研究者データベース


フリーワードで探す

全文検索となっています

渋谷 恭之シブヤ ヤスユキ

所属部署医学研究科口腔外科学分野
職名教授
メールアドレス
ホームページURL
生年月日
Last Updated :2020/06/03

研究者基本情報

学歴

  • 1992年04月 - 1996年03月, 神戸大学, 大学院医学研究科
  • 1983年04月 - 1989年03月, 九州大学, 歯学部

学位

  • 博士(医学)

研究活動情報

研究キーワード

    顎変形症, インプラント, 口腔腫瘍

論文

  • Oral Care Evaluation to Prevent Oral Mucositis in Estrogen Receptor-Positive Metastatic Breast Cancer Patients Treated with Everolimus (Oral Care-BC): A Randomized Controlled Phase III Trial., Naoki Niikura, Katsuhiko Nakatukasa, Takeshi Amemiya, Ken-Ichi Watanabe, Hironobu Hata, Yuichiro Kikawa, Naoki Taniike, Takashi Yamanaka, Sachiyo Mitsunaga, Kazuhiko Nakagami, Moriyasu Adachi, Naoto Kondo, Yasuyuki Shibuya, Naoki Hayashi, Mariko Naito, Kosuke Kashiwabara, Toshinari Yamashita, Masahiro Umeda, Hirofumi Mukai, Yoshihide Ota, The oncologist,   2019年10月08日, 査読有り, BACKGROUND: The incidence of oral mucositis (any grade) after everolimus treatment is 58% in the general population and 81% in Asian patients. This study hypothesized that professional oral care (POC) before everolimus treatment could reduce the incidence of everolimus-induced oral mucositis. MATERIALS AND METHODS: This randomized, multicenter, open-label, phase III study evaluated the efficacy of POC in preventing everolimus-induced mucositis. Patients were randomized into POC and control groups (1:1 ratio) and received everolimus with exemestane. Patients in the POC group underwent teeth surface cleaning, scaling, and tongue cleaning before everolimus initiation and continued to receive weekly POC throughout the 8-week treatment period. Patients in the control group brushed their own teeth and gargled with 0.9% sodium chloride solution or water. The primary endpoint was the incidence of all grades of oral mucositis. We targeted acquisition of 200 patients with a 2-sided type I error rate of 5% and 80% power to detect 25% risk reduction. RESULTS: Between March 2015 and December 2017, we enrolled 175 women from 31 institutions, of which five did not receive the protocol treatment and were excluded. Over the 8 weeks, the incidence of grade 1 oral mucositis was significantly different between the POC group (76.5%, 62 of 82 patients) and control group (89.7%, 78 of 87 patients; p = .034). The incidence of grade 2 (severe) oral mucositis was also significantly different between the POC group (34.6%, 28 of 82 patients) and control group (54%, 47 of 87 patients; p = .015). As a result of oral mucositis, 18 (22.0%) patients in the POC group and 28 (32.2%) in the control group had to undergo everolimus dose reduction. CONCLUSION: POC reduced the incidence and severity of oral mucositis in patients receiving everolimus and exemestane. This might be considered as a treatment option of oral care for patients undergoing this treatment. Clinical trial identification number: NCT02069093. IMPLICATIONS FOR PRACTICE: The Oral Care-BC trial that prophylactically used professional oral care (POC), available worldwide, did not show a greater than 25% difference in mucositis. The 12% difference in grade 1 or higher mucositis and especially the ∼20% difference in grade 2 mucositis are likely clinically meaningful to patients. POC before treatment should be considered as a treatment option of oral care for postmenopausal patients who are receiving everolimus and exemestane for treatment of hormone receptor-positive, HER2-negative advanced breast cancer and metastatic breast cancer. However, POC was not adequate for prophylactic oral mucositis in these patients, and dexamethasone mouthwash prophylaxis is standard treatment before everolimus.
  • Drug holiday clinical relevance verification for antiresorptive agents in medication-related osteonecrosis cases of the jaw., Hayashida S, Yanamoto S, Fujita S, Hasegawa T, Komori T, Kojima Y, Miyamoto H, Shibuya Y, Ueda N, Kirita T, Nakahara H, Shinohara M, Kondo E, Kurita H, Umeda M, Journal of bone and mineral metabolism,   2019年08月, 査読有り
  • Effects of perioperative oral care on prevention of postoperative pneumonia after lung resection: Multicenter retrospective study with propensity score matching analysis., Iwata E, Hasegawa T, Yamada SI, Kawashita Y, Yoshimatsu M, Mizutani T, Nakahara H, Mori K, Shibuya Y, Kurita H, Komori T, Surgery, 165, (5) 1003 - 1007,   2019年05月, 査読有り
  • Medication-related osteonecrosis of the jaw after tooth extraction in cancer patients: a multicenter retrospective study., Hasegawa T, Hayashida S, Kondo E, Takeda Y, Miyamoto H, Kawaoka Y, Ueda N, Iwata E, Nakahara H, Kobayashi M, Soutome S, Yamada SI, Tojyo I, Kojima Y, Umeda M, Fujita S, Kurita H, Shibuya Y, Kirita T, Komori T, Japanese Study, Group of Co-operative Dentistry with Medicine (JCD, Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 30, (1) 231 - 239,   2019年01月, 査読有り
  • Sinus floor elevation with platelet-rich fibrin alone: A Clinical retrospective study of 1-7 years., Aoki N, Maeda M, Kurata M, Hirose M, Ojima Y, Wada K, Shibuya Y, Journal of clinical and experimental dentistry, 10, (10) e984 - e991,   2018年10月, 査読有り
  • Monosodium glutamate ingestion during the development period reduces aggression mediated by the vagus nerve in a rat model of attention deficit-hyperactivity disorder., Nishigaki R, Yokoyama Y, Shimizu Y, Marumoto R, Misumi S, Ueda Y, Ishida A, Shibuya Y, Hida H, Brain research, 1690, 40 - 50,   2018年07月, 査読有り
  • Treatment modalities and risk factors associated with refractory neurosensory disturbances of the inferior alveolar nerve following oral surgery: a multicentre retrospective study., Hasegawa T, Yamada SI, Ueda N, Soutome S, Funahara M, Akashi M, Furuno S, Miyamoto H, Hayashida S, Amano R, Mori K, Kojima Y, Kurita H, Kirita T, Umeda M, Shibuya Y, Fujita S, Komori T, Japanese Study, Group of Cooperative Dentistry with Medicine (JCD, International journal of oral and maxillofacial surgery, 47, (6) 794 - 801,   2018年06月, 査読有り
  • General Anesthetic Management of a Patient With Hypertrophic Cardiomyopathy for Oral Surgery: Did Digitalis Contribute to Bradycardia?, Sato Boku A, Morita M, So M, Tamura T, Sano F, Shibuya Y, Harada J, Sobue K, Anesthesia progress, 65, (3) 192 - 196,   2018年, 査読有り
  • Axial four-dimensional computed tomographic images to analyze crosswise differences in protrusive condylar movement in patients who underwent mandibulectomy and free flap reconstruction, Masaya Akashi, Toshinori Sekitani, Yumi Ohtsuki, Yasumasa Kakei, Junya Kusumoto, Takumi Hasegawa, Michinori Maeda, Noriyuki Negi, Kazunobu Hashikawa, Yasuyuki Shibuya, Satoru Takahashi, Takahide Komori, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 45, (11) 1778 - 1783,   2017年11月, 査読有り, Objective: Few studies evaluate condylar movement following mandibular reconstruction. The main objective of this study was to show that axial four-dimensional computed tomography (4DCT) could visualize bilateral protrusive condylar movement directly. We used axial 4DCT images to assess condylar protrusion in patients who underwent mandibular reconstruction. Methods: We enrolled seven healthy volunteers (median age 30 years, range 27-38 years) and seven patients (median age 65 years, range 52-80 years), who underwent mandibulectomy (segmental in five, hemi in one, marginal in one) and free flap reconstruction (using the fibula in six and the radial forearm in one). Six study subjects were instructed to masticate a cookie during the 4DCT scan (the seventh made chewing motions). The distance between the most anterior and posterior positions of the bilateral condyles on 4DCT (axial view) images was then measured and compared between controls and patients using the Manne-Whitney U-test. Results: The crosswise difference in the distances of condylar protrusion was significantly greater in patients than in the controls. Conclusion: Axial 4DCT images can visualize a bilateral condylar protrusive path. Axial 4DCT images for patients who have undergone mandibulectomy and reconstruction may be useful for evaluation of functional movement of condyles. (C) 2017 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • Evaluation of the Treatment Strategies for Medication-Related Osteonecrosis of the Jaws (MRONJ) and the Factors Affecting Treatment Outcome: A Multicenter Retrospective Study with Propensity Score Matching Analysis, Saki Hayashida, Sakiko Soutome, Souichi Yanamoto, Shigeyuki Fujita, Takumi Hasegawa, Takahide Komori, Yuka Kojima, Hironori Miyamoto, Yasuyuki Shibuya, Nobuhiro Ueda, Tadaaki Kirita, Hirokazu Nakahara, Mitsuyo Shinohara, Masahiro Umeda, JOURNAL OF BONE AND MINERAL RESEARCH, 32, (10) 2022 - 2029,   2017年10月, 査読有り, Medication-related osteonecrosis of the jaw (MRONJ) is an adverse event that may inhibit the treatment of primary disease and remarkably influence the patient's quality of life. The treatment methods for MRONJ, nonsurgical and surgical, are controversial, with no agreement as to which method provides the best outcome and should therefore be recommended. This multicenter retrospective study aimed to investigate the treatment methods and outcome in a large number of patients with MRONJ in Japan, utilizing propensity score matching analysis. A total of 361 patients with MRONJ, at eight hospitals, were registered in this study retrospectively. Various demographic and treatment-related variables were examined and analyzed to determine their correlation with the treatment outcome. After propensity score matching for treatment methods (nonsurgical versus surgical treatment), 176 patients were analyzed by logistic regression. It was shown that those with low-dose administration of an antiresorptive agent and surgical treatment had better outcomes. Furthermore, in 159 patients who underwent surgical treatment, those who underwent extensive surgery experienced significantly better treatment outcomes than those who underwent conservative surgery. This is the first study to compare treatment methods for MRONJ using propensity score matching analysis. The results indicated that extensive surgical treatment should be performed as first-choice therapy for patients with MRONJ. (C) 2017 American Society for Bone and Mineral Research.
  • Relationship between dental status and development of osteoradionecrosis of the jaw: a multicenter retrospective study, Yuka Kojima, Souichi Yanamoto, Masahiro Umeda, Yumiko Kawashita, Izumi Saito, Takumi Hasegawa, Takahide Komori, Nobuhiro Ueda, Tadaaki Kirita, Shin-ichi Yamada, Hiroshi Kurita, Yasuko Senga, Yasuyuki Shibuya, Hiroshi Iwai, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY, 124, (2) 139 - 145,   2017年08月, 査読有り, Objective. Osteoradionecrosis of the jaw is a serious late adverse event in patients with head and neck cancer undergoing radiotherapy. The aim of this study is to investigate the relationship between dental status and development of osteoradionecrosis. Study Design. Multicenter, retrospective observational study. A total of 392 patients with head and neck cancer who underwent radiotherapy were investigated for correlations between the development of osteoradionecrosis and various factors. The cumulative occurrence rate of osteoradionecrosis was calculated by the Kaplan-Meier method and analyzed by Cox regression and log-rank test. Results. Osteoradionecrosis developed in 30 of 392 patients. In 23 patients, osteoradionecrosis occurred in the mandibular molar region. A univariate analysis showed that oral or oropharyngeal cancer, jaw radiotherapy dose exceeding 50 Gy, periapical periodontitis, and tooth extraction after radiotherapy were significantly correlated with the occurrence of osteoradionecrosis. Among these, oral and oropharyngeal cancer, periapical periodontitis, and tooth extraction after radiotherapy were significant independent risk factors by multivariate analysis. Further, caries that occurred after radiotherapy and progressed rapidly, resulting in periapical periodontitis, carious stump, or extraction, was a major cause of osteoradionecrosis. Conclusion. Extraction of mandibular molars with periapical periodontitis before radiotherapy and strict dental management after radiotherapy may reduce the risk of osteoradionecrosis.
  • Effect of perioperative oral care on prevention of postoperative pneumonia associated with esophageal cancer surgery A multicenter case-control study with propensity score matching analysis, Sakiko Soutome, Souichi Yanamoto, Madoka Funahara, Takumi Hasegawa, Takahide Komori, Shin-ichi Yamada, Hiroshi Kurita, Chika Yamauchi, Yasuyuki Shibuya, Yuka Kojima, Hirokazu Nakahara, Takahiko Oho, Masahiro Umeda, MEDICINE, 96, (33) ,   2017年08月, 査読有り, The aim of this study was to investigate the effectiveness of oral care in prevention of postoperative pneumonia associated with esophageal cancer surgery. Postoperative pneumonia is a severe adverse event associated with esophageal cancer surgery. It is thought to be caused by aspiration of oropharyngeal fluid containing pathogens. However, the relationship between oral health status and postoperative pneumonia has not been well investigated. This study included 539 patients with esophageal cancer undergoing surgery at 1 of 7 university hospitals. While 306 patients received perioperative oral care, 233 did not. Various clinical factors as well as occurrence of postoperative pneumonia were retrospectively evaluated. Propensity-score matching was performed to minimize selection biases associated with comparison of retrospective data between the oral care and control groups. Factors related to postoperative pneumonia were analyzed by logistic regression analysis. Of the original 539 patients, 103 (19.1%) experienced postoperative pneumonia. The results of multivariate analysis of the 420 propensity score-matched patients revealed longer operation time, postoperative dysphagia, and lack of oral care intervention to be significantly correlated with postoperative pneumonia. The present findings demonstrate that perioperative oral care can reduce the risk of postoperative pneumonia in patients undergoing esophageal cancer surgery.
  • Multicenter Retrospective Study of the Risk Factors of Hemorrhage After Tooth Extraction in Patients Receiving Antiplatelet Therapy, Souichi Yanamoto, Takumi Hasegawa, Satoshi Rokutanda, Sayaka Komori, Akira Tachibana, Yuka Kojima, Yoshito Koyama, Yasuyuki Shibuya, Hiroshi Kurita, Takahide Komori, Masahiro Umeda, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 75, (7) 1338 - 1343,   2017年07月, 査読有り, Purpose: To identify the risk factors affecting hemorrhage after tooth extraction in patients receiving antiplatelet therapy, this study investigated the relation between various factors and hemorrhage events after tooth extraction. Patients and Methods: The records of 264 patients receiving antiplatelet therapy who underwent tooth extraction were retrospectively reviewed from 6 institutions belonging to the Japanese Study Group of Cooperative Dentistry with Medicine. Demographic information, hemorrhage events after tooth extraction, the presence or absence of comorbidities, antiplatelet agent, the use of preoperative antibiotics or nonsteroidal anti-inflammatory drugs, number of teeth extracted, serum creatinine level, estimated glomerular filtration rate, and alanine transaminase level were assessed. Risk factors for hemorrhage after tooth extraction were evaluated by univariate and multivariate analyses. Results: The study population of 264 patients consisted of 153 men and 111 women with a mean age of 73.6 years (range, 24 to 96 yr). Six hundred ninety-four teeth were extracted (mean, 2.6 +/- 2.3 teeth per patient). In patients receiving antiplatelet therapy, the frequency of hemorrhage after tooth extraction, including mild and self-controlled hemorrhages, was 17.4%. Univariate analysis showed that serum creatinine level and dual antiplatelet therapy were correlated with hemorrhage after tooth extraction (P = .001 and P = .049, respectively). Only serum creatinine was identified as an independent risk factor for hemorrhage after tooth extraction in patients receiving antiplatelet therapy (P = .037). Conclusions: The risk of hemorrhage after tooth extraction is increased in patients receiving dual antiplatelet therapy with or without chronic kidney disease. Local hemostatic treatments, such as at least suturing, are recommended. (C) 2017 American Association of Oral and Maxillofacial Surgeons
  • Intensity and duration of neutropenia relates to the development of oral mucositis but not odontogenic infection during chemotherapy for hematological malignancy, Megumi Kishimoto, Masaya Akashi, Kazuyuki Tsuji, Junya Kusumoto, Shungo Furudoi, Yasuyuki Shibuya, Yumiko Inui, Kimikazu Yakushijin, Shinichiro Kawamoto, Atsuo Okamura, Hiroshi Matsuoka, Takahide Komori, PLOS ONE, 12, (7) ,   2017年07月, 査読有り, Background D-index which combines the intensity and duration of neutropenia is reported as a tool for evaluating the dynamics of neutropenia. This study aimed to analyze the relationship between D-index and oral complications (i.e., oral mucositis [OM] and odontogenic infection [OI]) during chemotherapies for hematological malignancies. Methods A total of 421 chemotherapeutic courses in 104 patients were analyzed. Chemotherapeutic courses in patients who finished all of the prophylactic dental treatments were defined as "treatment Finish". Chemotherapeutic courses in patients who did not finish prophylactic dental treatments were defined as "treatment not-Finish". OM was evaluated according to the Common Terminology Criteria for Adverse Events, version 4.0. D-index was compared between chemotherapeutic courses with versus without oral complications. Results D-index was significantly higher in chemotherapeutic courses with grade 1 or 2 OM (p < 0.001) than courses without OM. In contrast, higher D-index did not relate to the development of OI (p = 0.18). The occurrence of OI (p < 0.001) but not OM (p = 0.56) during chemotherapy was significantly higher in chemotherapeutic courses without the completion of dental intervention. Conclusions Higher D-index relates to the development of OM. In contrast, OI occurs due to untreated odontogenic foci, and its occurrence does not relate to higher D-index.
  • The isoflavone fraction from soybean presents mRNA maturation inhibition activity, Masashi Kurata, Yuki Murata, Keiko Momma, Intisar Fouad Ali Mursi, Masakazu Takahashi, Yusaku Miyamae, Taiho Kambe, Masaya Nagao, Hiroshi Narita, Yasuyuki Shibuya, Seiji Masuda, BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81, (3) 551 - 554,   2017年03月, 査読有り, Recent findings indicate that mRNA splicing inhibitors can be potential anticancer candidates. We have previously established a screening system which monitors mRNA processing in order to identify mRNA processing inhibitors. Among a number of dietary resources, isoflavone fractions showed an inhibitory effect of mRNA processing. These findings demonstrate that a variety of dietary sources have an impact on mRNA biogenesis.
  • Inhibition of mRNA maturation by compounds which have a flavonoid skeleton., Kurata M, Morimoto M, Kawamura Y, Fouad Ali Mursi I, Momma K, Takahashi M, Miyamae Y, Kambe T, Nagao M, Narita H, Shibuya Y, Masuda S, Biochemistry and Molecular Biology., 2, (4) 46 - 53,   2017年, 査読有り
  • Prognosis of oral squamous cell carcinoma patients with level IV/V metastasis: An observational study, Takumi Hasegawa, Yasuyuki Shibuya, Daisuke Takeda, Eiji Iwata, Izumi Saito, Yasumasa Kakei, Akiko Sakakibara, Masaya Akashi, Tsutomu Minamikawa, Takahide Komori, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 45, (1) 145 - 149,   2017年01月, 査読有り, Purpose: The objectives of this study were to retrospectively describe the characteristics and outcomes of patients with oral squamous cell carcinoma (OSCC) with level IV/V metastases, and to evaluate the multivariate relationships among potential risk factors for metastasis and prognosis. Materials and methods: We evaluated 291 patients (178 men and 113 women; mean age, 65.9 +/- 13.5 years). Clinicopathological data, time of development of level IV/V metastases, and clinical course were investigated. Results: Twenty-three patients (7.9%) developed level IV/V metastases. The 3-year overall survival rates when level IV/V metastasis first developed were 27.3% upon initial treatment, 57.1% when metachronous neck metastasis developed, and 40.0% when the tumor recurred. Oral tongue tumor subsite, high N staging, neck dissection when metachronous neck metastasis developed, as well as recurrence were independent risk factors for level IV/V metastasis. Conclusion: We demonstrate here the multivariate relationships among the risk factors indicated above for level IV/V metastasis and their prognostic significance for patients with OSCC. Oral tongue tumors, high N staging, and neck dissection upon the occurrence of metachronous neck metastasis or recurrence were risk factors for level IV/V metastasis and positive extracapsular spread, presence of multiple lymph metastases, and moderate or poor differentiation were poor prognostic factors. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • Four-dimensional computed tomography evaluation of jaw movement following mandibular reconstruction: A pilot study, Masaya Akashi, Yasuyuki Shibuya, Satoru Takahashi, Kazunobu Hashikawa, Takumi Hasegawa, Yasumasa Kakei, Noriyuki Negi, Toshinori Sekitani, Takahide Komori, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 44, (5) 637 - 641,   2016年05月, 査読有り, Purpose: The purpose of this study was to analyze jaw movement during mastication in patients who underwent mandibular reconstruction following segmental mandibulectomy, including mouth opening and mastication time, based on four-dimensional computed tomography (4D CT) images. Material and methods: This study included six surgical patients, who underwent segmental mandibulectomy and simultaneous reconstruction with a free fibula osteocutaneous flap, and four controls. 4D CT was performed during mastication of a cookie to evaluate the movement of the jaw during natural function. The maximum mouth opening, mastication time, and movement of the mandibular angle during mastication were evaluated from the 4D CT images. Results: 4D CT images enabled visualization of jaw movement during mastication. When compared with the controls, the maximum mouth opening during mastication and excursion of the mandibular angle, especially on the diseased side, tended to decrease in surgical patients; however, this did not occur with mastication time. The numerical differences between the diseased and nondiseased side in surgical patients tended to be higher than the crosswise differences in controls. Conclusion: 4D CT images revealed differences in jaw function between patients who underwent mandibular reconstruction and controls. 4D CT could be used to evaluate postoperative outcomes following mandibular reconstruction. (C) 2016 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • Crestal Approach to Sinus Floor Elevation for Atrophic Maxilla Using Platelet-Rich Fibrin as the Only Grafting Material: A 1-Year Prospective Study, Takeo Kanayama, Koichiro Horii, Yasuko Senga, Yasuyuki Shibuya, IMPLANT DENTISTRY, 25, (1) 32 - 38,   2016年02月, 査読有り, Purpose: Platelet-rich fibrin (PRF) has been recently used as the sole grafting material in sinus floor elevation procedures. The aim of this prospective study was to measure the bone gain around the dental implant after using the crestal approach to sinus floor elevation using platelet-rich fibrin as the only grafting material in atrophic posterior maxillae with residual bone height <5 mm. Materials and Methods: Two different types of implants were used: hydroxyapatite (HA) and sandblasted acid-etched (SA) implants. Panoramic radiography and computed tomography were used to measure the endosinus bone gain. Results: Twenty-seven patients with 39 implants (19 HA and 20 SA) were included in this study. The mean residual bone measurements before surgery in the SA and HA groups were 2.85 and 2.68 mm, respectively. The mean average bone gains for 1 year in the SA and HA groups were 4.38 and 4.00 mm, respectively. Conclusion: This prospective study showed that platelet-rich fibrin promoted endosinus bone gain when used as the grafting material in the crestal approach to sinus floor elevation.
  • Sinus augmentation by platelet-rich fibrin alone: a report of two cases with histological examination., Aoki N, Kanayama T, Maeda M, Horii K, Miyamoto H, Wada K, Ojima Y, Tsuchimochi T, Shibuya Y, Case Reports in Dentistry., 2016, 1 - 7,   2016年, 査読有り
  • Postradiotherapy Dental Implant Insertion Into Bone Grafts Harvested From Nonirradiated Tissue: Case Reports, Akira Kimoto, Yasuyuki Shibuya, Masaki Kobayashi, Masaya Akashi, Takumi Hasegawa, Hiroaki Suzuki, Takahide Komori, IMPLANT DENTISTRY, 25, (5) 715 - 719,   2016年, 査読有り, Background: Prostheses and dental implants are often used to aid oral rehabilitation after surgery ( with/without radiotherapy) for oral cancer. However, some studies have reported that the insertion of dental implants into irradiated bone results in a higher frequency of implant failure than the insertion of such implants in nonirradiated bone. Materials and Methods: This report describes the cases of 4 patients with oral cancer who underwent surgery and radiotherapy ( total dose: 50-86 Gy) and then had dental implants inserted within the irradiated area. In each case, an ilium bone graft or a latissimus dorsi myocutaneous flap containing scapular bone was transferred to the dental implant site before the insertion of the implants. Results: Twenty-three implants were inserted. After loading, 2 implants were lost, and 21 remained stable. Conclusion: In patients who have undergone radiotherapy for oral cancer, transferring bone grafts harvested from nonirradiated tissue to the irradiated site before implant insertion might help to improve dental implant survival rates.
  • A comparison of radial forearm free-flap reconstruction and non-reconstruction after partial maxillectomy., Akashi M, Shibuya Y, Takahashi Y, Kusumoto J, Sakakibara A, Hasegawa T, Minamikawa T, Hashikawa K, Komori T, Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology., 28, 111 - 117,   2016年, 査読有り
  • CT Evaluation of Morphology of Transferred Fibula for Implant Placement in Reconstructed Mandible, Masaya Akashi, Yasuyuki Shibuya, Satoshi Wanifuchi, Junya Kusumoto, Akiko Sakakibara, Akira Kimoto, Takumi Hasegawa, Hiroaki Suzuki, Kazunobu Hashikawa, Takahide Komori, IMPLANT DENTISTRY, 24, (5) 541 - 546,   2015年10月, 査読有り, Background:Dental rehabilitation with osseointegrated implants in reconstructed mandibles remains one of the most challenging procedures for oral and maxillofacial surgeons. Satisfactory outcome requires appropriate assessment of graft morphology. There are few analyses of the morphology of fibulae in reconstructed mandibles, although cadaver studies on fibular shape have been performed.Materials and Methods:In this study, we used postoperative computed tomography to retrospectively evaluate the shape, height, and orientation of fibulae transferred after mandibulectomy in 19 patients.Results:The average height of transferred fibulae was 14.3 mm (range, 10.8-20.5 mm). The cross-sectional morphology of transferred fibulae could be classified into 2 types: apex and nonapex. The former type included knife-edged and triangular shapes; the latter included square and circular shapes.Conclusion:When implant insertion is planned in a reconstructed mandible, the orientation of the apex of transferred fibula should be evaluated preoperatively to allow for adjustments in implant procedure because the ridge at the apex of the fibula is narrow.
  • Assessing stomatognathic performance after mandibulectomy according to the method of mandibular reconstruction., Ishida S, Shibuya Y, Kobayashi M, Komori T, Int J Oral Maxillofac Surg., in press,   2015年
  • Prospective Study of Dental Intervention for Hematopoietic Malignancy., Tsuji K, Shibuya Y, Akashi M, Furudoi S, Yakushijin K, Kawamoto S, Okamura A, Matsuoka H, Komori T, Journal of Dental Research, 94, (2) 289 - 296,   2015年
  • Correlation between degree of bone invasion and prognosis in carcinoma of the mandibular gingiva: Soft tissue classification based on UICC classification., Matsushita Y, Yanamoto S, Yamada S, Mori H, Adachi M, Takahashi H, Naruse T, Ikeda H, Shiraishi T, Minamikawa T, Shibuya Y, Komori T, Asahina I, Umeda M, Journal of Oral and Maxillofacial Surgery, Medicine and Pathology., 27, (5) 631 - 636,   2015年, 査読有り
  • Spindle cell carcinoma of the oral cavity: the impact of chemotherapy on pulmonary metastatic tumor doubling time., Shigeta T, Minamikawa T, Matsui T, Kakei Y, Akashi M, Hasegawa T, Sakakibara A, Shibuya Y, Komori T, Kobe J Med Sci., 61, (3) E64 - E70,   2015年, 査読有り
  • Benefits of maxillectomy with internal dissection of the masticator space by transmandibular approach in the surgical management of malignant tumours of the upper gingiva and hard palate: a clinical review of 10 cases, S. Yanamoto, S. Yamada, H. Takahashi, T. Naruse, T. Shigeta, T. Minamikawa, Y. Shibuya, T. Komori, M. Umeda, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43, (11) 1319 - 1325,   2014年11月, The aim of this study was to review patients with tumours extending to the posterior portion of the upper gingiva and hard palate, and to evaluate the postoperative outcomes. Ten consecutive patients with tumours in the upper gingiva and hard palate, who underwent maxillectomy with internal dissection of the masticator space by the transmandibular approach, were reviewed retrospectively. Among the 10 patients, the pathological diagnosis was squamous cell carcinoma in seven, adenoid cystic carcinoma in one, malignant melanoma in one, and osteosarcoma in one. Loco-regional control was achieved in eight of nine patients (88.9%). Three patients had residual moderate trismus. Cosmetic issues were not noted in any patient. En bloc resection of the maxilla with the internal portion of the masticator space and neck through the parapharyngeal space by the transmandibular approach is a useful and satisfactory technique for the excision of a tumour with involvement of the posterior portion of the upper gingiva and hard palate.
  • Two cases of posterior open bite caused by the thickness of retrodiscal tissue in the temporomandibular joint, T. Hasegawa, Y. Shibuya, T. Minamikawa, T. Komori, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43, (9) 1104 - 1107,   2014年09月, There have been few reports of mouth closing disturbances in the final phase of occlusion caused by the posterior thickness of the retrodiscal tissue. Two such cases are described here. The first was a 70-year-old female suffering from a painless mouth closing disturbance on the right side of the temporomandibular joint (TMJ). She complained of a feeling like there was an air cushion. The second case was a 51-year-old male with a painless mouth closing disturbance on the left side of the TMJ. In both cases, magnetic resonance imaging (MRI) revealed enlargement of the posterior joint space on the affected side. The conditions of these two cases were improved by local injection of steroid preparations; however further additional treatments were required, including mandible traction in one case and dental prosthetics in the other. Consequently, we consider that the local injection of steroid preparations is useful as an initial treatment, while the use of local injection of steroid preparations alone is not sufficient for the treatment of posterior thickness of the retrodiscal tissue.
  • Transcutaneous Carbon Dioxide Induces Mitochondrial Apoptosis and Suppresses Metastasis of Oral Squamous Cell Carcinoma In Vivo, Daisuke Takeda, Takumi Hasegawa, Takeshi Ueha, Yusuke Imai, Akiko Sakakibara, Masaya Minoda, Teruya Kawamoto, Tsutomu Minamikawa, Yasuyuki Shibuya, Toshihiro Akisue, Yoshitada Sakai, Masahiro Kurosaka, Takahide Komori, PLOS ONE, 9, (7) ,   2014年07月, Squamous cell carcinoma (SCC) is the main histological type of oral cancer. Its growth rate and incidence of metastasis to regional lymph nodes is influenced by various factors, including hypoxic conditions. We have previously reported that transcutaneous CO2 induces mitochondrial apoptosis and decreases lung metastasis by reoxygenating sarcoma cells. However, previous studies have not determined the sequential mechanism by which transcutaneous CO2 suppresses growth of epithelial tumors, including SCCs. Moreover, there is no report that transcutaneous CO2 suppresses lymphogenous metastasis using human cell lines xenografts. In this study, we examined the effects of transcutaneous CO2 on cancer apoptosis and lymphogenous metastasis using human SCC xenografts. Our results showed that transcutaneous CO2 affects expressions of PGC-1 alpha and TFAM and protein levels of cleavage products of caspase-3, caspase-9 and PARP, which relatives mitochondrial apoptosis. They also showed that transcutaneous CO2 significantly inhibits SCC tumor growth and affects expressions of HIF-1 alpha, VEGF, MMP-2 and MMP-9, which play essential roles in tumor angiogenesis, invasion and metastasis. In conclusion, transcutaneous CO2 suppressed tumor growth, increased mitochondrial apoptosis and decreased the number of lymph node metastasis in human SCC by decreasing intra-tumoral hypoxia and suppressing metastatic potential with no observable effect in vivo. Our findings indicate that transcutaneous CO2 could be a novel therapeutic tool for treating human SCC.
  • Effects of postoperative chemotherapy and radiotherapy on patients with squamous cell carcinoma of the oral cavity and multiple regional lymph node metastases, H. Takahashi, S. Yanamoto, S. Yamada, M. Umeda, T. Shigeta, T. Minamikawa, Y. Shibuya, T. Komori, T. Shiraishi, I. Asahina, S. Yokoo, S. Ri, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43, (6) 680 - 685,   2014年06月, Nodal metastasis in oral squamous cell carcinoma (OSCC) is considered to be a predictor of a poor prognosis. The aim of this study was to investigate the relationship between the number of positive lymph nodes and the prognosis in OSCC patients with nodal metastases and to assess the effects of postoperative radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) on this patient group. A retrospective investigation of 98 patients with OSCC who underwent radical neck dissection and had at least three pathologically positive lymph nodes was performed. The 5-year disease-specific survival rate was 66.7% for patients with 3 positive nodes, while it was significantly lower for those with 4 positive nodes and those with >= 5 positive nodes (21.5% and 46.1%, respectively; P < 0.01). The loco-regional control and disease-specific survival rates for the surgery alone, surgery plus RT, and surgery plus CCRT groups were 46.2% and 40.5%, 66.3% and 54.4%, and 81.7% and 52.4%, respectively. For patients with >= 4 positive nodes, the loco-regional control rate after surgery plus CCRT was better than that observed after surgery alone (77.5% vs. 32.6%, P = 0.01). Postoperative RT and CCRT have positive impacts on the prognosis of OSCC patients with advanced stage neck disease.
  • Oral squamous cell carcinoma with microscopic extracapsular spread in the cervical lymph nodes, Y. Shibuya, Y. Ohtsuki, C. Hirai, T. Hasegawa, M. Akashi, T. Shigeta, T. Minamikawa, T. Komori, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43, (4) 387 - 392,   2014年04月, The purpose of this study was to determine the detailed background of cases of oral squamous cell carcinoma (OSCC) with microscopic extracapsular spread (ECS) in the cervical lymph nodes. The cases of 78 patients with primary OSCC, who attended hospital from October 2007 to July 2011 and underwent resection of the primary tumour with neck dissection, were reviewed. The subjects were classified into three categories: pN0, pN+/ECS-, and pN+/ECS+; the outcomes of pN+/ECS+ patients were compared in detail with those of the other categories. Thirty-one cases (39.7%) were pN0, 25 cases (32.1%) were pN+/ECS-, and 22 cases (28.2%) were pN+/ECS+. The 3-year overall survival rate was 82.1% in pN0, 74.1% in pN+/ECS-, and 39.8% in pN+/ECS+ (pN0 vs. pN+/ECS+, P = 0.0004; pN+/ECS- vs. pN+/ECS+, P = 0.0086). The 3-year disease-specific survival rate was 96.2% in pN0, 77.2% in pN+/ECS-, and 39.8% in pN+/ECS+ (pN0 vs. pN+/ECS+, P < 0.0001; pN+/ECS- vs. pN+/ECS+, P = 0.0038). Patients with poorly differentiated carcinoma, those with three or more ECS+ nodes, and those with ECS+ node(s) located at levels III, IV, and V, had the worst prognosis among pN+/ECS+ subjects.
  • The osteogenic activity of human mandibular fracture haematoma-derived cells is stimulated by low-intensity pulsed ultrasound in vitro, Y. Imai, T. Hasegawa, D. Takeda, M. Akashi, S. Y. Lee, T. Niikura, Y. Shibuya, M. Kurosaka, T. Komori, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 43, (3) 367 - 372,   2014年03月, Low intensity pulsed ultrasound (LIPUS) stimulation is a clinically established treatment method used to accelerate long bone fracture healing; however, this method is currently not applied to mandibular fractures. In this study, we investigated the effects of LIPUS on human mandibular fracture haematoma-derived cells (MHCs) in order to explore the possibility of applying LIPUS treatment to mandibular fractures. MHCs were isolated from five patients. The cells were divided into two groups: (1) LIPUS (+) group: MHCs cultured in osteogenic medium with LIPUS treatment; and (2) LIPUS () group: MHCs cultured in osteogenic medium without LIPUS treatment. The osteogenic differentiation potential and proliferation of the MHCs were compared between the two groups. The waveform used was equal to the wave conditions of a clinical fracture healing system. The gene expression levels of ALP, OC, Runx2, OSX, OPN, and PTH-R1 and mineralization were increased in the LIPUS (+) group compared to the LIPUS () group. There were no significant differences in cell proliferation between the two groups. These findings demonstrate the significant effects of LIPUS on the osteogenic differentiation of MHCs. This study provides significant evidence for the potential usefulness of the clinical application of LIPUS to accelerate mandibular fracture healing.
  • Outcomes and treatments of mal fractures caused by the split-crest technique in the mandible., Shibuya Y, Yabase A, Ishida S, Kobayashi M, Komori T, Kobe J Med Sci., 60, (2) E37 - 42.,   2014年
  • Sequential changes in oral dryness evaluated by a moisture-checking device in patients with oropharyngeal cancer during chemoradiotherapy: a pilot study., Nishii M, Akashi M, Kakei Y, Hasegawa T, Minamikawa T, Furudoi S, Shibuya Y, Takahashi M, Otsuki N, Nibu K, Komori T, Oral Health Dent Manag., 13, (2) 507 - 11,   2014年
  • Absence of the sternocleidomastoid muscle in a patient that underwent neck dissection for squamous cell carcinoma of the tongue., Takahashi H, Umeda M, Sakakibara A, Shigeta T, Minamikawa T, Shibuya Y, Komori T, Kobe J Med Sci., 59, (5) E167 - 71.,   2014年
  • Successive macroglossia after toxic epidermal necrolysis., Suzuki H, Shibuya Y, Enomoto Y, Kimoto A, Matsumoto K, Kakei Y, Komori T, Oral Science in Japan, 79 - 81.,   2014年
  • Changes in the sensitivity of cutaneous points and the oral mucosa after intraoral vertical ramus osteotomy, T. Hasegawa, C. Tateishi, M. Asano, N. Takata, M. Akashi, T. Shigeta, S. Furudoi, Y. Shibuya, T. Komori, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42, (11) 1454 - 1461,   2013年11月, In this study we investigated the changes in the sensitivity of cutaneous points and the oral mucosa that occur after intraoral vertical ramus osteotomy (IVRO). Additionally, postoperative changes in the sensitivity and the relationships between neurosensory disturbance and factors associated with IVRO operations were evaluated. An objective evaluation of the neurosensory status of cutaneous points and the oral mucosa of each patient was completed preoperatively and at 1, 2, 4, 8, 12, and 24 weeks postoperatively. The other variables studied for each patient included sex, age, magnitude of mandibular setback, and the amount of haemorrhage that occurred during surgery. In addition, the relationships between neurosensory disturbance and factors connected with IVRO operations were evaluated. We found that at cutaneous points, contributing factors such as sex, age, the magnitude of mandibular setback, and haemorrhage were associated with an increased risk of neurosensory disturbance after IVRO. However, these factors were not associated with that in the oral mucosa. In conclusion, we demonstrated the changes that occur in the sensitivity of cutaneous points and the oral mucosa after IVRO, the postoperative changes in sensitivity, and the relationships between neurosensory disturbance and factors connected with IVRO operations.
  • The observational study of delayed wound healing after tooth extraction in patients receiving oral bisphosphonate therapy, Takumi Hasegawa, Shinshou Ri, Masahiro Umeda, Hideki. Komatsubara, Masaki Kobayashi, Takashi Shigeta, Izumi Yoshitomi, Hisazumi Ikeda, Yasuyuki Shibuya, Izumi Asahina, Takahide Komori, JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, 41, (7) 558 - 563,   2013年10月, Introduction: In this study, we investigated whether such a discontinuation of oral bisphosphonate (BP) for 3 months might influence the incidence of BP-related osteonecrosis of the jaw (BRONJ) and wound healing after tooth extraction in patients receiving oral BP therapy. Material and methods: There were a total of 434 teeth in 201 patients (18 males and 183 females). The patients were divided into two groups depending on whether or not they underwent a 3-month discontinuation of BP therapy (BP- and BP+) before tooth extraction. In this observational study investigated delayed wound healing after tooth extraction in patients receiving oral BP therapy. Results: In all cases of the BP group, there were no BRONJ although there was delayed wound healing in two cases. However, in one case of the BP+ group, oral BP was continued because it was deemed high risk to discontinue treatment by the patient's physician. In this case, an intraoral fistula was still present with bone exposure at 120 weeks after extraction (BRONJ stage 1). Conclusion: This study supports the idea of a drug holiday and encourages further clinical research on this topic of tooth extraction in patients receiving oral BP therapy. (C) 2012 European Association for Cranio-Maxillo-Facial Surgery. Published by Elsevier Ltd. All rights reserved.
  • Observation of Osseous Healing After Intraoral Vertical Ramus Osteotomy: Focus on Computed Tomography Values, Satomi Arimoto, Takumi Hasegawa, Kotaro Kaneko, Chizu Tateishi, Shungo Furudoi, Yasuyuki Shibuya, Takahide Komori, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71, (9) 1602.e1 - 1602.e10,   2013年09月, Purpose: The purpose of this study was to observe long-term osseous healing of the cleavage space between bone fragments after intraoral vertical ramus osteotomy using computed tomographic (CT) values. Patients and Methods: CT examinations were performed to observe long-term osseous healing immediately after intraoral vertical ramus osteotomy and at 6 months, 1 year, and 2 years postoperatively. Bone fragments were observed on the interior and lateral sides. CT values between bone fragments were used to measure the range of each point within a 1.7- x 1.7-mm square, and the mean of the measurements was calculated. Results: CT values between bone fragments increased significantly over time at 1 month, 6 months, 1 year, and 2 years after surgery. Conclusions: Osseous healing in the cleavage between bone fragments after intraoral vertical ramus osteotomy was successful according to CT values. (C) 2013 American Association of Oral and Maxillofacial Surgeons
  • Risk factors associated with inferior alveolar nerve injury after extraction of the mandibular third molar-a comparative study of preoperative images by panoramic radiography and computed tomography, T. Hasegawa, S. Ri, T. Shigeta, M. Akashi, Y. Imai, Y. Kakei, Y. Shibuya, T. Komori, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 42, (7) 843 - 851,   2013年07月, In this study we investigated the relationships among the risk factors for inferior alveolar nerve injury (IANI), and the difference between preoperative imaging findings on panoramic radiographs and computed tomography (CT), by univariate and multivariate analyses. We determined the following to be significant variables by multivariate analysis: panoramic radiographic signs, such as the loss of the white line of the inferior alveolar canal or the diversion of the canal; excessive haemorrhage during extraction; and a close relationship of the roots to the IAN (type 1 cases) on CT examination. CT findings of type 1 were associated with a significantly higher risk (odds ratio 43.77) of IANI. In addition, many panoramic findings were not consistent with CT findings (275 of 440 teeth; 62.5%). These results suggest that CT findings may be able to predict the development of IANI more accurately than panoramic findings. Panoramic radiography alone did not provide sufficiently reliable images required for predicting IANI. Therefore, when the panoramic image is suggestive of a close relationship between the impacted tooth and the IAN, CT should be recommended as a means of conducting further investigations.
  • Oral Squamous Cell Carcinoma With Multiple Neck Metastases-Cases With More Than Ten Pathologically Positive Lymph Nodes in the Unilateral Side, Yasuyuki Shibuya, Takumi Hasegawa, Masaya Akashi, Takashi Shigeta, Tsutomu Minamikawa, Takahide Komori, JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 71, (4) 793 - 797,   2013年04月, Purpose: The purpose of this study is to know an outcome of the treatment for oral squamous cell carcinoma having more than 10 unilateral pathologically positive lymph nodes (pN)s. Patients and Methods: We reviewed 212 primary cases of oral squamous cell carcinoma that visited our hospital from January 1999 to December 2011 and underwent resection of the primary tumor with neck dissection. The patients were classified into 3 categories of pN0, pN1-9, and pN >= 10 cases, and an outcome of pN >= 10 was studied specifically in comparison with the other categories. Results: Of the patients studied, 103 cases (48.6%) were pN0, 103 cases (48.6%) were pN1-9, and 6 cases (2.8%) were pN >= 10. The pN >= 10 group, which had positive nodes of 10 to 30 on the ipsilateral side, was predominantly male and had no cases of well-differentiated squamous cell carcinoma. Extracapsular spread (ECS) was found in all pN >= 10 cases, and postoperative distant metastasis occurred in cases with ECS, which was localized in levels higher than III. The proportion of distant metastasis was 0% (0 cases) in pN0, 8.7% (9 cases) in pN1-9, and 66.7% (4 cases) in pN10. Overall survival rate in pN >= 10 was 20.8%, whereas it was 89.0% in pN0, and 34.9% in pN1-9. Conclusion: Oral squamous cell carcinoma having multiple neck metastases (pN >= 10) had a poor prognosis because the proportion of distant metastasis was higher in comparison with the other groups of pN0 and pN1-9. (C) 2013 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 71:793-797, 2013
  • Influence of preoperative dental procedures on the prognosis of patients with squamous cell carcinoma of the gingiva, Hidenori Takahashi, Masahiro Umeda, Yusuke Takahashi, Taiki Matsui, Takashi Shigeta, Tsutomu Minamikawa, Yasuyuki Shibuya, Takahide Komori, BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 51, (2) 108 - 112,   2013年03月, Our aim was to investigate the prognosis of patients with squamous cell carcinoma (SCC) of the gingiva who had preoperative dental operations. We studied 102 patients who were being operated on for SCC of the gingiva with special reference to the effects of preoperative dental operations on the prognosis. Twenty-six patients had dental procedures such as tooth extraction, or incision, or curettage before they visited our hospital, while the remaining 76 had no such interventions. The percentage of patients with advanced T stage disease (T3 or T4) was higher among those who had interventions (17/26, 65%) than among those who had not (35/76, 46%). The difference was not significant. Histopathologically invaded nodes were detected in half the patients in the intervention group (13/26), while they were found in only 18/76 (24%) of those in the no intervention group (p<0.02). The incidence of nodal metastases with extranodal spread was significantly higher in the intervention group than in the no intervention group (p<0.05), and those in the intervention group were more likely to develop distant metastases than those in the other group (p<0.001). The 5-year survival in the two groups was 65% and 92%, respectively (p<0.01). Preoperative dental operations such as tooth extraction, incision, or curettage possibly lead to regional and distant metastases and therefore a poor prognosis in patients with SCC of the gingiva. (C) 2012 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • Evaluation of masticatory function after maxillectomy using a colour-changing chewing gum, Y. Shibuya, S. Ishida, M. Kobayashi, T. Hasegawa, K. Nibu, T. Komori, JOURNAL OF ORAL REHABILITATION, 40, (3) 191 - 198,   2013年03月, The purpose of this study was to identify the risk factors associated with the masticatory dysfunction after maxillectomy using a colour-changing chewing gum. Thirty-nine patients who underwent maxillectomy between January 2002 and May 2010 in the Department of Kobe University Hospital were recruited for this study. There were 20 male and 19 female subjects, with a median age of 73 center dot 3years (range of 4490) at the time of surgery. The intra-oral conditions after maxillectomy were classified by HS classification, and the masticatory function was evaluated by a colour-changing chewing gum and the results of a modified Sato's questionnaire. The scores of the colour-changing gum were closely correlated with the scores of the modified Sato's questionnaire (r=0 center dot 661, P<0 center dot 01). A logistic regression analysis with the outcome variable of the gum test <4 demonstrated that significant predictors for the masticatory dysfunction were the number of anchor teeth 2 and a soft palate defect. A colour-changing gum was found to be useful for evaluating the post-operative masticatory function, and it was important to conserve the anchor teeth and the soft palate to avoid masticatory dysfunction.
  • Myelosuppression grading of chemotherapies for hematologic malignancies to facilitate communication between medical and dental staff: lessons from two cases experienced odontogenic septicemia., Akashi M, Shibuya Y, Kusumoto J, Furudoi S, Inui Y, Yakushijin K, Okamura A, Matsuoka H, Komori T, BMC Oral Health., 13,   2013年
  • Retrospective study of ameloblastoma: The possibility of conservative treatment., Hasegawa T, Imai Y, Takeda D, Yasuoka D, Ri S, Shigeta T, Minamikawa T, Shibuya Y, Komori T, Kobe J Med Sci, 59, (4) 112 - 121,   2013年
  • Tumefactive fibroinflammatory lesion presenting with head and neck fibrosclerosing lesions and orbital pseudotumors: A case report., Kusaka S, Nishimura S, Kawakami F, Ohbayashi C, Shibuya Y, Iwata K, J Med Case Rep., 7, (1) ,   2013年
  • Evaluation of masticatory function after mandibulectomy with colour-changing chewing gum., Shibuya Y, Ishida S, Hasegawa T, Kobayashi M, Nibu K, Komori T, J Oral Rehabil, 40, 484 - 490,   2013年
  • Prevention of Lingual Inclination of the Transport Segment in Vertical Distraction Osteogenesis in the Mandible, Shibuya Yasuyuki, Naoki Takata, Suguru Ishida, Junichiro Takeuchi, Masaki Kobayashi, Hiroaki Suzuki, Takahide Komori, IMPLANT DENTISTRY, 21, (5) 374 - 378,   2012年10月, Vertical distraction osteogenesis can extend not only to hard tissues but also to soft tissues. There is a tendency to cause progressive lingual inclination of the distracted segment. This study describes a method for preventing the lingual inclination of the transport segment in patients with vertical distraction osteogenesis in the anterior region of the mandible and reports the results of long-term follow-up. The subjects included 5 patients who had severely atrophic ridges in the anterior mandible. In all cases, a part of the mental protuberance was scraped out, and the distractor was placed suitably in a labioinclination beforehand. Therefore, the transport segments did not lean to the lingual side and had long-term stability. (Implant Dent 2012;21:374-378)
  • Maxillary Sinus Floor Elevation Combined With a Vertical Onlay Graft, Yasuyuki Shibuya, Yuka Takeuchi, Tomoko Asai, Junichiro Takeuchi, Hiroaki Suzuki, Takahide Komori, IMPLANT DENTISTRY, 21, (2) 91 - 96,   2012年04月, We performed maxillary sinus floor elevation combined with a vertical onlay graft for a total of 11 sides of nine patients (1 woman and 8 men) in our Hospital. On CT, the preoperative minimum alveolar bone thickness with a mean of 1.8 mm was improved to 15.3 mm within a month after this surgery. A total of 20 dental implants were placed and there was only one failed implant. With the average follow-up of 15.6 months, an average of 3.4 mm of bone absorption was found in the site of the maxillary sinus and 1.1 mm in the site of the onlay graft. The crown-implant ratio in all cases was within the permissible range. Consequently, this bone augmentation surgery was considered to be useful. (Implant Dent 2012;21:91-96)
  • Successful treatment with fluoropyrimidine TS-1 of human papillomavirus type 16-detected multiple oral bowenoid papulosis in an elderly woman, Eiji Nakano, Makoto Kunisada, Tetsuya Ikeda, Ayuko Kikusawa, Masashi Hirose, Yasuyuki Shibuya, Takahide Komori, Chikako Nishigori, EUROPEAN JOURNAL OF DERMATOLOGY, 22, (2) 267 - 268,   2012年03月
  • Analysis of the 619 Branemark System TiUnite Implants: A Retrospective Study., Shibuya Y, Takata N, Takeuchi J, Tsuji K, Ishida S, Hasegawa T, Kamae I, Komori T, Kobe Journal of Medical Sciences., 58, (1) E19 - E28,   2012年
  • Clinical evaluation of Lugol’s iodine staining in the treatment of stage I-II squamous cell carcinoma of the tongue., Umeda M, Shigeta T, Takahashi H, Minamikawa T, Komatsubara H, Oguni A, Shibuya Y, Komori T, Int J Oral Maxillofac Surg,, 40, (6) 593 - 596,   2011年06月
  • Osseous healing after a sagittal splitting ramus osteotomy, T. Hasegawa, C. Tateishi, R. Uchida, C. Nishi, S. Furudoi, Y. Shibuya, S. Yokoo, T. Komori, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 40, (5) 475 - 482,   2011年05月, The purpose of this study was to examine osseous healing in the cleavage between the bone fragments after sagittal splitting ramus osteotomy (SSRO) utilizing computed tomography (CT). The subjects were 13 patients with mandibular prognathism who underwent bilateral SSRO. CT was used to study the rami immediately after surgery, then 6 months, 1 year, and 2 years after surgery. Many concave type (the angle between the cleavage >90 degrees) anterior borders developed into the stairway type (the angle between the cleavage <90 degrees) 6-12 months after surgery. Few borders changed to the smooth type. Almost all of the stairway and concave posterior borders changed to the smooth type in the 6-12 months after surgery. Regarding the posterior borders 1 year after surgery, the cleavage of distal and proximal bone fragments demonstrated stable osseous healing (smooth type) in cases where the length and width between the bone fragments were large. In conclusion, the authors successfully demonstrated detailed osseous healing in the cleavage between the bone fragments after SSRO. Remodelling between bone fragments is a major mechanism of osseous healing after this procedure.
  • Shoulder mobility after spinal accessory nerve-sparing modified radical neck dissection in oral cancer patients, Masahiro Umeda, Takashi Shigeta, Hidenori Takahashi, Akiko Oguni, Tomoko Kataoka, Tsutomu Minamikawa, Yasuyuki Shibuya, Takahide Komori, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 109, (6) 820 - 824,   2010年06月, Objective. Radical neck dissection (RND), a standard surgical procedure for lymph node metastasis of head and neck cancer for decades, causes various dysfunctions, such as pain or limited abduction of the shoulder. Various RND modifications have been made to reduce these postoperative dysfunctions, but the effect of preservation of the spinal accessory nerve is still controversial. The aim of this study was to explain our surgical method of sparing the accessory nerve during neck dissection and to clarify the effect of preserving the nerve on reduction in shoulder dysfunction. Study design. One hundred five neck dissections were performed in 90 patients with oral cancer: 4 RNDs and 101 modified radical neck dissections (mRNDs). The spinal accessory nerve was preserved in 96 neck dissections. Dysfunction of the trapezius muscle was evaluated by the limitation of shoulder lateral abduction at 3 months after the operation. Results. All 9 patients with resection of the spinal accessory nerve showed severe shoulder dysfunction, whereas 90 out of 96 with preservation of the nerve maintained normal shoulder function. Conclusion. Spinal accessory nerve-sparing neck dissection can reduce postoperative shoulder dysfunction if careful operating procedures are used. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: 820-824)
  • A Case of malignant melanoma of the oral cavity alive with liver metastasis for a long period with administration of a biologic response modifier, OK432., Umeda M, Murata M, Suzuki H, Yanagida T, Shibuya Y, Komori T, Kobe Journal of Medical Sciences, 56, E140 - 147.,   2010年
  • Metastasis to the lateral retropharyngeal lymph node from squamous cell carcinoma of the oral cavity: Report of three cases, M. Umeda, T. Shigeta, H. Takahashi, T. Kataoka, A. Oguni, T. Minamikawa, Y. Shibuya, S. Yokoo, T. Komori, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 38, (9) 1004 - 1008,   2009年09月, Carcinoma of the oral cavity sometimes metastasizes to the lateral retropharyngeal lymph node (LRPLN), especially when posteriorly invading the soft palate or oropharynx. CT or MRI imaging has enabled detection of LRPLN metastasis in the early stage, but the prognosis of patients with metastasis to this node is extremely poor. The authors report three patients with squamous cell carcinoma of the oral cavity with no posterior invasion who developed metastasis to LRPLN during observation. The primary sites of these three cases were gingiva of the upper incisor region, gingiva of the lower premolar region, and maxillary bone of the upper incisor region. Each patient underwent surgery as their initial therapy, but a recurrent tumor in the LRPLN was detected by CT or MRI despite good loco-regional control. A salvage operation with postoperative radiation therapy was performed for two patients, but only one is still alive with no evidence of tumor 14 months after the last surgery. Management of LRPLN metastasis in oral cancer patients is a challenge for oral surgeons, but early detection by CT or MRI and surgery with postoperative radiation therapy is likely to yield the best local control.
  • Ror2 expression in squamous cell carcinoma and epithelial dysplasia of the oral cavity, Masaki Kobayashi, Yasuyuki Shibuya, Junichiro Takeuchi, Maho Murata, Hiroaki Suzuki, Satoshi Yokoo, Masahiro Umeda, Yasuhiro Minami, Takahide Komori, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 107, (3) 398 - 406,   2009年03月, In this study, the expressions of Ror2 in the normal mucosa, the epithelium dysplasia, and squamous cell carcinoma (SCC) of the oral cavity were investigated, and possible differences in the expression patterns of Ror2 and of p53, Ki67, or PCNA were examined. In Western blotting analyses, Ror2 expression in oral cancer was significantly higher than that in the normal oral mucosa. Immunohistochemically, Ror2 was localized on the plasmalemma and in the rough endoplasmic reticulum (rER). The tissue area with an Ror2-positive expression tended to differ from the area with a positive expression of p53, ki67, or PCNA, and the number of cells with an Ror2 expression tended to increase as the degree of malignancy rose in the epithelial tissues. These results suggest that Ror2 was not related to cell proliferation, but rather associated with cell polarity and cell motility, and that it was also closely associated with the degree of malignancy in oral epithelial tissue. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:398-406)
  • Analysis of 472 Branemark system TiUnite implants: A retrospective study., Shibuya Y, Kobayashi M, Takeuchi J, Asai T, Murata M, Umeda M, Komori T, Kobe Journal of Medical Sciences, 55, (3) 73 - 81.,   2009年
  • Effects of calcium phosphate cement on the peripheral nerve fibers., Munemoto S, Shibuya Y, Murata M, Takeuchi J, Ikehata N, Kobayashi M, Suzuki H, Umeda M, Komori T, Kobe Journal of Medical Sciences, 55, 98 - 105.,   2009年
  • Expression of beta-catenin and Integrin-linked kinase in the mouse sciatic nerve., Takeuchi J, Shibuya Y, Murata M, Komori T, Kobe Journal of Medical Sciences, 54, (4) 217 - 226.,   2008年
  • Treatment and prognosis of malignant melanoma of the oral cavity: preoperative surgical procedure increases risk of distant metastasis., Umeda M, Komatsubara H, Shigeta T, Ojima Y, Minamikawa T, Shibuya Y, Yokoo S, Komori T, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 106, 51 - 57.,   2008年
  • Two cases of masticator space abscess initially diagnosed as temporomandibular joint disorder., Hasegawa T, Shibuya Y, Kuroki S, Takeuchi J, Yokoo S, Umeda M, Komori T, Kobe Journal of Medical Sciences, 54, (3) 163 - 168.,   2008年
  • Myofibroma of the mandible., Shibuya Y, Takeuchi J, Sakaguchi H, Yokoo S, Umeda M, Komori T, Kobe Journal of Medical Sciences, 54, (3) E169 - 173.,   2008年
  • Alveolar ridge augmentation using various bone supplements -A web form of titanium fibers promotes the rapid bone development-., Masago H, Shibuya Y, Munemoto S, Takeuchi J, Umeda M, Kuboki Y, Komori T, Kobe Journal of Medical Sciences, 53, (5) 257 - 263.,   2007年
  • Clinical study on temporomandibular joint disorder -Analysis with the Japanese subtype classification-., Shibuya Y, Takeuchi J, Ikehata N, Akashi M, Fujita T, Yokoo S, Umeda M, Komori T, Kobe Journal of Medical Sciences, 53, (2) 63 - 70,   2007年
  • Orthognathic Surgery for Occlusal Reconstruction of Old Malunited Jaw Fracture., Ykoo S, Komori T, Furudoi S, Shibuya Y, Tateishi C, Hashikawa K, Tahara S, Hanagaki H, Kobe Journal of Medical Sciences, 52, (3) 37 - 47.,   2006年
  • Ultrastructural localization of alpha E-catenin in the rat sciatic nerve., Murata M, Shibuya Y, Munemoto S, Takeuchi J, Kobayashi M, Suzuki H, Komori T, Kobe Journal of Medical Sciences, 52, (3) 77 - 84.,   2006年
  • A comparison of brachytherapy and surgery for the treatment of stage I-II squamous cell carcinoma of the tongue, M Umeda, H Komatsubara, Y Ojima, T Minamikawa, Y Shibuya, S Yokoo, J Ishii, T Komori, INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 34, (7) 739 - 744,   2005年10月, The treatment method for early stage tongue cancer is still controversial in Japan. The aim of this study is to compare the prognosis for patients with early tongue cancer treated with brachytherapy and surgery. A retrospective study was conducted to compare the efficacy of low-dose-rate brachytherapy (LDR), high-dose-rate brachytherapy (HDR), and surgery for early tongue cancer. A total of 180 patients with stage I-II tongue cancer were divided into three treatment groups: LDR (78), HDR (26), and surgery (71). Local recurrence was seen in thirteen patients (17%) of the LDR, nine (35%) of the HDR, and four (6%) of the surgery group. After salvage therapy, final local cure was obtained for 71 patients (91%) of the LDR, 22 (85%) of the HDR, and 71 (100%) of the surgery group. Neck failure was recorded for eight patients in the LDR, six in the HDR, and three in the surgery group. The respective 5-year overall survival rates for the LDR, HDR and surgery groups were 84.0%, 72.9%, 95.4% for stage I, and 72.2%, 51.5%, 93.8% for stage II. These findings show that surgery is the optimal treatment method for patients with stage I-II tongue cancer.
  • En bloc resection of the primary tumour and cervical lymph nodes through the parapharyngeal space in patients with squamous cell carcinoma of the maxilla: a preliminary study, M Umeda, T Minamikawa, H Komatsubara, Y Ojima, Y Shibuya, S Yokoo, T Komori, BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY, 43, (1) 17 - 22,   2005年02月, We retrospectively studied 72 patients with maxillary carcinoma (48 of the gingiva, 22 of the antrum, and one each of the hard palate and maxillary bone). The 5-year survival was 73% for those with gingival carcinoma, and 45% for those with antral carcinoma. Nine patients died of local recurrence, three of cervical metastases, six of distant metastases, and five died of metastases in lateral retropharyngeal nodes despite successful control of local and regional disease. We have recently done en bloc resections of the maxilla and cervical lymph nodes through the parapharyngeal space for patients with posteriorly invasive maxillary cancer accompanied by Lymph node metastases in the upper jugular region. (C) 2004 The British Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
  • Lack of Survival Advantage in Patients with Advanced, Resectable Squamous Cell Carcinoma of the Oral Cavity Receiving Induction Chemotherapy with Cisplatin (CDDP), Docetaxel (TXT) and 5-Fluorouracil (5FU)., Umeda M, Komatsubara H, Ojima Y, Minamikawa T, Shigeta T, Shibuya Y, Yokoo S, Komori T, Kobe Journal of Medical Sciences, 50, (6) 189 - 196.,   2005年
  • N-/R-cadherin expression in dorsal root ganglia and spinal cord., Shibuya Y, Takeuchi J, Kobayashi M, Murata M, Munemoto S, Yokoo S, Umeda M, Komori T, Kobe Journal of Medical Sciences, 51, 35 - 40.,   2005年
  • Establishment and characterization of metastasizing cell lines from a heterotransplanted human adenoid cystic carcinoma, M Umeda, H Komatsubara, Y Ojima, T Minamikawa, Y Shibuya, S Yokoo, T Komori, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 98, (2) 211 - 216,   2004年08月, Adenoid cystic carcinoma (ACC) is a rare malignant tumor of the head and neck occurring in the salivary glands. We established a human ACC line which is serially transplantable in nude mice and designated it as KOA-1. The KOA-1 tumor doubled in 9.3 days and retained the histologic characteristics of a solid pattern of ACC even after 22 serial passages. The KOA-1 metastasized to the lung 2 months after subcutaneous transplantation into nude mice. We further established a subline of KOA-1 by an in vivo selection method and named it KOA-1L3. The KOA-1L3 doubled in 1.3 days and metastasized to the lung within 1 week after subcutaneous transplantation. These tumor lines may serve as a useful model for exploration of the biological behavior and treatment of human ACC.
  • Induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil for tongue cancer., Shibuya Y, Tanimoto H, Umeda M, Yokoo S, Komori T, Kobe Journal of Medical Sciences, 50, 1 - 7.,   2004年
  • Occulusal reconstruction: orthodontic techniques for treatment of jaw fracture., Yokoo S, Tateishi C, Furudoi S, Shibuya Y, Komori T, Hanagaki H, Moriyama K, World J Orthod, 5, 339 - 343.,   2004年
  • Constitutional mutation of keratin 13 gene in familial white sponge nevus, Y Shibuya, JM Zhang, S Yokoo, M Umeda, T Komori, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 96, (5) 561 - 565,   2003年11月, Objective. We sought to investigate a novel mutation in the keratin genes assumed to be responsible for a familial case of oral white sponge nevus. Patients and methods. The affected family consisted of a 36-year-old woman, her 17-year-old daughter, and her 14-year-old son. Keratin 4 and 13 genes extracted from venous blood lymphocytes were amplified by using the polymerase chain reaction and directly sequenced. Results. Sequencing analysis of the 3 patients revealed the presence of a novel heterozygous T-to-C transition mutation in exon 1 of the keratin 13 gene, with no abnormalities detected in the keratin 4 gene. Conclusion. We identified a novel heterozygous missense mutation at 332T>C in the keratin 13 gene believed to be related to the development of white sponge nevus.
  • Necrotizing fasciitis caused by dental infection: A retrospective analysis of 9 cases and a review of the literature, M Umeda, T Minamikawa, H Komatsubara, Y Shibuya, S Yokoo, T Komori, ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS, 95, (3) 283 - 290,   2003年03月, Objectives. Necrotizing fasciitis of the head and neck is an uncommon, potentially fatal soft tissue infection characterized by extensive necrosis and gas formation in the subcutaneous tissue and fascia. The aims of this study were to describe the condition of this rare disease and to find factors affecting the mortality. Study design. Nine of our new cases and 125 reported cases in the English-language literature with necrotizing fasciitis of dental origin were reviewed. Results. Two of our 9 patients had some form of systemic disease such as diabetes, cardiac insufficiency, renal failure, or cerebral infarction, whereas the other 7 had no particular general complications. A computed tomography examination was useful for detecting gas formation in the deep neck. All 9 patients underwent extensive debridement within 24 hours, and good results were obtained. In contrast, 24 of the 125 reviewed patients died despite therapy. Factors affecting the mortality were associated diseases such as diabetes or alcohol abuse, delay of surgery, and the complication mediastinitis. Conclusion. Necrotizing fasciitis is still a potentially fatal disease. Early and aggressive debridement may reduce mortality.
  • Central poorly differentiated adenocarcinoma of the maxilla : report of a case., Umeda M, Yokoo S, Shibuya Y, Komori T, Obayashi C, Kobe Journal of Medical Sciences, 49, 45 - 50.,   2003年
  • Indications for vascularized free rectus abdominis musculocutaneous flap in oromandibular region in terms of efficiency of anterior rectus sheath, S Yokoo, T Komori, S Furudoi, Y Shibuya, M Umeda, A Ichinose, T Nomura, H Terashi, S Tahara, KI Nibu, MICROSURGERY, 23, (2) 96 - 102,   2003年, The anterior rectus sheath, efficacious in reconstructive surgery, is used in oromandibular reconstruction with the free rectus abdominis musculocutaneous flap. This study describes reconstruction with this sheath in 20 patients: to preserve only the swallowing function in 10 patients (formation of the bulge of the reconstructed oral floor and prevention of its sinking); to preserve both swallowing and articulation in 5 patients (formation of the bulge of the reconstructed tongue and prevention of its sinking, concurrent with a money-pouch-like reconstruction of the tongue, laryngeal suspension, and neuroanastomosis); and to prevent exposure of the reconstruction plate, replacing the resected mandibular continuity in 5 patients. The purpose of reconstruction was achieved in all patients. The vascularized free rectus abdominis musculocutaneous flap with a firm anterior rectus sheath may be the first choice for these types of reconstruction.
  • A questionnaire on requests for disclosure of diagnosis, self-choice of treatment, and second opinion of patients with oral cancer in Japan., Umeda M, Komatsubara H, Minamikawa T, Furudoi S, Shibuya Y, Yokoo S, Komori T, J Palliat Care, 19, 206 - 208.,   2003年
  • Alpha E- and alpha N-catenin expression in dorsal root ganglia and spinal cord., Shibuya Y, Murata M, Munemoto S, Masago H, Takeuchi J, Wada K, Yokoo S, Umeda M, Komori T, Kobe Journal of Medical Sciences, 49, 93 - 98.,   2003年
  • Premalignant melanocytic dysplasia and malignant melanoma of the oral mucosa, M Umeda, H Komatsubara, Y Shibuya, S Yokoo, T Komori, ORAL ONCOLOGY, 38, (7) 714 - 722,   2002年10月, Although malignant melanoma of the oral cavity frequently arises in pre-existing, melanosis of the oral mucosa, little is known about oral melanoma precursor lesions. We reviewed three patients with premalignant melanocytic dysplasia and 14 with malignant melanoma of the oral mucosa. Thirteen of the 14 malignant melanoma cases had radial growth phases similar to those of acral lentiginous melanoma (ALM) of the skin. The prognosis of oral melanoma was not poor in contrast to that of cutaneous melanoma. Premalignant melanocytic dysplasia of the oral mucosa showed lentiginous or pagetoid proliferation of atypical melanocytes in the lower epithelium in the central part of the lesion, and lentiginous proliferation of dendritic melanocytes or simple hyperpigmentation in the basal cell layer in the peripheral part. These findings were similar to those of the radial growth phase of ALM of the oral mucosa. (C) 2002 Elsevier Science Ltd. All rights reserved.
  • Carotid body tumour., Shibuya Y, Umeda M, Yoshikawa T, Komori T, Oral Oncol, 38, 313 - 317.,   2002年
  • Evaluation of T-classifications of upper gingival and hard palate carcinomas- a proposition for new criterion of T4., Yokoo S, Umeda M, Komatsubara H, Shibuya Y, Komori T, Oral Oncol, 38, 378 - 382.,   2002年
  • Establishment and characterization of a human adenoid cystic carcinoma line of the salivary gland which is serially transplantable and spontaneously metastasises to the lung in nude mice., Umeda M, Komatsubara H, Nishimatsu N, Oku N, Shibuya Y, Yokoo S, Komori T, Oral Oncol, 38, 30 - 34.,   2002年
  • Indications and procedures for segmental dentoalveolar osteotomy : A review of 13 patients., Yokoo S, Komori T, Watatani S, Shibuya Y, Komurasaki H, Tateishi C, Int J Adult Orthod Orthognath Surg, 17, 254 - 263.,   2002年
  • Experimental model of invasion and metastasis by orthotopic transplantation of oral squamous and adenoid cystic carcinomas into the tongue of nude mice., Umeda M, Yokoo S, Komori T, Nishimatsu N, Shibuya Y, Fujioka M, Br J Oral Maxillofac Surg, 39, 376 - 380.,   2001年
  • Expression of R-cadherin in the regenerating chick sciatic nerve., Shibuya Y, Yasuda H, Umeda M, Komori T, Ide C, Anat Embryol, 204, 485 - 491,   2001年
  • Spindle cell squamous carcinoma of the maxilla: Report of a case with immunohistochemical analysis., Shibuya Y, Umeda M, Yokoo Y, Komori T, J Oral Maxillofac Surg, 58, 1164 - 1169.,   2000年
  • The role of radiotherapy for patients with adenoid cystic carcinoma of the salivary gland., Umeda M, Nishimatsu N, Yokoo S, Shibuya Y, Fujioka M, Komori T, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 89, 724 - 729.,   2000年
  • High dose rate (HDR) interstitial brachytherapy for stage I-II tongue cancer., Umeda M, Komatsubara H, Nishimatsu N, Yokoo S, Shibuya Y, Komori T, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 90, 667 - 670.,   2000年
  • Tumor doubling time and onset of pulmonary metastasis from adenoid cystic carcinoma of the salivary gland., Umeda M, Nishimatsu N, Masago H, Ishida Y, Yokoo S, Fujioka M, Shibuya Y, Komori T, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 88, 473 - 478.,   1999年
  • Ultrastructural localization of E-cadherin and a-/ß-catenin in the adenoid cystic carcinoma., Shibuya Y, Ri S, Umeda M, Yoshikawa T, Masago H, Komori T, Histopathology, 35, 423 - 431,   1999年
  • alpha N-catenin expression in the normal and regenerating chick sciatic nerve, Y Shibuya, H Yasuda, M Tomatsuri, A Mizoguchi, M Takeichi, K Shimada, C Ide, JOURNAL OF NEUROCYTOLOGY, 25, (11) 615 - 624,   1996年11月, The Ca2+-dependent intercellular adhesion molecule cadherin is known to be linked to the cytoskeleton by the protein catenin, an association of which appears to be important for the cell-adhesion function of cadherin. Catenin consists of three subtypes-alpha, beta, and gamma. In our previous study, N-cadherin was shown to be localized on the plasmalemma of normal and regenerating chick peripheral nerve. Thus, as alpha N-catenin is a subtype of alpha-catenin (which is specifically associated with N-cadherin), we investigated the immunolocalization of alpha N-catenin in normal and regenerating chick sciatic nerve. In normal nerve, unmyelinated axons exhibited either intense or weak alpha N-catenin immunoreactivity throughout the axoplasm, whereas myelinated axons were completely immunonegative. Regenerating axons, including those derived from parent myelinated axons, showed alpha N-catenin immunoreactivity of variable intensities in growth cones and axon shafts. Schwann cells were invariably devoid of immunoreactivity. Thus alpha N-catenin is not necessarily bound to the surface plasmalemma, but is distributed throughout the cytoplasm, suggesting that most alpha N-catenin molecules are dissociated from N-cadherin.
  • LOCALIZATION OF N-CADHERIN IN THE NORMAL AND REGENERATING NERVE-FIBERS OF THE CHICKEN PERIPHERAL NERVOUS-SYSTEM, Y SHIBUYA, A MIZOGUCHI, M TAKEICHI, K SHIMADA, C IDE, NEUROSCIENCE, 67, (1) 253 - 261,   1995年07月, The localization of N-cadherin in the normal, and regenerating nerve fibers was investigated by immunocytochemistry in the chicken sciatic nerve. The normal unmyelinated fibers exhibited N-cadherin immunoreactivity on the plasma membranes of axons and Schwann cells where they were in contact with each other, while myelinated fibers displayed no immunoreactivity except at the mesaxon where Schwann cell plasma membranes were attached to each other. In the regenerating nerves, intense immunoreactivity was demonstrated on the surface of plasma membranes of axons and Schwann cells where axon-axon and axon-Schwann cell contacts were made. No immunoreactivity was observed on the plasma membranes where regenerating axons or Schwann cells were in touch with the basal lamina. In addition, it was revealed that some vesicles in the growth cones had distinct N-cadherin immunoreactivity at the inner limiting membrane surface. These findings indicate that N-cadherin may be involved in the axon-axon and axon-Schwann cell adhesion in the normal unmyelinated as well as regenerating nerve fibers, and also in the attachment of Schwann cell processes at the mesaxon of myelinated fibers. In addition, these findings suggest that N-cadherin might be, at least in part, Supplied by fusion of growth cone vesicles with the surface plasma membranes in growing axons.

書籍等出版物

  • エビデンスに基づいた周術期口腔機能管理, 渋谷 恭之, 分担執筆, 医歯薬出版,   2018年10月
  • 日常の口腔外科 第二版, 渋谷 恭之, 分担執筆, 永末書店,   2018年03月
  • 地域包括ケアと口腔ケア, 渋谷 恭之, 監修, 口腔保健協会,   2017年08月
  • 歯科衛生士講座 口腔外科学 第二版, 渋谷 恭之, 分担執筆, 永末書店,   2017年01月
  • 言語聴覚士のための基礎知識 臨床歯科医学・口腔外科学 第二版, 渋谷 恭之, 分担執筆, 医学書院,   2016年12月
  • 「新・こんな患者さんが歯科に来たときは?全身疾患・口腔外科疾患に対する診療マニュアル」, 渋谷 恭之, 分担執筆, 第一歯科出版,   2014年09月
  • 「周術期口腔機能管理の基本がわかる本 -基礎知識から口腔管理の実際まで-」, 渋谷 恭之, 分担執筆, クインテッセンス出版,   2013年12月
  • 「歯科衛生士のための口腔外科学」, 渋谷 恭之, 分担執筆, 永末書店,   2011年10月
  • こんな患者さんが歯科に来たときは?全身疾患・口腔外科疾患に対する診療マニュアル, 渋谷 恭之, 分担執筆, 第一歯科出版,   2011年
  • 「医療従事者のための口腔外科学」, 渋谷 恭之, 分担執筆, 永末書店,   2006年11月
  • 「日常の口腔外科 はじめから」, 渋谷 恭之, 分担執筆, 永末書店,   2004年11月


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.