Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2020/09 -2022/03
Author : Aoki Hiromasa
M-chlorin e6 PDT decreased the proportion of cancer-promoting M2-TAMs and increased the proportion of tumor-suppressing M1-TAMs in the mouse tumor tissue. In addition, M-chlorin e6 PDT promoted the expression of CRT on the surface of cancer cells and increased phagocytosis by macrophages. These results indicate that M-chlorin e6 PDT activates tumor immunity through multiple pathways, including the reduction of M2-TAMs.