チャップマン　オーウェン (チャップマン　オーウェン)

研究者情報

科研費研究者番号

• 21018426

ORCID ID

•  https://orcid.org/0000-0001-7923-9273

J-Global ID

• 202501014470013277

研究分野

• 情報通信 / 生命、健康、医療情報学 / がんのゲノム
• ライフサイエンス / ゲノム生物学

学歴

• 2017年09月 - 2023年07月   カリフォルニア大学サンディエゴ校   バイオメディカル情報科学科   博士
• 2013年09月 - 2017年05月   ポモナ大学   コンピュータ学科   学士

所属学協会

• 日本癌学会   Society for Neuro-Oncology   American Association for Cancer Research   

研究活動情報

論文

• Preservation and Clonal Behavior of Extrachromosomal DNA in Patient-Derived Xenograft Models of Childhood Cancers

  Rishaan Kenkre; Jon D. Larson; Owen S. Chapman; Jens Luebeck; Yan Yuen Lo; Megan Paul; Wenshu Zhang; Vineet Bafna; Robert J. Wechsler-Reya; Lukas Chavez

  2025年08月
• Extrachromosomal DNA associates with poor survival across a broad spectrum of childhood solid tumors

  Owen S. Chapman; Sunita Sridhar; Eugene Yui-Ching Chow; Rishaan Kenkre; Jonathan Kirkland; Aditi Dutta; Shanqing Wang; Wenshu Zhang; Miguel Brown; Jens Luebeck; Yan Yuen Lo; Elias Rodriguez-Fos; Anton G. Henssen; Konstantin Okonechnikov; David R. Ghasemi; Kristian W. Pajtler; Daisuke Kawauchi; Vineet Bafna; Megan Paul; Kevin Yip; Jill P. Mesirov; Lukas Chavez

  2025年07月
• Epigenetic modifications and their roles in pediatric brain tumor formation: emerging insights from chromatin dysregulation

  Kento Kawata; Owen S. Chapman; Satoshi Narumi; Daisuke Kawauchi

  Frontiers in Oncology 2025年06月
• Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression.

  Wanchen Wang; Kohei Kumegawa; Owen S Chapman; Ryo Shiraishi; Zhize Xiao; Konstantin Okonechnikov; Yang Sun; Stefan M Pfister; Weijun Feng; Naofumi Uesaka; Mikio Hoshino; Satoru Takahashi; Andrey Korshunov; Lukas Chavez; Reo Maruyama; Daisuke Kawauchi

  Cell reports 44 5 115673 - 115673 2025年05月
• Effective targeting of PDGFRA-altered high-grade glioma with avapritinib

  Lisa Mayr; Sina Neyazi; Kallen Schwark; Maria Trissal; Alexander Beck; Jenna Labelle; Sebastian K. Eder; Liesa Weiler-Wichtl; Joana G. Marques; Carlos A.O. de Biagi-Junior; Costanza Lo Cascio; Owen Chapman; Sunita Sridhar; Rishaan Kenkre; Aditi Dutta; Shanqing Wang; Jessica Wang; Olivia Hack; Andrezza Nascimento; Cuong M. Nguyen; Sophia Castellani; Jacob S. Rozowsky; Andrew Groves; Eshini Panditharatna; Gustavo Alencastro Veiga Cruzeiro; Rebecca D. Haase; Kuscha Tabatabai; Sibylle Madlener; Jack Wadden; Tiffany Adam; Seongbae Kong; Madeline Miclea; Tirth Patel; Katharina Bruckner; Daniel Senfter; Anna Lämmerer; Jeffrey Supko; Armin S. Guntner; Hana Palova; Jakub Neradil; Natalia Stepien; Daniela Lötsch-Gojo; Walter Berger; Ulrike Leiss; Verena Rosenmayr; Christian Dorfer; Karin Dieckmann; Andreas Peyrl; Amedeo A. Azizi; Alicia Baumgartner; Ondrej Slaby

  Cancer Cell 2025年03月
• Reconstructing the three-dimensional architecture of extrachromosomal DNA with ec3D

  Biswanath Chowdhury; Kaiyuan Zhu; Chaohui Li; Jens Luebeck; Owen S. Chapman; Katerina Kraft; Shu Zhang; Lukas Chavez; Anton G. Henssen; Paul S. Mischel; Howard Y. Chang; Vineet Bafna

  2025年02月
• ecPath detects ecDNA in tumors from histopathology images

  Mudra Choudhury; Lihe Liu; Anamika Yadav; Owen Chapman; Zahra Ahmadi; Raneen Younis; Chinmay Sharma; Navansh Goel; Sunita Sridhar; Rishaan Kenkre; Aditi Dutta; Shanqing Wang; Eldad Shulman; Saugato Rahman Dhruba; Danh-Tai Hoang; Kevin Tharp; Megan Paul; Denise Malicki; Kevin Yip; Eytan Ruppin; Lukas Chavez; Sanju Sinha

  2024年11月
• Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression

  Ryo Shiraishi; Gabriele Cancila; Kohei Kumegawa; Jacob Torrejon; Irene Basili; Flavia Bernardi; Patricia Benites Goncalves da Silva; Wanchen Wang; Owen Chapman; Liying Yang; Maki Jami; Kayo Nishitani; Yukimi Arai; Zhize Xiao; Hua Yu; Valentina Lo Re; Véronique Marsaud; Julie Talbot; Bérangère Lombard; Damarys Loew; Maho Jingu; Konstantin Okonechnikov; Masaki Sone; Norio Motohashi; Yoshitsugu Aoki; Stefan M. Pfister; Lukas Chavez; Mikio Hoshino; Reo Maruyama; Olivier Ayrault; Daisuke Kawauchi

  Developmental Cell 2024年09月
• Discovery of Red-Shifting Mutations in Firefly Luciferase Using High-Throughput Biochemistry.

  Colee CM; Oberlag NM; Simon M; Chapman OS; Flanagan LC; Reid-McLaughlin ES; Gewing-Mullins JA; Maiche S; Patel DF; Cavalcanti ARO; Leconte AM

  Biochemistry 2024年03月
• Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma

  Owen S. Chapman; Jens Luebeck; Sunita Sridhar; Ivy Tsz-Lo Wong; Deobrat Dixit; Shanqing Wang; Gino Prasad; Utkrisht Rajkumar; Meghana S. Pagadala; Jon D. Larson; Britney Jiayu He; King L. Hung; Joshua T. Lange; Siavash R. Dehkordi; Sahaana Chandran; Miriam Adam; Ling Morgan; Sameena Wani; Ashutosh Tiwari; Caitlin Guccione; Yingxi Lin; Aditi Dutta; Yan Yuen Lo; Edwin Juarez; James T. Robinson; Andrey Korshunov; John-Edward A. Michaels; Yoon-Jae Cho; Denise M. Malicki; Nicole G. Coufal; Michael L. Levy; Charlotte Hobbs; Richard H. Scheuermann; John R. Crawford; Scott L. Pomeroy; Jeremy N. Rich; Xinlian Zhang; Howard Y. Chang; Jesse R. Dixon; Anindya Bagchi; Aniruddha J. Deshpande; Hannah Carter; Ernest Fraenkel; Paul S. Mischel; Robert J. Wechsler-Reya; Vineet Bafna; Jill P. Mesirov; Lukas Chavez

  Nature Genetics 2023年12月
• 3D genome mapping identifies subgroup-specific chromosome conformations and tumor-dependency genes in ependymoma

  Konstantin Okonechnikov; Aylin Camgöz; Owen Chapman; Sameena Wani; Donglim Esther Park; Jens-Martin Hübner; Abhijit Chakraborty; Meghana Pagadala; Rosalind Bump; Sahaana Chandran; Katerina Kraft; Rocio Acuna-Hidalgo; Derek Reid; Kristin Sikkink; Monika Mauermann; Edwin F. Juarez; Anne Jenseit; James T. Robinson; Kristian W. Pajtler; Till Milde; Natalie Jäger; Petra Fiesel; Ling Morgan; Sunita Sridhar; Nicole G. Coufal; Michael Levy; Denise Malicki; Charlotte Hobbs; Stephen Kingsmore; Shareef Nahas; Matija Snuderl; John Crawford; Robert J. Wechsler-Reya; Tom Belle Davidson; Jennifer Cotter; George Michaiel; Gudrun Fleischhack; Stefan Mundlos; Anthony Schmitt; Hannah Carter; Kulandaimanuvel Antony Michealraj; Sachin A. Kumar; Michael D. Taylor; Jeremy Rich; Frank Buchholz; Jill P. Mesirov; Stefan M. Pfister; Ferhat Ay; Jesse R. Dixon; Marcel Kool; Lukas Chavez

  Nature Communications 2023年04月
• Inhibition of dual-specificity tyrosine phosphorylation-regulated kinase 2 perturbs 26S proteasome-addicted neoplastic progression.

  Sourav Banerjee; Tiantian Wei; Jue Wang; Jenna J Lee; Haydee L Gutierrez; Owen Chapman; Sandra E Wiley; Joshua E Mayfield; Vasudha Tandon; Edwin F Juarez; Lukas Chavez; Ruqi Liang; Robert L Sah; Caitlin Costello; Jill P Mesirov; Laureano de la Vega; Kimberly L Cooper; Jack E Dixon; Junyu Xiao; Xiaoguang Lei

  Proceedings of the National Academy of Sciences of the United States of America 116 49 24881 - 24891 2019年12月

共同研究・競争的資金等の研究課題

• Molecular drivers of pediatric tumors with extrachromosomal DNA

  日本学術振興会：科学研究費助成事業

  研究期間 : 2025年07月 -2027年03月 

  代表者 : チャップマン オーウェン
• 難治性小児脳腫瘍における染色体外DNAのクローン動態の解明

  日本学術振興会：科学研究費助成事業

  研究期間 : 2024年11月 -2027年03月 

  代表者 : 川内 大輔; CHAPMAN OWEN
• Clinical and genomic features of extrachromosomal circular DNA in pediatric cancer

  National Cancer Institute：F31 Predoctoral National Research Service Award

  研究期間 : 2022年04月 -2023年07月 

  代表者 : Owen Chapman

その他のリンク

researchmap

https://researchmap.jp/chapman-owen