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加古 英介カコ エイスケ

所属部署医学研究科麻酔科学・集中治療医学分野
職名講師
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Last Updated :2020/05/26

研究者基本情報

学位

  • 博士

研究活動情報

研究分野

  • ライフサイエンス, 神経科学一般, グリア細胞
  • ライフサイエンス, 神経科学一般, グリア細胞

研究キーワード

    グリア細胞, 心臓血管麻酔

論文

  • Comparison of disinfection effect between benzalkonium chloride and povidone iodine in nasotracheal intubation: a randomized trial., Sato-Boku A, Nagano K, Hasegawa Y, Kamimura Y, Sento Y, So M, Kako E, Okuda M, Tachi N, Ito H, Adachi Y, Sobue K, BMC anesthesiology, 19, (1) ,   2019年08月, 査読有り
  • Necrotizing fasciitis following primary peritonitis caused by Streptococcus pyogenes with covS mutation in a healthy woman: a case report, Inoue M, Kako E, Kinugasa R, Sano F, Iguchi H, Sobue K, JA Clinical Reports, 29, (5) ,   2019年04月, 査読有り
  • General anesthetic management of a patient with multiple chemical sensitivity for oral surgery: a case report., Aiji Sato(Boku) A, Furuno S, Kamimura Y, Sento Y, Kako E, Okuda M, Shibuya Y, Sobue K, JA Clin Reports, 5, (10) ,   2019年, 査読有り
  • Peripheral Nerve Block Provides Effective Analgesia for a Patient With Peripheral Nerve Hyperexcitability Syndrome: Isaacs Syndrome Case Report., Asai A, Kako E, Hasegawa T, Sobue K, A&A practice,   2018年06月, 査読有り
  • General Anesthetic Management of a Child With Horseshoe Lung and Left Lung Hypoplasia for Cheiloplasty: A Case Report., Sato Boku A, Morita M, Ota H, Kamimura Y, Ito H, So M, Tamura T, Kako E, Harada J, Sobue K, A&A practice,   2018年04月, 査読有り
  • An analysis of the critical level of oxygen delivery during cardiopulmonary bypass, Kako E, Oda T, Yamazaki A, Koide Y, Cardiovascular Anesthesia, 22, (1) 67 - 71,   2018年, 査読有り
  • The usefulness of the McGrath MAC laryngoscope in comparison with Airwayscope and Macintosh laryngoscope during routine nasotracheal intubation: a randomaized controlled trial, Aiji Sato (Boku), Kazuya Sobue, Eisuke Kako, Naoko Tachi, Yoko Okumura, Mayuko Kanazawa, Mayumi Hashimoto, Jun Harada, BMC ANESTHESIOLOGY, 17, (1) ,   2017年12月, 査読有り, Background: McGrath MAC video laryngoscope offers excellent laryngosopic views and increases the success rate of orotracheal intubation in some cases. The aim of this study was to determine the usefulness of McGrath MAC for routine nasotracheal intubation by comparing McGrath MAC with Airway scope and Macintosh laryngoscope. Methods: A total of 60 adult patients with ASA physical status class 1 or 2, aged 20-70 years were enrolled in this study. Patients were scheduled for elective oral surgery under general anesthesia with nasotracheal intubation. Exclusion criteria included lack of consent and expected difficult airway. Patients were randomly allocated to three groups: McGrath MAC (n = 20), Airway scope (n = 20), and Macintosh laryngoscope (n = 20). After induction, nasotracheal intubation was performed by six expert anesthesiologists with more than 6 years of experience. Results: There were no significant differences in preoperative airway assessment among the three groups. Successful tracheal intubation time was 26.8 +/- 5.7 (mean +/- standard deviation) s for McGrath MAC, 36.4 +/- 11.0 s for Airway scope, and 36.5 +/- 8.9 s for Macintosh laryngoscope groups. The time for successful tracheal intubation for McGrath MAC group was significantly shorter than that for Airway scope and Macintosh laryngoscope (p < 0.01). McGrath MAC significantly improved the Cormack Lehane grade for nasotracheal intubation compared with Macintosh laryngoscope (p < 0.05). Conclusion: McGrath MAC significantly facilitates routine nasotracheal intubation compared with Airwayscope and Macintosh laryngoscope by shortening the tracheal intubation time and improving the Cormack Lehane grade.
  • エリスロポエチン派生物質による脳の修復と保護, 加古 英介, 金子 奈穂子, 祖父江 和哉, 澤本 和延, Nagoya Medical Journal, 55, (3) 129 - 135,   2017年06月
  • 重症度スコア(APACHE)IIと比較した予後指標としての血中乳酸値の臨床的有用性 レトロスペクティブ、観察的コホート研究(Clinical usefulness of blood lactate level as a prognostic indicator comparing with Acute Physiology and Chronic health Evaluation(APACHE) II scores: A retrospective, observational, cohort stud, 藤田 義人, 加藤 妙, 山内 浩揮, 加古 英介, 徐 民恵, 田村 哲也, 祖父江 和哉, Nagoya Medical Journal, 54, (3) 89 - 99,   2015年05月, 血中乳酸値の予後指標としての有用性について検討するために、APACHE IIスコアと入院時血中乳酸値との相関と、血中乳酸値と死亡率との関連を調べた。24ヵ月間連続して名古屋市立大学病院のICUに入院した連続患者856名の診療記録をレトロスペクティブに分析した。入院日の遅延、早期死亡、術後患者、幼児患者、入院時乳酸値の欠如などの患者を除外して、最終的に260名(男性147名、女性113名、67.5歳)を分析対象とした。入院時の血中乳酸値とAPACHE IIスコアの関係を散布図に示すと、y=1.17x+12.6でR2=0.344という中程度の相関を示す直線が得られた。乳酸値に応じて低乳酸群(<18mg/dl)の86名、中乳酸群(18〜36mg/dl)の75名、高乳酸群(36〜54mg/dl)の29名、超高乳酸群(>54mg/dl)の70名の4群に患者を分割した。各群の重度障害または死亡症例は、低乳酸群が10例(11.6%)、中乳酸群が22例(29.3%)、高乳酸群が10例(34.5%)、超高乳酸群が39例(55.7%)であり、乳酸値の増加に伴って有意な死亡率の上昇が認められた。
  • Enhancement of ventricular-subventricular zone-derived neurogenesis and oligodendrogenesis by erythropoietin and its derivatives, Naoko Kaneko, Eisuke Kako, Kazunobu Sawamoto, FRONTIERS IN CELLULAR NEUROSCIENCE, 7,   2013年11月, 査読有り, In the postnatal mammalian brain, stem cells in the ventricular-subventricular zone (V-SVZ) continuously generate neuronal and glial cells through out life. Genetic labeling of cells of specific lineages have demonstrated that the V-SVZ is an important source of the neuroblasts and/or oligodendrocyte progenitor cells (OPCs) that migrate toward injured brain are asin response to several types of insult, including ischemia and demyelinating diseases. However, this spontaneous regeneration is insufficient for complete structural and functional restoration of the injured brain, so interventions to enhance these processes are sought for clinical applications. Erythropoietin (EPO), a clinically applied erythropoietic factor, is reported to have cytoprotective effects in various kinds of insult in the central nervous system. Moreover, recent studies suggest that EPO promotes the V-SVZ-derived neurogenesis and oligodendrogenesis. EPO increases the proliferation of progenitors in the V-SVZ and/or the migration and differentiation of their progenies in and around injured areas, depending on the dosage, timing, and duration of treatment, as well as the type of animal model used. On the other hand, EPO has undesirable side effects, including thrombotic complications. We recently demonstrated that a 2-week treatment with the EPO derivative asialo-EPO promotes the differentiation of V-SVZ-derived OPCs into myelin-forming mature oligodendrocytes in the injured white matter of neonatal mice without causing erythropoiesis. Here we present an overview of the multifaceted effects of EPO and its derivatives in the V-SVZ and discuss the possible applications of these molecules in regenerative medicine.
  • Age-related requisite concentration of sevoflurane for adequate sedation with combined epidural-general anesthesia., Fujita Y, Kondo A, Yamauchi H, Kako E, Sobue K, Korean journal of anesthesiology, 64, (6) 489 - 493,   2013年06月, 査読有り
  • Human Dental Pulp-Derived Stem Cells Protect Against Hypoxic-Ischemic Brain Injury in Neonatal Mice, Mari Yamagata, Akihito Yamamoto, Eisuke Kako, Naoko Kaneko, Kohki Matsubara, Kiyoshi Sakai, Kazunobu Sawamoto, Minoru Ueda, STROKE, 44, (2) 551 - 554,   2013年02月, 査読有り, Background and Purpose-Perinatal hypoxia-ischemia (HI) has high rates of neurological deficits and mortality. So far, no effective treatment for HI brain injury has been developed. In this study, we investigated the therapeutic effects of stem cells from human exfoliated deciduous teeth (SHED) for the treatment of neonatal HI brain injury. Methods-Unilateral HI was induced in postnatal day 5 (P5) mice. Twenty-four hours later, SHED, human skin fibroblasts, or serum-free conditioned medium derived from these cells was injected into the injured brain. The effects of cell transplantation or conditioned medium injection on the animals' neurological and pathophysiological recovery were evaluated. Results-Transplanted SHED, but not fibroblasts, significantly reduced the HI-induced brain-tissue loss and improved neurological function. SHED also improved the survival of the HI mice. The engrafted SHED rarely differentiated into neural lineages; however, their transplantation inhibited the expression of proinflammatory cytokines, increased the expression of anti-inflammatory ones, and significantly reduced apoptosis. Notably, the intracerebral administration of SHED-conditioned medium also significantly improved the neurological outcome, inhibited apoptosis, and reduced tissue loss. Conclusions-SHED transplantation into the HI-injured brain resulted in remarkable neurological and pathophysiological recovery. Our findings indicate that paracrine factors derived from SHED support a neuroprotective microenvironment in the HI brain. SHED graft and SHED-conditioned medium may provide a novel neuroprotective therapy for HI. (Stroke. 2013;44:551-554.)
  • Subventricular Zone-Derived Oligodendrogenesis in Injured Neonatal White Matter in Mice Enhanced by a Nonerythropoietic Erythropoietin Derivative, Eisuke Kako, Naoko Kaneko, Mineyoshi Aoyama, Hideki Hida, Hirohide Takebayashi, Kazuhiro Ikenaka, Kiyofumi Asai, Hajime Togari, Kazuya Sobue, Kazunobu Sawamoto, STEM CELLS, 30, (10) 2234 - 2247,   2012年10月, 査読有り, Perinatal hypoxia-ischemia (HI) frequently causes white-matter injury, leading to severe neurological deficits and mortality, and only limited therapeutic options exist. The white matter of animal models and human patients with HI-induced brain injury contains increased numbers of oligodendrocyte progenitor cells (OPCs). However, the origin and fates of these OPCs and their potential to repair injured white matter remain unclear. Here, using cell-type- and region-specific genetic labeling methods in a mouse HI model, we characterized the Olig2-expressing OPCs. We found that after HI, Olig2+ cells increased in the posterior part of the subventricular zone (pSVZ) and migrated into the injured white matter. However, their oligodendrocytic differentiation efficiency was severely compromised compared with the OPCs in normal tissue, indicating the need for an intervention to promote their differentiation. Erythropoietin (EPO) treatment is a promising candidate, but it has detrimental effects that preclude its clinical use for brain injury. We found that long-term postinjury treatment with a nonerythropoietic derivative of EPO, asialo-erythropoietin, promoted the maturation of pSVZ-derived OPCs and the recovery of neurological function, without affecting hematopoiesis. These results demonstrate the limitation and potential of endogenous OPCs in the pSVZ as a therapeutic target for treating neonatal white-matter injury. STEM Cells2012;30:22342247
  • アシアロエリスロポエチンの脳低酸素虚血傷害に対する治療効果, 加古 英介, 金子 奈穂子, 青山 峰芳, 飛田 秀樹, 戸苅 創, 浅井 清文, 祖父江 和哉, 澤本 和延, Nagoya Medical Journal, 52, (2) 164 - 165,   2012年02月
  • Prospects and Limitations of Using Endogenous Neural Stem Cells for Brain Regeneration, Naoko Kaneko, Eisuke Kako, Kazunobu Sawamoto, GENES, 2, (1) 107 - 130,   2011年03月, 査読有り, Neural stem cells (NSCs) are capable of producing a variety of neural cell types, and are indispensable for the development of the mammalian brain. NSCs can be induced in vitro from pluripotent stem cells, including embryonic stem cells and induced-pluripotent stem cells. Although the transplantation of these exogenous NSCs is a potential strategy for improving presently untreatable neurological conditions, there are several obstacles to its implementation, including tumorigenic, immunological, and ethical problems. Recent studies have revealed that NSCs also reside in the adult brain. The endogenous NSCs are activated in response to disease or trauma, and produce new neurons and glia, suggesting they have the potential to regenerate damaged brain tissue while avoiding the above-mentioned problems. Here we present an overview of the possibility and limitations of using endogenous NSCs in regenerative medicine.
  • Promotion of neuronal migration towards the injured mouse cerebral cortex using sustained release of chemoattractant from gelatin hydrogel microspheres, Hiroshi Masuda, Naoko Kaneko, Eisuke Kako, Takao Hikita, Yasuhiko Tabata, Kazunobu Sawamoto, NEUROSCIENCE RESEARCH, 71, E338 - E339,   2011年, 査読有り
  • 疾病と再生医療 細胞移植を用いない脳疾患再生医療の可能性, 加古 英介, 金子 奈穂子, 祖父江 和哉, 澤本 和延, 生物物理化学, 53, (4) 103 - 107,   2009年12月
  • 帯状疱疹後神経痛の治療終了についての検討, 薊 隆文, 島田 靖子, 鈴木 悦子, 加古 英介, 高柳 猛彦, 井口 広靖, 播磨 恵, 春原 啓一, 大堀 久, 祖父江 和哉, 日本ペインクリニック学会誌, 16, (4) 518 - 519,   2009年09月
  • 血漿交換が有効であった顕微鏡的多発血管炎(MPA)の2重症例, 棚橋 順治, 加古 英介, 山内 浩揮, 加納 京子, 湯本 正人, 三浦 政直, 中村 不二雄, ICUとCCU, 29, (別冊) S202 - S204,   2005年02月
  • PMX-DHP Septic ARDSの肺酸素化能改善に対する長時間PMX-DHP療法の効果, 加古 英介, 三浦 政直, 棚橋 順治, 湯本 正人, 中村 不二雄, ICUとCCU, 28, (別冊) S205 - S207,   2004年02月, 症例は63歳男性で,咳,呼吸困難感が出現した.精査により,糖尿病ベースの重症肺炎と診断された.種々の治療により利尿は得られたが,肺酸素化能に対する反応性はきわめて不良で,搬送時,カットオフ値以下であったエンドトキシン値が高値を示すようになったことから,エンドトキシン除去を目的に長時間エンドトキシン吸着療法(PMX-DHP)療法を施行した.その結果,P/F比は人工呼吸器の条件,水分出納とは関連なく,PMX施行時間に比例して改善傾向を示したが,その後,人工呼吸器離脱困難となり,呼吸不全のため死亡した.一過性ではあったが,長時間のPMX-DHP施行は肺酸素化能に好影響をもたらす可能性が高いと思われた

MISC

  • 症例カンファレンス 悪性症候群既往とアレルギーがある患者のう歯治療, 加古 英介, 佐藤 會士, 高澤 知規, 前田 茂, 和田 圭伊子, LiSA, 26, (3) 201 - 216,   2019年03月, 招待有り
  • 血圧をあやつる, 加古 英介, 祖父江和哉, LiSA別冊秋号 血圧, 26,   2019年, 招待有り
  • 症例カンファレンス 冠動脈3枝病変を有する患者の進行性胃癌, 加古 英介, 下出 典子, 澤田 憲一朗, 藤田 信子, LiSA, 25, (5) 503 - 519,   2018年05月, 招待有り
  • 症例カンファレンス 慢性血栓塞栓性肺高血圧症合併患者の横行結腸癌手術, 加古 英介, 豊田 浩作, 西迫 良, 横山 健, 山本 俊介, LiSA, 25, (1) 17 - 31,   2018年01月
  • 体幹の痛みで発症したサルコイドーシスの一例, 徐 民恵, 杉浦 健之, 吉澤 佐也, 加古 英介, 平手 博之, 伊藤 彰師, 祖父江 和哉, 日本ペインクリニック学会誌, 18, (4) 406 - 406,   2011年09月
  • 採血後の疼痛が遷延した胸部交感神経切除術既往のある1症例, 加古 英介, 杉浦 健之, 平手 博之, 藤田 義人, 薊 隆文, 伊藤 彰師, 笹野 寛, 津田 喬子, 祖父江 和哉, 日本ペインクリニック学会誌, 15, (4) 429 - 429,   2008年09月
  • 救命し得た劇症型溶血性レンサ球菌感染症による四肢壊死性筋膜炎の1例, 古田 将, 三浦 政直, 加古 英介, 中村 不二雄, エンドトキシン血症救命治療研究会誌, 11, (1) 255 - 260,   2007年10月
  • 重症肺炎の肺酸素化能改善にPMX-DHP療法が関与したと考えられる2例, 三浦 政直, 加古 英介, 棚橋 順治, 湯本 正人, 中村 不二雄, エンドトキシン血症救命治療研究会誌, 8, (1) 147 - 153,   2004年11月

受賞

  •   2018年10月, 日本麻酔科学会 東海・北陸支部学術集会, 優秀演題賞, 腹腔鏡手術中の尿量は術後のAKIと相関しない
  •   2013年02月, 日本神経麻酔・集中治療研究会, 優秀演題賞, 脳低酸素虚血における白質障害と再生医療の可能性
  •   2012年12月, 名古屋市立大学医学会, 名古屋市立大学医学会賞, アシアロエリスロポエチンの新生児脳低酸素虚血障害に対する再生促進効果
  •   2012年03月, 名古屋市立大学大学院医学研究科, 優秀論文賞
  •   2011年, 日本集中治療学会, 優秀演題賞, 脳低酸素虚血における白質障害と再生医療の可能性
  •   2010年06月, 日本麻酔科学会, 優秀演題賞, 未熟児・先天性心疾患児におけるオリゴデンドロサイトの脆弱性

競争的資金

  • アストロサイトのカリウム制御メカニズムに注目した新規脳浮腫治療法の探索, 文部科学省, 科学研究費補助金 基盤研究C,   2017年 - 2019年
  • 周術期低酸素虚血後の脳白質傷害の発生期所解明と再生療法開発, 文部科学省, 科学研究費補助金 基盤研究C,   2013年 - 2015年
  • カルシウムイメージングを用いたグリア細胞再生メカニズムの解明, 公益財団法人 持田記念医学薬学振興財団, 留学補助金交付,   2013年04月 - 2014年03月
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