiation therapy for exudative age-related macular degeneration in Japan]., Mizutani T, Yasukawa T, Tokoro M, Yoshida M, Ogura Y, Nippon Ganka Gakkai zasshi, 115, (8) 681 - 685,   2011年08月, 査読有り
  • Outcomes and Complications of 25-Gauge Transconjunctival Sutureless Vitrectomy for Proliferative Diabetic Retinopathy, Daisuke Ozone, Yoshio Hirano, Jiro Ueda, Tsutomu Yasukawa, Munenori Yoshida, Yuichiro Ogura, OPHTHALMOLOGICA, 226, (2) 76 - 80,   2011年, 査読有り, Purpose: To investigate the feasibility and efficacy of 25-gauge vitrectomy in the treatment of proliferative diabetic retinopathy (PDR). Methods: All patients underwent primary 25-gauge vitrectomy for simple vitreous hemorrhage (VH), fibrovascular proliferation (FVP), or tractional retinal detachment (TD), and were followed for more than 1 month. Final visual outcomes and intraoperative and postoperative complications were evaluated. Results: 167 eyes (138 patients) were used in this study, 65 eyes (39%) with VH, 66 eyes (40%) with FVP, and 36 eyes (21%) with TD. Measured using the mean logarithm of the minimum angle of resolution (logMAR), visual acuity (VA) significantly improved (p < 0.0001). Intraoperative iatrogenic retinal breaks developed in 19 eyes (11%). Concerning postoperative complications, VH in 36 eyes (22%), retinal detachment in 2 eyes (1%), and neovascular glaucoma 12 eyes (7%) were observed. No endophthalmitis developed. Conclusions: Twenty-five-gauge vitrectomy can successfully treat PDR. Clinical outcomes and complications are comparable to those of 20-gauge vitrectomy. Copyright (C) 2011 S. Karger AG, Basel
  • Multicenter Survey with a Systematic Overview of Acute-Onset Endophthalmitis after Transconjunctival Microincision Vitrectomy Surgery, Yusuke Oshima, Kazuaki Kadonosono, Hidetaka Yamaji, Makoto Inoue, Munenori Yoshida, Hideya Kimura, Masahito Ohji, Fumio Shiraga, Toshimitsu Hamasaki, AMERICAN JOURNAL OF OPHTHALMOLOGY, 150, (5) 716 - 725,   2010年11月, 査読有り, PURPOSE: To explore the incidence and visual outcomes of acute-onset endophthalmitis after transconjunctival microincision vitrectomy surgery (MIVS). DESIGN: Retrospective, interventional, multicenter survey with a systematic review. METHODS: A clinical database search was performed at 27 institutions involving 43 868 consecutive patients who underwent vitrectomy between November 2003 and October 2008 to identify all patients with endophthalmitis after vitrectomy. A systematic review of studies reporting the endophthalmitis rates after MIVS versus 20-gauge vitrectomy was conducted to assess the pooled incidence rates of postvitrectomy endophthalmitis. RESULTS: The endophthalmitis rates from the multicenter survey were 0.034% (10 cases per 29 030 eyes) after 20-gauge vitrectomy and 0.054% (8 cases per 14 838 eyes) after MIVS, with no significant (P = .603) differences between groups. Although the incidence in 25-gauge cases (6 per 8238 eyes; 0.073%) was greater than in 23-gauge cases (2 per 6600 eyes; 0.030%), the difference was not significant (P = 0.451). Of 8 eyes in which endophthalmitis developed after MIVS, 6 eyes (75%) had a final visual acuity of 0.5 or better, and none lost light perception. By combining the results of 7 studies, including the current multicenter survey, meta-analyses from a total of 77 956 cases at the baseline showed that the pooled endophthalmitis rates after MIVS (0.08%; 95% confidence interval, 0.030% to 0.164%) and after 20-gauge vitrectomy (0.030%; 95% confidence interval, 0.012% to 0.048%) did not differ significantly (P = .207, pooled risk difference; 0.0005 [95% confidence interval, -0.0002 to 0.0012]). CONCLUSIONS: The incidence of postvitrectomy endophthalmitis was low with no significant differences between MIVS and 20-gauge vitrectomy. (Am J Ophthalmol 2010;150:716-725. (C) 2010 by Elsevier Inc. All rights reserved.)
  • Unilateral Acute Retinal Necrosis 2 Months After Herpes Simplex Encephalitis., Sugitani K, Hirano Y, Yasukawa T, Yoshida M, Ogura Y, Ophthalmic surgery, lasers & imaging : the official journal of the International Society for Imaging in the Eye, 1 - 5,   2010年03月, 査読有り
  • Intraocular pressure elevation following triamcinolone acetonide administration as related to administration routes, Yoshio Hirano, Takeshi Ito, Miho Nozaki, Tsutomu Yasukawa, Eiji Sakurai, Munenori Yoshida, Yuichiro Ogura, JAPANESE JOURNAL OF OPHTHALMOLOGY, 53, (5) 519 - 522,   2009年09月, 査読有り, To evaluate the incidence and risk factors of intraocular pressure (IOP) elevation following triamcinolone acetonide (TA) administration. In this retrospective observational case series, patients (224 eyes of 202 patients) with diffuse diabetic macular edema (66 eyes), branch retinal vein occlusion (39 eyes), central retinal vein occlusion (25 eyes), exudative age-related macular degeneration (49 eyes), myopic choroidal neovascularization (10 eyes), uveitis (30 eyes), or other conditions (5 eyes) were administered an intravitreal or posterior sub-Tenon capsule injection, or both, of TA. Sub-Tenon capsule injection was performed on 106 eyes (STTA group). Intravitreal injection was performed on 118 eyes (IVTA group), of which 85 eyes underwent simultaneous intravitreal and sub-Tenon capsule injections. Mean follow-up after TA administration was 15.9 +/- 10.4 (range, 3-39) months. The sub-Tenon capsule injection and intravitreal injection of TA were compared with respect to the frequency of IOP elevation and the time between TA administration and the initial IOP elevation, and the possible risk factors responsible for IOP elevation were identified. There was no significant difference in frequency of IOP > 21 mmHg between the STTA group and the IVTA group (P = 0.0588). There was, however, a significant difference in the frequency of IOP > 30 mmHg between the two groups (P = 0.0004). In the IVTA group, more patients needed antiglaucoma medication than in the STTA group (P = 0.0052). The incidence rate of IOP elevation within 1 week after TA administration in the IVTA group was significantly higher than in the STTA group (P = 0.0154). Risk factors for IOP elevation included higher baseline IOP (P < 0.0001), younger patients (P = 0.0095), and simultaneous administration of sub-Tenon capsule and intravitreal injections (P = 0.0228). Careful follow-up of IOP is required after TA injections.
  • Pitavastatin Attenuates Leukocyte-Endothelial Interactions Induced by Ischemia-Reperfusion Injury in the Rat Retina, Kenichi Miyaki, Akihisa Matsubara, Akiko Nishiwaki, Kazuyuki Tomida, Hiroshi Morita, Munenori Yoshida, Yuichiro Ogura, CURRENT EYE RESEARCH, 34, (1) 10 - 17,   2009年, 査読有り, Purpose: Statins (3-hydroxy-methylglutaryl coenzyme A reductase inhibitors) have been shown to lower serum cholesterol levels in clinical use. Moreover, it has been reported that statins exert pleiotropic and beneficial effects on vascular endothelium. Therefore, we investigated the effects of pitavastatin, a new statin, on leukocyte accumulation during ischemia-reperfusion injury. Materials and Methods: Transient retinal ischemia was induced in Long-Evans rats for 60 min by temporal ligation of the optic nerve. Pitavastatin (0.12, 0.35, or 1.1 mg/kg) was administered 5 min prior to the induction of retinal ischemia. Leukocyte-endothelial interactions in the post-ischemic retina were evaluated in vivo with acridine orange digital fluorography. The number of rolling leukocytes, number of accumulated leukocytes, and diameters of the major retinal artery and vein were evaluated. Intercellular adhesion molecule-1 (ICAM-1) mRNA expression in the retina was semiquantitatively studied using the RT-PCR method. Results: Pitavastatin-treated rats at doses of 0.35 and 1.1 mg/kg showed mild arterial narrowing (p 0.01) and venous dilation (p 0.01) compared with vehicle-treated (ischemic) rats. In rats treated with 0.35 mg/kg pitavastatin, the number of rolling leukocytes was significantly reduced by 35.5% (p 0.01) 12 hr after reperfusion compared with that of vehicle-treated rats. With treatment at a dose of 0.35 mg/kg pitavastatin, the number of accumulated leukocytes was reduced to 68.7% (p 0.01) 24 hr after reperfusion. Moreover, pitavastatin treatment significantly reduced ICAM-1 mRNA expression in the retina during ischemia-reperfusion injury. Conclusions: Pitavastatin effectively attenuated ischemia-induced leukocyte-endothelial interactions in the rat retina.
  • [Incidence of posterior subcapsular cataract progression after triamcinolone acetonide administration]., Yoshimura M, Hirano Y, Nozaki M, Yoshida M, Ogura Y, Nippon Ganka Gakkai zasshi, 112, (9) 786 - 789,   2008年09月, 査読有り
  • Comparative study on efficacy of a combination therapy of triamcinolone acetonide administration with and without vitrectomy for macular edema associated with branch retinal vein occlusion, Yoshio Hirano, Eiji Sakurai, Munenori Yoshida, Yuichiro Ogura, OPHTHALMIC RESEARCH, 39, (4) 207 - 212,   2007年, 査読有り, Aims: To compare the efficacy of a combination therapy of triamcinolone acetonide (TA) administration with and without vitrectomy in eyes with macular edema associated with branch retinal vein occlusion over a 1-year period. Methods: A retrospective, case-control study was conducted in 15 eyes of 15 patients with macular edema associated with branch retinal vein occlusion. Eight eyes underwent simultaneous intravitreal and posterior sub-Tenon capsule injections of TA (TA-injected group). Seven eyes underwent vitrectomy with intravitreal or simultaneous posterior sub-Tenon capsule injection of TA (vitrectomy with TA group). Macular thickness and visual acuity were measured before and at 1, 3, 6 and 12 months after the therapy. Results: Twelve months after the therapy, mean visual acuity improved significantly from baseline in both the TA-injected (p = 0.0069) and vitrectomy with TA groups (p = 0.0145). Macular thickness also improved significantly in both the TA-injected (p = 0.0065) and vitrectomy with TA groups (p = 0.0058). At 12 months after the therapy, there was no significant difference in visual acuity and macular thickness between the two groups (p = 0.3308 and 0.3711, respectively). At the early postoperative stage ( 1 and 3 months after the therapy), the central macular thickness in the TA-injected group was significantly less than that in the vitrectomy with TA group (p = 0.0140 and 0.0275, respectively); there was no significant difference in visual acuity between the two groups (p = 0.0796 and 0.3753, respectively). Conclusion: TA injection without vitrectomy was as effective as a combination therapy of TA injection with vitrectomy. Copyright (C) 2007 S. Karger AG, Basel
  • High glucose exacerbates neutrophil adhesion to human retinal endothelial cells, F Hirata, M Yoshida, Y Ogura, EXPERIMENTAL EYE RESEARCH, 82, (1) 179 - 182,   2006年01月, 査読有り, Leukocyte accumulation in the retina is thought to play a key role in the earl), stage of diabetic retinopathy. Leukocyte-endothelial adhesion is important for leukostasis, and high glucose levels may influence it. However, few studies have demonstrated leukocyte-endothelial adhesion using cultured human retinal endothelial cells (HRECs) after high glucose exposure. We report herein the results of neutrophil-endothelial adhesion assay after high glucose exposure. A high concentration of glucose (46.1 mM for 48 h) significantly increased neutrophil adhesion to HRECs as compared to controls. This phenomenon was blocked by PKC inhibitor and anti-intercellular adhesion molecule-1 antibody. Hyperosmolarity did not affect neutrophil-endothelial adhesion. These results suggested that glucose enhances neutrophil adhesion to HRECs through surface expression of ICAM-1 via activation of the PKC pathway. (C) 2005 Elsevier Ltd. All rights reserved.
  • Insulin enhances leukocyte-endothelial cell adhesion in the retinal microcirculation through surface expression of intercellular adhesion molecule-1, F Hirata, M Yoshida, Y Niwa, M Okouchi, N Okayama, Y Takeuchi, M Itoh, Y Ogura, MICROVASCULAR RESEARCH, 69, (3) 135 - 141,   2005年05月, 査読有り, The purpose of this study was to evaluate the effects of insulin on leukocyte endothelial cell adhesion in the retinal microcirculation in vitro and in vivo. Human retinal endothelial cells (HRECs) were cultured in medium with or without insulin, and neutrophils allowed to adhere. Adherent neutrophils were quantified by measuring myeloperoxidase activity. Surface expression of endothelial adhesion molecules were studied with the use of an enzyme immunoassay. Insulin at concentrations of 50 and 100 mu U/ml significantly increased neutrophil adhesion to HRECs compared with the control cells (P < 0.01, respectively). Surface expression of intercellular adhesion molecule-1 (ICAM-1) significantly increased when HRECs were exposed to 100 mu U/ml insulin, as compared with the control cells (P < 0.05). Anti-ICAM-1 antibody significantly inhibited neutrophils adhesion to HRECs (P < 0.0001). Brown-Norway rats received subcutaneous injection of 0.2 U per 100 g body weight insulin three times. Control rats received the same amount of phosphate-buffered saline. Leukocyte entrapment in the retina was evaluated using acridine orange leukocyte fluorography. The number of leukocytes trapped in the retina of insulin-treated rats was significantly elevated compared with that in the control animals (P < 0.0001). These results suggested that insulin enhances leukostasis in retinal microcirculation. Hyperinsulinemia may be a risk factor of retinal microcirculatory disturbances. (c) 2005 Elsevier Inc. All rights reserved.


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