Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2014/04 -2018/03
Author : Hattori Tomonori
In septic shock patients, serial blood samples were obtained on days 1, 3, and 7 after the onset of shock, and immune cell subsets and receptor expression were characterized. A decrease of immunoactivity of T cells and monocyte were observed in the early stage of septic shock. Significant lymphopenia persisted for at least 7 days following the onset of septic shock. Normalization of immunodysfunctions was observed by day 7, except in patients who died. Our findings emphasize the importance of normal lymphocyte function for recovery from septic shock. These results indicate that the regeneration of the immunoparalytic state by bone-marrow transplantation, can be potentially effective therapy for recovery from septic shock.