Journal of community hospital internal medicine perspectives 12 (5) 124 - 125 2022
Intracranial Hemorrhage Caused by Acute-Onset Severe Hypernatremia.Takahiro Goshima; Teruhiko Terasawa; Mitsunaga Iwata; Asako Matsushima; Tomonori Hattori; Hiroshi SasanoJournal of community hospital...See More
Molecular and clinical oncology 7 (4) 673 - 676 2017/10
Monitoring of recurrent and superior laryngeal nerve function using an Airwayscope™ during thyroid surgery.Kei Ijichi; Hiroshi Sasano; Megumi Harima; Shingo MurakamiMolecular and clinical oncology 7 (...See More
Tidal volume and airway pressure under percutaneous transtracheal ventilation without a jet ventilator: comparison of high-flow oxygen ventilation and manual ventilation in complete and incomplete upp...See More
Oto-Rhino-Laryngology Tokyo 56 (5) 326 - 329 0386-9687 2014
Recurrent laryngeal nerve and superior laryngeal nerve external brunch monitoring with Airwayscope® and facial nerve stimulator in thyroid surgeryKei Ijichi; Daisuke Kawakita; Shingo Murakami; Megumi ...See More
Recurrent laryngeal nerve and superior laryngeal nerve external brunch monitoring with Airwayscope® and facial nerve stimulator in thyroid surgery
Markedly elevated procalcitonin in early postoperative period in pediatric open heart surgery: a prospective cohort study.Etsuko Minami; Shoji Ito; Takeshi Sugiura; Yoshihito Fujita; Hiroshi Sasano; K...See More
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 日本臨床麻酔学会 33 (5) 808 - 814 0285-4945 2013/09
Historical Research on the Standardized Color Code of Syringe Labels to Reduce Errors in the Administration of Drugs in AnesthesiaSHIDA Kyoko; SOBUE Kazuya; HIRATE Hiroyuki; ARIMA Hajime; FUJITA Yoshi...See More
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 日本臨床麻酔学会 33 (5) 826 - 829 0285-4945 2013/09
Epidural Hematoma after Epidural Block in a Case with Severe Vertebral DeformationMINOWA Takahisa; HIRATE Hiroyuki; SUGIURA Takeshi; SASANO Hiroshi; SOBUE Kazuya; AZAMI TakafumiTHE JOURNAL OF JAPAN SO...See More
Spinal cord stimulation for a woman with complex regional pain syndrome who wished to get pregnant.Shoji Ito; Takeshi Sugiura; Takafumi Azami; Hiroshi Sasano; Kazuya SobueJournal of anesthesia 27 (1) ...See More
Masui. The Japanese journal of anesthesiology 60 (9) 1101 - 3 0021-4892 2011/09
[Interscalene block combined with general anesthesia under spontaneous breathing in a patient with a giant bulla].Takeshi Sugiura; Rumiko Akiyoshi; Rina Kato; Hiroshi Sasano; Kazuya SobueMasui. The Ja...See More
Nutrition (Burbank, Los Angeles County, Calif.) 27 (5) 557 - 60 2011/05
Optimal prediction of the central venous catheter insertion depth on a routine chest x-ray.Yumiko Uchida; Masaki Sakamoto; Hiroki Takahashi; Yoichi Matsuo; Hitoshi Funahashi; Hiroshi Sasano; Kazuya So...See More
Journal of the Japanese Society of Intensive Care Medicine The Japanese Society of Intensive Care Medicine 17 (4) 499 - 503 1340-7988 2010/10
A young woman with anti-N-methyl-D-aspartate receptor encephalitis with ovarian teratoma who required long-term intensive care for seizure control with difficulty : a case reportINOUE Asuka; ITO Shoji...See More
A novel skin-traction method is effective for real-time ultrasound-guided internal jugular vein catheterization in infants and neonates weighing less than 5 kilograms.Masato Morita; Hiroshi Sasano; Ta...See More
Jomyaku Keicho Eiyo Japanese Society for Parenteral and Enteral Nutrition 24 (3) 769 - 774 1344-4980 2009/05
Managing sodium concentration in relation to water balance and correcting dysnatremiasHIRATE Hiroyuki; SASANO Hiroshi; FUJITA Yoshito; ITO Syoji; AZAMI Takafumi; SUGIURA Takeshi; SOBUE KazuyaJomyaku K...See More
Continuous positive airway pressure applied through a bronchial blocker as a treatment for hypoxemia due to stenosis of the left main bronchus.Hiroshi Sasano; Nobuko Sasano; Shoji Ito; Yoshihito Fujit...See More
Acta histochemica et cytochemica 42 (1) 9 - 14 2009/02
Localization of reversion-induced LIM protein (RIL) in the rat central nervous system.Yuko Iida; Toshiyuki Matsuzaki; Tetsuro Morishima; Hiroshi Sasano; Kiyofumi Asai; Kazuya Sobue; Kuniaki TakataActa...See More
Skin-traction method prevents the collapse of the internal jugular vein caused by an ultrasound probe in real-time ultrasound-assisted guidance.Hiroshi Sasano; Masato Morita; Takafumi Azami; Shoji Ito...See More
A simple, lightweight CPAP-delivery device, composed of a three-way stopcock, for the nondependent lung.Hiroshi Sasano; Nobuko Sasano; Shoji Ito; Takafumi Azami; Masato Morita; Akinori Takeuchi; Kazuy...See More
Time progression from the patient's operating room entrance to incision: factors affecting anesthetic setup and surgical preparation times.Nobuko Sasano; Masato Morita; Takeshi Sugiura; Hiroshi Sasano...See More
Orotracheal intubation with an AirWay Scope in a patient with Treacher Collins syndrome.Hironobu Iguchi; Nobuko Sasano; Minhye So; Hiroyuki Hirate; Hiroshi Sasano; Hirotada KatsuyaJournal of anesthesi...See More
ITO Hiroaki; SOBUE Kazuya; HIRATE Hiroyuki; AZAMI Takafumi; ITO Shoji; SASANO Hiroshi; TAKEUCHI Akinori; KATSUYA Hirotada
Journal of the Japanese Society of Intensive Care Medicine The Japanese Society of Intensive Care Medicine 14 (3) 345 - 346 1340-7988 2007/07
Successful use of nifekalant hydrochloride for 37 days in a patient with refractory ventricular tachycardia following septic shockITO Hiroaki; SOBUE Kazuya; HIRATE Hiroyuki; AZAMI Takafumi; ITO Shoji;...See More
Journal of anesthesia 21 (1) 72 - 5 0913-8668 2007
Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) during laparotomy.Nobuko Sasano; Yoshihito Fujita; Minhye So; Kazuya S...See More
Susumu Ishida; Akinori Takeuchi; Takafumi Azami; Kazuya Sobue; Hiroshi Sasano; Hirotada Katsuya; Joseph A Fisher
Journal of anesthesia 21 (2) 181 - 6 0913-8668 2007
Cardiac output increases the rate of carbon monoxide elimination in hyperpneic but not normally ventilated dogs.Susumu Ishida; Akinori Takeuchi; Takafumi Azami; Kazuya Sobue; Hiroshi Sasano; Hirotada ...See More
Journal of anesthesia 21 (4) 467 - 71 0913-8668 2007
The skin-traction method increases the cross-sectional area of the internal jugular vein by increasing its anteroposterior diameter.Masato Morita; Hiroshi Sasano; Takafumi Azami; Nobuko Sasano; Hirota...See More
Vagal nerve activity contributes to improve the efficiency of pulmonary gas exchange in hypoxic humans.Shoji Ito; Hiroshi Sasano; Nobuko Sasano; Junichiro Hayano; Joseph A Fisher; Hirotada KatsuyaExpe...See More
Use of ketamine to facilitate opioid withdrawal in a child.Hiroaki Ito; Kazuya Sobue; Hiroyuki Hirate; Takeshi Sugiura; Minhye So; Takafumi Azami; Hiroshi Sasano; Hirotada KatsuyaAnesthesiology 104 (5...See More
Marat Slessarev; Ron Somogyi; David Preiss; Alex Vesely; Hiroshi Sasano; Joseph A Fisher
Critical care medicine 34 (3) 829 - 34 0090-3493 2006/03
Efficiency of oxygen administration: sequential gas delivery versus "flow into a cone" methods.Marat Slessarev; Ron Somogyi; David Preiss; Alex Vesely; Hiroshi Sasano; Joseph A FisherCritical care med...See More
Journal of anesthesia 20 (2) 106 - 8 0913-8668 2006
Postextubation airway management with nasal continuous positive airway pressure in a child with Down syndrome.Hiroaki Ito; Kazuya Sobue; Min-Hye So; Takeshi Sugiura; Hiroshi Sasano; Akinori Takeuchi; ...See More
Journal of anesthesia 20 (3) 253 - 4 0913-8668 2006
Use of landiolol in the perioperative management of supraventricular tachycardia.Hiroaki Ito; Kazuya Sobue; Minhye So; Hiroyuki Hirate; Takeshi Sugiura; Takafumi Azami; Hiroshi Sasano; Hirotada Katsuy...See More
RB Somogyi; AE Vesely; D Preiss; E Prisman; G Volgyesi; T Azami; S Iscoe; JA Fisher; H Sasano
ANAESTHESIA AND INTENSIVE CARE AUSTRALIAN SOC ANAESTHETISTS 33 (6) 726 - 732 0310-057X 2005/12
Precise control of end-tidal carbon dioxide levels using sequential rebreathing circuitsRB Somogyi; AE Vesely; D Preiss; E Prisman; G Volgyesi; T Azami; S Iscoe; JA Fisher; H SasanoANAESTHESIA AND INT...See More
Journal of clinical monitoring and computing 19 (3) 215 - 7 1387-1307 2005/06
The changes in pulmonary capillary blood flow and anatomical dead space during pulmonary resection under one-lung ventilation.Shoji Ito; Hiroshi Sasano; Kazuya Sobue; Takafumi Azami; Takako Tsuda; Hir...See More
Journal of anesthesia 19 (4) 309 - 10 0913-8668 2005
Anesthetic and airway management of general anesthesia in a patient with Meckel-Gruber syndrome.Mitsunori Miyazu; Kazuya Sobue; Hiroaki Ito; Takafumi Azami; Shoji Ito; Akinori Takeuchi; Hiroshi Sasano...See More
Canadian journal of anaesthesia = Journal canadien d'anesthesie 51 (9) 875 - 9 0832-610X 2004/11
Cerebral fat embolism diagnosed by magnetic resonance imaging at one, eight, and 50 days after hip arthroplasty: a case report.Nobuko Sasano; Susumu Ishida; Shinichiro Tetsu; Hiroe Takasu; Kiyoshi Ish...See More
Alex E Vesely; Ron B Somogyi; Hiroshi Sasano; Nobuko Sasano; Joseph A Fisher; James Duffin
Environmental research 94 (3) 227 - 33 0013-9351 2004/03
The effects of carbon monoxide on respiratory chemoreflexes in humans.Alex E Vesely; Ron B Somogyi; Hiroshi Sasano; Nobuko Sasano; Joseph A Fisher; James DuffinEnvironmental research 94 (3) 227 - 33 0...See More
Journal of anesthesia 18 (4) 310 - 2 0913-8668 2004
A case of complex regional pain syndrome type II after transradial coronary intervention.Nobuko Sasano; Takako Tsuda; Hiroshi Sasano; Shoji Ito; Kazuya Sobue; Hirotada KatsuyaJournal of anesthesia 18 ...See More
A simple breathing circuit to maintain isocapnia during measurements of the hypoxic ventilatory response.Andreas Fahlman; Sue Jackson; John Terblanche; Joseph A Fisher; Alex Vesely; Hiroshi Sasano; Ka...See More
Nobuko Sasano; Alex E Vesely; Junichiro Hayano; Hiroshi Sasano; Ron Somogyi; David Preiss; Kiyoyuki Miyasaka; Hirotada Katsuya; Steve Iscoe; Joseph A Fisher
American journal of physiology. Heart and circulatory physiology 282 (3) H973-6 0363-6135 2002/03
Direct effect of Pa(CO2) on respiratory sinus arrhythmia in conscious humans.Nobuko Sasano; Alex E Vesely; Junichiro Hayano; Hiroshi Sasano; Ron Somogyi; David Preiss; Kiyoyuki Miyasaka; Hirotada Kats...See More
Nobuko Sasano; Alex E Vesely; Junichiro Hayano; Hiroshi Sasano; Ron Somogyi; David Preiss; Kiyoyuki Miyasaka; Hirotada Katsuya; Steve Iscoe; Joseph A Fisher
American journal of physiology. Heart and circulatory physiology 282 (3) H973-6 0363-6135 2002/03
JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM ELSEVIER SCIENCE BV 77 (1) 60 - 67 0165-1838 1999/07
Effects of sympathetic nerve blockades on low-frequency oscillations of human earlobe skin blood flowH Sasano; J Hayano; T Tsuda; H KatsuyaJOURNAL OF THE AUTONOMIC NERVOUS SYSTEM ELSEVIER SCIENCE BV 7...See More
Nihon Kyukyu Igakukai Zasshi Japanese Association for Acute Medicine 8 (8) 325 - 330 0915-924X 1997
What is expected of "The consultant physician at the 911 dispatch table"? Necessity of the physician for the present ambulance system.:Necessity of the Physician for the Present Ambulance SystemMabuch...See More
H. Sasano; N. Sasano; S. Ishida; N. Oda; M. Miura; E. Baba; M. Yamada; T. Moriya; T. Takamiya; J. Hayano; A. Takeuchi; H. Katsuya
Japanese Journal of Anesthesiology 43 (10) 1454 - 1460 0021-4892 1994 [Refereed]
Periodical blood pressure variation during cardiopulmonary bypass - Effects of cervicothoracic epidural anesthesia and phentolamineH. Sasano; N. Sasano; S. Ishida; N. Oda; M. Miura; E. Baba; M. Yamada...See More
SUGIURA Takeshi; SO MinHye; KOMURA Hidefumi; HIRATE Hiroyuki; FUJITA Yoshihito; AZAMI Takahumi; ITO Shoji; SASANO Hiroshi; SOBUE Kazuya Journal of Japan Society of Pain Clinicians 18- (4) 384 -387 2011/09
Pramipexole relieves pain in a patient with painful leg movement disorderSUGIURA Takeshi; SO MinHye; KOMURA Hidefumi; HIRATE Hiroyuki; FUJITA Yoshihito; AZAMI Takahumi; ITO Shoji; SASANO Hiroshi; SOBU...See More
SUGIURA Takeshi; SO MinHye; KOMURA Hidefumi; HIRATE Hiroyuki; FUJITA Yoshihito; AZAMI Takahumi; ITO Shoji; SASANO Hiroshi; SOBUE Kazuya Journal of Japan Society of Pain Clinicians 18- (4) 384 -387 2011/09
SHIDA Kyoko; HIRATE Hiroyuki; AZAMI Takafumi; SASANO Hiroshi; SOBUE Kazuya 日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia 31- (4) 707 -713 2011/07
"NCU Anesthetic Panic Card" and Its UsefulnessSHIDA Kyoko; HIRATE Hiroyuki; AZAMI Takafumi; SASANO Hiroshi; SOBUE Kazuya 日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia 31- (4) 70...See More
SHIDA Kyoko; HIRATE Hiroyuki; AZAMI Takafumi; SASANO Hiroshi; SOBUE Kazuya 日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia 31- (4) 707 -713 2011/07
SAWADA Maiko; USHIJIMA Kazuo; KANO Tatsuhiko; SASANO Hiroshi; KATSUYA Hirotada 日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine 18- (3) 393 -396 2011/07
An effective tracheostomy in a child with a respiratory tract disorder and severe scoliosis in association with congenital muscular dystrophySAWADA Maiko; USHIJIMA Kazuo; KANO Tatsuhiko; SASANO Hirosh...See More
SAWADA Maiko; USHIJIMA Kazuo; KANO Tatsuhiko; SASANO Hiroshi; KATSUYA Hirotada 日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine 18- (3) 393 -396 2011/07
SASANO Hiroshi; MIZUOCHI Yuuichiro; ITO Syouji; AZAMI Takafumi; FUJITA Yoshihito; SOBUE Kazuya 日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia 31- (3) 375 -384 2011/05
Induction of Ultrasound Guidance for Catheterization of the Epidural SpaceSASANO Hiroshi; MIZUOCHI Yuuichiro; ITO Syouji; AZAMI Takafumi; FUJITA Yoshihito; SOBUE Kazuya 日本臨床麻酔学会誌 = The Journal of Jap...See More
SASANO Hiroshi; MIZUOCHI Yuuichiro; ITO Syouji; AZAMI Takafumi; FUJITA Yoshihito; SOBUE Kazuya 日本臨床麻酔学会誌 = The Journal of Japan Society for Clinical Anesthesia 31- (3) 375 -384 2011/05
Changes in dead space can explain part of the reduction in gas exchange efficiency found, not necessarily linked to respiratory sinus arrhythmia - ReplyHiroshi Sasano; Shoji Ito; Nobuko Sasano EXPERI...See More
SASANO HIROSHI; AZAMI TAKAUMI; SASANO NOBUKO; ISHIDA SUSUMU; TAKEUCHI AKINORI; ITO SHOJI; SOUBE KAZUYA Nagoya medical journal 49- (1) 71 -75 2007/10
Development of Sequential Gas Delivery System and Oxygen Masks for Respiratory Droplet Infection ControlSASANO HIROSHI; AZAMI TAKAUMI; SASANO NOBUKO; ISHIDA SUSUMU; TAKEUCHI AKINORI; ITO SHOJI; SOUBE ...See More
ITO SHOJI; SOBUE KAZUYA; AZAMI TAKAFUMI; SASANO HIROSHI; TAKEUCHI AKINORI; KATSUYA HIROTADA Nagoya medical journal 47- (3) 187 -196 2005/05
DOPAMINE AND DOBUTAMINE DID NOT IMPROVE A LOW GASTRIC INTRAMUCOSAL PH FOLLOWING CARDIOPULMONARY BYPASSITO SHOJI; SOBUE KAZUYA; AZAMI TAKAFUMI; SASANO HIROSHI; TAKEUCHI AKINORI; KATSUYA HIROTADA Nagoy...See More
SASANO Hiroshi; TSUDA Takako; TANAKA Akemi; SASANO Nobuko; KATSUYA Hirotada The Journal of the Japan Society of Pain Clinicians 10- (4) 509 -512 2003/10
A case of intractable hiccups successfully treated by baclofenSASANO Hiroshi; TSUDA Takako; TANAKA Akemi; SASANO Nobuko; KATSUYA Hirotada The Journal of the Japan Society of Pain Clinicians 10- (4)...See More
SASANO Hiroshi; TSUDA Takako; TANAKA Akemi; SASANO Nobuko; KATSUYA Hirotada The Journal of the Japan Society of Pain Clinicians 10- (4) 509 -512 2003/10
TANAKA Akemi; TSUDA Takako; TAKEUCHI Akinori; SASANO Hiroshi; MAEDA Mitsunobu The Journal of the Japan Society of Pain Clinicians 10- (1) 26 -32 2003/01
Treatment of two patients with chronic pain and drug dependence by psychotherapy in combination with nerve blockTANAKA Akemi; TSUDA Takako; TAKEUCHI Akinori; SASANO Hiroshi; MAEDA Mitsunobu The Journ...See More
TANAKA Akemi; TSUDA Takako; TAKEUCHI Akinori; SASANO Hiroshi; MAEDA Mitsunobu The Journal of the Japan Society of Pain Clinicians 10- (1) 26 -32 2003/01
SASANO Nobuko; SASANO Hiroshi; BABA Eiitsu; KATSUYA Hirotada 日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine 6- (4) 387 -391 1999/10
A case of thyroid crisis with psychiatric and neurologic manifestationsSASANO Nobuko; SASANO Hiroshi; BABA Eiitsu; KATSUYA Hirotada 日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Med...See More
SASANO Nobuko; SASANO Hiroshi; BABA Eiitsu; KATSUYA Hirotada 日本集中治療医学会雑誌 = Journal of the Japanese Society of Intensive Care Medicine 6- (4) 387 -391 1999/10
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2015/04 -2018/03
Author : SASANO HIROSHI
A study was done to safely insert a peripheral inserted central venous catheter. In the technique of real-time ultrasonic guided puncture, the factor impeding the hand eye co-operation is movement of the head during procedure, and it is necessary to establish a procedure that does not cause head movement. We presented a simple vein validation method without color Doppler for echo guided puncture. Blood reflex causing catheter related blood flow infection and catheter thrombosis was shown to occur by attaching and detaching the syringe to the needle-less connector and showed that it varies greatly depending on the type of connector.We have developed a technique to easily ultrasound guide and puncture with a new type of T-shaped probe.
Blood reflex and ultrasound guided puncture related to peripheral inserted central venous catheterJapan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scie...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2015/04 -2018/03
Author : SASANO HIROSHI
A study was done to safely insert a peripheral inserted central venous catheter. In the technique of real-time ultrasonic guided puncture, the factor impeding the hand eye co-operation is movement of the head during procedure, and it is necessary to establish a procedure that does not cause head movement. We presented a simple vein validation method without color Doppler for echo guided puncture. Blood reflex causing catheter related blood flow infection and catheter thrombosis was shown to occur by attaching and detaching the syringe to the needle-less connector and showed that it varies greatly depending on the type of connector.We have developed a technique to easily ultrasound guide and puncture with a new type of T-shaped probe.
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2013/04 -2016/03
Author : KAKO Eisuke; SASANO Hiroshi; SOBUE Kazuya
Brain white matter injury in the perioperative period of childhood has a high frequency is no cure. First, we create a brain white matter injury model using a newborn mouse. The immature brain, oligodendrocyte progenitor cells (OPC) moved to the ischemic site by cerebral ischemia, but were found not to differentiate. Therefore, we adopted the asialo-erythropoietin (EPO) as a promoting factor of differentiation. In cultured cells and brain white matter injury model, differentiation from the OPC to oligodendrocytes has been promoted by the EPO. As a treatment for white matter injury by cerebral ischemia, the moving of endogenous OPC and promoting differentiation by and EPO has a possibility of clinical application.
Elucidation of the pathogenesis of brain white matter injury caused by perioperative hypoxic ischemia and the development of regeneration therapyJapan Society for the Promotion of Science:Grants-in-Ai...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2013/04 -2016/03
Author : KAKO Eisuke; SASANO Hiroshi; SOBUE Kazuya
Brain white matter injury in the perioperative period of childhood has a high frequency is no cure. First, we create a brain white matter injury model using a newborn mouse. The immature brain, oligodendrocyte progenitor cells (OPC) moved to the ischemic site by cerebral ischemia, but were found not to differentiate. Therefore, we adopted the asialo-erythropoietin (EPO) as a promoting factor of differentiation. In cultured cells and brain white matter injury model, differentiation from the OPC to oligodendrocytes has been promoted by the EPO. As a treatment for white matter injury by cerebral ischemia, the moving of endogenous OPC and promoting differentiation by and EPO has a possibility of clinical application.
The mechanism of the development of brain edema is complex and it is not yet clear. AQP4, one of a water channel aquaporin (AQP), has been suggested the importance in the development or recovery. On the other hand, AQP9 exists in the brain; pia, hippocampus, white matter. It was found to be relatively expressed in astrocytes by detailed study. In cultured astrocytes, AQP9 expression was increased through the P38PAMK and PKA, was reduced through the PKC. Hypoxia, AQP9 decreases, expressed and re-oxygen decreased. Expression of AQP9 in the cerebral artery ligation model in rats was increased. Since the regulation mechanisms of AQP9 expression were revealed, it can be a therapeutic target in the brain edema.
Analysis of a new water channel function in the brain edema formation and development of new treatment for brain edemaJapan Society for the Promotion of Science:Grants-in-Aid for Scientific Research G...See More
The mechanism of the development of brain edema is complex and it is not yet clear. AQP4, one of a water channel aquaporin (AQP), has been suggested the importance in the development or recovery. On the other hand, AQP9 exists in the brain; pia, hippocampus, white matter. It was found to be relatively expressed in astrocytes by detailed study. In cultured astrocytes, AQP9 expression was increased through the P38PAMK and PKA, was reduced through the PKC. Hypoxia, AQP9 decreases, expressed and re-oxygen decreased. Expression of AQP9 in the cerebral artery ligation model in rats was increased. Since the regulation mechanisms of AQP9 expression were revealed, it can be a therapeutic target in the brain edema.
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2011 -2013
Author : ITO Shoji; SASANO Hiroshi
The simulator for elimination of carbon dioxide (CO2) and adsorption of oxygen (O2) was created, based on our CO2 & O2 transport model in the body. The auto end-tidal carbon dioxide & oxygen pressure (PETCO2&O2) independent control system installing the simulator was developed. The system was applied to subjects with spontaneous breathing and the PETCO2&O2 control tests were performed. In consequence the precise and independent PETCO2&O2 control method was established. We are investigating the relationships between PETCO2&O2 data and brain blood flow from BOLD fMRI image during PETCO2&O2 up & down step change in spontaneous breathing subjects.
Change of brain blood flow with BOLD MRI during expired gas contorolJapan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)Date (from‐...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2011 -2013
Author : ITO Shoji; SASANO Hiroshi
The simulator for elimination of carbon dioxide (CO2) and adsorption of oxygen (O2) was created, based on our CO2 & O2 transport model in the body. The auto end-tidal carbon dioxide & oxygen pressure (PETCO2&O2) independent control system installing the simulator was developed. The system was applied to subjects with spontaneous breathing and the PETCO2&O2 control tests were performed. In consequence the precise and independent PETCO2&O2 control method was established. We are investigating the relationships between PETCO2&O2 data and brain blood flow from BOLD fMRI image during PETCO2&O2 up & down step change in spontaneous breathing subjects.
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2003 -2004
Author : SASANO Hiroshi; ITO Shoji; HAYANO Jun-ichiro
The primary function of both the respiratory system and the cardiovascular system is to exchange oxygen and carbon dioxide been the external environment and the tissues. To achieve this, a high degree of coordination between these two systems, that is, the cardiorespiratory coordination, seems to have developed from the earliest stages of vertebrate evolution. The vagal nerve system seems to playa key role in this coordination.
Phasic activity of the cardiac vagal outflow is closely linked to respiration and produces respiratory sinus arrhythmia (RSA). It also causes increases in heart rate during inspiration and decreases during expiration, which may improve pulmonary gas exchange by matching pulmonary capillary perfusion to alveolar ventilation during each respiratory cycle. Hayano et al. demonstrated that artificially generated RSA improved the efficiency of gas exchange in vagotomized dogs due to the decrease in the ratio of physiological dead space to tidal volume (VDT phys) and the fraction of intrapuhionary shunt. On the other hand, tonic activity ofthe pulmonary vagal nerves regulates airway smooth muscle tone and hence, the anatomical dead space.
We hypothesized that both phasic cardiac vagal activity and tonic pulmonary vagal actively, estimated as respiratory sinus arrhythmia and anatomical dead space volume, respectively, contribute to improve the efficiency of pulmonary gas exchange in humans. To test this hypothesis, we examined the effect of blocking vagal nerve actively, achieved with atropine, on pulmonary gas exchange.
Ten healthy volunteers inhaled hypoxic gas with constant tidal volume and respiratory frequency through a respiratory circuit in which a respiratory analyzer was installed. Anatomical dead space (VDaw), alveolar dead space (VDalv) and the ratio of physiological dead space and tidal volume (VD/VT phys), Pao2, and oxygen saturation (Spo2) were measured. Electrocardiogram was recorded and the amplitude of R-R interval variability in the high frequency (0.15-0.2 Hz) component (RRIHF) was utilized as an index of respiratory sinus arrhythmia (RSA) magnitude.
These parameters of pulmonary function were measured before (control) and after atropine administration (0.02 mg/kg). Decreased RRIHF (P<0.01), as an index of RSA and achieved with atropine administration, was accompanied by the decrease in Pao2 and Spo2 (P<0.05, P<0.01, respectively). VDaw, VDalv, and VD/VT phys increased (P<0.01, P<0.05 and P<0.01, respectively) after atropine administration. These results were consistent with our hypothesis.
The Effect of Respiratory Sinus Arhythmia on the Pulmonary Gas Exchange Efficiency in HumansJapan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific...See More
Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2003 -2004
Author : SASANO Hiroshi; ITO Shoji; HAYANO Jun-ichiro
The primary function of both the respiratory system and the cardiovascular system is to exchange oxygen and carbon dioxide been the external environment and the tissues. To achieve this, a high degree of coordination between these two systems, that is, the cardiorespiratory coordination, seems to have developed from the earliest stages of vertebrate evolution. The vagal nerve system seems to playa key role in this coordination.
Phasic activity of the cardiac vagal outflow is closely linked to respiration and produces respiratory sinus arrhythmia (RSA). It also causes increases in heart rate during inspiration and decreases during expiration, which may improve pulmonary gas exchange by matching pulmonary capillary perfusion to alveolar ventilation during each respiratory cycle. Hayano et al. demonstrated that artificially generated RSA improved the efficiency of gas exchange in vagotomized dogs due to the decrease in the ratio of physiological dead space to tidal volume (VDT phys) and the fraction of intrapuhionary shunt. On the other hand, tonic activity ofthe pulmonary vagal nerves regulates airway smooth muscle tone and hence, the anatomical dead space.
We hypothesized that both phasic cardiac vagal activity and tonic pulmonary vagal actively, estimated as respiratory sinus arrhythmia and anatomical dead space volume, respectively, contribute to improve the efficiency of pulmonary gas exchange in humans. To test this hypothesis, we examined the effect of blocking vagal nerve actively, achieved with atropine, on pulmonary gas exchange.
Ten healthy volunteers inhaled hypoxic gas with constant tidal volume and respiratory frequency through a respiratory circuit in which a respiratory analyzer was installed. Anatomical dead space (VDaw), alveolar dead space (VDalv) and the ratio of physiological dead space and tidal volume (VD/VT phys), Pao2, and oxygen saturation (Spo2) were measured. Electrocardiogram was recorded and the amplitude of R-R interval variability in the high frequency (0.15-0.2 Hz) component (RRIHF) was utilized as an index of respiratory sinus arrhythmia (RSA) magnitude.
These parameters of pulmonary function were measured before (control) and after atropine administration (0.02 mg/kg). Decreased RRIHF (P<0.01), as an index of RSA and achieved with atropine administration, was accompanied by the decrease in Pao2 and Spo2 (P<0.05, P<0.01, respectively). VDaw, VDalv, and VD/VT phys increased (P<0.01, P<0.05 and P<0.01, respectively) after atropine administration. These results were consistent with our hypothesis.