Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2014/04 -2017/03
Author : So MinHye
We aimed to elucidate the pathogenesis of higher brain dysfunction accompanying severe infection and establish a new treatment strategy.
The expression of aquaporin 9 (AQP 9), a water channel, was confirmed to be decreased by administration of inflammatory cytokine or endotoxin to cultured cells. In addition, we confirmed elevation of inflammatory cytokine and decreased expression of AQP9 in the brain of sepsis model mouse, and the decrease of AQP 9 could be suppressed by administration of dexamethasone. Next, behavioral experiments of sepsis model mice confirmed higher brain dysfunction, and an improvement trend was confirmed by administration of dexamethasone. Furthermore, endotoxin was administered to cultured astrocytes, cDNA microarray was performed, and many factors whose expression fluctuated were confirmed, so we will narrow down.