HIYOSHI Hiromi

Researcher Information

Degree

• Master (Pharmacy)（Kobe Gakuin University）

J-Global ID

• 200901040169526451

Research Interests

• ユビキチンリガーゼ   がん   cardiovascular   angiotensinII   bradykinin   

Research Areas

• Life sciences / Molecular biology

Academic & Professional Experience

• 2015/04 - Today  Nagoya City UniversityGraduate School of Medical Sciences特任助教
• 2013/04 - 2015/03  University of TsukubaFaculty of Life and Environmental Sciences助教
• 2009/05 - 2013/03  University of TsukubaFaculty of Life and Environmental Sciences非常勤研究員
• 2006/06 - 2009/04  Karolinska Institutetポスドク
• 2008/01 - 2008/12  Karolinska Institutet上原記念生命科学財団海外留学助成ポストドクトラルフェロー
• 2005/04 - 2006/05  Saitama Medical UniversityResearch Center for Genomic Medicineリサーチフェロー

Education

• 2002/04 - 2005/03  Kobe Gakuin University  The Graduate School of Food and Medicinal Sciences
• 2000/04 - 2002/03  Kobe Gakuin University  The Graduate School of Pharmaceutical Sciences
•        - 2002  Kobe Gakuin University  Graduate School, Division of Pharmaceutical Sciences  Pharmacology
• 1996/04 - 2000/03  Kobe Gakuin University  The Faculty of Pharmaceutical Sciences  Department of Biopharmacy
•        - 2000  Kobe Gakuin University  Faculty of Pharmaceutical Science  Pharmacuetical Sciences

Association Memberships

• THE JAPANESE CANCER ASSOCIATION   THE MOLECULAR BIOLOGY SOCIETY OF JAPAN   The Japanese Pharmacological Society   

Published Papers

• Neddylated Cullin 3 is required for vascular endothelial-cadherin-mediated endothelial barrier function

  Tomohisa Sakaue; Ayako Fujisaki; Hironao Nakayama; Masashi Maekawa; Hiromi Hiyoshi; Eiji Kubota; Takashi Joh; Hironori Izutani; Shigeki Higashiyama

  CANCER SCIENCE 108 (2) 208 - 215 1347-9032 2017/02 [Refereed]
  
• Prognostic value of the ubiquitin ligase carboxyl terminus of the Hsc70-interacting protein in postmenopausal breast cancer

  Sasagu Kurozumi; Yuri Yamaguchi; Shin-ichi Hayashi; Hiromi Hiyoshi; Tetsuji Suda; Tatsuyuki Gohno; Hiroshi Matsumoto; Hiroyuki Takei; Jun Horiguchi; Izumi Takeyoshi; Tetsunari Oyama; Masafumi Kurosumi

  CANCER MEDICINE 5 (8) 1873 - 1882 2045-7634 2016/08 [Refereed]
  
• CHIP buffers heterogeneous Bcl-2 expression levels to prevent augmentation of anticancer drug-resistant cell population

  M. Tsuchiya; Y. Nakajima; T. Waku; H. Hiyoshi; T. Morishita; R. Furumai; Y. Hayashi; H. Kishimoto; K. Kimura; J. Yanagisawa

  ONCOGENE 34 (35) 4656 - 4663 0950-9232 2015/08 [Refereed]
  
• 2-(4-Hydroxy-3-methoxyphenyl)-benzothiazole suppresses tumor progression and metastatic potential of breast cancer cells by inducing ubiquitin ligase CHIP

  Hiromi Hiyoshi; Natsuka Goto; Mai Tsuchiya; Keisuke Iida; Yuka Nakajima; Naoya Hirata; Yasunari Kanda; Kazuo Nagasawa; Junn Yanagisawa

  SCIENTIFIC REPORTS 4 7095  2045-2322 2014/11 [Refereed]
  
• Hepatic rRNA Transcription Regulates High-Fat-Diet-Induced Obesity

  Shohei Oie; Kazuya Matsuzaki; Wataru Yokoyama; Shinji Tokunaga; Tsuyoshi Waku; Song-Iee Han; Naoya Iwasaki; Aya Mikogai; Kayoko Yasuzawa-Tanaka; Hiroyuki Kishimoto; Hiromi Hiyoshi; Yuka Nakajima; Toshiyuki Araki; Keiji Kimura; Junn Yanagisawa; Akiko Murayama

  CELL REPORTS 7 (3) 807 - 820 2211-1247 2014/05 [Refereed]
  
• Identification of a Novel Compound That Suppresses Breast Cancer Invasiveness by Inhibiting Transforming Growth Factor-beta Signaling via Estrogen Receptor alpha

  Natsuka Goto; Hiromi Hiyoshi; Ichiaki Ito; Keisuke Iida; Yuka Nakajima; Kazuo Nagasawa; Junn Yanagisawa

  JOURNAL OF CANCER 5 (5) 336 - 343 1837-9664 2014 [Refereed]
  
• Reply: Comment on 'Quiescence and yH2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase': ouabain and cancer

  H. Hiyoshi; J. I. Johnsen; M. Andang; P. Uhlen

  BRITISH JOURNAL OF CANCER 108 (10) 2191 - 2191 0007-0920 2013/05 [Refereed]
  
• Quiescence and gamma H2AX in neuroblastoma are regulated by ouabain/Na,K-ATPase

  H. Hiyoshi; S. Abdelhady; L. Segerstrom; B. Sveinbjornsson; M. Nuriya; T. K. Lundgren; L. Desfrere; A. Miyakawa; M. Yasui; P. Kogner; J. I. Johnsen; M. Andang; P. Uhlen

  BRITISH JOURNAL OF CANCER 106 (11) 1807 - 1815 0007-0920 2012/05 [Refereed]
  
• Estrogen and antiestrogens alter breast cancer invasiveness by modulating the transforming growth factor-beta signaling pathway

  Natsuka Goto; Hiromi Hiyoshi; Ichiaki Ito; Mai Tsuchiya; Yuka Nakajima; Junn Yanagisawa

  CANCER SCIENCE 102 (8) 1501 - 1508 1347-9032 2011/08 [Refereed]
  
• Na,K-ATPase signal transduction triggers CREB activation and dendritic growth

  Luc Desfrere; Marie Karlsson; Hiromi Hiyoshi; Seth Malmersjo; Evanthia Nanou; Manuel Estrada; Ayako Miyakawa; Hugo Lagercrantz; Abdeljabbar El Manira; Mark Lal; Per Uhlen

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106 (7) 2212 - 2217 0027-8424 2009/02 [Refereed]
  
• Angiotensin II stimulates endothelial NO synthase phosphorylation in thoracic aorta of mice with abdominal aortic banding via type 2 receptor

  Katsutoshi Yayama; Hiromi Hiyoshi; Daichi Imazu; Hiroshi Okamoto

  HYPERTENSION 48 (5) 958 - 964 0194-911X 2006/11 [Refereed]
  
• The lipopolysaccharide-induced up-regulation of bradykinin B-2-receptor in the mouse heart is mediated by tumor necrosis factor-alpha and angiotensin

  Katsutoshi Yayama; Hiromi Hiyoshi; Kaori Sugiyama; Hiroshi Okamoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN 29 (6) 1143 - 1147 0918-6158 2006/06 [Refereed]
  
• Angiotensin type 2 receptor-mediated phosphorylation of eNOS in the aortas of mice with 2-kidney, 1-clip hypertension

  H Hiyoshi; K Yayama; M Takano; H Okamoto

  HYPERTENSION 45 (5) 967 - 973 0194-911X 2005/05 [Refereed]
  
• Stimulation of cyclic GMP production via AT(2) and B-2 receptors in the pressure-overloaded aorta after banding

  H Hiyoshi; K Yayama; M Takano; H Okamoto

  HYPERTENSION 43 (6) 1258 - 1263 0194-911X 2004/06
• Up-regulation of angiotensin II type 2 receptor in rat thoracic aorta by pressure-overload

  K Yayama; M Horii; H Hiyoshi; M Takano; H Okamoto; S Kagota; M Kunitomo

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 308 (2) 736 - 743 0022-3565 2004/02
• Expressions of bradykinin B2-receptor, kallikrein and kininogen mRNAs in the heart are altered in pressure-overload cardiac hypertrophy in mice

  K Yayama; H Hiyoshi; H Okamoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN 24 (1) 34 - 38 0918-6158 2001/01 [Refereed]
  

MISC

• Up-regulation of angiotensin II type 2 receptor in rat thoracic aorta by pressure-overload

  K Yayama; M Horii; H Hiyoshi; M Takano; H Okamoto; S Kagota; M Kunitomo  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS  308-  (2)  736  -743  2004/02
• Expressions of Bradykinun B2-Receptor, Kallikvein and Kininogen mRNAs in the Heart Are Altered in Pressure-Overload Cardiac Hypertrophy in Mice.

  Biological & Pharmaceutical Bulletin  24(1), 34-38.-  2001

Research Grants & Projects

• 脳腫瘍におけるアルギニンメチル化酵素の役割

  科学研究費補助金 若手研究B

  Date (from‐to) : 2015/04 -2018/03 

  Author : 日吉 裕美
• 乳癌におけるダイオキシン受容体を介した増殖および浸潤・転移抑制メカニズムの解明

  科学研究費補助金 研究活動スタート支援

  Date (from‐to) : 2013 -2015/03 

  Author : 日吉 裕美
• Study on cardiovascular disease

  Special Postdoctoral Researchers Program

  Date (from‐to) : 2000 -2005

Other link

researchmap

https://researchmap.jp/read0098852