ITO Keima

Researcher Information

Degree

• PhD（2024/03 Nagoya City University）

Research funding number

• 51000921

ORCID ID

•  https://orcid.org/0000-0002-9217-6956

J-Global ID

• 202301018427950659

Research Interests

• Asthma   Chronic cough   Functional gastrointestinal disorders   

Research Areas

• Life sciences / Respiratory medicine

Education

• 2019/04 - 2024/03  Nagoya City University Graduate School  医学研究科  博士課程
• 2009/04 - 2015/03  Nagoya City University  医学部  医学科

Association Memberships

• 日本咳嗽学会   日本喘息学会   日本アレルギー学会   日本呼吸器内視鏡学会   日本呼吸器学会   日本内科学会   

Published Papers

• Risk Factors for Liver Injury and Their Association with Treatment in Hospitalized Patients with COVID-19.

  Chihiro Kato; Yutaka Ito; Yuta Mori; Keima Ito; Kensuke Fukumitsu; Satoshi Fukuda; Yoshihiro Kanemitsu; Takehiro Uemura; Tomoko Tajiri; Hirotsugu Ohkubo; Tetsuya Oguri; Atsushi Nakamura; Akio Niimi

  Internal medicine (Tokyo, Japan) 2025/03
• Staphylococcus aureus enterotoxin sensitization is associated with declined capsaicin cough sensitivity in chronic obstructive pulmonary disease.

  Yoshihiro Kanemitsu; Kensuke Fukumitsu; Ryota Kurokawa; Taisuke Akamatsu; Satoshi Fukuda; Yutaka Ito; Yuki Amakusa; Tatsuro Suzuki; Keima Ito; Yuta Mori; Takehiro Uemura; Tomoko Tajiri; Hirotsugu Ohkubo; Toshihiro Shirai; Akio Niimi

  Scientific reports 14 (1) 29613 - 29613 2024/11
• Productive cough associated with patient-reported outcomes and computed tomography analysis results in idiopathic pulmonary fibrosis: a single centre cross-sectional study.

  Kohei Fujita; Yoshihiro Kanemitsu; Hirotsugu Ohkubo; Akihito Okada; Akiko Nakano; Keima Ito; Yuta Mori; Kensuke Fukumitsu; Satoshi Fukuda; Takehiro Uemura; Tomoko Tajiri; Yutaka Ito; Tetsuya Oguri; Yoshiyuki Ozawa; Takayuki Murase; Akio Niimi

  ERJ open research 10 (5) 2024/09
• Usefulness of serum transthyretin for prediction of the 1-year outcome in idiopathic pulmonary fibrosis: An evaluation of sarcopenic and nutritional indicators.

  Kohei Fujita; Akihito Okada; Hirotsugu Ohkubo; Akiko Nakano; Keima Ito; Yuta Mori; Kensuke Fukumitsu; Satoshi Fukuda; Yoshihiro Kanemitsu; Takehiro Uemura; Tomoko Tajiri; Yutaka Ito; Tetsuya Oguri; Yoshiyuki Ozawa; Takayuki Murase; Akio Niimi

  Respiratory investigation 62 (5) 889 - 896 2024/08
• Prevalence and clinical relevance of comorbid pertussis infection in adult patients with asthma: A prospective, cross-sectional study.

  Hirono Nishiyama; Tomoko Tajiri; Ryota Kurokawa; Tatsuro Suzuki; Keima Ito; Yuta Mori; Kensuke Fukumitsu; Satoshi Fukuda; Yoshihiro Kanemitsu; Takehiro Uemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Akio Niimi

  Respiratory investigation 62 (5) 811 - 816 2024/07
• Efficacy of dupilumab for severe chronic rhinosinusitis with nasal polyps and asthma: A prospective study.

  Tomoko Tajiri; Motohiko Suzuki; Hirono Nishiyama; Yoshiyuki Ozawa; Ryota Kurokawa; Keima Ito; Kensuke Fukumitsu; Yuta Mori; Yoshihiro Kanemitsu; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Shinichi Iwasaki; Akio Niimi

  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2024/07
• Comorbid functional dyspepsia reflects IL-33-mediated airway neuronal dysfunction in asthma.

  Keima Ito; Yoshihiro Kanemitsu; Takashi Ueda; Takeshi Kamiya; Eiji Kubota; Yuta Mori; Kensuke Fukumitsu; Tomoko Tajiri; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Yutaka Ito; Yasuhiro Shibata; Natsuko Kumamoto; Shinya Ugawa; Akio Niimi

  The Journal of allergy and clinical immunology 2024/06
• Efficacy of dupilumab for airway hypersecretion and airway wall thickening in patients with moderate-to-severe asthma: A prospective, observational study

  Tomoko Tajiri; Motohiko Suzuki; Hirono Nishiyama; Yoshiyuki Ozawa; Ryota Kurokawa; Norihisa Takeda; Keima Ito; Kensuke Fukumitsu; Yoshihiro Kanemitsu; Yuta Mori; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Kenji Izuhara; Akio Niimi

  Allergology International Elsevier BV 1323-8930 2024/03
• Low Daily Step Count Associated with Small Erector Spine Muscle Area and Sarcopenia in Idiopathic Pulmonary Fibrosis.

  Hirotsugu Ohkubo; Kohei Fujita; Keima Ito; Akiko Nakano; Minoru Horiuchi; Yuta Mori; Kensuke Fukumitsu; Satoshi Fukuda; Yoshihiro Kanemitsu; Takehiro Uemura; Tomoko Tajiri; Yutaka Ito; Yoshiyuki Ozawa; Takayuki Murase; Akio Niimi

  Internal medicine (Tokyo, Japan) 2023/10
• Bronchial thermoplasty improves cough hypersensitivity and cough in severe asthmatics.

  Hirono Nishiyama; Yoshihiro Kanemitsu; Johsuke Hara; Kensuke Fukumitsu; Norihisa Takeda; Ryota Kurokawa; Keima Ito; Tomoko Tajiri; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Akio Niimi

  Respiratory medicine 216 107303 - 107303 2023/09
• Targeting the interleukin-5 pathway improves cough hypersensitivity in patients with severe uncontrolled asthma

  Keima Ito; Yoshihiro Kanemitsu; Kensuke Fukumitsu; Tomoko Tajiri; Hirono Nishiyama; Yuta Mori; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Akio Niimi

  Annals of Allergy, Asthma & Immunology Elsevier BV 131 (2) 203 - 208.e1 1081-1206 2023/08
• Tiotropium for refractory cough in asthma via cough reflex sensitivity: A randomized, parallel, open-label trial

  Kensuke Fukumitsu; Yoshihiro Kanemitsu; Ryota Kurokawa; Norihisa Takeda; Tomoko Tajiri; Hirono Nishiyama; Keima Ito; Yoshitsugu Inoue; Sayaka Yamamoto; Yuta Mori; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Akio Niimi

  Annals of Allergy, Asthma & Immunology Elsevier BV 131 (1) 59 - 68.e3 1081-1206 2023/07
• Functional gastrointestinal disorders are associated with capsaicin cough sensitivity in severe asthma

  Keima Ito; Yoshihiro Kanemitsu; Takeshi Kamiya; Kensuke Fukumitsu; Norihisa Takeda; Tomoko Tajiri; Ryota Kurokawa; Hirono Nishiyama; Jennifer Yap; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Akio Niimi

  Allergology International Elsevier BV 72 (2) 271 - 278 1323-8930 2023/04
• Decreased capsaicin cough reflex sensitivity predicts hospitalisation due to COPD.

  Yoshihiro Kanemitsu; Ryota Kurokawa; Taisuke Akamatsu; Kensuke Fukumitsu; Satoshi Fukuda; Yutaka Ito; Norihisa Takeda; Hirono Nishiyama; Keima Ito; Tomoko Tajiri; Yuta Mori; Takehiro Uemura; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Tetsuya Oguri; Toshihiro Shirai; Akio Niimi

  BMJ open respiratory research 10 (1) 2023/01
• Specific IgE Response and Omalizumab Responsiveness in Severe Allergic Asthma.

  Tomoko Tajiri; Motohiko Suzuki; Takeo Kutsuna; Hirono Nishiyama; Keima Ito; Norihisa Takeda; Kensuke Fukumitsu; Yoshihiro Kanemitsu; Satoshi Fukuda; Takehiro Umemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Kosho Yoshikawa; Akio Niimi

  Journal of asthma and allergy 16 149 - 157 2023
• Residual Dyspnea May Predict Small Airways Dysfunction and Poor Responsiveness to Single-Inhaler Triple Therapy in Asthmatic Patients

  Keima Ito; Tomoko Tajiri; Hirono Nishiyama; Ryota Kurokawa; Jenifer Maries Go Yap; Norihisa Takeda; Kensuke Fukumitsu; Yoshihiro Kanemitsu; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Akio Niimi

  Journal of Asthma and Allergy 2022/11
• Characteristics of the European Thoracic Society/American Thoracic Society severe asthma definition as a determinant of future use of biologics/bronchial thermoplasty.

  Hirono Nishiyama; Yoshihiro Kanemitsu; Kensuke Fukumitsu; Norihisa Takeda; Ryota Kurokawa; Tomoko Tajiri; Keima Ito; Jenifer Maries Go Yap; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Akio Niimi

  Asia Pacific allergy 12 (2) e13  2022/04
• Reflux-related symptoms reflect poor asthma control and the presence of airway neuronal dysfunction.

  Ryota Kurokawa; Yoshihiro Kanemitsu; Kensuke Fukumitsu; Norihisa Takeda; Tomoko Tajiri; Hirono Nishiyama; Jennifer Maries Yap; Keima Ito; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Masaya Takemura; Akio Niimi

  Allergology international : official journal of the Japanese Society of Allergology 71 (3) 318 - 324 2022/01
• Pretreatment Alveolar Nitric Oxide Levels Predict Improvement of Pulmonary Function 1 Year Following Anti-Asthma Treatments in Patients with Inhaled Corticosteroid-Naïve Asthma.

  Kensuke Fukumitsu; Hirono Nishiyama; Yoshihiro Kanemitsu; Norihisa Takeda; Ryota Kurokawa; Tomoko Tajiri; Keima Ito; Jenifer Maries Go Yap; Sayaka Yamamoto; Yoshitsugu Inoue; Satoshi Fukuda; Takehiro Uemura; Osamu Takakuwa; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Motohiko Suzuki; Masaya Takemura; Akio Niimi

  International archives of allergy and immunology 183 (5) 479 - 489 2022
• COVID‐19 pneumonia suspected to be co‐infection with Mycoplasma pneumoniae and improved by early administration of favipiravir and ciclesonide

  Keima Ito; Takako Yokoyama; Minoru Horiuchi; Munehiro Kato; Ikuji Usami

  Respirology Case Reports 2021/09
• The impact of budesonide inhalation suspension for asthma hospitalization: In terms of length of stay, recovery time from symptoms, and hospitalization costs

  Keima Ito; Yoshihiro Kanemitsu; Kensuke Fukumitsu; Yoshitsugu Inoue; Hirono Nishiyama; Sayaka Yamamoto; Yuki Kitamura; Ryota Kurokawa; Norihisa Takeda; Satoshi Fukuda; Takehiro Uemura; Tomoko Tajiri; Osamu Takakuwa; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Akio Niimi

  Allergology International Elsevier BV 69 (4) 571 - 577 1323-8930 2020/10
• A case of non-small cell lung cancer with long-term response after re-challenge with nivolumab

  Keima Ito; Tetsuya Oguri; Norihisa Takeda; Kensuke Fukumitsu; Satoshi Fukuda; Yoshihiro Kanemitsu; Tomoko Tajiri; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Akio Niimi

  Respiratory Medicine Case Reports Elsevier BV 29 100979 - 100979 2213-0071 2020
• Aortoesophageal Fistula Occurring during Lung Cancer Treatment: A Case Treated by Thoracic Endovascular Aortic Repair

  Keima Ito; Tetsuya Oguri; Akiko Nakano; Kensuke Fukumitsu; Satoshi Fukuda; Yoshihiro Kanemitsu; Osamu Takakuwa; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Akio Niimi

  Internal Medicine Japanese Society of Internal Medicine 58 (20) 3025 - 3028 0918-2918 2019/10
• Small airway inflammation is associated with residual airway hyperresponsiveness in Th2-high asthma

  Takamitsu Asano; Yoshihiro Kanemitsu; Masaya Takemura; Kensuke Fukumitsu; Ryota Kurokawa; Yoshitsugu Inoue; Norihisa Takeda; Jennifer Maries G. Yap; Keima Ito; Yuki Kitamura; Satoshi Fukuda; Hirotsugu Ohkubo; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Akio Niimi

  Journal of Asthma Informa UK Limited 57 (9) 933 - 941 0277-0903 2019/06
• A suspected case of inflammatory bronchial polyp induced by bronchial thermoplasty but resolved spontaneously

  Akira Takeuchi; Yoshihiro Kanemitsu; Osamu Takakuwa; Keima Ito; Yuki Kitamura; Yoshitsugu Inoue; Norihisa Takeda; Kensuke Fukumitsu; Takamitsu Asano; Satoshi Fukuda; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Tetsuya Oguri; Akio Niimi

  Journal of Thoracic Disease AME Publishing Company 10 (9) E678 - E681 2072-1439 2018/09
• Predictive and Prognostic Value of CYFRA 21-1 for Advanced Non-small Cell Lung Cancer Treated with EGFR-TKIs

  Akira Takeuchi; Tetsuya Oguri; Kazuki Sone; Keima Ito; Yuki Kitamura; Yoshitsugu Inoue; Takamitsu Asano; Satoshi Fukuda; Yoshihiro Kanemitsu; Osamu Takakuwa; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Akio Niimi

  Anticancer Research 37 (10) 0250-7005 2017/10
• Predictive Role of CYFRA21-1 and CEA for Subsequent Docetaxel in Non-small Cell Lung Cancer Patients

  Kazuki Sone; Tetsuya Oguri; Keima Ito; Yuki Kitamura; Yoshitsugu Inoue; Akira Takeuchi; Satoshi Fukuda; Osamu Takakuwa; Ken Maeno; Takamitsu Asano; Yoshihiro Kanemitsu; Hirotsugu Ohkubo; Masaya Takemura; Yutaka Ito; Akio Niimi

  Anticancer Research 37 (9) 0250-7005 2017/09

Conference Activities & Talks

• The Impact of Treatable Traits on Antitussive Rate in Chronic Cough

  Keima Ito; Yoshihiro Kanemitsu; Yuki Amakusa; Tatsuro Suzuki; Yuta Mori; Kensuke Fukumitsu; Satoshi Fukuda; Takehiro Uemura; Tomoko Tajiri; Yutaka Ito; Akio Niimi

  American Thoracic Society 2025 International Conference  2025/05
• Functional Dyspepsia Is a Comorbidity Reflecting IL-33-mediated Airway Neuronal Dysfunction in Asthma

  Keima Ito, Yoshihiro Kanemitsu, Takashi Ueda, Takeshi Kamiya, Eiji Kubota, Yuta Mori, Kensuke Fukumitsu, Tomoko Tajiri, Shinya Ugawa, Akio Niimi

  American Thoracic Society 2024 International Conference  2024/05
• Targeting the IL-5 pathway improves cough hypersensitivity in patients with severe uncontrolled asthma

  Keima Ito; Yoshihiro Kanemitsu; Tatsuro Suzuki; Yuta Mori; Kensuke Fukumitsu; Satoshi Fukuda; Takehiro Uemura; Tomoko Tajiri; Yutaka Ito; Akio Niimi

  British Thracic Society Winter Meeting 2023  2023/11
• Residual dyspnea may predict small airways dysfunction and poor responsiveness to single-inhaler triple therapy in asthmatic patients

  Keima Ito; Tomoko Tajiri; Tatsuro Suzuki; Yuta Mori; Kensuke Fukumitsu; Satoshi Fukuda; Yoshihiro Kanemitsu; Takehiro Uemura; Masaya Takemura; Yutaka Ito; Tetsuya Oguri; Akio Niimi

  American Thoracic Society 2023 International Conference  2023/05
• Functional gastrointestinal disorders affect capsaicin cough reflex sensitivity in severe asthma

  Keima Ito; Yoshihiro Kanemitsu; Akio Niimi

  International Collaborative Asthma Network Young Researchers Forum  2022/05
• Retrospective study of the current status and short-term effectiveness of single-inhaler triple therapy for asthma or asthma and COPD overlap

  Keima Ito; Tomoko Tajiri; Hirono Nishiyama; Ryota Kurokawa; Norihisa Takeda; Kensuke Fukumitsu; Yoshihiro Kanemitsu; Satoshi Fukuda; Takehiro Uemura; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Akio Niimi

  The 25th Congress of the Asian Pacific Society of Respirology  2021/11
• Procaterol / Budesonide combined nebulizer inhalation therapy shortens hospitalization for asthma attacks

  Keima Ito; Yoshihiro Kanemitsu; Yoshitsugu Inoue; Sayaka Yamamoto; Hirono Nishiyama; Ryota Kurokawa; Norihisa Takeda; Kensuke Fukumitsu; Satoshi Fukuda; Hirotsugu Ohkubo; Masaya Takemura; Ken Maeno; Yutaka Ito; Akio Niimi

  American Thoracic Society 2019 International Conference  2019/05

MISC

• IL-33 mediated airway neuronal dysfunction in asthma with functional dyspepsia

  伊藤圭馬; 金光禎寛  Clinical Immunology & Allergology  83-  (3)  283  -291  2025/03
• 嚥下性肺炎を契機に診断に至った筋萎縮性側索硬化症の1例

  伊藤圭馬; 小林玄弥; 川口裕子; 竹山慎二  総合診療  29-  (6)  2019

Awards & Honors

• 2024/09 Japan Cough Society Best Presentation Award at the 26th Annual Conference of the Japan Cough Society
  
• 2022/04 Japanese Society of Allergology The 18th Japanese Society of Allergology Award
  

Research Grants & Projects

• 喘息病態のバイオマーカーとしての血清胆汁酸の意義

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2025/04 -2028/03 

  Author : 伊藤 圭馬
• 喘息病態における気道神経機能不全の発症メカニズムの解明と治療戦略の探索

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2024/07 -2026/03 

  Author : 伊藤 圭馬
• 知覚神経機能不全に着目した、喘息と機能性ディスペプシアの病態連関の検討

  日本呼吸器学会：喘息研究支援プログラムB

  Date (from‐to) : 2023/12 -2024/11 

  Author : 伊藤 圭馬

Other link

researchmap

https://researchmap.jp/48691116