村島　美穂 (ムラシマ　ミホ)

研究者情報

学位

• 博士（医学）（2017年11月 奈良県立医科大学）

J-Global ID

• 202001020844596518

研究分野

• その他 / その他

経歴

• 2024年04月  近畿大学医学部腎臓内科講師

研究活動情報

論文

• Epidemiology and predictors of hyponatremia in a contemporary cohort of patients with malignancy: a retrospective cohort study

  Miho Murashima; Kaori Ambe; Yuka Aoki; Takahisa Kasugai; Tatsuya Tomonari; Minamo Ono; Masashi Mizuno; Masahiro Tohkin; Takayuki Hamano

  Clinical Kidney Journal sfad189  2023年08月
• The use of anti-adrenergic agents as a predictor of acute kidney injury and delayed recovery of kidney function: the NARA-AKI cohort study.

  Masatoshi Nishimoto; Miho Murashima; Maiko Kokubu; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Yasuhiro Akai; Kazuhiko Tsuruya

  Hypertension research : official journal of the Japanese Society of Hypertension 2023年06月
• The cisplatin-induced acute kidney injury is a novel risk factor for postoperative complications in patients with esophageal cancer: a retrospective cohort study.

  Shuhei Ueno; Miho Murashima; Ryo Ogawa; Masaki Saito; Sunao Ito; Shunsuke Hayakawa; Tomotaka Okubo; Hiroyuki Sagawa; Tatsuya Tanaka; Hiroki Takahashi; Yoichi Matsuo; Akira Mitsui; Masahiro Kimura; Takayuki Hamano; Shuji Takiguchi

  BMC surgery 23 1 67 - 67 2023年03月
• Kidney function at 3 months after acute kidney injury is an unreliable indicator of subsequent kidney dysfunction: the NARA-AKI Cohort Study.

  Masatoshi Nishimoto; Miho Murashima; Maiko Kokubu; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Yasuhiro Akai; Kazuhiko Tsuruya

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 38 3 664 - 670 2023年02月
• Comparable outcomes between a combination of peritoneal dialysis with once-weekly hemodialysis and thrice-weekly hemodialysis: a prospective cohort study.

  Miho Murashima; Takayuki Hamano; Masanori Abe; Ikuto Masakane

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2023年01月
• Performance Status Modifies the Association Between Vitamin D Receptor Activator and Mortality or Fracture: A Prospective Cohort Study on the Japanese Society for Dialysis Therapy (JSDT) Renal Data Registry.

  Miho Murashima; Takayuki Hamano; Takeshi Nishiyama; Kazuhiko Tsuruya; Satoshi Ogata; Eiichiro Kanda; Masanori Abe; Ikuto Masakane; Kosaku Nitta

  Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 37 8 1489 - 1499 2022年06月
• Anti-neoplastic agents associated with abrupt decline in kidney function(和訳中)

  Murashima Miho; Kasugai Takahisa; Tomonari Tatsuya; Ono Minamo; Mizuno Masashi; Hamano Takayuki

  日本腎臓学会誌 64 3 246 - 246 2022年05月
• Total kidney volume as an independent predictor of anemia recovery after cardiac surgery(和訳中)

  Tomonari Tatsuya; Murashima Miho; Kasugai Takahisa; Mizuno Masashi; Ono Minamo; Hamano Takayuki

  日本腎臓学会誌 64 3 275 - 275 2022年05月
• Total kidney volume as a predictor for non-atherosclerotic cardiovascular disease(CVD) in patients with diabetic kidney disease(DKD)(和訳中)

  Mizuno Masashi; Murashima Miho; Kasugai Takahisa; Tomonari Tatsuya; Ono Minamo; Hamano Takayuki

  日本腎臓学会誌 64 3 287 - 287 2022年05月
• Sodium-glucose cotransporter 2 inhibitors and anemia among diabetes patients in real clinical practice.

  Miho Murashima; Tomohiro Tanaka; Takahisa Kasugai; Tatsuya Tomonari; Atsuki Ide; Minamo Ono; Masashi Mizuno; Taisei Suzuki; Takayuki Hamano

  Journal of diabetes investigation 2021年11月
• External Validation of a Prediction Model for Acute Kidney Injury Following Noncardiac Surgery.

  Masatoshi Nishimoto; Miho Murashima; Maiko Kokubu; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Yasuhiro Akai; Kazuhiko Tsuruya

  JAMA network open 4 10 e2127362  2021年10月
• Combination of once-weekly haemodialysis with peritoneal dialysis is associated with lower mortality compared with peritoneal dialysis alone: a longitudinal study.

  Miho Murashima; Takayuki Hamano; Masanori Abe; Ikuto Masakane

  Clinical kidney journal 14 6 1610 - 1617 2021年06月
• Impact of self-reported walking habit on slower decline in renal function among the general population in a longitudinal study: the Japan Specific Health Checkups (J-SHC) Study.

  Masatoshi Nishimoto; Miho Murashima; Hisako Yoshida; Masahiro Eriguchi; Hikari Tasaki; Fumihiro Fukata; Takaaki Kosugi; Masaru Matsui; Ken-Ichi Samejima; Kunitoshi Iseki; Koichi Asahi; Kunihiro Yamagata; Shouichi Fujimoto; Tsuneo Konta; Ichiei Narita; Toshiki Moriyama; Masato Kasahara; Yugo Shibagaki; Masahide Kondo; Tsuyoshi Watanabe; Kazuhiko Tsuruya

  Journal of nephrology 34 6 1845 - 1853 2021年04月
• Anemia following acute kidney injury after noncardiac surgery and long-term outcomes: the NARA-AKI cohort study.

  Masatoshi Nishimoto; Miho Murashima; Maiko Kokubu; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Yasuhiro Akai; Kazuhiko Tsuruya

  Clinical kidney journal 14 2 673 - 680 2021年02月
• Encapsulating Peritoneal Sclerosis and Mortality Related to Infection in Patients on Combination Once-Weekly Hemodialysis with Peritoneal Dialysis.

  Miho Murashima; Takayuki Hamano; Masanori Abe; Ikuto Masakane

  American journal of nephrology 52 4 336 - 341 2021年
• Positive association between intra-operative fluid balance and post-operative acute kidney injury in non-cardiac surgery: the NARA-AKI cohort study.

  Masatoshi Nishimoto; Miho Murashima; Maiko Kokubu; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Yasuhiro Akai; Kazuhiko Tsuruya

  Journal of nephrology 33 3 561 - 568 2020年06月 [査読有り]
  
• Pre-operative proteinuria and post-operative acute kidney injury in noncardiac surgery: the NARA-Acute Kidney Injury cohort study.

  Masatoshi Nishimoto; Miho Murashima; Maiko Kokubu; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Yasuhiro Akai; Kazuhiko Tsuruya

  Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 35 12 2111 - 2116 2019年12月 [査読有り]
  
• Inflammation as a predictor of acute kidney injury and mediator of higher mortality after acute kidney injury in non-cardiac surgery.

  Miho Murashima; Masatoshi Nishimoto; Maiko Kokubu; Takayuki Hamano; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Yasuhiro Akai; Kazuhiko Tsuruya

  Scientific reports 9 1 20260 - 20260 2019年12月 [査読有り]
  
• Acute kidney injury as an independent predictor of infection and malignancy: the NARA-AKI cohort study.

  Miho Tagawa; Masatoshi Nishimoto; Maiko Kokubu; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Yasuhiro Akai; Kazuhiko Tsuruya

  Journal of nephrology 32 6 967 - 975 2019年12月 [査読有り]
  
• A Prediction Model with Lifestyle in Addition to Previously Known Risk Factors Improves Its Predictive Ability for Cardiovascular Death.

  Masatoshi Nishimoto; Miho Tagawa; Masaru Matsui; Masahiro Eriguchi; Ken-Ichi Samejima; Kunitoshi Iseki; Chiho Iseki; Koichi Asahi; Kunihiro Yamagata; Tsuneo Konta; Shouichi Fujimoto; Ichiei Narita; Masato Kasahara; Yugo Shibagaki; Toshiki Moriyama; Masahide Kondo; Tsuyoshi Watanabe; Kazuhiko Tsuruya

  Scientific reports 9 1 12953 - 12953 2019年09月 [査読有り]
  
• Author Correction: Higher dialysate calcium concentration is associated with incident myocardial infarction among diabetic patients with low bone turnover: a longitudinal study.

  Miho Tagawa; Takayuki Hamano; Shinichi Sueta; Satoshi Ogata; Yoshihiko Saito

  Scientific reports 8 1 13217 - 13217 2018年08月 [査読有り]
  
• Higher dialysate calcium concentration is associated with incident myocardial infarction among diabetic patients with low bone turnover: a longitudinal study.

  Miho Tagawa; Takayuki Hamano; Shinichi Sueta; Satoshi Ogata; Yoshihiko Saito

  Scientific reports 8 1 10060 - 10060 2018年07月 [査読有り]
  
• Acute kidney injury in a postpartum woman with paroxysmal nocturnal hemoglobinuria: A case report and literature review.

  Masatoshi Nishimoto; Masaru Matsui; Hideo Tsushima; Kaori Tanabe; Miho Tagawa; Ken-Ich Samejima; Yasuhiro Akai; Yoshihiko Saito

  Hemodialysis international. International Symposium on Home Hemodialysis 22 1 E6-E10  2018年01月 [査読有り]
  
• Prognostic Value of Predialysis Indices for Technique Failure and Mortality in Peritoneal Dialysis Patients.

  Masaru Matsui; Yasuhiro Akai; Ken-Ichi Samejima; Hideo Tsushima; Kaori Tanabe; Katsuhiko Morimoto; Miho Tagawa; Yoshihiko Saito

  Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy 21 5 493 - 499 2017年10月 [査読有り]
  
• Acute pulmonary thromboembolism occurring during treatment with tolvaptan in a patient with autosomal-dominant polycystic kidney disease.

  Katsuhiko Morimoto; Yasuhiro Akai; Masaru Matsui; Hiroki Yano; Miho Tagawa; Ken-Ichi Samejima; Yoshihiko Saito

  CEN case reports 6 1 61 - 65 2017年05月 [査読有り]
  
• Angiogenic Factors and Risks of Technique Failure and Cardiovascular Events in Patients Receiving Peritoneal Dialysis.

  Masaru Matsui; Ken-Ichi Samejima; Yukiji Takeda; Katsuhiko Morimoto; Miho Tagawa; Kenji Onoue; Satoshi Okayama; Hiroyuki Kawata; Rika Kawakami; Yasuhiro Akai; Hiroyuki Okura; Yoshihiko Saito

  Cardiorenal medicine 6 3 251 - 9 2016年05月 [査読有り]
  
• Pre- and/or Intra-Operative Prescription of Diuretics, but Not Renin-Angiotensin-System Inhibitors, Is Significantly Associated with Acute Kidney Injury after Non-Cardiac Surgery: A Retrospective Cohort Study.

  Miho Tagawa; Ai Ogata; Takayuki Hamano

  PloS one 10 7 e0132507  2015年 [査読有り]
  
• Prognostic Impact of Placental Growth Factor on Mortality and Cardiovascular Events in Dialysis Patients.

  Masaru Matsui; Ken-ichi Samejima; Yukiji Takeda; Kaoru Tanabe; Katsuhiko Morimoto; Keisuke Okamoto; Miho Tagawa; Kenji Onoue; Satoshi Okayama; Hiroyuki Kawata; Rika Kawakami; Yasuhiro Akai; Yoshihiko Saito

  American journal of nephrology 42 2 117 - 25 2015年 [査読有り]
  
• [A case report of hepatitis B virus reactivation in a hepatitis B core antibody-positive, hepatitis B surface antigen-negative hemodialysis patient].

  Makiko Kondo; Shinichi Sueta; Emi Oida; Miho Tagawa

  Nihon Jinzo Gakkai shi 57 8 1363 - 8 2015年 [査読有り]
  
• Membranous nephropathy associated with type 1 autoimmune pancreatitis and dominant glomerular IgG4 deposit.

  Shinichi Sueta; Makiko Kondo; Takeshi Matsubara; Yumiko Yasuhara; Shinichi Akiyama; Enyu Imai; Hisashi Amaike; Miho Tagawa

  CEN case reports 3 1 18 - 23 2014年05月 [査読有り]
  
• Mineral Metabolism Markers Are Associated with Myocardial Infarction and Hemorrhagic Stroke but Not Ischemic Stroke in Hemodialysis Patients: A Longitudinal Study.

  Miho Tagawa; Takayuki Hamano; Hiroshi Nishi; Kenji Tsuchida; Norio Hanafusa; Atsushi Fukatsu; Kunitoshi Iseki; Yoshiharu Tsubakihara

  PloS one 9 12 e114678  2014年 [査読有り]
  
• Effect of darbepoetin alfa on endothelial progenitor cells and vascular reactivity in chronic kidney disease.

  Emile R Mohler 3rd; Lifeng Zhang; Elizabeth Medenilla; Wade Rogers; Benjamin French; Andrew Bantly; Jonni S Moore; Yonghong Huan; Miho Murashima; Jeffrey S Berns

  Vascular medicine (London, England) 16 3 183 - 9 2011年06月 [査読有り]
  
• [IV. Others: 4. Human immunodeficiency virus associated renal dysfunction].

  Miho Tagawa

  Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 100 5 1319 - 23 2011年05月 [査読有り]
  
• [Case of lead nephropathy due to chronic occupational lead exposure].

  Ai Ogata; Shinichi Sueta; Miho Tagawa

  Nihon Jinzo Gakkai shi 53 2 207 - 11 2011年 [査読有り]
  
• Comparison of intradialytic blood pressure variability between conventional thrice-weekly hemodialysis and short daily hemodialysis.

  Miho Murashima; Dinesh Kumar; Alden M Doyle; Joel D Glickman

  Hemodialysis international. International Symposium on Home Hemodialysis 14 3 270 - 7 2010年07月 [査読有り]
  
• Adrenal venous sampling for primary aldosteronism and clinical outcomes after unilateral adrenalectomy: a single-center experience.

  Miho Murashima; Scott O Trerotola; Douglas L Fraker; Dale Han; Raymond R Townsend; Debbie L Cohen

  Journal of clinical hypertension (Greenwich, Conn.) 11 6 316 - 23 2009年06月 [査読有り]
  
• Methotrexate clearance by high-flux hemodialysis and peritoneal dialysis: a case report.

  Miho Murashima; Jill Adamski; Michael C Milone; Leslie Shaw; Donald E Tsai; Roy D Bloom

  American journal of kidney diseases : the official journal of the National Kidney Foundation 53 5 871 - 4 2009年05月 [査読有り]
  
• The pitfalls of a purely clinical definition of nephrogenic systemic fibrosis: comment on the article by Todd et al.

  Camille E Introcaso; Steven M Brunelli; Joel M Gelfand; Anuj S Malik; Miho Murashima; Irfan Ahmed; Harold I Feldman; David J Margolis

  Arthritis and rheumatism 58 5 1552; author reply 1552-4  2008年05月 [査読有り]
  
• Chronic tubulointerstitial nephritis presenting as multiple renal nodules and pancreatic insufficiency.

  Miho Murashima; John Tomaszewski; Joel D Glickman

  American journal of kidney diseases : the official journal of the National Kidney Foundation 49 1 e7-10  2007年01月 [査読有り]
  

共同研究・競争的資金等の研究課題

• 尿細管に着目した腫瘍腎臓病学

  日本学術振興会：科学研究費助成事業

  研究期間 : 2021年04月 -2024年03月 

  代表者 : 濱野 高行; 村島 美穂; 安部 賀央里

   

  当院で2018年から2020年までの間に抗癌剤治療を受けた2644名の後方視的観察研究を行った。eGFRが前回のeGFRに比して30％以上低下するものをAKIと定義して、AKIに関連する抗がん剤をまずは見だした。平均年齢は65歳で平均eGFR は71 (59-84) mL/min/1.73m2であった。Pembrolizumab, trastuzumabと oxaliplatinがAKIと関連し、そのオッズ比(95%信頼区間)はそれぞれ 1.52 [1.03-2.23], 2.78 [1.26-6.12],1.72 [1.20-2.46]であった。 抗癌剤以外のリスク因子は高いCRPとループ利尿薬やトルバプタン、抗血小板薬の使用であった。PembrolizumabやtrastuzumabとAKIの関連はNSAIDs使用患者で特に強かった。 抗腫瘍薬による電解質異常を早期に捕捉できるようにするため、2021年5月から当院で電子カルテ上で自動的に各科主治医に腎臓内科受診を促す「電解質バスターズ」なるシステムを構築した。実際に依頼を行うかどうかは担当医師の判断にゆだねた。紹介基準はNa<125, Na>160, K<2.5, K>6.0, 補正Ca<7.5, 補正Ca>11.5, Mg<1.0, Mg>4.0 mEq/Lとした。電解質バスターズ導入前後6か月の依頼箋数を比較したところ、K異常は導入前後で紹介数は変わらなかったが、Na, Ca, Mg異常は各々2倍に増え、３つの電解質異常をまとめると依頼のincident rate ratioは2.01（95% CI: 1.00-4.24）となった。依頼の最も多い低Na血症16例のうち、5例がSIADH、5例が薬剤性（抗癌剤や利尿剤）を含む腎性Na喪失、3例が水中毒と診断され、SIADHの２例にトルバプタンを導入しNa濃度が改善した。
• 急性腎障害後の予後予測因子に関する前向き研究

  日本学術振興会：科学研究費助成事業

  研究期間 : 2020年04月 -2024年03月 

  代表者 : 村島 美穂

   

  本研究では、急性腎障害を起こした患者を前向きに長期経過観察を行い、一般的な心血管系イベントや末期腎不全のリスク因子（血圧、蛋白尿、脂質、血糖、喫煙など）だけではなく、炎症、貧血、骨代謝などについても、予後との関連を検討し、今後の介入研究につなげていくことを目的とする。対象患者は慢性腎臓病(推定糸球体ろ過量(eGFR)が60ml/min/1.73m2未満が3か月以上持続)、尿蛋白陽性：尿定性検査における尿蛋白が(2+)あるいはそれ以上の患者で、心臓血管外科で心臓手術あるいは大血管手術を受ける患者、または消化器外科で、全身麻酔下に腹腔内手術を受ける患者、または悪性腫瘍に対する化学療法を受ける患者である。主要評価項目は全死亡、心血管系イベント（侵襲的処置を必要とする狭心症、閉塞性動脈硬化症、心筋梗塞、脳梗塞、脳出血、入院を要する心不全） 、入院を要する感染症、悪性腫瘍の再発及び新規診断、骨折、functional status、腎機能、透析導入の有無、QOL(SF-36の点数)である。関係各科（心臓血管外科、消化器外科、臨床腫瘍部）の了承を得て、当該年度において、Institutional Review Boardの承認を得て、患者の登録を開始した。現在、２５例を登録している。上記の評価項目に加えて、CTで計測される腎容積と急性腎障害の関連、急性腎障害の予後と腎容積の関連も今後、解析していく予定としている。

その他のリンク

researchmap

https://researchmap.jp/nagoyacu