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中西 良一ナカニシ リョウイチ

所属部署医学研究科腫瘍・免疫外科学分野
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Last Updated :2020/05/26

研究者基本情報

学歴

  •  - 1985年, 産業医科大学, 医学部

学位

  • 博士(医学), 産業医科大学

所属学協会

  • 日本呼吸器学会
  • 肺がんCT検診学会
  • 日本癌治療学会
  • 日本気管食道科学会
  • 日本肺癌学会
  • 日本内視鏡外科学会
  • 日本呼吸器内視鏡学会
  • 日本呼吸器外科学会
  • 日本胸部外科学会
  • 日本外科学会

委員歴

  • 日本呼吸器外科学会 施設認定委員会委員(1999-2005)
  • 日本呼吸器外科学会 選挙管理委員会委員(2009-2011)
  • 日本呼吸器外科学会 雑誌編集員会委員(2002-2013)
  • 日本呼吸器外科学会 手術教育部会部員(2015- )
  • 日本呼吸器外科学会 評議員資格審査委員会委員(2015- )

経歴

  • 産業医科大学医学部(第2外科学)助手(1992-1995)
  • 産業医科大学医学部(第2外科学)学内講師(1995-1997)
  • 産業医科大学医学部(第2外科学)講師(1997-2001)
  • 産業医科大学医学部(第2外科学)非常勤講師(2001-2015)
  • 名古屋市立大学大学院医学研究科 腫瘍・免疫外科学 教授 (2015- )

研究活動情報

研究キーワード

    胸腔鏡手術、肺癌

論文

  • Awake thoracoscopic surgery under epidural anesthesia: is it really safe?, Ryoichi Nakanishi, Manabu Yasuda, CHINESE JOURNAL OF CANCER RESEARCH, 26, (4) 368 - 370,   2014年08月
  • Thoracoscopic Anatomic Pulmonary Resection for Locally Advanced Non-Small Cell Lung Cancer, Ryoichi Nakanishi, Yoshihisa Fujino, Toshihiro Yamashita, Shinji Shinohara, Tsunehiro Oyama, ANNALS OF THORACIC SURGERY, 97, (3) 980 - 986,   2014年03月, Background. The safety and feasibility of thoracoscopic lobectomy for locally advanced lung cancer remain controversial. Methods. Between April 2002 and April 2011, we retrospectively reviewed 100 consecutive patients who underwent anatomic pulmonary resection for preoperative stage II or greater non-small cell lung cancer at a single institution. After excluding 16 patients undergoing planned thoracotomy and 8 patients with preoperative stage IV disease, the remaining 76 patients who underwent thoracoscopic surgery were divided chronologically into three groups and analyzed. Results. Thoracoscopic anatomic pulmonary resection was successfully performed in 74 patients (97.4%). There were 32 complications in 27 patients (35.5%), and 2 patients (2.6%) had grade 3 or higher complications. The operative, perioperative (30-day), and hospital mortality were 0%, 0%, and 2.6%, respectively. A significantly decreased operation time, a lower amount of blood loss, and increased numbers of bronchoplasty and bronchial coverage were seen, although there were no significant differences in the patient characteristics or other outcomes among the three groups. At a mean follow-up time of 40 months, the overall 3-year survival rates for pathologic stages I (n = 12), II (n = 27), III (n = 33), and IV (n = 4) were 100%, 64.2%, 36.2%, and 25.0%, respectively. Conclusions. Thoracoscopic anatomic pulmonary resection is feasible, with acceptable morbidity and mortality rates, as well as favorable oncologic outcomes, in selected patients with locally advanced non-small cell lung cancer. The learning curve for this procedure appears to be overcome after 25 consecutive patients. (C) 2014 by The Society of Thoracic Surgeons
  • Innovative techniques for thoracoscopic lobectomy in postpneumonectomy patients, Ryoichi Nakanishi, Shinji Shinohara, Kenji Muranaka, Koichi Shinohara, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 146, (3) 724 - 725,   2013年09月
  • Thoracoscopic carinal resection and reconstruction in a patient with mucoepidermoid carcinoma., Nakanishi Ryoichi, Yamashita Toshihiro, Muranaka Kenji, Shinohara Koichi, The Journal of thoracic and cardiovascular surgery, 145, (4) 1134 - 5,   2013年
  • Video-assisted thoracoscopic lobectomy for clinical stage I non-small cell lung cancer: experience with 111 consecutive patients demonstrating comorbidity, R. Nakanishi, M. Nakagawa, H. Tokufuchi, T. Okumura, M. Maeda, S. Kuboi, M. Kido, MINERVA CHIRURGICA, 67, (1) 67 - 75,   2012年02月, Aim. The outcomes of video-assisted thoracoscopic lobectomy for clinical stage I non-small cell lung cancer (NSCLC) patients with comorbidities were examined to determine the technical feasibility and safety of this procedure. Methods. Between January 2002 and December 2007, 111 consecutive patients with suspected stage I lung cancer, who individually had one or more comorbidities cited in the modified Kaplan-Feinstein Index, were scheduled for a video-assisted thoracoscopic lobectomy. The demographic, perioperative, and outcome variables were assessed. Results. One hundred of 111 patients had non-small cell lung cancer. Ninety-nine patients underwent successful video-assisted thoracoscopic lobectomies, while there was one conversion because of a hemorrhage from the pulmonary artery in the early stage. Including this one conversion, no patients required a blood transfusion during surgery or postoperatively. There were no intraoperative or in-hospital deaths. No complications occurred in 78 (78.8%) of 99 patients. Only one patient (1.0%) with a Kaplan-Feinstein Index Score of severe grade contracted pneumonia indicating grade 3 (severe), whereas the remaining 20 patients had grade 1 (mild) or 2 (moderate) complications. At a median follow-up of 40 months, the overall 3-year survival rates for postoperative stage IA (N.=52); IB (N.=26); and II or more (N.=21) were 100%; 78%; and 71%, respectively. Conclusion. A video-assisted thoracoscopic lobectomy is therefore considered to be a feasible and safe procedure for clinical stage I NSCLC even in patients with comorbidities.
  • Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism., Oyama Tsunehiro, Uramoto Hidetaka, Kagawa Norio, Yoshimatsu Takashi, Osaki Toshihiro, Nakanishi Ryoichi, Nagaya Hisao, Kaneko Kazuhiro, Muto Manabu, Kawamoto Toshihiro, Tanaka Fumihiro, Gotoh Akinobu, Frontiers in bioscience (Scholar edition), 4, 1539 - 46,   2012年
  • Perioperative Short-term Pulmonary Rehabilitation for Patients Undergoing Lung Volume Reduction Surgery, Masataka Irie, Ryoichi Nakanishi, Kazumi Hamada, Masamitsu Kido, COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 8, (6) 444 - 449,   2011年12月, Although pulmonary rehabilitation is recommended for patients undergoing lung volume reduction surgery, the optimal method of pulmonary rehabilitation is unclear. The aim of this study was to determine the feasibility and safety of perioperative short-term pulmonary rehabilitation. We enrolled candidates for lung volume reduction surgery from 1999 to 2006 and retrospectively evaluated the feasibility and safety of perioperative short-term pulmonary rehabilitation for these patients. The program included the progressive exercise training on a treadmill for approximately 3 weeks. Two primary endpoints, feasibility and safety, were determined by the adherence rates of the program session and the adverse events. Pulmonary function and exercise capacity were evaluated at baseline and the termination of pre- and postoperative short-term pulmonary rehabilitation. Twenty-two patients were enrolled in this study. All patients completed our program without any serious adverse events. The mean values of adherence rates of the preoperative, postoperative, and overall period were, 89.1%, 95.1%, and 92.1%, respectively. All values of pulmonary function tests, except for forced vital capacity, significantly improved at the termination of postoperative short-term pulmonary rehabilitation in comparison to those at the termination of preoperative short-term pulmonary rehabilitation. The values of the 6-minute walk distance, total exercise time, and maximal workload on incremental exercise test were significantly improved by preoperative short-term pulmonary rehabilitation, and their values were maintained until the termination of postoperative short-term pulmonary rehabilitation. The results indicated that it is both feasible and safe to perform perioperative short-term pulmonary rehabilitation.
  • Video-assisted thoracic surgery involving major pulmonary resection for central tumors, Ryoichi Nakanishi, Yoshihisa Fujino, Soichi Oka, Seiichi Odate, SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES, 24, (1) 161 - 169,   2010年01月, Background This pilot study aimed to examine the technical feasibility and safety of video-assisted thoracic surgery (VATS) involving major pulmonary resection for central tumors compared with the perioperative data obtained from historical cohorts who underwent open thoracotomy. Methods Between April 2002 and June 2008, 26 consecutive patients with centrally located lung tumors 6 cm in size or smaller with histologically confirmed or radiologically suspected non-small cell lung cancer were prospectively registered for VATS involving major pulmonary resection at a single institution. These patients were compared with 20 historical cohorts who underwent comparable surgical procedures by open thoracotomy in terms of demographic, perioperative, histopathologic, and outcome variables. Results One conversion was performed because of the patient's inability to tolerate single-lung ventilation, and this patient was excluded from this study. The two groups showed no differences in terms of demographic, operative, or histopathologic variables. Both groups presented with no mortality. The VATS group demonstrated a significantly lower C-reactive protein level (p = 0.0166), shorter chest tube drainage time (p = 0.0141), shorter epidural tube anesthesia (p < 0.0001), lower analgesic requirements (p = 0.0001), shorter hospital stay (p < 0.0001), and fewer postoperative complications (p = 0.0157) than the open thoracotomy group. Despite the short follow-up time, the two groups were comparable in terms of both recurrence and survival rates. Conclusions The results indicate that VATS involving major pulmonary resection is technically feasible and safe for selected patients with central lung tumors, with an acceptable perioperative outcome compared with open thoracotomy.
  • Video-Assisted Thoracic Surgery Lobectomy for Non-small Cell Lung Cancer in Patients with a Charlson Comorbidity Index Score of Two or More, Ryoichi Nakanishi, Toshihiro Yamashita, Soichi Oka, JOURNAL OF THORACIC ONCOLOGY, 5, (1) 56 - 61,   2010年01月, Introduction: We evaluated the feasibility and safety of the video-assisted thoracic surgery (VATS) lobectomy for non-small cell lung cancer (NSCLC) in patients with comorbidity. Methods: Between April 2000 and December 2006, a prospective database of 58 consecutive patients undergoing a VATS lobectomy for NSCLC, who had a Charlson comorbidity index score of 2 or more, was retrospectively analyzed. The demographic, perioperative, histopathologic, and outcome variables, including the recurrence and survival, were assessed. Results: The VATS lobectomy was successfully performed in 57 patients (16 women and 41 men; median age, 70 years). Twenty-three patients (40.4%) were aged 75 years or older. The total score of the Charlson comorbidity index was as follows: 2 in 26 patients, 3 in 13 patients, 4 in 12 patients, 5 in five patients, and 6 in one patient. None of the patients required a blood transfusion during surgery or during the postoperative course. We observed no intraoperative or in-hospital deaths, and no complications occurred in the 45 patients (78.9%). At a median follow-up of 34 months, a recurrence was observed in five patients who had advanced stages: a local recurrence in one and a distant recurrence in four. The overall 5-year survival rates for postoperative stage IA (n = 25) and IB (n 16) were 100% and 94%, respectively. Conclusions: We believe that a VATS lobectomy is a feasible and safe procedure for NSCLC in patients with comorbidity because this modality demonstrates an acceptable morbidity and a favorable oncologic outcome.
  • [Effects of smoking on video-assisted thoracic surgery lobectomy for lung cancer]., Nakanishi Ryoichi, Nakagawa Makoto, Tokufuchi Hiroshi, Okumura Takashi, Kuboi Satoshi, Kido Masamitsu, Journal of UOEH, 32, (1) 45 - 52,   2010年
  • Phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel in patients with completely resected non-small cell lung cancer., Sugaya Masakazu, Uramoto Hidetaka, Uchiyama Akihiko, Nagashima Akira, Nakanishi Ryoichi, Sakata Hisanobu, Nakanishi Kozo, Hanagiri Takeshi, Yasumoto Kosei, Anticancer research, 30, (7) 3039 - 44,   2010年
  • A randomized phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel versus carboplatin plus gemcitabine in patients with completely resected non-small cell lung cancer., Uramoto Hidetaka, Nakanishi Ryoichi, Nagashima Akira, Uchiyama Akihiko, Inoue Masaaki, Osaki Toshihiro, Yoshimatsu Takashi, Sakata Hisanobu, Nakanishi Kozo, Yasumoto Kosei, Anticancer research, 30, (11) 4695 - 9,   2010年
  • A prospective study of the association between drainage volume within 24 hours after thoracoscopic lobectomy and postoperative morbidity., Nakanishi Ryoichi, Fujino Yoshihisa, Yamashita Toshihiro, Oka Soichi, The Journal of thoracic and cardiovascular surgery, 137, (6) 1394 - 9,   2009年
  • Video-assisted thoracic surgery major pulmonary resection requiring control of the main pulmonary artery., Nakanishi Ryoichi, Oka Soichi, Odate Seiichi, Interactive cardiovascular and thoracic surgery, 9, (4) 618 - 22,   2009年
  • Cryopreservation of the tracheal grafts: Review and perspective., Nakanishi Ryoichi, Organogenesis, 5, (3) 113 - 8,   2009年
  • Video-assisted thoracic surgery superior segment-sparing lower lobectomy for intralobar pulmonary sequestration., Nakanishi Ryoichi, Iwanami Takashi, Journal of laparoendoscopic&advanced surgical techniques. Part A, 18, (2) 290 - 2,   2008年
  • Video-assisted thoracoscopic completion pneumonectomy for a second primary cancer: a case report., Nakanishi Ryoichi, Hirai Ayako, Yamashita Toshihiro, Oka Soichi, The Journal of thoracic and cardiovascular surgery, 135, (4) 945 - 6,   2008年
  • Metastatic pulmonary leiomyosarcoma presenting with a long disease-free interval: report of a case., Nishikawa Hitoshi, Nakanishi Ryoichi, Surgery today, 38, (7) 644 - 6,   2008年
  • Initial experience of video-assisted thoracic surgery lobectomy with partial removal of the pulmonary artery., Nakanishi Ryoichi, Yamashita Toshihiro, Oka Soichi, Interactive cardiovascular and thoracic surgery, 7, (6) 996 - 1000,   2008年
  • Revascularization of trachea in lung and tracheal transplantation, Ryoichi Nakanishi, CLINICAL TRANSPLANTATION, 21, (5) 668 - 674,   2007年09月, Ischemia is the primary risk factor for airway complications in double lung transplantation using tracheal anastomosis and in tracheal transplantation. Many treatment options as to revascularization for the trachea were herein described and reviewed. They include direct revascularization (using a conduit such as artery or vein), revascularization with tissue wrapping (using omentum, muscle, internal thoracic artery pedicle, pleura, or pericardial fat pad), and with drug administration (using corticosteroid hormone, prostaglandin, or angiogenic factor). As there are few organized reports including new information on revascularization for the trachea these days, this review article would help thoracic surgeons who get engaged transplantation.
  • [Pneumonectomy for lung cancer in a patient with acute respiratory failure; report of a case]., Nishikawa Hitoshi, Nakanishi R, Kyobu geka. The Japanese journal of thoracic surgery, 60, (3) 250 - 2,   2007年
  • Successful video-assisted thoracic surgery lobectomy in a single-lung patient., Nakanishi Ryoichi, Hirai Ayako, Muranaka Kenji, Shinohara Koichi, Surgical laparoscopy, endoscopy&percutaneous techniques, 17, (6) 562 - 4,   2007年
  • Solitary fibrous tumor of the pleura with hypoglycemia associated with serum insulin-like growth factor II., Hirai Ayako, Nakanishi Ryoichi, The Journal of thoracic and cardiovascular surgery, 132, (3) 713 - 4,   2006年
  • Multiglycosidorum tripterygii versus Tacrolimus for rat tracheal allografts, R Nakanishi, K Yasumoto, EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 28, (4) 588 - 593,   2005年10月, Objective: Several other immunosuppressive agents still need to be found for rejection as alternatives to Tacrolimus in lung transplantation. We tried to elucidate the treatment effect of Multiglycosidorum tripterygii on tracheal allografts in comparison to that of Tacrolimus. Methods: Treatment effect of agents on tracheal allografts, undergoing incomplete immunosuppression for 12 weeks after transplantation, was investigated using a heterotopic rat tracheal transplantation model. Treatments with Tacrolimus (1.0 or 1.5 mg/kg per day), Multiglycosidorum tripterygii (150 or 225 mg/kg per day) and a combination of Tacrolimus (1.0 mg/kg per day) and Multiglycosidorum tripterygii (150 mg/kg per day) were applied as a therapy for allografts. Four weeks after administering this therapy, the effect of each treatment was investigated by the morphologic assessment of transplants. Results: Treatment group with high doses of Multiglycosidorum tripterygii demonstrated a significantly better graft patency and lower cartilage dislocation than that without any treatment and tended to show better morphological findings than the other treatment groups, in addition to being safe. Some of allografts with high doses of Tacrolimus or Multiglycosidorum tripterygii therapy had a viable epithelium and viable tracheal glands in part, whereas the allografts with other treatments showed almost a completely denuded epithelium. High doses of Multiglycosidorum tripterygii therapy demonstrated less infiltration of mononuclear cells into the allografts, whereas other therapies showed a higher infiltration of such cells. Conclusions: We conclude that high doses of Multiglycosidorum tripterygii may be a useful alternative to Tacrolimus as an immunosuppressant for rat tracheal allografts. (c) 2005 Elsevier B.V. All rights reserved.
  • Lung volume reduction surgery for a professional athlete with Swyer-James syndrome, A Tasaki, R Nakanishi, ANNALS OF THORACIC SURGERY, 80, (1) 342 - 344,   2005年07月, Swyer-James syndrome is an uncommon, emphysematous disease characterized by roentgenographic hyperlucency of one lung or lobe due to loss of the pulmonary vascular structure and to alveolar overdistension. We here describe a 28-year-old professional bicycle racer with Swyer-James syndrome who had dyspnea on exertion, especially during a bicycle race. Lung volume reduction surgery was performed with video-assisted thoracoscopic surgery. This treatment improved his pulmonary function, and he is active as a bicycle racer now. (c) 2005 by The Society of Thoracic Surgeons.
  • Efficacy of multiglycosidorum tripterygii for rat tracheal allografts, R Nakanishi, K Yasumoto, JOURNAL OF HEART AND LUNG TRANSPLANTATION, 24, (3) 289 - 295,   2005年03月, Background: A new immunosuppressant must be developed because graft rejection remains the leading cause of death after lung transplantation. We evaluated the efficacy of Multiglycosidorum tripterygii as a new immunosuppressant using a heterotopic rat tracheal allotransplantation model. Methods: We performed short- and long-term experiments using a short-course of treatment with Multiglycosidorum tripterygii. To assess the immunosuppessive power of Multiglycosidorum tripterygii, we compared its efficacy (at 90, or 150 mg/kg/day) with that of tacrolimus (at 0.5, 1.0, or 1.5 mg/kg/day) at 4 weeks after transplantation. We then evaluated the effect of 150 mg/kg/day of Multiglycosidorum tripterygii treatment at 12 weeks after transplantation. Results: The efficacy of 150 mg/kg/day Multiglycosidorum tripterygii was superior to that of 90 mg/kg/day of the same drug and was comparable to that of 1.0 mg/kg/day tacrolimus, as demonstrated by morphologic assessment of the graft. Treatment with 150 mg/kg/day Multiglycosidorum tripterygii maintained graft morphology for 4 weeks but could not maintain graft viability for 12 weeks. Animals tolerated this dosage of Multiglycosidorum tripterygii for 12 weeks after administration. Conclusions: We conclude that the efficacy of Multiglycosidorum tripterygii is acceptable for rat tracheal allografts. Further studies are necessary to investigate Multiglycosidorum tripterygii treatment for clinical use in humans. Copyright (C) 2005 by the International Society for Heart and Lung Transplantation.
  • Malignant pleural mesothelioma with cavity formation in a 16-year-old boy., Nagata Shigenori, Nakanishi Ryoichi, Chest, 127, (2) 655 - 7,   2005年
  • Successful management of idiopathic fibrosing mediastinitis with superior vena cava thrombosis., Nakanishi R, Nishikawa H, The Journal of cardiovascular surgery, 46, (1) ,   2005年
  • [Diaphragm reconstruction after extrapleural pneumonectomy]., Nakanishi Ryoichi, Nishikawa H, Nagata S, Kyobu geka. The Japanese journal of thoracic surgery, 57, (11) 1050 - 3,   2004年
  • The immunomodulatory effect of cryopreservation in rat tracheal allotransplantation., Nakanishi Ryoichi, Onitsuka Takamitsu, Shigematsu Yoshiki, Hashimoto Mitsunori, Muranaka Hiroyuki, Yasumoto Kosei, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 21, (8) 890 - 8,   2002年
  • Feasibility of induction chemotherapy using bronchial arterial infusion for locally advanced non-small cell lung cancer: a pilot study., Osaki Toshihiro, Oyama Tsunehiro, Takenoyama Mitsuhiro, Taga Satoshi, So Tomoko, Yamashita Toshihiro, Nakata Shoji, Nakanishi Ryoichi, Yasumoto Kosei, Surgery today, 32, (9) 772 - 8,   2002年
  • Prediction of pulmonary complications after a lobectomy in patients with non-small cell lung cancer., Uramoto H, Nakanishi R, Fujino Y, Imoto H, Takenoyama M, Yoshimatsu T, Oyama T, Osaki T, Yasumoto K, Thorax, 56, (1) 59 - 61,   2001年
  • Feasibility of cryopreserved tracheal xenotransplants with the use of short-course immunosuppression., Hashimoto M, Nakanishi R, Umesue M, Muranaka H, Hachida M, Yasumoto K, The Journal of thoracic and cardiovascular surgery, 121, (2) 241 - 8,   2001年
  • Effect of cryopreservation period on rat tracheal allografts., Nakanishi R, Hashimoto M, Muranaka H, Yasumoto K, The Journal of heart and lung transplantation : the official publication of the International Society for HeartTransplantation, 20, (9) 1010 - 5,   2001年
  • Chronic expanding hematoma in the chest., Uramoto H, Nakanishi R, Eifuku R, Muranaka H, Takenoyama M, Yoshino I, Osaki T, Yasumoto K, The Journal of cardiovascular surgery, 41, (1) 143 - 6,   2000年
  • Short-course immunosuppression using FK506 for rat tracheal allografts., Hashimoto M, Nakanishi R, Muranaka H, Umesue M, Eifuku R, Yasumoto K, The Journal of cardiovascular surgery, 41, (3) 487 - 92,   2000年
  • Limit of warm ischemia time beforecryopreservation in rat tracheal isografts., Nakanishi R, Umesue M, Hashimoto M, Muranaka H, Hachida M, Yasumoto K, The Annals of thoracic surgery, 70, (6) 1880 - 4; discussion 1884-5,   2000年
  • Aggressive surgical treatment of multiple primary lung cancers., Uramoto H, Nakanishi R, Osaki T, Yoshino I, Yasumoto K, Scandinavian cardiovascular journal : SCJ, 34, (6) 603 - 5,   2000年
  • Respiratory compromise and dramatic chest X-ray changes during general anesthesia in a patient with a bronchogenic cyst., Sata T, Shiga Y, Nakanishi R, Yasumoto K, Shigematsu A, Anesthesiology, 90, (3) 911 - 3,   1999年
  • Bronchial arterial infusion is an effective therapeutic modality for centrally located early-stage lung cancer: results of a pilot study., Osaki T, Hanagiri T, Nakanishi R, Yoshino I, Taga S, Yasumoto K, Chest, 115, (5) 1424 - 8,   1999年
  • Maximal period of cryopreservation with the Bicell biofreezing vessel for rat tracheal isografts., Nakanishi R, Hashimoto M, Muranaka H, Umesue M, Kohno H, Yasumoto K, The Journal of thoracic and cardiovascular surgery, 117, (6) 1070 - 6,   1999年
  • Video-assisted thoracoscopic pericardiectomy for severe pericardial effusions., So T, Nakanishi R, Kohno H, Oe M, Yasumoto K, The Journal of cardiovascular surgery, 40, (2) 311 - 2,   1999年
  • Unfavorable prognosis of patients with stage II non-small cell lung cancer associated with macroscopic nodal metastases., Yoshino I, Nakanishi R, Osaki T, Takenoyama M, Taga S, Hanagiri T, Yasumoto K, Chest, 116, (1) 144 - 9,   1999年
  • Successful tracheocarinal transplantation., Nakanishi R, Hashimoto M, So T, Sugaya M, Yasumoto K, The Journal of cardiovascular surgery, 40, (4) 591 - 6,   1999年
  • Esophagopleural fistula originating from diverticulum after pneumonectomy. A case report and review of the literature., Inoue M, Nakanishi R, Osaki T, Yoshimatsu T, Yasumoto K, The Journal of cardiovascular surgery, 40, (5) 761 - 3,   1999年
  • Fas expression in non-small cell lung cancer: its prognostic effect in completely resected stage III patients., Uramoto H, Osaki T, Inoue M, Taga S, Takenoyama M, Hanagiri T, Yoshino I, Nakanishi R, Ichiyoshi Y, Yasumoto K, European journal of cancer (Oxford, England : 1990), 35, (10) 1462 - 5,   1999年
  • Improved airway healing using basic fibroblast growth factor in a canine tracheal autotransplantation model., Nakanishi R, Hashimoto M, Yasumoto K, Annals of surgery, 227, (3) 446 - 54,   1998年
  • Effects of interleukin-12 on the induction of cytotoxic T lymphocytes from the regional lymph node lymphocytes of patients with lung adenocarcinoma., Hanagiri T, Yoshino I, Takenoyama M, So T, Fujie H, Imabayashi S, Eifuku R, Yoshimatsu T, Osaki T, Nakanishi R, Ichiyoshi Y, Nagashima A, Nomoto K, Yasumoto K, Japanese journal of cancer research : Gann, 89, (2) 192 - 8,   1998年
  • p53 alteration, proliferating cell nuclear antigen, and nucleolar organizer regions in thymic epithelial tumors., Oyama T, Osaki T, Mitsudomi T, Ogawa R, Nakanishi R, Sugio K, Yasumoto K, International journal of molecular medicine, 1, (5) 823 - 6,   1998年
  • An endometrial nodule in the lung without pelvic endometriosis., Shimizu I, Nakanishi R, Yoshino I, Yasumoto K, The Journal of cardiovascular surgery, 39, (6) 867 - 8,   1998年
  • Optimal dose of basic fibroblast growth factor for long-segment orthotopic tracheal autografts, R Nakanishi, N Nagaya, T Yoshimatsu, T Hanagiri, K Yasumoto, JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 113, (1) 26 - 36,   1997年01月, When a primary anastomosis of the trachea is not feasible, extensive grafting is required. However, despite the use of omental wrapping for revascularization, long-segment tracheal grafts frequently do not maintain structural integrity because of insufficient blood supply. We examined the use of basic fibroblast growth factor for preservation of long-segment tracheal autografts after orthotopic transplantation with omental wrapping in 23 dogs. All animals received orthotopic tracheal transplantation, with 14-ring autografts that occupied a major part of the thoracic trachea, and omental wrapping. The 23 animals were classified randomly into six groups as follows: no treatment (group I, n = 3), topical administration of fibrin glue alone (group II, n = 4), fibrin glue enriched with 1 mu g/cm(2) basic fibroblast growth factor (group III, n = 4), fibrin glue enriched with 5 mu g/cm(2) basic fibroblast growth factor (group IV, n = 4), and fibrin glue enriched with 10 mu g/cm(2) basic fibroblast growth factor (groups V and VI, each n = 4). The omentum that was used to wrap the autografts was fed by the right gastroepiploic artery in groups I to V and by both the right gastroepiploic artery and splenic artery in group VI. All autografts in groups I and II showed dissolution. Ten of 12 autografts in groups III, V, and VI did not maintain long-term structural integrity. By contrast, all autografts in group IV showed long-term viability, as demonstrated by graft patency, epithelialization, cartilage morphology, and vascularity. We conclude that treatment with fibrin glue enriched with 5 mu g/cm(2) basic fibroblast growth factor in combination with omental wrapping may prolong the viability of long-segment tracheal autografts.
  • Combined carboplatin and cisplatin therapy in patients with advanced non-small cell lung cancer., Nakanishi R, Kume T, Mitsudomi T, Yoshimatsu T, Osaki T, Tokunaga H, Yasumoto K, American journal of clinical oncology, 20, (1) 31 - 5,   1997年
  • Prognostic value of the immunohistochemical detection of p16INK4 expression in nonsmall cell lung carcinoma., Taga S, Osaki T, Ohgami A, Imoto H, Yoshimatsu T, Yoshino I, Yano K, Nakanishi R, Ichiyoshi Y, Yasumoto K, Cancer, 80, (3) 389 - 95,   1997年
  • Treatment strategy for patients with surgically discovered N2 stage IIIA non-small cell lung cancer., Nakanishi R, Osaki T, Nakanishi K, Yoshino I, Yoshimatsu T, Watanabe H, Nakata H, Yasumoto K, The Annals of thoracic surgery, 64, (2) 342 - 8,   1997年
  • The induction of cytotoxic T lymphocytes against HLA-A locus-matched lung adenocarcinoma in patients with non-small cell lung cancer., Yoshino I, Takenoyama M, Fujie H, Hanagiri T, Yoshimatsu T, Imabayashi S, Eifuku R, Ogami A, Yano K, Osaki T, Nakanishi R, Ichiyoshi Y, Nomoto K, Yasumoto K, Japanese journal of cancer research : Gann, 88, (8) 743 - 9,   1997年
  • Postoperative prognosis in patients with non-small cell lung cancer with synchronous ipsilateral intrapulmonary metastasis., Yoshino I, Nakanishi R, Osaki T, Hasuda S, Taga S, Takenoyama M, Yoshimatsu T, Yasumoto K, The Annals of thoracic surgery, 64, (3) 809 - 13,   1997年
  • [Treatment with expandable metallic stent in patients with carcinomatous airway stenosis--evaluation of patient's quality of life]., Yoshimatsu T, Nakanishi R, Osaki T, Eifuku R, Ohgami A, Kodate M, Hanagiri T, Yoshino I, Nakanishi K, Yasumoto K, [Zasshi][Journal]. Nihon Kyōbu Geka Gakkai, 45, (11) 1787 - 91,   1997年
  • Postoperative complications after pneumonectomy for treatment of lung cancer: multivariate analysis., Mitsudomi T, Mizoue T, Yoshimatsu T, Oyama T, Nakanishi R, Okabayashi K, Osaki T, KumeT, Yasumoto K, Sugimachi K, Journal of surgical oncology, 61, (3) 218 - 22,   1996年
  • [A case report of a left bronchial stump fistula from which the wrapped omentum was removed, because of rupture of the anastomotic aneurysm of the descending thoracic aorta--functions of the wrapped omentum in the early phase and extended phase after surg, Ozaki S, Nakanishi R, Onimura S, Tokunaga H, Yasumoto K, [Zasshi][Journal]. Nihon Kyōbu Geka Gakkai, 44, (5) 687 - 90,   1996年
  • Increased levels of serum intercellular adhesion molecule-1 (ICAM-1) in patients with non-small cell lung cancer., Osaki T, Mitsudomi T, Yoshida Y, Oyama T, Ohgami A, Nakanishi K, Nakanishi R, Sugio K, Yasumoto K, Surgical oncology, 5, (3) 107 - 13,   1996年
  • Proliferating cell nuclear antigen may be superior to argyrophilic nucleolar organizer regions in predicting shortened survival of patients with non-small cell lung cancer., Oyama T, Mitsudomi T, Mizoue T, Ohgami A, Osaki T, Nakanishi R, Yasumoto K, Surgical oncology, 4, (2) 83 - 9,   1995年
  • p53 nuclear immunostaining and gene mutations in non-small-cell lung cancer and their effects on patient survival., Mitsudomi T, Oyama T, Nishida K, Ogami A, Osaki T, Nakanishi R, Sugio K, Yasumoto K, Sugimachi K, Annals of oncology : official journal of the European Society for Medical Oncology / ESMO, 6 Suppl 3, S9 - 13,   1995年
  • Successful management of tracheo-innominate artery fistula using interposition of a thymus pedicle flap., Nakanishi R, Shimazu A, Mitsudomi T, Masuda T, Osaki T, Onimura S, Shigematsu A, Sata T, Urano H, Yasumoto K, The Journal of laryngology and otology, 109, (2) 161 - 2,   1995年
  • Short-course immunosuppression after tracheal allotransplantation in dogs., Nakanishi R, Yasumoto K, Shirakusa T, The Journal of thoracic and cardiovascular surgery, 109, (5) 910 - 7,   1995年
  • Serum level and tissue expression of c-erbB-2 protein in lung adenocarcinoma., Osaki T, Mitsudomi T, Oyama T, Nakanishi R, Yasumoto K, Chest, 108, (1) 157 - 62,   1995年
  • Experimental carinal autotransplantation and allotransplantation., Takachi T, Shirakusa T, Shiraishi T, Okabayashi K, Inutsuka K, Kawahara K, Nakanishi R, The Journal of thoracic and cardiovascular surgery, 110, (3) 762 - 7,   1995年
  • [A case of postoperative hyponatremia caused by Sheehan syndrome associated with lung carcinoma]., Ozaki S, Nakanishi R, Sakata K, Mitsudomi T, Yasumoto K, Journal of UOEH, 17, (3) 199 - 205,   1995年
  • Minimal dose of cyclosporin A for tracheal allografts., Nakanishi R, Yasumoto K, The Annals of thoracic surgery, 60, (3) 635 - 9,   1995年
  • Surgical treatment of lung cancer in the octogenarian., Osaki T, Shirakusa T, Kodate M, Nakanishi R, Mitsudomi T, Ueda H, The Annals of thoracic surgery, 57, (1) 188 - 92; discussion 192-3,   1994年
  • Surgical resection for pulmonary metastases of sweat gland carcinoma., Osaki T, Kodate M, Nakanishi R, Mitsudomi T, Shirakusa T, Thorax, 49, (2) 181 - 2,   1994年
  • Omentopexy for tracheal autografts., Nakanishi R, Shirakusa T, Takachi T, The Annals of thoracic surgery, 57, (4) 841 - 5,   1994年
  • Combined thoracoscopy and mediastinoscopy for theevaluation of mediastinal lymph node metastasis in left upper lobe lung cancer., Nakanishi R, Mitsudomi T, Osaki T, The Journal of cardiovascular surgery, 35, (4) 347 - 9,   1994年
  • Early histopathologic features of tracheal allotransplant rejection: a study in nonimmunosuppressed dogs., Nakanishi R, Shirakusa T, Hanagiri T, Transplantation proceedings, 26, (6) 3715 - 8,   1994年
  • Papillary carcinoma in a huge intrathoracic goiter with tracheal stenosis and invasion. Case report., Hanagiri T, Hatooka S, Oosaki T, Nakanishi R, Mitsudomi T, Shirakusa T, Scandinavian journal of thoracic and cardiovascular surgery, 27, (3-4) 165 - 8,   1993年
  • [Serum levels of c-erbB-2 protein in patients with lung adenocarcinoma: preliminary report]., Ohsaki T, Mitsudomi T, Oyama T, Kodate M, Nakanishi R, Shirakusa T, Nihon Geka Gakkai zasshi, 94, (3) ,   1993年
  • Maximum length of tracheal autografts in dogs., Nakanishi R, Shirakusa T, Mitsudomi T, The Journal of thoracic and cardiovascular surgery, 106, (6) 1081 - 7,   1993年
  • Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer., Mitsudomi T, Oyama T, Kusano T, Osaki T, Nakanishi R, Shirakusa T, Journal of the National Cancer Institute, 85, (24) 2018 - 23,   1993年
  • [Tracheal reconstruction of extensive circumferential defects using cadaveric tracheal allograft: preliminary report]., Nakanishi R, Shirakusa T, Nihon Geka Gakkai zasshi, 93, (6) ,   1992年
  • [An assessment of the separation of mediastinal lymph nodes by preoperative mediastinoscopic examination as a dissecting measure in the surgical treatment of lung cancer]., Nakanishi R, Shirakusa T, Hirao D, Yasugawa H, Noda Y, Tokunaga H, Takada T, [Zasshi][Journal]. Nihon Kyōbu Geka Gakkai, 40, (9) 1707 - 13,   1992年
  • [Tracheal reconstruction in 29 canines using allograft--a surgical technique]., Nakanishi R, Shirakusa T, Journal of UOEH, 13, (1) 47 - 51,   1991年
  • [Result of surgical treatment in 226 cases of primary lung cancer]., Nakanishi R, Shirakusa T, Hirao D, Takada C, Tokunaga H, Journal of UOEH, 13, (2) 95 - 101,   1991年
  • [Primary multiple neurilemmoma of the diaphragm]., Nakanishi R, Shirakusa T, Miyazaki K, Hirota N, [Zasshi][Journal]. Nihon Kyōbu Geka Gakkai, 39, (11) 2041 - 5,   1991年
  • [A fatal rheumatoid pneumonitis following surgery for lung cancer]., Nakanishi R, Shirakusa T, Higashi T, Journal of UOEH, 13, (4) 319 - 24,   1991年
  • [The use of the aortic bypass in the surgery of the esophageal carcinoma invading the thoracic aorta]., Kawahara H, Odagiri S, Nakanishi K, Watanabe H, Nakanishi R, Ishikawa H, Ishikura Y, Yoshimatsu H, Rinshō kyōbu geka = Japanese annals of thoracic surgery, 9, (6) 551 - 6,   1989年
  • Combined thoracoscopy and mediastinoscopy for mediastinal lymph node staging of lung cancer., Nakanishi R, Yasumoto K, International surgery, 81, (4) 359 - 61
  • Proliferating cell nuclear antigen and argyrophilic nucleolar organizer regions in patients with thymic disease., Oyama T, Osaki T, Mitsudomi T, Mizoue T, Ohgami A, Nakanishi R, Sugio K, Yasumoto K, Oncology reports, 4, (6) 1201 - 5
  • Rejection of discordant skin xenografts by CD4- CD8- TCR alpha beta+ cells in CD4- and CD8-deficient mice., Umesue M, Mayumi H, Kong Y Y, Omoto K, Muranaka H, Nakanishi R, Kohno H, Yasumoto K, Kishihara K, Nomoto K, Transplantation proceedings, 31, (1-2) 890 - 1
  • Pleural retraction and intra-tumoral air-bronchogram as prognostic factors for stage I pulmonary adenocarcinoma following complete resection., Yoshino I, Nakanishi R, Kodate M, Osaki T, Hanagiri T, Takenoyama M, Yamashita T, Imoto H, Taga S, Yasumoto K, International surgery, 85, (2) 105 - 12

受賞

  •   2011年, 第3回福岡県医学会総会奨励賞
  •   1995年, 第45回手術手技研究会研究奨励賞, 気道系吻合部創傷治癒に対するbFGFの効果について報告.

競争的資金

  • 同種気管及び分岐部気管移植片による実験的気道再建, 産業医科大学, 広範囲の気管及び気管分岐部切除に対し、同種移植による再建の可能性と限界について検討した。1.雑種成犬20頭を対象に、同種移植片の拒絶反応に関する組織学的検討を行った。非免疫抑制犬では上皮・気管腺の修復が認められず、軟骨の障害も徐々に高度となり、間質では線維化を伴った肉芽増生が認められた。拒絶反応に特異的な単核球早期には認められなかった。経時的な組織障害度を自家移植片と比較したところ、移植後早期の拒絶反応の診断として上皮の修復障害がきわめて有用な組織学的所見の一つであった。2.雑種成犬6頭を対象に、あらかじめ4cm以下に設定した自家移植片により再建できる気管欠損範囲の限界を検討した。移植片にかかる張力が1kgを越える16ringの欠損部の再建は困難であったが、犬胸腔内気管の全長にあたる14ringでは、移植片に0.7kgしか張力がかからず、良好な生着を示した。次に、雑種成犬6頭を対象として、移植片にかかる張力を軽減する目的で、宿主
  • 凍結保存同種気管移植に関する研究, 産業医科大学, 本研究では,1)長期凍結保存の気管移植片への影響に関する検討,2)凍結保存時間別の移植片免疫反応に関する検討,そして3)免疫抑制剤の短期間投与による臨床的免疫寛容の導入に関する検討を行った。1) Lewisラットによる腹腔大網内への異所性同系移植モデルを用いて,0,1,2週間,1,2,3,6,9,12ヶ月の凍結保存移植片のviabilityを評価した結果,凍結保存時間の延長につれて上皮・軟骨共に変性が認められ,特に9ヶ月以上の凍結保存では解凍直後よりも移植後にさらに変性が強く認められた。移植期間を3ヶ月に延ばして創傷治癒を長期間観察した結果,凍結保存6ヶ月以上では形態が増悪したのに比べ,3ヶ月以下の凍結保存では移植期間延長により組織は可逆的に回復した。以上より,凍結保存の限界は3ヶ月と考えられた。2) 腹腔大網内への異所性同種気管移植(Lewis rat×BN rat)モデルを用いて検討した結果,凍結保存による変化を認めるものの,それによる免疫反応への影響は認められなかった。そのため,凍結保

社会貢献活動情報

社会貢献活動

  • 第3回北九州食道癌研究会, 北九州食道癌研究会,   2015年05月23日 - 2015年05月23日, 肺癌に対する内視鏡手術 ー これまでの足跡 ー
  • 呼吸器治療勉強会, 呼吸器治療勉強会,   2015年03月26日 - 2015年03月26日, 肺癌に対する 内視鏡手術 ー限界への挑戦ー
  • 第65回遠賀・八幡勉強会, 萩原中央病院,   2014年11月27日 - 2014年11月27日, COPD・肺癌に対する 胸腔鏡手術 ー限界への挑戦ー
  • 第59回北九州循環器懇談会, 北九州循環器懇談会,   2014年11月14日 - 2014年11月14日, COPD・肺癌に対する 先進的内視鏡手術
  • 呼吸器外科手術手技を語る会2014, 産業医科大学,   2014年09月12日 - 2014年09月12日, 肺癌に対する胸腔鏡手術 ー基本的手技から適応拡大までー
  • 小倉北区病薬連携フォーラム, 薬剤師会,   2014年08月28日 - 2014年08月28日, タバコ、COPDそして肺癌 ー世界初の内視鏡手術を中心にー
  • 第3回鹿児島呼吸器外科フォーラム, 鹿児島大学呼吸器外科,   2014年07月22日 - 2014年07月22日, 肺癌に対する胸腔鏡手術 ーその限界への挑戦ー
  • 飯塚病院特別講演会, 飯塚病院,   2014年02月21日 - 2014年02月21日, 完全胸腔鏡手術を極める
  • 市民公開講座, 新小倉病院,   2013年09月07日 - 2013年09月07日, 肺がんに対する画期的な外科治療
  • 小倉南区呼吸器疾患勉強会, 医師会,   2013年08月27日 - 2013年08月27日, 肺癌におけるX線診断と革新的な外科治療
  • 京都・行橋医師会呼吸器疾患連携勉強会, 京都・行橋医師会,   2013年08月08日 - 2013年08月08日, COPDと肺癌に対する革新的な外科治療 ー常に患者QOLをめざしてー
  • 戸畑区医師会学術講演会, 戸畑医師会,   2012年07月24日 - 2012年07月24日, COPDと肺がんに対する内視鏡手術 ー肺がんのX線診断も含めてー
  • 豊前築上医師会学術講演会, 豊前築上医師会,   2012年01月20日 - 2012年01月20日, 肺癌とCOPDに対する内視鏡手術 ー肺癌のX線診断も含めてー
  • 門司外科医会, 外科医師会,   2011年05月10日 - 2011年05月10日, COPD・肺癌に対する外科的治療戦略
  • 第63回日本胸部外科学会総会 教育セミナー post-graduate course, 日本胸部外科学会九州地方会,   2010年10月24日 - 2010年10月24日, 食道癌手術における気道処理の手技
  • 市民公開講座, 新小倉病院,   2010年06月19日 - 2010年06月19日, 肺がんの内視鏡手術
  • 小倉内科医会実地医家シリーズ講演会, 内科医師会,   2009年07月14日 - 2009年07月14日, 肺癌のX線診断と外科治療 〜胸腔鏡手術の適応と今後の展望〜
  • 第14回洞薬会がん薬物療法研修会, 薬剤師会,   2008年11月26日 - 2008年11月26日, 肺癌の臨床と外科治療の展望
  • 小倉ロータリークラブ会員卓話, 小倉ロータリークラブ,   2008年10月31日 - 2008年10月31日, たばこと肺がん 〜痛みの少ない内視鏡手術〜
  • 第57回共済医学会 教育講演, 共済医学会,   2008年10月07日 - 2008年10月08日, 肺癌に対する内視鏡手術の現況
  • 北九州看護研修会, 看護協会,   2007年02月23日 - 2007年02月23日, たばこと肺がん 〜早期発見と痛みの少ない治療〜 version 2
  • 市民公開講座, 新小倉病院,   2006年10月21日 - 2006年10月21日, たばこと肺がん 〜早期発見と痛みの少ない治療〜
  • 第39回日本胸部外科学会九州地方会 教育講演, 日本胸部外科学会九州地方会,   2006年07月27日 - 2006年07月27日, VATS lobectomy 〜障害因子とその克服法〜について教育講演
  • 門司税関健康講話, 門司税関,   2004年03月11日 - 2004年03月11日, 肺癌の怖さ、知ってますか? 〜肺癌の早期発見と早期治療〜 part 2
  • ムーブ健康講話, 新小倉病院,   2002年04月23日 - 2002年04月23日, 肺癌の怖さ、知ってますか? 〜肺癌の早期発見と早期治療〜


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