KAWAUCHI Daisuke

Researcher Information

Degree

• Ph. D（2004/03 Osaka University）

J-Global ID

• 200901028875684272

Research Interests

• cancer epigenetics   Brain microenvironment   上衣腫   ゲノム編集   oncogene   Electroporation   Pediatric brain tumor   cancer stem cell   cerebellum   medulloblastoma   neuronal differentiation   

Research Areas

• Life sciences / Tumor biology
• Life sciences / Developmental biology
• Life sciences / Neuroscience - general / Neuro-oncology

Academic & Professional Experience

• 2024/04 - Today  Nagoya City UniversityGraduate School of Medical Sciences, Institute of Brain Science, Department of Neuro-oncologyProfessor
• 2023/04 - 2024/03  Graduate School of Medicine, Science and Technology, Shinshu University総合医理工学研究科Specially appointed associate professor
• 2019/12 - 2024/03  National Center of Neurology and Psychiatry病態生化学研究部/細胞生化学研究室室長
• 2018/08 - 2019/11  ドイツ癌研究センター小児脳腫瘍学テニュアグループリーダー
• 2013/05 - 2018/07  ドイツ癌研究センター小児脳腫瘍学テニュアトラック・グループリーダー
• 2009/05 - 2013/04  St Jude Children's Research HospitalPostdoctral fellow
• 2005/05 - 2009/04  Chiba UniversityGraduate School of Medicine助教
• 2004/04 - 2005/04  Osaka UniversityGraduate School of Frontier Biosciences博士研究員

Education

• 1999 - 2004  Osaka University  基礎工学研究科  システム人間系生物工学分野
• 1995 - 1999  Osaka University  School of Science  物理系宇宙地球科学科

Association Memberships

• 日本分子生物学会   日本癌学会   日本神経科学学会   米国癌学会   

Published Papers

• Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression

  Ryo Shiraishi; Gabriele Cancila; Kohei Kumegawa; Jacob Torrejon; Irene Basili; Flavia Bernardi; Patricia Benites Goncalves da Silva; Wanchen Wang; Owen Chapman; Liying Yang; Maki Jami; Kayo Nishitani; Yukimi Arai; Zhize Xiao; Hua Yu; Valentina Lo Re; Véronique Marsaud; Julie Talbot; Bérangère Lombard; Damarys Loew; Maho Jingu; Konstantin Okonechnikov; Masaki Sone; Norio Motohashi; Yoshitsugu Aoki; Stefan M. Pfister; Lukas Chavez; Mikio Hoshino; Reo Maruyama; Olivier Ayrault; Daisuke Kawauchi

  Developmental Cell Elsevier BV 1534-5807 2024/06 [Refereed]
  
• Compartments in medulloblastoma with extensive nodularity are connected through differentiation along the granular precursor lineage.

  David R Ghasemi; Konstantin Okonechnikov; Anne Rademacher; Stephan Tirier; Kendra K Maass; Hanna Schumacher; Piyush Joshi; Maxwell P Gold; Julia Sundheimer; Britta Statz; Ahmet S Rifaioglu; Katharina Bauer; Sabrina Schumacher; Michele Bortolomeazzi; Felice Giangaspero; Kati J Ernst; Steven C Clifford; Julio Saez-Rodriguez; David T W Jones; Daisuke Kawauchi; Ernest Fraenkel; Jan-Philipp Mallm; Karsten Rippe; Andrey Korshunov; Stefan M Pfister; Kristian W Pajtler

  Nature communications 15 (1) 269 - 269 2024/01 [Refereed]
  
• Mapping pediatric brain tumors to their origins in the developing cerebellum.

  Konstantin Okonechnikov; Piyush Joshi; Mari Sepp; Kevin Leiss; Ioannis Sarropoulos; Florent Murat; Martin Sill; Pengbo Beck; Kenneth Chun-Ho Chan; Andrey Korshunov; Felix Sah; Maximilian Y Deng; Dominik Sturm; John DeSisto; Andrew M Donson; Nicholas K Foreman; Adam L Green; Giles Robinson; Brent A Orr; Qingsong Gao; Emily Darrow; Jennifer L Hadley; Paul A Northcott; Johannes Gojo; Daisuke Kawauchi; Volker Hovestadt; Mariella G Filbin; Andreas von Deimling; Marc Zuckermann; Kristian W Pajtler; Marcel Kool; David T W Jones; Natalie Jäger; Lena M Kutscher; Henrik Kaessmann; Stefan M Pfister

  Neuro-oncology 25 (10) 1895 - 1909 2023/10 [Refereed]
  
• Ligand Installation to Polymeric Micelles for Pediatric Brain Tumor Targeting.

  Takayoshi Watanabe; Hayato Laurence Mizuno; Jumpei Norimatsu; Takumi Obara; Horacio Cabral; Kouhei Tsumoto; Makoto Nakakido; Daisuke Kawauchi; Yasutaka Anraku

  Polymers 15 (7) 2023/04 [Refereed]
  
• Primary cilia control translation and the cell cycle in medulloblastoma.

  Yong Ha Youn; Shirui Hou; Chang-Chih Wu; Daisuke Kawauchi; Brent A Orr; Giles W Robinson; David Finkelstein; Makoto M Taketo; Richard J Gilbertson; Martine F Roussel; Young-Goo Han

  Genes & development 36 (11-12) 737 - 751 2022/06 [Refereed]
  
• Editorial: Molecular characteristics and personalized treatment for pediatric brain tumors.

  Weijun Feng; Daisuke Kawauchi; Feng Wan

  Frontiers in oncology 12 1114280 - 1114280 2022 [Refereed][Invited]
  
• Sonic Hedgehog Signaling in Cerebellar Development and Cancer.

  Wanchen Wang; Ryo Shiraishi; Daisuke Kawauchi

  Frontiers in cell and developmental biology 10 864035 - 864035 2022 [Refereed][Invited]
  
• T-cell Receptor Therapy Targeting Mutant Capicua Transcriptional Repressor in Experimental Gliomas.

  Michael Kilian; Mirco Friedrich; Khwab Sanghvi; Edward Green; Stefan Pusch; Daisuke Kawauchi; Martin Löwer; Jana K Sonner; Christopher Krämer; Julia Zaman; Stefanie Jung; Michael O Breckwoldt; Gerald Willimksy; Stefan B Eichmüller; Andreas von Deimling; Wolfgang Wick; Felix Sahm; Michael Platten; Lukas Bunse

  Clinical cancer research : an official journal of the American Association for Cancer Research 2021/11 [Refereed]
  
• Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models.

  Ryo Shiraishi; Daisuke Kawauchi

  Cancer science 112 (8) 2948 - 2957 2021/05 [Refereed][Invited]
  
• Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas.

  Tuyu Zheng; David R Ghasemi; Konstantin Okonechnikov; Andrey Korshunov; Martin Sill; Kendra K Maass; Patricia Benites Goncalves da Silva; Marina Ryzhova; Johannes Gojo; Damian Stichel; Amir Arabzade; Robert Kupp; Julia Benzel; Shinichiro Taya; Toma Adachi; Ryo Shiraishi; Nicolas U Gerber; Dominik Sturm; Jonas Ecker; Philipp Sievers; Florian Selt; Rebecca Chapman; Christine Haberler; Dominique Figarella-Branger; Guido Reifenberger; Gudrun Fleischhack; Stefan Rutkowski; Andrew M Donson; Vijay Ramaswamy; David Capper; David W Ellison; Christel C Herold-Mende; Ulrich Schuller; Sebastian Brandner; Pablo Hernaiz Driever; Johan M Kros; Matija Snuderl; Till Milde; Richard G Grundy; Mikio Hoshino; Stephen C Mack; Richard J Gilbertson; David T W Jones; Marcel Kool; Andreas von Deimling; Stefan M Pfister; Felix Sahm; Daisuke Kawauchi; Kristian W Pajtler

  Cancer discovery 11 (9) 2230 - 2247 2021/04 [Refereed]
  
• Notch Signaling between Cerebellar Granule Cell Progenitors.

  Toma Adachi; Satoshi Miyashita; Mariko Yamashita; Mana Shimoda; Konstantin Okonechnikov; Lukas Chavez; Marcel Kool; Stefan M Pfister; Takafumi Inoue; Daisuke Kawauchi; Mikio Hoshino

  eNeuro 8 (3) 2021/03 [Refereed]
  
• ZFTA-RELA Dictates Oncogenic Transcriptional Programs to Drive Aggressive Supratentorial Ependymoma.

  Amir Arabzade; Yanhua Zhao; Srinidhi Varadharajan; Hsiao-Chi Chen; Selin Jessa; Bryan Rivas; Austin J Stuckert; Minerva Solis; Alisha Kardian; Dana Tlais; Brian J Golbourn; Ann-Catherine J Stanton; Yuen San Chan; Calla Olson; Kristen L Karlin; Kathleen Kong; Robert Kupp; Baoli Hu; Sarah G Injac; Madeline Ngo; Peter R Wang; Luz A De Leon; Felix Sahm; Daisuke Kawauchi; Stefan M Pfister; Charles Y Lin; H Courtney Hodges; Irtisha Singh; Thomas F Westbrook; Murali M Chintagumpala; Susan M Blaney; Donald W Parsons; Kristian W Pajtler; Sameer Agnihotri; Richard J Gilbertson; Joanna Yi; Nada Jabado; Claudia L Kleinman; Kelsey C Bertrand; Benjamin Deneen; Stephen C Mack

  Cancer discovery 2021/03 [Refereed]
  
• ZFTA-translocations constitute ependymoma chromatin remodeling and transcription factors.

  Robert Kupp; Lisa Ruff; Sabrina Terranova; Erica Nathan; Stephane Ballereau; Rory Stark; Chandra Sekhar Reddy Chilamakuri; Nadin Hoffmann; Katherine Wickham-Rahrmann; Marcus Widdess; Amir Arabzade; Yanhua Zhao; Srinidhi Varadharajan; Tuyu Zheng; Mohankumar K Murugesan; Stefan M Pfister; Daisuke Kawauchi; Kristian W Pajtler; Benjamin Deneen; Stephen C Mack; Katherine E Masih; Berkley E Gryder; Javed Khan; Richard J Gilbertson

  Cancer discovery 2021/03 [Refereed]
  
• H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.

  Daniel Haag; Norman Mack; Patricia Benites Goncalves da Silva; Britta Statz; Jessica Clark; Koji Tanabe; Tanvi Sharma; Natalie Jäger; David T W Jones; Daisuke Kawauchi; Marius Wernig; Stefan M Pfister

  Cancer cell 39 (3) 407 - 422 2021/03 [Refereed]
  
• Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation.

  Lena M Kutscher; Konstantin Okonechnikov; Nadja V Batora; Jessica Clark; Patricia B G Silva; Mikaella Vouri; Sjoerd van Rijn; Laura Sieber; Britta Statz; Micah D Gearhart; Ryo Shiraishi; Norman Mack; Brent A Orr; Andrey Korshunov; Brian L Gudenas; Kyle S Smith; Audrey L Mercier; Olivier Ayrault; Mikio Hoshino; Marcel Kool; Katja von Hoff; Norbert Graf; Gudrun Fleishhack; Vivian J Bardwell; Stefan M Pfister; Paul A Northcott; Daisuke Kawauchi

  Genes & development 2020/08 [Refereed]
  
• Comparison of tumor-associated YAP1 fusions identifies a recurrent set of functions critical for oncogenesis.

  Frank Szulzewsky; Sonali Arora; Pia Hoellerbauer; Claire King; Erica Nathan; Marina Chan; Patrick J Cimino; Tatsuya Ozawa; Daisuke Kawauchi; Kristian W Pajtler; Richard J Gilbertson; Patrick J Paddison; Valeri Vasioukhin; Taranjit S Gujral; Eric C Holland

  Genes & development 34 (15-16) 1051 - 1064 2020/08 [Refereed]
  
• MYCN amplification drives an aggressive form of spinal ependymoma.

  David R Ghasemi; Martin Sill; Konstantin Okonechnikov; Andrey Korshunov; Stephen Yip; Peter W Schutz; David Scheie; Anders Kruse; Patrick N Harter; Marina Kastelan; Marlies Wagner; Christian Hartmann; Julia Benzel; Kendra K Maass; Mustafa Khasraw; Ronald Sträter; Christian Thomas; Werner Paulus; Christian P Kratz; Hendrik Witt; Daisuke Kawauchi; Christel Herold-Mende; Felix Sahm; Sebastian Brandner; Marcel Kool; David T W Jones; Andreas von Deimling; Stefan M Pfister; David E Reuss; Kristian W Pajtler

  Acta neuropathologica 138 (6) 1075 - 1089 0001-6322 2019/12 [Refereed]
  
• YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.

  Kristian W Pajtler; Yiju Wei; Konstantin Okonechnikov; Patricia B G Silva; Mikaella Vouri; Lei Zhang; Sebastian Brabetz; Laura Sieber; Melissa Gulley; Monika Mauermann; Tatjana Wedig; Norman Mack; Yuka Imamura Kawasawa; Tanvi Sharma; Marc Zuckermann; Felipe Andreiuolo; Eric Holland; Kendra Maass; Huiqin Körkel-Qu; Hai-Kun Liu; Felix Sahm; David Capper; Jens Bunt; Linda J Richards; David T W Jones; Andrey Korshunov; Lukas Chavez; Peter Lichter; Mikio Hoshino; Stefan M Pfister; Marcel Kool; Wei Li; Daisuke Kawauchi

  Nature communications 10 (1) 3914 - 3914 2019/09 [Refereed]
  
• Aberrant ERBB4-SRC Signaling as a Hallmark of Group 4 Medulloblastoma Revealed by Integrative Phosphoproteomic Profiling.

  Antoine Forget; Loredana Martignetti; Stéphanie Puget; Laurence Calzone; Sebastian Brabetz; Daniel Picard; Arnau Montagud; Stéphane Liva; Alexandre Sta; Florent Dingli; Guillaume Arras; Jaime Rivera; Damarys Loew; Aurore Besnard; Joëlle Lacombe; Mélanie Pagès; Pascale Varlet; Christelle Dufour; Hua Yu; Audrey L Mercier; Emilie Indersie; Anaïs Chivet; Sophie Leboucher; Laura Sieber; Kevin Beccaria; Michael Gombert; Frauke D Meyer; Nan Qin; Jasmin Bartl; Lukas Chavez; Konstantin Okonechnikov; Tanvi Sharma; Venu Thatikonda; Franck Bourdeaut; Celio Pouponnot; Vijay Ramaswamy; Andrey Korshunov; Arndt Borkhardt; Guido Reifenberger; Patrick Poullet; Michael D Taylor; Marcel Kool; Stefan M Pfister; Daisuke Kawauchi; Emmanuel Barillot; Marc Remke; Olivier Ayrault

  Cancer cell 34 (3) 379 - 395 1535-6108 2018/09 [Refereed]
  
• CRISPR-mediated Loss of Function Analysis in Cerebellar Granule Cells Using In Utero Electroporation-based Gene Transfer.

  Weijun Feng; Lena Herbst; Peter Lichter; Stefan M Pfister; Hai-Kun Liu; Daisuke Kawauchi

  Journal of visualized experiments : JoVE (136) 2018/06 [Refereed]
  
• CRISPR-engineered genome editing for the next generation neurological disease modeling.

  Weijun Feng; Hai-Kun Liu; Daisuke Kawauchi

  Progress in neuro-psychopharmacology & biological psychiatry PERGAMON-ELSEVIER SCIENCE LTD 81 459 - 467 0278-5846 2018/02 [Refereed]
  
• Novel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells

  D. Kawauchi; R. J. Ogg; L. Liu; D. J. H. Shih; D. Finkelstein; B. L. Murphy; J. E. Rehg; A. Korshunov; C. Calabrese; F. Zindy; T. Phoenix; Y. Kawaguchi; J. Gronych; R. J. Gilbertson; P. Lichter; A. Gajjar; M. Kool; P. A. Northcott; S. M. Pfister; M. F. Roussel

  ONCOGENE NATURE PUBLISHING GROUP 36 (37) 5231 - 5242 0950-9232 2017/09 [Refereed]
  
• Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme.

  Weijun Feng; Daisuke Kawauchi; Huiqin Körkel-Qu; Huan Deng; Elisabeth Serger; Laura Sieber; Jenna Ariel Lieberman; Silvia Jimeno-González; Sander Lambo; Bola S Hanna; Yassin Harim; Malin Jansen; Anna Neuerburg; Olga Friesen; Marc Zuckermann; Vijayanad Rajendran; Jan Gronych; Olivier Ayrault; Andrey Korshunov; David T W Jones; Marcel Kool; Paul A Northcott; Peter Lichter; Felipe Cortés-Ledesma; Stefan M Pfister; Hai-Kun Liu

  Nature communications NATURE PUBLISHING GROUP 8 14758 - 14758 2041-1723 2017/03 [Refereed]
  
• Applications of the CRISPR/Cas9 system in murine cancer modeling

  Marc Zuckermann; Daisuke Kawauchi; Jan Gronych

  BRIEFINGS IN FUNCTIONAL GENOMICS OXFORD UNIV PRESS 16 (1) 25 - 33 2041-2649 2017/01 [Refereed]
  
• FBW7 suppression leads to SOX9 stabilization and increased malignancy in medulloblastoma.

  Aldwin Suryo Rahmanto; Vasil Savov; Andrä Brunner; Sara Bolin; Holger Weishaupt; Alena Malyukova; Gabriela Rosén; Matko Čančer; Sonja Hutter; Anders Sundström; Daisuke Kawauchi; David Tw Jones; Charles Spruck; Michael D Taylor; Yoon-Jae Cho; Stefan M Pfister; Marcel Kool; Andrey Korshunov; Fredrik J Swartling; Olle Sangfelt

  The EMBO journal WILEY-BLACKWELL 35 (20) 2192 - 2212 0261-4189 2016/10 [Refereed]
  
• Active medulloblastoma enhancers reveal subgroup-specific cellular origins.

  Charles Y Lin; Serap Erkek; Yiai Tong; Linlin Yin; Alexander J Federation; Marc Zapatka; Parthiv Haldipur; Daisuke Kawauchi; Thomas Risch; Hans-Jörg Warnatz; Barbara C Worst; Bensheng Ju; Brent A Orr; Rhamy Zeid; Donald R Polaski; Maia Segura-Wang; Sebastian M Waszak; David T W Jones; Marcel Kool; Volker Hovestadt; Ivo Buchhalter; Laura Sieber; Pascal Johann; Lukas Chavez; Stefan Gröschel; Marina Ryzhova; Andrey Korshunov; Wenbiao Chen; Victor V Chizhikov; Kathleen J Millen; Vyacheslav Amstislavskiy; Hans Lehrach; Marie-Laure Yaspo; Roland Eils; Peter Lichter; Jan O Korbel; Stefan M Pfister; James E Bradner; Paul A Northcott

  Nature NATURE PUBLISHING GROUP 530 (7588) 57 - 62 0028-0836 2016/02 [Refereed]
  
• The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.

  BaoHan T Vo; Elmar Wolf; Daisuke Kawauchi; Anneli Gebhardt; Jerold E Rehg; David Finkelstein; Susanne Walz; Brian L Murphy; Yong Ha Youn; Young-Goo Han; Martin Eilers; Martine F Roussel

  Cancer cell CELL PRESS 29 (1) 5 - 16 1535-6108 2016/01 [Refereed]
  
• TNF Counterbalances the Emergence of M2 Tumor Macrophages.

  Franz Kratochvill; Geoffrey Neale; Jessica M Haverkamp; Lee-Ann Van de Velde; Amber M Smith; Daisuke Kawauchi; Justina McEvoy; Martine F Roussel; Michael A Dyer; Joseph E Qualls; Peter J Murray

  Cell reports CELL PRESS 12 (11) 1902 - 14 2211-1247 2015/09 [Refereed]
  
• ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy.

  Marie Morfouace; Satish Cheepala; Sadhana Jackson; Yu Fukuda; Yogesh T Patel; Soghra Fatima; Daisuke Kawauchi; Anang A Shelat; Clinton F Stewart; Brian P Sorrentino; John D Schuetz; Martine F Roussel

  Cancer research AMER ASSOC CANCER RESEARCH 75 (18) 3879 - 89 0008-5472 2015/09 [Refereed]
  
• Cross-species epigenetics identifies a critical role for VAV1 in SHH subgroup medulloblastoma maintenance

  J. C. Lindsey; D. Kawauchi; E. C. Schwalbe; D. J. Solecki; M. P. Selby; P. J. McKinnon; J. M. Olson; J. T. Hayden; R. G. Grundy; D. W. Ellison; D. Williamson; S. Bailey; M. F. Roussel; S. C. Clifford

  ONCOGENE NATURE PUBLISHING GROUP 34 (36) 4746 - 4757 0950-9232 2015/09 [Refereed]
  
• "CRISPR" validation of recessive brain cancer genes in vivo.

  Marc Zuckermann; Daisuke Kawauchi; Jan Gronych

  Oncotarget IMPACT JOURNALS LLC 6 (20) 17865 - 6 1949-2553 2015/07 [Refereed]
  
• Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling.

  Marc Zuckermann; Volker Hovestadt; Christiane B Knobbe-Thomsen; Marc Zapatka; Paul A Northcott; Kathrin Schramm; Jelena Belic; David T W Jones; Barbara Tschida; Branden Moriarity; David Largaespada; Martine F Roussel; Andrey Korshunov; Guido Reifenberger; Stefan M Pfister; Peter Lichter; Daisuke Kawauchi; Jan Gronych

  Nature communications NATURE PUBLISHING GROUP 6 7391 - 7391 2041-1723 2015/06 [Refereed]
  
• Casein kinase 1δ is an APC/C(Cdh1) substrate that regulates cerebellar granule cell neurogenesis.

  Clara Penas; Eve-Ellen Govek; Yin Fang; Vimal Ramachandran; Mark Daniel; Weiping Wang; Marie E Maloof; Ronald J Rahaim; Mathieu Bibian; Daisuke Kawauchi; David Finkelstein; Jeng-Liang Han; Jun Long; Bin Li; David J Robbins; Marcos Malumbres; Martine F Roussel; William R Roush; Mary E Hatten; Nagi G Ayad

  Cell reports CELL PRESS 11 (2) 249 - 60 2211-1247 2015/04 [Refereed]
  
• Calm1 signaling pathway is essential for the migration of mouse precerebellar neurons.

  Hiroaki Kobayashi; Shunsuke Saragai; Atsushi Naito; Koji Ichio; Daisuke Kawauchi; Fujio Murakami

  Development (Cambridge, England) COMPANY OF BIOLOGISTS LTD 142 (2) 375 - 84 0950-1991 2015/01 [Refereed]
  
• Dicer Is Required for Normal Cerebellar Development and to Restrain Medulloblastoma Formation.

  Frederique Zindy; Youngsoo Lee; Daisuke Kawauchi; Olivier Ayrault; Leila Ben Merzoug; Yang Li; Peter J McKinnon; Martine F Roussel

  PloS one PUBLIC LIBRARY SCIENCE 10 (6) e0129642  1932-6203 2015 [Refereed]
  
• Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma.

  Paul A Northcott; Catherine Lee; Thomas Zichner; Adrian M Stütz; Serap Erkek; Daisuke Kawauchi; David J H Shih; Volker Hovestadt; Marc Zapatka; Dominik Sturm; David T W Jones; Marcel Kool; Marc Remke; Florence M G Cavalli; Scott Zuyderduyn; Gary D Bader; Scott VandenBerg; Lourdes Adriana Esparza; Marina Ryzhova; Wei Wang; Andrea Wittmann; Sebastian Stark; Laura Sieber; Huriye Seker-Cin; Linda Linke; Fabian Kratochwil; Natalie Jäger; Ivo Buchhalter; Charles D Imbusch; Gideon Zipprich; Benjamin Raeder; Sabine Schmidt; Nicolle Diessl; Stephan Wolf; Stefan Wiemann; Benedikt Brors; Chris Lawerenz; Jürgen Eils; Hans-Jörg Warnatz; Thomas Risch; Marie-Laure Yaspo; Ursula D Weber; Cynthia C Bartholomae; Christof von Kalle; Eszter Turányi; Peter Hauser; Emma Sanden; Anna Darabi; Peter Siesjö; Jaroslav Sterba; Karel Zitterbart; David Sumerauer; Peter van Sluis; Rogier Versteeg; Richard Volckmann; Jan Koster; Martin U Schuhmann; Martin Ebinger; H Leighton Grimes; Giles W Robinson; Amar Gajjar; Martin Mynarek; Katja von Hoff; Stefan Rutkowski; Torsten Pietsch; Wolfram Scheurlen; Jörg Felsberg; Guido Reifenberger; Andreas E Kulozik; Andreas von Deimling; Olaf Witt; Roland Eils; Richard J Gilbertson; Andrey Korshunov; Michael D Taylor; Peter Lichter; Jan O Korbel; Robert J Wechsler-Reya; Stefan M Pfister

  Nature NATURE PUBLISHING GROUP 511 (7510) 428 - 34 0028-0836 2014/07 [Refereed]
  
• Genomic and transcriptomic analyses match medulloblastoma mouse models to their human counterparts.

  Julia Pöschl; Sebastian Stark; Philipp Neumann; Susanne Gröbner; Daisuke Kawauchi; David T W Jones; Paul A Northcott; Peter Lichter; Stefan M Pfister; Marcel Kool; Ulrich Schüller

  Acta neuropathologica SPRINGER 128 (1) 123 - 36 0001-6322 2014/07 [Refereed]
  
• Role of the miR-17∼92 cluster family in cerebellar and medulloblastoma development.

  Frederique Zindy; Daisuke Kawauchi; Youngsoo Lee; Olivier Ayrault; Leila Ben Merzoug; Peter J McKinnon; Andrea Ventura; Martine F Roussel

  Biology open COMPANY OF BIOLOGISTS LTD 3 (7) 597 - 605 2046-6390 2014/06 [Refereed]
  
• THE CONTROL OF PRECEREBELLAR NEURON MIGRATION BY RNA-BINDING PROTEIN CSDE1

  H. Kobayashi; D. Kawauchi; Y. Hashimoto; T. Ogata; F. Murakami

  NEUROSCIENCE PERGAMON-ELSEVIER SCIENCE LTD 253 292 - 303 0306-4522 2013/12 [Refereed]
  
• Miz1 is required to maintain autophagic flux.

  Elmar Wolf; Anneli Gebhardt; Daisuke Kawauchi; Susanne Walz; Björn von Eyss; Nicole Wagner; Christoph Renninger; Georg Krohne; Esther Asan; Martine F Roussel; Martin Eilers

  Nature communications NATURE PUBLISHING GROUP 4 2535 - 2535 2041-1723 2013 [Refereed]
  
• Subgroup-specific structural variation across 1,000 medulloblastoma genomes.

  Paul A Northcott; David J H Shih; John Peacock; Livia Garzia; A Sorana Morrissy; Thomas Zichner; Adrian M Stütz; Andrey Korshunov; Jüri Reimand; Steven E Schumacher; Rameen Beroukhim; David W Ellison; Christian R Marshall; Anath C Lionel; Stephen Mack; Adrian Dubuc; Yuan Yao; Vijay Ramaswamy; Betty Luu; Adi Rolider; Florence M G Cavalli; Xin Wang; Marc Remke; Xiaochong Wu; Readman Y B Chiu; Andy Chu; Eric Chuah; Richard D Corbett; Gemma R Hoad; Shaun D Jackman; Yisu Li; Allan Lo; Karen L Mungall; Ka Ming Nip; Jenny Q Qian; Anthony G J Raymond; Nina T Thiessen; Richard J Varhol; Inanc Birol; Richard A Moore; Andrew J Mungall; Robert Holt; Daisuke Kawauchi; Martine F Roussel; Marcel Kool; David T W Jones; Hendrick Witt; Africa Fernandez-L; Anna M Kenney; Robert J Wechsler-Reya; Peter Dirks; Tzvi Aviv; Wieslawa A Grajkowska; Marta Perek-Polnik; Christine C Haberler; Olivier Delattre; Stéphanie S Reynaud; François F Doz; Sarah S Pernet-Fattet; Byung-Kyu Cho; Seung-Ki Kim; Kyu-Chang Wang; Wolfram Scheurlen; Charles G Eberhart; Michelle Fèvre-Montange; Anne Jouvet; Ian F Pollack; Xing Fan; Karin M Muraszko; G Yancey Gillespie; Concezio Di Rocco; Luca Massimi; Erna M C Michiels; Nanne K Kloosterhof; Pim J French; Johan M Kros; James M Olson; Richard G Ellenbogen; Karel Zitterbart; Leos Kren; Reid C Thompson; Michael K Cooper; Boleslaw Lach; Roger E McLendon; Darell D Bigner; Adam Fontebasso; Steffen Albrecht; Nada Jabado; Janet C Lindsey; Simon Bailey; Nalin Gupta; William A Weiss; László Bognár; Almos Klekner; Timothy E Van Meter; Toshihiro Kumabe; Teiji Tominaga; Samer K Elbabaa; Jeffrey R Leonard; Joshua B Rubin; Linda M Liau; Erwin G Van Meir; Maryam Fouladi; Hideo Nakamura; Giuseppe Cinalli; Miklós Garami; Peter Hauser; Ali G Saad; Achille Iolascon; Shin Jung; Carlos G Carlotti; Rajeev Vibhakar; Young Shin Ra; Shenandoah Robinson; Massimo Zollo; Claudia C Faria; Jennifer A Chan; Michael L Levy; Poul H B Sorensen; Matthew Meyerson; Scott L Pomeroy; Yoon-Jae Cho; Gary D Bader; Uri Tabori; Cynthia E Hawkins; Eric Bouffet; Stephen W Scherer; James T Rutka; David Malkin; Steven C Clifford; Steven J M Jones; Jan O Korbel; Stefan M Pfister; Marco A Marra; Michael D Taylor

  Nature NATURE PUBLISHING GROUP 488 (7409) 49 - 56 0028-0836 2012/08 [Refereed]
  
• Novel mutations target distinct subgroups of medulloblastoma.

  Giles Robinson; Matthew Parker; Tanya A Kranenburg; Charles Lu; Xiang Chen; Li Ding; Timothy N Phoenix; Erin Hedlund; Lei Wei; Xiaoyan Zhu; Nader Chalhoub; Suzanne J Baker; Robert Huether; Richard Kriwacki; Natasha Curley; Radhika Thiruvenkatam; Jianmin Wang; Gang Wu; Michael Rusch; Xin Hong; Jared Becksfort; Pankaj Gupta; Jing Ma; John Easton; Bhavin Vadodaria; Arzu Onar-Thomas; Tong Lin; Shaoyi Li; Stanley Pounds; Steven Paugh; David Zhao; Daisuke Kawauchi; Martine F Roussel; David Finkelstein; David W Ellison; Ching C Lau; Eric Bouffet; Tim Hassall; Sridharan Gururangan; Richard Cohn; Robert S Fulton; Lucinda L Fulton; David J Dooling; Kerri Ochoa; Amar Gajjar; Elaine R Mardis; Richard K Wilson; James R Downing; Jinghui Zhang; Richard J Gilbertson

  Nature NATURE PUBLISHING GROUP 488 (7409) 43 - 8 0028-0836 2012/08 [Refereed]
  
• A mouse model of the most aggressive subgroup of human medulloblastoma.

  Daisuke Kawauchi; Giles Robinson; Tamar Uziel; Paul Gibson; Jerold Rehg; Cuilan Gao; David Finkelstein; Chunxu Qu; Stanley Pounds; David W Ellison; Richard J Gilbertson; Martine F Roussel

  Cancer cell CELL PRESS 21 (2) 168 - 80 1535-6108 2012/02 [Refereed]
  
• Expression of major guidance receptors is differentially regulated in spinal commissural neurons transfated by mammalian Barh genes.

  Daisuke Kawauchi; Yuko Muroyama; Tatsuya Sato; Tetsuichiro Saito

  Developmental biology ACADEMIC PRESS INC ELSEVIER SCIENCE 344 (2) 1026 - 34 0012-1606 2010/08 [Refereed]
  
• Transcriptional cascade from Math1 to Mbh1 and Mbh2 is required for cerebellar granule cell differentiation.

  Daisuke Kawauchi; Tetsuichiro Saito

  Developmental biology ACADEMIC PRESS INC ELSEVIER SCIENCE 322 (2) 345 - 54 0012-1606 2008/10 [Refereed]
  
• Classic cadherins regulate tangential migration of precerebellar neurons in the caudal hindbrain.

  Hiroki Taniguchi; Daisuke Kawauchi; Kazuhiko Nishida; Fujio Murakami

  Development (Cambridge, England) COMPANY OF BIOLOGISTS LTD 133 (10) 1923 - 31 0950-1991 2006/05 [Refereed]
  
• Direct visualization of nucleogenesis by precerebellar neurons: involvement of ventricle-directed, radial fibre-associated migration.

  Daisuke Kawauchi; Hiroki Taniguchi; Haruyasu Watanabe; Tetsuichiro Saito; Fujio Murakami

  Development (Cambridge, England) COMPANY OF BIOLOGISTS LTD 133 (6) 1113 - 23 0950-1991 2006/03 [Refereed]
  
• MuSC is involved in regulating axonal fasciculation of mouse primary vestibular afferents.

  Daisuke Kawauchi; Hiroaki Kobayashi; Yoko Sekine-Aizawa; Shinobu C Fujita; Fujio Murakami

  The European journal of neuroscience BLACKWELL PUBLISHING LTD 18 (8) 2244 - 52 0953-816X 2003/10 [Refereed]
  

Books etc

• 疾患原因遺伝子・タンパク質の解析技術と創薬/診断技術への応用

  白石椋; 川内大輔 (Joint work個別化治療を目指した小児脳腫瘍の分子遺伝学的診断と腫瘍増殖メカニズム)技術情報協会 2022/03 9784861048777

Conference Activities & Talks

• Dynamic chromatin alteration causes oncogenic hijacking by NFIA/B during medulloblastoma tumorigenesis  [Invited]

  Ryo Shiraishi; Gabriele Cancila; Kohei Kumegawa; Reo Maruyama; Olivier Ayraul; Daisuke Kawauchi

  The 82nd Annual Meeting of the Japanese Cancer Association  2023/09
• Conditional expression and activation of DREADDs reveals novel impact of neuron-tumor communications on brain tumor progression.  [Not invited]

  Daisuke Kawauchi; Naofumi Uesaka

  1st Heidelberg Conference on Cancer Neuroscience  2023/07
• Discovery of Novel Oncogenic Signaling for Pediatric Brain Tumors via Understanding of Human Cancer Genomes  [Invited]

  Daisuke Kawauchi

  The 9th US-JAPAN Conference on Oncology  2022/06
• Discovery and Understanding of Oncogenic Fusion Genes in Ependymoma  [Invited]

  Daisuke Kawauchi

  第6回世界連邦脳腫瘍学会  2022/03
• Epigenetic regulation of SHH subgroup medulloblastoma formation  [Invited]

  Daisuke Kawauchi

  第44回日本神経科学学会  2021/07
• Future Prospective in preclinical studies of pediatric brain tumors using mouse molecular genetic technologies  [Invited]

  Daisuke Kawauchi

  ISPNO2020  2020/12
• C11orf95 rearrangements dictate oncogenic dependence in supratentorial brain tumors  [Invited]

  Daisuke Kawauchi

  第79回日本癌学会  2020/10
• A mouse model of the most aggressive subgroup of human medulloblastoma  [Not invited]

  川内 大輔

  2012 AACR annual meeting  2012/03
• A mouse model of the most aggressive subgroup of human medulloblastoma  [Not invited]

  KAWAUCHI Daisuke

  2012 AACR annual meeting  2012/03
• Role of the MYC family of Transcription factors in Medulloblastoma  [Not invited]

  KAWAUCHI Daisuke

  2011 Pediatric Neuro-Oncology Basic and Translational Research Conference  2011/05
• Enforced expression of MycN and C-Myc induces different medulloblastoma subtypes.  [Not invited]

  KAWAUCHI Daisuke

  2011 AACR annual meeting  2011/04

MISC

• ARRAY-BASED GLOBAL DNA METHYLATION PROFILING OF MOUSE BRAIN TUMORS ALLOWS COMPARISON TO HUMAN TUMORS

  Melanie Schoof; Michael Spohn; Mario Dorostkar; Sina Neyazi; Michael Bockmayr; Fredrik Swartling; Daisuke Kawauchi; Richard Gilbertson; Jessica Taylor; Yanxin Pei; Rainer Glass; Jiying Cheng; Natalia Moreno Galarza; Juergen Hench; Jochen Herms; Philipp Jurmeister; Leonille Schweizer; David Capper; Patrick Harter; Christian Thomas; Martin Hasselblatt; Mirjam Blattner-Johnson; David Jones; Stephan Frank; Kornelius Kerl; Ulrich Schueller  NEURO-ONCOLOGY  24-  158  -159  2022/06
• DYNAMIC CHROMATIN ALTERATION INDUCES ONCOGENIC HIJACKING BY ESSENTIAL TRANSCRIPTIONAL FACTORS DURING SHH MEDULLOBLASTOMA TUMORIGENESIS

  Ryo Shiraishi; Gabriele Cancila; Kohei Kumegawa; Patricia da Silva; Owen Chapman; Wang Wanchen; Maki Jami; Mikio Hoshino; Stefan Pfister; Lukas Chavez; Reo Maruyama; Olivier Ayrault; Daisuke Kawauchi  NEURO-ONCOLOGY  24-  107  -108  2022/06
• DNA METHYLATION-BASED BIOBANK OF MURINE MODELS FOR PEDIATRIC TUMORS

  Tuyu Zheng; Martin Sill; Roland Imle; Ryo Shiraishi; Wanchen Wang; Alaide Morcavallo; Louis Chesler; Daisuke Kawauchi; Olivier Ayrault; Lutsik Pavlo; Stefan M. Pfister; Lena M. Kutscher; Ana Banito; David W. Jones; Kristian W. Pajtler; Marc Zuckermann  NEURO-ONCOLOGY  24-  169  -170  2022/06
• ZFTA/C11ORF95 FUSIONS DRIVE SUPRATENTORIAL EPENDYMOMA VIA SHARED ONCOGENIC MECHANISMS

  Tuyu Zheng; David R. Ghasemi; Konstantin Okonechnikov; Andrey Korshunov; Kendra K. Maass; Martin Sill; Johannes Gojo; Ulrich Schueller; Till Milde; Stephen C. Mack; Richard J. Gilbertson; Andreas von Deimling; David T. W. Jones; Marcel Kool; Stefan M. Pfister; Felix Sahm; Daisuke Kawauchi; Kristian W. Pajtler  NEURO-ONCOLOGY  23-  13  -14  2021/06
• Analysis of epigenetic alteration required for malignant transformation of pre-neoplastic cells in a brain tumor

  Ryo Shiraishi; Mana Shimoda; Reo Maruyama; Daisuke Kawauchi  CANCER SCIENCE  112-  849  -849  2021/02
• FUNCTIONAL CHARACTERIZATION OF IKBKAP/ELP1 AS A NOVEL SHH MEDULLOBLASTOMA PREDISPOSITION GENE

  Jesus Garcia Lopez; Lena Kutscher; Marija Kojic; Brian Gudenas; Kyle Smith; Jennifer Hadley; Amar Gajjar; Giles W. Robinson; Stefan M. Pfister; Brandon J. Wainwright; Daisuke Kawauchi; Paul A. Northcott  NEURO-ONCOLOGY  22-  402  -403  2020/12
• MUTATIONS IN BRPF1 FOUND IN SHH MEDULLOBLASTOMA PREVENT INTERACTION WITH TP53 AND LEADS TO RADIORESISTANCE IN VITRO

  Mikaela Vouri; Audrey Mercier; Patricia Benites Goncalves da Silva; Konstantin Okonechnikov; Antoine Forget; Hua Yu; Anais Chivet; Marcel Kool; Stefan Pfister; Olivier Ayrault; Daisuke Kawauchi  NEURO-ONCOLOGY  22-  407  -407  2020/12
• CROSS-SPECIES GENOMICS IDENTIFIES GLI2 AS AN ONCOGENE OF C11ORF95 FUSION-POSITIVE SUPRATENTORIAL EPENDYMOMA

  Tuyu Zheng; David R. Ghasemi; Konstantin Okonechnikov; Andrey Korshunov; Martin Sill; Jens-Martin Huebner; Kendra K. Maass; Matija Snuderl; Johannes Gojo; Ulrich Schueller; Nicolas U. Gerber; Pablo Hernaiz-Driever; Till Milde; Dominik Sturm; Rebecca Chapman; Richard G. Grundy; Andreas von Deimling; David T. W. Jones; Marcel Kool; Stefan M. Pfister; Felix Sahm; Daisuke Kawauchi; Kristian W. Pajtler  NEURO-ONCOLOGY  22-  311  -311  2020/12
• YAP1 SUBGROUP SUPRATENTORIAL EPENDYMOMA REQUIRES TEAD AND NUCLEAR FACTOR I-MEDIATED TRANSCRIPTIONAL PROGRAMS FOR TUMORIGENESIS

  Kristian Pajtler; Yiju Wei; Konstantin Okonechniov; Mikaella Vouri; Felix Sahm; Jens Bunt; David Jones; Andrey Korshunov; Peter Lichter; Stefan Pfister; Marcel Kool; Wei Li; Daisuke Kawauchi  NEURO-ONCOLOGY  21-  78  -78  2019/04
• YAP1 fusion proteins mediate oncogenic activity in ependymoma via interaction with TEAD transcription factors

  Kristian W. Pajtler; Konstantin Okonechnikov; Mikaella Vouri; Sebastian Brabetz; David T. Jones; Andrey Korshunov; David Capper; Lukas Chavez; Stefan M. Pfister; Marcel Kool; Daisuke Kawauchi  CANCER RESEARCH  78-  (13)  2018/07
• Somatic CRISPR/Cas9-mediated gene editing enables versatile brain tumor modeling

  Marc Zuckermann; Britta Ismer; Volker Hovestadt; Christiane B. Knobbe-Thomsen; Marc Zapatka; Paul A. Northcott; Martine F. Roussel; Guido Reifenberger; Peter Lichter; Stefan M. Pfister; Daisuke Kawauchi; Jan Gronych; David T. Jones  CANCER RESEARCH  78-  (13)  2018/07
• YAP1 FUSION PROTEINS MEDIATE ONCOGENIC ACTIVITY IN EPENDYMOMA VIA INTERACTION WITH TEAD TRANSCRIPTION FACTORS

  Kristian W. Pajtler; Konstantin Okonechnikov; Mikaella Vouri; Sebastian Brabetz; David T. W. Jones; Audrey Korshunov; David Capper; Lukas Chavez; Stefan M. Pfister; Marcel Kool; Daisuke Kawauchi  NEURO-ONCOLOGY  20-  78  -78  2018/06
• WHAT THE FOX SAY? A MOLECULAR ANALYSIS OF FOXR2 IN PEDIATRIC BRAIN TUMORS

  Sjoerd van Rijn; Mikaella Vouri; Stefan M. Pfister; Daisuke Kawauchi; Marcel Kool  NEURO-ONCOLOGY  20-  69  -69  2018/06
• YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE

  Kristian W. Pajtler; Sebastian Brabetz; David Capper; Mikaella Vouri; Monika Mauermann; Norman Mack; Laura Sieber; Hendrik Witt; David T. W. Jones; Andrey Korshunov; Stefan M. Pfister; Marcel Kool; Daisuke Kawauchi  NEURO-ONCOLOGY  19-  17  -18  2017/06
• DYSFUNCTION OF THE CHROMATIN REMODELER Chd7 CAUSES ABNORMAL CEREBELLAR DEVELOPMENT AND ACCELERATES MEDULLOBLASTOMA FORMATION

  Daisuke Kawauchi; Weijun Feng; Huiqin Koerkel-Qu; Huan Deng; Elisabeth Serger; Laura Sieber; Jenna Lieberman; Malin Jansen; Anna Neuerburg; Olga Friesen; Marc Zuckermann; Vijayanand Rajendran; Bola Hanna; Jan Gronych; Olivier Ayrault; Andrey Korshunov; David Jones; Marcel Kool; Paul Northcott; Felipe Cortes-Ledesma; Stefan Pfister; Haikun Liu  NEURO-ONCOLOGY  18-  100  -100  2016/06
• FOUR NEW BRAIN TUMOR ENTITIES EMERGE FROM MOLECULAR CLASSIFICATION OF CNS PNETs

  Dominik Sturm; Brent Orr; Umut Toprak; Volker Hovestadt; David Jones; David Capper; Sjoerd van Rijn; Daisuke Kawauchi; Peter Lichter; Andrey Korshunov; Stefan Pfister; David Ellison; Marcel Kool  NEURO-ONCOLOGY  18-  11  -11  2016/06
• YAP1-MAMLD1 FUSIONS ALONE ARE SUFFICIENT TO FORM SUPRATENTORIAL EPENDYMOMA-LIKE TUMORS IN MICE

  Kristian W. Pajtler; Sebastian Brabetz; Monika Mauermann; Norman Mack; Laura Sieber; David T. W. Jones; Hendrik Witt; Huiqin Koerkel-Qu; Marc Zuckermann; Jan Gronych; Andrey Korshunov; David Capper; Hai-Kun Liu; Stefan M. Pfister; Marcel Kool; Daisuke Kawauchi  NEURO-ONCOLOGY  18-  37  -37  2016/06
• SOMATIC CRISPR/Cas9-MEDIATED TUMOR SUPPRESSOR DISRUPTION ENABLES VERSATILE BRAIN TUMOR MODELING

  Marc Zuckermann; Volker Hovestadt; Christiane B. Knobbe-Thomsen; Marc Zapatka; Paul A. Northcott; Kathrin Schramm; Jelena Belic; David T. W. Jones; Barbara Tschida; Branden Moriarity; David Largaespada; Martine F. Roussel; Andrey Korshunov; Guido Reifenberger; Stefan M. Pfister; Peter Lichter; Daisuke Kawauchi; Jan Gronych  NEURO-ONCOLOGY  18-  142  -142  2016/06
• Somatic CRISPR/Cas9-mediated tumor suppressor disruption enables versatile brain tumor modeling

  Marc Zuckermann; Volker Hovestadt; Christiane B. Knobbe-Thomsen; Marc Zapatka; Paul A. Northcott; Kathrin Schramm; Jelena Belic; David T. W. Jones; Barbara Tschida; Branden Moriarity; David Largaespada; Martine F. Roussel; Andrey Korshunov; Guido Reifenberger; Stefan M. Pfister; Peter Lichter; Daisuke Kawauchi; Jan Gronych  CANCER RESEARCH  75-  2015/12
• Pediatric medulloblastoma: Drug screens and preclinical studies

  Marie Morfouace; Yogesh Patel; Anang Shelat; Daisuke Kawauchi; Giles W. Robinson; Kip Guy; Richard J. Gilbertson; Clinton Stewart; Amar Gajjar; Martine F. Roussel  CANCER RESEARCH  75-  2015/12
• Myc and Miz1 in medulloblastoma

  BaoHan T. Vo; Elmar Wolf; Daisuke Kawauchi; Jerold Rehg; David Finkelstein; Brian Murphy; Martin Eilers; Martine F. Roussel  CANCER RESEARCH  74-  (19)  2014/10
• SMARCA4 AND THE CHROMATIN REMODELING COMPLEX SWI/SNF IN BRAIN DEVELOPMENT AND DISEASE

  Christin Schmidt; Kornelius Kerl; Jan Gronych; Daisuke Kawauchi; Peter Lichter; Ulrich Schueller; Stefan Pfister; Marcel Kool  NEURO-ONCOLOGY  16-  85  -85  2014/06
• ROLE OF THE LIM DOMAIN BINDING PROTEIN LDB1 AND THE LIM ONLY FACTOR LMO4 IN SHH SUBGROUP MEDULLOBLASTOMA

  Sonja Hutter; Paul A. Northcott; Marcel Kool; Stefan Pfister; Daisuke Kawauchi; David T. Jones  NEURO-ONCOLOGY  16-  84  -84  2014/06
• CROSS-SPECIES EPIGENETICS IDENTIFIES A CRITICAL ROLE FOR VAV1 IN THE MAINTENANCE OF SONIC HEDGEHOG SUBGROUP MEDULLOBLASTOMAS

  Janet Lindsey; Daisuke Kawauchi; Ed Schwalbe; David Solecki; Peter McKinnon; Jim Olson; James Hayden; Richard Grundy; David Ellison; Dan Williamson; Simon Bailey; Martine Roussel; Steven Clifford  NEURO-ONCOLOGY  16-  79  -79  2014/06
• IN VIVO ELECTROPORATION-BASED SPONTANEOUS MOUSE MODEL OF MYC-DRIVEN MEDULLOBLASTOMA

  Daisuke Kawauchi; Jerold Rehg; David Finkelstein; Frederique Zindy; Timothy Phoenix; Richard Gilbertson; Stefan Pfister; Martine Roussel  NEURO-ONCOLOGY  16-  76  -76  2014/06
• A mouse model of the most aggressive subgroup of human medulloblastoma

  Daisuke Kawauchi; Giles Robinson; Tamar Uziel; Paul Gibson; Jerold Rehg; Cuilan Gao; David Finkelstein; Chunxu Qu; Stanley Pounds; David W. Ellison; Richard J. Gilbertson; Martine F. Roussel  CANCER RESEARCH  72-  2012/04
• Cell of origin in pediatric medulloblastomas

  Daisuke Kawauchi; Giles Robinson; Tamar Uziel; David W. Elisson; Richard J. Gilbertson; Martine F. Roussel  CANCER RESEARCH  72-  2012/04
• ROLE OF THE MYC FAMILY OF TRANSCRIPTION FACTORS IN MEDULLOBLASTOMA

  Daisuke Kawauchi; Giles Robinson; Tamar Uziel; Jerold Rehg; Cuilian Gao; David Finkelstein; Liqin Zhu; Chunxu Qu; Stanley Pounds; David Ellison; Richard Gilbertson; Martine Roussel  NEURO-ONCOLOGY  13-  I13  -I13  2011/05
• Epigenomics identifies conserved DNA methylation events associated with medulloblastoma development in humans and mice

  Janet C. Lindsey; Ed C. Schwalbe; Daisuke Kawauchi; Jim M. Olson; Peter J. McKinnon; Richard J. Gilbertson; Martine F. Roussel; David W. Ellison; Simon Bailey; Steven C. Clifford  CANCER RESEARCH  71-  2011/04
• Enforced expression of MycN and C-Myc induces different medulloblastoma subtypes

  Daisuke Kawauchi; Giles Robinson; Tamar Uziel; Jerold Rehg; Frederique Zindy; Chunxu Qu; Amar Gajjar; Richard J. Gilbertson; Martine F. Roussei  CANCER RESEARCH  71-  2011/04
• Cross-inhibitory regulation of transcriptional factor genes specifying neuronal identity in the developing cerebellum

  Daisuke Kawauchi; Tetsuichiro Saito  NEUROSCIENCE RESEARCH  61-  S92  -S92  2008
• Mbh1 is involved in cerebellar granule cell differentiation downstream of a proneural gene, Math 1

  Daisuke Kawauchi; Tetsuichiro Saito  NEUROSCIENCE RESEARCH  58-  S85  -S85  2007
• The role of calmodulin 1 in the migration of precerebellar neurons

  Hiroaki Kobayashi; Shunsuke Saragai; Atsushi Naito; Daisuke Kawauchi  NEUROSCIENCE RESEARCH  58-  S203  -S203  2007
• Classic cadherins regulate tangential migration of precerebellar neurons in the caudal hindbrain (vol 133, pg 1923, 2006)

  H Taniguchi; D Kawauchi; K Nishida; F Murakami  DEVELOPMENT  133-  (10)  2087  -2087  2006/05
• Separation of Fe and Sn-Cu phases in an Fe-Sn-Cu-B system

  Hideki Ono-Nakazato; Kenji Taguchi; Daisuke Kawauchi; Tateo Usui  MATERIALS TRANSACTIONS  47-  (3)  864  -867  2006/03
• Mbh1 is a potential downstream target of Math1 in differentiating cerebellar granule cells

  Daisuke Kawauchi; Tetsuichiro Saito  NEUROSCIENCE RESEARCH  55-  S142  -S142  2006

Industrial Property Rights

• 特願2024- 70495:神経膠腫治療剤、および神経膠腫細胞の増殖抑制方法  2024  /04/24

  上阪直史, 川内大輔, 金村米博  国立大学法人 東京医科歯科大学 【, 国立研究開発法人国立精神・神経医療研究センター, 独立行政法人国立病院機構
• 特願2023-186968:抗腫瘍剤、抗腫瘍剤のスクリーニング方法、および予後検査薬  2023年/10/31

  稲垣直之, 馬場健太郎, 福士亜美, 金村米博, 勝間亜沙子, 芳賀永, 石原誠一郎, 川内大輔, 青木吉嗣  国立大学法人奈良先端科学技術大学院大学, 独立行政法人国立病院機構, 国立大学法人北海道大学, 国立研究開発法人国立精神・神経医療研究センター

Awards & Honors

• 2023/06 Fudan University Fudan University Visiting Scholar
  
• 2020 Brain Tumour Charity Collaborative Team Award (GN-000690)
   Targeting Src as a Driver of CNS Grp 4 Medulloblastoma and Glioma 

  受賞者: Louis Chesler;Olivier Ayrault;Daisuke Kawauchi
• 2017 Brain Tumour Charity Collaborative Team Award (GN-000356)
   Identification, in-vivo modelling and therapeutic targeting of superenhancer-driven oncogenes in Group 3 medulloblastoma 

  受賞者: Louis Chesler;Stefan M. Pfister;Willam A. Weiss;Daisuke Kawauchi
• 2011 St Jude intramural grant: The Anderson fellowship
   

  受賞者: 川内 大輔
• 2009 公益財団法人 持田記念医学薬学振興財団 留学補助金
   

  受賞者: 川内 大輔
• 2006 成茂神経科学研究助成基金
   

  受賞者: 川内 大輔

Research Grants & Projects

• N/A

  日本医療研究開発機構(AMED)：次世代がん医療加速化研究事業(P-PROMOTE)

  Date (from‐to) : 2023/09 -2026/03 

  Author : Naofumi Uesaka; Daisuke Kawauchi; Reo Maruyama
• N/A

  日本医療研究開発機構(AMED)：次世代がん医療加速化研究事業(P-PROMOTE)

  Date (from‐to) : 2023/09 -2026/03 

  Author : Daisuke Kawauchi; Reo Maruyama; Yonehiro Kanemura
• Understanding of functional interaction between tumor cells and brain microenvironment in brain tumor development

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

  Date (from‐to) : 2022/04 -2025/03 

  Author : 川内 大輔; 丸山 玲緒; 上阪 直史; 岩崎 真樹
• 手術検体を用いた脳腫瘍細胞と正常神経細胞間のてんかん原性回路の解明

  日本学術振興会：科学研究費助成事業 基盤研究(C)

  Date (from‐to) : 2022/04 -2025/03 

  Author : 飯島 圭哉; 岩崎 真樹; 川内 大輔; 三輪 秀樹
• The study of novel therapeutic avenues for pediatric brain tumors based on molecular mechanisms of their tumorigenesis

  AMED：革新的がん医療実用化研究事業

  Date (from‐to) : 2020/04 -2022/03 

  Author : 川内大輔; 市村幸一; 金村米博; 岩﨑真樹; 永樂元次; 星野幹雄; 木嶋教行
• 細胞―基質間の力を基盤とした細胞移動と神経回路形成機構の解明およびその破綻による病態の解析

  日本医療研究開発機構(AMED)：AMED-CREST

  Date (from‐to) : 2017 -2022 

  Author : 稲垣直之; 金村米博; 川内大輔
• 神経発生工学とヒト腫瘍ゲノム学を駆使した脳腫瘍発症の新規メカニズム解明

  日本学術振興会：科学研究費助成事業 国際共同研究加速基金(帰国発展研究)

  Date (from‐to) : 2020 -2021 

  Author : 川内 大輔

   

  小脳に発生する悪性脳腫瘍である髄芽腫の研究では、SHH型髄芽腫で高頻度に機能欠損変異を持つBCORがインシュリン様成長因子2の発現を誘導することにより腫瘍増殖に関わることを証明した(Kutscher et al. Genes Dev. 2020)。またGroup4型髄芽腫では我々がこれまでに同定した癌シグナルであるSRCを小脳の様々な細胞において特異的に活性化させることにより発がん能を検証し、Group4型髄芽腫の起源細胞を同定した(Adachi et al.投稿準備中)。さらに大脳に発生するテント上上衣腫の研究では、国際共同研究により新たにヒトで同定された融合遺伝子の発がん性をマウス生体内で証明し、その下流シグナルの同定に成功した(Kupp et al., Cancer Discov. in press ; Arabzade et al. Cancer Discov. in press ; Zheng et al. Cancer Discov. in press)。
• Mechanisms to form neural circuits of the spinal cord and cerebellum

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (A)

  Date (from‐to) : 2008 -2011 

  Author : SAITO Tetsuichiro; MUROYAMA Yuko; KAWAUCHI Daisuke

   

  The spinal cord and cerebellum are morphologically and functionally different. Our previous results, however, have suggested that commissural neurons in the spinal cord and granule cells in the cerebellum are generated by the same genes. This research project has revealed novel relationship between the genes in neuronal differentiation and neural circuit formation in the spinal cord and cerebellum.
• 小脳興奮性ニューロン群の個性決定機構の解析

  日本学術振興会：科学研究費助成事業 若手研究(B)

  Date (from‐to) : 2008 -2009 

  Author : 川内 大輔

   

  無脊椎動物から高等脊椎動物まで広く保存されているプロニューラル因子は神経分化開始のスイッチとして機能する。しかし、これら因子が制御する遺伝子に関する知見は未だ乏しい。本研究では、小脳興奮性ニューロンである小脳核ニューロンと小脳顆粒細胞が共通のプロニューラル因子Math1の下流で異なる個性をどのように獲得するか、その解明を目指す。今年度は、交付申請書の研究実施計画に沿って、小脳興奮性ニューロン群の解剖学的知見を得るとともに、プロニューラル因子Math1と小脳興奮性ニューロンに特異的に発現するホメオボックス遺伝子Mbh2の間の遺伝学的な関係を明らかにした。 1) 小脳興奮性ニューロンの標識と発達の解析 電気穿孔法を用いてレポーター遺伝子EYFPを小脳神経前駆細胞に導入して、小脳核ニューロンおよび小脳顆粒細胞を標識することにより、遺伝子導入時期に依存して標識ニューロンの種類や移動距離・経路が異なることがわかった。 2) Mbh2の発現制御機構の解析 Math1 siRNAs を生体内電気穿孔法で小脳興奮性ニューロンに導入した結果、Math1の発現低下に伴いMbh2の発現が消失した。逆にMath1の強制発現はMbh2の発現を誘導する。また免疫クロマチン沈降法を用いて、Math1がMbh2ゲノム領域に結合することを示した。以上の結果から小脳においてMbh2がMath1の標的遺伝子であることが明らかとなった(Kawauchi and Saito, 2008)。現在Mbh2遺伝子にLacZを付与したレポーター遺伝子を用い、小脳核ニューロンあるいは小脳顆粒細胞特異的なMbh2エンハンサーを解析中である。 3) Math1依存的分化カスケードの更なる同定 申請者は別の研究でMbh1、Mbh2の下流候補遺伝子を脊髄において同定しており(投稿準備中)、その結果を踏まえ、現在小脳において解析中である。
• 小脳顆粒細胞の分化の初期過程における分子機構の解析

  日本学術振興会：科学研究費助成事業 若手研究(B)

  Date (from‐to) : 2006 -2007 

  Author : 川内 大輔

   

  小脳は運動制御を司る重要な器官である。小脳皮質を構成する主要な神経細胞である小脳顆粒細胞は、苔状線維からの入力を統合し、平行線維を通じて信号を出力することにより、小脳が機能的に働くことに大いに寄与している。本研究では、顆粒細胞分化の初期過程における分子機構を解明すべく、顆粒細胞の分化開始に必須の転写因子であるMath1に着目し、その下流で働く遺伝子群の同定とその機能解明に取り組む。今年度は、交付申請書の研究実施計画に沿って、前年度から着目しているMath1下流候補遺伝子Mbh1の機能解析を推進すると共に、更なる下流遺伝子の同定を目指した。 1.マウス生体内遺伝子導入法によるルMbh1の機能解析 顆粒細胞の分化の初期過程においてMbh1の機能を探るため、申請者の研究室で既に報告しているMbh1のドミネガ体をコードする遺伝子を、生体内遺伝子導入法を用いてマウス胎児の小脳へ導入した。ドミネガ体が導入された小脳では、外顆粒層の形成が阻害されるなど顆粒細胞の分化に異常が見られた。この結果はMbh1が顆粒細胞の分化に関与している可能性を示唆している。 2-a.Math1強制発現系を用いた、Math1下流遺伝子群の同定 Math1を小脳に異所的に発現させることにより誘導される遺伝子群を探索した。その結果、前年度から着目しているMbh1に加え、同じファミリーに属するMbh2など小脳で発現する幾つかの遺伝子の誘導が観察された。 2-b.Mbh2の発現制御機構の解析 小脳顆粒細胞へのMath1 siRNAsの導入により、Mathlの発現低下に伴い、Mbh2の発現が低下することを示した。またクロマチン免疫沈降法により、Math1がMbh2のゲノムの3'領域に結合していることを示し、Mbh1と同様にMbh2もMath1の標的遺伝子であることを明らかにした。

Teaching Experience

Theory of Research Methods in NeuroscienceTheory of Research Methods in Neuroscience Shinshu University

Committee Membership

• 2015/01 -2015/06   Curie institut, France   PhD thesis committee

Media Coverage

• 小児悪性脳腫瘍「テント上上衣腫」関連の新たながんシグナルを発見

  Date : 2021/05/21

  Writer: Other than myself

  Publisher, broadcasting station: QLife, Inc.

  Program, newspaper magazine: がんプラス

  https://cancer.qlife.jp/news/article15292.html Internet
• 国立精神・神経医療研究センター、小児悪性脳腫瘍の進行に関わる新たながんシグナルを発見〜がん細胞を増殖させる遺伝子変異の研究が導く新しい治療戦略づくり〜

  Date : 2021/04/27

  Writer: Other than myself

  Publisher, broadcasting station: 日経バイオテク

  Internet
• 小児悪性脳腫瘍の進行に関わる新たながんシグナルを発見―がん細胞を増殖させる遺伝子変異の研究が導く新しい治療戦略づくり―

  Date : 2021/04/20

  Writer: Myself

  Publisher, broadcasting station: AMED HP (https://www.amed.go.jp/news/release_20210422.html)

  Internet
• 小児脳腫瘍の進行に関わる新たな遺伝子変異を発見―がん細胞の個性に応じた治療戦略の基盤づくり―

  Date : 2020/08/20

  Writer: Myself

  Publisher, broadcasting station: AMED HP (https://www.amed.go.jp/news/release_20200820-01.html)

  Internet
• A mouse model of the most aggressive subgroup of human medulloblastoma.

  Date : 2012

  Writer: Myself

  Publisher, broadcasting station: ライフサイエンス新着論文レビュー

  https://first.lifesciencedb.jp/archives/4477 Internet
• 「競争よりも協調、海外医学研究における共同研究への高い意識」

  Writer: Myself

  Publisher, broadcasting station: 日本フンボルト協会HP

  Program, newspaper magazine: 在独PIによるドイツの学術研究の紹介（第６回）

  Internet

Others

• 脳科学辞典「小脳原器」

  川内大輔
• 脳科学辞典「髄芽腫」

  木嶋教行, 川内大輔

Other link

researchmap

https://researchmap.jp/d_kawauchi