Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Date (from‐to) : 2012/04 -2016/03
Author : Higuchi Shigekazu; KITAMURA SHINGO; HIDA AKIKO; TSUJIMURA SEI-ICHI
In our previous study, we found that a single nucleotide polymorphism of I394T (rs1079610) in the melanopsin gene was associated with pupillary light response in human. Since melanopsin has a characteristic spectral sensitivity to light, in this study, we aimed to determine associations among I394T genotypes and physiological responses under diverse light wavelengths. In the results, the CC+CT subjects showed greater percentage of pupillary constriction than the TT subjects under light conditions that strongly excites melanopsin (high-intensity and short wavelength). In addition, there was a difference in spectral sensitivity between the genotype groups; the TC subjects and TT subjects showed peak responsiveness at 476 nm light and 480 nm light, respectively. In the comparison of habitual sleep between the genotype groups, sleep/wake timing of CC subjects was significantly later than the TT or TC subjects.