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植田 典浩ウエダ ノリヒロ

所属部署医学研究科医学・医療教育学分野
職名講師
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Last Updated :2020/04/04

研究者基本情報

所属学協会

  • 日本不整脈心電学会
  • 日本循環器学会
  • 日本内科学会
  • 日本医学教育学会

研究活動情報

論文

  • Association of left atrial phasic volumes with systemic arterial stiffness and ankle-brachial index in hypertensive patients, M. Iida, M. Yamamoto, Y. Ishiguro, M. Yamazaki, N. Ueda, H. Honjo, K. Kamiya, JOURNAL OF HUMAN HYPERTENSION, 31, (4) 270 - 277,   2017年04月, 査読有り, Left atrial (LA) phasic volumes consist of reservoir, conduit and booster pump volumes. Arterial stiffness is linked to lower systemic arterial compliance (SAC) contributing to cardiac afterload. Arterial stiffness may be a modulator of LA phasic volumes. Echocardiography was performed in 161 hypertensive patients and in 50 normotensive subjects in order to assess biplane LA volumes (maximum, before atrial contraction, minimum), early and late diastolic mitral annular velocity (e' and a'), and LV stroke volume. LA emptying volumes (total, passive, active) were calculated from these LA volumes. Blood pressures were measured using an automated oscillometric device simultaneously at the four limbs for evaluating pulse pressure (PP) and ankle- brachial index (ABI). SAC was estimated by the ratio of LV stroke volume indexed by body surface area (BSA) divided by PP. All three LA volumes, LA total volume and LA active emptying volume were greater in hypertensive patients than in normotensive subjects. A multiple linear regression analysis indicated that LA passive emptying volume (reservoir = early diastole)/BSA correlated positively with ABI after being adjusted for age, gender, BSA, LV mass, max LA volume, e' and SAC in hypertensive patients. LA active emptying volume (booster = late diastole)/BSA correlated positively with SAC after being adjusted for age, gender, BSA, LV mass, LA volume before atrial contraction, a' and ABI. LA reservoir volume was associated with ABI, and LA booster volume was related to systemic arterial stiffness in hypertensive patients, suggesting the LA-arterial coupling in this clinical setting.
  • The role of gap junctions in stretch-induced atrial fibrillation, Norihiro Ueda, Mitsuru Yamamoto, Haruo Honjo, Itsuo Kodama, Kaichiro Kamiya, CARDIOVASCULAR RESEARCH, 104, (2) 364 - 370,   2014年11月, 査読有り, The aim of this study was to investigate the role of gap junctions in atrial fibrillation (AF) by analysing the effects of a gap junction enhancer and blocker on AF vulnerability and electrophysiological properties of isolated hearts. The acute atrial stretch model of AF in the isolated rabbit heart was used. Sustained AF (SAF) was induced by a burst of high-frequency stimulation of the Bachmann's bundle. The effective refractory period (ERP) was measured, and the total conduction time (TCT) and the pattern of conduction of the anterior surface of the left atrium were monitored by using an optical mapping system. The effect of enhancing gap junction function by 100-1000 nM rotigaptide (ZP123) and block by 30 mu M carbenoxolone on these parameters was measured. SAF inducibility was increased with an elevation of intra-atrial pressure. Enhanced gap junction conductance induced by treatment with 100-1000 nM rotigaptide reduced SAF inducibility, and the gap junction blocker carbenoxolone increased SAF inducibility. In the absence of gap junction enhancer or blocker, normal conduction was observed at 0 cmH(2)O. When intra-atrial pressure was raised to 12 cmH(2)O, the conduction pattern was changed to a heterogeneous zig-zag pattern and TCT was prolonged. Conduction pattern was not affected by either agent. Rotigaptide shortened TCT, whereas carbenoxolone prolonged TCT. ERP was significantly shortened with an increase in intra-atrial pressure, but ERP was unaffected by either agent. Gap junction modulators changed AF inducibility through their effects on atrial conduction, not by altering ERP.
  • Urinary type IV collagen is related to left ventricular diastolic function and brain natriuretic peptide in hypertensive patients with prediabetes, Masato Iida, Mitsuru Yamamoto, Yuko S. Ishiguro, Masatoshi Yamazaki, Norihiro Ueda, Haruci Honjo, Kaichirou Kamiya, JOURNAL OF DIABETES AND ITS COMPLICATIONS, 28, (6) 824 - 830,   2014年11月, 査読有り, Aim: Urinary type IV collagen is an early biomarker of diabetic nephropathy. Concomitant prediabetes (the early stage of diabetes) was associated with left ventricular (LV) diastolic dysfunction and increased brain natriuretic peptide (BNP) in hypertensive patients. We hypothesized that urinary type IV collagen may be related to these cardiac dysfunctions. Methods: We studied hypertensive patients with early prediabetes (HbA1c <5.7% and fasting glucose >110, n = 18), those with prediabetes (HbA1c 5.7-6.4, n = 98), and those with diabetes (HbA1c > 6.5 or on diabetes medications, n = 92). The participants underwent echocardiography to assess left atrial volume/body surface area (BSA) and the ratio of early mitral flow velocity to mitral annular velocity (E/e'). Left ventricular diastolic dysfunction (LVDD) was defined if patients had E/e' >= 15, or E/e' = 9-14 accompanied by left atrial volume/BSA >= 32 ml/mm(2). Urinary samples were collected for type IV collagen and albumin, and blood samples were taken for BNP and HbA1c. Results: Urinary type IV collagen and albumin increased in parallel with the deterioration of glycemic status. In hypertensive patients with prediabetes, subjects with LVDD had higher levels of BNP and urinary type IV collagen than those without LVDD. In contrast, in hypertensive patients with diabetes, subjects with LVDD had higher urinary albumin and BNP than those without LVDD. Urinary type IV collagen correlated positively with BNP in hypertensive patients with prediabetes, whereas it correlated with HbA1c in those with diabetes. Conclusions: In hypertensive patients with prediabetes, urinary type IV collagen was associated with LV diastolic dysfunction and BNP. (C) 2014 Elsevier Inc. All rights reserved.
  • Utility of cystatin C as a marker for the severity of aortic regurgitation in hypertensive patients, Iida Masato, Yamamoto Mitsuru, Ishiguro Yuko S, Yamazaki Masatoshi, Ueda Norihiro, Honjo Haruo, Kamiya Kaichirou, CLINICA CHIMICA ACTA, 425, 259 - 264,   2013年10月21日, 査読有り
  • Atrial selectivity in Na+ channel blockade by acute amiodarone, Suzuki Tomoyuki, Morishima Mikio, Kato Sara, Ueda Norihiro, Honjo Haruo, Kamiya Kaichiro, CARDIOVASCULAR RESEARCH, 98, (1) 136 - 144,   2013年04月01日, 査読有り
  • Detection of QT prolongation through approximation of the T wave on Gaussian mixture modeling., Hibino S, Ueda N, Horiba M, Yasui K, Kagamihara Y, Funahashi S, Kamiya K, Honda H, Circulation journal : official journal of the Japanese Circulation Society, 77, (11) 2728 - 2735,   2013年, 査読有り
  • Inhibition of intercellular coupling stabilizes spiral-wave reentry, whereas enhancement of the coupling destabilizes the reentry in favor of early termination, Takemoto Yoshio, Takanari Hiroki, Honjo Haruo, Ueda Norihiro, Harada Masahide, Kato Sara, Yamazaki Masatoshi, Sakuma Ichiro, Opthof Tobias, Kodama Itsuo, Kamiya Kaichiro, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 303, (5) H578 - H586,   2012年09月, 査読有り
  • Midkine gene transfer after myocardial infarction in rats prevents remodelling and ameliorates cardiac dysfunction, Sumida Arihiro, Horiba Mitsuru, Ishiguro Hisaaki, Takenaka Hiroharu, Ueda Norihiro, Ooboshi Hiroaki, Opthof Tobias, Kadomatsu Kenji, Kodama Itsuo, CARDIOVASCULAR RESEARCH, 86, (1) 113 - 121,   2010年04月01日, 査読有り
  • T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers, Horiba Mitsuru, Muto Takao, Ueda Norihiro, Opthof Tobias, Miwa Keiko, Hojo Mayurni, Lee Jong-Kook, Kamiya Kaichiro, Kodama Itsuo, Yasui Kenji, LIFE SCIENCES, 82, (11-12) 554 - 560,   2008年03月12日, 査読有り
  • Aldosterone modulates I-f current through gene expression in cultured neonatal rat ventricular myocytes, Muto Takao, Ueda Norihiro, Opthof Tobias, Ohkusa Tomoko, Nagata Kohzo, Suzuki Shinsuke, Tsuji Yukiomi, Horiba Mitsuru, Lee Jong-Kook, Honjo Haruo, Kamiya Kaichiro, Kodama Itsuo, Yasui Kenji, AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 293, (5) H2710 - H2718,   2007年11月, 査読有り
  • Effects of ultrasound energy application on cardiac performance in open-chest guinea pigs - An in vivo pilot study, Kuma Furniaki, Ueda Norihiro, Ito Hiroyuki, Maruyama Toru, Kaji Yoshikazu, Fujino Takehiko, Harada Mine, CIRCULATION JOURNAL, 70, (10) 1356 - 1361,   2006年10月, 査読有り
  • Pathophysiological basis for monitoring of whole heart conductance by 2-lead system., Yasuda Y, Maruyama T, Nakamura H, Arita T, Ueda N, Harada M, Circulation journal : official journal of the Japanese Circulation Society, 70, (4) 495 - 501,   2006年04月, 査読有り
  • Coronary occlusion and reperfusion promote early afterdepolarizations and ventricular tachycardia in a canine tissue model of type 3 long QT syndrome., Ueda N, Zipes DP, Wu J, American journal of physiology. Heart and circulatory physiology, 290, (2) H607 - 12,   2006年02月, 査読有り
  • A unipolar coronary sinus mapping study of patients with left-sided atrioventricular accessory pathways., Kubota S, Nakasuga K, Maruyama T, Ueda N, Ito H, Kaji Y, Harada M, International heart journal, 46, (4) 657 - 667,   2005年07月, 査読有り
  • Epicardial but not endocardial premature stimulation initiates ventricular tachyarrhythmia in canine in vitro model of long QT syndrome., Ueda N, Zipes DP, Wu J, Heart rhythm, 1, (6) 684 - 694,   2004年12月, 査読有り
  • Functional and transmural modulation of M cell behavior in canine ventricular wall., Ueda N, Zipes DP, Wu J, American journal of physiology. Heart and circulatory physiology, 287, (6) H2569 - 75,   2004年12月, 査読有り
  • Prior ischemia enhances arrhythmogenicity in isolated canine ventricular wedge model of long QT 3., Ueda N, Zipes DP, Wu J, Cardiovascular research, 63, (1) 69 - 76,   2004年07月, 査読有り
  • Reentrant atrial tachycardia originating from the superior vena cava., Okamoto K, Ito H, Kuma F, Koike A, Shimoike E, Ueda N, Maruyama T, Kaji Y, Fujino T, Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 8, (3) 203 - 208,   2003年06月, 査読有り
  • Subthreshold stimulation in three types of reentrant supraventricular tachycardia: correlation with the results of catheter ablation., Ueda N, Kaji Y, Maruyama T, Shimoike E, Ito H, Fujino T, Niho Y, Harada M, Japanese circulation journal, 65, (12) 1057 - 1063,   2001年12月, 査読有り
  • Entrapment of a guide wire by the Chiari network in a patient with ablated idiopathic ventricular tachycardia., Shimoike E, Ueda N, Maruyama T, Kaji Y, Niho Y, Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing, 5, (2) 219 - 222,   2001年06月, 査読有り
  • Influence of right atrial structure on outcome of radio-frequency catheter ablation for common atrial flutter., Ohba Y, Shimoike E, Ueda N, Maruyama T, Kaji Y, Fujino T, Niho Y, Japanese circulation journal, 64, (10) 741 - 744,   2000年10月, 査読有り
  • In vivo and in vitro study of radio-frequency application with a new long linear probe: implication for the maze operation., Shimoike E, Kaji Y, Ueda N, Maruyama T, Kanaya S, Niho Y, The Journal of thoracic and cardiovascular surgery, 120, (1) 164 - 172,   2000年07月, 査読有り
  • Radiofrequency catheter ablation of upper septal idiopathic left ventricular tachycardia exhibiting left bundle branch block morphology., Shimoike E, Ueda N, Maruyama T, Kaji Y, Journal of cardiovascular electrophysiology, 11, (2) 203 - 207,   2000年02月, 査読有り
  • Heart rate variability analysis of patients with idiopathic left ventricular outflow tract tachycardia: role of triggered activity., Shimoike E, Ueda N, Maruyama T, Kaji Y, Kanaya S, Fujino T, Niho Y, Japanese circulation journal, 63, (8) 629 - 635,   1999年08月, 査読有り
  • Radiofrequency catheter ablation of left ventricular outflow tract tachycardia from the coronary cusp: a new approach to the tachycardia focus., Shimoike E, Ohnishi Y, Ueda N, Maruyama T, Kaji Y, Journal of cardiovascular electrophysiology, 10, (7) 1005 - 1009,   1999年07月, 査読有り
  • Radiofrequency catheter ablation of idiopathic right ventricular tachycardia near the His bundle., Shimoike E, Ohba Y, Yanagi N, Ohtsuka S, Ohnishi Y, Ueda N, Nozaki M, Maruyama T, Kaji Y, Takahashi N, Niho Y, Fukuoka igaku zasshi = Hukuoka acta medica, 90, (4) 132 - 139,   1999年04月, 査読有り
  • Experimental ablation study using a new long linear probe in isolated porcine hearts., Shimoike E, Ueda N, Maruyama T, Kaji Y, Kanaya S, Fujino T, Niho Y, Japanese heart journal, 40, (2) 189 - 197,   1999年03月, 査読有り
  • Na+-K+ pump inhibition caused by chronic amiodarone in guinea pig myocardium., Maruyama T, Ueda N, Kaji Y, Kanaya S, Fujino T, Niho Y, Heart and vessels, 14, (5) 216 - 223,   1999年, 査読有り
  • Radiofrequency catheter ablation of left ventricular outflow tract tachycardia: report of two cases., Shimoike E, Ohba Y, Yanagi N, Hiramatsu SI, Ueda N, Maruyama T, Kaji Y, Kanaya S, Fujino T, Niho Y, Journal of cardiovascular electrophysiology, 9, (2) 196 - 202,   1998年02月, 査読有り


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