HAYASHI Noriyuki

Researcher Information

J-Global ID

• 202101013290977582

Research Interests

• 光線力学療法   消化器内視鏡   化学療法   肝癌   胆道癌   膵癌   大腸癌   小腸癌   胃癌   食道癌   

Research Areas

• Life sciences / Tumor diagnostics and therapeutics

Education

• 2015/03 -   Nagoya City University
• 2004/03 -   名古屋市立大学医学部医学科

Association Memberships

• 日本光線力学学会   日本レーザー医学会   日本癌学会   日本内科学会   日本消化管学会   日本内視鏡学会   日本消化器病学会   

Published Papers

• Phase II Prospective Study of Trastuzumab in Combination with S-1 and Oxaliplatin (SOX100) Therapy for HER2-Positive Advanced Gastric Cancer.

  Yoshinori Mori; Hiromi Kataoka; Masahide Ebi; Kazunori Adachi; Yoshiharu Yamaguchi; Noriyuki Hayashi; Yoshikazu Hirata; Satoshi Sobue; Ryo Ishihara; Yuta Suzuki; Takashi Mizushima; Yusuke Inoue; Izumi Hasegawa; Satoshi Ono; Atsuyuki Hirano; Yoshihide Kimura; Kyoji Seno; Keiji Ozeki; Takaya Shimura; Eiji Kubota

  Journal of gastrointestinal cancer 53 (4) 930 - 938 2021/09
• Long-term outcomes of nasogastric tube with Gastrografin for adhesive small bowel obstruction.

  Hirotada Nishie; Takaya Shimura; Takahito Katano; Tomohiro Iwai; Keisuke Itoh; Masahide Ebi; Yusuke Mizuno; Shozo Togawa; Shunsuke Shibata; Tomonori Yamada; Takashi Mizushima; Yusuke Inagaki; Mika Kitagawa; Yu Nojiri; Yoshito Tanaka; Yasuyuki Okamoto; Sho Matoya; Yoshihito Nagura; Yuki Inagaki; Hiroki Koguchi; Satoshi Ono; Keiji Ozeki; Noriyuki Hayashi; Shuji Takiguchi; Hiromi Kataoka

  Journal of gastroenterology and hepatology 37 (1) 111 - 116 2021/09
• Optimal definition of coagulation syndrome after colorectal endoscopic submucosal dissection: a post hoc analysis of randomized controlled trial.

  Takahito Katano; Takaya Shimura; Satoshi Nomura; Tomohiro Iwai; Yusuke Mizuno; Tomonori Yamada; Masahide Ebi; Yoshikazu Hirata; Hirotada Nishie; Takashi Mizushima; Yu Nojiri; Shozo Togawa; Hiroki Koguchi; Shunsuke Shibata; Noriyuki Hayashi; Keisuke Itoh; Hiromi Kataoka

  International journal of colorectal disease 36 (7) 1479 - 1485 2021/07
• The first management using intubation of a nasogastric tube with Gastrografin enterography or long tube for non-strangulated acute small bowel obstruction: a multicenter, randomized controlled trial.

  Takahito Katano; Takaya Shimura; Hirotada Nishie; Tomohiro Iwai; Keisuke Itoh; Masahide Ebi; Yusuke Mizuno; Shozo Togawa; Shunsuke Shibata; Tomonori Yamada; Takashi Mizushima; Yusuke Inagaki; Mika Kitagawa; Yu Nojiri; Yoshito Tanaka; Yasuyuki Okamoto; Miyuki Sugiura; Sho Matoya; Yoshihito Nagura; Yuki Inagaki; Hiroki Koguchi; Satoshi Ono; Keiji Ozeki; Noriyuki Hayashi; Shuji Takiguchi; Hiromi Kataoka

  Journal of gastroenterology 55 (9) 858 - 867 2020/09
• 術前診断に難渋した胃plexiform fibromyxomaの一例

  鈴木 健人; 野村 智史; 市川 鉱; 野尻 優; 稲垣 佑祐; 岩崎 弘靖; 林 則之; 西江 裕忠; 片野 敬仁; 田中 守; 岡本 泰幸; 尾関 啓司; 溝下 勤; 志村 貴也; 久保田 英嗣; 谷田 諭史; 片岡 洋望; 城 卓志

  日本消化管学会雑誌 (一社)日本消化管学会 2 (Suppl.) 332 - 332 2433-3840 2018/02
• PDTとドラッグデリバリーシステム 腫瘍集積性および排泄能を向上させた次世代光感受性物質による光線力学療法の有用性

  西江 裕忠; 片岡 洋望; 林 則之; 田中 守; 矢野 重信; 野元 昭宏; 城 卓志

  日本レーザー医学会誌 (NPO)日本レーザー医学会 38 (3) 344 - 344 0288-6200 2017/10
• Ectopic Gastric and Intestinal Phenotypes, Neuroendocrine Cell Differentiation, and SOX2 Expression Correlated With Early Tumor Progression in Colorectal Laterally Spreading Tumors.

  Takahito Katano; Tsutomu Mizoshita; Hironobu Tsukamoto; Hirotada Nishie; Yusuke Inagaki; Noriyuki Hayashi; Satoshi Nomura; Keiji Ozeki; Yasuyuki Okamoto; Takaya Shimura; Yoshinori Mori; Eiji Kubota; Satoshi Tanida; Hiromi Kataoka; Toshiya Kuno; Satoru Takahashi; Takashi Joh

  Clinical colorectal cancer 16 (2) 141 - 146 2017/06
• Maltotriose Conjugation to a Chlorin Derivative Enhances the Antitumor Effects of Photodynamic Therapy in Peritoneal Dissemination of Pancreatic Cancer.

  Akihisa Kato; Hiromi Kataoka; Shigenobu Yano; Kazuki Hayashi; Noriyuki Hayashi; Mamoru Tanaka; Itaru Naitoh; Tesshin Ban; Katsuyuki Miyabe; Hiromu Kondo; Michihiro Yoshida; Yasuaki Fujita; Yasuki Hori; Makoto Natsume; Takashi Murakami; Atsushi Narumi; Akihiro Nomoto; Aya Naiki-Ito; Satoru Takahashi; Takashi Joh

  Molecular cancer therapeutics 16 (6) 1124 - 1132 2017/06
• Urinary kallikrein 10 predicts the incurability of gastric cancer.

  Takaya Shimura; Masahide Ebi; Tomonori Yamada; Tamaki Yamada; Takahito Katano; Yu Nojiri; Hiroyasu Iwasaki; Satoshi Nomura; Noriyuki Hayashi; Yoshinori Mori; Hiromi Kataoka; Marsha A Moses; Takashi Joh

  Oncotarget 8 (17) 29247 - 29257 2017/04
• New photodynamic therapy with next-generation photosensitizers.

  Hiromi Kataoka; Hirotada Nishie; Noriyuki Hayashi; Mamoru Tanaka; Akihiro Nomoto; Shigenobu Yano; Takashi Joh

  Annals of translational medicine 5 (8) 183 - 183 2017/04
• A next-generation bifunctional photosensitizer with improved water-solubility for photodynamic therapy and diagnosis.

  Hirotada Nishie; Hiromi Kataoka; Shigenobu Yano; Jun-Ichi Kikuchi; Noriyuki Hayashi; Atsushi Narumi; Akihiro Nomoto; Eiji Kubota; Takashi Joh

  Oncotarget 7 (45) 74259 - 74268 2016/11
• Anticancer Effects of a New Aminosugar-conjugated Platinum Complex Agent Against Cisplatin-resistant Gastric Cancer.

  Noriyuki Hayashi; Hiromi Kataoka; Shigenobu Yano; Jun-Ichi Kikuchi; Mamoru Tanaka; Hirotada Nishie; Yuma Kinoshita; Miki Hatano; Akihiro Nomoto; Akiya Ogawa; Masahiro Inoue; Tsutomu Mizoshita; Takaya Shimura; Yoshinori Mori; Eiji Kubota; Satoshi Tanida; Takashi Joh

  Anticancer research 36 (11) 6005 - 6009 2016/11
• オリゴ糖連結光感受性物質を用いた次世代光線力学療法の検討

  西江 裕忠; 片岡 洋望; 林 則之; 市川 紘; 林 香月; 久保田 英嗣; 鳴海 敦; 野元 昭宏; 矢野 重信; 城 卓志

  日本レーザー医学会誌 (NPO)日本レーザー医学会 37 (3) 361 - 361 0288-6200 2016/09
• Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin).

  Mamoru Tanaka; Hiromi Kataoka; Shigenobu Yano; Takuya Sawada; Haruo Akashi; Masahiro Inoue; Shugo Suzuki; Yusuke Inagaki; Noriyuki Hayashi; Hirotada Nishie; Takaya Shimura; Tsutomu Mizoshita; Yoshinori Mori; Eiji Kubota; Satoshi Tanida; Satoru Takahashi; Takashi Joh

  Oncotarget 7 (30) 47242 - 47251 2016/07
• Preventive effect of rebamipide on N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in rats.

  Hironobu Tsukamoto; Tsutomu Mizoshita; Takahito Katano; Noriyuki Hayashi; Keiji Ozeki; Masahide Ebi; Takaya Shimura; Yoshinori Mori; Satoshi Tanida; Hiromi Kataoka; Tetsuya Tsukamoto; Masae Tatematsu; Takashi Joh

  Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 67 (3) 271 - 7 2015/03
• A novel photodynamic therapy targeting cancer cells and tumor-associated macrophages.

  Noriyuki Hayashi; Hiromi Kataoka; Shigenobu Yano; Mamoru Tanaka; Kazuhiro Moriwaki; Haruo Akashi; Shugo Suzuki; Yoshinori Mori; Eiji Kubota; Satoshi Tanida; Satoru Takahashi; Takashi Joh

  Molecular cancer therapeutics 14 (2) 452 - 60 2015/02
• 4. 過敏性腸症候群における自律神経機能の検討(一般演題,第70回日本心身医学会中部地方会演題抄録)

  神谷 武; 鹿野 美千子; 田中 守; 林 則之; 濱野 真吾; 西脇 裕高; 尾関 啓司; 塚本 宏延; 海老 正秀; 溝下 勤; 森 義徳; 谷田 諭史; 片岡 洋望; 城 卓志

  心身医学 一般社団法人 日本心身医学会 55 (9) 1071 - 1071 2015
• Tumor Affinity Photosensitizers for Photodynamic Therapy

  Kataoka Hiromi; Hayashi Noriyuki; Tanaka Mamoru; Kubota Eiji; Yano Shigenobu; Joh Takashi

  Nippon Laser Igakkaishi Japan Society for Laser Surgery and Medicine 36 (2) 159 - 165 2015
• Antitumor effects in gastrointestinal stromal tumors using photodynamic therapy with a novel glucose-conjugated chlorin.

  Mamoru Tanaka; Hiromi Kataoka; Shigenobu Yano; Hiromi Ohi; Kazuhiro Moriwaki; Haruo Akashi; Takahiro Taguchi; Noriyuki Hayashi; Shingo Hamano; Yoshinori Mori; Eiji Kubota; Satoshi Tanida; Takashi Joh

  Molecular cancer therapeutics 13 (4) 767 - 75 2014/04
• 癌間質腫瘍関連マクロファージを標的とした新規光線力学的治療の基礎的検討

  林 則之; 片岡 洋望; 田中 守; 林 香月; 矢野 重信; 城 卓志

  日本レーザー医学会誌 (NPO)日本レーザー医学会 34 (3) 254 - 254 0288-6200 2013/10
• Diagnostic utility of small-caliber and conventional endoscopes for gastric cancer and analysis of endoscopic false-negative gastric cancers.

  Hiromi Kataoka; Kiyoshi Mizuno; Noriyuki Hayashi; Mamoru Tanaka; Hirotaka Nishiwaki; Masahide Ebi; Tsutomu Mizoshita; Yoshinori Mori; Eiji Kubota; Satoshi Tanida; Takeshi Kamiya; Takashi Joh

  World journal of gastrointestinal endoscopy 5 (9) 440 - 5 2013/09

MISC

• EVALUATION OF THE EFFICACY AND SAFETY OF HELICOBACTOR PYLORI ERADICATION WITH VONOPRAZAN, A NOVEL POTASSIUM-COMPETITIVE ACID BLOCKER

  Hirotada Nishie; Keiji Ozeki; Hiromi Kataoka; Hiroshi Ichikawa; Yu Nojiri; Yusuke Inagaki; Satoshi Nomura; Noriyuki Hayashi; Takahito Katano; Yasuyuki Okamoto; Tsutomu Mizoshita; Takaya Shimura; Yoshinori Mori; Eiji Kubota; Satoshi Tanida; Takashi Joh  GASTROENTEROLOGY  152-  (5)  S246  -S247  2017/04
• Anti-Tumor Effect of Oncolytic Reovirus Against Gastrointestinal Stromal Tumor

  Yusuke Inagaki; Eiji Kubota; Yoshinori Mori; Hirotada Nishie; Noriyuki Hayashi; Takahito Katano; Keiji Ozeki; Hiromi Kataoka; Randal N. Johnston; Takashi Joh  GASTROENTEROLOGY  150-  (4)  S869  -S869  2016/04
• Cancer cell selective photodynamic therapy using glucose-conjugated and oligosaccharide-conjugated chlorins

  H. Kataoka; N. Hayashi; M. Tanaka; E. Kubota; S. Yano; T. Joh  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  30-  4  -4  2015/12
• Cancer cell specific and selective photodynamic therapy using newly developed glucose- and oligosaccharide-conjugated chlorins

  H. Kataoka; N. Hayashi; E. Kubota; M. Tanaka; S. Yano; Y. Sakai; T. Joh  EUROPEAN JOURNAL OF CANCER  51-  S63  -S64  2015/09
• A Novel Photodynamic Therapy Targeting Tumor-Associated Macrophages

  Noriyuki Hayashi; Hiromi Kataoka; Shigenobu Yano; Mamoru Tanaka; Takashi Joh  GASTROENTEROLOGY  148-  (4)  S949  -S949  2015/04
• 消化器癌におけるレーザー光を用いた診断・治療 消化器癌に対するPDD,PDT...光感受性物質の現状と将来展望

  片岡洋望; 林則之; 田中守; 久保田英嗣; 矢野重信; 城卓志  G.I. Research  23-  (4)  2015
• Effectiveness of combination therapy with adalimumab plus intensive granulocyte and monocyte adsorptive apheresis in patients with crohn's disease

  Keiji Ozeki; Satoshi Tanida; Tsutomu Mizoshita; Hironobu Tsukamoto; Takahito Katano; Noriyuki Hayashi; Mamoru Tanaka; Hirotaka Nishiwaki; Masahide Ebi; Takeshi Sawada; Yoshinori Mori; Eiji Kubota; Hiromi Kataoka; Takashi Joh  JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY  29-  133  -133  2014/11
• Enhanced antitumor effects of oncolytic reovirus and trastuzumab combination therapy in human HER2-positive gastric cancer

  H. Kataoka; S. Hamano; M. Aoyama; Y. Mori; M. Tanaka; N. Hayashi; E. Kubota; R. Johnston; T. Joh  EUROPEAN JOURNAL OF CANCER  50-  S183  -S183  2014/07

Awards & Honors

• 2014/12 第9回消化管の炎症を考える会 ICAT Award 優秀賞
  

Research Grants & Projects

• Elucidation of mechanisms underlying angiogenesis is important for the development of new anti-angiogenic drugs

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2018/04 -2021/03 

  Author : Hayashi Noriyuki

   

  Elucidation of mechanisms underlying angiogenesis is important for the development of new anti-angiogenic drugs. Here, we found that EIF3D, a critical translational factor, is ubiquitinated by the cullin-3 (CUL3)/KCTD10 ubiquitin ligase complex in both endothelial cells and hepatocellular carcinoma cells. Knockdown of EIF3D in endothelial cells drastically inhibited tube formation of endothelial cells, that mimics angiogenesis in vitro. Our results suggest that CUL3/KCTD10/EIF3D would be a promising target for development of novel anti-angiogenic drugs.
• A novel photodynamic therapy targeting tumor-associated macrophages

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2016/04 -2019/03 

  Author : Hayashi Noriyuki

   

  Photodynamic therapy (PDT) is an attractive, minimally invasive modality for cancer treatment that utilizes the interaction of light and photosensitizer. To improve the efficacy of PDT, development of cancer specificity and selectivity of the photosensitizer is needed. Macrophages migrating to tumor stroma are called tumor-associated macrophages (TAMs). TAMs play several pro-tumoral roles including tumor cell growth, angiogenesis, matrix remodeling, and metastases. TAMs are known to specifically express abundant levels of CD206, a mannose receptor.We evaluated the anticancer effects of targeting TAM via PDT with M-chlorin. The specific suppression of TAM in cancer stroma significantly suppressed tumor growth in allograft models. Such therapeutic targeting of TAMs as well as cancer cells may represent a new strategy for anticancer therapy.

Other link

researchmap

https://researchmap.jp/nori53412