Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2015/04 -2019/03
Author : Maeda Shinji; MAEDA tomoyo; TAMECHIKA shin-ya
Combination of mTOR inhibitor (everolimus) and IL-2 / IL-2 antibody complex (IL-2cx) therapy induced Treg cells in arthritis model mice. However, arthritis did not improve. Administration of IL-2cx to x-GVHD disease in humanized NOG mice rather exacerbated x-GVHD. It was hypothesized that Treg-resistant inflammatory cells activated by IL-2cx were present. We and analyzed effector Tcells in recipient humanized NOG mice. In IL-2cx-administered humanized NOG mice, Th1 / 17 was markedly increased.