服部　浩二 (ハットリ　コウジ)

研究者情報

学位

• 工学博士（名古屋大学）
• 薬学修士（大阪大学）

科研費研究者番号

• 90775420

J-Global ID

• 201901007544349015

プロフィール

• 1985 大阪大学大学院薬学研究科修了
  
  1985 藤沢製薬工業株式会社入社
  
  1991-93 名古屋大学工学部留学（山本尚 教授）
  
  1994 名古屋大学工学博士
  
  1998-99 米国ハーバード大学留学（Stuart Schreiber教授）
  
  2007 アステラス製薬化学研究所 室長(senior director)
  
  2012 アステラス製薬化学研究所 主席研究員
  
  2014 東北大学医学部 特任教授
  
  2015 名古屋市立大学 特任教授

研究分野

• ライフサイエンス / 医療薬学

研究活動情報

論文

• Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta(3)-adrenergic receptor agonists with good oral bioavailability. Part I

  Masashi Imanishi; Yasuyo Tomishima; Shinji Itou; Hitoshi Hamashima; Yutaka Nakajima; Kenichi Washizuka; Minoru Sakurai; Shigeo Matsui; Emiko Imamura; Koji Ueshima; Takao Yamamoto; Nobuhiro Yamamoto; Hirofumi Ishikawa; Keiko Nakano; Naoko Unami; Kaori Hamada; Yasuhiro Matsumura; Fujiko Takamura; Kouji Hattori

  JOURNAL OF MEDICINAL CHEMISTRY 51 6 1925 - 1944 2008年03月 [査読有り]
  
• SYNTHETIC STUDIES ON SPIROKETAL NATURAL-PRODUCTS .2. AN ENANTIOSELECTIVE SYNTHESIS OF (R)-1,7-DIOXASPIRO[5.5]UNDECANE AND (S)-1,7-DIOXASPIRO[5.5]UNDECANE

  C IWATA; M FUJITA; T KUROKI; K HATTORI; S UCHIDA; T IMANISHI

  CHEMICAL & PHARMACEUTICAL BULLETIN 36 9 3257 - 3263 1988年09月 [査読有り]
  

MISC

• Addressing phototoxicity observed in a novel series of biaryl derivatives: Discovery of potent, selective and orally active phosphodiesterase 10A inhibitor ASP9436

  Wataru Hamaguchi; Naoyuki Masuda; Satoshi Miyamoto; Shigetoshi Kikuchi; Fumie Narazaki; Yasuhiro Shiina; Ryushi Seo; Yasushi Amano; Takuma Mihara; Hiroyuki Moriguchi; Kouji Hattori BIOORGANIC & MEDICINAL CHEMISTRY 23 (13) 3351 -3367 2015年07月
• Synthesis, SAR study, and biological evaluation of novel quinoline derivatives as phosphodiesterase 10A inhibitors with reduced CYP3A4 inhibition

  Wataru Hamaguchi; Naoyuki Masuda; Satoshi Miyamoto; Yasuhiro Shiina; Shigetoshi Kikuchi; Takuma Mihara; Hiroyuki Moriguchi; Hiroshi Fushiki; Yoshihiro Murakami; Yasushi Amano; Kazuya Honbou; Kouji Hattori BIOORGANIC & MEDICINAL CHEMISTRY 23 (2) 297 -313 2015年01月
• Discovery of novel selective human β 3 adrenergic receptor agonists as potential overactive bladder (OAB) therapies

  Masashi Imanishi; Kouji Hattori Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 69 (12) 1402 -1410 2011年12月
• Discovery of highly potent and selective biphenylacylsulfonamide-based β3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the β2-adrenergic receptor: Part 6

  Kouji Hattori; Masaya Orita; Susumu Toda; Masashi Imanishi; Shinji Itou; Yutaka Nakajima; Daisuke Tanabe; Kenichi Washizuka; Takanobu Araki; Minoru Sakurai; Shigeo Matsui; Emiko Imamura; Koji Ueshima; Takao Yamamoto; Nobuhiro Yamamoto; Hirofumi Ishikawa; Keiko Nakano; Naoko Unami; Kaori Hamada; Yasuhiro Matsumura; Fujiko Takamura Bioorganic and Medicinal Chemistry Letters 19 (16) 4679 -4683 2009年08月
• Discovery of highly potent and selective biphenylacylsulfonamide-based β3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: Part 5

  Kouji Hattori; Susumu Toda; Masashi Imanishi; Shinji Itou; Yutaka Nakajima; Kenichi Washizuka; Takanobu Araki; Hitoshi Hamashima; Yasuyo Tomishima; Minoru Sakurai; Shigeo Matsui; Emiko Imamura; Koji Ueshima; Takao Yamamoto; Nobuhiro Yamamoto; Hirofumi Ishikawa; Keiko Nakano; Naoko Unami; Kaori Hamada; Yasuhiro Matsumura; Fujiko Takamura Journal of Medicinal Chemistry 52 (9) 3063 -3072 2009年05月
• Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human β3-adrenergic receptor agonists: Part IV

  Yutaka Nakajima; Masashi Imanishi; Shinji Itou; Hitoshi Hamashima; Yasuyo Tomishima; Kenichi Washizuka; Minoru Sakurai; Shigeo Matsui; Emiko Imamura; Koji Ueshima; Takao Yamamoto; Nobuhiro Yamamoto; Hirofumi Ishikawa; Keiko Nakano; Naoko Unami; Kaori Hamada; Kouji Hattori Bioorganic and Medicinal Chemistry Letters 18 (18) 5037 -5040 2008年09月
• Discovery of a novel series of benzoic acid derivatives as potent and selective human β3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety

  Masashi Imanishi; Yutaka Nakajima; Yasuyo Tomishima; Hitoshi Hamashima; Kenichi Washizuka; Minora Sakurai; Shigeo Matsui; Emiko Imamura; Koji Ueshima; Takao Yamamoto; Nobuhiro Yamamoto; Hirofumi Ishikawa; Keiko Nakano; Naoko Unami; Kaori Hamada; Yasuhiro Matsumura; Fujiko Takamura; Kouji Hattori Journal of Medicinal Chemistry 51 (15) 4804 -4822 2008年08月
• Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human β3-adrenergic receptor agonists with good oral bioavailability. Part I

  Masashi Imanishi; Yasuyo Tomishima; Shinji Itou; Hitoshi Hamashima; Yutaka Nakajima; Kenichi Washizuka; Minoru Sakurai; Shigeo Matsui; Emiko Imamura; Koji Ueshima; Takao Yamamoto; Nobuhiro Yamamoto; Hirofumi Ishikawa; Keiko Nakano; Naoko Unami; Kaori Hamada; Yasuhiro Matsumura; Fujiko Takamura; Kouji Hattori Journal of Medicinal Chemistry 51 (13) 4002 -4020 2008年07月
• Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human β3 adrenergic receptor agonists with good oral bioavailability. Part II

  Masashi Imanishi; Shinji Itou; Kenichi Washizuka; Hitoshi Hamashima; Yutaka Nakajima; Takanobu Araki; Yasuyo Tomishima; Minoru Sakurai; Shigeo Matsui; Emiko Imamura; Koji Ueshima; Takao Yamamoto; Nobuhiro Yamamoto; Hirofumi Ishikawa; Keiko Nakano; Naoko Unami; Kaori Hamada; Yasuhiro Matsumura; Fujiko Takamura; Kouji Hattori Journal of Medicinal Chemistry 51 (13) 4002 -4020 2008年07月
• MEDI 268-Discovery of a novel series of biphenyl benzoic acid derivatives as potent, selective and orally bioavailable human beta 3 adrenergic receptor agonists with a long duration

  Masashi Imanishi; Yasuyo Tomishima; Shinji Itou; Hitoshi Hamashima; Yutaka Nakajima; Minoru Sakurai; Kenichi Washizuka; Shigeo Matsui; Emiko Imamura; Koji Ueshima; Takao Yamamoto; Kaori Hamada; Fujiko Takamura; Kouji Hattori ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 235 2008年04月
• Rational design of conformationally restricted quinazolinone inhibitors of poly(ADP-ribose)polymerase

  Kouji Hattori; Yoshiyuki Kido; Hirofurm Yamamoto; Junya Ishida; Akinori Iwashita; Kayoko Mihara BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 (20) 5577 -5581 2007年10月
• Metabolism investigation leading to novel drug design 2: Orally active prostacyclin mimetics. Part 5

  Fujiko Takamura; Akira Tanaka; Hisashi Takasugi; Kiyoshi Taniguchi; Mie Nishio; Jiro Seki; Kouji Hattori BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16 (17) 4475 -4478 2006年09月
• Replacing the cyclohexene-linker of FR181157 leading to novel IP receptor agonists: Orally active prostacyclin inimetics. Part 6

  Akira Tanaka; Kouji Hattori; Kiyoshi Taniguchi; Osamu Okitsu; Selichiro Tabuchi; Mie Nishio; Yasunori Nagakura; Noriaki Maeda; Hidetsugu Murai; Jiro Seki BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 16 (18) 4861 -4864 2006年09月
• Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling

  J Ishida; H Yamamoto; Y Kido; K Kamijo; K Murano; H Miyake; M Ohkubo; T Kinoshita; M Warizaya; A Iwashita; K Mihara; N Matsuoka; K Hattori BIOORGANIC & MEDICINAL CHEMISTRY 14 (5) 1378 -1390 2006年03月
• Novel and potent poly (ADP-ribose) polymerase-1 inhibitors, quinazolinone and quinoxaline derivatives, ameliorate dopaminergic neuronal damage in mice models of Parkinson's disease

  A Iwashita; K Mihara; S Yamazaki; S Matsuura; J Ishida; H Yamamoto; K Hattori; N Matsuoka; S Mutoh JOURNAL OF PHARMACOLOGICAL SCIENCES 100 195P -195P 2006年
• Discovery of novel prostacyclin mimetics with highly potent and selective IP receptor agonists

  Kouji Hattori Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry 64 (9) 923 -933 2006年
• 4-Phenyl-1,2,3,6-tetrahydropyridine, an excellent fragment to improve the potency of PARP-1 inhibitors

  J Ishida; K Hattori; H Yamamoto; A Iwashita; K Mihara; N Matsuoka BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (19) 4221 -4225 2005年10月
• Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: Orally active prostacyclin mimetics. Part 2

  K Hattori; O Okitsu; S Tabuchi; K Taniguchi; M Nishio; S Koyama; J Seki; K Sakane BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (13) 3279 -3283 2005年07月
• Metabolism investigation leading to novel drug design: Orally active prostacyclin mimetics. Part 4

  K Hattori; F Takamura; A Tanaka; H Takasugi; K Taniguchi; M Nishio; S Koyama; J Seki; K Sakane BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (13) 3284 -3287 2005年07月
• Discovery of diphenylcarbamate derivatives as highly potent and selective IP receptor agonists: Orally active prostacyclin mimetics. Part 3

  K Hattori; A Tanaka; O Okitsu; S Tabuchi; K Taniguchi; M Nishio; S Koyama; M Higaki; J Seki; K Sakane BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 (12) 3091 -3095 2005年06月
• Discovery of diphenyloxazole and Nδ-Z-ornithine derivatives as highly potent and selective human prostaglandin EP4 receptor antagonists

  Kouji Hattori; Akira Tanaka; Naoaki Fujii; Hisashi Takasugi; Yoshiyuki Tenda; Masayuki Tomita; Shoko Nakazato; Keiko Nakano; Yasuko Kato; Yutaka Kono; Hidetsugu Murai; Kazuo Sakane Journal of Medicinal Chemistry 48 (9) 3103 -3106 2005年05月
• Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors

  A Iwashita; K Hattori; H Yamamoto; J Ishida; Y Kido; K Kamijo; K Murano; H Miyake; T Kinoshita; M Warizaya; M Ohkubo; N Matsuoka; S Mutoh FEBS LETTERS 579 (6) 1389 -1393 2005年02月
• A new poly(ADP-ribose) polymerase inhibitor, FR261529 [2-(4-chlorophenyl)-5-quinoxalinecarboxamide], ameliorates methamphetamine-induced dopaminergic neurotoxicity in mice

  A Iwashita; K Mihara; S Yamazaki; S Matsuura; J Ishida; H Yamamoto; K Hattori; N Matsuoka; S Mutoh JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 310 (3) 1114 -1124 2004年09月
• A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia

  A Iwashita; N Tojo; S Matsuura; S Yamazaki; K Kamijo; J Ishida; H Yamamoto; K Hattori; N Matsuoka; S Mutoh JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 310 (2) 425 -436 2004年08月
• Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase

  K Hattori; Y Kido; H Yamamoto; J Ishida; K Kamijo; K Murano; M Ohkubo; T Kinoshita; A Iwashita; K Mihara; S Yamazaki; N Matsuoka; Y Teramura; H Miyake JOURNAL OF MEDICINAL CHEMISTRY 47 (17) 4151 -4154 2004年08月
• Neuroprotective effects of a novel poly(ADP-ribose) polymerase-1 inhibitor, 2-{3-[4-(4-chlorophenyl)-l-piperazinyl] propyl}-4(3H)-quinazolinone (FR255595), in an in Vitro model of cell death and in Mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of Parkinson's disease

  A Iwashita; S Yamazaki; K Mihara; K Hattori; H Yamamoto; J Ishida; N Matsuoka; S Mutoh JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 309 (3) 1067 -1078 2004年06月
• Inhibitor-induced structural change of the active site of human poly(ADP-ribose) polymerase

  T Kinoshita; Nakanishi, I; M Warizaya; A Iwashita; Y Kido; K Hattori; T Fujii FEBS LETTERS 556 (1-3) 43 -46 2004年01月
• A simple stereoselective synthesis and biological evaluation of FR181157: Orally active prostacyclin mimetic

  K Hattori; S Tabuchi; O Okitsu; K Taniguchi BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13 (24) 4277 -4279 2003年12月
• Synthesis and antibacterial evaluation of novel 2-[N-imidoylpyrrolidinyl] carbapenems

  K Hattori; A Yamada; S Kuroda; T Chiba; M Murata; K Sakane BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 12 (3) 383 -386 2002年02月
• A novel pyridazinone derivative as a nonprostanoid PGI(2) agonist

  K Tsubaki; K Taniguchi; S Tabuchi; O Okitsu; K Hattori; J Seki; K Sakane; H Tanaka BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10 (24) 2787 -2790 2000年12月
• Synthesis and antibacterial activity of novel 4-pyrrolidinylthio carbapenems .1. 2-alkoxymethyl derivatives

  H Azami; H Tsutsumi; K Matsuda; D Barrett; K Hattori; T Nakajima; S Kuroda; T Kamimura; M Murata BIOORGANIC & MEDICINAL CHEMISTRY 5 (11) 2069 -2087 1997年11月
• Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1'-substituted analogs

  A Yamada; K Hattori; S Kuroda; T Chiba; T Kamimura; K Sakane BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 6 (22) 2705 -2708 1996年11月
• Asymmetric synthesis of FR165914: A novel β 3 -adrenergic agonist with a benzocycloheptene structure

  Kouji Hattori; Masanobu Nagano; Takeshi Kato; Isao Nakanishi; Keisuke Imai; Takayoshi Kinoshita; Kazuo Sakane Bioorganic and Medicinal Chemistry Letters 5 (23) 2821 -2824 1995年12月
• A NEW CHIRAL BLA PROMOTER FOR ASYMMETRIC AZA-DIELS-ALDER AND ALDOL-TYPE REACTIONS OF IMINES

  K ISHIHARA; M MIYATA; K HATTORI; T TADA; H YAMAMOTO JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 116 (23) 10520 -10524 1994年11月
• HIGHLY SELECTIVE ENOLIZATION METHOD FOR HETEROATOM SUBSTITUTED ESTERS - ITS APPLICATION TO THE IRELAND ESTER ENOLATE CLAISEN REARRANGEMENT

  K HATTORI; H YAMAMOTO TETRAHEDRON 50 (10) 3099 -3112 1994年03月
• Practical preparation of α-hydroxy-β-amino ester units; Stereoselective synthesis of taxol side chain and norstatine

  Kouji Hattori; Hisashi Yamamoto Tetrahedron 50 (9) 2785 -2792 1994年02月
• A Novel Stereocontrolled Synthesis of 3-(1′-Hydroxyethyl)-2-Azetidinone

  Kouji Hattori; Hisashi Yamamoto Synlett 1993 (3) 239 -240 1993年03月
• Highly Selective and Operationally Simple Synthesis of Enantiomerically Pure β-Amino Esters via Double Stereodifferentiation

  Kouji Hattori; Mayumi Miyata; Hisashi Yamamoto Journal of the American Chemical Society 115 (3) 1151 -1152 1993年02月
• ASYMMETRIC AZA-DIELS-ALDER REACTION CATALYZED BY BORON REAGENT - EFFECT OF BIPHENOL AND BINAPHTHOL LIGAND

  K HATTORI; H YAMAMOTO SYNLETT 1993 (2) 129 -130 1993年02月
• ASYMMETRIC AZA-DIELS-ALDER REACTION - ENANTIOSELECTIVE AND DIASTEREOSELECTIVE REACTION OF IMINE MEDIATED BY CHIRAL LEWIS ACID

  K HATTORI; H YAMAMOTO TETRAHEDRON 49 (9) 1749 -1760 1993年02月
• Synthetic Studies on Spiroketal Natural Products. IV.1) A Stereoselective Synthesis of (3A,5S,6R,9R,Rs)-3-Benzyloxymethyl-9-hydroxymethyl-5-(p-tolyl)sulfinyl-1,7-dioxaspiro[5.5] unDecane, a Key Intermediate for Talaromycins2)

  Chuzo Iwata; Naoyoshi Maezaki; Kohji Hattori; Masahiro Fujita; Yasunori Moritani; Yoshiji Takemoto; Tetsuaki Tanaka; Takeshi Imanishi Chemical and Pharmaceutical Bulletin 41 (2) 339 -345 1993年
• Synthetic Studies on Spiroketal Natural Products. V. Total Synthesis of (+)-Talaromycin A and (—)-Talaromycin B

  Chuzo Iwata; Naoyoshi Maezaki; Kohji Hattori; Masahiro Fujita; Yasunori Moritani; Yoshiji Takemoto; Tetsuaki Tanaka; Takeshi Imanishi Chemical and Pharmaceutical Bulletin 41 (5) 946 -950 1993年
• Highly Selective Generation and Application of (E)- and (Z)-Silyl Ketene Acetals from α-Hydroxy Esters

  Kouji Hattori; Hisashi Yamamoto Journal of Organic Chemistry 58 (20) 5301 -5303 1993年
• Novel asymmetric synthesis of β-lactams with 3-(1′-hydroxyethyl) substituents: boron reagent mediated aldol reaction of chiral imines and silyl ketene acetals derived from 3-hydroxybutyrate

  Kouji Hattori; Hisashi Yamamoto Bioorganic and Medicinal Chemistry Letters 3 (11) 2337 -2342 1993年
• ASYMMETRIC AZA-DIELS-ALDER REACTION MEDIATED BY CHIRAL BORON REAGENT

  K HATTORI; H YAMAMOTO JOURNAL OF ORGANIC CHEMISTRY 57 (12) 3264 -3265 1992年06月
• Synthetic Studies on Spiroketal Natural Products. I. A Stereoselective Synthesis of (2R*,5R*)- and (2R*,5S*)-2-Methyl-l,6-dioxaspiro[4.5]decane1)

  Chuzo Iwata; Kohji Hattori; Toshio Kuroki; Shuji Uchida; Takeshi Imanishi Chemical and Pharmaceutical Bulletin 36 (8) 2909 -2917 1988年
• A TOTAL SYNTHESIS OF (+)-TALAROMYCIN-A

  C IWATA; M FUJITA; Y MORITANI; K HATTORI; T IMANISHI JOURNAL OF PHARMACEUTICAL SCIENCES 76 (11) S234 -S234 1987年11月
• ASYMMETRIC FUNCTIONALIZATION AT A PROCHIRAL CARBON CENTER BY THE AID OF SULFINYL CHIRALITY - A SELECTIVE FORMATION OF 6-SUBSTITUTED (3R,SS) AND (3S,SS)-3-HYDROXYMETHYL-3,4-DIHYDRO-5-(PARA-TOLYL)SULFINYL-2H-PYRANS

  C IWATA; M FUJITA; Y MORITANI; K SUGIYAMA; K HATTORI; T IMANISHI TETRAHEDRON LETTERS 28 (27) 3131 -3134 1987年
• ASYMMETRIC INDUCTION BY SULFINYL CHIRALITY - A TOTAL SYNTHESIS OF (+)-TALAROMYCIN A AND (-)-TALAROMYCIN-B

  C IWATA; M FUJITA; Y MORITANI; K HATTORI; T IMANISHI TETRAHEDRON LETTERS 28 (27) 3135 -3138 1987年
• STEREOSELECTIVE SYNTHETIC STUDIES ON BIOLOGICALLY-ACTIVE NATURAL SPIROKETALS

  C IWATA; K HATTORI; M FUJITA; S UCHIDA; T IMANISHI HETEROCYCLES 23 (1) 229 -229 1985年
• INTRAMOLECULAR MICHAEL ADDITION-REACTION TO CHIRAL VINYLIC SULFOXIDES - AN ENANTIOSELECTIVE SYNTHESIS OF (R)-1,7-DIOXASPIRO[5.5]UNDECANE AND (S)-1,7-DIOXASPIRO[5.5]UNDECANE

  C IWATA; M FUJITA; K HATTORI; S UCHIDA; T IMANISHI TETRAHEDRON LETTERS 26 (18) 2221 -2224 1985年
• A new and facile route to spiro-ketal skeleton via highly stereoselective CO bond formation by intramolecular Michael addition to δ,β-unsaturated sulfoxides

  Chuzo Iwata; Kohji Hattori; Shuji Uchida; Takeshi Imanishi Tetrahedron Letters 25 (28) 2995 -2998 1984年

その他のリンク

researchmap

https://researchmap.jp/koujih