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鈴木 貞夫スズキ サダオ

所属部署医学研究科公衆衛生学分野
職名教授
メールアドレス
ホームページURLhttps://www.nagoya-cu.ac.jp/med/labo/kouei/index.html
生年月日
Last Updated :2020/06/02

研究者基本情報

基本情報

    ORCID ID:0000-0001-5988-4849

学歴

  • 2000年09月 - 2001年06月, ハーバード大学公衆衛生学部, 疫学学科
  • 1986年04月 - 1990年03月, 名古屋大学大学院医学研究科, 博士課程 修了
  • 1980年04月 - 1986年03月, 名古屋大学, 医学部

所属学協会

  • 日本疫学会
  • 日本癌学会
  • 日本公衆衛生学会
  • 東海公衆衛生学会
  • 日本がん疫学・分子疫学研究会
  • 国際疫学会

経歴

  •   2010年04月 - 現在, 名古屋市立大学大学院医学研究科, 公衆衛生学分野, 教授
  •   2003年01月 - 2010年03月, 名古屋市立大学大学院医学研究科, 公衆衛生学分野, 講師
  •   1996年09月 - 2002年12月, Harvard School of Public Health, Dept. of Nutrition, Visiting Scientist
  •   1994年04月 - 1996年08月, 愛知医科大学医学部, 公衆衛生学, 講師
  •   1990年04月 - 1994年03月, 名古屋大学大学院医学系研究科, 予防医学教室, 助手

研究活動情報

研究分野

  • ライフサイエンス, 医療管理学、医療系社会学, 疫学

研究キーワード

    運動, 肥満, メタボリックシンドローム, 検査比較

論文

  • Author Correction: Characterizing rare and low-frequency height-associated variants in the Japanese population., Masato Akiyama, Kazuyoshi Ishigaki, Saori Sakaue, Yukihide Momozawa, Momoko Horikoshi, Makoto Hirata, Koichi Matsuda, Shiro Ikegawa, Atsushi Takahashi, Masahiro Kanai, Sadao Suzuki, Daisuke Matsui, Mariko Naito, Taiki Yamaji, Motoki Iwasaki, Norie Sawada, Kozo Tanno, Makoto Sasaki, Atsushi Hozawa, Naoko Minegishi, Kenji Wakai, Shoichiro Tsugane, Atsushi Shimizu, Masayuki Yamamoto, Yukinori Okada, Yoshinori Murakami, Michiaki Kubo, Yoichiro Kamatani, Nature communications, 11, (1) 1350 - 1350,   2020年03月09日, 査読有り, An amendment to this paper has been published and can be accessed via a link at the top of the paper.
  • Effects of obesity, metabolic syndrome, and non-alcoholic or alcoholic elevated liver enzymes on incidence of diabetes following lifestyle intervention: A subanalysis of the J-DOIT1, Sakane N, Kotani K, Suganuma A, Takahashi K, Sato J, Suzuki S, Izumi K, Kato M, Noda M, Nirengi S, Kuzuya H, Journal of Occupational Health, 62, (1) ,   2020年01月, 査読有り
  • Association between second-hand smoke exposure and depressive symptoms among Japanese adults: a cross-sectional study., Noguchi T, Nakagawa-Senda H, Tamai Y, Nishiyama T, Watanabe M, Hosono A, Shibata K, Ichikawa M, Wakabayashi R, Nagaya K, Ema K, Okamoto N, Tsujimura S, Fujita H, Kamiya M, Kondo F, Yamada T, Suzuki S, Journal of epidemiology,   2019年12月, 査読有り
  • Epidemiological characteristics of rheumatoid arthritis in Japan: Prevalence estimates using a nationwide population-based questionnaire survey., Masayo Kojima, Takeo Nakayama, Kiichiro Tsutani, Ataru Igarashi, Toshihisa Kojima, Sadao Suzuki, Nobuyuki Miyasaka, Hisashi Yamanaka, Modern rheumatology, 1 - 7,   2019年11月14日, 査読有り, Objectives: To elucidate the epidemiological characteristics of patients with rheumatoid arthritis (RA) in Japan using data from the Comprehensive Survey of Living Conditions, a nationwide questionnaire survey conducted in 2016.Methods: In total, 222,365 men and 245,251 women aged ≥16 years were included in the study. RA patients were defined as those who reported 'currently receiving treatment for RA at hospitals, clinics, or a facility for Japanese traditional massage, acupuncture, moxibustion, or judo-orthopedics.' The number of RA patients was estimated from the age-specific prevalence and total Japanese population in 2016. Further, the prevalence of individuals experiencing difficulties in activities of daily living due to health problems and those with mental distress as evaluated by K6 Scale was examined.Results: The estimated number and prevalence of RA in Japan with 95% confidence interval was 822 (768-880) thousand and 0.75% (0.70-0.80%). The population peaked in the late 60s, and the prevalence continued increasing until the early 80s, regardless of sex. Compared with non-RA participants, RA patients were more likely to experience difficulties in activities and to be distressed.Conclusion: High prevalence of RA in older age and mental and physical burden among RA patients were confirmed.
  • Cohort profile: Aichi regional sub-cohort of the Japan Environment and Children's Study (JECS-A)., Takeshi Ebara, Yasuyuki Yamada, Naoto Shoji, Yuki Ito, Atsuko Nakagawa, Taishi Miyachi, Yasuhiko Ozaki, Toyonori Omori, Sadao Suzuki, Masayo Kojima, Jun Ueyama, Motohiro Tomizawa, Sayaka Kato, Tomoko Oguri, Taro Matsuki, Hirotaka Sato, Naoko Oya, Mayumi Sugiura-Ogasawara, Shinji Saitoh, Michihiro Kamijima, BMJ open, 9, (11) ,   2019年11月12日, 査読有り, PURPOSE: Effects of fetal, perinatal and childhood environment on the health of children at birth and during later life have become a topic of concern. The Aichi regional sub-cohort of the Japan Environment and Children's Study (JECS-A) is an ongoing birth cohort of pregnant women and their children which has been used to provide unique data, as adjunct studies of JECS, on multifaceted potential factors affecting children's health. PARTICIPANTS: The JECS-A is part of the JECS which follows a total of 100 000 pairs of children and their mothers (fathers' participation is optional) across 15 regions in Japan. In JECS-A, of the 8134 pregnant women living in Ichinomiya City and Nagoya City, Japan, a total of 5721 pregnant women and their 5554 children were included. Sociodemographic and psychological data as well as biological specimens were collected from the pregnant women and their spouses (if available) in the cohort during their pregnancy. Information on children included in the JECS-A was collected from their mothers and includes demographic, behavioural, childcare, psychological and psychiatric data. Urine extracted from disposable diapers and anthropometric data were also obtained from the children. FINDINGS TO DATE: A similar distribution trend for age at delivery was confirmed between the pregnant women enrolled in the JECS-A and the national statistics of the relevant areas. However, differences in education level and household income were observed. A total of 5502 children remained in the cohort at 18 months after delivery. Compared with the national statistics, the basic demographics of the children in the cohort represented the population in the study areas. FUTURE PLANS: The enrolled children in the JECS-A will be followed until the age of 13 years. The studies that come from JECS-A will complement JECS and bring novel results with a high level of generalisability.
  • The interaction between ABCA1 polymorphism and physical activity on the HDL-cholesterol levels in a Japanese population, Nishida Y, Hachiya T, Hara M, Shimanoe C, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Tsukamoto M, Kadomatsu Y, Oze I, Koyanagi YN, Kuriyama N, Koyama T, Ibusuki R, Takezaki T, Ikezaki H, Furusyo N, Takashima N, Kadota A, Uemura H, Katsuura-Kamano S, Suzuki S, Nakagawa-Senda H, Kuriki K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K, J Lipid Res,   2019年11月, 査読有り
  • Community social capital and the onset of functional disability among older adults in Japan: a multilevel longitudinal study using Japan Gerontological Evaluation Study (JAGES) data., Taiji Noguchi, Katsunori Kondo, Masashige Saito, Hiroko Nakagawa-Senda, Sadao Suzuki, BMJ open, 9, (10) ,   2019年10月08日, 査読有り, OBJECTIVE: The present study examined the association between community social capital and the onset of functional disability among older Japanese people by using validated indicators of social capital and a prospective multilevel design. DESIGN: Prospective cohort study SETTING: We used data from the Japan Gerontological Evaluation Study, established from August 2010 to January 2012 in 323 districts. PARTICIPANTS: The target population was restricted to non-institutionalised people aged 65 years or older who were independent in activities of daily living. Participants included 73 021 people (34 051 men and 38 970 women) who were followed up over a 3-year period. PRIMARY OUTCOME MEASURE: The primary outcome measure was the onset of functional disability, defined as a new registration in public long-term care insurance system records with a care-needs level of two or above, analysed with multilevel Cox proportional hazards regression models by community social capital (civic participation, social cohesion and reciprocity). RESULTS: The mean age of participants was 73.3 years (SD=6.0) for men and 73.8 years (SD=6.2) for women. During the study period, the onset of functional disability occurred in 1465 (4.3%) men and 1519 (3.9%) women. Of three community social capital variables, social cohesion significantly reduced the risk of onset of functional disability (HR 0.910; 95% CI 0.830 to 0.998) among men, after adjusting for individual social and behavioural variables. There was no significant effect among women. CONCLUSIONS: Living in a community with rich social cohesion is associated with a lower incidence of onset of functional disability among older Japanese men.
  • Characterizing rare and low-frequency height-associated variants in the Japanese population., Akiyama M, Ishigaki K, Sakaue S, Momozawa Y, Horikoshi M, Hirata M, Matsuda K, Ikegawa S, Takahashi A, Kanai M, Suzuki S, Matsui D, Naito M, Yamaji T, Iwasaki M, Sawada N, Tanno K, Sasaki M, Hozawa A, Minegishi N, Wakai K, Tsugane S, Shimizu A, Yamamoto M, Okada Y, Murakami Y, Kubo M, Kamatani Y, Nature communications, 10, (1) ,   2019年09月, 査読有り
  • Letter to the editor: Safety concerns with human pappilloma virus immunization in Japan: Analysis and evaluation of Nagoya City's surveillance data for adverse events, Suzuki S, Jpn J Nur Sci/Early View,   2019年09月, 査読有り
  • Combined effect of weight gain within normal weight range and parental hypertension on the prevalence of hypertension; from the J-MICC Study, Okada R, Kadomatsu Y, Tsukamoto M, Sasakabe T, Kawai S, Tamura T, Hishida A, Ikezaki H, Furusho N, Tanaka K, Hara M, Suzuki S, Watanabe M, Takezaki T, Nishimoto D, Matsui D, Watanabe I, Kuriki K, Takashima N, Nakamura Y, Katsuura-Kamano S, Arisawa K, Mikami H, Nakamura Y, Oze I, Koyanagi YN, Natio M, Wakai K, Japan Multi-institutional collaborative Cohort, Study Group, J Hum Hypertens,   2019年09月, 査読有り
  • 地域住民における出生体重と生活習慣病との関連, 神谷真有美, 神谷真有美, 細野晃弘, 細野晃弘, 玉井裕也, 玉井裕也, 渡邉美貴, 柴田清, 柴田清, 辻村尚子, 藤田ひとみ, 岡本尚子, 岡本尚子, 近藤文, 若林諒三, 山田珠樹, 鈴木貞夫, 東海公衆衛生雑誌, 7, (1) ,   2019年07月, 査読有り, 出生体重と,その後の成人期以降に生じ得る生活習慣病との関連について検討した。結果として出生体重を「普通」と回答した者に比べ,男性では,出生体重「非常に大きかった・大きかった」回答群で,インスリン抵抗性高値のオッズ比が0.59(95%CI:0.44-0.79),肥満のオッズ比が1.32(95%CI:1.05-1.68)と有意であった。また,出生体重「小さかった」回答群で,拡張期血圧高値のオッズ比が1.33(95%CI:1.01-1.76),ヘモグロビンA1c高値のオッズ比が1.54(95%CI:1.15-2.06)であった。女性では,出生体重「非常に大きかった・大きかった」回答群で,肥満のオッズ比が1.39(95%CI:1.02-1.89),出生体重「小さかった」回答群で中性脂肪高値のオッズ比が1.49(95%CI:1.01-2.20), 出生体重「未熟児」回答群で,収縮期血圧高値のオッズ比が1.78(95%CI:1.11-2.87),肥満のオッズ比が2.24(95%CI:1.44-3.50)であった。
  • Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population., Takeshi Nishiyama, Masahiro Nakatochi, Atsushi Goto, Motoki Iwasaki, Tsuyoshi Hachiya, Yoichi Sutoh, Atsushi Shimizu, Chaochen Wang, Hideo Tanaka, Miki Watanabe, Akihiro Hosono, Yuya Tamai, Tamaki Yamada, Taiki Yamaji, Norie Sawada, Kentaro Fukumoto, Kotaro Otsuka, Kozo Tanno, Hiroaki Tomita, Kaname Kojima, Masao Nagasaki, Atsushi Hozawa, Asahi Hishida, Tae Sasakabe, Yuichiro Nishida, Megumi Hara, Hidemi Ito, Isao Oze, Yohko Nakamura, Haruo Mikami, Rie Ibusuki, Toshiro Takezaki, Teruhide Koyama, Nagato Kuriyama, Kaori Endoh, Kiyonori Kuriki, Tanvir C Turin, Takashima Naoyuki, Sakurako Katsuura-Kamano, Hirokazu Uemura, Rieko Okada, Sayo Kawai, Mariko Naito, Yukihide Momozawa, Michiaki Kubo, Makoto Sasaki, Masayuki Yamamoto, Shoichiro Tsugane, Kenji Wakai, Sadao Suzuki, Sleep, 42, (6) ,   2019年06月11日, 査読有り, Usual sleep duration has substantial heritability and is associated with various physical and psychiatric conditions as well as mortality. However, for its genetic locus, only PAX8 and VRK2 have been replicated in previous genome-wide association studies (GWAS). We conducted a GWAS meta-analysis of self-reported usual sleep duration using three population-based cohorts totaling 31 230 Japanese individuals. A genome-wide significant locus was identified at 12q24 (p-value < 5.0 × 10-8). Subsequently, a functional variant in the ALDH2 locus, rs671, was replicated in an independent sample of 5140 Japanese individuals (p-value = 0.004). The association signal, however, disappeared after adjusting for alcohol consumption, indicating the possibility that the rs671 genotype modifies sleep duration via alcohol consumption. This hypothesis explained a modest genetic correlation observed between sleep duration and alcohol consumption (rG = 0.23). A Mendelian randomization analysis using rs671 and other variants as instrumental variables confirmed this by showing a causal effect of alcohol consumption, but not of coffee consumption on sleep duration. Another genome-wide significant locus was identified at 5q33 after adjusting for drinking frequency. However, this locus was not replicated, nor was the PAX8 and VRK2. Our study has confirmed that a functional ALDH2 variant, rs671, most strongly influences on usual sleep duration possibly via alcohol consumption in the Japanese population, and presumably in East Asian populations. This highlights the importance of considering the involvement of alcohol consumption in future GWAS of usual sleep duration, even in non-East Asian populations, where rs671 is monomorphic.
  • Handling missing data in an FFQ: Multiple imputation and nutrient intake estimates, Mari Ichikawa, Akihiro Hosono, Yuya Tamai, Miki Watanabe, Kiyoshi Shibata, Shoko Tsujimura, Kyoko Oka, Hitomi Fujita, Naoko Okamoto, Mayumi Kamiya, Fumi Kondo, Ryozo Wakabayashi, Taiji Noguchi, Tatsuya Isomura, Nahomi Imaeda, Chiho Goto, Tamaki Yamada, Sadao Suzuki, Public Health Nutrition, 22, 1351 - 1360,   2019年06月01日, © 2019 The Authors. Objective: We aimed to examine missing data in FFQ and to assess the effects on estimating dietary intake by comparing between multiple imputation and zero imputation. Design: We used data from the Okazaki Japan Multi-Institutional Collaborative Cohort (J-MICC) study. A self-administered questionnaire including an FFQ was implemented at baseline (FFQ1) and 5-year follow-up (FFQ2). Missing values in FFQ2 were replaced by corresponding FFQ1 values, multiple imputation and zero imputation. Setting: A methodological sub-study of the Okazaki J-MICC study. Participants: Of a total of 7585 men and women aged 35-79 years at baseline, we analysed data for 5120 participants who answered all items in FFQ1 and at least 50% of items in FFQ2. Results: Among 5120 participants, the proportion of missing data was 3.7%. The increasing number of missing food items in FFQ2 varied with personal characteristics. Missing food items not eaten often in FFQ2 were likely to represent zero intake in FFQ1. Most food items showed that the observed proportion of zero intake was likely to be similar to the probability that the missing value is zero intake. Compared with FFQ1 values, multiple imputation had smaller differences of total energy and nutrient estimates, except for alcohol, than zero imputation. Conclusions: Our results indicate that missing values due to zero intake, namely missing not at random, in FFQ can be predicted reasonably well from observed data. Multiple imputation performed better than zero imputation for most nutrients and may be applied to FFQ data when missing is low.
  • Genome-wide association meta-analysis and Mendelian randomization analysis confirm the influence of ALDH2 on sleep durationin the Japanese population., Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S, Sleep, 42, (6) ,   2019年06月, 査読有り
  • Independent relationships of daily life activity and leisure-time exercise with metabolic syndrome and its traits in the general Japanese population, Uemura H, Katsuura-Kamano S, Iwasaki Y, Arisawa K, Hishida A, Okada R, Tamura T, Kubo Y, Ito H, Oze I, Shinanoe C, Nishida Y, Nakamura Y, Takashima N, Suzuki S, Nakagawa-Senda H, Nishimoto D, Takezaki T, Mikami H, Nakamura Y, Furusyo N, Ikazaki H, Ozaki E, Koyama T, Kuriki K, Endoh K, Naito M, Wakai K, Japan Multi-institutional Collaborative Cohort, J-MIC, Study Group, Endocrine, 64, (3) 552 - 563,   2019年06月, 査読有り
  • Prevention of Metabolic Syndrome by Telephone-Delivered Lifestyle Intervention in a Real-World Setting: Sub-Analysis of a Cluster-Randomized Trial., Sakane N, Kotani K, Suganuma A, Takahashi K, Sato J, Suzuki S, Izumi K, Kato M, Noda M, Nirengi S, Kuzuya H, Metabolic Syndrome and Related Disorders.,   2019年05月, 査読有り
  • Associations of Nutrient Patterns with the Prevalence of Metabolic Syndrome: Results from the Baseline Data of the Japan Multi-Institutional Collaborative Cohort Study., Yuki Iwasaki, Kokichi Arisawa, Sakurako Katsuura-Kamano, Hirokazu Uemura, Mineko Tsukamoto, Yuka Kadomatsu, Rieko Okada, Asahi Hishida, Keitaro Tanaka, Megumi Hara, Toshiro Takezaki, Keiichi Shimatani, Etsuko Ozaki, Teruhide Koyama, Sadao Suzuki, Hiroko Nakagawa-Senda, Kiyonori Kuriki, Naoko Miyagawa, Aya Kadota, Hiroaki Ikezaki, Norihiro Furusyo, Isao Oze, Hidemi Ito, Haruo Mikami, Yohko Nakamura, Kenji Wakai, Nutrients, 11, (5) ,   2019年04月30日, 査読有り, : The association between nutrient patterns and metabolic syndrome (MetS) has not been examined in a Japanese population. A cross-sectional study was performed on 30,108 participants (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study. Dietary intake was assessed using a 46-item food frequency questionnaire. MetS was diagnosed according to the Joint Interim Statement Criteria of 2009, using body mass index instead of waist circumference. Factor analysis was applied to energy-adjusted intake of 21 nutrients, and three nutrient patterns were extracted: Factor 1 (fiber, potassium and vitamins pattern); Factor 2 (fats and fat-soluble vitamins pattern); and Factor 3 (saturated fatty acids, calcium and vitamin B2 pattern). In multiple logistic regression analysis adjusted for sex, age, and other potential confounders, Factor 1 scores were associated with a significantly reduced odds ratio (OR) of MetS and all five components. Factor 2 scores were associated with significantly increased prevalence of MetS, obesity, and high blood pressure. Factor 3 scores were significantly associated with lower OR of MetS, high blood pressure, high serum triglycerides and low HDL cholesterol levels. Analysis of nutrient patterns may be useful to assess the overall quality of diet and its association with MetS.
  • Association of genetic risk score and chronic kidney disease in a Japanese population, Fujii R, Hishida A, Nakatochi M, Furusyo N, Murata M, Tanaka K, Shimanoe C, Suzuki S, Watanabe M, Kuriyama N, Koyama T, Takezaki T, Shimoshikiryo I, Arisawa K, Katsuura-Kamano S, Takashima N, Turin TC, Kuriki K, Endoh K, Mikami H, Nakamura Y, Oze I, Ito H, Kubo M, Momozawa Y, Kondo T, Naito M, Wakai K, Nephrology, 24, (6) 670 - 673,   2019年04月, 査読有り
  • 若年期の身体活動量と壮年期以降のインスリン抵抗性の関係:横断研究, 藤田 ひとみ, 市川 麻理, 山田 珠樹, 鈴木 貞夫, 細野 晃弘, 柴田 清, 辻村 尚子, 岡 京子, 岡本 尚子, 神谷 真有美, 近藤 文, 若林 諒三, 運動疫学研究, 21, (1) 47 - 55,   2019年03月, 査読有り, 目的:身体活動は糖代謝に影響を及ぼすことが知られており,生活習慣病の予防と密接な関係をもつ。我々は過去の身体活動について若年期の身体活動量に着目し,壮年期以降の糖代謝との関係について調査した。方法:対象者は,40歳から79歳までの愛知県岡崎市の住民で,2007年4月から2011年8月までの間に岡崎市医師会公衆衛生センターで健康診断を受け,研究への参加に同意が得られた者とした。過去の身体活動量とインスリン抵抗性との関連を検討するために,質問紙から得られた年齢,BMI,飲酒および喫煙習慣,現在の運動習慣を調整した多変量線形回帰分析を行った。結果<:最終的に男女合計2,378名から得られたデータを分析した。インスリン抵抗性を目的変数とした多変量線形回帰分析の結果,インスリン抵抗性と年齢,BMIには有意に正の関連を認め,飲酒習慣,現在の運動習慣,若年期の身体活動には有意に負の関連を認めた。20代の「やりすぎ」群を除いては,インスリン抵抗性の正常範囲内の数値であった。結論</:若年期に定期的な身体活動がある場合,壮年期以降のインスリン抵抗性をもつ割合は低く,身体活動量が多くなるにつれてインスリン抵抗性が低くなる傾向がみられた。
  • Genome-wide meta-analysis identifies multiple novel loci associated with serum uric acid levels in Japanese individuals, Nishiyama T, Nakatochi M, Goto A, Iwasaki M, Hachiya T, Sutoh Y, Shimizu A, Wang C, Tanaka H, Watanabe M, Hosono A, Tamai Y, Yamada T, Yamaji T, Sawada N, Fukumoto K, Otsuka K, Tanno K, Tomita H, Kojima K, Nagasaki M, Hozawa A, Hishida A, Sasakabe T, Nishida Y, Hara M, Ito H, Oze I, Nakamura Y, Mikami H, Ibusuki R, Takezaki T, Koyama T, Kuriyama N, Endoh K, Kuriki K, Turin TC, Naoyuki T, Katsuura-Kamano S, Uemura H, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Sasaki M, Yamamoto M, Tsugane S, Wakai K, Suzuki S, Sleep, 42, (6) ,   2019年02月, 査読有り
  • GWAS analysis reveals a significant contribution of PSCA to the risk of Helicobacter pylori-induced gastric atrophy, Hishida A, Ugai T, Fujii R, Nakatochi M, Wu MC, Ito H, Oze I, Masahiro T, Yasumasa N, Nishiyama T, Nakagawa-Senda H, Suzuki S, Koyama T, Matusui D, Watanabe Y, Kawaguchi T, Matsuda F, Momozawa Y, Kubo M, Naito M, Matsuo K, Wakai K, Carcinogenesis,   2019年02月, 査読有り
  • The association of PSCA gene and H. pylori-related gastric atrophy risk detected by GWAS and SKAT, Hishida Asahi, Fujii Ryosuke, Nakatochi Masahiro, Kawai Sayo, Ito Hidemi, Matsuo Keitaro, Watanabe Miki, Suzuki Sadao, Kuriyama Nagato, Naito Mariko, Wakai Kenji, CANCER SCIENCE, 109,   2018年12月
  • Association of exposure level to passive smoking with hypertension among lifetime nonsmokers in Japan: a cross-sectional study, Tamura T, Kadomatsu Y, Tsukamoto M, Okada R, Sasakabe T, Kawai S, Hishida A, Hara M, Tanaka K, Shimoshikiryo I, Takazaki T, Watanabe I, Matsui D, Nishiyama T, Suzuki S, Endoh K, Kuriki K, Kita Y, Katsuura-Kamano S, Arisawa K, Ikezaki H, Furusyo N, Koyanagi YN, Oze I, Nakamura Y, Mikami H, Naito M, Wakai K, Japan Multi-Institutional Collaborative Cohort, J-MICC) Study, Medicine, 97, (48) ,   2018年11月, 査読有り
  • Physical activity earlier in life is inversely associated with insulin resistance among adults in Japan, Fujita H, Hosono A, Shibata K, Tsujimura S, Oka K, Okamoto N, Kamiya M, Kondo F, Wakabayashi R, Ichikawa M, Yamada T, Suzuki S, J Epidemiol, 29, (2) 57 - 60,   2018年09月, 査読有り
  • Genome-wide association study of renal function traits: Results from the J-MICC Study, Hishida A, Nakatochi M, Akiyama M, Kamatani Y, Nishiyama T, Ito H, Oze I, Nishida Y, Hara M, Takashima N, Tanvir Turin, Watanabe M, Suzuki S, Ibusuki R, Shimoshikiryo I, Nakamura Y, Mikami H, Ikezaki H, Furusyo N, Kuriki K, Endoh K, Koyama T, Matsui D, Uemura H, Arisawa K, Sasakabe T, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Wakai K, Am J Nephrol, 47, (5) 304 - 316,   2018年05月, 査読有り
  • A genome-wide association study of coping behaviros suggests FBXO45 is associated with emotional expression, Shimanoe C, Hachiya T, Hara M, Nishida Y, Tanaka K, Sutoh Y, Shimizu A, Hishida A, Kawai S, Okada R, Tamura T, Matsuo K, Ito H, Ozaki E, Matsui D, Ibusuki R, Shimoshikiryo I, Takashima N, Kadota A, Arisawa K, Uemura H, Suzuki S, Watanabe M, Kuriki K, Endoh K, Mikami H, Nakamura Y, Momozawa Y, Kubo M, Nakatochi M, Naito M, Wakai K, Genes Brain Behav, e12481,   2018年04月, 査読有り
  • Modification of the associations of alcohol intake with serum low-density lipoprotein chorlesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men, Sasakabe T, Wakai K, Kawai S, Hishida A, Naito M, Suzuki S, Nindita Y, Arisawa K, Kita Y, Hara M, Kuriyama N, Hirata A, Mikami H, Oze I, Kubo M, Tanaka H, Hamajima N, J Epidemiol, 28, (4) 185 - 193,   2018年04月, 査読有り, 招待有り
  • Modification of the associations of alcohol intake with serum low-density lipoprotein chorlesterol and triglycerides by ALDH2 and ADH1B polymorphisms in Japanese men, Sasakabe T, Wakai K, Kawai S, Hishida A, Naito M, Suzuki S, Nindita Y, Arisawa K, Kita Y, Hara M, Kuriyama N, Hirata A, Mikami H, Oze I, Kubo M, Tanaka H, Hamajima N, J Epidemiol, 28, 183 - 193,   2018年, 査読有り
  • Association of genetic variants of PD1 with recurrent pregnancy loss, Hayashi Y, Nishiyama T, Nakatochi M, Suzuki S, Takahashi S, Sugiura-Ogasawara M, Reprod Med Biol, 17, (2) 195 - 202,   2018年, 査読有り
  • Genome-wide association study of leisure-time exercise behavior in Japanese adults, Hara M, Hachiya T, Sutoh Y, Matsuo K, Nishida Y, Shimanoe C, Tanaka K, Shimizu A, Ohnaka K, Kawaguchi T, Oze I, Matsuda F, Ito H, Kawai S, Hishida A, Okada R, Sasakabe T, Hirata A, Ibusuki R, Nindita, Furusyo N, Ikezaki H, Kuriyama N, Ozaki E, Mikami H, Nakamura Y, Suzuki S, Hosono A, Katsuura-Kamano S, Arisawa K, Kuriki K, Endoh K, Takashima N, Kadota A, Nakatochi M, Momozawa Y, Kubo M, Naito M, Wakai K, Med Sci Sports Exerc, [Epub],   2018年, 査読有り
  • A genome-wide association study in the Japanese population identifies the 12q24 locus for habitual coffee consumption: The J-MICC Study, Nakagawa-Senda, H. Hachiya, T. Shimizu, A. Hosono, S. Oze, I. Watanabe, M. Matsuo, K. Ito, H. Hara, M. Nishida, Y. Endoh, K. Kuriki, K. Katsuura-Kamano, S. Arisawa, K. Nindita, Y. Ibusuki, R. Suzuki, S. Hosono, A. Mikami, H. Nakamura, Y. Takashima, N. Nakamura, Y. Kuriyama, N. Ozaki, E. Furusyo, N. Ikezaki, H. Nakatochi, M. Sasakabe, T. Kawai, S. Okada, R. Hishida, A. Naito, M. Wakai, K. Momozawa, Y. Kubo, M. Tanaka, H, Sci Rep, 8, (1) ,   2018年01月, 査読有り
  • No association between HPV vaccine and reported post-vaccination symptoms in Japanese young women: Results of the Nagoya study, Suzuki, S. Hosono, A, Papillomavirus Res, 5, 96 - 103,   2018年
  • Patient-reported outcomes as assessment tools and predictors of long-term prognosis: a 7-year follow-up study of patients with rheumatoid arthritis, Masayo Kojima, Toshihisa Kojima, Sadao Suzuki, Nobunori Takahashi, Koji Funahashi, Shuji Asai, Yutaka Yoshioka, Kenya Terabe, Nobuyuki Asai, Toki Takemoto, Naoki Ishiguro, INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 20, (9) 1193 - 1200,   2017年09月, 査読有り, ObjectiveWhether the Boolean-based American College of Rheumatology/European League Against Rheumatism (EULAR) criteria for rheumatoid arthritis (RA) including patient-reported outcome measures (PROMs) for remission are strict for use in daily clinical practice is controversial. This study aimed to clarify the differences in the remission status defined by the criteria, including and excluding PROMs, and to identify the baseline predictors of long-term prognosis using 7-year follow-up data. MethodA total of 103 RA outpatients completed the baseline and 7-year follow-up questionnaire surveys. Pain visual analogue scale (VAS) of 1/10 was used as a PROM criterion for remission. ResultsOnly 10 patients achieved full-remission, whereas 18 met the partial-remission criteria excluding PROM at baseline. Although 70.0% of those who achieved full remission at baseline had full or partial remission status, 77.8% of those with partial remission were categorized as having no remission at 7 years. Significant baseline differences in the remission status at 7 years were observed with regard to disease duration, pain VAS, and physical function (Short Form 36 [SF-36]). Stepwise logistic regression analysis adjusted for age and sex identified disease duration and general health perception (SF-36) as independent predictors of full-remission. ConclusionRemission criteria including PROMs are stringent but important to achieve sustained remission. Early intensive treatment and efforts to improve patients' health perceptions may result in better prognosis for RA.
  • Genetic Variants of RAMP2 and CLR are Associated with Stroke, Koyama, T. Kuriyama, N. Ozaki, E. Matsui, D. Watanabe, I. Takeshita, W. Iwai, K. Watanabe, Y. Nakatochi, M. Shimanoe, C. Tanaka, K. Oze, I. Ito, H. Uemura, H. Katsuura-Kamano, S. Ibusuki, R. Shimoshikiryo, I. Takashima, N. Kadota, A. Kawai, S. Sasakabe, T. Okada, R. Hishida, A. Naito, M. Kuriki, K. Endoh, K. Furusyo, N. Ikezaki, H. Suzuki, S. Hosono, A. Mikami, H. Nakamura, Y. Kubo, M. Wakai, K, J Atheroscler Thromb, 24, (12) 1267 - 1281,   2017年09月, 査読有り
  • Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women, Sahoko Takagi, Mariko Naito, Sayo Kawai, Rieko Okada, Chisato Nagata, Satoyo Hosono, Yuichiro Nishida, Naoyuki Takashima, Sadao Suzuki, Ippei Shimoshikiryo, Haruo Mikami, Hirokazu Uemura, Nagato Kuriyama, Keizo Ohnaka, Michiaki Kubo, Nobuyuki Hamajima, Hideo Tanaka, Kenji Wakai, BRITISH JOURNAL OF NUTRITION, 118, (6) 463 - 472,   2017年09月, 査読有り, Although higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47-69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study. We documented dietary intakes, measured serum concentrations of oestrone (E1) and oestradiol (E2) and genotyped polymorphisms in oestrogen-metabolising CYP19A1 (rs4441215 and rs936306) and HSD17B1 (rs605059) genes. Trends and interactions were examined using linear regression models. In addition, we calculated the ratios of the oestrogen concentrations of the second to the highest quartiles (Q2-Q4) of dietary intake to those of the lowest quartiles (Q1). After adjustment for potential confounders, E2 was significantly associated with intake of carbohydrate and noodles; ratios of Q4 v. Q1 were 1.15 (95 % CI 1.04, 1.28) and 1.15 (95 % CI 1.04, 1.26), respectively. In contrast, E2 levels were inversely associated with intake of total energy, SFA and n-3 highly unsaturated fatty acids (n-3 HUFA); ratios of Q4 v. Q1 were 0.90 (95 % CI 0.82, 0.99), 0.89 (95 % CI 0.81, 0.98) and 0.91 (95 % CI 0.83, 1.00), respectively. In stratified analysis by polymorphisms, the rs605059 genotype of HSD17B1 significantly modified associations of E2 with intake of n-3 HUFA and fish; the associations were limited to those with the CC genotype. Macronutrient intakes were associated with serum E2 level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal women.
  • Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer, Okada Rieko, Naito Mariko, Hattori Yuta, Seiki Toshio, Wakai Kenji, Nanri Hinako, Watanabe Miki, Suzuki Sadao, Kairupan Sefanya Tara, Takashima Naoyuki, Mikami Haruo, Ohnaka Keizo, Watanabe Yoshiyuki, Sakurako Kamano, Kubo Michiaki, Hamajima Nobuyuki, Tanaka Hideo, Group Japan Multi-institutional Collaborative Cohort, Study The, Gastric Cancer, Vol.20, (No.2) 246 - 253,   2017年05月, 査読有り, A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/TIMP genes. We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35-69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study. Individuals who have two or more first-degree relatives (parents and siblings) with GC were categorized as having a multiple family history. Odds ratios (ORs) for multiple family history compared with no family history were calculated. MMP9 279QQ (rs17576) was more frequently observed in individuals whose both parents had a history of GC (n = 23) and in individuals for whom one parent and their sibling(s) had a history of GC (n = 36) compared with those with no family history (n = 3816) [30.4 % vs 11.6 %, OR 4.34, 95 % confidence interval (CI) 1.45-13.03 and 16.7 % vs 11.6 %, OR 2.26, 95 % CI 0.81-6.27 after adjustment for age, sex, and current smoking]. The population attributable fraction was 38.1 %. The haplotype MMP9-1562C/279Q/668Q was more frequently observed in individuals whose both parents had a history of GC and in individuals for whom one parent and their sibling(s) had a history of GC compared with those with no family history (OR 3.35, 95 % CI 0.75-14.96 and OR 3.51, 95 % CI 1.35-9.15 respectively). MMP9 polymorphisms were associated with a multiple family history of GC. Screening for these genotypes together with familial background may help us to identify individuals at an increased risk of GC.
  • Matrix metalloproteinase 9 gene polymorphisms are associated with a multiple family history of gastric cancer, Rieko Okada, Mariko Naito, Yuta Hattori, Toshio Seiki, Kenji Wakai, Hinako Nanri, Miki Watanabe, Sadao Suzuki, Tara Sefanya Kairupan, Naoyuki Takashima, Haruo Mikami, Keizo Ohnaka, Yoshiyuki Watanabe, Sakurako Katsuura-Kamano, Michiaki Kubo, Nobuyuki Hamajima, Hideo Tanaka, GASTRIC CANCER, 20, (2) 246 - 253,   2017年03月, 査読有り, A family history of gastric cancer (GC) is a well-known risk factor of GC. Genetic variations in genes of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) have been related to the risk of GC, but their association with familial background is not clear. We investigated whether individuals with a multiple family history of GC have more risk genotypes of MMP/TIMP genes. We genotyped ten common functional polymorphisms of MMP/TIMP genes in 4427 individuals aged 35-69 years without a history of GC who were enrolled in the Japan Multi-institutional Collaborative Cohort Study. Individuals who have two or more first-degree relatives (parents and siblings) with GC were categorized as having a multiple family history. Odds ratios (ORs) for multiple family history compared with no family history were calculated. MMP9 279QQ (rs17576) was more frequently observed in individuals whose both parents had a history of GC (n = 23) and in individuals for whom one parent and their sibling(s) had a history of GC (n = 36) compared with those with no family history (n = 3816) [30.4 % vs 11.6 %, OR 4.34, 95 % confidence interval (CI) 1.45-13.03 and 16.7 % vs 11.6 %, OR 2.26, 95 % CI 0.81-6.27 after adjustment for age, sex, and current smoking]. The population attributable fraction was 38.1 %. The haplotype MMP9-1562C/279Q/668Q was more frequently observed in individuals whose both parents had a history of GC and in individuals for whom one parent and their sibling(s) had a history of GC compared with those with no family history (OR 3.35, 95 % CI 0.75-14.96 and OR 3.51, 95 % CI 1.35-9.15 respectively). MMP9 polymorphisms were associated with a multiple family history of GC. Screening for these genotypes together with familial background may help us to identify individuals at an increased risk of GC.
  • Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change, Takahiro Higashibata, Kenji Wakai, Mariko Naito, Emi Morita, Asahi Hishida, Nobuyuki Hamajima, Megumi Hara, Sadao Suzuki, Satoyo Hosono, Naoyuld Takashima, Keizo Ohnaka, Akihiko Takada, Haruo Mikami, Yoshiyuki Watanabe, Hirokazu Uemura, Michiaki Kubo, Hideo Tanaka, GENE, 594, (1) 16 - 22,   2016年12月, 査読有り, SIRT1 acts as a cellular sensor to detect energy availability and modulates fat and glucose metabolism. This study assessed the effects of self-reported calorie restriction (CR) and exercise on correlations between SIRT1 polymorphisms and body mass index (BMI) and long-term weight change. This cross-sectional study enrolled 4023 subjects aged 35-69 years (1847 men and 2176 women) selected from participants in the Japan Multi-Institutional Collaborative Cohort Study. This study was based on a self-administered questionnaire. No significant correlations between SIRT1 polymorphisms and BMI or long-term weight change were found in either the CR or the active groups. In the no-CR group, women with the rs1467568 G allele had a higher BMI than women without (p = 0.02). Moreover, women with the rs7895833 A or rs1467568 G allele gained more weight from the age of 20 years than women without these alleles (p = 0.03 for rs7895833 and p = 0.003 for rs1467568). In addition, the odds ratios (95% confidence intervals) of these alleles for overweight (BMI >27.5 kg/m(2)) were significantly high in the no-CR women group (1.78 (1.06-2.99) for rs7895833 and 1.88 (1.13-3.15) for rs1467568) but not in the CR group. The results of this study suggest that CR might override the genetic contributions of the SIRT1 rs7895833 A and rs1467568 G alleles to BMI and long-term weight change. (C) 2016 Elsevier B.V. All rights reserved.
  • Liver-related safety assessment of green tea extracts in humans: a systematic review of randomized controlled trials, Isomura, T. Suzuki, S. Origasa, H. Hosono, A. Suzuki, M. Sawada, T. Terao, S. Muto, Y. Koga, T, Eur J Clin Nutr, 70, (11) 1221 - 1229,   2016年11月, 査読有り
  • Diabetes Mellitus and Risk of Colorectal Cancer Mortality in Japan: the Japan Collaborative Cohort Study, Tan, C. Mori, M. Adachi, Y. Wakai, K. Suzuki, S. Suzuki, K. Hashimoto, Sh Watanabe, Y. Tamakoshi, A, Asian Pac J Cancer Prev, 17, (10) 4681 - 4688,   2016年10月, 査読有り
  • Associations between Dietary Patterns, ADR2 Gln27Glu and ADR3 Trp64Arg with Regard to Serum Triglyceride Levels: J-MICC Study, Hinako Nanri, Yuichiro Nishida, Kazuyo Nakamura, Keitaro Tanaka, Mariko Naito, Guang Yin, Nobuyuki Hamajima, Naoyuki Takashima, Sadao Suzuki, Yora Nindita, Michiko Kohno, Hirokazu Uemura, Teruhide Koyama, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, NUTRIENTS, 8, (9) ,   2016年09月, 査読有り, Interactions between dietary patterns and 2 -adrenergic receptor (ADR) gene polymorphisms (ADR2 Gln27Glu and ADR3 Trp64Arg) were examined with regard to the effects on serum triglyceride levels. The cross-sectional study comprised 1720 men and women (aged 35-69 years) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Genotyping was conducted using a multiplex polymerase chain reaction-based invader assay. We used 46 items from a validated short food frequency questionnaire and examined major dietary patterns by factor analysis. We identified four dietary patterns: healthy, Western, seafood and bread patterns. There was no significant association between any dietary pattern and serum triglyceride levels. After a separate genotype-based analysis, significant interactions between ADR3 Trp64Arg genotype and the bread pattern (p for interaction = 0.01) were associated with serum triglyceride levels; specifically, after adjusting for confounding factors, Arg allele carriers with the bread pattern had lower serum triglycerides (p for trend = 0.01). However, the Trp/Trp homozygous subjects with the bread pattern showed no association with serum triglycerides (p for trend = 0.55). Interactions between other dietary patterns and ADR polymorphisms were not significant for serum triglyceride levels. Our findings suggest that ADR3 polymorphism modifies the effects of the bread pattern on triglyceride levels.
  • Variant of the clock circadian regulator (CLOCK) gene and related haplotypes are associated with the prevalence of type 2 diabetes in the Japanese population, Uemura, H. Katsuura-Kamano, S. Yamaguchi, M. Arisawa, K. Hamajima, N. Hishida, A. Kawai, S. Oze, I. Shinchi, K. Takashima, N. Suzuki, S. Nakahata, N. Mikami, H. Ohnaka, K. Kuriyama, N. Kubo, M. Tanaka, H. Japan Multi-Institutional Collaborative Cohort Study, Group, J Diabetes, 8, (5) 667 - 76,   2016年09月, 査読有り
  • Effects of self-reported calorie restriction on correlations between SIRT1 polymorphisms and body mass index and long-term weight change., Higashibata T, Wakai K, Naito M, Morita E, Hishida A, Hamajima N, Hara M, Suzuki S, Hosono S, Takashima N, Ohnaka K, Takada A, Mikami H, Watanabe Y, Uemura H, Kubo M, Tanaka H, Gene, Vol.594, (No.1) 16 - 22,   2016年08月31日, 査読有り, SIRT1 acts as a cellular sensor to detect energy availability and modulates fat and glucose metabolism. This study assessed the effects of self-reported calorie restriction (CR) and exercise on correlations between SIRT1 polymorphisms and body mass index (BMI) and long-term weight change. This cross-sectional study enrolled 4023 subjects aged 35-69years (1847 men and 2176 women) selected from participants in the Japan Multi-Institutional Collaborative Cohort Study. This study was based on a self-administered questionnaire. No significant correlations between SIRT1 polymorphisms and BMI or long-term weight change were found in either the CR or the active groups. In the no-CR group, women with the rs1467568 G allele had a higher BMI than women without (p=0.02). Moreover, women with the rs7895833 A or rs1467568 G allele gained more weight from the age of 20years than women without these alleles (p=0.03 for rs7895833 and p=0.003 for rs1467568). In addition, the odds ratios (95% confidence intervals) of these alleles for overweight (BMI >27.5kg/m(2)) were significantly high in the no-CR women group (1.78 (1.06-2.99) for rs7895833 and 1.88 (1.13-3.15) for rs1467568) but not in the CR group. The results of this study suggest that CR might override the genetic contributions of the SIRT1 rs7895833 A and rs1467568 G alleles to BMI and long-term weight change.
  • ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men., Yin G, Naito M, Wakai K, Morita E, Kawai S, Hamajima N, Suzuki S, Kita Y, Takezaki T, Tanaka K, Morita M, Uemura H, Ozaki E, Hosono S, Mikami H, Kubo M, Tanaka H, Japan Multi-institutional Collaborative Cohort, J-MICC, Study Group, Nagoya journal of medical science, 78, (2) 183 - 193,   2016年05月, 査読有り
  • Intraindividual dynamics of transcriptome and genome-wide stability of DNA methylation, Ryohei Furukawa, Tsuyoshi Hachiya, Hideki Ohmomo, Yuh Shiwa, Kanako Ono, Sadafumi Suzuki, Mamoru Satoh, Jiro Hitomi, Kenji Sobue, Atsushi Shimizu, SCIENTIFIC REPORTS, 6,   2016年05月, 査読有り, Cytosine methylation at CpG dinucleotides is an epigenetic mechanism that affects the gene expression profiles responsible for the functional differences in various cells and tissues. Although gene expression patterns are dynamically altered in response to various stimuli, the intraindividual dynamics of DNA methylation in human cells are yet to be fully understood. Here, we investigated the extent to which DNA methylation contributes to the dynamics of gene expression by collecting 24 blood samples from two individuals over a period of 3 months. Transcriptome and methylome association analyses revealed that only similar to 2% of dynamic changes in gene expression could be explained by the intraindividual variation of DNA methylation levels in peripheral blood mononuclear cells and purified monocytes. These results showed that DNA methylation levels remain stable for at least several months, suggesting that disease-associated DNA methylation markers are useful for estimating the risk of disease manifestation.
  • Re: Thyroid Cancer Among Young People in Fukushima, Suzuki, S, Epidemiology, 27, (3) ,   2016年05月, 査読有り
  • ALDH2 polymorphism is associated with fasting blood glucose through alcohol consumption in Japanese men, Yin, G. Naito, M. Wakai, K. Morita, E. Kawai, S. Hamajima, N. Suzuki, S. Kita, Y. Takezaki, T. Tanaka, K. Morita, M. Uemura, H. Ozaki, E. Hosono, S. Mikami, H. Kubo, M. Tanaka, H. Japan Multi-institutional Collaborative Cohort, Study Group, Nagoya J Med Sci, 78, (2) 183 - 93,   2016年05月, 査読有り
  • Changes in blood biochemical markers before, during, and after a 2-day ultramarathon, Arakawa, K. Hosono, A. Shibata, K. Ghadimi, R. Fuku, M. Goto, C. Imaeda, N. Tokudome, Y. Hoshino, H. Marumoto, M. Kobayashi, M. Suzuki, S. Tokudome, S, Open Access J Sports Med, 7, 43 - 50,   2016年04月, 査読有り
  • Weight Gain and Alcohol Drinking Associations with Breast Cancer Risk in Japanese Postmenopausal Women - Results from the Japan Collaborative Cohort (JACC) Study, Nitta, J. Nojima, M. Ohnishi, H. Mori, M. Wakai, K. Suzuki, S. Fujino, Y. Lin, Y. Tamakoshi, K. Tamakoshi, A, Asian Pac J Cancer Prev, 17, (3) 1437 - 43,   2016年04月, 査読有り
  • Rare Helicobacter pylori Infection May Explain Low Stomach Cancer Incidence: Ecological Observations in Bali, Indonesia, Tanaka, T. Mulyadi, I. K. Moestikaningsih, Oka, T. G. Soeripto, Triningsih, F. E. Triyono, T. Heriyanto, D. S. Hosono, A. Suzuki, S. Tokudome, S, Asian Pac J Cancer Prev, 17, (3) 979 - 84,   2016年04月, 査読有り
  • Influence of cigarette smoking and inflammatory gene polymorphisms on glycated hemoglobin in the Japanese general population, Nishida, Y. Hara, M. Sakamoto, T. Shinchi, K. Kawai, S. Naito, M. Hamajima, N. Kadota, A. Suzuki, S. Ibusuki, R. Hirata, A. Yamaguchi, M. Kuriyama, N. Oze, I. Mikami, H. Kubo, M. Tanaka, H. Japan Multi-Institutional Collaborative Cohort Study, Group, Prev Med Rep, 3, (158) 288 - 95,   2016年03月, 査読有り
  • 血清硫酸デヒドロエピアンドロステロンサルフェイト濃度, 荒井 健介, 細野 晃弘, 西山 毅, 小嶋 雅代, 柴田 清, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 菊地 正悟, 山田 珠樹, 鈴木 貞夫, Nagoya Medical Journal, 55, (1) 1 - 13,   2016年
  • Endoscopic management of familial adenomatous polyposis in patients refusing colectomy, Hideki Ishikawa, Michihiro Mutoh, Takeo Iwama, Sadao Suzuki, Takashi Abe, Yoji Takeuchi, Tomiyo Nakamura, Yasumasa Ezoe, Gen Fujii, Keiji Wakabayashi, Takeshi Nakajima, Toshiyuki Sakai, ENDOSCOPY, 48, (1) 51 - 55,   2016年01月, 査読有り, Background and study aims: Colectomy protects against colorectal cancer in familial adenomatous polyposis (FAP); however, some patients with FAP refuse surgery. The aim of this study was to evaluate the feasibility and safety of endoscopic management of these patients. Patients and methods: A retrospective review of medical records was performed to identify adult patients with FAP who refused colectomy and were managed by repeated colonoscopies to remove numerous polyps between 2001 and 2012. Polyps were removed by hot snare polypectomy or endoscopic mucosal resection. Polyps of <10 mm in size and without endoscopic features suggesting cancer were discarded without histological examination; the remaining polyps were examined histologically. Results: Of the 95 eligible patients, five (5.3 %) were excluded. The remaining 90 patients (median age at first visit 29 years [range 16-68 years]; 46 males) were followed for a median of 5.1 years (interquartile range [IQR] 3.3-7.3 years). During this period, a total of 55701 polyps were resected without adverse events such as bleeding or perforation. The median numbers of endoscopic treatment sessions and polyps removed per patient were 8 (IQR 6-11) and 475 (IQR 211-945), respectively. Five patients had noninvasive carcinoma (Category 4.2 according to the revised Vienna classification), detected within 10 months from the start of the follow-up period. All of these patients were treated endoscopically, without signs of recurrence during a median follow-up of 4.3 years (IQR 2.0-7.1 years). No invasive colorectal cancer was recorded during the study period. Two patients (2.2 %) underwent colectomy because the polyposis phenotype had changed to dense polyposis. Conclusion: Endoscopic management of FAP is feasible and safe in the medium term.
  • Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum sex hormone level among postmenopausal Japanese women., Satoyo Hosono, Hidemi Ito, Isao Oze, Yasuki Higaki, Emi Morita, Naoyuki Takashima, Sadao Suzuki, Keiichi Shimatani, Haruo Mikami, Keizo Ohnaka, Etsuko Ozaki, Sakurako Katsuura-Kamano, Michiaki Kubo, Chisato Nagata, Mariko Naito, Nobuyuki Hamajima, Hideo Tanaka, Maturitas, 82, (4) 394 - 401,   2015年12月, 査読有り, OBJECTIVE: Extraovarian sex hormone production plays an important role in estrogen biosynthesis in postmenopausal women. We examined possible associations between serum sex hormone level and polymorphisms in CYP19A1, HSD17B1, and HSD17B2. We also assessed possible interaction between these polymorphisms and current overweight. METHODS: We conducted a cross-sectional study. 785 Japanese natural postmenopausal women were randomly selected from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study database. Information on lifestyle factors was obtained from a self-administered questionnaire. Serum estrogens and androgens levels were measured by liquid chromatography-tandem mass spectrometry. Four tag SNPs (single nucleotide polymorphisms) of CYP19A1, one missense SNP of HSD17B1 and three tag SNPs of HSD17B2 were examined by Invader assay. A trend test was conducted using linear regression. RESULTS: After adjustment for multiple comparisons, we found that rs4441215 and rs936306 in CYP19A1 and rs4888202 and rs2955160 in HSD17B2 were associated with differences in serum estrone level. Further, rs4441215 and rs936306 were associated with differences in serum estradiol level. None of these polymorphisms showed a significant interaction with current body mass index (BMI). CONCLUSIONS: Our findings suggested that CYP19A1 and HSD17B2 polymorphisms might be associated with circulating sex hormone levels in Japanese postmenopausal women, independent of current BMI.
  • Genetic variants of SLC17A1 are associated with cholesterol homeostasis and hyperhomocysteinaemia in Japanese men., Teruhide Koyama, Daisuke Matsui, Nagato Kuriyama, Etsuko Ozaki, Keitaro Tanaka, Isao Oze, Nobuyuki Hamajima, Kenji Wakai, Rieko Okada, Kokichi Arisawa, Haruo Mikami, Keiichi Shimatani, Akie Hirata, Naoyuki Takashima, Sadao Suzuki, Chisato Nagata, Michiaki Kubo, Hideo Tanaka, Scientific reports, 5, 15888 - 15888,   2015年11月03日, 査読有り, Hyperuricaemia is an undisputed and highly predictive biomarker for cardiovascular risk. SLC17A1, expressed in the liver and kidneys, harbours potent candidate single nucleotide polymorphisms that decrease uric acid levels. Therefore, we examined SLC17A1 polymorphisms (rs1165196, rs1179086, and rs3757131), which might suppress cardiovascular risk factors and that are involved in liver functioning, via a large-scale pooled analysis of the Japanese general population in a cross-sectional study. Using data from the Japan Multi-Institutional Collaborative Cohort Study, we identified 1842 participants of both sexes, 35-69-years-old, having the requisite data, and analysed their SLC17A1 genotypes. In men, logistic regression analyses revealed that minor alleles in SLC17A1 polymorphisms (rs1165196 and rs3757131) were associated with a low-/high-density lipoprotein cholesterol ratio >2.0 (rs1165196: odds ratio [OR], 0.703; 95% confidence interval [CI], 0.536-0.922; rs3757131: OR, 0.658; 95% CI, 0.500-0.866), and with homocysteine levels of >10.0 nmol/mL (rs1165196: OR, 0.544; 95% CI, 0.374-0.792; rs3757131: OR, 0.509; 95% CI, 0.347-0.746). Therefore, these polymorphisms had dominant negative effects on cholesterol homeostasis and hyperhomocysteinaemia, in men, independent of alcohol consumption, physical activity, or daily energy and nutrition intake. Thus, genetic variants of SLC17A1 are potential biomarkers for altered cholesterol homeostasis and hyperhomocysteinaemia in Japanese men.
  • Associations between polymorphisms of interleukin-6 and related cytokine genes and serum liver damage markers: a cross-sectional study in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study., Sugimoto Y, Wakai K, Nakagawa H, Suma S, Sasakabe T, Sakamoto T, Takashima N, Suzuki S, Ogawa S, Ohnaka K, Kuriyama N, Arisawa K, Mikami H, Kubo M, Hosono S, Hamajima N, Tanaka H, J-MICC Study Group, Gene, 557, (2) 158 - 162,   2015年02月, 査読有り
  • Effects of telephone-delivered lifestyle support on the development of diabetes in participants at high risk of type 2 diabetes: J-DOIT1, a pragmatic cluster randomised trial, Sakane N, Konani K, Takahashi K, Sano Y, Tsuzaki K, Okazaki K, Sato J, Suzuki S, Morita S, Oshima Y, Izumi K, Kato M, Ishizuka N, Noda M, Kuzuya H, BMJ Open, 5, (e007316) ,   2015年, 査読有り
  • Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study, Yamaguchi M, Uemura H, Arisawa K, Katsuura-kamano S, Hamajima N, Hishida A, Suma S, Oze I, Nakamura K, Takashima N, Suzuki S, Ibusuki R, Mikami H, Ohnaka K, Kuriyama N, Kubo M, Tanaka H, Japan Multi-institutional Collaborative Cohort, J-MICC, Study Group, Diabetes Res Clin Pract, 110, 301 - 308,   2015年, 査読有り
  • Patient-reported outcomes as assessment tools and predictors of long-term prognosis: a 7-year follow-up study of patients with rheumatoid arthritis, Kojima M, Kojima T, Suzuki S, Takahashi N, Funahashi K, Asai S, Yoshioka Y, Terabe K, Asai N, Takemoto T, Ishiguro N, Int J Rheum Dis, (12789) ,   2015年, 査読有り
  • [Complementary estimate of the Great East Japan Earthquake for the numbers of households and patients from national health statistics surveys]., Hashimoto S, Kawado M, Yamada H, Suzuki S, Mieno M, Tomata Y, Murakami Y, [Nihon koshu eisei zasshi] Japanese journal of public health, 62, (10) 617 - 623,   2015年, 査読有り
  • Polymorphisms in CYP19A1, HSD17B1 and HSD17B2 genes and serum. sex hormone level among postmenopausal Japanese women, Hosono, Satoyo, Ito, Hidemi, Oze, Isao, Higaki, Yasuki, Morita, Emi, Takashima, Naoyuki, Suzuki, Sadao, Shimatani, Keiichi, Mikami, Haruo, Ohnaka, Keizo, Ozaki, Etsuko, Katsuura-Kamano, Sakurako, Kubo, Michiaki, Nagata, Chisato, Naito, Mariko, Hamajima, Nobuyuki, Tanaka, Hideo, J-MICC Study Grp, MATURITAS, 82, (4) 394 - 401,   2015年
  • Influence of Municipal- and Individual-level Socioeconomic Conditions on Mortality in Japan, Kaori Honjo, Hiroyasu Iso, Yoshiharu Fukuda, Nobuo Nishi, Tomoki Nakaya, Yoshihisa Fujino, Naohito Tanabe, Sadao Suzuki, S. V. Subramanian, Akiko Tamakoshi, INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE, 21, (5) 737 - 749,   2014年10月, 査読有り, The health effect of area socioeconomic conditions has been evident especially in Western countries; however, limited research has focused on the effect of municipal-level socioeconomic conditions, especially in Asia. Multilevel research using data from the Japan Collaborative Cohort Study, a large cohort study followed from 1990 to 2006, was conducted to examine individual as well as municipal socioeconomic conditions on risk of death, adjusting for each other. We included 24,460 men and 32,649 women aged 40 to 65 years at baseline in 35 municipalities as our study population. Primary predictors were municipal socioeconomic conditions (proportion of college graduates, per capita income, unemployment rate, and proportion of households receiving public assistance) and individual socioeconomic conditions (education level and occupation). Among men, the multilevel logistic estimate (standard errors) of proportion of college graduates and unemployment rate for mortality from cardiovascular disease were -0.399 (0.094) and -0.343 (0.122), respectively. Among women, the multilevel logistic estimate (standard errors) of proportion of college graduates and per capita annual income for mortality from injuries were -0.386 (0.171) and -1.069 (0.407). Individual education level and occupation were associated with all-cause mortality, in particular, mortality from cardiovascular disease or injuries. Interactions between individual education level and indicators of municipal socioeconomic conditions were observed for mortality from cancer and cardiovascular disease among men and mortality from injuries among women. Municipal and individual socioeconomic conditions were independently and interactively associated with premature death; this suggests that reducing social inequalities in health demands a focus on municipal conditions in addition to those of individuals.
  • A polymorphism near MC4R gene (rs17782313) is associated with serum triglyceride levels in the general Japanese population: the J-MICC Study., Katsuura-Kamano S, Uemura H, Arisawa K, Yamaguchi M, Hamajima N, Wakai K, Okada R, Suzuki S, Taguchi N, Kita Y, Ohnaka K, Kairupan TS, Matsui D, Oze I, Mikami H, Kubo M, Tanaka H, Endocrine, 47, (1) 81 - 89,   2014年09月, 査読有り
  • Comprehensive Comparison of Self-administered Questionnaires for Measuring Quantitative Autistic Traits in Adults, Takeshi Nishiyama, Masako Suzuki, Katsunori Adachi, Satoshi Sumi, Kensuke Okada, Hirohisa Kishino, Saeko Sakai, Yoko Kamio, Masayo Kojima, Sadao Suzuki, Stephen M. Kanne, JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 44, (5) 993 - 1007,   2014年05月, 査読有り, We comprehensively compared all available questionnaires for measuring quantitative autistic traits (QATs) in terms of reliability and construct validity in 3,147 non-clinical and 60 clinical subjects with normal intelligence. We examined four full-length forms, the Subthreshold Autism Trait Questionnaire (SATQ), the Broader Autism Phenotype Questionnaire, the Social Responsiveness Scale2-Adult Self report (SRS2-AS), and the Autism-Spectrum Quotient (AQ). The SRS2-AS and the AQ each had several short forms that we also examined, bringing the total to 11 forms. Though all QAT questionnaires showed acceptable levels of test-re-test reliability, the AQ and SRS2-AS, including their short forms, exhibited poor internal consistency and discriminant validity, respectively. The SATQ excelled in terms of classical test theory and due to its short length.
  • Criterion validity of the Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale for the diagnosis of sleep disorders, Takeshi Nishiyama, Tomoki Mizuno, Masayo Kojima, Sadao Suzuki, Tsuyoshi Kitajima, Kayoko Bhardwaj Ando, Shinichi Kuriyama, Meiho Nakayama, SLEEP MEDICINE, 15, (4) 422 - 429,   2014年04月, 査読有り, Objectives: (1) To examine criterion validity of the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) using obstructive sleep apnea (OSA), periodic limb movement disorder (PLMD), rapid eye movement sleep behavior disorder (RBD), and narcolepsy as criterion standard. (2) To summarize the evidence for criterion validity of the ESS for the diagnosis of OSA by a meta-analysis that combines the current and previous studies. (3) To investigate the determinants of the PSQI and ESS scores. Methods: The PSQI and ESS as well as the Hospital Anxiety and Depression Scale (HADS), which measures anxiety and depression levels, were administered to 367 patients consecutively referred to a sleep clinic. They underwent overnight polysomnography (PSG) and the multiple sleep latency test if narcolepsy was suspected. Results: The area under the receiver operating characteristic curves for the ESS and PSQI (and its sub-scale) were <0.9, meaning that these questionnaires were not highly accurate for predicting the four sleep disorders. The meta-analysis found that the ESS had no value in identifying OSA. The variable that most strongly influenced PSQI or ESS scores was the HADS score. Conclusion: The PSQI and ESS should no longer be used as a screening or diagnostic instrument for the four PSG-defined sleep disorders, especially in a low-risk population. (C) 2014 Elsevier B. V. All rights reserved.
  • GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: data from the J-MICC Study, Hishida Asahi, Takashima Naoyuki, Turin Chowdhury Tanvir, Kawai Sayo, Wakai Kenji, Hamajima Nobuyuki, Hosono Satoyo, Nishida Yuichiro, Suzuki Sadao, Nakahata Noriko, Mikami Haruo, Ohnaka Keizo, Matsui Daisuke, Sakurako Kamano, Kubo Michiaki, Tanaka Hideo, Kita Yoshikuni, Journal of Nephrology, Vol.27, (No.2) 143 - 149,   2014年04月, 査読有り, Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of glucokinase and glucokinase regulatory protein (GCKR) polymorphisms with the risk of CKD in Japan, we examined this association among Japanese individuals using cross-sectional data. The subjects for this analysis were 3,314 consecutively selected participants from the Japan Multi-Institutional Collaborative Cohort Study. Age- and sex- adjusted odds ratios (aORs) of CKD stages 3-5 were calculated for each genotype by logistic regression and the effects of genotype on estimated glomerular filtration rate were evaluated by linear regression. Gene-environment interaction was also investigated based on questionnaire information. When subjects with GCKR rs780094 G/A and G/G, or GCKR rs1260326 T/C and C/C were combined together and compared with the references (GCKR rs780094 A/A or GCKR rs1260326 T/T), the aORs were 0.84 (0.69-1.02) or 0.81 (0.67-0.99) (p = 0.075 or 0.037), respectively. A significant OR for interaction between GCKR rs1260326 T/T and current smoking (OR = 1.79, p = 0.041) was also observed. The present study suggests a possible association of the T/T genotype of GCKR rs1260326 polymorphism with elevated risk of CKD and its interaction with current smoking, which may support the possibility of performing risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.
  • GCK, GCKR polymorphisms and risk of chronic kidney disease in Japanese individuals: Data from the J-MICC Study, Hishida A, Takashima N, Turin T.C, Kawai S, Wakai K, Hamajima N, Hosono S, Nishida Y, Suzuki S, Nakahata N, Mikami H, Ohnaka K, Matsui D, Katsuura-Kamano S, Kubo M, Tanaka H, Kita Y, Journal of Nephrology, 27, (2) 143 - 149,   2014年04月, 査読有り
  • Comprehensive comparison of self-administered questionnaires for measuring quantitative autistic traits in adults., Nishiyama T, Suzuki M, Adachi K, Sumi S, Okada K, Kishino H, Sakai S, Kamio Y, Kojima M, Suzuki S, Kanne SM, J Autism Dev Disord, 44, 993 - 1007,   2014年
  • キャンパス敷地内全面禁煙に伴う医学生への防煙教育の必要性, 藤田 ひとみ, 小嶋 雅代, 永谷 照男, 細野 晃弘, 荒井 健介, 辻村 尚子, 岡 京子, 岡本 尚子, 神谷 真有美, 鈴木 美奈, 近藤 文, 鈴木 貞夫, 東海公衆衛生雑誌, 2, 77 - 83,   2014年
  • Low intake of vegetables and fruits and risk of colorectal cancer: the Japan Collaborative Cohort Study., Aoyama N, Kawado M, Yamada H, Hashimoto S, Suzuki K, Wakai K, Suzuki S, Watanabe Y, Tamakoshi A, Journal of epidemiology / Japan Epidemiological Association, 24, (5) 353 - 360,   2014年, 査読有り
  • Coffee consumption and risk of colorectal cancer: the Japan Collaborative Cohort Study., Yamada H, Kawado M, Aoyama N, Hashimoto S, Suzuki K, Wakai K, Suzuki S, Watanabe Y, Tamakoshi A, JACC Study Group, Journal of epidemiology / Japan Epidemiological Association, 24, (5) 370 - 378,   2014年, 査読有り
  • Associations between hOGG1 Ser326Cys polymorphism and increased body mass index and fasting glucose level in the Japanese general population., Hara M, Nakamura K, Nanri H, Nishida Y, Hishida A, Kawai S, Hamajima N, Kita Y, Suzuki S, Mantjoro EM, Ohnaka K, Uemura H, Matsui D, Oze I, Mikami H, Kubo M, Tanaka H, Japan Multi-Institutional Collaborative Cohort, J-MICC, Study Group, Journal of epidemiology / Japan Epidemiological Association, 24, 379 - 384,   2014年, 査読有り
  • Polymorphisms of genes involved in lipid metabolism and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study, Hishida, Asahi, Wakai, Kenji, Naito, Mariko, Suma, Shino, Sasakabe, Tae, Hamajima, Nobuyuki, Hosono, Satoyo, Horita, Mikako, Turin, Tanvir Chowdhury, Suzuki, Sadao, Kairupan, Tara Sefanya, Mikami, Haruo, Ohnaka, Keizo, Watanabe, Isao, Uemura, Hirokazu, Kubo, Michiaki, Tanaka, Hideo, J-MICC Study Grp, LIPIDS IN HEALTH AND DISEASE, 13,   2014年
  • Peripheral natural killer cell activity as a predictor of recurrent pregnancy loss: a large cohort study., Kinue Katano, Sadao Suzuki, Yasuhiko Ozaki, Nobuhiro Suzumori, Tamao Kitaori, Mayumi Sugiura-Ogasawara, Fertility and sterility, 100, (6) 1629 - 34,   2013年12月, 査読有り, OBJECTIVE: To determine the predictive value of preconceptional peripheral blood natural killer (pNK) cell activity in patients with recurrent pregnancy loss (RPL). DESIGN: Cohort study. SETTING: University department. PATIENT(S): A total of 552 patients with a history of two to six consecutive miscarriages. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The predictive value of preconceptional pNK cell activity for subsequent miscarriage was analyzed using multivariable logistic regression analysis, with age, number of previous miscarriages, and presence/absence of previous live births and bed rest as covariates. RESULT(S): Age and number of previous miscarriages, but not high pNK cell activity, were found to be independent risk factors for a subsequent miscarriage. No effect of bed rest and previous live birth on the likelihood of live birth was observed (odds ratios 1.28 [95% confidence interval 0.81-2.02] and 0.91 [0.52-1.59], respectively). CONCLUSION(S): Elevated pNK cell activity was found to not be an independent risk factor for subsequent miscarriage. Clinicians should not measure the plasma NK activity as a systematic recurrent pregnancy loss examination, because its clinical significance is yet to be established.
  • Gene-Gene Combination Effect and Interactions among ABCA1, APOA1, SR-B1, and CETP Polymorphisms for Serum High-Density Lipoprotein-Cholesterol in the Japanese Population, Akihiko Nakamura, Hideshi Niimura, Kazuyo Kuwabara, Toshiro Takezaki, Emi Morita, Kenji Wakai, Nobuyuki Hamajima, Yuichiro Nishida, Tanvir Chowdhury Turin, Sadao Suzuki, Keizo Ohnaka, Hirokazu Uemura, Etsuko Ozaki, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, PLOS ONE, 8, (12) ,   2013年12月, 査読有り, Background/Objective: Gene-gene interactions in the reverse cholesterol transport system for high-density lipoprotein-cholesterol (HDL-C) are poorly understood. The present study observed gene-gene combination effect and interactions between single nucleotide polymorphisms (SNPs) in ABCA1, APOA1, SR-81, and CETP in serum HDL-C from a cross-sectional study in the Japanese population. Methods:The study population comprised 1,535 men and 1,515 women aged 35-69 years who were enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We selected 13 SNPs in the ABCA1, APOA1, CETP, and SR-81 genes in the reverse cholesterol transport system. The effects of genetic and environmental factors were assessed using general linear and logistic regression models after adjusting for age, sex, and region. Principal Findings: Alcohol consumption and daily activity were positively associated with HDL-C levels, whereas smoking had a negative relationship. The T allele of CETP, rs3764261, was correlated with higher HDL-C levels and had the highest coefficient (2.93 mg/dL/allele) among the 13 SNPs, which was statistically significant after applying the Bonferroni correction (p<0.001). Gene-gene combination analysis revealed that CETP rs3764261 was associated with high HDL-C levels with any combination of SNPs from ABCA1, APOA1, and SR-B1, although no gene-gene interaction was apparent. An increasing trend for serum HDL-C was also observed with an increasing number of alleles (p<0.001). Conclusions:The present study identified a multiplier effect from a polymorphism in CETP with ABCA1, APOA1, and SR-B1, as well as a dose-dependence according to the number of alleles present.
  • MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study, Asahi Hishida, Rieko Okada, Yin Guang, Mariko Naito, Kenji Wakai, Satoyo Hosono, Kazuyo Nakamura, Tanvir Chowdhury Turin, Sadao Suzuki, Hideshi Niimura, Haruo Mikami, Jun Otonari, Nagato Kuriyama, Sakurako Katsuura, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima, INTERNATIONAL UROLOGY AND NEPHROLOGY, 45, (6) 1613 - 1620,   2013年12月, Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data. The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype. When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 % CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (< 7.4 ng/ml) or high (a parts per thousand yen7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.
  • Genome-Wide Association Study of Genetic Factors Related to Confectionery Intake: Potential Roles of the ADIPOQ Gene, Kenji Wakai, Keitaro Matsuo, Fumihiko Matsuda, Ryo Yamada, Meiko Takahashi, Takahisa Kawaguchi, Yasushi Yatabe, Hidemi Ito, Satoyo Hosono, Kazuo Tajima, Mariko Naito, Emi Morita, Guang Yin, Tatsuhiko Sakamoto, Naoyuki Takashima, Sadao Suzuki, Noriko Nakahata, Haruo Mikami, Keizo Ohnaka, Yoshiyuki Watanabe, Kokichi Arisawa, Michiaki Kubo, Nobuyuki Hamajima, Hideo Tanaka, OBESITY, 21, (11) 2413 - 2419,   2013年11月, Objective: The excessive consumption of confectionery might have adverse effects on human health. To screen genetic factors associated with confectionery-intake frequency, a genome-wide association study (GWAS) in Japan was conducted. Design and Methods: For the discovery phase (stage 1), we conducted a GWAS of 939 noncancer patients in a cancer hospital. Additive models were used to test associations between genotypes of approximately 500,000 single-nucleotide polymorphisms (SNPs) and the confectionery-intake score (based on intake frequency). We followed-up association signals with P < 1 x 10(-5) and minor allele frequency >0.01 in stage 1 by genotyping the SNPs of 4,491 participants in a cross-sectional study within a cohort (replication phase [stage 2]). Results: We identified 12 SNPs in stage 1 that were potentially related to confectionery intake. In stage 2, this association was replicated for one SNP (rs822396; P = 0.049 for stage 2 and 4.2 x 10(-5) for stage 1+2) in intron 1 of the ADIPOQ gene, which encodes the adipokine adiponectin. Conclusions: Given the biological plausibility and previous relevant findings, the association of an SNP in the ADIPOQ gene with a preference for confectionery is worthy of follow-up and provides a good working hypothesis for experimental testing.
  • Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss., Yuko Hayashi, Hidefumi Sasaki, Sadao Suzuki, Takeshi Nishiyama, Tamao Kitaori, Eita Mizutani, Nobuhiro Suzumori, Mayumi Sugiura-Ogasawara, Fertility and sterility, 100, (4) 1018 - 24,   2013年10月, 査読有り, OBJECTIVE: To investigate whether polymorphisms at the promoter or 5'-untranslated region of annexin A5 gene (ANXA5) influence miscarriage. DESIGN: Case-control study and nested case-control study. SETTING: Hospitals. PATIENT(S): A total of 264 patients with two to nine recurrent pregnancy losses (RPLs) and 195 fertile control subjects. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): The frequency of six single-nucleotide polymorphisms (SNPs) of the ANXA5 gene in RPL patients versus control subjects, and subsequent live birth rate with and without risk alleles in RPL patients. RESULT(S): The minor allele was significantly more frequent in RPL patients than in control subjects for SNP5 (rs1050606). The live birth rates of patients with and without risk alleles of SNP5 were 84.0% and 84.3%, respectively, after excluding cases with abnormal embryonic karyotype, with no significant difference. CONCLUSION(S): The variations with the ANXA5 gene upstream region, especially SNP5, were confirmed to be risk factors of RPL. However, presence/absence of the ANXA5 risk allele did not have any predictive effect for subsequent pregnancy outcome. This was the first study indicating the influence of ANXA5 SNP5 for pregnancy outcome.
  • Ovarian cancer mortality among women aged 40-79 years in relation to reproductive factors and body mass index: Latest evidence from the Japan collaborative cohort study, Khan M.M.H, Khan A, Nojima M, Suzuki S, Fujino Y, Tokudome S, Tamakoshi K, Mori M, Tamakoshi A, Journal of Gynecologic Oncology, 24, (3) 249 - 257,   2013年07月, 査読有り
  • Polymorphisms in genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) and risk of chronic kidney disease in Japanese - cross-sectional data from the J-MICC study, Asahi Hishida, Rieko Okada, Mariko Naito, Emi Morita, Kenji Wakai, Nobuyuki Hamajima, Satoyo Hosono, Hinako Nanri, Tanvir Chowdhury Turin, Sadao Suzuki, Kazuyo Kuwabara, Haruo Mikami, Sanjeev Budhathoki, Isao Watanabe, Kokichi Arisawa, Michiaki Kubo, Hideo Tanaka, JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, 53, (1) 15 - 20,   2013年07月, Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the association of polymorphisms in the genes encoding antioxidant enzymes (SOD2, CAT, GPx, TXNRD, SEPP1, SEP15 and SELS) with the risk of CKD in Japanese, we examined this association using the cross-sectional data of Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. The subjects were 3,285 men and women, aged 35-69 years, selected from J-MICC Study participants for whom genotyping were conducted by multiplex polymerase chain reaction-based Invader assay. The prevalence of CKD was determined for CKD stages 3-5 (eGFR <60 ml/min/1.73 m(2)). When those with CAT C-262T C/C were defined as reference, those with CAT C-262T C/T demonstrated the OR for CKD of 0.67 (95% Cl 0.43-1.06) with the marginally significant trend for decreased odds ratio with increasing numbers of T allele (p = 0.070). There were no significant associations between the other polymorphisms with CKD risk. The present study found a marginally significant trend of the decreased risk of CKD with increasing numbers of T allele of CAT, which may suggest the possibility of personalized risk estimation of this life-limiting disease in the near future.
  • The association between the incidence of urolithiasis and nutrition based on Japanese National Health and Nutrition Surveys, Yasui T, Okada A, Hamamoto S, Hirose M, Ando R, Kubota Y, Tozawa K, Hayashi Y, Gao B, Suzuki S, Kohri K, Urolithiasis, 41, (3) 217 - 224,   2013年06月, 査読有り
  • MTHFR, MTR and MTRR polymorphisms and risk of chronic kidney disease in Japanese: cross-sectional data from the J-MICC Study., Asahi Hishida, Rieko Okada, Yin Guang, Mariko Naito, Kenji Wakai, Satoyo Hosono, Kazuyo Nakamura, Chowdhury Tanvir Turin, Sadao Suzuki, Hideshi Niimura, Haruo Mikami, Jun Otonari, Nagato Kuriyama, Sakurako Katsuura, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima, International Urology and Nephrology,   2013年04月18日, 査読有り, PURPOSE: Chronic kidney disease (CKD) is well known as a strong risk factor for both of end-stage renal disease and cardiovascular disease. To clarify the associations of MTHFR, MTR, and MTRR polymorphisms with the risk of CKD in Japanese, we examined this association among Japanese subjects using cross-sectional data. METHODS: The subjects for this analysis were 3,318 participants consecutively selected from the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. The polymorphisms were genotyped by a multiplex polymerase chain reaction-based Invader assay. Age- and sex-adjusted odds ratio (aOR) of CKD with stage 3-5 was calculated for each genotype. RESULTS: When those with MTHFR C677T C/C were defined as references, those with MTHFR C677T C/T and T/T demonstrated the aORs for CKD of 1.14 (95 % CI 0.93-1.40) and 1.39 (1.06-1.82), respectively. Marginally significantly decreased risk of CKD with increasing number of MTR A2756G G allele (p = 0.058) was observed. Stratified analyses by plasma folate low (<7.4 ng/ml) or high (?7.4 ng/ml) suggested significantly higher OR of CKD for those with MTHFR C677T T/T and low serum folate with the aOR of 2.07 (95 % CI 1.30-3.31) compared with that for those with MTHFR C677T T/T and high serum folate. CONCLUSIONS: The present study found a significant association between the subjects with the T/T genotype of MTHFR C677T polymorphism and the elevated risk of CKD, which may suggest the possibility of the risk evaluation and prevention of this potentially life-threatening disease based on genetic traits in the near future.
  • Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial, Hideki Ishikawa, Keiji Wakabayashi, Sadao Suzuki, Michihiro Mutoh, Keiji Hirata, Tomiyo Nakamura, Ikuko Takeyama, Atsuko Kawano, Nobuhisa Gondo, Takashi Abe, Shinkan Tokudome, Chiho Goto, Nariaki Matsuura, Toshiyuki Sakai, CANCER MEDICINE, 2, (1) 50 - 56,   2013年02月, 査読有り, There are several reports of clinical trials of aspirin in sporadic colon cancer. However, only one double-blind trial of aspirin in patients with familial adenomatous polyposis (FAP) has been reported to date. This double-blind, randomized, placebo-controlled clinical trial was therefore performed to evaluate the influence of low-dose aspirin enteric-coated tablets (100 mg/day for 610 months) in 34 subjects with FAP (17 each in the aspirin and placebo groups). The increase in mean diameter of colorectal polyps tended to be greater in the placebo group compared with the aspirin group, which showed a response ratio, that is, aspirin response rate (number of subjects with reduced polyps/total)/placebo response rate (number of subjects with reduced polyps/total), of 2.33 (95% confidence interval: 0.72-7.55). Subgroup analysis revealed that the number of subjects with a mean baseline polyp diameter of <= 2 mm, and the diameter and number of polyps after intervention showed a significant reduction in the aspirin group. Adverse effects of aspirin, such as anastomotic ulcer, aphtha in the large intestine, and progression of anemia, occurred in three subjects. Moreover, none of the subjects developed colorectal cancer. The results thus indicated a potential for aspirin to reduce colorectal adenoma development in patients with FAP, but careful follow-up is needed to avoid or rapidly counter severe adverse effects.
  • Significant interaction between RETN-420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese - the J-MICC Study, Asahi Hishida, Kenji Wakai, Rieko Okada, Emi Morita, Nobuyuki Hamajima, Satoyo Hosono, Yasuki Higaki, Tanvir Chowdhury Turin, Sadao Suzuki, Kheradmand Motahareh, Haruo Mikami, Naotaka Tashiro, Isao Watanabe, Sakurako Katsuura, Michiaki Kubo, Hideo Tanaka, Mariko Naito, ENDOCRINE JOURNAL, 60, (2) 237 - 243,   2013年02月, We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI >= 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI >= 25 (n = 10 for DM and 111 for non-DM), RETN-420 C/C+C/G and BMI < 25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI <25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95% confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required.
  • Significant interaction between RETN -420 G/G genotype and lower BMI on decreased risk of type 2 diabetes mellitus (T2DM) in Japanese--the J-MICC Study., Asahi Hishida, Kenji Wakai, Rieko Okada, Emi Morita, Nobuyuki Hamajima, Satoyo Hosono, Yasuki Higaki, Chowdhury Tanvir Turin, Sadao Suzuki, Kheradmand Motahareh, Haruo Mikami, Naotaka Tashiro, Isao Watanabe, Sakurako Katsuura, Michiaki Kubo, Hideo Tanaka, Mariko Naito, Endocrine Journal, Vol.60, (No.2) 237 - 243,   2013年01月18日, 査読有り, We examined the association of the RETN (resistin) -420 C>G polymorphism (rs1862513) with risk of diabetes mellitus (DM), considering lifestyle factors, in Japanese. Subjects were participants of J-MICC Study, where 2,651 participants aged 35-69 years provided their blood for genotyping and lifestyle data after informed consent. Odds ratio (OR) of DM for RETN-420 G/G genotype was estimated using unconditional logistic regression model. Statistically significant interaction on risk of DM was observed between RETN-420 G/G genotype and BMI<25 (OR for interaction = 0.12; P = 0.046), and when subjects with RETN-420 C/C+C/G and BMI 25 (n = 69 for DM and 544 for non-DM) were defined as the reference, the adjusted ORs for subjects with RETN-420 G/G genotype and BMI>25 (n = 10 for DM and 111 for non-DM), RETN-420 C/C+C/G and BMI<25 (n = 81 for DM and 1,605 for non-DM), and RETN-420 G/G and BMI<25 (n = 1 for DM and 230 for non-DM) were demonstrated to be 0.72 (95% confidence interval: 0.36-1.46), 0.40 (0.28-0.56) and 0.03 (0.005-0.25), respectively. The present study revealed the significant interaction of RETN-420 G/G genotype with lower BMI on the decreased risk of DM, but the direction was opposite to the reported ones in Japanese. We should be careful in interpretation of the present study results because of the limited sample sizes. Further investigation of this association as well as of the actual biological roles of RETN in the genesis of human metabolic disorders including DM will be required.
  • Increased protein stability of CDKN1C causes a gain-of-function phenotype in patients with IMAGe syndrome., Hamajima N, Johmura Y, Suzuki S, Nakanishi M, Saitoh S, PloS one, 8, (9) ,   2013年, 査読有り
  • Kidney stone formation is positively associated with conventional risk factors for coronary heart disease in Japanese men., Ando Ryosuke, Nagaya Teruo, Suzuki Sadao, Takahashi Hidekatsu, Kawai Makoto, Okada Atsushi, Yasui Takahiro, Kubota Yasue, Umemoto Yukihiro, Tozawa Keiichi, Kohri Kenjiro, The Journal of urology, 189, (4) 1340 - 6,   2013年
  • Japan Diabetes Outcome Intervention Trial-1 (J-DOIT1), a nationwide cluster randomized trial of type 2 diabetes prevention by telephone-delivered lifestyle support for high-risk subjects detected at health checkups: rationale, design, and recruitment, Naoki Sakane, Kazuhiko Kotani, Kaoru Takahashi, Yoshiko Sano, Kokoro Tsuzaki, Kentaro Okazaki, Juichi Sato, Sadao Suzuki, Satoshi Morita, Kazuo Izumi, Masayuki Kato, Naoki Ishizuka, Mitsuhiko Noda, Hideshi Kuzuya, BMC PUBLIC HEALTH, 13,   2013年01月, 査読有り, Background: Lifestyle modifications are considered the most effective means of delaying or preventing the development of type 2 diabetes (T2DM). To contain the growing population of T2DM, it is critical to clarify effective and efficient settings for intervention and modalities for intervention delivery with a wide population reach. The Japan Diabetes Outcome Intervention Trial-1 (J-DOIT1) is a cluster randomized controlled trial to test whether goal-focused lifestyle coaching delivered by telephone can prevent the development of T2DM in high-risk individuals in a real-world setting. This paper describes the study design and recruitment of the study subjects. Methods: For the recruitment of study subjects and their follow-up annually over 3 years, we employed health checkups conducted annually at communities and worksites. Health care divisions recruited from communities and companies across Japan formed groups as a cluster randomization unit. Candidates for the study, aged 20-65 years with fasting plasma glucose (FPG) of 5.6-6.9 mmol/l, were recruited from each group using health checkups results in 2006. Goal-focused lifestyle support is delivered by healthcare providers via telephone over a one-year period. Study subjects will be followed-up for three years by annual health checkups. Primary outcome is the development of diabetes defined as FPG >= 7.0 mmol/l on annual health checkup or based on self-report, which is confirmed by referring to medical cards. Results: Forty-three groups (clusters), formed from 17 health care divisions, were randomly assigned to an intervention arm (22 groups) or control arm (21 clusters) between March 2007 and February 2008. A total of 2840 participants, 1336 from the intervention and 1504 from the control arm, were recruited. Consent rate was about 20%, with no difference between the intervention and control arms. There were no differences in cluster size and characteristics of cluster between the groups. There were no differences in individual characteristics between the study arms. Conclusion: We have launched J-DOIT1, a nation-wide trial to prevent the development of T2DM in high-risk individuals using telephone-delivered intervention. This trial is expected to contribute to evidence-based real-world preventive practices.
  • Frequency of recurrent spontaneous abortion and its influence on further marital relationship and illness: the Okazaki Cohort Study in Japan., Mayumi Sugiura-Ogasawara, Sadao Suzuki, Yasuhiko Ozaki, Kinue Katano, Nobuhiro Suzumori, Tamao Kitaori, The journal of obstetrics and gynaecology research, 39, (1) 126 - 31,   2013年01月, 査読有り, AIMS: The aim of this study was to examine the influence of recurrent spontaneous abortion (RSA) on marital relationships, and the association between past/present illness and RSA. MATERIAL AND METHODS: A total of 2733 Japanese women who underwent a medical examination responded to the questionnaire. RESULTS: The frequency of recurrent miscarriage and two or more consecutive RSA were 0.88% and 4.2%, respectively. Women with a history of miscarriages (hazard ratio: 1.596) and RSA (hazard ratio: 3.103) were at a higher risk of their relationships ending as compared with the women without a history of miscarriage. Existence of a relation was seen between a history of RSA and the occurrence of gastric ulcer, gastritis, fatty liver, and atopic dermatitis. Overall, 89.5% of the women with RSA experienced cumulative live births. CONCLUSIONS:  Miscarriage was found to be a severe life event with an influence on marital relationships, and to be associated with an elevated risk of gastric disease or atopic dermatitis.
  • Polymorphisms in PPAR Genes (PPARD, PPARG, and PPARGC1A) and the Risk of Chronic Kidney Disease in Japanese: Cross-Sectional Data from the J-MICC Study, Hishida, Asahi, Wakai, Kenji, Naito, Mariko, Tamura, Takashi, Kawai, Sayo, Hamajima, Nobuyuki, Oze, Isao, Imaizumi, Takeshi, Turin, Tanvir Chowdhury, Suzuki, Sadao, Kheradmand, Motahare, Mikami, Haruo, Ohnaka, Keizo, Watanabe, Yoshiyuki, Arisawa, Kokichi, Kubo, Michiaki, Tanaka, Hideo, PPAR RESEARCH,   2013年
  • How to best phenotype the Broader Autism Phenotype (BAP) in Adults, Takeshi Nishiyama, Hirohisa Kishino, Kensuke Okada, Saeko Sakai, Yoko Kamio, Masako Suzuki, Katsunori Adachi, Satoshi Sumi, Masayo Kojima, Sadao Suzuki,   2012年11月, 査読有り
  • eNOS genotype modifies the effect of leisure-time physical activity on serum triglyceride levels in a Japanese population, Takahiro Higashibata, Nobuyuki Hamajima, Mariko Naito, Sayo Kawai, Guang Yin, Sadao Suzuki, Yoshikuni Kita, Hideshi Niimura, Takeshi Imaizumi, Keizo Ohnaka, Kokichi Arisawa, Masako Shigeta, Hidemi Ito, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Kenji Wakai, LIPIDS IN HEALTH AND DISEASE, 11,   2012年11月, Background: Nitric oxide is a key molecule not only in the cardiovascular system, but also in the metabolic-endocrine system. The purpose of this study was to examine possible associations of the NOS3 T-786C polymorphism (rs2070744) with serum lipid levels on the basis of lifestyle factors for tailoring prevention of dyslipidemia. Methods: For this cross-sectional study, a total of 2226 subjects aged 35 to 69 years (1084 men and 1142 women) were selected from Japanese participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. They were recruited in eight areas throughout Japan between February 2004 and November 2008. Results: In a stratified analysis by leisure-time physical activity, the likelihood of hypertriglyceridemia (serum triglyceride levels >= 150 mg/dL) among subjects with the C allele was significantly lower than those without it in the active group (OR = 0.43, 95% CI = 0.22-0.84 in the fasting group), but not in the sedentary group. A gene-environment interaction between the T-786C polymorphism and leisure-time physical activity for hypertriglyceridemia was significant (P = 0.007 in the fasting group). Additionally, serum triglyceride levels (mean +/- SD) across leisure-time physical activity classes decreased significantly only in the TC + CC genotype group (111 +/- 60 mg/dL for sedentary, 95 +/- 48 mg/dL for moderately active, 88 +/- 44 mg/dL for very active, P for trend = 0.008 in the fasting group), but not in the TT genotype group. Total cholesterol, high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol levels had no significant association with the polymorphism. Conclusions: This study suggests that the NOS3 T-786C polymorphism modifies the effect of leisure-time physical activity on serum triglyceride levels.
  • Effect of the PPARG2 Pro12Ala Polymorphism and Clinical Risk Factors for Diabetes Mellitus on HbA1c in the Japanese General Population, Megumi Hara, Yasuki Higaki, Naoto Taguchi, Koichi Shinchi, Emi Morita, Mariko Naito, Nobuyuki Hamajima, Naoyuki Takashima, Sadao Suzuki, Akihiko Nakamura, Keizo Ohnaka, Hirokazu Uemura, Hideki Nishida, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, JOURNAL OF EPIDEMIOLOGY, 22, (6) 523 - 531,   2012年11月, Background: Although the peroxisome proliferator-activated receptor-gamma 2 (PPARG2) Pro12Ala gene variant is associated with diabetes mellitus, the associations and interactions of this polymorphism and known clinical risk factors with glycated hemoglobin (HbA1c) remain poorly understood. We investigated if carrying the Ala allele was inversely associated with HbA1c level and examined possible interactions. Methods: This cross-sectional analysis used data collected from 1281 men and 1356 women aged 40 to 69 years who completed the baseline survey of the japan Multi-Institutional Collaborative Cohort Study. PPARG2 polymorphism was determined by multiplex polymerase chain reaction (PCR)-based Invader assay. Multiple linear regression and ANCOVA were used to control for confounding variables (age, body mass index [BMI], energy intake, alcohol, smoking, physical activity, and family history of diabetes) and examine possible interactions. Results: After adjustment, the Ala allele was significantly inversely associated with HbA1c in women but not in men. Older age, BMI, and family history of diabetes were associated with higher HbA1c in both sexes. When stratified by PPARG2 genotype, these associations were observed in subjects with the Pro12Pro genotype but not in Ala allele carriers. A significant interaction of genotype and BMI on HbA1c was observed in women. Older age, BMI, and family history of diabetes were significantly associated with high-normal HbA1c (>= 5.7% NGSP), whereas PPARG2 polymorphism was not. Conclusions: Although PPARG2 Pro12Ala polymorphism might attenuate associations between known risk factors and HbA1c level, it had a small effect on high-normal HbA1c, as compared with clinical risk factors, in the general population.
  • Associations of apolipoprotein A5 (APOA5), glucokinase (GCK) and glucokinase regulatory protein (GCKR) polymorphisms and lifestyle factors with the risk of dyslipidemia and dysglycemia in Japanese - a cross-sectional data from the J-MICC Study, Asahi Hishida, Emi Morita, Mariko Naito, Rieko Okada, Kenji Wakai, Keitaro Matsuo, Kazuyo Nakamura, Naoyuki Takashima, Sadao Suzuki, Toshiro Takezaki, Haruo Mikami, Keizo Ohnaka, Yoshiyuki Watanabe, Hirokazu Uemura, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima, ENDOCRINE JOURNAL, 59, (7) 589 - 599,   2012年07月, This study examined the associations of the APOA5 T-1131C (rs662799), G553T (Cys185Gly, rs2075291), GCK G-30A (rs1799884), GCKR A/G at intron 16 (rs780094) and T1403C (Leu446Pro, rs1260326) polymorphisms with scrum lipid and glucose levels in Japanese, considering lifestyle factors. Study subjects were 2,191 participants (aged 35-69 years, 1,159 males) enrolled in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. Dyslipidemia was defined as fasting serum triglycerides (FTG) >= 150 mg/dL and/or HDL-cholesterol (HDL-C) <40 mg/dL, while dysglycemia was as fasting blood sugar (FBS) >= 110 mg/dL. When those with APOA5 -1131 T/Tor 553 G/G were defined as references, those with APOA5 -1131 TIC, C/C or 553 G/T, T/T demonstrated significantly elevated risk of dyslipidemia (age- and sex-adjusted odds ratio: 1.77 [95% confidence interval:1.39-2.27], 3.35 [2.41-4.65], 2.23 [1.64-3.02] and 13.78 [3.44-55.18], respectively). Evaluation of FTG, HDL-C or FBS levels according to the genotype revealed that FIG and HDL-C levels were significantly associated with the APOA5T-1131C and G553Tpolymorphisms, FIG with the GCKR rs780094 and rs1260326 polyrnorphisms, and FBS with the GCICR rs780094 and rs1260326 polymorphisms. Moreover, a significant positive interaction between APOA5 553 G/T+T/T genotypes and fat intake >= 25% of total energy for the risk of dyslipidemia was observed. Our cross-sectional study confirmed the essential roles of the polymorphisms of the APOA5, GCK and GCKR in the lipid or glucose metabolism disorders, and suggested the importance of fat intake control in the individualized prevention of dyslipidemia.
  • Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity, Mineyoshi Hiyoshi, Hirokazu Uemura, Kokichi Arisawa, Mariko Nakamoto, Asahi Hishida, Rieko Okada, Keitaro Matsuo, Yoshikuni Kita, Hideshi Niimura, Nagato Kuriyama, Hinako Nanri, Keizo Ohnaka, Sadao Suzuki, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Nobuyuki Hamajima, GENE, 496, (2) 97 - 102,   2012年04月, 査読有り, In our previous proteomic study in rat liver damaged by carbon tetrachloride, soluble catechol-O-methyltransferase (COMT) increased as a phosphorylated form and decreased as a dephosphorylated form. This finding raised the possibility that the COMT protein is associated with liver function. Thus, we hypothesized that (1) the COMT gene contributes to liver homeostasis and (2) a COMT polymorphism (rs4680: Val158Met) causing thermolability of enzymatic activity affects liver enzymes (e.g., aspartate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (gamma-GT)) in serum. To investigate (2), we statistically analyzed the association between COMT genotypes and serum ALT activity in a cross-sectional study using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study. We conducted a multiple logistic regression analysis for males (n = 838) and females (n = 970). Those participants having missing values or a past history of liver cirrhosis or liver cancer were excluded. ALT values were divided into two; elevated (30 IU/L <=; males n = 239, females n = 90) and normal (<30 IU/L; males n = 599, females n = 880). In females, non-adjusted and adjusted odds ratios for ALT values in the rs4680 A/A homozygote (n = 126) compared with the wild-type G/G homozygote (n = 397) were 0.37 (95% CI 0.14-0.96) and 034 (95% CI 0.13-0.93), respectively. In males, an analysis of the population aged 35-69 did not reveal any significant difference, but the population aged 45-54 had a significant difference in the non-adjusted and adjusted odds ratio in the G/A heterozygote (n = 89) (0.50 (95% CI 0.27-0.92) and 0.35 (95% CI 0.18-0.71)) and in the A/A homozygote (n = 22) (0.34 (95% CI 0.11-0.99) and 0.22 (95% CI 0.07-0.72)), compared with the G/G homozygote (n = 88). These data suggest that the COMT polymorphism affects serum ALT activity to maintain liver function. (C) 2012 Elsevier B.V. All rights reserved.
  • Detailed Analysis of Japanese Population Substructure with a Focus on the Southwest Islands of Japan, Takeshi Nishiyama, Hirohisa Kishino, Sadao Suzuki, Ryosuke Ando, Hideshi Niimura, Hirokazu Uemura, Mikako Horita, Keizo Ohnaka, Nagato Kuriyama, Haruo Mikami, Naoyuki Takashima, Keitaro Mastuo, Yin Guang, Kenji Wakai, Nobuyuki Hamajima, Hideo Tanaka, PLOS ONE, 7, (4) ,   2012年04月, 査読有り, Uncovering population structure is important for properly conducting association studies and for examining the demographic history of a population. Here, we examined the Japanese population substructure using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC), which covers all but the northern region of Japan. Using 222 autosomal loci from 4502 subjects, we investigated population substructure by estimating FST among populations, testing population differentiation, and performing principal component analysis (PCA) and correspondence analysis (CA). All analyses revealed a low but significant differentiation between the Amami Islanders and the mainland Japanese population. Furthermore, we examined the genetic differentiation between the mainland population, Amami Islanders and Okinawa Islanders using six loci included in both the Pan-Asian SNP (PASNP) consortium data and the J-MICC data. This analysis revealed that the Amami and Okinawa Islanders were differentiated from the mainland population. In conclusion, we revealed a low but significant level of genetic differentiation between the mainland population and populations in or to the south of the Amami Islands, although genetic variation between both populations might be clinal. Therefore, the possibility of population stratification must be considered when enrolling the islander population of this area, such as in the J-MICC study.
  • Gene variants in PPARD and PPARGC1A are associated with timing of natural menopause in the general Japanese population, Hirokazu Uemura, Mineyoshi Hiyoshi, Kokichi Arisawa, Miwa Yamaguchi, Mariko Naito, Sayo Kawai, Nobuyuki Hamajima, Keitaro Matsuo, Naoto Taguchi, Naoyuki Takashima, Sadao Suzuki, Kazuyo Hirasada, Haruo Mikami, Keizo Ohnaka, Aya Yoshikawa, Michiaki Kubo, Hideo Tanaka, MATURITAS, 71, (4) 369 - 375,   2012年04月, Objectives: Timing of menopause affects postmenopausal health risks. The objective of this study was to evaluate the associations of the single nucleotide polymorphisms (SNPs) in peroxisome proliferator-activated receptor (PPAR)-related genes (PPARD, PPARG, and PPARGC1A) and environmental factors with timing of natural menopause among the general Japanese population. Study design: We analyzed cross-sectional data from 1758 women aged 40-69 years who were enrolled in the baseline surveys of the Japan Multi-institutional Collaborative Cohort (J-MICC) Study. Main outcome measures: Associations of timing of natural menopause with its probable covariates and with target gene variants were evaluated by univariate and multivariate Cox proportional hazards models. Results: Lower body mass index and later age at menarche were significantly associated with earlier natural menopause. Women with minor alleles at T-48444C in PPARD showed a significantly higher adjusted hazard ratio of 1.57 (95% confidence interval: 1.18-2.10) for earlier natural menopause. In contrast, women with minor alleles at Thr394Thr in PPARGC1A showed a significantly lower adjusted hazard ratio of 0.86 (0.76-0.97) for earlier natural menopause. These associations did not substantially alter when re-analyzed after excluding the subjects who self-reported a history of diabetes or the subjects whose age was more than 65 years. Conclusions: Gene variants in PPARD and PPARGC1A might be associated with timing of natural menopause, probably through direct actions on the ovaries, among the general Japanese population. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
  • Matrix Metalloproteinase-9 Gene Polymorphisms and Chronic Kidney Disease, Rieko Okada, Sayo Kawai, Mariko Naito, Asahi Hishida, Nobuyuki Hamajima, Koichi Shinchi, Tanvir Chowdhury Turin, Sadao Suzuki, Eva Mariane Mantjoro, Kengo Toyomura, Kokichi Arisawa, Nagato Kuriyama, Satoyo Hosono, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, Kenji Wakai, AMERICAN JOURNAL OF NEPHROLOGY, 36, (5) 444 - 450,   2012年, Background: The aim of this study was to explore the associations between the prevalence of chronic kidney disease (CKD) and polymorphisms in the genes encoding matrix metalloproteinases (MMPs) and tissue inhibitor of matrix metalloproteinases (TIMPs). MMPs degrade extracellular matrix proteins in the glomerulus, and play important roles in kidney disease progression. Methods: DNA samples from 3,309 subjects aged 35-69 years were genotyped for 10 potentially functional polymorphisms in MMP and TIMP genes. The prevalence of CKD (estimated glomerular filtration rate ! 60 ml/min/1.73 m(2)) was compared among the genotypes. Results: The prevalence of CKD decreased significantly with the number of minor alleles in MMP9 C-1562T (odds ratios (ORs) 0.77 for CT and 0.65 for TT compared with CC; p for trend = 0.023) and MMP9 R668Q (ORs, 0.79 for RQ and 0.64 for QQ compared with RR; p for trend = 0.024). The haplotype MMP9 -1562T/279R/668Q showed a reduced risk for CKD compared with the most common -1562C/279R/668R (OR 0.77, p = 0.008), and the genotype combination -1562TT/279RR/668QQ showed a halved risk for CKD compared with major allele homozygous -1562CC/279RR/668RR (OR 0.53, p = 0.091). Conclusion: The potentially functional polymorphisms of MMP9 were associated with the prevalence of CKD in a large Japanese population. These genotypes have been reported to increase MMP9 expression, supporting the hypothesis that MMP-9 has a protective role in the progression of kidney diseases. Copyright (C) 2012 S. Karger AG, Basel
  • Pro-/anti-inflammatory cytokine gene polymorphisms and chronic kidney disease: a cross-sectional study, Rieko Okada, Kenji Wakai, Mariko Naito, Emi Morita, Sayo Kawai, Nobuyuki Hamajima, Megumi Hara, Naoyuki Takashima, Sadao Suzuki, Toshiro Takezaki, Keizo Ohnaka, Kokichi Arisawa, Hiroshi Hirohata, Keitaro Matsuo, Haruo Mikami, Michiaki Kubo, Hideo Tanaka, BMC NEPHROLOGY, 13,   2012年01月, Background: The aim of this study was to explore the associations between common potential functional promoter polymorphisms in pro-/anti-inflammatory cytokine genes and kidney function/chronic kidney disease (CKD) prevalence in a large Japanese population. Methods: A total of 3,323 subjects aged 35-69 were genotyped for all 10 single nucleotide polymorphisms (SNPs) in the promoter regions of candidate genes with minor allele frequencies of > 0.100 in Japanese populations. The estimated glomerular filtration rate (eGFR) and CKD prevalence (eGFR < 60 ml/min/1.73 m(2)) of the subjects were compared among the genotypes. Results: A higher eGFR and lower prevalence of CKD were observed for the homozygous variants of IL4 -33CC (high IL-4 [anti-inflammatory cytokine]-producing genotype) and IL6 -572GG (low IL-6 [pro-inflammatory cytokine]producing genotype). Subjects with IL4 CC + IL6 GG showed the highest mean eGFR (79.1 ml/min/1.73 m(2)) and lowest CKD prevalence (0.0%), while subjects carrying IL4 TT + IL6 CC showed the lowest mean eGFR (73.4 ml/min/1.73 m(2)) and highest CKD prevalence (17.9%). Conclusions: The functional promoter polymorphisms IL4 T-33C (rs2070874) and IL6 C-572G (rs1800796), which are the only SNPs that affect the IL-4 and IL-6 levels in Japanese subjects, were associated with kidney function and CKD prevalence in a large Japanese population.
  • Impact of insulin resistance, insulin and adiponectin on kidney stones in the Japanese population, Ryosuke Ando, Sadao Suzuki, Teruo Nagaya, Tamaki Yamada, Atsushi Okada, Takahiro Yasui, Keiichi Tozawa, Shinkan Tokudome, Kenjiro Kohri, INTERNATIONAL JOURNAL OF UROLOGY, 18, (2) 131 - 138,   2011年02月, 査読有り, Objectives: It has been reported that kidney stones are linked to metabolic syndrome (MetS), which is characterized by insulin resistance. The aim of the present study was to examine the association of insulin resistance, insulin and adiponectin with kidney stones in a Japanese population. Methods: From February 2007 to March 2008, 1036 (529 men and 507 women) apparently healthy Japanese subjects, aged 35-79 years, were analyzed. Weight, height, waist circumference and blood pressure were measured. Overnight fasting blood was collected to measure insulin and adiponectin levels. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated to assess insulin resistance. Logistic regression analysis was used to estimate the odds ratio (OR) and 95% confidence intervals for a self-reported history of kidney stones across tertiles of HOMA-IR, insulin and adiponectin. Results: Of the participants, 84 men (15.6%) and 35 women (6.9%) had a history of kidney stones. Age, body mass index, waist circumference, systolic and diastolic blood pressures, HOMA-IR and insulin were significantly higher in women with than in women without kidney stones. There was no difference in adiponectin level between subjects with and without a history of kidney stones in either sex. Furthermore, a significant positive trend was observed in the age-adjusted OR for a history of kidney stones across insulin tertiles (P-value for trend = 0.04) in women. Conclusions: For Japanese women, HOMA-IR and insulin are associated with a history of kidney stones. The findings suggest that MetS components could increase the risk of kidney stones through subclinical hyperinsulinemia and insulin resistance.
  • Interest in health screening as a predictor of long-term overall mortality: Multilevel analysis of a Japanese national cohort study, Yoshihisa Fujino, Naohito Tanabe, Kaori Honjo, Sadao Suzuki, Hiroyasu Iso, Akiko Tamakoshi, PREVENTIVE MEDICINE, 52, (1) 78 - 83,   2011年01月, 査読有り, Background. In Japan, screening programmes have been widely implemented as a public health practice. We investigated the effect of the area-level interest in health screening on mortality using data from a large cohort in Japan. Methods. A baseline survey was conducted between 1988 and 1990 among 110,792 residents of 45 areas, aged 40-79 years. Area-level interest in health screening was defined as the proportion of people with high and moderate interest in health screening in an area. Multilevel Poisson regression was employed in a two-level structure of individuals nested within the areas. During 15 years of follow-up (1,035,617 person-years), 13,184 deaths were observed. Results. The reduction in mortality rate was (a) 2% in both men (p = 0.009) and women (p = 0.038) for each percent increase in area-level interest in screening, and (b) 10% in men (p = 0.001) and 9% in women (p = 0.001) for individual attendance to screening in the year before follow-up. There was no interaction between area-level interest in screening, individual-level attendance at screening and overall mortality. Conclusion. Area-level and individual interest for health screening appear to be independent predictor of 15-year mortality in this national Japanese study. The present findings may support public health practices to promote knowledge and participation in screening programmes. (c) 2010 Elsevier Inc. All rights reserved.
  • Body mass index and all-cause mortality among Japanese older adults: findings from the Japan Collaborative Cohort Study, TAMAKOSHI Akiko, YATSUYA Hiroshi, LIN Yingsong, TAMAKOSHI Koji, KONDO Takaaki, SUZUKI Sadao, YAGYU Kiyoko, KIKUCHI Shogo, Obesity, 18, (2) ,   2010年02月, 査読有り, 65歳以上の日本人高齢者27,000人を対象に行ったコホート集団の平均11年にわたる追跡調査の結果,高齢者では過体重よりも低体重が全死亡に強く関連していることを明らかにした。
  • Live birth rate according to maternal age and previous number of recurrent miscarriages., Mayumi Sugiura-Ogasawara, Yasuhiko Ozaki, Tamao Kitaori, Nobuhiro Suzumori, Shintaro Obayashi, Sadao Suzuki, American journal of reproductive immunology (New York, N.Y. : 1989), 62, (5) 314 - 9,   2009年11月, 査読有り, PROBLEM: In Japan, marital age and women's age at the first pregnancy are continuing to increase year by year. However, information concerning subsequent live birth rate according to maternal age and number of previous recurrent miscarriages is limited. METHOD OF STUDY: We studied a total of 1250 unexplained patients suffering two or more consecutive miscarriages. We examined the live birth rate at the first pregnancy and the cumulative success rate for birth of at least one child after examination. RESULTS: The live birth rate of women in their 40s was 58.1%, which was similar to that of women who were 35-39 years old (58.4%) at the first pregnancy, as found after examination. From logistic regression, women's age and the number of previous miscarriages independently decreased the live birth rate in subsequent pregnancies (p(s)) as well as cumulative pregnancies (p(c)), as follows: logit (p(s)) = 3.964 - 0.0652 x (age) - 0.408 x (previous number of miscarriages), logit(p(c)) = 6.806 - 0.1130 x (age) - 0.514 x (previous number of miscarriages). CONCLUSION: The information concerning the live birth rate can be given to each patient before subsequent pregnancy.
  • Parental Smoking and Smoking Status of Japanese Dental Hygiene Students: A Pilot Survey at a Dental Hygiene School in Japan, Toru Naito, Koichi Miyaki, Mariko Naito, Masahiro Yoneda, Nao Suzuki, Takao Hirofuji, Takeo Nakayama, INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 6, (1) 321 - 328,   2009年01月, 査読有り, This study aimed to determine the frequency of smoking and to explore factors associated with the smoking habits of female students at a dental hygiene school in Japan. Questionnaires regarding cigarette smoking were given to 168 female students. The response rate was 97.6%. The prevalence of smoking, including current and occasional smokers, was 20.3%. Among family members, only the smoking status of their mother significantly influenced the smoking status of the students. The odds ratio for smoking among dental hygiene students whose mothers were smokers in comparison to students whose mothers were not smokers was 5.1 (95% confidence interval 2.1-12.2, p=0.000). Decision tree analysis showed that the smoking habit of dental hygiene students was correlated with their mothers' smoking history, as well as the smoking status of junior high school teachers, the smoking habits of close friends and a history of participating in a smoking prevention program when in elementary school. The increased smoking rate of young females, including dental hygienists, is a growing problem in Japan. The smoking statuses of dental hygiene students might be closely influenced by their mothers' smoking status.
  • Serum insulin-like growth factors I and II, insulin-like growth factor binding protein-3 and risk of breast cancer in the Japan Collaborative Cohort study, Sakauchi F, Nojima M, Mori M, Wakai K, Suzuki S, Tamakoshi A, Ito Y, Watanabe Y, Inaba Y, Tajima K, Nakachi K, Asian Pac J Cancer Prev, 10 Suppl, 51 - 55,   2009年, 査読有り
  • Prevalence and epidemiological characteristics of lower urinary tract stones in Japan, Takahiro Yasui, Masanori Iguchi, Sadao Suzuki, Atsushi Okada, Yasunori Itoh, Keiichi Tozawa, Kenjiro Kohri, Urology, 72, (5) 1001 - 1005,   2008年11月, 査読有り
  • Inverse relationship between obesity and serum prostate-specific antigen level in healthy Japanese men: a hospital-based cross-sectional survey, 2004-2006., Ando R, Nagaya T, Hashimoto Y, Suzuki S, Itoh Y, Umemoto Y, Ikeda N, Tozawa K, Kohri K, Tokudome S, Urology, 72, (3) 561 - 565,   2008年09月, 査読有り
  • Prevalence and epidemiological characteristics of urolithiasis in Japan: national trends between 1965 and 2005., Yasui T, Iguchi M, Suzuki S, Kohri K, Urology, 71, (2) 209 - 213,   2008年02月, 査読有り
  • Eicosapentaenoic acid has a preventive effect to the recurrence of nephrolithiasis., Takahiro Yasui, Sadao Suzuki, Yasunori Itoh, Keiichi Tozawa, Shinkan Tokudome, Kenjiro Kohri, Urologia Internationalis, 81, (2) 135 - 138,   2008年, 査読有り
  • Serum concentrations of fatty acids and colorectal adenoma risk: a case-control study in Japan., Ghadimi R, Kuriki K, Tsuge S, Takeda E, Imaeda N, Suzuki S, Sawai A, Takekuma K, Hosono A, Tokudome Y, Goto C, Esfandiary I, Nomura H, Tokudome S, Asian Pacific journal of cancer prevention : APJCP, 9, 111 - 118,   2008年01月, 査読有り
  • Consumption of soy foods and the risk of breast cancer: findings from the Japan Collaborative Cohort (JACC) Study, Kazuko Nishio, Yoshimitsu Niwa, Hideaki Toyoshima, Koji Tamakoshi, Takaaki Kondo, Hiroshi Yatsuya, Akio Yamamoto, Sadao Suzuki, Shinkan Tokudome, Yingsong Lin, Kenji Wakai, Nobuyuki Hamajima, Akiko Tamakoshi, CANCER CAUSES & CONTROL, 18, (8) 801 - 808,   2007年10月, 査読有り, Objective The association between a lower incidence of breast cancer within the Asian population and the consumption of a diet high in soy has recently been the subject of much attention. To examine whether soy foods really have protective effects against breast cancer and how their influence on breast cancer is modified according to menopausal status, we conducted a population-based, prospective cohort study in Japan. Methods We analyzed the data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 30,454 women aged 40-79 years, completed a questionnaire on diet and other lifestyle features. Hazard ratios (HRs) were computed to examine the association between soy intake and the risk of breast cancer. Results During the mean follow-up of 7.6 years, 145 cases of breast cancer were documented. We found no significant association between the risk of breast cancer and consumption of tofu, boiled beans, and miso soup; the multivariate HRs (95% CI) in the highest category of consumption were 1.14 (0.74-1.77), 0.77 (0.47-1.27) and 1.01 (0.65-1.56), respectively. Only among postmenopausal women, we found no significant associations between soy foods and the risk of breast cancer. Conclusions This prospective study suggests that consumption of soy food has no protective effects against breast cancer. Further large-scale investigations eliciting genetic factors may clarify different roles of various soybean-ingredient foods on the risk of breast cancer.
  • Independent associations of alexithymia and social support with depression in hemodialysis patients, Masayo Kojima, Junichiro Hayano, Shinkan Tokudome, Sadao Suzuki, Koichi Ibuki, Hiroshi Tomizawa, Atsuro Nakata, Hachiro Seno, Takanobu Toriyama, Hiroshi Kawahara, Toshiaki A. Furukawa, JOURNAL OF PSYCHOSOMATIC RESEARCH, 63, (4) 349 - 356,   2007年10月, 査読有り, Objective: The influences of alexithymia and social support on depression among chronically ill patients were examined prospectively. Methods: The study population was 230 outpatients receiving chronic hemodialysis (HD) therapy. The Beck Depression Inventory-II (BDI-II), the 20-item Toronto Alexithymia Scale (TAS-20), and two subscales of the Social Support Questionnaire were given to the subjects. The BDI-II was readministered after a 6-month interval, and subjects who showed deterioration in their depression score above the level predicted from their baseline score were identified. Multivariate logistic analysis adjusted for age, gender, cause of dialysis, and psychosocial variables were performed. Results: Baseline depression was significantly and independently associated with alexithymia and low satisfaction with available support. Deterioration of depression after 6 months was predicted by alexithymia and poor available support. Conclusions: Alexithymia and reduced social support might have independent associations with the presence and the prognosis of depression among HD patients. (c) 2007 Elsevier Inc. All rights reserved.
  • Liver cancer risk, coffee, and hepatitis C virus infection: a nested case-control study in Japan, K. Wakai, Y. Kurozawa, A. Shibata, Y. Fujita, K. Kotani, I. Ogimoto, M. Naito, K. Nishio, H. Suzuki, T. Yoshimura, A. Tamakoshi, BRITISH JOURNAL OF CANCER, 97, (3) 426 - 428,   2007年07月, We examined hepatocellular carcinoma mortality in relation to coffee consumption and anti- hepatitis C virus ( HCV) antibody seropositivity in a nested case - control study involving 96 cases. The multivariate- adjusted odds ratios ( 95% confidence interval) for daily coffee drinkers vs non- drinkers were 0.49 ( 0.25 - 0.96), 0.31 ( 0.11 - 0.85), and 0.75 ( 0.29 - 1.92) in all cases, in HCV- positive and in HCV- negative individuals, respectively.
  • Influence of smoking and CYP2C19 genotypes on H-pylori eradication success, T. Suzuki, K. Matsuo, A. Sawaki, K. Wakai, K. Hirose, H. Ito, T. Saito, T. Nakamura, K. Yamao, N. Hamajima, K. Tajima, EPIDEMIOLOGY AND INFECTION, 135, (1) 171 - 176,   2007年01月, 査読有り, CYP2C19 polymorphisms and smoking influence the efficacy of H. pylori eradication therapy, but interaction between the two have hitherto not been examined. A total of 142 H. pylori-positive patients who received triple drug therapy with lansoprazole, amoxicillin and clarithromycin were categorized into three groups with regard to diplotypes of CYP2C19: homozygous extensive metabolizer (homEM), heterozygous EM (hetEM), and poor metabolizer (PM). The overall success rate was 61 center dot 3%. Smoking was an independent risk factor of eradication failure (OR 2 center dot 81, 95% CI 1 center dot 14-6 center dot 91), whereas CYP2C19 polymorphisms were less influential. Among non-smokers, the homEM and hetEM groups showed worse eradication rates (58 center dot 5 and 67 center dot 3%) relative to PM (76 center dot 2%) as expected; however, an opposite trend was observed among smokers (homEM 50-0%, hetEM 46 center dot 7%, PM 20 center dot 0%), indicating possible interactions with CYP2C19 polymorphisms. Smoking has a greater influence on H. pylori eradication than the CYP2C19 genotype. Interaction between smoking and CYP2C19 should be examined in the future.
  • Dietary habits and risk of ovarian cancer death in a large-scale cohort study (JACC study) in Japan, Fumio Sakauchi, M. M. H. Khan, Mitsuru Mori, Tatsuhiko Kubo, Yoshihisa Fujino, Sadao Suzuki, Shinkan Tokudome, Akiko Tamakoshi, NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 57, (2) 138 - 145,   2007年, 査読有り, The Japan Collaborative Cohort (JACC) Study was established in 1988-1990 and consisted of 46,465 men and 64,327 women observed until the end of 2003. A self-administered food frequency questionnaire was used as a baseline survey, and associations of dietary habits with the risk of ovarian cancer death were evaluated, taking into consideration age, menstrual and reproductive, anthropometric, and lifestyle factors. During the observation period, 77 women died of ovarian cancer. Hazard ratios for dietary factors were calculated by Cox's proportional hazards model. Being adjusted only for age, high intakes of dried or salted fish and Chinese cabbage were positively associated with the risk of ovarian cancer death, and the risk increased dose-dependently. In contrast, intake of soybean curd (tofu) was inversely associated with the risk. After being adjusted for age and potential confounding factors, the results regarding the intakes of dried or salted fish and Chinese cabbage did not change. However, the significance relating to the intake of soybean curd (tofu) was attenuated. Front the results of this cohort study, it was suggested that high intakes of dried or salted fish and Chinese cabbage were potential risk factors of ovarian cancer death. In contrast, however, a high intake of soy bean curd (tofu) might have preventive effects against the risk.
  • 日本人における喫煙と卵巣癌罹患リスクの関連, 丹羽 慶光, 若井 建志, 鈴木 貞夫, 玉腰 浩司, 林 櫻松, 八谷 寛, 近藤 高明, 西尾 和子, 山本 昭夫, 徳留 信寛, 豊島 英明, 玉腰 暁子, 東海産科婦人科学会雑誌, 43, 208 - 208,   2006年12月01日
  • Helicobacter pylori infection appears the prime risk factor for stomach cancer, Shinkan Tokudome, Reza Ghadimi, Sadao Suzuki, Akihiro Hosono, Tsutomu Tanaka, Kazuyuki Arakawa, Yang Zhao, Nami Hattori, Hiroyuki Agawa, Mitsuhiro Marumoto, Ryosuke Ando, Malcolm A. Moore, INTERNATIONAL JOURNAL OF CANCER, 119, (12) 2991 - 2991,   2006年12月, 査読有り
  • Effectiveness of cervical cancer screening over cervical cancer mortality among Japanese women, Khandoker Aklimunnessa, Mitsuru Mori, M. M. H. Khan, Fumio Sakauchi, Tatsuhiko Kubo, Yoshihisa Fujino, Sadao Suzuki, Shinkan Tokudome, Akiko Tamakoshi, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 36, (8) 511 - 518,   2006年08月, 査読有り, Background: Various studies have revealed that cervical cancer (CC) screening significantly reduces both CC incidence and mortality in developed countries. Although Japan introduced a nationwide government funded annual CC screening for the women aged 30+ in 1982, the effectiveness of CC screening on CC mortality has not yet been evaluated by any prospective cohort study. Therefore, the present study evaluated the association of CC mortality with self-reported CC screening and some other factors by a nationwide cohort study. Methods: Baseline survey of the Japan Collaborative Cohort Study for the enrollment of subjects was completed during 1988-90 and followed until 2003. This study only analyzed 63 541 women, aged 30-79 years, who were free from any cancer history at enrollment. Results: During the follow-up period, 38 CC deaths were identified. The mean age at mortality was 67.0 years, with a mortality rate of 4.2 per 100 000 person-years. Participation rate in CC screening was 46.9%. Age-adjusted Cox model indicated significantly lower CC mortality [hazard ratio (HR) = 0.30, 95% confidence interval (CI) = 0.12-0.74] due to CC screening. Protectiveness remained almost the same (HR = 0.30, 95% CI = 0.12-0.76) when adjusted for age, body mass index and number of deliveries. The results also revealed that CC screening could reduce at least 50% of CC deaths even after excluding the effect of possible self-selection bias. Conclusions: CC screening in Japan may reduce CC mortality significantly for women aged 30-79 years. However, further studies with more CC deaths and increased statistical power are needed to validate the findings.
  • Alcohol consumption and lung cancer mortality in Japanese men: Results from Japan Collaborative Cohort (JACC) Study, Y Nishino, K Wakai, T Kondo, N Seki, Y Itos, K Suzuki, K Ozasa, Y Watanabe, M Ando, Y Tsubono, Tsuji, I, A Tamakoshi, JOURNAL OF EPIDEMIOLOGY, 16, (2) 49 - 56,   2006年03月, 査読有り, BACKGROUND: The relationship between alcohol consumption and increased risk of lung cancer is controversial. This study was set up to investigate the association between alcohol consumption and death from lung cancer in a large Japanese cohort. METHODS: The subjects comprised 28,536 males, aged 40-79 years, living throughout Japan. During 268,464 person-years of follow-up, 377 lung cancer deaths were recorded. The hazard ratio (HR) of alcohol consumption for lung cancer mortality was calculated using the Cox proportional hazards model after adjustment for age, smoking and family history of lung cancer. RESULTS: There was no association between increased mortality from lung cancer and alcohol consumption among current drinkers. Compared with subjects who had never drunk alcohol, the HRs (95% confidence interval [CI]) of death from lung cancer for light (consuming < 25.0 g ethanol per day), moderate (25.0-49.9 g per day) and heavy (>= 50 g per day) drinkers were 0.81 (95% CI=0.61-1.07), 0.82 (0.61-1.11) and 0.97 (0.66-1.43), respectively. Further adjustment for fruit and vegetable intake did not change the results, and there was no change in HR materially after excluding those patients who died during the first 5 years of follow-up. CONCLUSIONS: These findings indicate that alcohol consumption was not associated with increased lung cancer mortality in this population of Japanese men.
  • Marine n-3 fatty acids and colorectal cancer: is there a real link?, Tokudome S, Kojima M, Suzuki S, Ichikawa H, Ichikawa Y, Miyata M, Maeda K, Marumoto M, Agawa H, Arakawa K, Tanaka T, Ando R, Hattori N, Goto C, Tokudome Y, Imaeda N, Kuriki K, Okuyama H, Moore MA, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15, 406 - 407,   2006年02月, 査読有り
  • Helicobacter pylori infection as an essential factor for stomach cancer., Tokudome S, Hosono A, Suzuki S, Ghadimi R, Tanaka T, Ichikawa H, Miyata M, Marumoto M, Agawa H, Arakawa K, Ando R, Hattori N, Shibata K, Yang Z, Asian Pacific journal of cancer prevention : APJCP, 7, (1) ,   2006年01月, 査読有り
  • Risk of endometrial cancer mortality by ever-use of sex hormones and other factors in Japan, Khan M.M.H, Mori M, Sakauchi F, Aklimunnessa K, Kubo T, Fujino Y, Suzuki S, Tokudome S, Tamakoshi A, Motohashi Y, Tsuji I, Nakamura Y, Iso H, Mikami H, Inaba Y, Hoshiyama Y, Suzuki H, Shimizu H, Toyoshima H, Wakai K, Ito Y, Hashimoto S, Kikuchi S, Koizumi A, Kawamura T, Watanabe Y, Miki T, Date C, Sakata K, Nose T, Hayakawa N, Yoshimura T, Shibata A, Okamoto N, Shio H, Ohno Y, Kitagawa T, Kuroki T, Tajima K, Shimamoto T, Tanaka H, Hisamichi S, Nakao M, Suzuki T, Hashimoto T, Ishibashi T, Fukuda K, Asian Pacific Journal of Cancer Prevention, 7, (2) 260 - 266,   2006年, 査読有り
  • Dietary intakes of fat and fatty acids and risk of breast cancer: A prospective study in Japan, K Wakai, K Tamakoshi, C Date, M Fukui, S Suzuki, YS Lin, Y Niwa, K Nishio, H Yatsuya, T Kondo, S Tokudome, A Yamamoto, H Toyoshima, A Tamakoshi, CANCER SCIENCE, 96, (9) 590 - 599,   2005年09月, 査読有り, To examine the possible association of dietary fat and fatty acids with breast cancer risk in a population with a low total fat intake and a high consumption of fish, we analyzed data from the Japan Collaborative Cohort (JACC) Study. From 1988 to 1990, 26 291 women aged 40-79 years completed a questionnaire on dietary and other factors. Intakes of fat or fatty acids were estimated by using a food frequency questionnaire. Rate ratios (RR) were computed by fitting proportional hazards models. During the mean follow-up of 7.6 years, 129 breast cancer cases were documented. We found no clear association of total fat intake with breast cancer risk; the multivariate-adjusted RR across quartiles were 1.00, 1.29, 0.95, and 0.80 (95% confidence interval [CI] 0.46-1.38). A significant decrease in the risk was detected for the highest quartile of intake compared with the lowest for fish fat and long-chain n-3 fatty acids; the RR were 0.56 (95% Cl 0.330.94) and 0.50 (0.30-0.85), respectively. A decreasing trend in risk was also suggested with an increasing intake of saturated fatty acids (trend P = 0.066). Among postmenopausal women at baseline, the highest quartile of vegetable fat intake was associated with a 2.08-fold increase in risk (95% Cl 1.05-4.13). This prospective study did not support any increase in the risk of breast cancer associated with total or saturated fat intake, but it suggested the protective effects of the long-chain n-3 fatty acids that are abundant in fish.
  • Plasma carotenoid, alpha-tocopherol and retinol concentrations and risk of colorectal adenomas: A case-control study in Japan, J Jiang, S Suzuki, J Xiang, K Kuriki, A Hosono, K Arakawa, JW Wang, T Nagaya, M Kojima, N Katsuda, S Tokudome, CANCER LETTERS, 226, (2) 133 - 141,   2005年08月, 査読有り, To investigate associations between plasma carotenoids, alpha-tocopherol and retinol with colorectal adenomas risk, we measured concentrations in 224 asymptomatic colorectal adenoma cases and 230 population-based controls matched for age and sex. After adjustment for age, history of colorectal adenomas and cancers, BMI, smoking, drinking status, multivitamin consumption and plasma total cholesterol, the risk of colorectal adenomas in the highest quartile was approximately half of that of men in the lowest quartile for a-carotene (OR=0.38; 95% CI: 0.18-0.84; P(trend =)0.01), beta-carotene (OR=0.51; 95% CI: 0.24-1.07; P-trend=0.03) and total carotenoids (OR=0.48; 95% CI: 0.22-1.03; P-trend=0.04). In addition, a protective association for a-carotene in women was also indicated, but which did not reach statistical significance (OR=0.53; 95% CI: 0.19-1.52; P-trend=0.35). Our findings suggest a protective effect of carotenoids against the development of colorectal adenomas. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
  • Leptin is associated with increased female colorectal cancer risk: A nested case-control study in Japan, Tamakoshi K, Toyoshima H, Wakai K, Kojima M, Suzuki K, Watanabe Y, Hayakawa N, Yatsuya H, Kondo T, Tokudome S, Hashimoto S, Suzuki S, Kawado M, Ozasa K, Ito Y, Tamakoshi A for, the JACC, Study Group, Oncology, 68, (4-6) ,   2005年07月14日, 査読有り
  • Medical history of circulatory diseases and colorectal cancer death in the JACC Study., Watanabe Y, Ozasa K, Ito Y, Suzuki K, Kojima M, Suzuki S, Tokudome S, Tamakoshi K, Toyoshima H, Kawado M, Hashimoto S, Hayakawa N, Wakai K, Tamakoshi A, JACC Study Group, Journal of epidemiology / Japan Epidemiological Association, 15 Suppl 2, S168 - 72,   2005年06月, 査読有り
  • Alcohol consumption and colorectal cancer risk: findings from the JACC Study., Wakai K, Kojima M, Tamakoshi K, Watanabe Y, Hayakawa N, Suzuki K, Hashimoto S, Kawado M, Tokudome S, Suzuki S, Ozasa K, Toyoshima H, Ito Y, Tamakoshi A, JACC Study Group, Journal of epidemiology / Japan Epidemiological Association, 15 Suppl 2, S173 - 9,   2005年06月, 査読有り
  • Glucose intolerance and colorectal cancer risk in a nested case-control study among Japanese People., Ozasa K, Ito Y, Suzuki K, Watanabe Y, Kojima M, Suzuki S, Tokudome S, Tamakoshi K, Toyoshima H, Kawado M, Hashimoto S, Hayakawa N, Wakai K, Tamakoshi A, JACC Study Group, Journal of epidemiology / Japan Epidemiological Association, 15 Suppl 2, S180 - 4,   2005年06月, 査読有り
  • Colorectal cancer and serum C-reactive protein levels: a case-control study nested in the JACC Study., Ito Y, Suzuki K, Tamakoshi K, Wakai K, Kojima M, Ozasa K, Watanabe Y, Kawado M, Hashimoto S, Suzuki S, Tokudome S, Toyoshima H, Hayakawa N, Kato K, Watanabe M, Ohta Y, Maruta M, Tamakoshi A, JACC Study Group, Journal of epidemiology / Japan Epidemiological Association, 15 Suppl 2, S185 - 9,   2005年06月, 査読有り
  • Serum carotenoids and other antioxidative substances associated with urothelial cancer risk in a nested case-control study in Japanese men, K Ozasa, Y Ito, K Suzuki, Y Watanabe, K Hayashi, K Mikami, M Nakao, T Miki, M Mori, F Sakauchi, M Washio, T Kubo, K Wakai, A Tamakoshi, JOURNAL OF UROLOGY, 173, (5) 1502 - 1506,   2005年05月, 査読有り, Purpose: We assayed whether high serum carotenoids and antioxidative substances decrease the risk of urothelial cancer in. a case-control study nested in a community based cohort in Japan, that is the Japan Collaborative Cohort Study. Materials and Methods: Information on subject life-styles and serum were collected in 1988 to 1990 and subjects were followed as late as 1999. Individuals who had or died of urothelial cancer and controls were matched for study area, sex and age. Serum was stored at -80C and analyzed in 2003. Of 14,097 male and 25,662 female subjects 40 to 79 years old there were 42 cases, which were matched to 124 controls. Results: The OR for the highest to lowest tertile of serum concentration was 0.28 (95% CI 0.07 to 1.15, trend p = 0.08) for beta-carotene, 0.36 (95% CI 0.10 to 1.27, trend p = 0.10) for total carotenes and 0.31 (95% CI 0.09 to -1.09, trend p = 0.09) for total carotenoids after adjustment for smoking in addition to matching variables. High concentrations of tocopherols and xanthophylls slightly tended to decrease the risk of urothelial cancer. In contrast, serum retinol, oxidized low density lipoprotein and Cu/Zn-superoxide dismutase were not associated with urothelial cancer risk. Conclusions: Our results suggest that high serum carotenoids may decrease the risk of urothelial cancer with carotenes more effective than xanthophylls.
  • Cigarette smoking and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort study, Y Niwa, K Wakai, S Suzuki, K Tamakoshi, Y Lin, H Yatsuya, T Kondo, K Nishio, A Yamamoto, S Tokudome, N Hamajima, H Toyoshima, A Tamakoshi, JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 31, (2) 144 - 151,   2005年04月, 査読有り, Aim: The many studies into the relation between cigarette smoking and the risk of ovarian cancer have produced inconsistent results. Here we investigated this relation using data from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, initiated in 1988. Methods: A self-administered questionnaire on smoking habits and other risk factors for cancer was completed by 34 639 Japanese women. After 7.6 years of follow up, 39 cases of ovarian cancer were available for analyses. Cox proportional-hazards models were used to compute relative risks (RR) and to adjust for confounders. Results: Relative to those who had never smoked, the RR of ovarian cancer were 1.63 (95% confidence interval [CI] = 0.21-12.50) for former smokers and 2.27 (95% CI = 0.85-6.08) for current smokers. Among current smokers, the RR were 1.48 (95% CI = 0.20-10.92), 5.56 (95% CI = 1.68-19.06), and 1.86 (95% CI = 0.25-14.30) among women who smoked <10, 10-19, and at least 20 pack-years ([number of cigarettes smoked per day/20] x number of years subject has smoked), respectively, relative to those who had never smoked. A test for trend was statistically significant (P = 0.044). Conclusions: These data indicate that cigarette smoking increases the risk of developing ovarian cancer in the Japanese population.
  • Serum levels of polyunsaturated fatty acids and risk of colorectal cancer: A prospective study, M Kojima, K Wakai, S Tokudome, K Suzuki, K Tamakoshi, Y Watanabe, M Kawado, S Hashimoto, N Hayakawa, K Ozasa, H Toyoshima, S Suzuki, Y Ito, A Tamakoshi, AMERICAN JOURNAL OF EPIDEMIOLOGY, 161, (5) 462 - 471,   2005年03月, 査読有り, To examine the relation between serum fatty acids and risk of colorectal cancer, the authors conducted a nested case-control study of 169 colorectal cancer cases and 481 controls matched by age and enrollment area as part of the Japan Collaborative Cohort Study. Serum samples were donated by subjects at baseline (between 1988 and 1990) and were stored at -80degreesC until 2002. Serum fatty acid levels were measured by using gas chromatography and were expressed as the weight percentage of total lipids. Conditional logistic regression analyses adjusted for lifestyle factors revealed that total omega-3 polyunsaturated fatty acids (odds ratio = 0.24, 95% confidence interval: 0.08, 0.76), alpha-linolenic acid (odds ratio = 0.39, 95% confidence interval: 0.16, 0.91), docosapentaenoic acid (odds ratio = 0.30, 95% confidence interval: 0.11, 0.80), and docosahexaenoic acid (odds ratio = 0.23, 95% confidence interval: 0.07, 0.76) all showed a significantly decreased risk for the highest versus the lowest quartile levels for colorectal cancer in men. For women, a weak negative association was observed between docosapentaenoic acid and colorectal cancer risk, although it was not statistically significant. No adverse effects of high serum levels of omega-6 polyunsaturated fatty acids on colorectal cancer risk were detected.
  • Smoking and drinking habits five years after baseline in the JACC study., Kawado M, Suzuki S, Hashimoto S, Tokudome S, Yoshimura T, Tamakoshi A, JACC Study Group, Journal of epidemiology / Japan Epidemiological Association, 15 Suppl 1, S56 - 66,   2005年03月, 査読有り
  • Change in food intake frequency at five years after baseline in the JACC Study., Suzuki S, Kawado M, Hashimoto S, Tokudome S, Yoshimura T, Tamakoshi A, for the JACC, Study Group, J. Epidemiol., 15, (Sup 1) S48 - S55,   2005年03月
  • Updated information on risk factors for lung cancer: Findings from the JACC study, K. Wakai, M. Ando, K. Ozasa, Y. Ito, K. Suzuki, Y. Nishino, S.-I. Kuriyama, N. Seki, T. Kondo, Y. Watanabe, Y. Ohno, A. Tamakoshi, M. Mori, Y. Motohashi, I. Tsuji, Y. Nakamura, H. Iso, H. Mikami, Y. Inaba, Y. Hoshiyama, H. Suzuki, H. Shimizu, H. Toyoshima, S. Tokudome, S. Hashimoto, S. Kikuchi, A. Koizumi, T. Kawamura, T. Miki, C. Date, K. Sakata, T. Nose, N. Hayakawa, T. Yoshimura, A. Shibata, N. Okamoto, H. Shio, T. Kitagawa, T. Kuroki, K. Tajima, Journal of Epidemiology, 15, (SUPPL. 2) ,   2005年, 査読有り
  • Is the proportion of infection-related cancers much greater than generally appreciated?, S Tokudome, S Suzuki, M Kojima, A Hosono, INTERNATIONAL JOURNAL OF CANCER, 113, (3) 509 - 509,   2005年01月
  • Perceived psychologic stress and colorectal cancer mortality: Findings from the Japan collaborative cohort study, M Kojima, K Wakai, S Tokudome, K Tamakoshi, H Toyoshima, Y Watanabe, N Hayakawa, K Suzuki, S Hashimoto, M Kawado, S Suzuki, Y Ito, A Tamakoshi, PSYCHOSOMATIC MEDICINE, 67, (1) 72 - 77,   2005年01月, 査読有り, Objective: The purpose of this research was to examine the relationship between perceived psychologic stress and colorectal cancer mortality in a prospective large-scale study. Methods: Between the years 1988 and 1990, 32,153 men and 45,854 women aged 40 to 79 years were enrolled. Participants completed a self-administered questionnaire that addressed demographic, lifestyle, and psychosocial characteristics. Subjects were subsequently followed for mortality until the end of 1999. Perceived psychologic stress was assessed using the question "Do you feel stress during your daily life?" The 4 possible responses, ranging from "little or none" (1) to "extreme" (4), were dichotomized as low (I or 2) or high (3 or 4) stress. Relative risks (RRs) with 95% confidence intervals (CIs) for colon and rectal cancer according to the perceived level of stress were estimated using Cox's proportional hazard model. Results: During the follow-up period (average, 9.6 years), 193 colon cancer deaths (96 men and 97 women) and 127 rectal cancer deaths (88 men and 39 women) were confirmed within the study group. Women who reported high stress had a 1.64-fold higher risk of colon cancer mortality (multivariate-adjusted RR, 1.64; 95% CI, 1.01-2.66) compared with those reporting low stress. There was no significant association between perceived stress and female rectal cancer or male colon and rectal cancer mortality. Conclusions: Perceived psychologic stress was weakly associated with increased mortality from colon cancer in women. No positive or inverse association was found in men. Further studies are needed to confirm our results.
  • Serum carotenoids, retinol, and tocopherols, and colorectal cancer risk in a Japanese cohort: effect modification by sex for carotenoids., Wakai K, Suzuki K, Ito Y, Kojima M, Tamakoshi K, Watanabe Y, Toyoshima H, Hayakawa N, Hashimoto S, Tokudome S, Suzuki S, Kawado M, Ozasa K, Tamakoshi A, Japan Collaborative Cohort, Study Group, Nutrition and cancer, 51, (1) 13 - 24,   2005年, 査読有り
  • Methylenetetrahydrofolate reductase gene (MTHFR) polymorphisms and reduced risk of malignant lymphoma, K Matsuo, N Hamajima, R Suzuki, M Ogura, Y Kagami, H Taji, T Yasue, NE Mueller, S Nakamura, M Seto, T Morishima, K Tajima, AMERICAN JOURNAL OF HEMATOLOGY, 77, (4) 351 - 357,   2004年12月, 査読有り, Folate and methionine are important nutrients in the "one-carbon" metabolism that is closely associated with DNA synthesis and DNA methylation. Genetic variation in these pathways may change susceptibility to cancer development. We have previously reported associations between lymphoma risk and germline polymorphisms in genes of methylenetetrahydrofolate reductase (MTHFR C677T and A1298C) and methionine synthase (MTR A2756G), finding the genotype other than the MTHFR 677CC/1298AA to confer a half-risk compared, to the MTHFR 677CC/1298AA and a 3-fold higher risk with the MTR GG genotype than the AA/AG genotypes. To confirm the association and explore the histological difference, we extended the previous case series. A case-control study was conducted in Japan with a total of 372 lymphoma cases and 500 noncancer controls examined for genotypes. The relative risks were estimated by unconditional logistic regression analysis. In overall analyses, the age-sex adjusted odds ratio (OR) for the subjects harboring MTHFR 677T or 1298C alleles relative to 677CC/1298AA genotype was 0.58 (95% confidence interval: 0.41-0.83, P = 0.002). The MTR GG genotype showed an OR of 1.75 (0.87-3.52, P = 0.114). These findings were validated in separate analyses of the 273 new incident cases. Subgroup analyses according to histological subtype [diffuse large B-cell lymphoma (DLB), follicular lymphoma (FL), low-grade lymphoma of mucosa associated lymphoid tissue (MALT), and others] illustrated similar associations with certain exceptions for FL and MALT. Our data showed an association between the MTHFR polymorphisms and malignant lymphoma risk for all histological subtypes, although the extent of contribution of these polymorphisms may differ somewhat with histological subtype. Lack of association with MTR polymorphism was also confirmed. (C) 2004 Wiley-Liss, Inc.
  • Serum oxidized low-density lipoprotein levels and risk of colorectal cancer: a case-control study nested in the Japan Collaborative Cohort Study., Suzuki K, Ito Y, Wakai K, Kawado M, Hashimoto S, Toyoshima H, Kojima M, Tokudome S, Hayakawa N, Watanabe Y, Tamakoshi K, Suzuki S, Ozasa K, Tamakoshi A, Japan Collaborative Cohort, Study Group, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 13, (11 Pt 1) 1781 - 1787,   2004年11月, 査読有り
  • A prospective study of reproductive and menstrual factors and colon cancer risk in Japanese women: Findings from the JACC study, K Tamakoshi, K Wakai, M Kojima, Y Watanabe, N Hayakawa, H Toyoshima, H Yatsuya, T Kondo, S Tokudome, S Hashimoto, K Suzuki, S Suzuki, M Kawado, K Ozasa, Y Ito, A Tamakoshi, CANCER SCIENCE, 95, (7) 602 - 607,   2004年07月, 査読有り, The effects of reproductive factors on the etiology of colon cancer in Asian populations remain unexplored. So we examined 38,420 Japanese women aged 40-79 years who responded to a questionnaire on reproductive and other lifestyle factors from 1988 to 1990 in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. During an average 7.6 years of follow-up, we documented 207 incident colon cancers. Multivariate analysis indicated that colon cancer risk was likely to be lower among parous women than among nulliparous. Women who had two abortions or more had a 72% higher risk of developing colon cancer [relative risk (RR) 1.72; 95% confidence interval (CI) 1.16-2.55; trend P<0.01] compared with women who never had an abortion. The RR of colon cancer among postmenopausal women significantly decreased with increasing age at menarche (trend P=0.01). No apparent association between colon cancer and gravida, age at first birth, age at menopause, or duration of menstruation was seen. These prospective data support the hypothesis that female reproductive events modify colon cancer risk, and suggest that reproductive factors, particularly age at menarche and having an abortion, may be of importance in the etiology of colon cancer among Japanese women.
  • The conditional relative odds ratio provided less biased results for comparing diagnostic test accuracy in meta-analyses, S Suzuki, T Moro-oka, NK Choudhry, JOURNAL OF CLINICAL EPIDEMIOLOGY, 57, (5) 461 - 469,   2004年05月, Objective: Meta-analytic techniques are used to combine the results of different studies that have evaluated the accuracy of a given diagnostic test. The techniques commonly generate values that either describe the performance of a particular test or compare the discriminative ability of two tests. The later has received very little attention in the literature, and is the focus of this article. Study Design and Setting: We summarize existing methods based on an odds ratio (OR) and propose a novel technique for conducting such analysis, the conditional relative odds ratio (CROR). We demonstrate how to extract the required data and calculate several different comparative indexes using a hypothetic example. Results: A paired analysis is preferred to decrease selection bias and increase statistical power. There is no standard method of obtaining the standard error (SE) of each relative OR; thus, the SE of the summary index might be underestimated under the assumption of no within-study variability. Conclusion: The CROR method estimates less biased indexes with SEs, and conditioned on discordant results, it is much less problematic ethically and economically. However, small cell counts may lead to larger SEs, and it might be impossible to construct McNemar's 2 x 2 tables for some studies. (C) 2004 Elsevier Inc. All rights reserved.
  • A prospective study of body size and colon cancer mortality in Japan: The JACC Study, K Tamakoshi, K Wakai, M Kojima, Y Watanabe, N Hayakawa, H Toyoshima, H Yatsuya, T Kondo, S Tokudome, S Hashimoto, K Suzuki, Y Ito, A Tamakoshi, INTERNATIONAL JOURNAL OF OBESITY, 28, (4) 551 - 558,   2004年04月, 査読有り, OBJECTIVE: To determine whether body size measurements are risk factors for colon cancer death among the Japanese. DESIGN AND SUBJECTS: A nationwide prospective study, the Japan Collaborative Cohort (JACC) Study from 1988 to 1999. The present analysis included 43 171 men and 58 775 women aged 40 - 79 y who respond to a questionnaire on current weight and height, weight around 20 y of age, and other lifestyle factors. Body mass index (BMI) at baseline and 20 y of age (B-BMI and 20-BMI, respectively) were calculated. RESULTS: We identified 127 deaths from colon cancer during the follow-up of 424 698 person-years among men and 122 deaths during the follow-up of 591 787 person-years among women. After adjustments for the lifestyle factors known to modify the risk of colon cancer, weight at baseline showed a significant positive association in women, while no such association was seen in men. There was also a significant trend of increasing risk with the increase in B-BMI among women. Women with B-BMI greater than or equal to28 kg/m(2) had a relative risk (RR) of 3.41 (95% confidence interval (CI): 1.44 - 8.06) compared with those with BMI of 20- <22 kg/m(2). 20-BMI also presented the same trend of increasing risk as B- BMI. Women with 20-BMI of <22 and B-BMI of >26 kg/m(2), that is, excessive BMI gain, had a high RR of 3.41 (95% CI 1.29 - 9.02) compared with those with 20- BMI of <22 and B-BMI of <22 kg/m(2). There were no corresponding trends of colon cancer risk for B- BMI, 20- BMI, or BMI change among men. CONCLUSIONS: These study data suggest that obesity and excessive weight gain are associated with the risk of colon cancer death in Japanese women but no such relationship was found in Japanese men.
  • No associations of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms with the risk of digestive tract cancers in Japanese, N Hamajima, K Matsuo, T Suzuki, T Nakamura, A Matsuura, S Hatooka, M Shinoda, Y Kodera, Y Yamamura, T Hirai, T Kato, K Tajima, CANCER LETTERS, 181, (1) 81 - 85,   2002年07月, 査読有り, A case-control study was conducted to examine the possible association between digestive tract cancers and p73 G4C14-to-A4TI4 at exon 2 and p53 Arg72Pro polymorphisms in Japanese. Cases were 102 esophageal cancer patients, 144 stomach cancer patients, and 147 colorectal cancer patients, and controls were 241 non-cancer outpatients. The genotype frequencies among controls were 55.3% for p73 GG at position 4, 40.4% for GA, and 4.3% for AA, and 37.7% for p53 ArgArg, 44.4% for ArgPro, and 18.0% for ProPro. No significant differences in the genotype frequencies were observed between the controls and each case group or case, as a whole. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
  • Helicobacter pylori IgG antibody test established in the United States showed a substantially lower sensitivity for Japanese population, K Matsuo, N Hamajima, S Tominaga, T Suzuki, T Nakamura, A Matsuura, K Kitayama, AMERICAN JOURNAL OF GASTROENTEROLOGY, 95, (6) 1597 - 1598,   2000年06月, 査読有り
  • 某地域住民の高血糖者における血清カロテノイド値の検討, 鈴木康司, 伊藤宜則, 大谷元彦, 鈴木貞夫, 青木國雄, 日本衛生学雑誌, 55, (2) 481 - 488,   2000年02月, 査読有り
  • Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils, K Suzuki, T Kawamura, F Sakakibara, H Sasaki, T Sano, N Sakamoto, N Hotta, DIABETIC MEDICINE, 16, (1) 67 - 73,   1999年01月, 査読有り, Aim. To investigate the influence of glucose and the efficacy of two different aldose reductase (AR) inhibitors, epalrestat and SNK-860, on the polyol pathway and myo-inositol metabolism in human neutrophils. Methods. We incubated neutrophils with various concentrations of glucose and AR inhibitors. The neutrophils from healthy volunteers were incubated in the media containing 5-40 mmol/l glucose with or without an AR inhibitor. The sorbitol and myo-inositol contents, and myo-inositol uptake were measured by high performance liquid chromatography and radio isotope technique with 2-[H-3]-myo-inositol. Results. After 2 h incubation, the sorbitol content increased with rising extracellular glucose concentrations, while the Inyo-inositol content decreased. Both AR inhibitors reduced the sorbitol content in neutrophils exposed to 40 mmol/l glucose medium. A 70% fall in the myo-inositol content in neutrophils exposed to 40 mmol/l glucose medium was attenuated approximate to 40% by the addition of AR inhibitors. myo-Inositol uptake into neutrophils was inhibited by high glucose. AR inhibitors significantly ameliorated the decrease in myo-inositol uptake, but did not completely normalize it. Conclusions. Our present in vitro studies showed that the glucose-induced metabolic alterations in human neutrophils were similar to those in tissues prone to diabetic complications, and that AR inhibitors effectively corrected glucose-induced imbalances of the polyol pathway and myo-inositol uptake in neutrophils. In addition, our study suggests that glucose-induced metabolic alterations may result in the neutrophil dysfunction and that an AR inhibitor may be capable ameliorating it.
  • Epidemiology of breast cancer in Japan, Wakai K, Suzuki S, Ohno Y, Kawamura T, Tamakoshi A, Aoki R, Int J Epidemiol, 24, (2) ,   1995年04月, 査読有り
  • A nationwide survey of congenital hydrocephalus in Japan - Estimated prevalence and incidence, Tamakoshi A, Sasaki R, Hamajima N, Aoki K, Suzuki S, Yanagawa H, Kikuchi H, Watanabe K, Eur J Publ Health, 1,   1991年, 査読有り

MISC

  • 一般住民における職種と主観的ストレスとの関連:J‐MICC Study 岡崎, 依馬加苗, 中川弘子, 渡邉美貴, 細野晃弘, 細野晃弘, 柴田清, 近藤文, 若林諒三, 市川麻理, 野口泰司, 野口泰司, 上島寛之, 上島寛之, 尚爾華, 尚爾華, 永谷憲司, 鈴木貞夫, 日本公衆衛生学会総会抄録集, 78th,   2019年10月10日
  • 一般住人におけるコーヒー摂取とメタボリックシンドロームとの関連 J‐MICC Study岡崎, 依馬加苗, 中川弘子, 西山毅, 渡邉美貴, 細野晃弘, 柴田清, 柴田清, 近藤文, 若林諒三, 市川麻理, 野口泰司, 野口泰司, 上島寛之, 上島寛之, 永谷憲司, 山田珠樹, 鈴木貞夫, 東海公衆衛生雑誌, 7, (1) 53 - 53,   2019年07月06日
  • 職場と家庭でのストレスと健診成績との関連 J‐MICC岡崎研究, 渡邉美貴, 中川弘子, 西山毅, 細野晃弘, 細野晃弘, 柴田清, 柴田清, 近藤文, 若林諒三, 市川麻理, 野口泰司, 永谷憲司, 依馬加苗, 山田珠樹, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 29th,   2019年01月30日
  • 一般住民におけるコーヒー摂取量と血清中性脂肪の関連:J‐MICC Study岡崎, 依馬加苗, 中川弘子, 西山毅, 渡邉美貴, 細野晃弘, 柴田清, 近藤文, 若林諒三, 市川麻理, 野口泰司, 永谷憲司, 山田珠樹, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 29th,   2019年01月30日
  • 一般住民における受動喫煙の暴露と抑うつ状態の関連:J‐MICC Study岡崎, 野口泰司, 細野晃弘, 細野晃弘, 中川弘子, 西山毅, 渡邉美貴, 玉井裕也, 玉井裕也, 柴田清, 柴田清, 近藤文, 市川麻理, 若林諒三, 永谷憲司, 依馬加苗, 山田珠樹, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 29th,   2019年01月30日
  • 介護負担と幸福感の関連および社会参加との交互作用の検討:J‐MICC岡崎研究, 野口泰司, 細野晃弘, 細野晃弘, 玉井裕也, 玉井裕也, 中川弘子, 渡邉美貴, 岡京子, 近藤文, 市川麻里, 若林諒三, 永谷憲司, 依馬加苗, 鈴木貞夫, 日本公衆衛生学会総会抄録集, 77th,   2018年10月09日
  • 介護負担と幸福感の関連および社会参加との交互作用の検討 J-MICC岡崎研究, 野口 泰司, 細野 晃弘, 玉井 裕也, 中川 弘子, 渡邉 美貴, 岡 京子, 近藤 文, 市川 麻里, 若林 諒三, 永谷 憲司, 依馬 加苗, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 77回,   2018年10月
  • 平成28年度国民生活基礎調査に基づくわが国の関節リウマチ患者の疫学像, 小嶋 雅代, 中山 健夫, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 77回,   2018年10月
  • GWASとSNP-set Kernel Association Tests(SKAT)により見出されたPSCA遺伝子とピロリ菌関連胃粘膜萎縮の関連(The association of PSCA gene and H. pylori-related gastric atrophy risk detected by GWAS and SKAT), 菱田 朝陽, 藤井 亮輔, 中杤 昌弘, 川合 紗世, 伊藤 秀美, 松尾 恵太郎, 渡邉 美貴, 鈴木 貞夫, 栗山 長門, 内藤 真理子, 若井 建志, 日本癌学会総会記事, 77回,   2018年09月
  • 前立腺癌発症とインスリン抵抗性に関する前向きコホート研究, 安藤 亮介, 鈴木 貞夫, 細野 晃弘, 山田 珠樹, 田中 勇太朗, 飯田 啓太郎, 惠谷 俊紀, 内木 拓, 河合 憲康, 戸澤 啓一, 安井 孝周, 日本泌尿器科学会総会, 106回,   2018年04月
  • 尿路結石発症とインスリン抵抗性に関する前向きコホート研究, 安藤 亮介, 鈴木 貞夫, 細野 晃弘, 山田 珠樹, 海野 怜, 濱本 周造, 広瀬 真仁, 岡田 淳志, 戸澤 啓一, 郡 健二郎, 安井 孝周, 日本泌尿器科学会総会, 106回,   2018年04月
  • 尿路結石発症とインスリン抵抗性に関する前向きコホート研究, 安藤 亮介, 鈴木 貞夫, 細野 晃弘, 山田 珠樹, 海野 怜, 田口 和己, 浜本 周造, 岡田 淳志, 安井 孝周, 日本腎臓学会誌, 60, (3) 383 - 383,   2018年04月
  • 地域住民における出生体重の糖尿病関連因子への影響, 神谷真有美, 細野晃弘, 柴田清, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 近藤文, 若林諒三, 山田珠樹, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 28th,   2018年02月01日
  • ピロリ菌感染者における除菌治療の体重変化に与える影響, 玉井裕也, 細野晃弘, 渡邉美貴, 辻村尚子, 藤田ひとみ, 岡本尚子, 荒井健介, 市川麻理, 岡京子, 神谷真有美, 近藤文, 若林諒三, 野口泰司, 上島寛之, 鈴木貞夫, 日本公衆衛生学会総会抄録集, 76th,   2017年10月15日
  • 主観的な食意識が身体に及ぼす影響について―食塩に着目した検討―, 上島寛之, 上島寛之, 細野晃弘, 玉井裕也, 渡邉美貴, 柴田清, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 市川麻理, 若林諒三, 野口泰司, 鈴木貞夫, 日本公衆衛生学会総会抄録集, 76th,   2017年10月15日
  • 腹囲はBMIと比べてHbA1cの上昇を予見するか, 細野晃弘, 細野晃弘, 柴田清, 柴田清, 辻村尚子, 市川麻理, 玉井裕也, 渡邉美貴, 藤田ひとみ, 岡本尚子, 岡京子, 神谷真有美, 近藤文, 若林諒三, 野口泰司, 上島寛之, 鈴木貞夫, 日本公衆衛生学会総会抄録集, 76th,   2017年10月15日
  • ピロリ菌感染,慢性胃炎とBMI,腹囲との関連について, 鈴木貞夫, 細野晃弘, 玉井裕也, 渡邉美貴, 柴田清, 辻村尚子, 藤田ひとみ, 岡本尚子, 岡京子, 神谷真有美, 近藤文, 市川麻理, 若林諒三, 野口泰司, 上島寛之, 日本公衆衛生学会総会抄録集, 76th,   2017年10月15日
  • 壮年期における地域組織への社会参加と高血圧の関連について J‐MICC岡崎研究, 野口泰司, 細野晃弘, 玉井裕也, 柴田清, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 市川麻理, 若林諒三, 上島寛之, 渡邉美貴, 鈴木貞夫, 日本公衆衛生学会総会抄録集, 76th,   2017年10月15日
  • 出生年別Helicobacter pylori(ピロリ菌)感染率の特徴 J-MICC岡崎Study, 渡邉 美貴, 細野 晃弘, 玉井 裕也, 柴田 清, 辻村 尚子, 藤田 ひとみ, 岡本 尚子, 市川 麻理, 岡 京子, 神谷 真有美, 近藤 文, 若林 諒三, 野口 泰司, 上島 寛之, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 76回,   2017年10月
  • Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women, Takagi S, Naito M, Kawai S, Okada R, Nagata C, Hosono S, Nishida Y, Takashima N, Suzuki S, Shimoshikiryo I, Mikami H, Uemura H, Kuriyama N, Ohnaka K, Kubo M, Hamajima N, Tanaka H, Wakai K, Br J Nutr, 118,   2017年09月, 査読有り
  • SNP-set Kernel Association Tests(SKAT)により見出されたTLR2遺伝子とピロリ菌関連胃粘膜萎縮の関連, 菱田 朝陽, 藤井 亮輔, 中杤 昌弘, 川合 紗世, 尾瀬 功, 松尾 恵太郎, 玉井 裕也, 鈴木 貞夫, 栗山 長門, 渡邊 能行, 内藤 真理子, 若井 建志, 日本癌学会総会記事, 76回,   2017年09月
  • 腎結石と5つの生活習慣病が慢性腎臓病の診断におよぼす影響, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 海野 怜, 濱本 周造, 岡田 淳志, 戸澤 啓一, 安井 孝周, 日本腎泌尿器疾患予防医学研究会誌, 25, (1) 56 - 57,   2017年03月
  • 若年期の運動習慣が壮年期以降のインスリン抵抗性へ及ぼす影響, 藤田ひとみ, 柴田清, 辻村尚子, 岡京子, 岡本尚子, 神谷真有美, 近藤文, 若林諒三, 市川麻理, 上島寛之, 望月美咲, 玉井裕也, 細野晃弘, 山田珠樹, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 27th,   2017年01月25日
  • メタボリックシンドロームにおける腹囲の情報の意義, 辻村尚子, 辻村尚子, 細野晃弘, 玉井裕也, 柴田清, 荒井健介, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 若林諒三, 市川麻理, 上島寛之, 望月美咲, 山田珠樹, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 27th,   2017年01月25日
  • 健康アウトカムの違いによる自覚的ストレス及び睡眠の質・睡眠時間の関連の傾向, 若林諒三, 細野晃弘, 玉井裕也, 柴田清, 辻村尚子, 岡京子, 岡本尚子, 藤田ひとみ, 神谷真有美, 近藤文, 市川麻理, 望月美咲, 上島寛之, 荒井健介, 山田珠樹, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 27th,   2017年01月25日
  • 出生体重と糖尿病,インスリン抵抗性との関連, 神谷真有美, 細野晃弘, 玉井裕也, 柴田清, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 近藤文, 市川麻理, 若林諒三, 望月美咲, 上島寛之, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 27th,   2017年01月25日
  • スポット尿による食塩摂取量推定式の精度向上を目的としたNa/Cr比と尿回数を用いた補正の検討, 上島寛之, 細野晃弘, 玉井裕也, 柴田清, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 若林諒三, 市川麻理, 望月美咲, 山田珠樹, 鈴木貞夫, 日本疫学会学術総会講演集(Web), 27th,   2017年01月25日
  • 出生体重と糖尿病既往との関連, 神谷 真有美, 細野 晃弘, 柴田 清, 玉井 裕也, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 近藤 文, 市川 麻理, 若林 諒三, 望月 美咲, 上島 寛之, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 75回,   2016年10月
  • 閉経原因による骨密度と生活習慣との関連, 辻村 尚子, 細野 晃弘, 柴田 清, 玉井 裕也, 岡 京子, 岡本 尚子, 藤田 ひとみ, 神谷 真有美, 近藤 文, 市川 麻理, 若林 諒三, 片桐 辰徳, 上島 寛之, 望月 美咲, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 75回,   2016年10月
  • カテゴリー分類における地域住民のBMIと腹囲の自己申告値の正確性, 岡本 尚子, 細野 晃弘, 柴田 清, 玉井 裕也, 辻村 尚子, 岡 京子, 藤田 ひとみ, 神谷 真有美, 近藤 文, 若林 諒三, 市川 麻理, 片桐 辰徳, 上島 寛之, 望月 美咲, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 75回,   2016年10月
  • 中壮年期から高齢期における複数回の転倒経験と社会との関わり, 片桐 辰徳, 細野 晃弘, 柴田 清, 玉井 裕也, 辻村 尚子, 岡 京子, 岡本 尚子, 藤田 ひとみ, 神谷 真由美, 近藤 文, 市川 麻理, 若林 諒三, 上島 寛之, 望月 美咲, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 75回,   2016年10月
  • 主観的幸福感低下度の介護負担度との関連における男女差についての考察, 細野 晃弘, 柴田 清, 玉井 裕也, 辻村 尚子, 岡 京子, 岡本 尚子, 藤田 ひとみ, 神谷 真有美, 近藤 文, 片桐 辰徳, 市川 麻理, 若林 諒三, 上島 寛之, 望月 美咲, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 75回,   2016年10月
  • 食事摂取頻度調査における欠測データ補完に関する検討, 市川 麻理, 細野 晃弘, 玉井 裕也, 荒井 健介, 辻村 尚子, 岡 京子, 岡本 尚子, 藤田 ひとみ, 神谷 真有美, 近藤 文, 若林 諒三, 上島 寛之, 望月 美咲, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 75回,   2016年10月
  • 食塩摂取量推定精度の向上を目的とした尿中クレアチニン排泄量と食事時間の関連の検討, 上島 寛之, 細野 晃弘, 柴田 清, 玉井 裕也, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 片桐 辰徳, 若林 諒三, 市川 麻理, 望月 美咲, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 75回,   2016年10月
  • 健診受診者の随時尿と起床後第2尿から推定した食塩摂取量と血圧との関連, 望月 美咲, 細野 晃弘, 柴田 清, 玉井 裕也, 辻村 尚子, 岡 京子, 岡本 尚子, 藤田 ひとみ, 神谷 真有美, 近藤 文, 片桐 辰徳, 市川 麻理, 若林 諒三, 上島 寛之, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 75回,   2016年10月
  • 腎結石が慢性腎臓病の診断基準におよぼす影響, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 海野 怜, 浜本 周造, 岡田 淳志, 戸澤 啓一, 郡 健二郎, 安井 孝周, 日本泌尿器科学会総会, 104回,   2016年04月
  • 水溶性食物繊維であるイヌリンの整腸効果に関するシステマティックレビュー, 原健二郎, 和田正, 辻修一, 磯村達也, 近藤文, 鈴木貞夫, 若林敬二, 日本農芸化学会大会講演要旨集(Web), 2016,   2016年03月05日
  • 閉経前女性の骨密度の変化とその関連因子, 辻村尚子, 細野晃弘, 荒井健介, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 片桐辰徳, 若林諒三, 尚爾華, 上島寛之, 望月美咲, 鈴木貞夫, Journal of Epidemiology (Web), 26,   2016年01月21日
  • 地域住民における食塩摂取量と生活習慣に関する研究―食塩摂取量とアルコール摂取との関連―, 上島寛之, 細野晃弘, 荒井健介, 岡京子, 辻村尚子, 岡本尚子, 藤田ひとみ, 神谷真有美, 近藤文, 片桐辰徳, 若林諒三, 望月美咲, 鈴木貞夫, Journal of Epidemiology (Web), 26,   2016年01月21日
  • イヌリンによる腸内ビフィズス菌数増加に関するメタアナリシス, 近藤文, 近藤文, 鈴木貞夫, 磯村達也, 磯村達也, 細野晃弘, 辻修一, 原健二郎, 若林敬二, Journal of Epidemiology (Web), 26,   2016年01月21日
  • メタボリックシンドロームと尿路結石, 安藤亮介, 鈴木貞夫, 細野晃弘, 山田珠樹, 田口和己, 藤井泰普, 岡田淳志, 戸澤啓一, 郡健二郎, 安井孝周, 日本泌尿器科学会総会(Web), 104th,   2016年
  • 腎結石と5つの生活習慣病との交互作用からみた慢性腎臓病の発症メカニズムの解明, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 海野 怜, 濱本 周造, 岡田 淳志, 戸澤 啓一, 安井 孝周, 郡 健二郎, 日本尿路結石症学会誌, 14, (2) 136 - 139,   2015年11月
  • 未閉経者の骨密度追跡調査, 辻村 尚子, 小嶋 雅代, 細野 晃弘, 荒井 健介, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 片桐 辰則, 若林 諒三, 尚 爾華, 上島 寛之, 望月 美咲, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 74回,   2015年10月
  • 地域住民における食塩摂取量評価法の比較と活用法の検討, 上島 寛之, 小嶋 雅代, 細野 晃弘, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 片桐 辰徳, 若林 諒三, 望月 美咲, 尚 爾華, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 74回,   2015年10月
  • 起床後第2尿を用いた地域住民の食塩摂取状況の把握, 望月 美咲, 小嶋 雅代, 細野 晃弘, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 片桐 辰徳, 若林 諒三, 上島 寛之, 尚 爾華, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 74回,   2015年10月
  • イヌリンの腸内環境改善についてのシステマティックレビュー, 近藤 文, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 74回,   2015年10月
  • 地域住民における睡眠障害と関連する仕事のストレス要因の検討, 若林 諒三, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 片桐 辰徳, 細野 晃弘, 小嶋 雅代, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 74回,   2015年10月
  • 腎結石と5つの生活習慣病との交互作用からみた慢性腎臓病の発症メカニズムの解明, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 海野 怜, 濱本 周造, 岡田 淳志, 戸澤 啓一, 安井 孝周, 郡 健二郎, 日本尿路結石症学会誌, 14, (1) 80 - 80,   2015年07月
  • 腎結石による慢性腎臓病の発症リスクと交互作用の検討, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 岡田 淳志, 安井 孝周, 戸澤 啓一, 郡 健二郎, 日本腎臓学会誌, 57, (3) 575 - 575,   2015年04月
  • 慢性腎臓病の発症予防をめざした腎結石と生活習慣病との交互作用の検討, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 海野 怜, 田口 和己, 高橋 英勝, 河合 信, 岡田 淳志, 安井 孝周, 伊藤 恭典, 戸澤 啓一, 郡 健二郎, 日本泌尿器科学会総会, 103回,   2015年04月
  • 地域住民における血清DHEA-S濃度に関連する因子, 荒井 健介, 鈴木 貞夫, 小嶋 雅代, 細野 晃弘, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 片桐 辰徳, 若林 諒三, 日本公衆衛生学会総会抄録集, 73回,   2014年10月
  • 高齢者の転倒経験と生活習慣に関する横断研究, 辻村 尚子, 柴田 清, 荒井 健介, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 片桐 辰徳, 若林 諒三, 細野 晃弘, 小嶋 雅代, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 73回,   2014年10月
  • 地域住民における栄養バランスと主観的健康感との関連, 近藤 文, 柴田 清, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 片桐 辰徳, 若林 諒三, 細野 晃弘, 小嶋 雅代, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 73回,   2014年10月
  • 縦断研究からみた腎結石による慢性腎臓病の発症リスク, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 田口 和己, 廣瀬 泰彦, 岡田 淳志, 安井 孝周, 戸澤 啓一, 郡 健二郎, 日本泌尿器科学会総会, 102回,   2014年04月
  • 肥満指標に関する考察―心血管疾患危険因子との関連について, 神谷真有美, 小嶋雅代, 柴田清, 細野晃弘, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 近藤文, 鈴木美奈, 鈴木貞夫, Journal of Epidemiology, 24,   2014年01月23日
  • 地域住民における主観的な健康感とBMIの関連について, 近藤文, 鈴木貞夫, 小嶋雅代, 柴田清, 細野晃弘, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 鈴木美奈, Journal of Epidemiology, 24,   2014年01月23日
  • 慢性萎縮性胃炎の疫学―肥満との関連を中心に, 鈴木貞夫, 小嶋雅代, 細野晃弘, 柴田清, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 岡本尚子, 神谷真有美, 近藤文, 鈴木美奈, Journal of Epidemiology, 24,   2014年01月23日
  • 主観的幸福感の決定要因に関する疫学的検討, 小嶋 雅代, 細野 晃弘, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 鈴木 美奈, 柴田 清, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 72回,   2013年10月
  • 骨密度と現在の生活状況及び健康状態の自己評価に関する記述疫学, 荒井 健介, 細野 晃弘, 柴田 清, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 鈴木 美奈, 小嶋 雅代, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 72回,   2013年10月
  • 肥満指標に関する考察 心血管疾患危険因子との関連について, 神谷 真有美, 細野 晃弘, 柴田 清, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 近藤 文, 鈴木 美奈, 小嶋 雅代, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 72回,   2013年10月
  • 地域住民のペプシノーゲン検査による萎縮性胃炎の評価と関連因子について, 鈴木 貞夫, 小嶋 雅代, 細野 晃弘, 柴田 清, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 鈴木 美奈, 日本公衆衛生学会総会抄録集, 72回,   2013年10月
  • 地域住民における食習慣とHbA1cとの関連について, 近藤 文, 細野 晃弘, 柴田 清, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真由美, 鈴木 美奈, 小嶋 雅代, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 72回,   2013年10月
  • 医学生の喫煙に関する意識と行動に関する状況調査, 鈴木 美奈, 小嶋 雅代, 細野 晃弘, 荒井 健介, 辻村 尚子, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 72回,   2013年10月
  • 地域住民の転倒経験と睡眠に関する横断研究, 辻村 尚子, 細野 晃弘, 荒井 健介, 柴田 清, 岡 京子, 藤田 ひとみ, 岡本 尚子, 神谷 真有美, 近藤 文, 鈴木 美奈, 小嶋 雅代, 鈴木 貞夫, 日本公衆衛生学会総会抄録集, 72回,   2013年10月
  • 糖尿病既往は結腸がん罹患リスクを上昇させる JACC study報告, 細野 晃弘, 鈴木 貞夫, 小嶋 雅代, 鈴木 康司, 橋本 修二, 若井 建志, 玉腰 暁子, 渡邊 能行, 日本公衆衛生学会総会抄録集, 72回,   2013年10月
  • 縦断研究からみた腎結石による慢性腎臓病の発症リスク, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 田口 和己, 廣瀬 泰彦, 岡田 淳志, 安井 孝周, 戸澤 啓一, 郡 健二郎, 日本尿路結石症学会誌, 12, (1) 20 - 20,   2013年08月
  • 腎結石と慢性腎臓病・心血管疾患リスクに関する臨床疫学研究, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 岡田 淳志, 安井 孝周, 戸澤 啓一, 郡 健二郎, 日本尿路結石症学会誌, 11, (2) 81 - 84,   2013年07月
  • Obesity/weight gain and breast cancer risk: Findings from the Japan Collaborative Cohort Study for the Evaluation of Cancer Risk, Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Wakai K, Fujino Y, Lin Y, Kikuchi S, Tamakoshi K, Tamakoshi A, for the Japan Collaborative Cohort, Study Group, J Epidemiol, 23,   2013年03月05日, 査読有り
  • 腎結石と慢性腎臓病・心血管疾患リスクに関する臨床疫学研究, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 岡田 淳志, 安井 孝周, 戸澤 啓一, 郡 健二郎, 日本泌尿器科学会雑誌, 104, (2) 230 - 230,   2013年03月
  • 健診受診者における腎結石患者と慢性腎臓病・心血管疾患のリスク要因との関連, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 岡田 淳志, 安井 孝周, 戸澤 啓一, 郡 健二郎, 日本腎泌尿器疾患予防医学研究会誌, 21, (1) 96 - 97,   2013年03月
  • 人間ドックにおける細胞接着分子の分布と関連因子, 細野晃弘, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 神谷真有美, 近藤文, 鈴木美奈, 今枝奈保美, 石川奈美, 柴田清, 後藤千穂, 安藤亮介, 深津満, 山田珠樹, 徳留信寛, 鈴木貞夫, Journal of Epidemiology, 23,   2013年01月24日
  • 骨密度と食生活の関係について, 鈴木美奈, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 神谷真有美, 近藤文, 今枝奈保美, 石川奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, Journal of Epidemiology, 23,   2013年01月24日
  • 呼吸機能と骨密度および運動量の相関についての記述疫学, 荒井健介, 鈴木貞夫, 小嶋雅代, 西山毅, 辻村尚子, 岡京子, 藤田ひとみ, 神谷真有美, 近藤文, 鈴木美奈, 今枝奈保美, 石川奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, Journal of Epidemiology, 23,   2013年01月24日
  • 飲酒習慣及び喫煙習慣と骨密度の関連について, 近藤文, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 神谷真有美, 鈴木美奈, 今枝奈保美, 石川奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, Journal of Epidemiology, 23,   2013年01月24日
  • 人間ドックにおける萎縮性胃炎の分布と関連因子, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 岡京子, 藤田ひとみ, 神谷真有美, 近藤文, 鈴木美奈, 今枝奈保美, 石川奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, Journal of Epidemiology, 23,   2013年01月24日
  • 骨密度と女性症状, 岡京子, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 藤田ひとみ, 神谷真有美, 近藤文, 鈴木美奈, 今枝奈保美, 石川奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, Journal of Epidemiology, 23,   2013年01月24日
  • 人間ドック受診データによる気流閉塞と喫煙歴についての検討, 辻村尚子, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 岡京子, 藤田ひとみ, 神谷真有美, 近藤文, 鈴木美奈, 今枝奈保美, 石川奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, Journal of Epidemiology, 23,   2013年01月24日
  • 骨密度と関連する因子の記述疫学—岡崎研究ベースラインデータに基づく—, 荒井健介, 鈴木貞夫, 小嶋雅代, 辻村尚子, 藤田ひとみ, 今枝奈保美, 後藤千穂, 柴田清, 安藤亮介, 石川奈美, 細野晃弘, 徳留信寛, 日本公衆衛生学会総会抄録集, 71st,   2012年10月15日
  • 横断研究による転倒経験とQOLとの関係, 辻村尚子, 鈴木貞夫, 小嶋雅代, 荒井健介, 藤田ひとみ, 後藤千穂, 今枝奈保美, 柴田清, 安藤亮介, 石川奈美, 細野晃弘, 徳留信寛, 日本公衆衛生学会総会抄録集, 71st,   2012年10月15日
  • 強度別にみた身体活動量の記述疫学, 藤田ひとみ, 鈴木貞夫, 小嶋雅代, 荒井健介, 辻村尚子, 後藤千穂, 今枝奈保美, 柴田清, 安藤亮介, 石川奈美, 細野晃弘, 徳留信寛, 日本公衆衛生学会総会抄録集, 71st,   2012年10月15日
  • 名古屋市立大学大学院医学研究科・医学部禁煙推進委員会の活動報告, 鈴木 貞夫, 小嶋 雅代, 藤田 ひとみ, 岡 京子, 神谷 真有美, 近藤 文, 酒井 奈美, 日本公衆衛生学会総会抄録集, 71回,   2012年10月
  • 医学生の喫煙に関する調査より 浪人、留年と喫煙率について, 岡 京子, 鈴木 貞夫, 小嶋 雅代, 藤田 ひとみ, 神谷 真有美, 近藤 文, 酒井 奈美, 日本公衆衛生学会総会抄録集, 71回,   2012年10月
  • 医学生の喫煙に関する調査より 喫煙経験と年齢について, 酒井 美奈, 鈴木 貞夫, 小嶋 雅代, 岡 京子, 藤田 ひとみ, 神谷 真有美, 近藤 文, 日本公衆衛生学会総会抄録集, 71回,   2012年10月
  • 医学生の喫煙に関する調査より 成人後の喫煙可能性と防煙の必要性について, 神谷 真有美, 鈴木 貞夫, 小嶋 雅代, 岡 京子, 藤田 ひとみ, 近藤 文, 酒井 美奈, 日本公衆衛生学会総会抄録集, 71回,   2012年10月
  • 医学生の喫煙に関する調査より 喫煙に対する意識と知識の関連について, 近藤 文, 鈴木 貞夫, 小嶋 雅代, 岡 京子, 藤田 ひとみ, 神谷 真有美, 酒井 美奈, 日本公衆衛生学会総会抄録集, 71回,   2012年10月
  • 腎結石と慢性腎臓病・心血管疾患リスクに関する臨床疫学研究, 安藤 亮介, 永谷 照男, 鈴木 貞夫, 高橋 英勝, 河合 信, 岡田 淳志, 安井 孝周, 戸澤 啓一, 郡 健二郎, 日本尿路結石症学会誌, 11, (1) 44 - 44,   2012年08月
  • 名古屋市立大学医学部学生の喫煙に対する意識, 鈴木 貞夫, 小嶋 雅代, 岡 京子, 藤田 ひとみ, 神谷 真有美, 近藤 文, 酒井 美奈, 東海公衆衛生学会学術大会抄録集, 58回,   2012年07月
  • 流産経験者の特性についての検討, 藤田ひとみ, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 今枝奈保美, 服部奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, 杉浦眞弓, J Epidemiol, 22,   2012年01月26日
  • 尿路結石の発症に影響をあたえる血清インスリンとインスリン抵抗性に関する臨床疫学研究, 安藤亮介, 安藤亮介, 鈴木貞夫, 永谷照男, 小嶋雅代, 安井孝周, 今枝奈保美, 服部奈美, 柴田清, 後藤千穂, 細野晃弘, 岡田淳志, 山田珠樹, 郡健二郎, 徳留信寛, J Epidemiol, 22,   2012年01月26日
  • 出生体重とメタボリックシンドローム関連疾患既往との関連, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 藤田ひとみ, 今枝奈保美, 服部奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, J Epidemiol, 22,   2012年01月26日
  • ストレスとサプリメント摂取の関連についての横断研究, 荒井健介, 鈴木貞夫, 小嶋雅代, 西山毅, 辻村尚子, 藤田ひとみ, 今枝奈保美, 服部奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, J Epidemiol, 22,   2012年01月26日
  • 地域住民の転倒経験者の特性, 辻村尚子, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 藤田ひとみ, 今枝奈保美, 服部奈美, 柴田清, 後藤千穂, 安藤亮介, 細野晃弘, 深津満, 山田珠樹, 徳留信寛, J Epidemiol, 22,   2012年01月26日
  • 自覚的な幸福感に関連する要因について, 細野晃弘, 細野晃弘, 鈴木貞夫, 小嶋雅代, 西山毅, 荒井健介, 辻村尚子, 藤田ひとみ, 今枝奈保美, 服部奈美, 柴田清, 後藤千穂, 安藤亮介, 深津満, 山田珠樹, 徳留信寛, J Epidemiol, 22,   2012年01月26日
  • 尿路結石の発症に影響をあたえる食習慣とメタボリックシンドロームに関する臨床疫学研究, 安藤 亮介, 藤井 泰普, 岡田 淳志, 安井 孝周, 戸澤 啓一, 郡 健二郎, 鈴木 貞夫, 山田 珠樹, 徳留 信寛, 日本尿路結石症学会誌, 8, (2) 119 - 123,   2011年04月
  • 尿路結石の発症に影響をあたえる血清インスリンとアディポネクチンに関する臨床疫学研究, 安藤 亮介, 鈴木 貞夫, 永谷 照男, 山田 珠樹, 藤井 泰普, 廣瀬 泰彦, 岡田 淳志, 安井 孝周, 秋田 英俊, 戸澤 啓一, 岡村 武彦, 徳留 信寛, 郡 健二郎, 日本泌尿器科学会雑誌, 101, (2) 464 - 464,   2010年02月
  • Insulin-like growth factor (IGF)-I, IGF-II, IGF binding protein-3, and risk of colorectal cancer: a nested case-control study in the Japan collaborative cohort study, Suzuki S, Kojima M, Tokudome S, Suzuki K, Ozasa K, Ito Y, Inaba Y, Tajima K, Nakachi K, Watanabe Y, Tamakoshi A, for the JACC, study group, Asian Pacific Journal of Cancer Prevention, 10,   2009年12月, 査読有り
  • 尿路結石の発症に影響をあたえる食習慣とメタボリックシンドロームに関する臨床疫学研究, 安藤亮介, 鈴木貞夫, 山田珠樹, 藤井泰普, 岡田淳志, 安井孝周, 戸澤啓一, 徳留信寛, 郡健二郎, 日本尿路結石症学会誌, 8,   2009年08月
  • 肥満およびメタボリックシンドロームと尿路結石の関連, 安藤 亮介, 鈴木 貞夫, 山田 珠樹, 小林 隆宏, 岡田 淳志, 安井 孝周, 戸澤 啓一, 徳留 信寛, 郡 健二郎, 日本腎臓学会誌, 51, (6) 802 - 802,   2009年08月
  • Effect of physical activity on breast cancer risk: findings of the Japan Collaborative Cohort Study, Suzuki S, Kojima M, Tokudome S, Mori M, Sakauchi F, Fujino Y, Wakai K, Lin Y, Kikuchi S, Tamakoshi K, Yatsuya H, Tamakoshi A, for the JACC, Study Group, Cancer Epidemiol Biomarkers Prev, 17,   2008年12月, 査読有り
  • A prospective study of educational background and breast cancer among Japanese women, Fujino Y, Mori, M, Tamakoshi A, Sakauchi F, Suzuki S, Wakai K, Tokudome S, Yoshimura T, for the JACC, Study Group, Cancer Causes Control, 19,   2008年11月, 査読有り
  • Active smoking, passive smoking, and breast cancer risk: findings from the Japan Collaborative Cohort Study for Evaluation of Cancer Risk, Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Mori M, Tamakoshi A, for the Japan Collaborative Cohort, Study Group, J Epidemiol, 18,   2008年03月, 査読有り
  • 野菜・果物摂取頻度と乳がんリスクとの関連(Frequency of vegetable consumption and the risk of breast cancer: Findings from the Japan Collaborative Cohort Study), 西尾 和子, 林 櫻松, 鈴木 貞夫, 若井 建志, 久保 達彦, 徳留 信寛, 森 満, 玉腰 暁子, 日本癌学会総会記事, 66回,   2007年08月
  • Dietary fiber and risk of colorectal cancer in the Japan Collaborative Cohort (JACC) Study, Wakai K, Date C, Fukui M, Tamakoshi K, Watanabe Y, Hayakawa N, Kojima M, Kawado M, Suzuki K, Hashimoto S, Tokudome S, Ozasa K, Suzuki S, Toyoshima H, Ito Y, Tamakoshi A for, the JACC, Study Group, Cancer Epidemiol Biomarkers Prev, 16,   2007年04月, 査読有り, コホート研究により、食物繊維摂取が大腸がん、とりわけ結腸がんのリスク低下に関連していることを示した。
  • Psychological attitudes and risk of breast cancer in Japan: a prospective study, Wakai K, Kojima M, Nishio K, Suzuki S, Niwa Y, Lin Y, Kondo T, Yatsuya H, Tamakoshi K, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A for, the JACC, Study Group, Cancer Cause Control, 18,   2007年04月, 査読有り
  • One-carbon metabolism related gene polymorphisms interact with alcohol drinking to influence the risk of colorectal cancer in Japan, K Matsuo, H Ito, K Wakai, K Hirose, T Saito, T Suzuki, T Kato, T Hirai, Y Kanemitsu, H Hamajima, K Tajima, CARCINOGENESIS, 26, (12) 2164 - 2171,   2005年12月, One-carbon metabolism, in which folate plays an essential role, is involved in DNA methylation and synthesis, and is suspected of impacting on colorectal carcinogenesis. Alcohol is well recognized as a risk factor for colorectal cancer (CRC) and interactions with one-carbon metabolism have also been suggested. Therefore, functional polymorphisms in genes encoding members of this pathway, MTHFR C677T and A1298C (genes for methylenetetrahydrofolate reductase), MTR A2756G (gene for methionine synthase) and TS (gene for thymidylate synthase) tandem repeats polymorphisms, have attracted attention. We conducted a matched case-control study with 257 incident CRC cases and 771 non-cancer controls at the Aichi Cancer Center to clarify associations among folate intake and four polymorphisms with reference to CRC risk. Gene-environment interaction between polymorphisms, drinking and folate consumption was also evaluated. None of the polymorphisms showed any significant impact on CRC risk by genotype alone, but when combined with alcohol consumption the MTHFR 677CC type showed a significantly reduced risk (odds ratio (OR) = 0.45, 95% confidence interval (CI): 0.23-0.86) (P = 0.01). MTR GG showed increased risk only among drinkers (OR = 3.35, 1.40-8.05) (P = 0.047). TS polymorphism did not show statistical significance by genotype alone, while interaction with drinking was significant (P = 0.028). The association was not changed even after stratification by daily folate consumption and drinking habit. In conclusion, we found consistently significant interactions between one-carbon metabolism-related polymorphisms and alcohol drinking.
  • Relationship between body mass index and the risk of ovarian cancer in the Japanese population: Findings from the Japanese Collaborate Cohort (JACC) study, Niwa Y, Yatsuya H, Tamakoshi K, Nishio K, Kondo T, Lin Y, Suzuki S, Wakai K, Tokudome S, Yamamoto A, Hamajima N, Toyoshima H, Tamakoshi A for, the JACC, Study Group, J Obstet Gynaecol Res, 31,   2005年10月, 査読有り
  • Prospective study of alcohol consumption and breast cancer risk in Japanese women, Lin Y, Kikuchi S, Tamakoshi K, Wakai K, Kondo T, Niwa Y, Yatsuya H, Nishio K, Suzuki S, Tokudome S, Yamamoto A, Toyoshima H, Tamakoshi A for, the JACC, Study Group, Int J Cancer, 116,   2005年09月20日, 査読有り
  • Body mass indexと卵巣癌罹患リスクの関連, 丹羽 慶光, 八谷 寛, 玉腰 浩司, 西尾 和子, 林 櫻松, 鈴木 貞夫, 若井 建志, 徳留 信寛, 豊嶋 英明, 玉腰 暁子, 日本癌学会総会記事, 64回,   2005年09月
  • 食物繊維摂取と大腸がん罹患リスクとの関連 日本における大規模コホート研究による検討, 若井 建志, 小嶋 雅代, 玉腰 浩司, 渡邊 能行, 早川 式彦, 鈴木 康司, 橋本 修二, 徳留 信寛, 小笹 晃太郎, 鈴木 貞夫, 豊嶋 英明, 伊藤 宜則, 玉腰 暁子, 日本癌学会総会記事, 64回,   2005年09月
  • Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan, CX Yang, K Matsuo, H Ito, M Shinoda, S Hatooka, K Hirose, K Wakai, T Saito, T Suzuki, T Maeda, K Tajima, CARCINOGENESIS, 26, (7) 1285 - 1290,   2005年07月, Folate takes part in two biological pathways involved in DNA methylation and synthesis, and a potential protective influence 4 this nutrient chemical against carcinogenicity has been recognized in several sites, including the esophagus. Therefore, the functional polymorphisms in genes encoding folate metabolizing enzymes, MTHFR C677T and MTR A2756G, might be suspected of impacting on esophageal cancer risk. We therefore conducted a matched case-control study of 165 esophageal cancer cases and 495 non-cancer controls to clarify associations among folate intake, MTHFR C677T and MTR A2756G polymorphisms, and esophageal cancer risk. Gene-environment interactions between the two polymorphisms, and drinking and smoking were also evaluated. Folate consumption and MTHFR 677TT were associated with a non-significant tendency for decreased risk while the MTR genotypes did not show any links in themselves; further, when analysis was limited to heavy drinkers, the MTHFR TT genotype significantly decreased esophageal cancer risk [odds ratio (OR) = 0.27, 95% confidence interval (CI), 0.09-0.76]. The OR for the gene-environment interaction between heavy drinking and the 677TT genotype in the case-only design was 0.31 (95% CI, 0.10-0.94), indicating risk with heavy drinking to be 69% decreased in individuals harboring the 677TT genotype. We failed to find any significant interaction between either of the polymorphisms and smoking.
  • Impact of menstrual and reproductive factors on breast cancer risk in Japan: results of the JACC Study, Tamakoshi K, Yatsuya H, Wakai K, Suzuki S, Nishio K, Lin Y, Niwa Y, Kondo T, Yamamoto A, Tokudome S, Toyoshima H, Tamakoshi A for, the JACC, Study Group, Cancer Sci, 96,   2005年01月, 査読有り
  • 大豆製品摂取と乳がん罹患リスクとの関連, 西尾 和子, 玉腰 浩司, 八谷 寛, 鈴木 貞夫, 徳留 信寛, 丹羽 慶光, 林 櫻松, 豊嶋 英明, 若井 建志, 玉腰 暁子, 日本癌学会総会記事, 63回,   2004年09月
  • 脂質摂取と乳がん罹患リスクとの関連 日本における大規模コホート研究による検討, 若井 建志, 玉腰 浩司, 八谷 寛, 鈴木 貞夫, 徳留 信寛, 丹羽 慶光, 西尾 和子, 林 櫻松, 豊嶋 英明, 玉腰 暁子, 日本癌学会総会記事, 63回,   2004年09月
  • 生殖歴と乳がん罹患リスクとの関連, 玉腰 浩司, 豊嶋 英明, 若井 建志, 林 櫻松, 鈴木 貞夫, 丹羽 慶光, 西尾 和子, 八谷 寛, 徳留 信寛, 玉腰 暁子, 大規模コホート運営委員会, 日本癌学会総会記事, 63回,   2004年09月
  • 喫煙と卵巣癌罹患リスクの関連, 丹羽 慶光, 西尾 和子, 豊嶋 英明, 玉腰 浩司, 八谷 寛, 林 櫻松, 若井 建志, 徳留 信寛, 鈴木 貞夫, 玉腰 暁子, 日本癌学会総会記事, 63回,   2004年09月
  • 飲酒と女性乳がん罹患リスクの関連, 林 櫻松, 菊地 正悟, 豊嶋 英明, 玉腰 浩司, 八谷 寛, 若井 建志, 鈴木 貞夫, 西尾 和子, 徳留 信寛, 玉腰 暁子, 柳生 聖子, 小幡 由紀, 日本癌学会総会記事, 63回,   2004年09月
  • 血清IgEと大腸がんリスクとの関連 文科省科研費の補助による大規模コホート内症例対照研究, 鈴木 康司, 伊藤 宜則, 若井 建志, 小嶋 雅代, 玉腰 浩司, 豊嶋 英明, 渡邊 能行, 早川 式彦, 徳留 信寛, 橋本 修二, 鈴木 貞夫, 小笹 晃太郎, 玉腰 暁子, 日本癌学会総会記事, 63回,   2004年09月
  • Lack of association between DNA base excision repair gene XRCC1 Gln399Arg polymorphism and risk of malignant lymphoma in Japan, K Matsuo, N Hamajima, R Suzuki, M Andoh, S Nakamura, M Seto, Y Morishima, K Tajima, CANCER GENETICS AND CYTOGENETICS, 149, (1) 77 - 80,   2004年02月, Growing evidence suggests that the polymorphism of DNA base excision repair gene XRCC1 Ar-399Gln is associated with altered DNA repair proficiency and subsequent cancer susceptibility; however, no evidence is available for malignant lymphoma. We therefore conducted a case-control study (372 cases, 500 controls) to evaluate links with malignant lymphoma risk in Japan. The risk was evaluated in terms of odds ratio (OR) and 95% confidence interval (CI) adjusted for age and sex in an unconditional logistic regression model. There was no statistical risk change with the Ara/Gln (adjusted OR 0.89; 0.65-1.23, P = 0.492) or the Gln/Gln (0.57; 0.27-1.17, P = 0.127) compared with the Arg/Arg of the XRCC1 Arg399Gln polymorphism. The results were unchanged in analyses according to histological subtype (diffuse large lymphoma, follicular lymphoma, low-Grade lymphoma of mucosa-associated lymphoid tissue, and others). These data suggest that XRCC1 Gln399Arg polymorphism plays a limited role in lymphomagenesis. Further study on the interaction between the polymorphism and environmental exposure is required. (C) 2004 Elsevier Inc. All rights reserved.
  • Smoking and polymorphisms of fucosyltransferase gene Le affect success of H-pylori eradication with lansoprazole, amoxicillin, and clarithromycin, K Matsuo, N Hamajima, Y Ikehara, T Suzuki, T Nakamura, A Matsuura, K Tajima, S Tominaga, EPIDEMIOLOGY AND INFECTION, 130, (2) 227 - 233,   2003年04月, Identification of factors influencing success of Helicobacter pylori (HP) eradication is important for clinical practice. We have prospectively conducted an HP eradication study in the Aichi Cancer Center with a total of 142 patients available for analysis. The overall success rate was 61(.)3 % (95 % confidence interval 52(.)7-69(.)3 %). Smoking during the medication for eradication significantly decreased the success rate (42(.)9 %), whereas smoking cessation during the treatment was associated with a similar rate as for non-smokers (66(.)7 %). We also examined links between an eradication outcome and polymorphisms of Le, Se, IL1A, IL1B, IL1RN and MPO genes, but with one exception none showed any association. The non-functional le allele of Le polymorphisms, leading to decreased expression of Le(b) antigen to which HP attaches with adhesin, showed a beneficial effect for success. Although further clarification is necessary, our study indicated that smoking cessation and Le gene polymorphisms may affect the success rate of HP eradication.
  • Serum antioxidants and subsequent mortality rates of all causes or cancer among rural Japanese inhabitants, Y Ito, K Suzuki, S Suzuki, R Sasaki, M Otani, K Aoki, INTERNATIONAL JOURNAL FOR VITAMIN AND NUTRITION RESEARCH, 72, (4) 237 - 250,   2002年07月, 査読有り, The purpose of this study was to investigate whether a relationship exists between mortality rates and serum antioxidant levels among Japanese inhabitants. The follow-up subjects, who participated in comprehensive health examinations, consisted of 2444 inhabitants (949 males and 1495 females) of a rural area in Hokkaido, Japan. Between 1991 and December 2000, 146 subjects (94 males and 52 females) died, with cancer accounting for 76 of these deaths (48 males and 28 females). Serum samples at fasting were collected at entry into the study, and serum levels of beta- and alpha-carotenes, lycopene, beta-cryptoxanthin, canthaxanthin, zeaxanthin/lutein, tocopherols, and retinol were measured separately by high-performance liquid chromatography (HPLC). The statistical analyses were conducted using the Cox proportional hazard model. Age- and gender-adjusted hazard ratios of the groups with high serum levels of lycopene, beta-carotene, zeaxanthin/lutein, and total carotenoids compared to those with low serum levels were 0.36 (95% C.I: 0.19-0.69), 0.53 (0.29-0.95), 0.73 (0.43-1.25), and 0.52 (0.30-0.92) for cancers of all sites, and 0.44 (95% C.I: 0.28-0.69), 0.59 (0.39-0.90), 0.61 (0.40-0.93), and 0.50 (0.33-0.76) for all causes, respectively. Similar results were found after adjusting for gender, age, smoking habits, alcohol consumption, and serum levels of total cholesterol and glutamic pyruvic transaminase (GPT) activity. Moreover, after excluding mortality within the first three years of follow-up, the hazard ratios of subjects with high serum levels of lycopene, total carotenes, and total carotenoids were significantly and inversely associated with subsequent mortality from all causes and cancers of all sites after adjusting for gender, age, and serum levels of total cholesterol, alpha-tocopherol, and retinol. These results suggest that high serum levels of antioxidants, such as lycopene, beta-carotene and zeaxanthin/lutein, play roles in preventing death from cancer and from all causes. However, high serum levels of tocopherols and retinol did not demonstrate clear associations with either low mortality rates from all causes or cancer of all sites.
  • 某地域住民における血清抗酸化及び酸化物質と死亡及び相互の関連性, 伊藤 宜則, 鈴木 康司, 鈴木 貞夫, 篠原 力雄, 佐々木 隆一郎, 青木 國雄, ビタミン, 75, (4) 221 - 221,   2001年04月
  • Relationship between serum carotenoid levels and cancer death rates in the residents, living in a rural area of Hokkaido, Japan, Ito Y, Suzuki S, Yagyu K, Sasaki R, Suzuki K, Aoki K, Journal of Epidemiaology, 7, (1) 1 - 8,   1997年01月, 査読有り
  • A case-control study of breast cancer among Japanese women in Tokyo, Wakai K, Ohno Y, Suzuki S, Watanabe S, Sakamoto G, Kubo N, Med J Indones, 4,   1995年07月, 査読有り
  • わが国の甲状腺悪性腫瘍死亡の記述疫学特性, 中村利恵, 大野良之, 玉腰暁子, 川村孝, 鈴木貞夫, 若井建志, 黒石哲生, 厚生の指標, 41,   1994年11月
  • Risk factors for breast cancer among Japanese women in Tokyo : a case-control study, Wakai K, Ohno Y, Watanabe S, Sakamoto G, Kasumi F, Suzuki S, Kubo-Fujiwara N, J Epidemiol, 4,   1994年08月, 査読有り
  • 血清総コレステロール値とがん発生・死亡に関する疫学的考察-全部位がんについての追跡調査研究成績総括-, 玉腰暁子, 大野良之, 鈴木貞夫, 川村孝, 若井建志, 中村利恵, 日本公衛誌, 41,   1994年05月15日, 査読有り
  • Serum cholesterol and cancer mortality in Japanese civil service workers : findings from a nested case-control study, Tamakoshi A, Ohno Y, Yamada T, Aoki K, Kawamura T, Suzuki S, Wakai K, Nakamura R, J Epidemiol, 3,   1993年12月, 査読有り

受賞

  •   2006年, 日本疫学会奨励賞

競争的資金

  • 飲酒が心理社会的アウトカムに及ぼす因果効果を確証する網羅的メンデルランダム化研究, 日本学術振興会研究費(基盤研究C),   2019年04月 - 2022年03月
  • 学術研究支援基盤形成「コホート・生体試料支援プラットフォーム」, 日本学術振興会科学研究費(新学術領域研究),   2016年04月 - 2022年03月
  • 大腸がん超高危険度群におけるがんリスク低減手法の最適化に関する研究, 革新的がん医療実用化研究事業受託研究,   2017年04月 - 2020年03月
  • 生活習慣・病態・遺伝的多型に基づく、個人のがんリスク評価:大規模ゲノムコホート研究データの解析, 日本医療研究開発機構受託研究費,   2017年04月 - 2020年03月
  • 精神、心理、社会的要因に焦点を当てたゲノムコホート研究, 日本学術振興会科学研究費(基盤研究B),   2014年04月 - 2019年03月
  • 地域住民の慢性萎縮性胃炎の記述疫学とその肥満や生活習慣病との関連についての研究, 日本学術振興会科学研究費補助金(基盤研究C),   2011年04月 - 2014年03月
  • インスリン抵抗性とメタボリックシンドロームに関する疫学研究, 日本学術振興会科学研究費(基盤研究C),   2007年04月 - 2010年03月
  • 集団検診での糖尿病の効率的な発見のための指標についての検討, 日本学術振興会科学研究費(基盤研究C),   2004年04月 - 2007年03月

教育活動情報

担当経験のある科目

  • 社会医学基礎・応用(公衆衛生学), 名古屋市立大学


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