Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Early-Career Scientists
Date (from‐to) : 2019/04 -2022/03
Author : Ishida Tomoaki
The objective of this study was to find kampo medicines that could be a potential therapeutic agent for sarcopenia in diabetic patients. First, a primary screening was conducted using in vitro assays with Sirtuin1 (Sirt1) transcriptional activity in C2C12 cells. Next, the selected herbal medicines were evaluated effect on muscle atrophy using KKAy mice, a diabetic-obese model mouse. As a result, it was found that saikokeishikankyoto and juzentaihoto alleviates muscle atrophy in KKAy mice. Furthermore, juzentaihoto also alleviated an inhibitory effect on muscle atrophy in senescence-accelerated mice (SAMP8). These results suggest that saikokeishikankyoto and juzentaihoto may have preventive effects against sarcopenia in diabetic patients.