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松川 則之マツカワ ノリユキ

所属部署医学研究科神経内科学分野
職名教授
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Last Updated :2020/06/03

研究者基本情報

学位

  • 名古屋市立大学医学研究科内科学/博士(医学)

所属学協会

  • 認知症学会
  • 日本神経科学会
  • 日本神経治療学会
  • 日本神経化学会
  • 日本神経学会
  • 日本内科学会

研究活動情報

研究分野

  • ライフサイエンス, 神経科学一般
  • ライフサイエンス, 神経科学一般
  • ライフサイエンス, 神経内科学

研究キーワード

    脳虚血, パーキンソン病, アルツハイマー病

論文

  • Corticobasal syndrome-Pick's disease: A clinicopathological study., Yuto Uchida, Mari Yoshida, Koji Takada, Yasukuni Tsugu, Yoshino Ueki, Noriyuki Matsukawa, Journal of the neurological sciences, 412, 116752 - 116752,   2020年02月19日, 査読有り
  • Simultaneous voxel-based magnetic susceptibility and morphometry analysis using magnetization-prepared spoiled turbo multiple gradient echo, Kan, Hirohito, Uchida, Yuto, Arai, Nobuyuki, Ueki, Yoshino, Aoki, Toshitaka, Kasai, Harumasa, Kunitomo, Hiroshi, Hirose, Yasujiro, Matsukawa, Noriyuki, Shibamoto, Yuta, NMR IN BIOMEDICINE,   2020年02月, 査読有り, This study aimed to develop and test a simultaneous acquisition and analysis pipeline for voxel-based magnetic susceptibility and morphometry (VBMSM) on a single dataset using young volunteers, elderly healthy volunteers, and an Alzheimer's disease (AD) group. 3D T-1-weighted and multi-echo phase images for VBM and quantitative susceptibility mapping (QSM) were simultaneously acquired using a magnetization-prepared spoiled turbo multiple gradient echo sequence with inversion pulse for QSM (MP-QSM). The magnitude image was split into gray matter (GM) and white matter (WM) and was spatially normalized. The susceptibility map was reconstructed from the phase images. The segmented image and susceptibility map were compared with those obtained from conventional multiple spoiled gradient echo (mGRE) and MP-spoiled gradient echo (MP-GRE) in healthy volunteers to validate the availability of MP-QSM by numerical measurements. To assess the feasibility of the VBMSM analysis pipeline, voxel-based comparisons of susceptibility and morphometry in MP-QSM were conducted in volunteers with a bimodal age distribution, and in elderly volunteers and the AD group, using spatially normalized GM and WM volume images and a susceptibility map. GM/WM contrasts in MP-QSM, MP-GRE, and mGRE were 0.14 +/- 0.011, 0.17 +/- 0.015, and 0.045 +/- 0.010, respectively. Segmented GM and WM volumes in the MP-QSM closely coincided with those in the MP-GRE. Region of interest analyses indicated that the mean susceptibility values in MP-QSM were completely in agreement with those in mGRE. In an evaluation of the aging effect, a significant increase and decrease in susceptibility and volume were found by VBMSM in deep GM and WM, respectively. Between the elderly volunteers and the AD group, the characteristic susceptibility and volume changes in GM and WM were observed. The proposed MP-QSM sequence makes it possible to acquire acceptable-quality images for simultaneous analysis and determine brain atrophy and susceptibility distribution without image registration by using voxel-based analyses.
  • Motor learning requires myelination to reduce asynchrony and spontaneity in neural activity, Kato D, Wake H, Lee PR, Tachibana Y, Ono R, Sugio S, Tsuji Y, Tanaka YH, Tanaka TR, Masamizu Y, Hira R, Moorhouse AJ, Tamamaki N, Ikenaka K, Matsukawa N, Field RD, Nabekura J, Matsuzaki M, Glia, 68, (1) 193 - 210,   2020年, 査読有り
  • Reduced cholinergic activity in the hippocampus of Hippocampal cholinergic neurostimulating peptide precursor protein knockout mice., Madokoro Y, Yoshino Y, Kato D, Sato T, Mizuno M, Kanamori T, Shimazawa M, Hida H, Hara H, Yoshida M, Borlongan CV, Ojika K, Matsukawa N, Int J Mol Sci., 20, (21) ,   2019年, 査読有り
  • Nigrostriatal Dopaminergic Dysfunction and Altered Functional Connectivity in REM sleep Behaviour Disorder with Mild Motor Impairment., Yamada G, Ueki Y, Oishi N, Oguri T, Fukui A, Nakayama M, Kandori A, Sano Y, Kan H, Arai N, Sakurai K, Wada I, Matsukawa N, Frontier in Neurology, 10,   2019年, 査読有り
  • Impaired motor skill acquisition using mirror visual feedback improved by transcranial direct current stimulation (tDCS) in patients with Parkinson’s disease., Horiba M, Ueki Y, Nojiri I, Shimizu Y, Sahashi K, Itamoto S, Suzuki A, Yamada G, Matsukawa N, Wada I, Frontier in Neurosci., 13,   2019年, 査読有り
  • Voxel-based quantitative susceptibility mapping in Parkinson's disease with mild cognitive impairment., Uchida Y, Kan H, Sakurai K, Arai N, Kato D, Kawashima S, Ueki Y, Matsukawa N, Mov Disord., 34, (8) 1164 - 1173,   2019年, 査読有り
  • Tongue base retraction and airway obstruction in drug-induced oromandibular dystonia., Yamada G, Ueki Y, Okita K, Matsukawa N, Neurology, 92, (18) ,   2019年, 査読有り
  • Anatomical Links between White Matter Hyperintensity and Medial Temporal Atrophy Reveal Impairment of Executive Functions, Yamanaka T, Uchida Y, Sakurai K, Kato D, Mizuno M, Sato T, Madokoro Y, Kondo Y, Suzuki A, Ueki Y, Ishii F, Borlongan CV, Matsukawa N, Aging and Disease, 10, (4) 711 - 718,   2019年, 査読有り
  • Characteristic asymmetric limbic and anterior temporal atrophy in demented patients with pathologically confirmed argyrophilic grain disease., Sakurai K, Tokumaru A.M, Ikeda T, Morimoto S, Inui S, Sumida K, Oba H, Nakagawa M, Matsukawa N, Hashizume Y, Neuroradiology, 61, (11) 1230 - 1249,   2019年, 査読有り
  • The pathological features of MOG antibody-positive cerebral cortical encephalitis as a new spectrum associated with MOG antibodies: A case report., Ikeda T, Yamada K, Ogawa R, Takai Y, Kaneko K, Misu T, Kamimoto K, Matsukawa N, Yoshida M, J Neurol Sci., 15, (392) 113 - 115,   2018年, 査読有り
  • Reduced striatal dopaminergic release during motor skill acquisition in Parkinson’s disease., Kawashima S, Ueki Y, Kato D, Ito K, Matsukawa N, PLoS One, 13, (5) ,   2018年, 査読有り
  • Development of paradoxical cerebral embolization during lymphatic draining massage: A case report., Oomura M, Fujioka T, Usami T, Matsukawa N, Neurol and Clinical Neurosci., 6, (2) 59 - 61,   2018年, 査読有り
  • Miller Fisher syndrome mimicking Tolosa-Hunt syndrome., Oomura M, Uchida Y, Sakurai K, Toyoda T, Okita K, Matsukawa N, Intern Med., 57, (18) 2735 - 2738,   2018年, 査読有り
  • Early treatment for IgG4-related disease may prevent cognitive impairment caused by cerebral vasculitis: A case report and review of the literature., Usami T, Kawashima S, Ueki Y, Toyoda T, Okita K, Matsukawa N, eNeurological Sci., 10, 45 - 47,   2018年, 査読有り
  • Assessment of the Correlation Between Carotid Artery Plaque Density Determined by Histogram Analysis and Positive Remodeling on Computerized Tomography Angiography, Ogawa M, Ozawa Y, Muto M, Katano H, Yamada K, Miura T, Matsukawa N, Shibamoto Y, Iranian J Radiology, 15, (1) ,   2018年, 査読有り
  • Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis: a case report., Uchida Y, Kato D, Yamashita Y, Ozaki Y, Matsukawa N, Neuropsychiatr Dis Treat., 14, 339 - 342,   2018年, 査読有り
  • Is preservation of cholinergic activation a mechanism underlying cognitive reserve?, Matsukawa N, J Alzheimers Dis Parkinsonism, 8, 425 - 425,   2018年, 査読有り
  • Establishing a New Screening System for Mild Cognitive Impairment and Alzheimer's Disease with Mental Rotation Tasks that Evaluate Visuospatial Function., Suzuki A, Shinozaki J, Yazawa S, Ueki Y, Matsukawa N, Shimohama S, Nagamine T, J Alzheimers Dis., 61, (4) 1653 - 1665,   2018年, 査読有り
  • Stiripentol for the treatment of super-refractory status epilepticus with cross-sensitivity., Uchida Y, Terada K, Madokoro Y, Fujioka T, Mizuno M, Toyoda T, Kato D, Matsukawa N, Acta Neurol Scand, 137, (4) 432 - 437,   2018年, 査読有り
  • Utility of T1-and T2-Weighted High-Resolution Vessel Wall Imaging for the Diagnosis and Follow Up of Isolated Posterior Inferior Cerebellar Artery Dissection with Ischemic Stroke: Report of 4 Cases and Review of the Literature, Yuta Madokoro, Keita Sakurai, Daisuke Kato, Yuko Kondo, Masahiro Oomura, Noriyuki Matsukawa, JOURNAL OF STROKE & CEREBROVASCULAR DISEASES, 26, (11) 2645 - 2651,   2017年11月, 査読有り, Background: An accurate diagnosis of isolated posterior inferior cerebellar artery dissection (iPICA-D) is difficult due to the limitation of spatial resolution on conventional magnetic resonance imaging (MRI) techniques to detect subtle vessel wall abnormalities. The recent development of MRI techniques, including high-resolution vessel wall imaging (HRVWI), has resulted in the improved diagnostic accuracy and efficiency of iPICA-D. In fact, T1-weighted HRVWI, which can reveal intramural hematomas in the posterior inferior cerebellar artery (PICA), is useful for the diagnosis of iPICA-D. However, the utility of T2-weighted HRVWI has not been previously reported. The aim of this study was to investigate the diagnostic utility of T1- and T2-weighted HRVWI for the diagnosis of iPICA-D. Methods: We retrospectively evaluated MRI findings including intramural hematomas, dilations, and chronological changes in 4 patients with iPICA-D admitted to our hospital and related facility from January 2015 to August 2016. In addition to T1-weighted HRVWI, T2-weighted HRVWI was performed on isovoxel three-dimensional (3D) fast spin-echo or 3D sampling perfection with application-optimized contrast using different flip-angle evolution. We also reviewed cases of nonhemorrhagic iPICA-D with ischemic onset in which the MRI findings were described. Results: In all 4 patients, in addition to the intramural hematomas on T1-weighted HRVWI, T2-weighted HRVWI clearly showed the fusiform dilation of the external diameter of the PICA. T2-weighted HRVWI was more useful than other techniques, including T1-weighted HRVWI, for the evaluation of arterial shape changes. Conclusions: Like T1-weighted HRVWI, T2-weighted HRVWI is useful for the diagnosis and assessment of chronological changes in vessel wall abnormalities during the follow-up period.
  • Dinosaur Tail Sign: A Useful Spinal MRI Finding Indicative of Cerebrospinal Fluid Leakage, Keita Sakurai, Masafumi Kanoto, Motoo Nakagawa, Masashi Shimohira, Aya M. Tokumaru, Masashi Kameyama, Keigo Shimoji, Satoru Morimoto, Noriyuki Matsukawa, Minoru Nishio, Yuta Shibamoto, HEADACHE, 57, (6) 917 - 925,   2017年06月, 査読有り, ObjectiveTo evaluate the imaging characteristics and diagnostic utility of the Dinosaur tail sign in the diagnosis of cerebrospinal fluid (CSF) leakage. BackgroundThe authors propose the Dinosaur tail sign, defined as a combination of the dorsal epidural hyperintensities, fat tissue, spinal cord, and cauda equine on lumbosacral sagittal fat-suppressed T2-weighted image (FST2WI), as a sensitive indicator for diagnosing CSF leakage. MethodsImaging characteristics of the Dinosaur tail sign was evaluated in seven spontaneous intracranial hypotension (SIH) and 23 iatrogenic CSF leakage (ICSFL) patients. Additionally, the diagnostic index was compared between the Dinosaur tail sign and other previously reported useful magnetic resonance imaging (MRI) and magnetic resonance myelography (MRM) findings. ResultsIn contrast to other imaging findings including the epidural expansion, floating dural sac sign, and distension of the spinal epidural veins on MRI, and paraspinal fluid collections (PFC) on MRM, the Dinosaur tail sign was found equally in both SIH and ICSFL patients (6 SIH and 19 ICSFL; 83% of all patients with CSF leakage). The Dinosaur tail sign showed sufficient diagnostic utility (sensitivity 83%, specificity 94%, accuracy 89%) that was comparable to that of PFC. ConclusionThe Dinosaur tail sign is a useful imaging finding suggestive of CSF leakage. Evaluation of subtle interspinous arched hyperintensities on spinal MRI is mandatory for the diagnosis of SIH and ICSFL.
  • Paranodal dissection in chronic inflammatory demyelinating polyneuropathy with anti-neurofascin-155 and anti-contactin-1 antibodies, Haruki Koike, Masato Kadoya, Ken-ichi Kaida, Shohei Ikeda, Yuichi Kawagashira, Masahiro Iijima, Daisuke Kato, Hidenori Ogata, Ryo Yamasaki, Noriyuki Matsukawa, Jun-ichi Kira, Masahisa Katsuno, Gen Sobue, JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 88, (6) 465 - 473,   2017年06月, 査読有り, Objective To investigate the morphological features of chronic inflammatory demyelinating polyneuropathy (CIDP) with autoantibodies directed against paranodal junctional molecules, particularly focusing on the fine structures of the paranodes. Methods We assessed sural nerve biopsy specimens obtained from 9 patients with CIDP with anti-neurofascin-155 antibodies and 1 patient with anti-contactin-1 antibodies. 13 patients with CIDP without these antibodies were also examined to compare pathological findings. Results Characteristic light and electron microscopy findings in transverse sections from patients with anti-neurofascin-155 and anti-contactin-1 antibodies indicated a slight reduction in myelinated fibre density, with scattered myelin ovoids, and the absence of macrophage-mediated demyelination or onion bulbs. Teased-fibre preparations revealed that segmental demyelination tended to be found in patients with relatively higher frequencies of axonal degeneration and was tandemly found at consecutive nodes of Ranvier in a single fibre. Assessment of longitudinal sections by electron microscopy revealed that detachment of terminal myelin loops from the axolemma was frequently found at the paranode in patients with anti-neurofascin-155 and anti-contactin-1 antibody-positive CIDP compared with patients with antibody-negative CIDP. Patients with anti-neurofascin-155 antibodies showed a positive correlation between the frequencies of axo-glial detachment at the paranode and axonal degeneration, as assessed by teased-fibre preparations (p<0.05). Conclusions Paranodal dissection without classical macrophage-mediated demyelination is the characteristic feature of patients with CIDP with autoantibodies to paranodal axo-glial junctional molecules.
  • β1 integrin signaling promotes neuronal migration along vascular scaffolds in the post-stroke brain., Fujioka T, Kaneko N, Ajioka I, Nakaguchi K, Omata T, Ohba H, Fässler R, García-Verdugo JM, Sekiguchi K, Matsukawa N, Sawamoto K, EBioMedicine., 16, 195 - 203,   2017年02月, 査読有り
  • Anti-N-methyl-d-aspartate receptor limbic encephalitis associated with mature cystic teratoma of the fallopian tube, Yukio Hattori, Yoriko Yamashita, Masayuki Mizuno, Kinue Katano, Mayumi Sugiura-Ogasawara, Noriyuki Matsukawa, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 43, (2) 412 - 415,   2017年02月, 査読有り, Anti-N-methyl-d-aspartate receptor (NMDAR) limbic encephalitis is the most common form of paraneoplastic encephalitis that is associated with teratomas. Because tumor removal leads to better clinical outcomes, it is essential to reveal the location of the teratomas. This is the first reported case of anti-NMDAR encephalitis associated with teratoma of the fallopian tube. Salpingo-oophorectomy improved neurological symptoms and immunohistochemical examinations indicated the expression of NMDAR on neuroglial cells within the fallopian tube teratoma. Teratomas of the fallopian tube cause anti-NMDAR encephalitis; the imaging analysis and exploratory laparoscopies of the fallopian tube as well as of the ovary should be considered. Surgical removal of both fallopian tubes and ovaries with a normal appearance should be considered for patients in whom immunotherapy is not effective.
  • Fatal remote cerebral hemorrhage at a site of microbleed immediately after intravenous thrombolysis., Oomura M, Fujioka T, Uchida Y, Kato D, Nishikawa Y, Matsukawa N, Neurol and Clinical Neurosci., 5, (4) 118 - 120,   2017年, 査読有り
  • Passively acquired thyroid autoantibodies from intravenous immunoglobulin in autoimmune encephalitis: Two case reports., Uchida Y, Kato D, Adachi K, Toyoda T, Matsukawa N, J Neurol Sci., 383, 116 - 117,   2017年, 査読有り
  • Hippocampal Cholinergic Neurostimulating Peptide as a Possible Modulating Factor against Glutamatergic Neuronal Disability by Amyloid Oligomers., Sato T, Ohi Y, Kato D, Mizuno M, Takase H, Kanamori T, Borlongan CV, Haji A, Matsukawa N, Cell Transplant., 26, (5) 1543 - 1550,   2017年, 査読有り
  • Madokoro Y, Sakurai K, Kato D, Kondo Y, Oomura M, Matsukawa N., Madokoro Y, Sakurai K, Kato D, Kondo Y, Oomura M, Matsukawa N, J Stroke Cerebrovasc Dis, 26, (11) 2645 - 2651,   2017年, 査読有り
  • Beyond the midbrain atrophy: wide spectrum of structural MRI finding in cases of pathologically proven progressive supranuclear palsy., Sakurai K, Tokumaru AM, Shimoji K, Murayama S, Kanemaru K, Morimoto S, Aiba I, Nakagawa M, Ozawa Y, Shimohira M, Matsukawa N, Hashizume Y, Shibamoto Y, Neuroradiology, 16, 431 - 443,   2017年, 査読有り
  • Hyperdense Vessel Signs Showing Migration of a Thrombus, Yuya Ohno, Masahiro Oomura, Keita Sakurai, Noriyuki Matsukawa, INTERNAL MEDICINE, 56, (4) 465 - 466,   2017年, 査読有り
  • Combination of ketogenic diet and stiripentol for super-refractory status epilepticus: A case report., Uchida Y, Kato D, Toyoda T, Oomura M, Ueki Y, Ohkita K, Matsukawa N, J Neurol Sci., 373, (35) ,   2017年, 査読有り
  • Retropharyngeal calcific tendinitis presenting with neck pain and severe dysphagia: A case report., Madokoro Y, Mizuno M, Kato D, Toyoda T, Okita K, Matsukawa N, Neurol and Clinical Neurosci., 5, (3) 91 - 92,   2017年, 査読有り
  • Volume of Interest Analysis of Spatially Normalized PRESTO Imaging to Differentiate between Parkinson Disease and Atypical Parkinsonian Syndrome, Keita Sakurai, Etsuko Imabayashi, Aya M. Tokumaru, Kimiteru Ito, Keigo Shimoji, Motoo Nakagawa, Yoshiyuki Ozawa, Masashi Shimohira, Masaki Ogawa, Satoru Morimoto, Ikuko Aiba, Noriyuki Matsukawa, Yuta Shibamoto, MAGNETIC RESONANCE IN MEDICAL SCIENCES, 16, (1) 16 - 22,   2017年, 査読有り, Purpose: Various magnetic resonance imaging (MRI) techniques including T2*-weighted imaging, susceptibility -weighted imaging, and MR relaxometry had been performed to evaluate different patterns of brain iron depositions in Parkinsonian syndrome. The aim of the present study was to evaluate the diagnostic value of a volume of interest (VOI) analysis on the principles of echo shifting with a train of observations (PRESTO) imaging using the statistical parametric mapping (SPM) 8 and the WFU PickAtlas program for the diagnosis of Parkinsonian syndrome. Methods: Fifty subjects, including 13 with the Parkinsonian variant of multiple system atrophy (MSA-P), 12 with progressive supranuclear palsy (PSP), 12 with Parkinson's disease (PD) and 13 controls were evaluated in this study. After the spatial normalization of PRESTO images on SPM8, the WFU PickAtlas program was performed to create target VOIs in the putamen, red nucleus, substantia nigra, subthalamic nucleus, and dentate nucleus. The signal intensity ratio (SIR) was calculated by normalizing the signal of each VOI to that of the cerebrospinal fluid space. These SIRs were used as determinants in receiver operating characteristic (ROC) analyses. Results: SIR of the putamen was significantly lower in MSA-P than in PSP (P = 0.0051) and controls (P = 0.0004). In contrast, SIR of the red nucleus was significantly lower in PSP than in MSA-P (P = 0.0003), PD (P = 0.0029), and controls (P = 0.0011). In ROC analyses, SIR of the putamen exhibited the highest areas under the curves (AUCs) of 0.83 (vs. PSP) and 0.91 (vs. controls) in the diagnosis of MSA-P. On the other hand, SIR of the red nucleus exhibited the highest AUCs of 0.87 (vs. MSA-P), 0.90 (vs. PD), and 0.89 (vs. controls) in the diagnosis of PSP. Conclusions: The VOI analysis based on spatially normalized PRESTO images may be useful for depicting hypointensity, indicative of abnormal iron depositions, of the putamen and red nucleus in the diagnosis of MSA-P and PSP.
  • Guillain-Barré syndrome after allogeneic bone marrow transplantation., Yoshida T, Ueki Y, Suzuki T, Kawagashira Y, Koike H, Kusumoto S, Iida S, Oguri T, Omura M, Sobue G, Matsukawa N, eNeurological Sci., 4, 52 - 55,   2016年, 査読有り
  • Self-management behaviors and psychological and social factors influencing QOL in patients with parkinson disease, Yukako Ando, Yoshino Ueki, Takemori Yamawaki, Itsuko Ozaki, Akemi Abe, Akira Inukai, Ikuko Aiba, Yufuko Saito, Katsuhiko Kawaminami, Noriyuki Matsukawa, Toshio Kobayashi, QUALITY OF LIFE RESEARCH, 24, 153 - 153,   2015年10月, 査読有り
  • Enhancement of long-term potentiation via muscarinic modulation in the hippocampus of HCNP precursor transgenic mice, Yoshiaki Ohi, Daisuke Kato, Masayuki Mizuno, Toyohiro Sato, Yoshino Ueki, Cesario V. Borlongan, Kosei Ojika, Akira Haji, Noriyuki Matsukawa, NEUROSCIENCE LETTERS, 597, 1 - 6,   2015年06月, 査読有り, Hippocampal cholinergic neurostimulating peptide (HCNP) regulates acetylcholine synthesis in the septal hippocampus through the quantitative increase of choline acetyltransferase levels in the septal nucleus both in vitro and in vivo. Additionally, HCNP-precursor protein transgenic (HCNP-pp Tg) mice display depressive behavior. To examine the physiological function of HCNP and/or HCNP-pp on hippocampal neural activity, we investigated whether overexpression of HCNP-pp strengthened the efficiency of neural activity in the hippocampus. Long-term potentiation (LTP) of excitatory synaptic transmission was induced by a tetanic stimulation of the Schaffer collateral-commissural fibers (SCs) in mouse hippocampal slices. LTP in HCNP-pp Tg mice was significantly enhanced when compared with wild-type littermate (WT) mice. This facilitation of LTP in HCNP-pp Tg mice was blocked by atropine or pirenzepine, but not by mecamylamine. In contrast, LTP in WT mice was not affected by atropine, but enhanced by carbachol. However, neither difference in the input-output relationship of field excitatory postsynaptic potentials nor in the facilitation ratio in paired-pulse stimulation of the SCs was observed between HCNP-pp Tg and WT mice, indicating that presynaptic glutamate release in HCNP-pp Tg mice is similar to that of WT mice. These results suggest that muscarinic (M1) modulation of glutamatergic postsynaptic function may be involved in strengthening LTP in HCNP-pp Tg mice. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
  • Two brothers homozygous for the TTR V30M both presenting with a phenotype dominated by central nervous complications., Uchida Y, Takada K, Tsugu Y, Ueda M, Yamashita T, Ando Y, Kobayashi S, Koike H, Watanabe T, Matsumoto T, Toyoda T, Yamada G, Matsukawa N, Amyloid., 22, (4) 261 - 262,   2015年, 査読有り
  • The feasibility of white matter volume reduction analysis using SPM8 plus DARTEL for the diagnosis of patients with clinically diagnosed corticobasal syndrome and Richardson's syndrome., Sakurai K, Imabayashi E, Tokumaru AM, Hasebe S, Murayama S, Morimoto S, Kanemaru K, Takao M, Shibamoto Y, Matsukawa N, Neuroimage Clin., 7, 605 - 610,   2015年, 査読有り
  • Internal carotid artery blister-like aneurysm caused by Aspergillus - case report., Ogawa M, Sakurai K, Kawaguchi T, Naiki-Ito A, Nakagawa M, Okita K, Matsukawa N, Shibamoto Y, Pol J Radiol., 80, 159 - 163,   2015年, 査読有り
  • Blood-based diagnosis of Alzheimer's disease using fingerprinting metabolomics based on hydrophilic interaction liquid chromatography with mass spectrometry and multivariate statistical analysis., Inoue K, Tsuchiya H, Takayama T, Akatsu H, Hashizume Y, Yamamoto T, Matsukawa N, Toyo'oka T, J Chromatogr B Analyt Technol Biomed Life Sci., 974, 24 - 34,   2015年, 査読有り
  • The utility of cerebral perfusion SPECT analysis using SPM8, eZIS and vbSEE for the diagnosis of multiple system atrophy-parkinsonism., Sakurai K, Imabayashi E, Ito K, Tokumaru AM, Ozawa Y, Muto M, Nakagawa M, Okita K, Matsukawa N, Shibamoto Y, Ann Nucl Med, 29, (2) 206 - 213,   2015年, 査読有り
  • Comparison of Effects of Valsartan and Amlodipine on Cognitive Functions and Auditory P300 Event-Related Potentials in Elderly Hypertensive Patients, Eiichi Katada, Norihiko Uematsu, Yuko Takuma, Noriyuki Matsukawa, CLINICAL NEUROPHARMACOLOGY, 37, (5) 129 - 132,   2014年09月, 査読有り, Objective: We compared the antihypertensive effect of valsartan (VAL) and amlodipine (AML) treatments in elderly hypertensive patients by examining the long-term changes in cognitive function and auditory P300 event-related potentials. Methods: We enrolled 20 outpatients, including 12 men and 8 women in the age group of 56 to 81 years who had mild to moderate essential hypertension. The subjects were randomly allocated to receive either 80 mg VAL once a day (10 patients) or 5 mg AML once a day (10 patients). Neuropsychological assessment and auditory P300 event-related potentials were obtained before initiation of VAL or AML treatment and after 6 months of the treatment with VAL or AML. Neuropsychological assessment was evaluated by conducting the Mini-Mental State Examination, the verbal fluency, word-list memory, word-list recall test, word-list recognition, and Trails B tests. Results: Both the groups showed significantly reduced-blood pressure after 6 months of treatment, and the intergroup difference was not significant. The mean baseline Mini-Mental State Examination scores of the VAL and AML groups were not significantly different. Amlodipine treatment did not significantly affect any test score, but VAL treatment significantly increased the word-list memory and word-list recall test scores. Valsartan, and not AML, significantly reduced the mean P300 latency after 6 months. Conclusions: These results suggest that VAL exerts a positive effect on cognitive functions, independent of its antihypertensive effect.
  • Postsurgical propriospinal myoclonus emerging at wake to sleep transition, Takuya Oguri, Kazuki Hisatomi, Shoji Kawashima, Yoshino Ueki, Naoko Tachibana, Noriyuki Matsukawa, SLEEP MEDICINE, 15, (1) 152 - 154,   2014年01月, 査読有り
  • Simultaneous determination of post-translational recemization and isomerization of N-terminal amyloid-β in Alzheimer brain tissues by covalent chiral derivatized ultraperformance liquid chromatography tandem mass spectrometry, Inoue K, Hosaka D, Mochizuki N, Akatsu H, Tsutsumiuchi K, Hashizume Y, Matsukawa N, Tamamoto T, Toyo'oka T, Anal Chem, 86, (1) 797 - 804,   2014年01月, 査読有り
  • Imaging epectrum of sporadic cerebral amyloid angiopathy: multifaceted features of a single pathological condition, Sakurai K, Tokumaru AM, Nakatsuka T, Maruyama S, Hasebe S, Imabayashi E, Kanemaru K, Takao M, Hatsuta H, Ishii K, Saito Y, Shibamoto Y, MAtsukawa N, Chikui E, Terada H, Insights Imaging,   2014年, 査読有り
  • LACTOBACILLUS IN JELLY ENHANCES THE EFFECT OF INFLUENZA VACCINATION IN ELDERLY INDIVIDUALS, Hiroyasu Akatsu, Kazuyuki Arakawa, Takayuki Yamamoto, Takayoshi Kanematsu, Noriyuki Matsukawa, Hirotaka Ohara, Mitsuo Maruyama, JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 61, (10) 1828 - 1830,   2013年10月, 査読有り
  • LACTOBACILLUS IN JELLY ENHANCES THE EFFECT OF INFLUENZA VACCINATION IN ELDERLY INDIVIDUALS, Hiroyasu Akatsu, Kazuyuki Arakawa, Takayuki Yamamoto, Takayoshi Kanematsu, Noriyuki Matsukawa, Hirotaka Ohara, Mitsuo Maruyama, JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 61, (10) 1828 - 1830,   2013年10月, 査読有り
  • Lumbar puncture-related cerebrospinal fluid leakage on magnetic resonance myelography: is it a clinically significant finding?, Keita Sakurai, Noriyuki Matsukawa, Kenji Okita, Minoru Nishio, Masashi Shimohira, Yoshiyuki Ozawa, Susumu Kobayashi, Takemori Yamawaki, Yuta Shibamoto, BMC ANESTHESIOLOGY, 13, (1) ,   2013年10月, 査読有り, Background: Post-dural puncture headache (PDPH) due to excessive cerebrospinal fluid (CSF) leakage is a well-known complication of lumbar puncture. Although various factors, especially the type of spinal needle, have been demonstrated to be associated with PDPH, the clinical implications of CSF leakage detected on magnetic resonance myelography (MRM) images remain unclear. The objective of this case-control study was to evaluate the association between radiologically visualized CSF leakage and PDPH. Methods: Clinical data including patients' age and gender, types of spinal needle, duration of bed rest, interval between lumbar puncture procedures and MRM studies, and incidence of PDPH were compared between patients who were radiologically-positive and -negative for CSF leakage. Results: Of the 22 patients with definite CSF leakage on MRM images, most were asymptomatic (86%, 19/22). The remaining three patients, who were suffering from PDPH, only complained of headaches and were treated conservatively. In a review of patients' clinical data, there were no significant differences in any parameter including the incidence of PDPH between the 22 patients who were radiologically-positive for CSF leakage and the 31 radiologically-negative patients. Conclusion: The significance of radiologically visualized CSF leakage should not be overestimated, as most such incidents are not associated with PDPH and do not require any treatment.
  • Metabolic profiling of Alzheimer's disease brains, Koichi Inoue, Haruhito Tsutsui, Hiroyasu Akatsu, Yoshio Hashizume, Noriyuki Matsukawa, Takayuki Yamamoto, Toshimasa Toyo'oka, SCIENTIFIC REPORTS, 3,   2013年08月, 査読有り, Alzheimer's disease (AD) is an irreversible, progressive brain disease and can be definitively diagnosed after death through an examination of senile plaques and neurofibrillary tangles in several brain regions. It is to be expected that changes in the concentration and/or localization of low-molecular-weight molecules are linked to the pathological changes that occur in AD, and determining their identity would provide valuable information regarding AD processes. Here, we propose definitive brain metabolic profiling using ultra-performance liquid chromatography coupled with electrospray time-of-flight mass spectrometry analysis. The acquired data were subjected to principal components analysis to differentiate the frontal and parietal lobes of the AD/Control groups. Significant differences in the levels of spermine and spermidine were identified using S-plot, mass spectra, databases and standards. Based on the investigation of the polyamine metabolite pathway, these data establish that the downstream metabolites of ornithine are increased, potentially implicating ornithine decarboxylase activity in AD pathology.
  • Evaluation of luminal and vessel wall abnormalities in subacute and other stages of intracranial vertebrobasilar artery dissections using the volume isotropic turbo-spin-echo acquisition (VISTA) sequence: A preliminary study, Keita Sakurai, Toshiyasu Miura, Takafumi Sagisaka, Manabu Hattori, Noriyuki Matsukawa, Mitsuhito Mase, Harumasa Kasai, Nobuyuki Arai, Tatsuya Kawai, Masashi Shimohira, Takemori Yamawaki, Yuta Shibamoto, JOURNAL OF NEURORADIOLOGY, 40, (1) 19 - 28,   2013年03月, 査読有り, Objective: To evaluate the utility of 3D variable refocusing flip-angle volume isotropic turbo-spin-echo acquisition (VISTA) imaging, using a 1.5-T MRI unit, which can minimize flow artifacts, due to its sequence-endogenous flow-void capability, in the diagnosis of intracranial verte-brobasilar artery dissection (VAD). Material and methods: The presence of intimal flaps, intramural hematomas, vessel dilatations and abnormal vessel enhancements were evaluated on T1-weighted VISTA images from 18 VAD patients with 20 dissected arteries (15 subacute and five at other stages). Additional gadolinium-enhanced T1 VISTA images were available for 13 patients. The frequency of flow artifacts on T1VISTA imaging in 70 non-dissected arteries in VAD patients and 12 control subjects was also evaluated. Furthermore, in 13 and eight patients, contrast-enhanced three-dimensional (CE3D) imaging with spoiled gradient-recalled (SPGR) acquisition in steady state and electrocardio-graphically gated black-blood (BB) T1-weighted imaging (T1WI) were evaluated to compare visualization of false lumens. Results: Intimal flaps, intramural hematonnas and dilatations were identified on T1 VISTA images in 65% (13/20), 55% (11/20) and 90% (18/20) of VADs, respectively. Abnormal vessel enhancement was recognized in 100% (15/15) of VADs on contrast-enhanced T1VISTA images. Only four normal arteries showed small, thin, linear artifacts. Compared with CE3D-SPGR imaging,T1VISTA imaging depicted false lumens more conspicuously in seven VADs (P=0.02). T1VISTA. also revealed intimal flaps and hematomas as did BB T1WI. Conclusion: T1VISTA imaging may be useful for diagnosing VAD at subacute stages, as it can reveal vessel wall and lumen abnormalities with a minimum of flow artifacts. (C) 2012 Elsevier Masson SAS. All rights reserved.
  • Phosphorylation of collapsin response mediator protein-2 regulates its localization and association with hippocampal cholinergic neurostimulating peptide precursor in the hippocampus, Masayuki Mizuno, Daisuke Kato, Tetsuko Kanamori, Takanari Toyoda, Tatsuo Suzuki, Kosei Ojika, Noriyuki Matsukawa, NEUROSCIENCE LETTERS, 535, 122 - 127,   2013年02月, 査読有り, Hippocampal cholinergic neurostimulating peptide (HCNP) induces the synthesis of acetylcholine in the medial septal nucleus in vitro and in vivo. The precursor, HCNP-pp, is a multifunctional protein participating in important signaling pathways, such as MAPK/ERK kinase (MEK) and G-protein-coupled receptor kinase 2 (GRK2). We recently demonstrated that HCNP-pp colocalizes with collapsin response mediator protein-2 (CRMP-2) at presynaptic terminals in the hippocampus, suggesting that HCNP-pp may play an important role in presynaptic function in association with CRMP-2. To clarify the involvement of phosphorylation in regulating the interaction between HCNP-pp and CRMP-2, we investigated the colocalization of HCNP-pp with unphosphorylated- and/or phosphorylated-CRMP-2 (pCRMP-2) at presynaptic terminals. We further determined if the phosphorylation of CRMP-2 affects the binding between those proteins. Here, we demonstrate that HCNP-pp predominantly colocalizes and associates with unphosphorylated and/or pSer-522-CRMP-2 at presynaptic terminals in the hippocampus. Interestingly, HCNP-pp does not associate with pThr-509/514-CRMP-2, which is primarily localized at postsynaptic terminals. These findings suggest that HCNP-pp, in association with unphosphorylated and/or pSer522-CRMP-2, plays an important role in presynaptic function in the mature hippocampus. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
  • Differences in dopaminergic modulation to motor cortical plasticity between Parkinson’s disease and multiple system atrophy., Kawashima S, Ueki Y, Mima T, Fukuyama H, Ojika K, Matsukawa N, PLoS One, 8, (5) ,   2013年, 査読有り
  • Overlaping connections within the motor cortico-basal ganglia circuit; fMRI-tractography analysis, Oguri T, Sawamoto N, Tabu H, Urayama S, Matsuhashi M, Matsukawa N, Ojika K, Fukuyama H, NeuroImage, 78, 358 - 62,   2013年, 査読有り
  • Successful treatment of granulomatous amoebic encephalopathy with combination antimicrobial therapy, Kato H, Mitake S, Yuasa H, Hayashi S, Hara T, Matsukawa N, Intern Med, 52, (17) 1977 - 81,   2013年, 査読有り
  • Neurological deficits in a patient with selenium deficiency due to long-term total parenteral nutrition, Takuya Oguri, Manabu Hattori, Takemori Yamawaki, Satoshi Tanida, Makoto Sasaki, Takashi Joh, Noriyuki Matsukawa, Kosei Ojika, JOURNAL OF NEUROLOGY, 259, (8) 1734 - 1735,   2012年08月, 査読有り
  • Temporary deterioration of executive function after subthalamic deep brain stimulation in parkinson’s disease., Yamanaka T, Ishii F, Umemura A, Miyata M, Horiba M, Oka Y, Yamada K, Toyoda T, Okita K, Clin Neurol Neurosurg, 114, (4) 347 - 351,   2012年05月, 査読有り
  • Co-localization of hippocampal cholinergic neurostimulating peptide precursor with collapsin response mediator protein-2 at presynaptic terminals in hippocampus, Daisuke Kato, Shigehisa Mitake, Masayuki Mizuno, Tetsuko Kanamori, Tatsuo Suzuki, Kosei Ojika, Noriyuki Matsukawa, NEUROSCIENCE LETTERS, 517, (2) 92 - 97,   2012年05月, 査読有り, Hippocampal cholinergic neurostimulating peptide (HCNP) induces the synthesis of acetylcholine in medial septal nucleus in vitro and in vivo. HCNP precursor protein (HCNP-pp) is a multifunctional protein that participates in a number of signaling pathways, including MAPK/extracellular signal and G-protein-coupled receptor kinase 2. We recently demonstrated that the amount of collapsin response mediator protein-2 (CRMP-2) is increased in hippocampus of HCNP-pp transgenic mice. To clarify the interaction between HCNP/HCNP-pp and CRMP-2 and its role in synaptic function, we investigated whether HCNP-pp is localized to the synapse and if it affects protein expression. Here, we demonstrate that HCNP-pp co-localizes with CRMP-2 at presynaptic terminals. Furthermore, HCNP-pp overexpression increases synaptophysin levels. These findings suggest that HCNP-pp, in association with CRMP-2, plays an important role in presynaptic function in the hippocampus. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
  • Clinico-radiological features of subarachnoid hyperintensity on diffusion-weighted images in patients with meningitis, T. Kawaguchi, K. Sakurai, M. Hara, M. Muto, M. Nakagawa, J. Tohyama, T. Oguri, S. Mitake, M. Maeda, N. Matsukawa, K. Ojika, Y. Shibamoto, CLINICAL RADIOLOGY, 67, (4) 306 - 312,   2012年04月, 査読有り, AIM: To investigate the clinical and radiological features of meningitis with subarachnoid diffusion-weighted imaging (DWI) hyperintensity. MATERIALS AND METHODS: The clinical features, laboratory data, and radiological findings, including the number and distribution of subarachnoid DWI hyperintense lesions and other radiological abnormalities, of 18 patients seen at five institutions were evaluated. RESULTS: The patients consisted of eight males and 10 females, whose ages ranged from 4 months to 82 years (median 65 years). Causative organisms were bacteria in 15 patients, including Haemophilus influenzae, Streptococcus pneumoniae, Streptococcus agalactiae, Staphylococcus aureus, Klebsiella pneumoniae, and Listeria monocytogenes. The remaining three were fungal meningitis caused by Cryptococcus neoformans. Subarachnoid DWI hyperintense lesions were multiple in 16 of the 18 cases (89%) and predominantly distributed around the frontal lobe in 16 of the 18 cases (89%). In addition to subarachnoid abnormality, subdural empyema, cerebral infarction, and intraventricular empyema were found in 50, 39, and 39%, respectively. Compared with paediatric patients, adult patients with bacterial meningitis tended to have poor prognoses (7/10 versus 1/5; p = 0.1). CONCLUSION: Both bacterial and fungal meningitis could cause subarachnoid hyperintensity on DWI, predominantly around the frontal lobe. This finding is often associated with poor prognosis in adult bacterial meningitis. (C) 2011 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
  • Changes in Striatal Dopamine Release Associated with Human Motor-Skill Acquisition, Shoji Kawashima, Yoshino Ueki, Takashi Kato, Noriyuki Matsukawa, Tatsuya Mima, Mark Hallett, Kengo Ito, Kosei Ojika, PLOS ONE, 7, (2) ,   2012年02月, 査読有り, The acquisition of new motor skills is essential throughout daily life and involves the processes of learning new motor sequence and encoding elementary aspects of new movement. Although previous animal studies have suggested a functional importance for striatal dopamine release in the learning of new motor sequence, its role in encoding elementary aspects of new movement has not yet been investigated. To elucidate this, we investigated changes in striatal dopamine levels during initial skill-training (Day 1) compared with acquired conditions (Day 2) using C-11-raclopride positron-emission tomography. Ten volunteers learned to perform brisk contractions using their non-dominant left thumbs with the aid of visual feedback. On Day 1, the mean acceleration of each session was improved through repeated training sessions until performance neared asymptotic levels, while improved motor performance was retained from the beginning on Day 2. The C-11-raclopride binding potential (BP) in the right putamen was reduced during initial skill-training compared with under acquired conditions. Moreover, voxel-wise analysis revealed that C-11-raclopride BP was particularly reduced in the right antero-dorsal to the lateral part of the putamen. Based on findings from previous fMRI studies that show a gradual shift of activation within the striatum during the initial processing of motor learning, striatal dopamine may play a role in the dynamic cortico-striatal activation during encoding of new motor memory in skill acquisition.
  • Suppression of Astrocyte Lineage in Adult Hippocampal Progenitor Cells Expressing Hippocampal Cholinergic Neurostimulating Peptide Precursor in an In Vivo Ischemic Model, Takanari Toyoda, Noriyuki Matsukawa, Takafumi Sagisaka, Norihiko Uematsu, Tetsuko Kanamori, Daisuke Kato, Masayuki Mizuno, Hiroaki Wake, Hideki Hida, Cesario V. Borlongan, Kosei Ojika, CELL TRANSPLANTATION, 21, (10) 2159 - 2169,   2012年, 査読有り, Hippocampal cholinergic neurostimulating peptide (HCNP) is known to promote differentiation of septo-hippocampal cholinergic neurons. The HCNP precursor protein (HCNP-pp) may play several roles, for example, as an ATP-binding protein, a Raf kinase inhibitor protein, and a phosphatidylethanolamine-binding protein, as well as a precursor for HCNP. This study therefore aimed to elucidate the involvement of HCNP-pp in specific neural lineages after stroke using a hypoxic-ischemic (HI) rat model of brain ischemia. The specific neural lineages in the hippocampus were investigated 14 days after ischemia. Some bromodeoxyuridine (BrdU)(+) neural progenitor cells in the hippocampus of hypoxic, HI, or sham-operated rats expressed HCNP-pp. Almost half of the BrdU(+)/HCNP-pp(+) cells also expressed the oligodendrocyte lineage marker 2',3'-cyclic nucleotide 3'-phosphodiesterase, whereas only a few BrdU(+)/HCNP-pp(+) cells in the hippocampus in HI brains expressed the neuronal lineage marker, doublecortin (DCX). Interestingly, no BrdU(+)/HCNP-pp(+) progenitor cells in hypoxic, HI, or sham-operated brains expressed the astrocyte lineage marker, glial fibrillary acidic protein. Together with previous in vitro data, the results of this study suggest that the expression level of HCNP-pp regulates the differentiation of neural progenitor cells into specific neural lineages in the HI hippocampus, indicating that neural stem cell fate can be controlled via the HCNP-pp mediating pathway.
  • Suppression of Astrocyte Lineage in Adult Hippocampal Progenitor Cells Expressing Hippocampal Cholinergic Neurostimulating Peptide Precursor in an In Vivo Ischemic Model, Takanari Toyoda, Noriyuki Matsukawa, Takafumi Sagisaka, Norihiko Uematsu, Tetsuko Kanamori, Daisuke Kato, Masayuki Mizuno, Hiroaki Wake, Hideki Hida, Cesario V. Borlongan, Kosei Ojika, CELL TRANSPLANTATION, 21, (10) 2159 - 2169,   2012年, 査読有り, Hippocampal cholinergic neurostimulating peptide (HCNP) is known to promote differentiation of septo-hippocampal cholinergic neurons. The HCNP precursor protein (HCNP-pp) may play several roles, for example, as an ATP-binding protein, a Raf kinase inhibitor protein, and a phosphatidylethanolamine-binding protein, as well as a precursor for HCNP. This study therefore aimed to elucidate the involvement of HCNP-pp in specific neural lineages after stroke using a hypoxic-ischemic (HI) rat model of brain ischemia. The specific neural lineages in the hippocampus were investigated 14 days after ischemia. Some bromodeoxyuridine (BrdU)(+) neural progenitor cells in the hippocampus of hypoxic, HI, or sham-operated rats expressed HCNP-pp. Almost half of the BrdU(+)/HCNP-pp(+) cells also expressed the oligodendrocyte lineage marker 2',3'-cyclic nucleotide 3'-phosphodiesterase, whereas only a few BrdU(+)/HCNP-pp(+) cells in the hippocampus in HI brains expressed the neuronal lineage marker, doublecortin (DCX). Interestingly, no BrdU(+)/HCNP-pp(+) progenitor cells in hypoxic, HI, or sham-operated brains expressed the astrocyte lineage marker, glial fibrillary acidic protein. Together with previous in vitro data, the results of this study suggest that the expression level of HCNP-pp regulates the differentiation of neural progenitor cells into specific neural lineages in the HI hippocampus, indicating that neural stem cell fate can be controlled via the HCNP-pp mediating pathway.
  • Comparoson of the radioisotope cisternography findings of spontaneous intracranial hypotension, Sakurai K, Nishio M, Yamada K, Shimohira M, Ozawa Y, Matsukawa N, Oguri T, Ueki Y, Cephalalagia, 32, (15) 1131 - 9,   2012年, 査読有り
  • Complications of Subthalamic Nucleus Stimulation in Parkinson's Disease, Atsushi Umemura, Yuichi Oka, Kenichi Yamamoto, Kenji Okita, Noriyuki Matsukawa, Kazuo Yamada, NEUROLOGIA MEDICO-CHIRURGICA, 51, (11) 749 - 755,   2011年11月, 査読有り, Subthalamic nucleus deep brain stimulation (STN-DBS) is effective for medically refractory Parkinson's disease. We retrospectively analyzed complications in 180 consecutive patients who underwent bilateral STN-DBS. Surgery-related complications were symptomatic intracerebral hemorrhage in 2, chronic subdural hematoma in 1, and transient deterioration of medication-induced psychosis in 2 patients. Device-related complications involved device infection in 5, skin erosion in 5, and implantable pulse generator malfunction in 2 patients. All of these patients required surgical repair. Surgery and device-related complications could be reduced with increased surgical experience and the introduction of new surgical equipment and technology. Treatment or stimulation-related complications were intractable dyskinesia/dystonia in 11, problematic dysarthria in 7, apraxia of eyelid opening (ALO) in 11, back pain in 10, and restless leg syndrome in 6 patients. Neuropsychiatric complications were transient mood changes in some, impulse control disorder in 2, severe depression related to excessive reduction of dopaminergic medications in 2, rapid progression of dementia in 1, and suicide attempts in 2 patients. Most complications were mild and transient. Dysarthria and ALO were the most frequent permanent sequelae after STN-DBS. Treatment-related adverse events may be caused not only by the effect of stimulation effect but also excessive reduction of dopaminergic medication, or progression of the disease. In conclusion, STN-DBS seems to be a relatively safe procedure. Although serious complications with permanent sequelae are rare, significant incidences of adverse effects occur. Physicians engaged in this treatment should have a comprehensive understanding of the probable complications and how to avoid them.
  • Subthalamic nucleus stimulation for Parkinson disease with severe medication-induced hallucinations or delusions., Umemura A, Oka Y, Okita K, Matsukawa N, Yamada K, J Neurosurg, 2011, (114) ,   2011年
  • Higher activity of peripheral blood angiotensin-converting enzyme is associated with late-onset of Alzheimer’s disease., Akatsu H, Ogawa N, Kanesaka T, Hori A, Yamamoto T, Matsukawa N, Michikawa M, J Neurol Sci, 300, (1-2) 67 - 73,   2011年01月
  • Reversible cerebral vasoconstriction syndrome in a patient with Takayasu’s arteritis., Uchida Y, Matsukawa N, Oguri T, Sakurai K, Miura T, Ojika K, Intern Med, 50, (15) 1611 - 1614,   2011年
  • Utility of the Fluid-Attenuated Inversion Recovery Sequence in Detecting a Hyperintense Putaminal Rim in Multiple System Atrophy-Parkinsonism: A Preliminary Study, Keita Sakurai, Takemori Yamawaki, Kenji Okita, Daisuke Kato, Noriyuki Matsukawa, Takatsune Kawaguchi, Susumu Kobayashi, Keiichi Nagai, Masahiro Muto, Akihiro Hosono, Yuta Shibamoto, EUROPEAN NEUROLOGY, 66, (1) 42 - 46,   2011年, 査読有り, Objective: To investigate the utility of fluid-attenuated inversion recovery (FLAIR) imaging for diagnosing multiple system atrophy-parkinsonism (MSA-P). Methods: We retrospectively evaluated 49 subjects (19 with MSA-P including 11 with early-stage disease, 15 with Parkinson's disease and 15 matched controls) in order to compare the diagnostic value of FLAIR imaging to detect a hyperintense putaminal rim (HPR) with that of T(2)-weighted (T2W) imaging. Results: Compared with T2W imaging, FLAIR imaging detected HPR more conspicuously in the 19 MSA-P patients (p = 0.01); this trend was also observed in 11 early-stage MSA-P patients (p = 0.01). Furthermore, FLAIR imaging tended to increase sensitivity of detecting HPR compared with T2W imaging (all patients: 89 vs. 58%, p = 0.07; early-stage patients: 100 vs. 55%, p = 0.06). Conclusions: FLAIR imaging might be more useful for detecting HPR in MSA-P patients, even though they are at an early stage. Copyright (C) 2011 S. Karger AG, Basel
  • Plaque valunerability in internal carotid arteries with positive remodeling., Miura T, Matsukawa N, Sakurai K, Katano H, Ueki Y, Okita K, Yamada K, Ojika K, Cerebrovasc Dis Extra, 1, (1) 54 - 65,   2011年, 査読有り
  • Predictive factors affecting early deterioration of axial symptoms after subthalamic nucleus stimulation in Parkinson's disease, Atsushi Umemura, Yuichi Oka, Kenji Okita, Takanari Toyoda, Noriyuki Matsukawa, Kazuo Yamada, PARKINSONISM & RELATED DISORDERS, 16, (9) 582 - 584,   2010年11月, 査読有り, Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment option for medically refractory Parkinson s disease (PD) However some patients show deterioration of axial symptoms within a short time after surgery We studied 43 patients who underwent bilateral STN-DBS and investigated predictive factors affecting early deterioration of axial symptoms Among 43 patients 16 patients showed obvious deterioration of axial symptoms within three years of surgery Multiple logistic regression analysis indicated that the significant independent variables related to early deterioration of axial symptoms were rapidly progressive short duration of the disease and advanced age at surgery These results suggest that patients with rapidly progressing PD who need early surgical intervention tend to show early deterioration of axial symptoms after STN-DBS (C) 2010 Elsevier Ltd All rights reserved
  • Predictive factors affecting early deterioration of axial symptoms after subthalamic nucleus stimulation in Parkinson's disease, Atsushi Umemura, Yuichi Oka, Kenji Okita, Takanari Toyoda, Noriyuki Matsukawa, Kazuo Yamada, PARKINSONISM & RELATED DISORDERS, 16, (9) 582 - 584,   2010年11月, Subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment option for medically refractory Parkinson s disease (PD) However some patients show deterioration of axial symptoms within a short time after surgery We studied 43 patients who underwent bilateral STN-DBS and investigated predictive factors affecting early deterioration of axial symptoms Among 43 patients 16 patients showed obvious deterioration of axial symptoms within three years of surgery Multiple logistic regression analysis indicated that the significant independent variables related to early deterioration of axial symptoms were rapidly progressive short duration of the disease and advanced age at surgery These results suggest that patients with rapidly progressing PD who need early surgical intervention tend to show early deterioration of axial symptoms after STN-DBS (C) 2010 Elsevier Ltd All rights reserved
  • Suppressed phosphorylation of collapsin response mediator protein-2 in the hippocampus of HCNP precursor transgenic mice, Tetsuko Kanamori, Noriyuki Matsukawa, Hatasu Kobayashi, Norihiko Uematsu, Takafumi Sagisaka, Takanari Toyoda, Daisuke Kato, Shinji Oikawa, Kosei Ojika, BRAIN RESEARCH, 1355, 180 - 188,   2010年10月, We previously reported a novel peptide, Hippocampal Cholinergic Neurostimulating Peptide (HCNP), which induces acetylcholine synthesis by increasing the amount of choline acetyltransferase (ChAT) in medial septal nuclei. The HCNP precursor protein (HCNP-pp), composed of 186 amino acids, is an inhibitory factor of the c-Raf/MEK cascade and may be involved in fetal rat brain development via the inhibition of phosphorylation of Erk. To clarify the involvement of HCNP in hippocampal cholinergic circuitry, we previously generated HCNP-pp transgenic (HCNP-pp Tg) mice using the promoter of the a subunit of Ca(2+) calmodulin-dependent protein kinase II (CaMKII alpha). These mice showed increased levels of ChAT in medial septal nuclei at 12 weeks of age, and the phenotype of depressive mood at 30 weeks of age. Here, through proteomic analysis we investigated the alteration of protein expression in the hippocampus of HCNP-pp Tg mice compared with wild-type littermate mice. We demonstrate that the activation of collapsin response mediator protein-2 (CRMP-2) is increased in the transgenic mice at 12 weeks of age when compared with wildtype littermate mice. (C) 2010 Elsevier B.V. All rights reserved.
  • Peri-hemorrhagic degeneration accompanies stereotaxic collagenase-mediated cortical hemorrhage in mouse, Tadashi Masuda, Mina Maki, Koichi Hara, Takao Yasuhara, Noriyuki Matsukawa, SeongJin Yu, Eunkyung Cate Bae, Naoki Tajiri, Sonia H. Chheda, Marianna Aurora Solomita, Nathan Weinbren, Yuji Kaneko, Sergei A. Kirov, David C. Hess, Hideki Hida, Cesar V. Borlongan, BRAIN RESEARCH, 1355, 228 - 239,   2010年10月, The cortex is a key brain region vulnerable to intracerebral hemorrhage (ICH) associated with stroke and head trauma. Animal models of ICH, via blood or collagenase infusion, have been developed most commonly to target the striatum. Here, we show that stereotaxic injection of collagenase type IV into two sites of the right cortex of adult C57BL6 mice produced hemorrhage to the cortex, subcortical white matter and hippocampus at day 1 post-injury, followed by cortical volume decrement by day 7. Reductions in MAP2- and NeuN-positive neurons were detected at day 1 and 7 post-injury in the core and peri-hemorrhagic cortex, respectively. Fluoro-Jade positive degenerating neurons were observed at day 1 in the pen-hemorrhagic area. An aberrant aggregation of GFAP-positive astrocytes and a significant reduction in RIP-positive oligodendroglial cells were detected at day 7 post-injury in the cortical area. In addition, a significant decrement in retrogradely Cholera Toxin Subunit B-labeled corticospinal neurons was recognized at day 14 post-injury in the ipsilateral cortex. Among the behavioral tests employed, the pole climb movement test robustly detected significant motor dysfunction at day 1, 3, and 7 post-injury that positively but inversely correlated with cortical volume at day 1 and 7 post-injury, respectively. The consistent observation of neuronal cell loss in the hemorrhagic core that subsequently extended to degeneration of neurons in the pen-hemorrhagic area, with accompanying motor abnormalities at least up to the subacute phase, advances this cortical hemorrhage model as a platform for examining the pathophysiology of and experimental treatments for ICH. (C) 2010 Elsevier B.V. All rights reserved.
  • HCNP precursor protein transgenic mice display a depressive-like phenotype in old age, Noriyuki Matsukawa, Yoshiaki Furuya, Hiroo Ogura, Kosei Ojika, BRAIN RESEARCH, 1349, 153 - 161,   2010年08月, We have previously reported a novel peptide, hippocampal cholinergic neurostimulating peptide (HCNP), which induces acetylcholine synthesis by increasing the amount of cholineacetyltransferase (ChAT) in medial septal nuclei. The HCNP precursor protein, composed of 186 amino acids, is an inhibitory factor of the c-Raf/ MEK cascade and may be involved in the development of the fetal rat brain via the inhibition of Erk phosphorylation. To clarify the involvement of HCNP in hippocampal cholinergic circuitry, we previously generated HCNP precursor protein (HCNP-pp) transgenic mice using the promoter of the a subunit of Ca(2+)-calmodulin-dependent protein kinase H (CaMKII alpha). These mice showed increased levels of ChAT in medial septal nuclei. Here, we investigated the behavioral phenotype of these mice, such as locomotor activity, mood and working/spatial memory. We demonstrate that HCNP-pp transgenic mice show a depressive-like phenotype at 30 weeks of age, but not at 12 weeks of age. We suggest that either HCNP and/or HCNP precursor protein may evoke the depressive-like phenotype via cholinergic hyperactivity from early neonatal life and/or inhibition of phosphorylated Erk in the neonatal hippocampus. (C) 2010 Elsevier B.V. All rights reserved.
  • Impaired ability to shift weight onto the non-paretic leg in right-cortical brain-damaged patients, Fumiyasu Ishii, Noriyuki Matsukawa, Mitsuya Horiba, Takehiko Yamanaka, Manabu Hattori, Ikuo Wada, Kosei Ojika, CLINICAL NEUROLOGY AND NEUROSURGERY, 112, (5) 406 - 412,   2010年06月, Background:: Stroke patients experience postural instability that can impede functional improvements in their gait. However, the precise functions of the dominant and non-dominant hemispheres in controlling static standing posture and weight-bearing remain unclear. Objective: : To investigate differences in balancing ability between right-handed patients with right and left hemispheric lesions. Methods: : Weight shifting was quantitatively evaluated to determine the ability of patients to control their balance in a static posture and during conscious weight shifting onto the paretic or non-paretic leg. Participants were enrolled from a consecutive series of stroke patients attending a rehabilitation program (n = 49; 31 male, 18 female; mean age 69.3 +/- 9.4 years). Age-matched normal controls were recruited as volunteers (n = 12; 4 male, 8 female; mean age 67.9 +/- 4.9 years). Results:: Patients with cortical lesions in the right hemisphere were able to shift less weight onto the non-paretic leg than patients with cortical lesions in the left hemisphere (p<0.05). There were no correlations between the existence of unilateral spatial neglect and the percentage of weight shifted onto the non-paretic leg, static standing posture (r=0.27, p = 0.40) or dynamic standing posture (r=-0.37, p = 0.24). In contrast, there was a significant correlation between the percentage of weight consciously shifted onto the non-paretic leg and the existence of anosognosia (r = 0.74, p = 0.006), but not between static standing posture and anosognosia (r=-0.15, p = 0.63). Conclusion: : Patients with right cortical hemispheric lesions were able to shift less body weight onto their non-paretic leg. These patients should be encouraged to practice shifting their weight towards their non-paretic leg to improve their balance. (C) 2010 Elsevier B.V. All rights reserved.
  • Pasteurella multocida meningitis caused by kissing animals: a case report and review of the literature, Shoji Kawashima, Noriyuki Matsukawa, Yoshino Ueki, Manabu Hattori, Kosei Ojika, JOURNAL OF NEUROLOGY, 257, (4) 653 - 654,   2010年04月
  • Directed neural lineage differentiation of adult hippocampal progenitor cells via modulation of hippocampal cholinergic neurostimulating peptide precursor expression, Takafumi Sagisaka, Noriyuki Matsukawa, Takanari Toyoda, Norihiko Uematsu, Tetsuko Kanamori, Hiroaki Wake, Cesario V. Borlongan, Kosei Ojika, BRAIN RESEARCH, 1327, 107 - 117,   2010年04月, Hippocampal cholinergic neurostimulating peptide (HCNP), originally purified from young rat hippocampus, has been known to promote the differentiation of septo-hippocampal cholinergic neurons. Recently, the precursor protein of HCNP (HCNP-pp) has also received attention as a multifunctional protein with roles, in addition to serving as the HCNP precursor, such as acting as an ATP-binding protein, a Raf kinase inhibitor protein (RKIP), and phosphatidylethanolamine-binding protein (PEBP). In particular, the function of RKIP has attracted attention over several years for its role in controlling cellular proliferation and metastasis in cancer cells. HCNP-pp is also thought to be important in regulating the proliferation and differentiation of neuronal cells in vitro and in vivo by modification of the MAPK cascade. In the present study, we used cultured adult rat hippocampal progenitor cells (AHPs), which are thought to be important for memory formation, and focused on the role of HCNP-pp in adult neurogenesis, namely, the production of new neurons from neural stem/progenitor cells. We found that HCNP-pp expression in AHPs was closely associated with differentiation into MAP2ab-positive neurons and RIP-positive oligodendrocytes, but not into GFAP-positive astrocytes. By contrast, a down-regulated HCNP-pp expression in AHPs accompanied differentiation into GFAP-positive astrocytes. Direct manipulations of HCNP-pp via viral over-expression or siRNA downregulation further confirmed the HCNP-pp contribution to specific neural lineage commitment of AHPs. Our results show that the expression level of HCNP-pp acts as a key regulator for differentiation of cultured AHPs into specific neural lineages, indicating that the control of neural stem cell fate can be achieved via the HCNP-pp pathway. (C) 2010 Elsevier B.V. All rights reserved.
  • Mannitol facilitates neurotrophic factor up-regulation and behavioural recovery in neonatal hypoxic-ischaemic rats with human umbilical cord blood grafts., Yasuhara T, Hara K, Maki M, Xu L, Yu G, Ali MM, Masuda T, Yu SJ, Bae EK, Hayashi T, Matsukawa N, Kaneko Y, Kuzmin-Nichols N, Ellovitch S, Cruz EL, Klasko SK, Sanberg CD, Sanberg PR, Borlongan CV, J Cell Mol Med, 14, (4) 914 - 921,   2010年
  • Notch-Induced Rat and Human Bone Marrow Stromal Cell Grafts Reduce Ischemic Cell Loss and Ameliorate Behavioral Deficits in Chronic Stroke Animals, Takao Yasuhara, Noriyuki Matsukawa, Koichi Hara, Mina Maki, Mohammed M. Ali, Seong Jin Yu, Eunkyung Bae, Guolong Yu, Lin Xu, Michael McGrogan, Krys Bankiewicz, Casey Case, Cesar V. Borlongan, STEM CELLS AND DEVELOPMENT, 18, (10) 1501 - 1513,   2009年12月, Gene transfection with Notch 1 intracellular domain and subsequent growth factor treatment stimulate neuron-like differentiation of bone marrow stromal cells (BMSCs). Here, we examined the potential of transplanting Notch-induced BMSCs to exert therapeutic effects in a rat model of chronic ischemic stroke. In experiment 1, Notch-induced rat BMSCs were intrastriatally transplanted in rats at 1 month after being subjected to transient occlusion of middle cerebral artery (MCAo). Compared to post-stroke/pretransplantation level, significant improvements in locomotor and neurological function were detected in stroke rats that received 100 k and 200 k BMSCs, but not in those that received 40 k BMSCs. Histological results revealed 9%-15% graft survival, which dose-dependently correlated with behavioral recovery. At 5 weeks post-transplantation, some grafted BMSCs were positive for the glial marker GFAP (about 5%), but only a few cells (2-5 cells per brain) were positive for the neuronal marker NeuN. However, at 12 weeks post-transplantation, where the number of GFAP-positive BMSCs was maintained (5%), there was a dramatic increase in NeuN-positive BMSCs (23%). In experiment 2, Notch-induced human BMSCs were intrastriatally transplanted in rats at 1 month following the same MCAo model. Improvements in both locomotor and neurological function were observed from day 7 to day 28 post-transplantation, with the high dose (180 k) displaying significantly better behavioral recovery than the low dose (90 k) or vehicle. There were no observable adverse behavioral effects during this study period that also involved chronic immunosuppression of all animals. Histological analyses revealed a modest 5%-7% graft survival, with few (<1%) cells expressing an intermediate MAP2 neuronal marker, but not glial or oligodendroglial markers. In addition, striatal peri-infarct cell loss was significantly reduced in transplanted stroke animals compared to vehicle-treated stroke animals. The present study demonstrates the potential of Notch-induced BMSC cell therapy for patients presenting with fixed ischemic stroke.
  • Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke, Noriyuki Matsukawa, Takao Yasuhara, Koichi Hara, Lin Xu, Mina Maki, Guolong Yu, Yuji Kaneko, Kosei Ojika, David C. Hess, Cesar V. Borlongan, BMC NEUROSCIENCE, 10,   2009年10月, Background: Minocycline, a second-generation tetracycline with anti-inflammatory and antiapoptotic properties, has been shown to promote therapeutic benefits in experimental stroke. However, equally compelling evidence demonstrates that the drug exerts variable and even detrimental effects in many neurological disease models. Assessment of the mechanism underlying minocycline neuroprotection should clarify the drug's clinical value in acute stroke setting. Results: Here, we demonstrate that minocycline attenuates both in vitro (oxygen glucose deprivation) and in vivo (middle cerebral artery occlusion) experimentally induced ischemic deficits by direct inhibition of apoptotic-like neuronal cell death involving the anti-apoptotic Bcl-2/cytochrome c pathway. Such anti-apoptotic effect of minocycline is seen in neurons, but not apparent in astrocytes. Our data further indicate that the neuroprotection is dose-dependent, in that only low dose minocycline inhibits neuronal cell death cascades at the acute stroke phase, whereas the high dose exacerbates the ischemic injury. Conclusion: The present study advises our community to proceed with caution to use the minimally invasive intravenous delivery of low dose minocycline in order to afford neuroprotection that is safe for stroke.
  • Anomaly in aortic arch alters pathological outcome of transient global ischemia in Rhesus macaques, Koichi Hara, Takao Yasuhara, Mina Maki, Noriyuki Matsukawa, Guolong Yu, Lin Xu, Laura Tambrallo, Nancy A. Rodriguez, David M. Stern, Tetsumori Yamashima, Jerry J. Buccafusco, Takeshi Kawase, David C. Hess, Cesario V. Borlongan, BRAIN RESEARCH, 1286, 185 - 191,   2009年08月, We investigated a non-human primate (NHP) transient global ischemia (TGI) model which was induced by clipping the arteries originating from the aortic arch. Previously we demonstrated that our TGI model in adult Rhesus macaques (Macaca mulatta) results in marked neuronal cell loss in the hippocampal region, specifically the cornu Ammonis (CA1) region. However, we observed varying degrees of hippocampal cell loss among animals. Here, we report for the first time an anomaly of the aortic arch in some Rhesus macaques that appears as a key surgical factor in ensuring the success of the TGI model in this particular NHP. Eleven adult Rhesus macaques underwent the TGI surgery, which involved 10-15-minute clipping of both innominate and subclavian arteries. Animals were allowed to survive between I day and 28 days after TGI. Because of our experience and knowledge that Japanese macaques exhibited only innominate and subclavian arteries arising from the aortic arch, macroscopic visualization of these two arteries alone in the Rhesus macaques initially assured us that clipping both arteries was sufficient to produce TGI. During the course of one TGI operation, however, we detected 3 arterial branches arising from the aortic arch, which prompted us to subsequently search for 3 branches in succeeding TGI surgeries. in addition, we performed post-mortem examination of the heart to confirm the number of arterial branches in the aortic arch. Finally, in order to reveal the pathological effect of the aortic arch anomaly, we compared the hippocampal cell loss between animals found to have 3 arterial branches but had all or only two branches clipped during TGI operation. Postmortem examination revealed that eight NHPs had the typical two arterial aortic branches, but three NHPs displayed an extra arterial aortic branch, indicating that about 30% of Rhesus macaques had 3 arterial branches arising from the aorta. Histological analyses using Nissl staining showed that in NHPs with the aortic arch anomaly clipping only two of three arterial branches led to a partial cell loss and minimal alteration in number of cell layers in the hippocampal region when compared with clipping all three branches, with the hippocampal cell death in the latter resembling the pathological outcome achieved by clipping the two arterial branches in NHPs displaying the typical two-artery aortic arch. The finding that 3 of 11 NHPs exhibited an extra arterial aortic branch recognizes this aortic arch anomaly in Rhesus macaques that warrants a critical surgical maneuver in order to successfully produce consistent TGI-induced hippocampal cell loss. (C) 2009 Elsevier B.V. All rights reserved.
  • Predicting the motor outcome of acute disseminated encephalomyelitis by apparent diffusion coefficient imaging: Two case reports, Shoji Kawashima, Noriyuki Matsukawa, Yoshino Ueki, Kentaro Yamada, Keita Sakurai, Takemori Yamawaki, Kosei Ojika, JOURNAL OF THE NEUROLOGICAL SCIENCES, 280, (1-2) 123 - 126,   2009年05月, We present two cases of young adults with acute disseminated encephalomyelitis (ADEM) who developed severe conscious and motor disturbances. Despite their similar initial clinical course and MRI findings, their motor function outcomes were quite different. In both cases, fluid attenuated inversion recovery (FLAIR) sequenced MRI showed multiple symmetric hyperintense lesions in the internal capsule and the brainstem at the subacute stage. However, in case 1 the apparent diffusion coefficient (ADC) was pathologically decreased in the internal capsule, whereas the ADC for case 2 was normal. At the end of the examination period, severe motor disability (bedridden state) with brain atrophy apparent on MRI remained in case 1, whereas case 2 made an almost full recovery without brain atrophy. These two cases suggest that altered ADC in the internal capsules at the subacute stage may reflect a different pathogenesis between cytotoxic and vasogenic edema, and may be a valuable indicator for the prognosis of motor disturbance. (C) 2009 Elsevier B.V, All rights reserved.
  • Analysis of DNA variations in promoter region of HCNP gene with Alzheimer’s disease., Okita K, Matsukawa N, Mina M, Nakazawa H, Katada E, Hattori M, Akatsu H, Borlongan CV, Ojika K, Biochem Biophys Res Comm, 379, (2) 272 - 276,   2009年02月
  • Gene over-expression of HCNP gene as heterozygous transgenic mice increases the amount of ChAT in medial septal nucleus., Uematsu N, Matsukawa N, Kanamori T, Arai H, Sagisaka T, Toyota T, Yoshida M, Ojika K, Brain Res, 1305, 150 - 157,   2009年
  • Hippocampal CA1 cell loss in a non-human primate model of transient global ischemia: A pilot study, Koichi Hara, Takao Yasuhara, Noriyuki Matsukawa, Mina Maki, Tadashi Masuda, Guolong Yu, Lin Xu, Laura Tambrallo, Nancy A. RodrigueZ, David M. Stern, Takeshi Kawase, Tetsurnori Yarnashima, Jerry J. Buccafusco, David C. Hess, Cesario V. Borlongan, BRAIN RESEARCH BULLETIN, 74, (1-3) 164 - 171,   2007年09月, 査読有り, We exposed adult Rhesus (Macaca mulatta) to a transient global ischemia, which was induced by clipping the innominate and subclavian arteries that originated from the aortic arch. NHP1 received 20-min, while NHP2 and NHP3, were exposed to a 15-min transient global ischemia and were euthanized at day 1 (NHP1), day 5 (NHP2) or day 30 (NHP3) after ischemia, respectively. NHPI displayed severe paralysis and rigidity, and intermittent convulsions over the next 24 h. Although histological examination of the brain revealed no detectable gross brain damage (i.e., swelling) and only minimal cell loss in the hippocampus, the acute survival time after surgery likely prevented the cerebral ischemia to fully develop and to be morphologically manifested. Nonetheless, the 20-min ischemia might have been too severe and caused a systemic multiple organ collapse that produced the abnormal behavioral symptoms. On the other hand, NHP2 and NHP3 which received 15-min ischemia. only exhibited minor hindlimb paralysis. Indeed, by 48 h after ischemia, both animals appeared fully recovered with only fine motor deficits. Immunohistochemical examination revealed that NHP2 and 3, but not NHP1, had a marked neuronal cell loss in the hippocampal region, specifically the cornu Ammonis (CA1) region. The cell loss in these two ischemic NHP hippocampi was further confirmed by direct comparison with a normal Rhesus brain. These findings replicate the brain pathology seen in Japanese macaques exposed to the same ischemia model [T. Tsukada, M. Watanabe, T. Yamashima, Implications of CAD and DNase 11 in ischemic neuronal necrosis specific for the primate hippocampus, J. Neurochem. 79 (2001) 1196-1206; T. Yamashima, Implication of cysteine proteases calpain, cathepsin and caspase in ischemic neuronal death of primates, Prog. Neurobiol. 62 (2000) 273-295; T. Yamashima, Y. Kohda, K. Tsuchiya, T. Ueno, J. Yamashita, T. Yoshioka, E. Kominami, Inhibition of ischemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on calpain-cathepsin hypothesis, Eur. J. Neurosci. 10 (1998) 1723-1733; T. Yamashima, T.C. Saido, M. Takita, A. Miyazawa, J. Yamano, A. Miyakawa, H. Nishijyo, J. Yamashita, S. Kawashima, T. Ono, T. Yoshioka, Transient brain ischemia provokes Ca2+, PIP2 and calpain responses prior to delayed neuronal death in monkeys, Eur. J. Neurosci. 8 (1996) 1932-1944; T. Yamashima, A.B. Tonchey, T. Tsukada, T.C. Saido, S. Imajoh-Ohmi, T. Momoi, E. Kominami, Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates, Hippocampus 13 (2003) 791-800]. The present minimally invasive transient global ischemia model using Rhesus shows many histopathological symptoms seen in human patients who experienced global ischemia, and should allow translational validation of experimental therapeutics for ischemic injury. Additional studies are warranted to reveal behavioral deficits associated with this ischemia model. (c) 2007 Elsevier Inc. All rights reserved.
  • [A case of neurolymphomatosis diagnosed with FDG-PET]., Hoshikawa Y, Oguri T, Hattori M, Uematsu N, Matsukawa N, Yamawaki T, Kusumoto S, Ojika K, Rinsho shinkeigaku = Clinical neurology, 47, (7) 437 - 440,   2007年07月, 査読有り
  • Early changes in KCC2 phosphorylation in response to neuronal stress result in functional downregulation, Hiroaki Wake, Miho Watanabe, Andrew J. Moorhouse, Takashi Kanematsu, Shoko Horibe, Noriyuki Matsukawa, Kiyofumi Asai, Kosei Ojika, Masato Hirata, Junichi Nabekura, JOURNAL OF NEUROSCIENCE, 27, (7) 1642 - 1650,   2007年02月, 査読有り, The K+ Cl- cotransporter KCC2 plays an important role in chloride homeostasis and in neuronal responses mediated by ionotropic GABA and glycine receptors. The expression levels of KCC2 in neurons determine whether neurotransmitter responses are inhibitory or excitatory. KCC2 expression is decreased in developing neurons, as well as in response to various models of neuronal injury and epilepsy. We investigated whether there is also direct modulation of KCC2 activity by changes in phosphorylation during such neuronal stressors. We examined tyrosine phosphorylation of KCC2 in rat hippocampal neurons under different conditions of in vitro neuronal stress and the functional consequences of changes in tyrosine phosphorylation. Oxidative stress (H2O2) and the induction of seizure activity (BDNF) and hyperexcitability (0 Mg2+) resulted in a rapid dephosphorylation of KCC2 that preceded the decreases in KCC2 protein or mRNA expression. Dephosphorylation of KCC2 is correlated with a reduction of transport activity and a decrease in [Cl-](i), as well as a reduction in KCC2 surface expression. Manipulation of KCC2 tyrosine phosphorylation resulted in altered neuronal viability in response to in vitro oxidative stress. During continued neuronal stress, a second phase of functional KCC2 downregulation occurs that corresponds to decreases in KCC2 protein expression levels. We propose that neuronal stress induces a rapid loss of tyrosine phosphorylation of KCC2 that results in translocation of the protein and functional loss of transport activity. Additional understanding of the mechanisms involved may provide means for manipulating the extent of irreversible injury resulting from different neuronal stressors.
  • Dietary supplementation of arachidonic and docosahexaenoic acids improves cognitive dysfunction, Susumu Kotani, Eiko Sakaguchi, Shogo Warashina, Noriyuki Matsukawa, Yoshiyuki Ishikura, Yoshinobu Kiso, Manabu Sakakibara, Tanihiro Yoshimoto, Jianzhong Guo, Tetsumori Yamashima, NEUROSCIENCE RESEARCH, 56, (2) 159 - 164,   2006年10月, 査読有り, Age-dependent increase of peroxidation of membrane fatty acids such as arachidonic acid (ARA) and docosahexaenoic acid (DHA) in neurons was reported to cause a decline of the hippocampal long-term potentiation (LTP) and cognitive dysfunction in rodents. Although supplementation of ARA and DHA can improve LTP and cognitive function in rodents, their effects in humans are unknown. The present work was undertaken to study whether ARA and DHA have beneficial effects in human amnesic patients. The subjects were 2 1 mild cognitive dysfunction (12 MCI-A with supplementation and 9 MIC-P with placebo), 10 organic brain lesions (organic), and 8 Alzheimer's disease (AD). The cognitive functions were evaluated using Japanese version of repeatable battery for assessment of neuropsychological status (RBANS) at two time points: before and 90 days after the supplementation of 240 mg/day ARA and DHA, or 240 mg/day of olive oil, respectively. MCI-A group showed a significant improvement of the immediate memory and attention score. In addition, organic group showed a significant improvement of immediate and delayed memories. However, there were no significant improvements of each score in AD and MCI-P groups. It is suggested from these data that ARA and DHA supplementation can improve the cognitive dysfunction due to organic brain damages or aging. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
  • Subtype analysis of neuropathologically diagnosed patients in a Japanese geriatric hospital, H Akatsu, M Takahashi, N Matsukawa, Y Ishikawa, N Kondo, T Sato, H Nakazawa, T Yamada, H Okada, T Yamamoto, K Kosaka, JOURNAL OF THE NEUROLOGICAL SCIENCES, 196, (1-2) 63 - 69,   2002年04月, 査読有り, Dementia is a social problem in Japan. as it is in other countries. Recently, there has been an increase in the number of patients with Alzheimer-type dementia (ATD) in the population. We analyzed 239 cases of patients autopsied at Fukushimura Hospital over a 10-year period. Clinicopathologically, 66% of these cases (158 cases) presented with dementia symptoms. The predominant form of illness was ATD. We found dementia with Lewy bodies (DLB) to be as frequent as vascular dementia (VD). Although the numbers were small, limbic neurofibrillary tangle dementia (LNTD) and Pick's disease (PiD) followed a clinical course typical of these diseases. On the other hand, senile dementia of the Alzheimer's type (SDAT) and the common form of neocortical type DLB (diffuse Lewy body disease; DLBD) were difficult to distinguish from each other. We attempted to uncover differences between these dementias in terms of how they affect male and female patients. The clinical course of the male patients with the common form of neocortical type DLB was more or less typical, while that of the female patients was not. (C) 2002 Elsevier Science B.V. All rights reserved.
  • Decreased expression of hippocampal cholinergic neurostimulating peptide precursor protein mRNA in the hippocampus in Alzheimer disease, M Maki, N Matsukawa, H Yuasa, Y Otsuka, T Yamamoto, H Akatsu, T Okamoto, R Ueda, K Ojika, JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 61, (2) 176 - 185,   2002年02月, 査読有り, Hippocampal cholinergic neurostimulating peptide (HCNP) is involved in the phenotype development of the septo-hippocampal system. HCNP precursor protein (HCNP-pp) is known to interact with other molecules including phosphatidylethanolamine and Raf-1 kinase, and is also known as phosphatidylethanolamine-binding protein and raf kinase-inhibitory protein. To assess whether HCNP-pp is involved in the pathogenesis of Alzheimer disease (AD), the expression levels of its mRNA in the hippocampus of autopsy brains from patients with dementia (including AD and ischemic vascular dementia) were compared with those of non-demented control subjects. The in situ hybridization analysis revealed that the expression of HCNP-pp mRNA in patients with clinically late-onset AD was decreased in the hippocampal CA1 field, but not in the CA3 field or the dentate gyrus. The early-onset AD patients showed a wide range of expression levels in the hippocampal sub-regions. Northern blot analysis of HCNP-pp mRNA in brain tissue supported these observations. Since HCNP is known to stimulate the enzymatic activity of choline acetyltransferase in neurons, its low expression in the CA1 field of AD patients may explain the downregulation of cholinergic neurons seen in these patients and may thus contribute to the pathogenic processes underlying AD.
  • Increased expression of hippocampal cholinergic neurostimulating peptide-related components and their messenger RNAs in the hippocampus of aged senescence-accelerated mice, N Matsukawa, Tooyama, I, H Kimura, T Yamamoto, Y Tsugu, Y Oomura, K Ojika, NEUROSCIENCE, 88, (1) 79 - 92,   1999年01月, Hippocampal cholinergic neurostimulating peptide stimulates cholinergic phenotype development by inducing choline acetyltransferase in the rat medial septal nucleus in vitro. Adult senescence-accelerated-prone mice/8, a substrain of the senescence-accelerated-prone mouse, show a remarkable age-accelerated deterioration in learning and memory. We cloned mouse hippocampal cholinergic neurostimulating peptide precursor protein complementary DNA. The deduced amino acid sequence showed that the neurostimulating peptide itself is the same as that found in the rat. In situ hybridization revealed that the highest expression of the precursor protein messenger RNA was in hippocampal pyramidal neurons. Compared with a strain of senescence-accelerated-resistant mouse (control mouse), adult senescence-accelerated-prone mice/8 showed increased expression of both the precursor messenger RNA and the neurostimulating peptide-related immunodeposits in the hippocampal CAI field. The deposits were intensely and diffusely precipitated in neuropils throughout the strata oriens and radiatum in senescence-accelerated-prone mice/8, but not in control mice. The neurostimulating peptide content in the hippocampus was higher in senescence-accelerated-prone mice/8 than in control mice, while its precursor protein itself was not different between the two strains. Furthermore, our previous and present data show that the medial septal and hippocampal choline acetyltransferase activity was significantly lower in senescence-accelerated-prone mice/8 than in control mice. The data suggest that, in hippocampal neurons in adult senescence-accelerated-prone mice/8, the production of hippocampal cholinergic neurostimulating peptide precursor protein in neuronal somata, which is associated with an increased expression of its messenger RNA in the CA1 held, occurs as a consequence of low activity in their presynaptic cholinergic neurons. This is followed by accelerated processing to generate bioactive peptide and transport to its functional fields. However, certain mechanisms reduce the release of the peptide and lead to its accumulation in the neuropil. These disturbances of the septohippocampal cholinergic system might be the biochemical mechanism underlying the characteristic deterioration of senescence-accelerated-prone mice/8. (C) 1998 IBRO. Published by Elsevier Science Ltd.

MISC

  • リーリンシグナルがアルツハイマー病発症に与える影響, 大嶋智葉, 山影祐子, 河野孝夫, 斎藤貴志, 西道隆臣, 赤津裕康, 松川則之, 服部光治, 次世代を担う若手ファーマ・バイオフォーラム講演要旨集, 17th,   2018年09月
  • リーリン機能低下がアルツハイマー病に与える影響の解明, 大嶋 智葉, 山影 祐子, 赤津 裕康, 松川 則之, 服部 光治, 生命科学系学会合同年次大会, 2017年度,   2017年12月
  • MCIとアルツハイマー病の血液バイオマーカーとしての補体タンパク質プロファイル, 劉 珊, 鈴木 秀昭, 目野 浩二, 赤津 裕康, 松川 則之, 新井 哲明, 朝田 隆, 内田 和彦, Dementia Japan, 31, (4) 610 - 610,   2017年10月
  • アルツハイマー病脳における補体C3の発現解析, 赤津 裕康, 鈴木 秀昭, 小川 倫弘, 兼坂 岳志, 橋詰 良夫, 松川 則之, 大原 弘隆, 朝田 隆, 内田 和彦, 補体, 52, (1) 58 - 58,   2015年08月
  • 視床下核脳深部刺激療法後のParkinson病における憂鬱気分効果(Depressive mood effects in Parkinson's disease after the deep brain stimulation of the subthalamic nucleus), 宮田 美和子, 梅村 淳, 坪井 理佳, 岡 雄一, 松川 則之, Nagoya Medical Journal, 54, (3) 111 - 117,   2015年05月
  • アルツハイマー病脳・血液のターゲットメタボロミクス解析, 井之上 浩一, 赤津 裕康, 土屋 浩史, 高山 卓大, 松川 則之, 橋詰 良夫, 山本 孝之, 豊岡 利正, JSBMS Letters, 39, (Suppl.) 72 - 72,   2014年09月
  • UHPLC‐MSを用いたアルツハイマー病の標的プロテオミクス/メタボロミクス統合解析, 山本誠, 井之上浩一, 赤津裕康, 松川則之, 橋詰良夫, 山本孝之, 豊岡利正, バイオメディカル分析科学シンポジウム講演要旨集, 27th,   2014年08月16日
  • アルツハイマー型認知症を対象としたメタボロミクス解析の応用, 井之上浩一, 赤津裕康, 土屋浩史, 高山卓大, 松川則之, 橋詰良夫, 山本孝之, 豊岡利正, バイオメディカル分析科学シンポジウム講演要旨集, 27th,   2014年08月16日
  • パーキンソン病における視床下核刺激療法の高次脳機能への長期的影響, 宮田 美和子, 坪井 理佳, 岡 雄一, 梅村 淳, 松川 則之, 高次脳機能研究, 34, (1) 67 - 68,   2014年03月
  • パーキンソン病における視床下核刺激療法の長期的影響, 宮田 美和子, 石井 文康, 山中 武彦, 梅村 淳, 松川 則之, 作業療法, 33, (1) 36 - 41,   2014年02月, パーキンソン病(以下、PD)の視床下核刺激療法(以下、STN DBS)の長期効果を検討した。対象は両側STN DBS術を施行され術後5年まで継続評価できたPD患者19例で、継続的なリハビリテーションは受けていない。術前、術後1ヵ月、1年、5年時にPD統一スケール(UPDRS)の評価を行った結果、日常生活動作(ADL)、運動機能は術後著明に改善し、その効果は1年後まで保たれていたが長期的には悪化した。一方、症状の日内変動やジスキネジアなどの運動合併症の改善やドパミン作動性薬剤服用量の減量は長期的にも維持された。STN DBS術後もADLや運動症状の悪化に対し継続的なリハビリテーションが必要と考えた。(著者抄録)
  • ヒト脳メタボローム解析によるアルツハイマー病低分子バイオマーカー探索研究, 井之上 浩一, 筒井 陽仁, 赤津 裕康, 橋詰 良夫, 松川 則之, 山本 孝之, 豊岡 利正, Dementia Japan, 27, (4) 480 - 480,   2013年10月
  • ヒト随意運動に関わる基底核-皮質運動野ループのfMRIおよびtractographyを用いた検討, 小栗 卓也, 澤本 伸克, 椨 勇人, 浦山 慎一, 松橋 眞生, 松川 則之, 小鹿 幸生, 福山 秀直, 臨床神経学, 52, (12) 1500 - 1500,   2012年12月
  • パーキンソン病講座 パーキンソン病における認知機能障害と自律神経障害との関連, 山下 豊, 松川 則之, 梅村 淳, 難病と在宅ケア, 18, (8) 49 - 51,   2012年11月
  • 大動脈炎症候群の治療経過中にReversible cerebral vasoconstriction syndrome(RCVS)を来たした1例, 打田 佑人, 小栗 卓也, 三浦 敏靖, 匂坂 尚史, 大喜多 賢治, 松川 則之, 小鹿 幸生, 岩垣津 志穂, 難波 大夫, 櫻井 圭太, 臨床神経学, 51, (6) 441 - 441,   2011年06月
  • プロテオミクス法を用いたHCNP Tg mouse海馬由来蛋白質組成の検討, 金森 哲子, 松川 則之, 上松 則彦, 匂坂 尚史, 豊田 剛成, 小鹿 幸生, 小林 果, 及川 伸二, 臨床神経学, 49, (12) 996 - 996,   2009年12月
  • プロテオミクス法を用いたHCNP Tg mouse海馬由来蛋白質組成の検討, 金森 哲子, 松川 則之, 上松 則彦, 匂坂 尚史, 豊田 剛成, 小林 果, 及川 伸二, 小鹿 幸生, Nagoya Medical Journal, 50, (3) 165 - 165,   2009年10月
  • 特発性正常圧水頭症の臨床病理学的研究, 松本 光弘, 小阪 憲司, 堀本 佳彦, 赤津 裕康, 山本 孝之, 松川 則之, 上田 龍三, 小鹿 幸生, Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2, (4) 289 - 294,   2002年12月
  • アルツハイマー病(AD)におけるHippocampal Cholinergic Neurostimulating Peptide(HCNP)前駆体蛋白mRNA発現の検討, 牧 美奈, 松川 則之, 湯浅 浩之, 山本 孝之, 赤津 裕康, 岡本 尚, 小鹿 幸生, 上田 龍三, 名古屋市立大学医学会雑誌, 53, (2〜3) 233 - 234,   2002年08月
  • アルツハイマー病(AD)におけるHippocampal Cholinergic Neurostimulating Peptide(HCNP)前駆体蛋白mRNA発現の検討, 牧 美奈, 松川 則之, 大塚 康史, 湯浅 浩之, 山本 孝之, 赤津 裕康, 小鹿 幸生, 上田 龍三, 臨床神経学, 41, (11) 984 - 984,   2001年11月

競争的資金

  • HCNPから視たCognitive researve分子メカニズムの解明, 日本学術振興会, 科学研究費 基盤C,   2017年 - 2019年
  • 難治性脊柱変形の病態解明と脊柱変形手術低侵襲化への集学的挑戦, 日本学術振興会, 科学研究費 基盤C,   2015年 - 2017年
  • 軽度認知障害及びアルツハイマー病の血液診断システム, 日本医療研究機構, A-STEP,   2012年 - 2016年
  • 粘膜に存在する認知症バイオマーカーの同定と鼻粘膜を用いた低侵襲的診断法の開発, 日本学術振興会, 科学研究費 挑戦的萌芽研究,   2014年 - 2015年
  • 平野小体・顆粒空胞変性形成過程におけるHCNP前駆体蛋白の働き, 日本学術振興会, 科学研究費 基盤C,   2013年 - 2015年


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