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ASANO Miki

    Graduate School of Medical Sciences Department of Cardiovascular Surgery
Last Updated :2025/06/21

Researcher Information

J-Global ID

Research Interests

  • 虚血再還流障害 フリーラジカル 肺高血圧 単心室循環 小児心臓移植 異種移植 免疫寛容   

Research Areas

  • Life sciences / Cardiovascular surgery

Academic & Professional Experience

  • 1999 - 2001  Loma Linda University Medical SchoolCardiothoracic Surgeryresearch fellow

Education

  • 1986 - 1989  名古屋市立大学大学院医学研究科外科系専攻
  •        -   Nagoya City University  Graduate School, Division of Medicine

Published Papers

MISC

Research Grants & Projects

  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2024/04 -2029/03 
    Author : 赤津 裕康; 正木 克由規; 三田 有紀子; 河合 憲康; 浅野 実樹; 兼松 孝好; 渡邊 航平; 川出 義浩; 井之上 浩一; 金田 大太; 間辺 利江; 宮崎 景; 稲田 充; 吉子 彰人; 大原 弘隆
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2013/04 -2017/03 
    Author : MISHIMA Akira; ISHIDA Akimasa
     
    In cardiac surgery of children with anomaly of the aortic arch, brain blood is supplied by a particular method, called selective cerebral perfusion under using cardiopulmonary bypass. We devised a simple selective cerebral perfusion model on rats. To develop an adequate procedure for children with cyanosis, we conducted experiment on selective cerebral perfusion in juvenile rats bred under hypoxic environment. Neural damage of brain was investigated with a special microscopic examination that detected early neural injury. Brain damage caused by the selective cerebral perfusion was more serious in juvenile rats bred under hypoxic environment than in normal rats. So, we should be careful about the selective cerebral perfusion of children with cyanosis.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2006 -2007 
    Author : TAKEDA Yutaka; MISHIMA Akira; OHTE Nobuyuki; ASANO Miki; DOHI Yasuaki; MIZUNO Kantaro
     
    We enrolled 20 patients with congenital heart disease who are 15 years ole and older to this investigation. NYHAfunctional class were2.4±0.6, and exercise tolerance defined with Specific Activity Scale questionnaire was 5.1±1.3 METs. Univariate regression analyses found that plasma concentrations of endothelin-1(standardized correlation coefficient [β]=-0.446,P=0.049), uninary norepinephrine concentraion (β=-0.536, P=0.015), and urinary biopyrrin concentration (β=-0.535, P=0.015) were inversely correlated with exercise capacity. There was a trend that exercise capacity of the patients with SpO2 <90% were less than that of those with 90% or more (β=0.396, 1:=0.084). Unexpectedly, strong positive correlation was found between exercise capacity and plasma concentration of brain natriuretic peptide. A multivariate regression analysis with forward stepwise selection of variable found that presence of hypoxia (β=-0.439, P=0.023) and urinary concentration of norepinephrine (β=-0.569, P=0.005) were independent predictors of exercise tolerance. A strong positive correlation was noted between urinary norepinephrine and biopyrrin (β=0.806, F<0.001). This study demonstrated that urinary levels of norepinephrine and biopyrrin and plasma level of endothelin-1 but not that of brain natriuretic peptide were available for marker of severity of congenital heart disease in adult patients. The strong correlation in urinary levels between norepinephrine and biopyrrin suggests antioxidation and sympatholysis are potential approach to management of patients with adult congenital heart disease.
  • 日本学術振興会：科学研究費助成事業
    Date (from‐to) : 2002 -2003 
    Author : 三島 晃; 浅野 實樹
     
    【方法】4週齢雄Wistarラットをnormoxia群(n=12)、CT-1+normoxia群(n=11)、hypoxia群(n-12)、CT-1+hypoxia群(n=10)の4群に分けた。normoxiaの2群は室内空気環境下で、hypoxiaの2群はO_210%環境下で9日間飼育した。同期間にCT-1投与の2群にはmouse recombinant CT-1 50μg/kgを、他の2群には同量のリン酸バッファー液を1日1回腹腔内投与した。(i)10日目に肺動脈リングを採取しnorepinephrineで収縮後にacetylcholine(ACh)またはsodium nitroprusside(SNP)を加え、AChまたはSNP各濃度(10^<-9>〜10^<-5>M)における内皮依存性および非依存性の血管弛緩能(%relaxation)を比較検討した。(ii)摘出した肺をホルマリン固定し、Hematoxylin-Eosin染色とElastica-Masson染色した組織標本で肺動脈中膜肥厚を評価した。 【結果】(i)AChによる%relaxation(normoxia群、CT-1+normoxia群、hypoxia群、CT-1+hypoxia群)はACh10^<-5>Mでそれぞれ59.5±17.4、52.8±15.5、17.4±4.8、42.3±14.8%であり、CT-1+hypoxia群ではhypoxia群と比べ内皮依存性血管弛緩反応の障害が軽減された(P<0.01)。SNPによる%relaxationではCT-1+hypoxia群とhypoxia群の間に差はなく、CT-1は内皮非依存性血管弛緩反応に影響を与えなかった。(ii)径200-1000μmの肺動脈ではCT-1+hypoxia群、hypoxia群とも中膜肥厚は著明でCT-1投与による差はなかった。 【総括】CT-1は内皮依存性血管弛緩反応の障害を軽減させた。前年度の研究でCT-1が肺動脈圧の上昇を抑制することを明らかにしているが、このメカニズムにCT-1の内皮依存性血管弛緩反応障害軽減作用が関与すると考えられた。CT-1は肺高血圧の治療に有効であると考えられた。
  • 心移植および異種移植における免疫寛容誘導
  • 心筋および肺血管床における虚血再還流障害

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