三田　貴臣 (サンダ　タカオミ)

研究者情報

学位

• PhD（2006年03月 名古屋市立大学）
• MD（2000年03月 名古屋市立大学）

ORCID ID

•  https://orcid.org/0000-0003-1621-4954

J-Global ID

• 202301012539091960

研究キーワード

• 転写因子   エンハンサー   癌遺伝子   T細胞性急性リンパ性白血病   成人T細胞性白血病   神経芽細胞腫   ゼブラフィッシュ   

研究分野

• ライフサイエンス / 血液、腫瘍内科学 / リンパ系腫瘍
• ライフサイエンス / 腫瘍生物学 / 転写因子異常
• ライフサイエンス / 分子生物学 / 転写制御
• ライフサイエンス / ゲノム生物学 / 癌遺伝子、癌抑制遺伝子

経歴

• 2023年09月 - 現在  名古屋市立大学大学院医学研究科 血液・腫瘍内科学分野准教授
• 2020年01月 - 2023年08月  シンガポール国立大学内科学准教授
• 2013年07月 - 2023年08月  シンガポール国立大学シンガポール癌科学研究所主任研究員
• 2013年07月 - 2019年12月  シンガポール国立大学内科学助教
• 2010年01月 - 2013年03月  ハーバード大学医学部ダナファーバー癌研究所インストラクター
• 2006年10月 - 2009年12月  ハーバード大学医学部ダナファーバー癌研究所研究員
• 2002年04月 - 2003年03月  名古屋第一赤十字病院血液内科研修生
• 2000年04月 - 2002年03月  名古屋市立大学病院研修医

学歴

• 2002年04月 - 2006年03月   名古屋市立大学   大学院医学研究科
• 1994年04月 - 2000年03月   名古屋市立大学   医学部

所属学協会

• American Society of Hematology   American Association for Cancer Research   日本癌学会   日本血液学会   日本内科学会   

研究活動情報

論文

• Deciphering the regulatory landscape of murine splenic response to anemic stress at single-cell resolution

  Chong Yang; Rui Yokomori; Lee Hui Chua; Shi Hao Tan; Mun Yee Koh; Haruhito Totani; Takaomi Sanda; Toshio Suda

  Blood Advances 8 7 1651 - 1666 2024年03月
• ASCL1 characterizes adrenergic neuroblastoma via its pioneer function and cooperation with core regulatory circuit factors

  Lu Wang; Tze King Tan; Hyoju Kim; Dennis Kappei; Shi Hao Tan; A. Thomas Look; Takaomi Sanda

  Cell Reports 42 12 113541 - 113541 2023年12月
• Super-enhancer-driven TOX2 mediates oncogenesis in Natural Killer/T Cell Lymphoma

  Jianbiao Zhou; Sabrina Hui Min Toh; Tze King Tan; Kalpnaa Balan; Jing Quan Lim; Tuan Zea Tan; Sinan Xiong; Yunlu Jia; Siok Bian Ng; Yanfen Peng; Anand D. Jeyasekharan; Shuangyi Fan; Soon Thye Lim; Chin Ann Johnny Ong; Choon Kiat Ong; Takaomi Sanda; Wee Joo Chng

  Molecular Cancer 22 1 2023年12月
• Clinical landscape of TP73 structural variants in ATL patients

  Hiroaki Hiramatsu; Rui Yokomori; Liu Shengyi; Norio Tanaka; Seiichi Mori; Kazuma Kiyotani; Osamu Gotoh; Shigeru Kusumoto; Nobuaki Nakano; Youko Suehiro; Asahi Ito; Ilseung Choi; Eiichi Ohtsuka; Michihiro Hidaka; Kisato Nosaka; Makoto Yoshimitsu; Yoshitaka Imaizumi; Shinsuke Iida; Atae Utsunomiya; Tetsuo Noda; Hiroyoshi Nishikawa; Ryuzo Ueda; Takaomi Sanda; Takashi Ishida

  Leukemia 2023年10月
• Targeting dual oncogenic machineries driven by TAL1 and PI3K-AKT pathways in T-cell acute lymphoblastic leukemia

  Fang Qi Lim; Allison Si Yu Chan; Rui Yokomori; Xiao Zi Huang; Madelaine Skolastika Theardy; Allen Eng Juh Yeoh; Shi Hao Tan; Takaomi Sanda

  Haematologica 108 2 367 - 381 2023年02月
• Case report: Genomic analysis of a therapy-related chronic myelomonocytic leukemia with KMT2A rearrangement that progressed to acute myeloid leukemia with acute promyelocytic leukemia-like features

  Tomotaka Suzuki; Rui Yokomori; Takaomi Sanda; Takaki Kikuchi; Yoshiaki Marumo; Shiori Kinoshita; Tomoko Narita; Ayako Masaki; Asahi Ito; Masaki Ri; Shigeru Kusumoto; Hirokazu Komatsu; Hiroshi Inagaki; Shinsuke Iida

  Frontiers in Oncology 13 2023年
• TAL1 hijacks MYCN enhancer that induces MYCN expression and dependence on mevalonate pathway in T-cell acute lymphoblastic leukemia

  Shi Hao Tan; Tze King Tan; Rui Yokomori; Minghui Liao; Xiao Zi Huang; Allen Eng Juh Yeoh; Takaomi Sanda

  Leukemia 2023年
• Mitochondria transfer mediates stress erythropoiesis by altering the bioenergetic profiles of early erythroblasts through CD47

  Chong Yang; Rui Yokomori; Lee Hui Chua; Shi Hao Tan; Darren Qiancheng Tan; Kenichi Miharada; Takaomi Sanda; Toshio Suda

  Journal of Experimental Medicine 219 12 2022年12月
• IRF4 drives clonal evolution and lineage choice in a zebrafish model of T-cell lymphoma

  Stella Amanda; Tze King Tan; Jolynn Zu Lin Ong; Madelaine Skolastika Theardy; Regina Wan Ju Wong; Xiao Zi Huang; Muhammad Zulfaqar Ali; Yan Li; Zhiyuan Gong; Hiroshi Inagaki; Ee Yong Foo; Brendan Pang; Soo Yong Tan; Shinsuke Iida; Takaomi Sanda

  Nature Communications 13 1 2022年12月
• A Myb enhancer-guided analysis of basophil and mast cell differentiation

  Takayoshi Matsumura; Haruhito Totani; Yoshitaka Gunji; Masahiro Fukuda; Rui Yokomori; Jianwen Deng; Malini Rethnam; Chong Yang; Tze King Tan; Tadayoshi Karasawa; Kazuomi Kario; Masafumi Takahashi; Motomi Osato; Takaomi Sanda; Toshio Suda

  Nature Communications 13 1 2022年12月
• Lineage- and Stage-Specific Oncogenicity of IRF4

  Stella Amanda; Tze King Tan; Shinsuke Iida; Takaomi Sanda

  Experimental Hematology 114 9 - 17 2022年10月
• Loss of METTL3 attenuates blastic plasmacytoid dendritic cell neoplasm response to PRMT5 inhibition via IFN signaling

  Malini Rethnam; Darren Qiancheng Tan; Shi Hao Tan; Jia Li; Rui Yokomori; Ying Li; Henry Yang; Takaomi Sanda; Toshio Suda

  Blood Advances 6 18 5330 - 5344 2022年09月
• Requirement for TP73 and genetic alterations originating from its intragenic super-enhancer in adult T-cell leukemia

  Jolynn Zu Lin Ong; Rui Yokomori; Regina Wan Ju Wong; Tze King Tan; Ryuzo Ueda; Takashi Ishida; Shinsuke Iida; Takaomi Sanda

  Leukemia 36 9 2293 - 2305 2022年09月
• IRF4 as an Oncogenic Master Transcription Factor

  Regina Wan Ju Wong; Jolynn Zu Lin Ong; Madelaine Skolastika Theardy; Takaomi Sanda

  Cancers 14 17 2022年09月
• Editorial: Neuroblastoma: Signal Crosstalk and Future Insight Into Clinical Trials

  Kiyohiro Ando; Takaomi Sanda; Yusuke Suenaga; Tao Liu

  Frontiers in Oncology 12 2022年03月
• Super Enhancer-Mediated Upregulation of HJURP Promotes Growth and Survival of t(4;14)-Positive Multiple Myeloma

  Yunlu Jia; Jianbiao Zhou; Tze King Tan; Tae Hoon Chung; Yongxia Chen; Jing Yuan Chooi; Takaomi Sanda; Melissa J. Fullwood; Sinan Xiong; Sabrina H.M. Toh; Kalpnaa Balan; Regina W.J. Wong; Julia S.L. Lim; Enfan Zhang; Zhen Cai; Peng Shen; Wee Joo Chng

  Cancer Research 82 3 406 - 418 2022年02月
• Germline RUNX1 variation and predisposition to childhood acute lymphoblastic leukemia

  Yizhen Li; Wentao Yang; Meenakshi Devidas; Stuart S. Winter; Chimene Kesserwan; Wenjian Yang; Kimberly P. Dunsmore; Colton Smith; Maoxiang Qian; Xujie Zhao; Ranran Zhang; Julie M. Gastier-Foster; Elizabeth A. Raetz; William L. Carroll; Chunliang Li; Paul P. Liu; Karen R. Rabin; Takaomi Sanda; Charles G. Mullighan; Kim E. Nichols; William E. Evans; Ching Hon Pui; Stephen P. Hunger; David T. Teachey; Mary V. Relling; Mignon L. Loh; Jun J. Yang

  Journal of Clinical Investigation 131 17 2021年09月
• Oncorequisite role of an aldehyde dehydrogenase in the pathogenesis of T-cell acute lymphoblastic leukemia

  Chujing Zhang; Stella Amanda; Cheng Wang; Tze King Tan; Muhammad Zulfaqar Ali; Wei Zhong Leong; Ley Moy Ng; Shojiro Kitajima; Zhenhua Li; Allen Eng Juh Yeoh; Shi Hao Tan; Takaomi Sanda

  Haematologica 106 6 1545 - 1558 2021年06月
• Super-enhancers for RUNX3 are required for cell proliferation in EBV-infected B cell lines

  Hiroki Hosoi; Akiko Niibori-Nambu; Giselle Sek Suan Nah; Avinash Govind Bahirvani; Michelle Meng Huang Mok; Takaomi Sanda; Alan Prem Kumar; Daniel G. Tenen; Yoshiaki Ito; Takashi Sonoki; Motomi Osato

  Gene 774 2021年03月
• Myeloma-specific superenhancers affect genes of biological and clinical relevance in myeloma

  Yunlu Jia; Jianbiao Zhou; Tze King Tan; Tae Hoon Chung; Regina Wan Ju Wong; Jing Yuan Chooi; Julia Sze Lynn Lim; Takaomi Sanda; Melissa Ooi; Sanjay De Mel; Cinnie Soekojo; Yongxia Chen; Enfan Zhang; Zhen Cai; Peng Shen; Jian Ruan; Wee Joo Chng

  Blood Cancer Journal 11 2 2021年02月
• ESRRB regulates glucocorticoid gene expression in mice and patients with acute lymphoblastic leukemia

  Kayleigh M. Gallagher; Justine E. Roderick; Shi Hao Tan; Tze King Tan; Leonard Murphy; Jun Yu; Rui Li; Kevin W. O'Connor; Julie Zhu; Michael R. Green; Takaomi Sanda; Michelle A. Kelliher

  Blood Advances 4 13 3154 - 3168 2020年07月
• Feed-forward regulatory loop driven by IRF4 and NF-κB in adult T-cell leukemia/lymphoma

  Regina Wan Ju Wong; Tze King Tan; Stella Amanda; Phuong Cao Thi Ngoc; Wei Zhong Leong; Shi Hao Tan; Kaori Asamitsu; Yurina Hibi; Ryuzo Ueda; Takashi Okamoto; Takashi Ishida; Shinsuke Iida; Takaomi Sanda

  Blood 135 12 934 - 947 2020年03月
• Sphingosine 1-phosphate receptor 2 induces otoprotective responses to cisplatin treatment

  Wei Wang; Muthu K. Shanmugam; Ping Xiang; Ting Yu Amelia Yam; Vineet Kumar; Wee Siong Chew; Jing Kai Chang; Muhammad Zulfaqar Bin Ali; Marie J.Y. Reolo; Yee Xin Peh; Siti Nasuha Binte Abdul Karim; Andrew Y.Y. Tan; Takaomi Sanda; Gautam Sethi; Deron R. Herr

  Cancers 12 1 2020年01月
• Genome-Wide Association Study of Susceptibility Loci for T-Cell Acute Lymphoblastic Leukemia in Children

  Maoxiang Qian; Xujie Zhao; Meenakshi Devidas; Wenjian Yang; Yoshihiro Gocho; Colton Smith; Julie M. Gastier-Foster; Yizhen Li; Heng Xu; Shouyue Zhang; Sima Jeha; Xiaowen Zhai; Takaomi Sanda; Stuart S. Winter; Kimberly P. Dunsmore; Elizabeth A. Raetz; William L. Carroll; Naomi J. Winick; Karen R. Rabin; Patrick A. Zweidler-Mckay; Brent Wood; Ching Hon Pui; William E. Evans; Stephen P. Hunger; Charles G. Mullighan; Mary V. Relling; Mignon L. Loh; Jun J. Yang

  Journal of the National Cancer Institute 111 12 1350 - 1357 2019年12月
• ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

  Lu Wang; Tze King Tan; Adam D. Durbin; Mark W. Zimmerman; Brian J. Abraham; Shi Hao Tan; Phuong Cao Thi Ngoc; Nina Weichert-Leahey; Koshi Akahane; Lee N. Lawton; Jo Lynne Rokita; John M. Maris; Richard A. Young; A. Thomas Look; Takaomi Sanda

  Nature Communications 10 1 2019年12月
• The enhancer RNA ARIEL activates the oncogenic transcriptional program in T-cell acute lymphoblastic leukemia

  Shi Hao Tan; Wei Zhong Leong; Phuong Cao Thi Ngoc; Tze King Tan; Fatima Carla Bertulfo; Mei Chee Lim; Omer An; Zhenhua Li; Allen Eng Juh Yeoh; Melissa J. Fullwood; Daniel G. Tenen; Takaomi Sanda

  Blood 134 3 239 - 251 2019年07月
• Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma

  Nicole Prutsch; Elisabeth Gurnhofer; Tobias Suske; Huan Chang Liang; Michaela Schlederer; Simone Roos; Lawren C. Wu; Ingrid Simonitsch-Klupp; Andrea Alvarez-Hernandez; Christoph Kornauth; Dario A. Leone; Jasmin Svinka; Robert Eferl; Tanja Limberger; Astrid Aufinger; Nitesh Shirsath; Peter Wolf; Thomas Hielscher; Fritz Aberger; Johannes Schmoellerl; Dagmar Stoiber; Birgit Strobl; Ulrich Jäger; Philipp B. Staber; Florian Grebien; Richard Moriggl; Mathias Müller; Giorgio G. Inghirami; Takaomi Sanda; A. Thomas Look; Suzanne D. Turner; Lukas Kenner; Olaf Merkel

  Leukemia 33 3 696 - 709 2019年03月
• Oncogenic transcriptional program driven by TAL1 in T-cell acute lymphoblastic leukemia

  Tze King Tan; Chujing Zhang; Takaomi Sanda

  International Journal of Hematology 109 1 5 - 17 2019年01月
• Cyclin-dependent kinase 9 as a potential specific molecular target in NK-cell leukemia/lymphoma

  Shiori Kinoshita; Takashi Ishida; Asahi Ito; Tomoko Narita; Ayako Masaki; Susumu Suzuki; Takashi Yoshida; Masaki Ri; Shigeru Kusumoto; Hirokazu Komatsu; Norio Shimizu; Hiroshi Inagaki; Taruho Kuroda; Arne Scholz; Ryuzo Ueda; Takaomi Sanda; Shinsuke Iida

  Haematologica 103 12 2059 - 2068 2018年11月
• Identification of novel lncRNAs regulated by the TAL1 complex in T-cell acute lymphoblastic leukemia

  Phuong Cao Thi Ngoc; Shi Hao Tan; Tze King Tan; Min Min Chan; Zhenhua Li; Allen E.J. Yeoh; Daniel G. Tenen; Takaomi Sanda

  Leukemia 32 10 2138 - 2151 2018年10月
• JDP2: An oncogenic bZIP transcription factor in T cell acute lymphoblastic leukemia

  Marc R. Mansour; Shuning He; Zhaodong Li; Riadh Lobbardi; Brian J. Abraham; Clemens Hug; Sunniyat Rahman; Theresa E. Leon; You Yi Kuang; Mark W. Zimmerman; Traci Blonquist; Evisa Gjini; Alejandro Gutierrez; Qin Tang; Laura Garcia‑Perez; Karin Pike‑Overzet; Lars Anders; Alla Berezovskaya; Yi Zhou; Leonard I. Zon; Donna Neuberg; Adele K. Fielding; Frank J.T. Staal; David M. Langenau; Takaomi Sanda; Richard A. Young; A. Thomas Look

  Journal of Experimental Medicine 215 7 1929 - 1945 2018年07月
• Targeting general transcriptional machinery as a therapeutic strategy for adult T-cell leukemia

  Regina Wan Ju Wong; Takashi Ishida; Takaomi Sanda

  Molecules 23 5 2018年
• ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis

  Wei Zhong Leong; Shi Hao Tan; Phuong Cao Thi Ngoc; Stella Amanda; Alice Wei Yee Yam; Wei Siang Liau; Zhiyuan Gong; Lee N. Lawton; Daniel G. Tenen; Takaomi Sanda

  Genes and Development 31 23-24 2343 - 2360 2017年12月
• Enhancer profiling identifies critical cancer genes and characterizes cell identity in adult T-cell leukemia

  Regina Wan Ju Wong; Phuong Cao Thi Ngoc; Wei Zhong Leong; Alice Wei Yee Yam; Tinghu Zhang; Kaori Asamitsu; Shinsuke Iida; Takashi Okamoto; Ryuzo Ueda; Nathanael S. Gray; Takashi Ishida; Takaomi Sanda

  Blood 130 21 2326 - 2338 2017年11月
• RUNX1 in T-ALL: Tumor suppressive or oncogenic?

  Takaomi Sanda

  Blood 130 15 1686 - 1688 2017年10月
• APOBEC signature mutation generates an oncogenic enhancer that drives LMO1 expression in T-ALL

  Z. Li; B. J. Abraham; A. Berezovskaya; N. Farah; Y. Liu; T. Leon; A. Fielding; S. H. Tan; T. Sanda; A. S. Weintraub; B. Li; S. Shen; J. Zhang; M. R. Mansour; R. A. Young; A. T. Look

  Leukemia 31 10 2057 - 2064 2017年10月
• Leukemia-initiating cells in T-cell acute lymphoblastic leukemia

  Shi Hao Tan; Fatima Carla Bertulfo; Takaomi Sanda

  Frontiers in Oncology 7 SEP 2017年09月
• TAL1 as a master oncogenic transcription factor in T-cell acute lymphoblastic leukemia

  Takaomi Sanda; Wei Zhong Leong

  Experimental Hematology 53 7 - 15 2017年09月
• Aberrant activation of the GIMAP enhancer by oncogenic transcription factors in T-cell acute lymphoblastic leukemia

  W. S. Liau; S. H. Tan; P. C.T. Ngoc; C. Q. Wang; V. Tergaonkar; H. Feng; Z. Gong; M. Osato; A. T. Look; T. Sanda

  Leukemia 31 8 1798 - 1807 2017年08月
• Anti-leukaemic activity of the TYK2 selective inhibitor NDI-031301 in T-cell acute lymphoblastic leukaemia

  Koshi Akahane; Zhaodong Li; Julia Etchin; Alla Berezovskaya; Evisa Gjini; Craig E. Masse; Wenyan Miao; Jennifer Rocnik; Rosana Kapeller; Jeremy R. Greenwood; Hong Tiv; Takaomi Sanda; David M. Weinstock; A. Thomas Look

  British Journal of Haematology 177 2 271 - 282 2017年04月
• Roles of the RUNX1 enhancer in normal hematopoiesis and leukemogenesis

  Wei Siang Liau; Phuong Cao Thi Ngoc; Takaomi Sanda

  Advances in Experimental Medicine and Biology 962 139 - 147 2017年
• The TCA cycle transferase DLST is important for MYC-mediated leukemogenesis

  N. M. Anderson; D. Li; H. L. Peng; F. J.F. Laroche; M. R. Mansour; E. Gjini; M. Aioub; D. J. Helman; J. E. Roderick; T. Cheng; I. Harrold; Y. Samaha; L. Meng; A. Amsterdam; D. S. Neuberg; T. T. Denton; T. Sanda; M. A. Kelliher; A. Singh; A. T. Look; H. Feng

  Leukemia 30 6 1365 - 1374 2016年06月
• TRIB2 reinforces the oncogenic transcriptional program controlled by the TAL1 complex in T-cell acute lymphoblastic leukemia

  S. H. Tan; A. W.Y. Yam; L. N. Lawton; R. W.J. Wong; R. A. Young; A. T. Look; T. Sanda

  Leukemia 30 4 959 - 962 2016年04月
• The KDM3A-KLF2-IRF4 axis maintains myeloma cell survival

  Hiroto Ohguchi; Teru Hideshima; Manoj K. Bhasin; Gullu T. Gorgun; Loredana Santo; Michele Cea; Mehmet K. Samur; Naoya Mimura; Rikio Suzuki; Yu Tzu Tai; Ruben D. Carrasco; Noopur Raje; Paul G. Richardson; Nikhil C. Munshi; Hideo Harigae; Takaomi Sanda; Juro Sakai; Kenneth C. Anderson

  Nature Communications 7 2016年01月
• HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia

  K. Akahane; T. Sanda; M. R. Mansour; T. Radimerski; D. J. Deangelo; D. M. Weinstock; A. T. Look

  Leukemia 30 1 219 - 228 2016年01月
• Inhibition of wild-type p53-expressing AML by the novel small molecule HDM2 inhibitor CGM097

  Ellen Weisberg; Ensar Halilovic; Vesselina G. Cooke; Atsushi Nonami; Tao Ren; Takaomi Sanda; Irene Simkin; Jing Yuan; Brandon Antonakos; Louise Barys; Moriko Ito; Richard Stone; Ilene Galinsky; Kristen Cowens; Erik Nelson; Martin Sattler; Sebastien Jeay; Jens U. Wuerthner; Sean M. McDonough; Marion Wiesmann; James D. Griffin

  Molecular Cancer Therapeutics 14 10 2249 - 2259 2015年10月
• An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element

  Marc R. Mansour; Brian J. Abraham; Lars Anders; Alla Berezovskaya; Alejandro Gutierrez; Adam D. Durbin; Julia Etchin; Lawton Lee; Stephen E. Sallan; Lewis B. Silverman; Mignon L. Loh; Stephen P. Hunger; Takaomi Sanda; Richard A. Young; A. Thomas Look

  Science 346 6215 1373 - 1377 2014年12月
• Ribonucleoprotein HNRNPA2B1 Interacts with and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells

  Carles Barceló; Julia Etchin; Marc R. Mansour; Takaomi Sanda; Mireia M. Ginesta; Victor J. Sanchez-Arévalo Lobo; Francisco X. Real; Gabriel Capellà; Josep M. Estanyol; Montserrat Jaumot; A. Thomas Look; Neus Agell

  Gastroenterology 147 4 882 - 892.e8 2014年10月
• RUNX1 point mutations potentially identify a subset of early immature T-cell acute lymphoblastic leukaemia that may originate from differentiated T-cells

  Michelle Meng Huang Mok; Linsen Du; Chelsia Qiuxia Wang; Vinay Tergaonkar; Te Chih Liu; Shirley Kow Yin Kham; Takaomi Sanda; Allen Eng Juh Yeoh; Motomi Osato

  Gene 545 1 111 - 116 2014年07月
• BCL2-specific inhibitor ABT-199 synergizes strongly with cytarabine against the early immature LOUCY cell line but not more-differentiated T-ALL cell lines

  N. M. Anderson; I. Harrold; M. R. Mansour; T. Sanda; M. McKeown; N. Nagykary; J. E. Bradner; G. Lan Zhang; A. T. Look; H. Feng

  Leukemia 28 5 1145 - 1148 2014年05月
• Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

  Nicholas Kwiatkowski; Tinghu Zhang; Peter B. Rahl; Brian J. Abraham; Jessica Reddy; Scott B. Ficarro; Anahita Dastur; Arnaud Amzallag; Sridhar Ramaswamy; Bethany Tesar; Catherine E. Jenkins; Nancy M. Hannett; Douglas McMillin; Takaomi Sanda; Taebo Sim; Nam Doo Kim; Thomas Look; Constantine S. Mitsiades; Andrew P. Weng; Jennifer R. Brown; Cyril H. Benes; Jarrod A. Marto; Richard A. Young; Nathanael S. Gray

  Nature 511 7511 616 - 620 2014年
• Molecular rationale for the use of PI3K/AKT/mTOR pathway inhibitors in combination with crizotinib in ALK-mutated neuroblastoma

  Nathan F. Moore; Anna M. Azarova; Namrata Bhatnagar; Kenneth N. Ross; Lauren E. Drake; Stacey Frumm; Qinsong S. Liu; Amanda L. Christie; Takaomi Sanda; Louis Chesler; Andrew L. Kung; Nathanael S. Gray; Kimberly Stegmaier; Rani E. George

  Oncotarget 5 18 8737 - 8749 2014年
• Discovery of a selective irreversible BMX inhibitor for prostate cancer

  Feiyang Liu; Xin Zhang; Ellen Weisberg; Sen Chen; Wooyoung Hur; Hong Wu; Zheng Zhao; Wenchao Wang; Mao Mao; Changmeng Cai; Nicholas I. Simon; Takaomi Sanda; Jinhua Wang; A. Thomas Look; James D. Griffin; Steven P. Balk; Qingsong Liu; Nathanael S. Gray

  ACS Chemical Biology 8 7 1423 - 1428 2013年07月
• TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia

  Takaomi Sanda; Jeffrey W. Tyner; Alejandro Gutierrez; Vu N. Ngo; Jason Glover; Bill H. Chang; Arla Yost; Wenxue Ma; Angela G. Fleischman; Wenjun Zhou; Yandan Yang; Maria Kleppe; Yebin Ahn; Jessica Tatarek; Michelle A. Kelliher; Donna S. Neuberg; Ross L. Levine; Richard Moriggl; Mathias Müller; Nathanael S. Gray; Catriona H.M. Jamieson; Andrew P. Weng; Louis M. Staudt; Brian J. Druker; A. Thomas Look

  Cancer Discovery 3 5 564 - 577 2013年05月
• KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia

  Julia Etchin; Takaomi Sanda; Marc R. Mansour; Alex Kentsis; Joan Montero; Bonnie T. Le; Amanda L. Christie; Dilara Mccauley; Scott J. Rodig; Michael Kauffman; Sharon Shacham; Richard Stone; Anthony Letai; Andrew L. Kung; A. Thomas Look

  British Journal of Haematology 161 1 117 - 127 2013年04月
• Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells

  J. Etchin; Q. Sun; A. Kentsis; A. Farmer; Z. C. Zhang; T. Sanda; M. R. Mansour; C. Barcelo; D. McCauley; M. Kauffman; S. Shacham; A. L. Christie; A. L. Kung; S. J. Rodig; Y. M. Chook; A. T. Look

  Leukemia 27 1 66 - 74 2013年01月
• The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

  Marc R. Mansour; Takaomi Sanda; Lee N. Lawton; Xiaoyu Li; Taras Kreslavsky; Carl D. Novina; Marjorie Brand; Alejandro Gutierrez; Michelle A. Kelliher; Catriona H.M. Jamieson; Harald von Boehmer; Richard A. Young; A. Thomas Look

  Journal of Experimental Medicine 210 8 1545 - 1557 2013年
• The Requirement for Cyclin D Function in Tumor Maintenance

  Yoon Jong Choi; Xiaoyu Li; Per Hydbring; Takaomi Sanda; Joanna Stefano; Amanda L. Christie; Sabina Signoretti; A. Thomas Look; Andrew L. Kung; Harald von Boehmer; Piotr Sicinski

  Cancer Cell 22 4 438 - 451 2012年10月
• Using combination therapy to override stromal-mediated chemoresistance in mutant FLT3-positive AML: Synergism between FLT3 inhibitors, dasatinib/multi-targeted inhibitors and JAK inhibitors

  E. Weisberg; Q. Liu; Erik Nelson; A. L. Kung; A. L. Christie; R. Bronson; M. Sattler; T. Sanda; Z. Zhao; W. Hur; C. Mitsiades; R. Smith; J. F. Daley; R. Stone; I. Galinsky; J. D. Griffin; N. Gray

  Leukemia 26 10 2233 - 2244 2012年10月
• PIDD Death-Domain Phosphorylation by ATM Controls Prodeath versus Prosurvival PIDDosome Signaling

  Kiyohiro Ando; Jennifer L. Kernan; Peter H. Liu; Takaomi Sanda; Emmanuelle Logette; Jurg Tschopp; A. Thomas Look; Jianlong Wang; Lisa Bouchier-Hayes; Samuel Sidi

  Molecular Cell 47 5 681 - 693 2012年09月
• Core Transcriptional Regulatory Circuit Controlled by the TAL1 Complex in Human T Cell Acute Lymphoblastic Leukemia

  Takaomi Sanda; Lee N. Lawton; M. Inmaculada Barrasa; Zi Peng Fan; Holger Kohlhammer; Alejandro Gutierrez; Wenxue Ma; Jessica Tatarek; Yebin Ahn; Michelle A. Kelliher; Catriona H.M. Jamieson; Louis M. Staudt; Richard A. Young; A. Thomas Look

  Cancer Cell 22 2 209 - 221 2012年08月
• The ALK^F1174L Mutation Potentiates the Oncogenic Activity of MYCN in Neuroblastoma

  Teeara Berry; William Luther; Namrata Bhatnagar; Yann Jamin; Evon Poon; Takaomi Sanda; Desheng Pei; Bandana Sharma; Winston R. Vetharoy; Albert Hallsworth; Zai Ahmad; Karen Barker; Lisa Moreau; Hannah Webber; Wenchao Wang; Qingsong Liu; Antonio Perez-Atayde; Scott Rodig; Nai Kong Cheung; Florence Raynaud; Bengt Hallberg; Simon P. Robinson; Nathanael S. Gray; Andrew D.J. Pearson; Suzanne A. Eccles; Louis Chesler; Rani E. George

  Cancer Cell 22 1 117 - 130 2012年07月
• Autocrine activation of the MET receptor tyrosine kinase in acute myeloid leukemia

  Alex Kentsis; Casie Reed; Kim L. Rice; Takaomi Sanda; Scott J. Rodig; Eleni Tholouli; Amanda Christie; Peter J.M. Valk; Ruud Delwel; Vu Ngo; Jeffery L. Kutok; Suzanne E. Dahlberg; Lisa A. Moreau; Richard J. Byers; James G. Christensen; George Vande Woude; Jonathan D. Licht; Andrew L. Kung; Louis M. Staudt; A. Thomas Look

  Nature Medicine 18 7 1118 - 1122 2012年07月
• Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kinetics

  Qingsong Liu; Sivapriya Kirubakaran; Wooyoung Hur; Mario Niepel; Kenneth Westover; Carson C. Thoreen; Jinhua Wang; Jing Ni; Matthew P. Patricelli; Kurt Vogel; Steve Riddle; David L. Waller; Ryan Traynor; Takaomi Sanda; Zheng Zhao; Seong A. Kang; Jean Zhao; A. Thomas Look; Peter K. Sorger; David M. Sabatini; Nathanael S. Gray

  Journal of Biological Chemistry 287 13 9742 - 9752 2012年03月
• The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

  Alejandro Gutierrez; Alex Kentsis; Takaomi Sanda; Linda Holmfeldt; Shann Ching Chen; Jianhua Zhang; Alexei Protopopov; Lynda Chin; Suzanne E. Dahlberg; Donna S. Neuberg; Lewis B. Silverman; Stuart S. Winter; Stephen P. Hunger; Stephen E. Sallan; Shan Zha; Frederick W. Alt; James R. Downing; Charles G. Mullighan; A. Thomas Look

  Blood 118 15 4169 - 4173 2011年10月
• Repression of tumor suppressor miR-451 is essential for NOTCH1-induced oncogenesis in T-ALL

  Xiaoyu Li; Takaomi Sanda; A. Thomas Look; Carl D. Novina; Harald von Boehmer

  Journal of Experimental Medicine 208 4 663 - 675 2011年04月
• T-lymphoblastic lymphoma cells express high levels of BCL2, S1P1, and ICAM1, leading to a blockade of tumor cell intravasation

  Hui Feng; David L. Stachura; Richard M. White; Alejandro Gutierrez; Lu Zhang; Takaomi Sanda; Cicely A. Jette; Joseph R. Testa; Donna S. Neuberg; David M. Langenau; Jeffery L. Kutok; Leonard I. Zon; David Traver; Mark D. Fleming; John P. Kanki; A. Thomas Look

  Cancer Cell 18 4 353 - 366 2010年10月
• Absence of biallelic TCRγ deletion predicts early treatment failure in pediatric T-cell acute lymphoblastic leukemia

  Alejandro Gutierrez; Suzanne E. Dahlberg; Donna S. Neuberg; Jianhua Zhang; Ruta Grebliunaite; Takaomi Sanda; Alexei Protopopov; Valeria Tosello; Jeffery Kutok; Richard S. Larson; Michael J. Borowitz; Mignon L. Loh; Adolfo A. Ferrando; Stuart S. Winter; Charles G. Mullighan; Lewis B. Silverman; Lynda Chin; Stephen P. Hunger; Stephen E. Sallan; A. Thomas Look

  Journal of Clinical Oncology 28 24 3816 - 3823 2010年08月
• ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification

  Shan Zha; Craig H. Bassing; Takaomi Sanda; James W. Brush; Harin Patel; Peter H. Goff; Michael M. Murphy; Suprawee Tepsuporn; Richard A. Gatti; A. Thomas Look; Frederick W. Alt

  Journal of Experimental Medicine 207 7 1369 - 1380 2010年07月
• Phosphatase-dependent and -independent functions of Shp2 in neural crest cells underlie LEOPARD syndrome pathogenesis

  Rodney A. Stewart; Takaomi Sanda; Hans R. Widlund; Shizhen Zhu; Kenneth D. Swanson; Aeron D. Hurley; Mohamed Bentires-Alj; David E. Fisher; Maria I. Kontaridis; A. Thomas Look; Benjamin G. Neel

  Developmental Cell 18 5 750 - 762 2010年05月
• Inactivation of LEF1 in T-cell acute lymphoblastic leukemia

  Alejandro Gutierrez; Takaomi Sanda; Wenxue Ma; Jianhua Zhang; Ruta Grebliunaite; Suzanne Dahlberg; Donna Neuberg; Alexei Protopopov; Stuart S. Winter; Richard S. Larson; Michael J. Borowitz; Lewis B. Silverman; Lynda Chin; Stephen P. Hunger; Catriona Jamieson; Stephen E. Sallan; A. Thomas Look

  Blood 115 14 2845 - 2851 2010年04月
• Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia

  Takaomi Sanda; Xiaoyu Li; Alejandro Gutierrez; Yebin Ahn; Donna S. Neuberg; Jennifer O'Neil; Peter R. Strack; Christopher G. Winter; Stuart S. Winter; Richard S. Larson; Harald Von Boehmer; A. Thomas Look

  Blood 115 9 1735 - 1745 2010年03月
• Emi1 maintains genomic integrity during zebrafish embryogenesis and cooperates with p53 in tumor suppression

  Jennifer Rhodes; Adam Amsterdam; Takaomi Sanda; Lisa A. Moreau; Keith McKenna; Stefan Heinrichs; Neil J. Ganem; Karen W. Ho; Donna S. Neuberg; Adam Johnston; Yebin Ahn; Jeffery L. Kutok; Robert Hromas; Justin Wray; Charles Lee; Carly Murphy; Ina Radtke; James R. Downing; Mark D. Fleming; Laura E. MacConaill; James F. Amatruda; Alejandro Gutierrez; Ilene Galinsky; Richard M. Stone; Eric A. Ross; David S. Pellman; John P. Kanki; A. Thomas Look

  Molecular and Cellular Biology 29 21 5911 - 5922 2009年11月
• High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

  Alejandro Gutierrez; Takaomi Sanda; Ruta Grebliunaite; Arkaitz Carracedo; Leonardo Salmena; Yebin Ahn; Suzanne Dahlberg; Donna Neuberg; Lisa A. Moreau; Stuart S. Winter; Richard Larson; Jianhua Zhang; Alexei Protopopov; Lynda Chin; Pier Paolo Pandolfi; Lewis B. Silverman; Stephen P. Hunger; Stephen E. Sallan; A. Thomas Look

  Blood 114 3 647 - 650 2009年
• Activating mutations in ALK provide a therapeutic target in neuroblastoma

  Rani E. George; Takaomi Sanda; Megan Hanna; Stefan Fröhling; William Luther; Jianming Zhang; Yebin Ahn; Wenjun Zhou; Wendy B. London; Patrick McGrady; Liquan Xue; Sergey Zozulya; Vlad E. Gregor; Thomas R. Webb; Nathanael S. Gray; D. Gary Gilliland; Lisa Diller; Heidi Greulich; Stephan W. Morris; Matthew Meyerson; A. Thomas Look

  Nature 455 7215 975 - 978 2008年10月
• 14q32転座関連遺伝子mRNA発現に基づく病型分類は骨髄腫患者の生命予後予測に有用である

  稲垣 淳; 飯田 真介; 森 芙美子; 伊藤 旭; 田島 恵美; 三田 貴臣; 矢野 寛樹; 李 政樹; 粥川 哲; 丁 建民; 楠本 茂; 石田 高司; 花村 一朗; 速水 芳仁; 小松 弘和; 稲垣 宏; 上田 龍三

  臨床血液 49 9 906 - 906 (一社)日本血液学会-東京事務局 2008年09月
• Chk1 Suppresses a Caspase-2 Apoptotic Response to DNA Damage that Bypasses p53, Bcl-2, and Caspase-3

  Samuel Sidi; Takaomi Sanda; Richard D. Kennedy; Andreas T. Hagen; Cicely A. Jette; Raymond Hoffmans; Jennifer Pascual; Shintaro Imamura; Shuji Kishi; James F. Amatruda; John P. Kanki; Douglas R. Green; Alan A. D'Andrea; A. Thomas Look

  Cell 133 5 864 - 877 2008年05月
• Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for multiple myeloma

  Hiroki Yano; Satoshi Kayukawa; Shinsuke Iida; Chiharu Nakagawa; Tetsuya Oguri; Takaomi Sanda; Jianming Ding; Fumiko Mori; Asahi Ito; Masaki Ri; Atsushi Inagaki; Shigeru Kusumoto; Takashi Ishida; Hirokazu Komatsu; Hiroshi Inagaki; Atsushi Suzuki; Ryuzo Ueda

  Cancer Science 99 11 2309 - 2314 2008年
• Proteome analyses of the growth inhibitory effects of NCH-51, a novel histone deacetylase inhibitor, on lymphoid malignant cells

  T. Sanda; T. Okamoto; Y. Uchida; H. Nakagawa; S. Iida; S. Kayukawa; T. Suzuki; T. Oshizawa; T. Suzuki; N. Miyata; R. Ueda

  Leukemia 21 11 2344 - 2353 2007年11月
• Knock down of hSNF5/Ini1 causes cell cycle arrest and apoptosis in a p53-dependent manner

  Hiroyuki Kato; Reiko Honma; Takaomi Sanda; Toshiyoshi Fujiwara; Emi Ito; Yuka Yanagisawa; Jun ichi Imai; Takashi Okamoto; Shinya Watanabe

  Biochemical and Biophysical Research Communications 361 3 580 - 585 2007年09月
• Transcription factors as therapeutic targets in lymphoid malignancies

  Takaomi Sanda

  International Reviews of Immunology 26 5-6 305 - 332 2007年09月
• NK-κB signaling and carcinogenesis

  Takashi Okamoto; Takaomi Sanda; Kaori Asamitsu

  Current Pharmaceutical Design 13 5 447 - 462 2007年02月
• Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid

  Takaomi Sanda; Shinsuke Iida; Satoshi Kayukawa; Ryuzo Ueda

  Haematologica 92 1 115 - 120 2007年01月
• Induction of cell death in adult T-cell leukemia cells by a novel IκB kinase inhibitor

  T. Sanda; K. Asamitsu; H. Ogura; S. Iida; A. Utsunomiya; R. Ueda; T. Okamoto

  Leukemia 20 4 590 - 598 2006年04月
• Severe hypercholesterolemia associated with decreased hepatic triglyceride lipase activity and pseudohyponatremia in patients after allogeneic stem cell transplantation

  Yoshihiro Inamoto; Tamio Teramoto; Koji Shirai; Hideko Tsukamoto; Takaomi Sanda; Koichi Miyamura; Ikuo Yamamori; Noriyuki Hirabayashi; Yoshihisa Kodera

  International Journal of Hematology 82 4 362 - 366 2005年11月
• Antimyeloma effects of a novel synthetic retinoid Am80 (Tamibarotene) through inhibition of angiogenesis

  T. Sanda; T. Kuwano; S. Nakao; S. Iida; T. Ishida; H. Komatsu; K. Shudo; M. Kuwano; M. Ono; R. Ueda

  Leukemia 19 6 901 - 909 2005年06月
• Growth inhibition of multiple myeloma cells by a novel IκB kinase inhibitor

  Takaomi Sanda; Shinsuke Iida; Hiroka Ogura; Kaori Asamitsu; Toshiki Murata; Kevin B. Bacon; Ryuzo Ueda; Takashi Okamoto

  Clinical Cancer Research 11 5 1974 - 1982 2005年03月
• Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferon-γ (MIG) gene expression in B-cell malignancy

  M. Uranishi; S. Iida; T. Sanda; T. Ishida; E. Tajima; M. Ito; H. Komatsu; H. Inagaki; R. Ueda

  Leukemia 19 8 1471 - 1478 2005年
• RNA helicase A interacts with nuclear factor κB p65 and functions as a transcriptional coactivator

  Toshifumi Tetsuka; Hiroaki Uranishi; Takaomi Sanda; Kaori Asamitsu; Jiang Ping Yang; Flossie Wong-Staal; Takashi Okamoto

  European Journal of Biochemistry 271 18 3741 - 3751 2004年09月
• Successful treatment of nasal T-cell lymphoma with a combination of local irradiation and high-dose chemotherapy

  Takaomi Sanda; Shinsuke Iida; Masato Ito; Kazuya Tsuboi; Kazuhisa Miura; Shinsuke Harada; Hirokazu Komatsu; Atsushi Wakita; Hiroshi Inagaki; Ryuzo Ueda

  International Journal of Hematology 75 2 195 - 200 2002年02月
• RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-κB and Sp1 actions

  Norio Takada; Takaomi Sanda; Hiroshi Okamoto; Jian Ping Yang; Kaori Asamitsu; Lilen Sarol; Genjiro Kimura; Hiroaki Uranishi; Toshifumi Tetsuka; Takashi Okamoto

  Journal of Virology 76 16 8019 - 8030 2002年
• Identification of a novel inhibitor of nuclear factor-κB, RelA- associated inhibitor

  Jian Ping Yang; Mayumi Hori; Takaomi Sanda; Takashi Okamoto

  Journal of Biological Chemistry 274 22 15662 - 15670 1999年05月

MISC

• Anti-Leukemic Activity of the TYK2 Selective Inhibitor Ndi-031301 in T-Cell Acute Lymphoblastic Leukemia

  Koshi Akahane; Zhaodong Li; Julia Etchin; Alla Berezovskaya; Evisa Gjini; Craig E. Masse; Wenyan Miao; Jennifer Rocnik; Rosana Kapeller; Jeremy R. Greenwood; Hong Tiv; Takaomi Sanda; David M. Weinstock; A. Thomas Look BLOOD 128 (22) 2016年12月
• Identification of Super-Enhancer-Associated Cancer Genes Provides Novel Therapeutic Targets in Adult T-Cell Leukemia/Lymphoma

  Regina Wan Ju Wong; Phuong Thi Ngoc Cao; Wei Zhong Leong; Alice Wei Yee Yam; Tinghu Zhang; Shinsuke Iida; Takashi Okamoto; Ryuzo Ueda; Nathanael S. Grey; Takashi Ishida; Takaomi Sanda BLOOD 128 (22) 2016年12月
• HSP90 Inhibition Has Potent Activity Against T-Cell Acute Lymphoblastic Leukemia (T-ALL) Through Degradation Of TYK2 Kinase

  Koshi Akahane; Takaomi Sanda; Marc R. Mansour; Julia Etchin; Ng Cherry; David M. Weinstock; Anthony Letai; Daniel J. DeAngelo; A. Thomas Look BLOOD 122 (21) 2013年11月
• Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase I inhibitor, irinotecan (CPT-11), for refractory multiple myeloma.

  Hiroki Yano; Satoshi Kayukawa; Shinsuke Iida; Chiharu Nakagawa; Takaomi Sanda; Shigeru Kusumoto; Takashi Ishida; Hirokazu Komatsu; Atsushi Suzuki; Ryuzo Ueda BLOOD 108 (11) 366B -366B 2006年11月
• Multiple myeloma oncogene 1 (MUM1)/interferon regulatory factor 4 (IRF4) upregulates monokine induced by interferongamma (MIG) gene expression in B-cell malignancy

  S Iida; M Uranishi; T Sanda; T Ishida; E Tajima; M Ito; H Komatsu; H Inagaki; R Ueda BLOOD 104 (11) 315A -315A 2004年11月

受賞

• 2013年 National Research Foundation, Singapore NRF Fellowship
  
• 2011年 National Cancer Institute/National Cancer Institute, US K99 Award
  
• 2009年 日本学術振興会 海外特別研究員
  

委員歴

• 2022年 - 現在   日本血液学会   評議員

その他のリンク

researchmap

https://researchmap.jp/tsanda