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長谷川 忠男ハセガワ タダオ

所属部署医学研究科細菌学分野
職名教授
メールアドレスtadaohmed.nagoya-cu.ac.jp
ホームページURLhttp://www.med.nagoya-cu.ac.jp/micro.dir/indexJ.html
生年月日
Last Updated :2019/07/06

研究者基本情報

学歴

  • 1987年04月 - 1991年03月, 名古屋大学, 大学院医学系研究科, 内科学第一
  • 1979年04月 - 1985年03月, 名古屋大学, 医学部, 医学科

学位

  • 名古屋大学/博士(医学)

所属学協会

  • 日本細菌学会
  • 日本感染症学会
  • 日本臨床微生物学会

経歴

  • 1995-2000 国立療養所中部病院長寿医療研究センター老化機構研究部 室長
  • 2000-2005 名古屋大学大学院医学系研究科 分子病原細菌学 助教授
  • 2005- 名古屋市立大学大学院医学研究科細菌学分野 教授

研究活動情報

研究分野

  • 基礎医学, 細菌学(含真菌学)

研究キーワード

    病原細菌

論文

  • Functional predominance of msr(D), which is more effective as mef(A)-associated than mef(E)-associated, over mef(A)/mef(E) in macrolide resistance in Streptococcus pyogenes., Tatsuno I, Isaka M, Masuno K, Hata N, Matsumoto M, Hasegawa T., Microb Drug Resist.,   2018年, 査読有り
  • Female GADD34 mice develop age-related inflammation and hepatocellular carcinoma., Nishio N, Hasegawa T, Tatsuno I, Isaka M, Isobe KI., Geriatr Gerontol Int., 17, (12) 2593 - 2601,   2017年12月, 査読有り
  • Immunological aspects of age-related diseases., Isobe KI, Nishio N, Hasegawa T., World J Biol Chem. , 8, (2) 129 - 137,   2017年05月, 査読有り
  • Characterisation of clinically isolated Streptococcus pyogenes from balanoposthitis patients with special emphasis on emm89 isolates., Hasegawa T, Hata N, Matsui H, Isaka M, Tatsuno I. , J. Med. Microbiol, 66, 511 - 516,   2017年, 査読有り
  • Primary psoas abscess caused by group A streptococcus in a child: Case report with microbiologic findings., Kamiya Y, Hasegawa T, Takegami Y, Horiba K, Ando S, Torii Y, Kidokoro H, Kato T, Natsume J, Kawada J, Ito Y., J Infect Chemother. , 22, (12) 811 - 814,   2016年12月, 査読有り
  • Two-component systems involved in susceptibility to nisin A in Streptococcus pyogenes., Kawada-Matsuo M, Tatsuno I, Arii K, Zendo T, Oogai Y, Noguchi K, Hasegawa T, Sonomoto K, Komatsuzawa H., Appl. Environ. Microbiol., 82, (19) 5930 - 5939,   2016年09月, 査読有り
  • The YvqE two-component system controls biofilm formation and acid production in Streptococcus pyogenes. , Isaka M, Tatsuno I, Maeyama JI, Matsui H, Zhang Y, Hasegawa T. , APMIS, 124, (7) 574 - 585,   2016年07月, 査読有り
  • Description of the pathogenic features of Streptococcus pyogenes isolates from invasive and non-invasive diseases in Aichi, Japan., Matsumoto M, Yamada K, Suzuki M, Adachi H, Kobayashi S, Yamashita T, Minagawa H, Tatsuno I, Hasegawa T. , Jpn J Infect Dis, 69, (4) 338 - 341,   2016年07月, 査読有り
  • Relevance of spontaneous fabT mutations to a streptococcal toxic shock syndrome to non-streptococcal toxic shock syndrome transition in the novel-type Streptococcus pyogenes isolates that lost a salRK., Tatsuno I, Okada R, Matsumoto M, Hata N, Matsui H, Zhang Y, Isaka M, Hasegawa T. , APMIS, 124, (5) 414 - 424,   2016年05月, 査読有り
  • Predominant role of msr(D) over mef(A) in macrolide-resistance in Streptococcus pyogenes., Zhang Y, Tatsuno I, Okada R, Hata N, Matsumoto M, Isaka M, Isobe K, Hasegawa T., Microbiology, 162, (1) 46 - 52,   2016年01月, 査読有り
  • Analysis of the roles of NrdR and DnaB from Streptococcus pyogenes in response to host defense., Zhang Y, Okada R, Isaka M, Tatsuno I, Isobe K, Hasegawa T, APMIS, 123, (3) 252 - 259,   2015年, 査読有り
  • Emergence of type I restriction modification system-negative emm1 type Streptococcus pyogenes clinical isolates in Japan, Okada R, Matsumoto M, Zhang Y, Isaka M, Tatsuno I, Hasegawa T, APMIS, 122, (10) 914 - 921,   2014年, 査読有り
  • Simultaneous isolation of emm89-type Streptococcus pyogenes strains with a wild-type or mutated covS gene from a single streptococcal toxic shock syndrome patient, Masuno K, Okada R, Zhang Y, Isaka M, Tatsuno I, Shibata S, Hasegawa T, J. Med. Microbiol, 63, (4) 504 - 507,   2014年, 査読有り
  • Relevance of the two-component sensor protein CiaH to acid and oxidative stress responses in Streptococcus pyogenes, Tatsuno I, Isaka M, Okada R, Zhang Y, Hasegawa T, BMC Res Notes, 7, (1) ,   2014年03月, 査読有り
  • Characterization of NADase-inactive NAD+ glycohydrolase in Streptococcus pyogenes., Tatsuno I, Isaka M, Hasegawa T., Advances in Microbiology, 3, (1) 91 - 100,   2013年03月, 査読有り
  • Partial loss of CovS function in Streptococcus pyogenes causes severe invasive disease, Tatsuno I, Okada R, Zhang Y, Isaka M, Hasegawa T, BMC Res Notes, 6, (1) ,   2013年03月, 査読有り
  • Analysis of the pathological lesions of the lung in a mouse model of cutaneous infection with Streptococcus pyogenes., Minami M, Sobue S, Ichihara M, Hasegawa T., Pathol Int., 62, (2) 99 - 104,   2012年02月, 査読有り
  • The cell envelope-associated protein, LytR, regulates the cysteine protease SpeB in Streptococcus pyogenes., Minami M, Ichikawa M, Ohta M, Hasegawa T. , APMIS, 120, (5) 417 - 426,   2011年12月, 査読有り
  • 新生児および妊婦褥婦由来B群レンサ球菌の薬剤感受性と血清型―他施設共同研究1999年~2009年―, 脇本寛子、脇本幸夫、矢野久子、松原康策、宮川創平、吉田敦、奥住捷子、, 感染症学雑誌, 85, 155 - 160,   2011年, 査読有り
  • Prevalence of a Streptococcal inhibitor of a complement-mediated cell lysis-like gene (sicG) in Streptococcus dysgalactiae subsp. equisimilis. , Minami M, Ichikawa M, Matsui H, Hata N, Wakiyama N, Matsumoto M, Ohta M, Hasegawa T., Curr Microbiol., 62, 884 - 887,   2011年, 査読有り
  • Application of both high-performance liquid chromatography combined with tandem mass spectrometry shotgun and 2-D polyacrylamide gel electrophoresis for streptococcal exoproteins gave reliable proteomic data., Okamoto A, Hasegawa T, Yamada K, Ohta M, Microbiol Immunol., 55, 84 - 94,   2011年, 査読有り
  • Clinical and microbiological analysis of beta hemolytic streptococci during 2006–2010 at Nagoya City University Hospital., Ichikawa M, Minami M, Ohashi M, Wakimoto Y, Matsui H, Hasegawa T., Nagoya Med J., 51, 175 - 189,   2011年, 査読有り
  • Variation in M protein production among Streptococcus pyogenes strains according to emm genotype. , Matsumoto M, Suzuki M, Hirose K, Hiramatsu R, Minagawa H, Minami M, Tatsuno I, Okamoto A, Ohta M, Hasegawa T., Microbiol Immunol. , 55, 379 - 387,   2011年, 査読有り
  • Protective effect of Hainosankyuto, a traditional Japanese medicine, on Streptococcus pyogenes infection in murine model. , Minami M, Ichikawa M, Hata N, Hasegawa T., PLoS One., 6, (7) ,   2011年, 査読有り
  • Analysis of two-component sensor proteins involved in response to acid stimuli in Streptococcus pyogenes., Ichikawa M, Minami M, Isaka M, Tatsuno I, Hasegawa T., Microbiology, 157, 3187 - 3194,   2011年, 査読有り
  • Evaluation of selection media for the detection of borderline MRSA., Yamada K, Inuzuka K, Tatsumi N, Sanzen I, Ohkura T, Okamoto A, Hasegawa T, Ohta M. , J Infect Chemother., 16, 19 - 24,   2010年, 査読有り
  • Clindamycin-induced CovS-mediated regulation of the production of virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes., Minami M, Kamimura T, Isaka M, Tatsuno I, Ohta M, Hasegawa T., Antimicrob Agents Chemother. , 54, 98 - 102,   2010年, 査読有り
  • Characterization of Streptococcus pyogenes isolated from balanoposthitis patients presumably transmitted by penile-oral sexual intercourse. , Minami M, Wakimoto Y, Matsumoto M, Matsui H, Kubota Y, Okada A, Isaka M, Tatsuno I, Tanaka Y, Hasegawa T. , Curr Microbiol, 61, 101 - 105,   2010年, 査読有り
  • NADase as a target molecule of in vivo suppression of the toxicity in the invasive M-1 group A Streptococcal isolates., Tatsuno I, Isaka M, Minami M, Hasegawa T., BMC Microbiol., 10,   2010年, 査読有り
  • Detection of invasive protein profile of Streptococcus pyogenes M1 isolates from pharyngitis patients., Hasegawa T, Okamoto A, Kamimura T, Tatsuno I, Hashikawa S, Yabutani M, Matsumoto M, Yamada K, Isaka M, Minami M, Ohta M., APMIS, 118, 167 - 178,   2010年, 査読有り
  • Characterization of a virulence-associated and cell-wall-located DNase of Streptococcus pyogenes., Hasegawa T, Minami M, Okamoto A, Tatsuno I, Isaka M, Ohta M, Microbiology, 156, 184 - 190,   2010年, 査読有り
  • Variations in amount of TSST-1 produced by clinical methicillin resistant Staphylococcus aureus (MRSA) isolates and allelic variation in accessory gene regulator (agr) locus., Nagao M, Okamoto A, Yamada K, Hasegawa T, Hasegawa Y, Ohta M., BMC Microbiol., 9,   2009年, 査読有り
  • Seroprevalence of Fusobacterium varium in ulcerative colitis patients in Japan. , Minami M, Ando T, Okamoto A, Sasaki N, Ohkura T, Torii K, Hasegawa T, Ohta M, Goto H., FEMS Immunol Med Microbiol. , 56, 67 - 72,   2009年, 査読有り
  • Nationwide epidemiological study revealed the dissemination of methicillin-resistant Staphylococcus aureus carrying a specific set of virulence-associated genes in Japanese hospitals., Ohkura T, Yamada K, Okamoto A, Baba H, Ike Y, Arakawa Y, Hasegawa T, Ohta M. , J Med Microbiol., 58, 1329 - 1336,   2009年, 査読有り
  • Transmission of bacterial infections to healthcare workers during intubation and respiratory care of patients with severe pneumonia. , Baba H, Iinuma Y, Imaizumi K, Hasegawa Y, Hasegawa T, Ohta M, Paterson DL. , Infect Control Hosp Epidemiol. , 30, 1019 - 1021,   2009年, 査読有り
  • Effect of cyclic bis(3'-5') diguanylic acid and its analogs on bacterial biofilm formation., Ishihara Y, Hyodo M, Hayakawa Y, Kamegaya T, Yamada K, Okamoto A, Hasegawa T, Ohta M. , FEMS Microbiol Lett, 301, 193 - 200,   2009年, 査読有り
  • The streptococcal inhibitor of complement (SIC) protects Streptococcus pyogenes from bacteriocin-like inhibitory substance (BLIS) from Streptococcus salivarius. , Minami M, Ohmori D, Tatsuno I, Isaka M, Kawamura Y, Ohta M, Hasegawa T., FEMS Microbiol Lett., 298, 67 - 73,   2009年, 査読有り
  • Protective effect of nasal immunization of influenza virus hemagglutinin with recombinant cholera toxin B subunit as a mucosal adjuvant in mice. , Isaka M, Zhao Y, Nobusawa E, Nakajima S, Nakajima K, Yasuda Y, Matsui H, Hasegawa T, Maeyama J, Morokuma K, Ohkuma K, Tochikubo K. , Microbiol Immunol., 52, 55 - 63,   2008年, 査読有り
  • Analysis of twin-arginine translocation pathway homologue in Staphylococcus aureus., Yamada K, Sanzen I, Ohkura T, Okamoto A, Torii K, Hasegawa T, Ohta M. , Curr Microbiol., 55, 14 - 19,   2007年, 査読有り
  • A new phylogenetic cluster of cereulide-producing Bacillus cereus strains. , Vassileva M, Torii K, Oshimoto M, Okamoto A, Agata N, Yamada K, Hasegawa T, Ohta M. , J Clin Microbiol., 45, 1274 - 1277,   2007年, 査読有り
  • Post-colonoscopic Listeria septicemia in ulcerative colitis during immunosuppressive therapy. , Minami M, Hasegawa T, Ando T, Maeda O, Ohkura T, Ohta M, Goto H. , Intern Med., 46, 2023 - 2027,   2007年, 査読有り
  • Growth phase dependent effect of clindamycin on production of exoproteins by Streptococcus pyogenes. , Sawai J, Hasegawa T, Kamimura T, Okamoto A, Ohmori D, Nosaka N, Yamada K, Torii K, Ohta M. , Antimicrob Agents Chemother. , 51, 461 - 467,   2007年, 査読有り
  • Characterization of the NAD-glycohydrolase in Streptococcal strains., Tatsuno I, Sawai J, Okamoto A, Matsumoto M, Minami M, Isaka M, Ohta M, Hasegawa T., Microbiology , 153, 4253 - 4260,   2007年, 査読有り
  • Phylogenetic analysis of Bacillus cereus isolates from severe systemic infections using multilocus sequence typing scheme. , Vassileva M, Torii K, Oshimoto M, Okamoto A, Agata N, Yamada K, Hasegawa T, Ohta M. , Microbiol Immunol. , 50, 743 - 749,   2006年, 査読有り
  • Use of a combination of brushing technique and the loop-mediated isothermal amplification method as a novel, rapid, and safe system for detection of Helicobacter pylori. , Minami M, Ohta M, Ohkura T, Ando T, Torii K, Hasegawa T, Goto H. , J Clin Microbiol., 44, 4032 - 4037,   2006年, 査読有り
  • 劇症型感染症を引き起こすA群レンサ球菌の時代変遷に伴う遺伝子変異と病原性との関連, 長谷川 忠男, 名古屋市立大学医学会雑誌, 56, 107 - 111,   2005年
  • Quantitative analysis of cereulide, an emetic toxin of Bacillus cereus, by using rat liver mitochondria. , Kawamura-Sato K, Hirama Y, Agata N, Ito H, Torii K, Takeno A, Hasegawa T, Shimomura Y, Ohta M. , Microbiol Immunol , 49, 25 - 30,   2005年, 査読有り
  • Prevalence of Ile-460-Val/ParE substitution in clinical Streptococcus pneumoniae isolates that were less susceptible to fluoroquinolones., Kawamura-Sato K, Hasegawa T, Torii K, Ito H, Ohta M., Curr Microbiol. , 51, 27 - 30,   2005年, 査読有り
  • Effect of antibiotics on group A streptococcus exoprotein production analyzed by two-dimensional gel electrophoresis., Tanaka M, Hasegawa T, Okamoto A, Torii K, Ohta M., Antimicrob Agents Chemother, 49, 88 - 96,   2005年, 査読有り
  • Close correlation of Streptococcal DNase B (sdaB) alleles with emm genotypes in Streptococcus pyogenes. , Matsumoto M, Sakae K, Hashikawa S, Torii K, Hasegawa T, Horii T, Endo M, Okuno R, Murayama S, Hirasawa K, Suzuki R, Isobe J, Tanaka D, Katsukawa C, Tamaru A, Tomita M, Ogata K, Ikebe T, Watanabe H, The Working Group for Group A Streptococci in Japan, Ohta M. , Microbiol Immunol., 49, 925 - 929,   2005年, 査読有り
  • 劇症型レンサ球菌感染症の臨床~全国アンケートの結果も含めて~, 長谷川 忠男, 感染防止, 14, 1 - 7,   2004年, 招待有り
  • Regulation of mouse GADD34 gene transcription after DNA damaging agent methylmethane sulfonate. , Haneda M, Xiao H, Hasegawa T, Kimura Y, Nakashima I, Isobe K. , Gene, 336, 139 - 146,   2004年, 査読有り
  • Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53. , Haneda M, Kojima E, Nishikimi A, Hasegawa T, Nakashima I, Isobe K. , FEBS Lett, 567, 171 - 174,   2004年, 査読有り
  • Effect of glycine on Helicobacter pylori in vitro., Minami M, Ando T, Hashikawa SN, Torii K, Hasegawa T, Israel DA, Ina K, Kusugami K, Goto H, Ohta M., Antimicrob Agents Chemother, 48, 3782 - 3788,   2004年, 査読有り
  • Characterization of group C and G streptococcal strains that cause streptococcal toxic shock syndrome., Hashikawa S, Iinuma Y, Furushita M, Ohkura T, Nada T, Torii K, Hasegawa T, Ohta M. , J Clin Microbiol , 42, 186 - 192,   2004年, 査読有り
  • Two-dimensional gel electrophoresis analysis of the abundance of virulent exoproteins of group A streptococcus caused by environmental changes., Nakamura T, Hasegawa T, Torii K, Hasegawa Y, Shimokata K, Ohta M., Arch Microbiol, 181, 74 - 81,   2004年, 査読有り
  • Factors determining prognosis in streptococcal toxic shock-like syndrome: results of a nationwide investigation in Japan., Hasegawa T, Hashikawa S, Nakamura T, Torii K, Ohta M. , Microbes Infect, 6, 1073 - 1077,   2004年, 査読有り
  • Helicobacter pylori (H. pylori)の病原因子に対するクラリスロマイシン(CAM)の影響, 野畑和夫、太田美智男、長谷川忠男、都築智之、安藤貴文、伊奈研次、楠神和男、後藤秀美, 化学療法の領域, 19, 112 - 117,   2003年
  • 劇症型レンサ球菌感染症(人喰いバクテリア), 長谷川 忠男, 現代医学, 51, 243 - 251,   2003年, 招待有り
  • Similarity of tetracycline resistance genes isolated from fish farm bacteria to those from clinical isolates., Furushita M, Shiba T, Maeda T, Yahata M, Kaneoka A, Takahashi Y, Torii K, Hasegawa T, Ohta M., Appl Environ Microbiol, 69, 5336 - 5342,   2003年, 査読有り
  • GADD34 induces p53 phosphorylation and p21/WAF1 transcription. , Yagi A, Hasegawa Y, Xiao H, Haneda M, Kojima E, Nishikimi A, Hasegawa T, Shimokata K, Isobe K. , J Cell Biochem, 90, 1242 - 1249,   2003年, 査読有り
  • Evaluation of automated ribotyping system for characterization and identification of verocytotoxin-producing Escherichia coli isolated in Japan., Ito Y, Iinuma Y, Baba H, Sugino Y, Hasegawa Y, Shimokata K, Ichiyama S, Hasegawa T, Ohta M. , Jpn J Infect Dis , 56, 200 - 204,   2003年, 査読有り
  • Heterozygosity with respect to Zfp148 causes complete loss of fetal germ cells during mouse embryogenesis. , Takeuchi A, Mishina Y, Miyaishi O, Kojima E, Hasegawa T, Isobe K., Nat Genet, 33, 172 - 176,   2003年, 査読有り
  • The function of GADD34 is a recovery from a shutoff of protein synthesis induced by ER stress: elucidation by GADD34-deficient mice. , Kojima E, Takeuchi A, Haneda M, Yagi A, Hasegawa T, Yamaki K, Takeda K, Akira S, Shimokata K, Isobe K., FASEB J, 17, 1573 - 1575,   2003年, 査読有り
  • Involvement of surface polysaccharides in the organic acid resistance of Shiga Toxin-producing Escherichia coli O157:H7. , Barua S, Yamashino T, Hasegawa T, Yokoyama K, Torii K, Ohta M. , Mol Microbiol, 43, 629 - 640,   2002年, 査読有り
  • Genomic cloning and promoter analysis of the GAHSP40 gene., Hamajima F, Hasegawa T, Nakashima I, Isobe K., J Cell Biochem, 84, 401 - 407,   2002年, 査読有り
  • Two-dimensional analysis of exoproteins of methicillin-resistant Staphylococcus aureus (MRSA) for possible epidemiological applications. , Nakano M, Kawano Y, Kawagishi M, Hasegawa T, Iinuma Y, Ohta M. , Microbiol Immunol , 46, 11 - 22,   2002年, 査読有り
  • An outbreak of neonatal toxic shock syndrome-like exanthematous disease (NTED) caused by methicillin-resistant Staphylococcus aureus (MRSA) in a neonatal intensive care unit. , Nakano M, Miyazawa H, Kawano Y, Kawagishi M, Torii K, Hasegawa T, Iinuma Y, Ohta M. , Microbiol Immunol, 46, 277 - 284,   2002年, 査読有り
  • Clarithromycin increases the release of heat shock protein B from Helicobacter pylori. , Tsuzuki T, Ina K, Ohta M, Hasegawa T, Nagasaka T, Saburi N, Ueda M, Konagaya T, Kaneko H, Imada A, Nishiwaki T, Nobata K, Ando T, Kusugami K., Aliment Pharmacol Ther , 16, 217 - 228,   2002年, 査読有り
  • Cloning and characterization of the deoxyribonuclease sda gene from Streptococcus pyogenes., Hasegawa T, Torii K, Hashikawa S, Iinuma Y, Ohta M. , Curr Microbiol, 45, 13 - 17,   2002年, 査読有り
  • Cloning and characterization of two novel DNases from Streptococcus pyogenes. , Hasegawa T, Torii K, Hashikawa S, Iinuma Y, Ohta M. , Arch Microbiol , 177, 451 - 456,   2002年, 査読有り
  • Proteolytic cleavage of staphylococcal exoproteins analyzed by two-dimensional gel electrophoresis. , Kawano Y, Kawagishi M, Nakano M, Mase K, Yamashino T, Hasegawa T, Ohta M. , Microbiol Immunol , 45, 285 - 290,   2001年, 査読有り
  • Postantibiotic suppression effect of macrolides on the expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis., Kawamura-Sato K, Iinuma Y, Hasegawa T, Yamashino T, Ohta M. , J Infect Chemother, 7, 51 - 54,   2001年, 査読有り
  • Resolution of Escherichia coli O157:H7 that contaminated radish sprouts in two outbreaks by two-dimensional gel electrophoresis., Yokoyama K, Iinuma Y, Kawano Y, Nakano M, Kawagishi M, Yamashino T, Hasegawa T, Ohta M. , Curr Microbiol, 43, 311 - 315,   2001年, 査読有り
  • Interaction between GADD34 and kinesin superfamily, KIF3A. , Hasegawa T, Yagi A, Isobe K. , Biochem Biophys Res Commun, 267, 593 - 596,   2000年, 査読有り
  • PTRF (polymerase I and transcript-release factor) is tissue-specific and interacts with the BFCOL1 (binding factor of a type-I collagen promoter) zinc-finger transcription factor which binds to the two mouse type-I collagen gene promoters. , Hasegawa T, Takeuchi A, Miyaishi O, Xiao H, Mao J, Isobe K. , Biochem J., 347, 55 - 59,   2000年, 査読有り
  • The staphylokinase gene is located in the structural gene encoding N-acetylmuramyl-L-alanine amidase in methicillin-resistant Staphylococcus aureus. , Horii T, Yokoyama K, Barua S, Odagiri T, Futamura N, Hasegawa T, Ohta M. , FEMS Microbiol Lett, 185, 221 - 224,   2000年, 査読有り
  • A NF-kB p65 subunit is indispensable for activating manganese superoxide: dismutase gene transcription mediated by tumor necrosis factora-., Maehara K, Hasegawa T, Isobe K. , J Cell Biochem, 77, 474 - 486,   2000年, 査読有り
  • Characterization of a murine gene encoding an acidic-basic dipeptide repeat that interacts with GADD34., Hasegawa T, Isobe K. , J Cell Biochem, 77, 596 - 603,   2000年, 査読有り
  • Rapid isolation and identification of staphylococcal exoproteins by reverse phase capillary high performance liquid chromatography-electrospray ionization mass spectrometry., Kawano Y, Ito Y, Yamakawa Y, Yamashino T, Horii T, Hasegawa T, Ohta M. , FEMS Microbiol. Lett , 189, 103 - 108,   2000年, 査読有り
  • Firm adherence of Staphylococcus aureus and Staphylococcus epidermidis to human hair and effect of detergent treatment., Mase K, Hasegawa T, Horii T, Hatakeyama K, Kawano Y, Yamashino T, Ohta M. , Microbiol Immunol, 44, 653 - 656,   2000年, 査読有り
  • Effect of subinhibitory concentrations of macrolides on expression of flagellin in Pseudomonas aeruginosa and Proteus mirabilis., Kawamura-Sato K, Iinuma Y, Hasegawa T, Horii T, Yamashino T, Ohta M. , Antimicrob Agents Chemother , 44, 2869 - 2872,   2000年, 査読有り
  • Production of shiga toxin by Escherichia coli measured with reference to the membrane vesicle-associated toxins. , Yokoyama K, Horii T, Yamashino T, Hashikawa S, Barua S, Hasegawa T, Watanabe H, Ohta M., FEMS Microbiol Lett , 192, 139 - 144,   2000年, 査読有り
  • Interaction between DNA-damage protein GADD34 and a new member of the Hsp40 family of heat shock proteins that is induced by a DNA-damaging reagent., Hasegawa T, Xiao H, Hamajima F, Isobe K. , Biochem J , 352, 795 - 800,   2000年, 査読有り
  • p300 collaborates with Sp1 and Sp3 in p21waf1/cip1 promoter activation induced by histone deacetylase inhibitor. , Xiao H, Hasegawa T, Isobe K., J Biol Chem, 275, 1371 - 1376,   2000年, 査読有り
  • Fatal rapidly progressing streptococcal toxic shock-like syndrome; case report. , Yokota M, Hasegawa T, Ohta M, Satake T., Jpn J Infect Dis, 53, 81 - 82,   2000年, 査読有り
  • Both Sp1 and Sp3 are responsible for p21waf1 promoter activity induced by histone deacetylase inhibitor in NIH3T3 cells., Xiao H, Hasegawa T, Isobe K., J Cell Biochem , 73, 291 - 302,   1999年, 査読有り
  • Cloning of a GADD34-like gene that interacts with the zinc-finger transcription factor which binds to the p21WAF promoter. , Hasegawa T, Xiao H, Isobe K., Biochem Biophys Res Commun, 256, 249 - 254,   1999年, 査読有り
  • Cooperative interaction of NF-B and C/EBP binding sites is necessary for manganese superoxide dismutase gene transcription mediated by lipopolysaccharide and interferon-. , Maehara K, Hasegawa T, Xiao H, Takeuchi A, Abe R, Isobe K. , FEBS Lett , 449, 115 - 119,   1999年, 査読有り
  • Evidence for the interaction between Translin and GADD34 in mammalian cells., Hasegawa T, Isobe K., Biochim Biophys Acta, 1428, 161 - 168,   1999年, 査読有り
  • 線維化疾患とI型コラーゲン遺伝子発現, 長谷川 忠男, 現代医学, 46, 147 - 152,   1998年, 招待有り
  • 加齢とアポトーシス, 磯部健一、武内章英、長谷川忠男、大楠晃三, 臨床免疫, 29, 1422 - 1426,   1997年
  • Sodium butyrate induces NIH3T3 cells to senescence-like state and enhances promoter activity of p21WAF/CIP1 in p53-independent manner. , Xiao H, Hasegawa T, Miyaishi O, Ohkusu K, Isobe K. , Biochem Biophys Res Commun , 237, 457 - 460,   1997年, 査読有り
  • Cloning and characterization of a transcription factor that binds to the proximal promoters of the two mouse type I collagen genes. , Hasegawa T, Takeuchi A, Miyaishi O, Isobe K, de Crombrugghe B., J Biol Chem, 272, 4915 - 4923,   1997年, 査読有り
  • Evidence for three major transcription activation elements in the proximal mouse proa2(I) collagen promoter., Hasegawa T, Zhou X, Garrett LA, Ruteshouser EC, Maity SN, de Crombrugghe B. , Nucleic Acids Res, 24, 3253 - 3260,   1996年, 査読有り
  • CEA ファミリー, 下方 薫,長谷川忠男, 生体の科学, 46, 646 - 648,   1995年
  • Nonspecific crossreacting antigen (NCA) is a major member of the carcinoembryonic antigen (CEA)-related gene family expressed in lung cancer. , Hasegawa T, Isobe K, Tsuchiya Y, Oikawa S, Nakazato H, Nakashima I, Shimokata K. , Br J Cancer, 67, 58 - 65,   1993年, 査読有り
  • Expression of carcinoembryonic antigen (CEA) and nonspecific crossreacting antigen (NCA) in gastrointestinal cancer; the correlation with degree of differentiation. , Kodera Y, Isobe K, Yamauchi M, Satta T, Hasegawa T, Oikawa S, Kondoh K, Akiyama S, Itoh K, Nakashima I, Takagi H. , Br J Cancer, 68, 130 - 136,   1993年, 査読有り
  • Gene transfer of herpes simplex virus type I thymidine kinase gene as a drug sensitivity gene into human lung cancer cell lines using retroviral vectors., Hasegawa Y, Emi N, Shimokata K, Abe A, Kawabe T, Hasegawa T, Kirioka T, Saito H. , Am J Respir Cell Mol Biol, 8, 655 - 661,   1993年, 査読有り
  • Higher expression of topoisomerase II in lung cancers than normal lung tissues: different expression pattern from topoisomerase I. , Hasegawa T, Isobe K, Nakashima I, Shimokata K. , Biochem Biophys Res Commun , 195, 409 - 414,   1993年, 査読有り
  • Quantitative analysis of antigen for the induction of tolerance in carcinoembryonic antigen transgenic mice., Hasegawa T, Isobe K, Nakashima I, Shimokata K., Immunology, 77, 577 - 581,   1992年, 査読有り
  • Cytokine content in pleural effusion. Comparison between tuberculous and carcinomatous pleurisy., Shimokata K, Saka H, Murate T, Hasegawa Y, Hasegawa T. , Chest , 99, 1103 - 1107,   1991年, 査読有り
  • Modulation of the secondary antibody response of murine lymphocytes to sheep red blood cells in vitro by neuraminidase and exoglycosidases. , Nakamura M, Yoshida T, Isobe K, Iwamoto T, Rahman SMJ, Zhang YH, Hasegawa T, Ichihara M, Nakashima I., Immunol Lett, 29, 235 - 240,   1991年, 査読有り
  • Establishment and characterisation of human carcinoembryonic antigen transgenic mice., Hasegawa T, Isobe K, Tsuchiya Y, Oikawa S, Nakazato H, Ikezawa H, Nakashima I, Shimokata, K., Br J Cancer, 64, 710 - 714,   1991年, 査読有り
  • 肝外性の閉塞性黄疸を主徴とし,脊髄髄内転移巣からの出血で死亡した肺小細胞癌の1剖検例 , 村手孝直, 長谷川忠男, 長谷川好規, 下方 薫, 日本胸部疾患学会雑誌, 27, 513 - 517,   1989年, 査読有り
  • Enzyme-linked immunosorbent assay for the differential diagnosis of pulmonary tuberculosis and pulmonary diseases due to Mycobacterium avium-intracellulare complex., Amano H, Mizoguchi K, Tsukamura M, Murate T, Hasegawa T, Shimokata K. , Jpn J Med, 28, 196 - 201,   1989年, 査読有り
  • Induction of antitumor immunity in mice by allo-major histocompatibility complex class I gene transfectant with strong antigen expression. , Isobe K, Hasegawa Y, Iwamoto T, Hasegawa T, Kawashima K, Ding L, Nakashima, I. , J Natl Cancer Inst, 81, 1823 - 1828,   1989年, 査読有り
  • Rat mesangial cells actively produce phosphatidylinositol-anchored Thy-1., Miyata T, Isobe K, Inagi R, Taguchi R, Ikezawa H, Takai I, Fujita Y, Iwamoto T, Hasegawa T, Oda O, Yamanaka N, Sugiyama S, Maeda K. , Immunology, 67, 531 - 533,   1989年, 査読有り
  • Induction and characterization of minor histocompatibility antigens. specific primary cytotoxic T lymphocyte responses in vitro., Ando K, Nakashima I, Nagase F, Isobe K, Kawashima K, Hasegawa Y, Yoshida T, Iwamoto T, Hasegawa T, Muro Y, Ohashi M. , J Immunol , 140, 723 - 729,   1988年, 査読有り
  • Genetic and stimulator cell requirements for generation and activation of minor histocompatibility antigen-specific memory cytotoxic T-lymphocyte precursors., Ando K, Isobe K, Hasegawa T, Iwamoto T, Ding R, Rahman J, Muro Y, Yoshida T, Nagase F, Kawashima K, Ohashi M, Nakashima I., Immunology, 64, 661 - 667,   1988年, 査読有り
  • Further evidence for H-2-unrestricted induction of minor histocompatibility antigens-specific T cell immunity in vivo., Mizoguchi K, Isobe K, Yoshida T, Iwamoto T, Hasegawa T, Ding L, Rahman SMJ, Miyata T, Nagase F, Shimokata K, Kawashima K, Nakashima I., Immunol Lett, 19, 41 - 47,   1988年, 査読有り
  • Biphasic radiation-sensitivity of the transplantation immunity for rejection of an allogenic ascites tumor., Hasegawa Y, Nakashima I, Mizoguchi K, Nagase F, Isobe K, Shimokata K, Kawashima K, Ando K, Yoshida T, Iwamoto T, Hasegawa T. , Immunobiology, 177, 120 - 133,   1988年, 査読有り
  • Ontogeny of the transplantation immunity of mice for rejecting ascitic allogeneic tumors., Ando K, Hasegawa T, Nakashima I, Mizoguchi K, Isobe K, Nagase F, Kawashima K, Kato N, Ohashi K., Dev Comp Immunol , 9, 701 - 708,   1985年, 査読有り
  • Direct activation of Sendai virus (HVJ)-specific cell-mediated immunity of mice for second set rejection of the virus-infected syngeneic tumor by noninfectious virus-sensitized spleen cells., Kamihira O, Nakashima I, Hasegawa T, Ando K, Isobe K, Nagase F, Hasegawa Y, Yoshida T, Kawashima K, Yoshida T, Yokochi T. , Immunol Lett, 11, 75 - 81,   1985年, 査読有り

競争的資金

  • ファージ由来DNAに注目したA群レンサ球菌のマクロライド耐性機構と病原性の解明, 日本学術振興会, 基盤研究(C),   2016年04月 - 2019年03月, 長谷川 忠男
  • A群レンサ球菌における二成分制御系センサー蛋白質のネットワークの解明に関する研究, 日本学術振興会, 基盤研究(C),   2012年04月 - 2015年03月, 長谷川 忠男
  • A群レンサ球菌における糖輸送系蛋白質発現制御因子と病原性に関する研究, 日本学術振興会, 基盤研究(C),   2009年04月 - 2012年03月, 長谷川 忠男
  • A群レンサ球菌毒素蛋白質発現機構の網羅的解明とその制御に関する研究, 日本学術振興会, 基盤研究(C),   2004年04月 - 2006年03月, 長谷川 忠男

教育活動情報

担当経験のある科目

  • 細菌学, 名古屋市立大学、名古屋大学

社会貢献活動情報

社会貢献活動

  • 愛知県衛生研究所運営委員会委員, 助言・指導, 行政,   2006年08月 - 現在, 愛知県衛生研究所運営委員会への出席
  • 名古屋市衛生研究所調査研究協議会委員, 助言・指導, 行政,   2006年08月 - 2018年08月, 調査研究事項の審議
  • 名古屋市立大学 医・薬・看連携研究事業にて講演会を実施, 企画, 名古屋市立大学,   2011年08月 - 2013年03月, 介護施設従事者を対象に講演会等の実施
  • 論文査読, その他, その他,   2006年10月 - 現在, 学術雑誌投稿論文の査読


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