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山下 依子ヤマシタ ヨリコ

所属部署医学研究科共同研究教育センター
職名准教授
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Last Updated :2019/07/06

研究者基本情報

学位

  • 医学博士, 名古屋大学

所属学協会

  • 日本臨床細胞学会
  • 日本病理学会
  • 日本癌学会
  • United States and Canadian Academy of Pathology
  • 日本リンパ網内系学会

委員歴

  •   2015年 - 現在, 日本癌学会, 評議員
  •   2003年 - 現在, 日本病理学会, 学術評議員
  • 日本リンパ網内系学会, 評議員

経歴

  • 名古屋大学 大学院医学系研究科 機能構築医学専攻 大学院医学系研究科 機能構築医学専攻, 講師

研究活動情報

研究分野

  • 境界医学, 病態検査学
  • 基礎医学, 人体病理学
  • 基礎医学, 実験病理学

研究キーワード

    婦人科腫瘍, 酸化ストレス, 子宮内膜症, 卵巣癌, ヒト細胞の不死化と癌化, 悪性リンパ腫, EBウイルス, 遺伝子診断, プロテオーム

論文

  • N-acetylglucosaminyltransferase IVa promotes invasion of choriocarcinoma., Nishino K, Yamamoto E, Niimi K, Sekiya Y, Yamashita Y, Kikkawa F, Oncology reports, 38, (1) 440 - 448,   2017年07月, 査読有り
  • Mature cystic teratomas of the ovary., Yamashita Y, Human pathology, 64,   2017年06月, 査読有り
  • The NADPH Oxidase Inhibitor Apocynin Suppresses Preneoplastic Liver Foci of Rats., Fuji S, Suzuki S, Naiki-Ito A, Kato H, Hayakawa M, Yamashita Y, Kuno T, Takahashi S, Toxicologic pathology, 45, (4) 544 - 550,   2017年06月, 査読有り
  • Anti-N-methyl-d-aspartate receptor limbic encephalitis associated with mature cystic teratoma of the fallopian tube., Hattori Y, Yamashita Y, Mizuno M, Katano K, Sugiura-Ogasawara M, Matsukawa N, The journal of obstetrics and gynaecology research, 43, (2) 412 - 415,   2017年02月, 査読有り
  • Role of hemoglobin and transferrin in multi-wall carbon nanotube-induced mesothelial injury and carcinogenesis., Wang Y, Okazaki Y, Shi L, Kohda H, Tanaka M, Taki K, Nishioka T, Hirayama T, Nagasawa H, Yamashita Y, Toyokuni S, Cancer science, 107, (3) 250 - 257,   2016年03月, 査読有り
  • Pain-reducing anesthesia prevents oxidative stress in human term placenta., Tsuzuki Y, Yamashita Y, Hattori Y, Hua Li G, Akatsuka S, Kotani T, Kikkawa F, Naiki-Ito A, Takahashi S, Nishiwaki K, Toyokuni S, Journal of clinical biochemistry and nutrition, 58, (2) 156 - 160,   2016年03月, 査読有り
  • Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis., Kato H, Naiki-Ito A, Naiki T, Suzuki S, Yamashita Y, Sato S, Sagawa H, Kato A, Kuno T, Takahashi S, Oncotarget, 7, (2) 2009 - 2021,   2016年01月, 査読有り
  • Connexin 32 and luteolin play protective roles in non-alcoholic steatohepatitis development and its related hepatocarcinogenesis in rats., Sagawa H, Naiki-Ito A, Kato H, Naiki T, Yamashita Y, Suzuki S, Sato S, Shiomi K, Kato A, Kuno T, Matsuo Y, Kimura M, Takeyama H, Takahashi S, Carcinogenesis, 36, (12) 1539 - 1549,   2015年12月, 査読有り
  • Ovarian cancer: new developments in clear cell carcinoma and hopes for targeted therapy., Yamashita Y, Japanese journal of clinical oncology, 45, (5) 405 - 407,   2015年05月, 査読有り
  • Napsin A is a specific marker for ovarian clear cell adenocarcinoma., Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 28, (1) 111 - 117,   2015年01月, 査読有り
  • Usefulness of immunohistochemistry for the detection of the BRAF V600E mutation in ovarian serous borderline tumors., Hayashi Y, Sasaki H, Takeshita S, Nishikawa R, Nishikawa H, Arakawa A, Yamashita Y, Takahashi S, Sugiura-Ogasawara M, Oncology reports, 32, (5) 1815 - 1819,   2014年11月, 査読有り
  • Connective tissue growth factor and β-catenin constitute an autocrine loop for activation in rat sarcomatoid mesothelioma., Jiang L, Yamashita Y, Chew SH, Akatsuka S, Ukai S, Wang S, Nagai H, Okazaki Y, Takahashi T, Toyokuni S, The Journal of pathology, 233, (4) 402 - 414,   2014年08月, 査読有り
  • Lack of presence of the human cytomegalovirus in human glioblastoma., Yamashita Y, Ito Y, Isomura H, Takemura N, Okamoto A, Motomura K, Tsujiuchi T, Natsume A, Wakabayashi T, Toyokuni S, Tsurumi T, Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 27, (7) 922 - 929,   2014年07月, 査読有り
  • Expression of chromobox homolog 7 (CBX7) is associated with poor prognosis in ovarian clear cell adenocarcinoma via TRAIL-induced apoptotic pathway regulation., Shinjo K, Yamashita Y, Yamamoto E, Akatsuka S, Uno N, Kamiya A, Niimi K, Sakaguchi Y, Nagasaka T, Takahashi T, Shibata K, Kajiyama H, Kikkawa F, Toyokuni S, International journal of cancer, 135, (2) 308 - 318,   2014年07月, 査読有り
  • Ovarian mucinous tumors arising from mature cystic teratomas--a molecular genetic approach for understanding the cellular origin., Fujii K, Yamashita Y, Yamamoto T, Takahashi K, Hashimoto K, Miyata T, Kawai K, Kikkawa F, Toyokuni S, Nagasaka T, Human pathology, 45, (4) 717 - 724,   2014年04月, 査読有り
  • Establishment of an invasive prostate cancer model in transgenic rats by intermittent testosterone administration., Sato S, Suzuki S, Naiki-Ito A, Komiya M, Ne L, Kato H, Sagawa H, Yamashita Y, Shirai T, Takahashi S, Journal of toxicologic pathology, 27, (1) 43 - 49,   2014年04月, 査読有り
  • Cancer-promoting role of adipocytes in asbestos-induced mesothelial carcinogenesis through dysregulated adipocytokine production., Chew SH, Okazaki Y, Nagai H, Misawa N, Akatsuka S, Yamashita K, Jiang L, Yamashita Y, Noguchi M, Hosoda K, Sekido Y, Takahashi T, Toyokuni S, Carcinogenesis, 35, (1) 164 - 172,   2014年01月, 査読有り
  • Preclinical evaluation of an O(6)-methylguanine-DNA methyltransferase-siRNA/liposome complex administered by convection-enhanced delivery to rat and porcine brains., Tsujiuchi T, Natsume A, Motomura K, Kondo G, Ranjit M, Hachisu R, Sugimura I, Tomita S, Takehara I, Woolley M, Barua NU, Gill SS, Bienemann AS, Yamashita Y, Toyokuni S, Wakabayashi T, American journal of translational research, 6, (2) 169 - 178,   2014年, 査読有り
  • Apocynin, an NADPH oxidase inhibitor, suppresses rat prostate carcinogenesis., Suzuki S, Shiraga K, Sato S, Punfa W, Naiki-Ito A, Yamashita Y, Shirai T, Takahashi S, Cancer science, 104, (12) 1711 - 1717,   2013年12月, 査読有り
  • β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5., Tokuda N, Numata S, Li X, Nomura T, Takizawa M, Kondo Y, Yamashita Y, Hashimoto N, Kiyono T, Urano T, Furukawa K, Furukawa K, Glycobiology, 23, (10) 1175 - 1183,   2013年10月, 査読有り
  • Met is the most frequently amplified gene in endometriosis-associated ovarian clear cell adenocarcinoma and correlates with worsened prognosis., Yamashita Y, Akatsuka S, Shinjo K, Yatabe Y, Kobayashi H, Seko H, Kajiyama H, Kikkawa F, Takahashi T, Toyokuni S, PloS one, 8, (3) ,   2013年, 査読有り
  • Iron overload signature in chrysotile-induced malignant mesothelioma., Jiang L, Akatsuka S, Nagai H, Chew SH, Ohara H, Okazaki Y, Yamashita Y, Yoshikawa Y, Yasui H, Ikuta K, Sasaki K, Kohgo Y, Hirano S, Shinohara Y, Kohyama N, Takahashi T, Toyokuni S, The Journal of pathology, 228, (3) 366 - 377,   2012年11月, 査読有り
  • The ferroimmunomodulatory role of ectopic endometriotic stromal cells in ovarian endometriosis., Kobayashi H, Yamashita Y, Iwase A, Yoshikawa Y, Yasui H, Kawai Y, Uchida K, Uno N, Akatsuka S, Takahashi T, Kikkawa F, Toyokuni S, Fertility and sterility, 98, (2) 415 - 22.e1,   2012年08月, 査読有り
  • Fenton reaction induced cancer in wild type rats recapitulates genomic alterations observed in human cancer., Akatsuka S, Yamashita Y, Ohara H, Liu YT, Izumiya M, Abe K, Ochiai M, Jiang L, Nagai H, Okazaki Y, Murakami H, Sekido Y, Arai E, Kanai Y, Hino O, Takahashi T, Nakagama H, Toyokuni S, PloS one, 7, (8) ,   2012年, 査読有り
  • Free calvarial periosteum graft vascularized by an omental flap in a rat model., Nakazato K, Toriyama K, Hishida M, Takanari K, Yagi S, Yamashita Y, Akatsuka S, Hayakawa A, Kamei Y, Annals of plastic surgery, 67, (6) 649 - 654,   2011年12月, 査読有り
  • Diameter and rigidity of multiwalled carbon nanotubes are critical factors in mesothelial injury and carcinogenesis., Nagai H, Okazaki Y, Chew SH, Misawa N, Yamashita Y, Akatsuka S, Ishihara T, Yamashita K, Yoshikawa Y, Yasui H, Jiang L, Ohara H, Takahashi T, Ichihara G, Kostarelos K, Miyata Y, Shinohara H, Toyokuni S, Proceedings of the National Academy of Sciences of the United States of America, 108, (49) E1330 - 8,   2011年12月, 査読有り
  • Age- and sun exposure-dependent differences in 8-hydroxy-2'-deoxyguanosine and N-(carboxymethyl)lysine in human epidermis., Toyokuni S, Hirao A, Wada T, Nagai R, Date A, Yoshii T, Akatsuka S, Yamashita Y, Kawada A, Journal of clinical biochemistry and nutrition, 49, (2) 121 - 124,   2011年09月, 査読有り
  • Spatiotemporally different DNA repair systems participate in Epstein-Barr virus genome maturation., Sugimoto A, Kanda T, Yamashita Y, Murata T, Saito S, Kawashima D, Isomura H, Nishiyama Y, Tsurumi T, Journal of virology, 85, (13) 6127 - 6135,   2011年07月, 査読有り
  • The human cytomegalovirus gene products essential for late viral gene expression assemble into prereplication complexes before viral DNA replication., Isomura H, Stinski MF, Murata T, Yamashita Y, Kanda T, Toyokuni S, Tsurumi T, Journal of virology, 85, (13) 6629 - 6644,   2011年07月, 査読有り
  • [Mechanisms of asbestos-induced carcinogenesis]., Toyokuni S, Jiang L, Hu Q, Nagai H, Okazaki Y, Akatsuka S, Yamashita Y, Nihon eiseigaku zasshi. Japanese journal of hygiene, 66, (3) 562 - 567,   2011年05月, 査読有り
  • Stage-specific roles of fibulin-5 during oxidative stress-induced renal carcinogenesis in rats., Ohara H, Akatsuka S, Nagai H, Liu YT, Jiang L, Okazaki Y, Yamashita Y, Nakamura T, Toyokuni S, Free radical research, 45, (2) 211 - 220,   2011年02月, 査読有り
  • Bevacizumab improves the delivery and efficacy of paclitaxel., Yanagisawa M, Yorozu K, Kurasawa M, Nakano K, Furugaki K, Yamashita Y, Mori K, Fujimoto-Ouchi K, Anti-cancer drugs, 21, (7) 687 - 694,   2010年08月, 査読有り
  • Preclinical study of prolonged administration of trastuzumab as combination therapy after disease progression during trastuzumab monotherapy., Fujimoto-Ouchi K, Sekiguchi F, Yamamoto K, Shirane M, Yamashita Y, Mori K, Cancer chemotherapy and pharmacology, 66, (2) 269 - 276,   2010年07月, 査読有り
  • Omental flap closure of refractory wounds: rat model., Hishida M, Toriyama K, Yamashita Y, Akatsuka S, Hayakawa A, Torii S, Kamei Y, Nagoya journal of medical science, 72, (1-2) 91 - 99,   2010年02月, 査読有り
  • Antitumor activity of bevacizumab in combination with capecitabine and oxaliplatin in human colorectal cancer xenograft models., Yanagisawa M, Fujimoto-Ouchi K, Yorozu K, Yamashita Y, Mori K, Oncology reports, 22, (2) 241 - 247,   2009年08月, 査読有り

MISC

  • 酸化ストレスと代謝変化, THE LUNG perspectives., 18,   2010年
  • Stage-specific roles of fibulin-5 during oxidative stress-induced renal carcinogenesis in rats., Free Radic Res., Epub ahead of print,   2010年
  • Novel Method for Efficient Collection of Normal Mesothelial Cells In Vivo, JIANG Li, YAMASHITA Yoriko, TOYOKUNI Shinya, Journal of Clinical Biochemistry and Nutrition, 46, (3) 265 - 268,   2010年
  • Homozygous deletion of CDKN2A/2B is a hallmark of iron-induced high-grade rat mesothelioma, HU Qian, HU Qian, AKATSUKA Shinya, YAMASHITA Yoriko, OHARA Hiroki, NAGAI Hirotaka, OKAZAKI Yasumasa, TAKAHASHI Takashi, TOYOKUNI Shinya, Laboratory Investigation, 90, (3) 360 - 373,   2010年
  • Efficient Production of Infectious Viruses Requires Enzymatic Activity of Epstein-Barr Virus Protein Kinase, MURATA Takayuki, ISOMURA Hiroki, YAMASHITA Yoriko, TOYAMA Shigenori, TOYAMA Shigenori, SATO Yoshitaka, NAKAYAMA Sanae, KUDOH Ayumi, IWAHORI Satoko, KANDA Teru, TSURUMI Tatsuya, TSURUMI Tatsuya, Virology, 389, (1-2) 75 - 81,   2009年
  • c-Maf Expression in Angioimmunoblastic T cell Lymphoma, American Journal of Surgical Pathology, 31, (11) 1695 - 702,   2007年
  • Diffuse large B-cell lymphoma initially manifesting in the bone marrow., Am J Clin Pathol., 127,   2007年
  • Hepatosplenic alphabeta T-cell lymphoma successfully treated with allogeneic bone marrow transplantation., Bone Marrow Transplant., 39,   2007年
  • Development-dependent expression of cyclin D3 in precursor T-cell lymphoblastic leukemia/lymphoma., SASAKI Eiichi, SASAKI Eiichi, YATABE Yasushi, HASHIMOTO Mitsuyoshi, YAMASHITA Yoriko, HASEGAWA Yuichi, KOJIMA Hiroshi, NAGASAWA Toshiro, MORI Naoyoshi, Pathol Int., 57, (2) 53 - 59,   2007年
  • Immortalization of Epstein-Barr virus-negative human B lymphocytes with minimal chromosomal instability., YAMASHITA Yoriko, TSURUMI Tatsuya, MORI Naoyoshi, KIYONO Tohru, Pathol Int., 56, (11) 659 - 667,   2006年
  • Loss of O6-methylguanine-DNA methyltransferase protein expression is a favorable prognostic marker in diffuse large B-cell lymphoma., OHNO Toshihito, HIRAGA Junji, OHASHI Haruhiko, SUGISAKI Chiho, LI Eika, ASANO Haruhiko, ITO Tastuya, NAGAI Hirokazu, YAMASHITA Yoriko, MORI Naoyoshi, KINOSHITA Tomohiro, NAOE Tomoki, Int J Hematol., 83, (4) 341 - 347,   2006年
  • Quantitative analysis of herpesvirus load in the lymph nodes of patients with histiocytic necrotizing lymphadenitis using a real-time PCR assay., Diagn Mol Pathol., 15, (1) 49 - 55,   2006年
  • Primary lymphoma arising in the nasal cavity among Japanese., Histopathology., 47,   2005年
  • Aggressive Lennert's lymphoma: report of three cases in comparison to non-aggressive Lennert's lymphoma., KITAMURA Atsuko, YAMASHITA Yoriko, SATO Yuji, HASEGAWA Yuichi, KOJIMA Hiroshi, NAGASAWA Toshiro, MORI Naoyoshi, Pathol Int., 55, (10) 626 - 631,   2005年
  • Clinicopathological features and prognostic factors of Japanese patients with "peripheral T-cell lymphoma, unspecified" diagnosed according to the WHO classification., Leuk Res., 28,   2004年
  • Rheumatoid arthritis with diffuse pulmonary rheumatoid nodules., KITAMURA A, MATSUNO T, NARITA M, SHIMOKATA K, YAMASHITA Y, MORI N, Pathol Int., 54, (10) 798 - 802,   2004年
  • Frequent expression of CD30 antigen in the primary gastric non-B, non-Hodgkin lymphomas., IWAMIZU‐WATANABE S, YAMASHITA Y, YATABE Y, NAKAMURA S, MORI N, Pathol Int., 54, (7) 503 - 509,   2004年
  • TIA-1 expression in hairy cell leukemia., Mod Pathol, 17,   2004年
  • ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC)., Mod Pathol., 16, (8) 828 - 32,   2003年
  • Nodal CD8 positive cytotoxic T-cell lymphoma: a distinct clinicopathological entity., Mod Pathol., 15, (11) 1131 - 9,   2002年
  • Immunohistochemical detection of CD79a expression in precursor T cell lymphoblastic lymphoma/leukaemias., J Pathol., 197,   2002年
  • Clinicopathological analyses of 5 Japanese patients with CD56+ primary cutaneous lymphomas., Int J Hematol., 72, (4) 477 - 83,   2000年
  • Lennert's lymphoma: a variant of cytotoxic T-cell lymphoma?, Am J Surg Pathol., 24,   2000年
  • Lymphomatous features of aggressive NK cell leukaemia/lymphoma with massive necrosis, haemophagocytosis and EB virus infection., Histopathology., 37,   2000年
  • Intestinal T-cell lymphoma probably of CD8alphaalpha lymphocyte derivation., Histopathology., 37,   2000年
  • Varied B-cell immunophenotypes of Hodgkin/Reed-Sternberg cells in classic Hodgkin's disease., Histopathology., 36,   2000年
  • A case of natural killer/T cell lymphoma of the subcutis resembling subcutaneous panniculitis-like T cell lymphoma., YAMASHITA Y, TSUZUKI T, NAKAYAMA A, FUJINO M, MORI N, Pathol Int., 49, (3) 241 - 246,   1999年
  • Hodgkin disease with subsequent transformation to CD30 positive non-hodgkin lymphoma in six patients., MORI N, WATANABE K, YAMASHITA Y, NAKAYAMA A, YATABE Y, NARITA M, KOBAYASHI T, HASEGAWA Y, NAGASAWA T, Cancer., 85, (4) 970 - 979,   1999年
  • Perforin and granzyme expression in cytotoxic T-cell lymphomas., Mod Pathol., 11,   1998年
  • Bronchiolitis obliterans in a patient with chronic graft-versus-host disease after bone marrow transplantation, 松本 浩平, 山内 辰也, 市川 元司, 益田 雄一郎, 小川 清隆, 荒井 孝, 伊藤 雅文, 山下 依子, Nihon Kyobu Shikkan Gakkai Zasshi., 34, (3) 345 - 349,   1996年
  • Primary cardiac lymphoma. No evidence for an etiologic association with Epstein-Barr virus., Arch Pathol Lab Med., 120, (6) 555 - 9,   1996年
  • Idiopathic adulthood ductopenia., J Gastroenterol Hepatol., 11, (4) 411 - 5,   1996年

書籍等出版物

  • ロビンス基礎病理学第8版 第19章 女性生殖器, エルゼビア・ジャパン社,   2011年

作品

  • マイクロアレイ法を用いた骨髄に初発するびまん性大細胞性B細胞性リンパ腫の発現解析,   2008年

競争的資金

  • 酸化ストレス発癌のメカニズムの解明,   2008年 - 2010年


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