IWASE Tamaki

Researcher Information

J-Global ID

• 202301020976469894

Research Interests

• dementia   Fahr's syndrome   Alzheimer disease   neuropathology   neurology   

Research Areas

• Life sciences / Human pathology / neuropathology
• Life sciences / Neurology

Academic & Professional Experience

• 2025/04 - Today  名古屋市立大学医学部保健医療学科リハビリテーション学専攻神経内科学分野教授
• 2023/04 - 2025/03  名古屋市立大学医学部附属みらい光生病院神経内科学分野教授

Education

• 1995/04 - 2000/03  名古屋市立大学大学院  医学研究科
• 1982/04 - 1988/03  Nagoya City University  医学部  医学科

Association Memberships

• Society for Neuroscience   日本神経病理学会   日本神経学会   日本内科学会   

Published Papers

• Severe cerebrovascular pathology of the first supercentenarian to be autopsied in the world

  Tamaki Iwase; Mari Yoshida; Yoshio Hashizume; Toshiaki Inagaki; Yasushi Iwasaki

  Neuropathology 43 181 - 189 2023 [Refereed]
  
• Sloping Shoulders Sign: A Practical Radiological Sign for the Differentiation of Alzheimer's Disease and Argyrophilic Grain Disease.

  Sakurai K; Iwase T; Kaneda D; Uchida Y; Inui S; Morimoto S; Kimura Y; Kato T; Nihashi T; Ito K; Hashizume Y

  J Alzheimers Dis. 84 1719 - 1727 2021 [Refereed]
  
• Selective extension of cerebral vascular calcification in an autopsy case of Fahr's syndrome associated with asymptomatic hypoparathyroidism.

  Iwase T; Yoshida M; Iwasaki Y; Suzuki S; Yabata H; Koizumi R; Moriyoshi H; Yazawa I

  Neuropathology 41 387 - 395 2021 [Refereed]
  
• Intracranial vascular calcification with extensive white matter changes in an autopsy case of pseudopseudohypoparathyroidism.

  Iwase T; Yoshida M; Hashizume Y; Yazawa I; Takahashi S; Ando T; Ikeda T; Nokura K

  Neuropathology 39 39 - 46 2019 [Refereed]
  
• An autopsy case of hemiconvulsion-hemiplegia-epilepsy syndrome manifesting as cerebral hemiatrophy in an elderly man.

  Iwase T; Yoshida M; Mizuno T; Sato S; Nokura K

  Neuropathology 35 592 - 598 2015 [Refereed]
  
• β-III Tubulin fragments inhibit α-synuclein accumulation in models of multiple system atrophy.

  Suzuki Y; Jin C; Iwase T; Yazawa I

  J Biol Chem. 289 24374 - 24382 2014 [Refereed]
  
• Characteristics of alpha-synucleinopathy in centenarians.

  Ding ZT; Wang Y; Jiang YP; Hashizume Y; Yoshida M; Mimuro M; Inagaki T; Iwase T

  Acta Neuropathol. 111 450 - 458 2006 [Refereed]
  
• Argyrophilic grain disease: Frequency and neuropathology in centenarians.

  Ding ZT; Wang Y; Jiang YP; Yoshida M; Mimuro M; Inagaki T; Iwase T; Hashizume Y

  Acta Neuropathol. 111 320 - 328 2006 [Refereed]
  
• Trak1 mutation disrupts GABAA receptor homeostasis in hypertonic mice.

  Gilbert SL; Zhang L; Forster ML; Iwase T; Soliven B; Donahue LR; Sweet HO; Bronson RT; Davisson MT; Wollmann RL; Lahn BT

  Nature Genetics 38 245 - 250 2006 [Refereed]
  
• Glial cell line-derived neurotrophic factor-induced signaling in Schwann cells.

  Iwase T; Jung CG; Bae H; Zhang M; Soliven B

  J Neurochem. 94 1488 - 1499 2005 [Refereed]
  
• PDGF upregulates delayed rectifier via Src family kinases and sphingosine kinase in oligodendroglial progenitors.

  Soliven B; Ma L; Bae H; Attali B; Sobko A; Iwase T

  Am J Physiol Cell Physiol 284 C85 - C93 2003 [Refereed]
  
• Spastic tetraparesis in a patient with pseudopseudohypoparathyroidism.

  Iwase T; Nokura K; Mizuno T; Inagaki T

  J Neurol. 249 1457 - 1458 2002 [Refereed]
  
• Muscarinic cholinergic and glutamatergic reciprocal regulation of expression of hippocampal cholinergic neurostimulating peptide precursor protein gene in rat hippocampus.

  Iwase T; Ojika K; Matsukawa N; Nishino H; Yamamoto T; Okada H; Fujimori O; Ueda R

  Neuroscience 102 341 - 352 2001 [Refereed]
  
• Involvement of CD45RO+ T lymphocyte infiltration in a patient with primary angiitis of the central nervous system restricted to small vessels.

  Iwase T; Ojika K; Mitake S; Katada E; Katano H; Mase M; Yoshida S; Ueda R

  Eur Neurol. 45 184 - 185 2001 [Refereed]
  
• High levels of hippocampal cholinergic neurostimulating peptide (HCNP) in the CSF of some patients with Alzheimer's disease.

  Tsugu Y; Ojika K; Matsukawa N; Iwase T; Otsuka Y; Katada E; Mitake S

  Eur J Neurol. 5 561 - 569 1998 [Refereed]
  
• An unusual course of progressive multifocal leukoencephalopathy in a patient with idiopathic CD4+ T lymphocytopenia.

  Iwase T; Ojika K; Katada E; Mitake S; Nakazawa H; Matsukawa N; Otsuka Y; Tsugu Y; Kanai H; Nakajima K

  J Neurol Neurosurg Psychiatry 64 788 - 791 1998 [Refereed]
  
• Mixed connective tissue disease associated with acute polyradiculoneuropathy.

  Katada E; Ojika K; Uemura M; Maeno K; Mitake S; Tsugu Y; Otsuka Y; Iwase T

  Intern Med. 36 118 - 124 1997 [Refereed]
  
• Possible implication of hippocampal cholinergic neurostimulating peptide (HCNP)-related components in Hirano body formation.

  Mitake S; Katada E; Otsuka Y; Matsukawa N; Iwase T; Tsugu T; Fujimori O; Ojika K

  Neuropathol Appl Neurobiol. 22 440 - 445 1996 [Refereed]
  
• Erdheim-Chester disease: a case report with immunohistochemical and biochemical examination.

  Ono K; Oshiro M; Uemura K; Ota H; Matsushita Y; Iijima S; Iwase T; Uchida M; Katsuyama T

  Hum Pathol 27 91 - 95 1996 [Refereed]
  
• Very late onset X-linked recessive bulbospinal neuronopathy: mild clinical features and a mild increase in the size of tandem CAG repeat in androgen receptor gene.

  Doyu M; Sobue G; Mitsuma T; Uchida M; Iwase T; Takahashi A

  J Neurol Neurosurg Psychiatry 56 832 - 833 1993 [Refereed]
  

Books etc

• 神経内科学概論 第２版

  矢澤生; 岩瀬環 (Joint work)一粒書房 2022/08 9784867431115
• Japanese Textbook of Basic Neurology

  矢澤生; 岩瀬環 (Joint work)一粒書房 2020/08

Conference Activities & Talks

• Argyrophilic grain disease does not show the “sloping shoulders sign”  [Not invited]

  T. IWASE

  Neuroscience 2024, Chicago, USA  2024/10
• Severe argyrophilic grain disease in a centenarian with severe dementia who did not show the "sloping shoulders sign"  [Not invited]

  T. Iwase; M. Yoshida; Y. Iwasaki; K.Sakurai; Y. Hashizume; D. Kaneda; K. Adachi; K. Ojika; N. Matsukawa

  The 26th World Congress of Neurology (WCN2023), Montreal, Canada  2023/10
• Severe argyrophilic grain disease in a centenarian with severe dementia who did not show the "sloping shoulders sign"  [Not invited]

  T. Iwase; M. Yoshida; Y. Iwasaki; K.Sakurai; Y. Hashizume; D. Kaneda; K. Adachi; K. Ojika; N. Matsukawa

  20th International Congress of Neuropathology (ICN2023), Berlin • Germany  2023/09
• Calcification of the cerebellar dentate nucleus in Centenarians.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y; Yazawa I

  12th FENS Forum of Neuroscience (FENS 2020 Forum)  2020/07
• Calcification of the basal ganglia in Centenarians.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y; Yazawa I

  Society for neuroscience 49th annual meeting (Neuroscience 2019)  2019/10
• Extensive white matter changes and brainstem calcification in an autopsy case of bilateral striopallidodentate calcinosis (Fahr's syndrome).  [Not invited]

  Iwase T; Yoshida M; Yazawa I

  Society for neuroscience 48th annual meeting (Neuroscience 2018)  2018/11
• Brainstem calcification and extensive white matter changes in an autopsy case of bilateral striopallidodentate calcification with Alzheimer's disease.  [Not invited]

  Iwase T; Yoshida M; Yazawa I

  19th International Congress of Neuropathology (ICN2018)  2018/09
• Intracranial vascular calcification in an autopsy case of pseudopseudohypoparathyroidism.  [Not invited]

  Iwase T; Yoshida M; Hshizume Y; Yazawa I

  Society for neuroscience 47th annual meeting (Neuroscience 2017)  2017/11
• Mouse models contribute to develop a therapeutic strategy for multiple system atrophy.  [Not invited]

  Yazawa I; Jin C; Sasaki A; Iwase T

  XXIII World Congress of Neurology (WCN2017)  2017/09
• Intracranial vascular calcification in an autopsy case of pseudopseudohypoparathyroidism.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y; Yazawa I

  23rd World Congress of Neurology (WCN2017)  2017/09
• TDP-43 pathology in the hippocampus of centenarians.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y

  Society for neuroscience 46th annual meeting (Neuroscience 2016)  2016/11
• Factors contributing to improving the quality of life in dementia-free centenarians.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y

  XXII World Congress of Neurology (WCN2015)  2015/11
• 「神経病理学の原点と進歩」 百歳老人脳の観察から見えてくるもの  [Invited]

  吉田眞理; 岩瀬環

  第 34 回日本認知症学会学術集会  2015/10
• Neuropathological study in dementia-free centenarians.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y

  XVIIIth International Congress of Neuropathology (ICN2014)  2014/09
• Neuropathological study in dementia-free centenarians.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y

  XXI World Congress of Neurology (WCN2013)  2013/09
• Atypical subtype of Alzheimer’s disease in centenarians.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y

  Society for neuroscience 42nd annual meeting (Neuroscience 2012)  2012/10
• Capillary cerebral amyloid angiopathy in centenarians.  [Not invited]

  Iwase T; Yoshida M; Hashizume Y; Ojika K

  Society for neuroscience 41st annual meeting (Neuroscience 2011)  2011/11
• Cerebral amyloid angiopathy in centenarians.  [Not invited]

  Iwase T; Hashizume Y; Yoshida M; Ojika K

  Society for neuroscience 40th annual meeting (Neuroscience 2010)  2010/11
• Neuropathological changes in the spinal cords of centenarians.  [Not invited]

  Iwase T; Hashizume Y; Ojika K; Yoshida M

  XVIIth International Congress of Neuropathology (ICN2010)  2010/09
• TDP-43 proteinopathy in centenarians.  [Not invited]

  Iwase T; Hashizume Y; Ojika K

  Society for neuroscience 39th annual meeting (Neuroscience 2009)  2009/10
• Glial cell line-derived neurotrophic factor-mediated signaling cascades in Schwann cells.  [Not invited]

  Iwase T; Bae H; Soliven B

  Society for neuroscience 33rd annual meeting (Neuroscience 2003)  2003/11
• Possible autocrine signaling of Glial cell line-derived neurotrophic factor in Schwann cells.  [Not invited]

  Iwase T; Zhang M; Bae H; Soliven B

  Society for neuroscience 32nd annual meeting (Neuroscience 2002)  2002/11
• Stimulation in hippocampal pyramidal neuron evokes increases in HCNP precursor protein messenger RNA in CA1 field of rat hippocampal slice.  [Not invited]

  Iwase T; Matsukawa N; Nishino H; Yamamoto T; Okada H; Ojika K

  Society for Neuroscience 29th annual meeting (Neuroscience 1999)  1999/10
• A radiological and clinical study of cerebral infarction.  [Not invited]

  Iwase T; Uchida M

  XVth World Congress of Neurology (WCN1993)  1993/09

Awards & Honors

• 2009/10 Society for Neuroscience Neuroscience 2009 Hot topic
  

Other link

researchmap

https://researchmap.jp/2023-04-01