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西山 毅ニシヤマ タケシ

所属部署医学研究科公衆衛生学分野
職名准教授
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Last Updated :2020/06/03

研究者基本情報

学歴

  • 1991年04月 - 1997年03月, 名古屋市立大学, 医学部

学位

  • 医学博士, 名古屋市立大学大学院
  • Doctor of Public Health, 国立保健医療科学院

所属学協会

  • 日本衛生学会
  • 日本認知療法学会
  • 日本双生児研究学会
  • 日本行動計量学会
  • 日本計量生物学会
  • 日本計算統機計学会
  • 日本疫学会
  • 日本精神神経学会
  • 日本人類遺伝学会
  • American Society of Human Gentetics
  • 日本児童青年精神医学会

経歴

  •   2018年04月 - 現在, 名古屋市立大学大学院医学研究科, 公衆衛生学, 准教授
  •   2014年04月 - 2018年03月, 愛知医科大学医学部, 公衆衛生学, 准教授
  •   2014年08月 - 2015年07月, フレッドハッチンソンがん研究センター, Research fellow
  •   2013年04月 - 2014年03月, 愛知医科大学医学部, 公衆衛生学, 講師
  •   2009年10月 - 2013年03月, 名古屋市立大学病院, 臨床試験管理センター, 助教
  •   2007年04月 - 2012年03月, 国立保健医療科学院, 専門課程II(1年), 研究課程(4年), 生徒
  •   2004年04月 - 2007年03月, 刈谷記念病院, 心療内科, 勤務医
  •   2000年04月 - 2004年03月, 名古屋市立大学大学院医学研究科, 博士課程, 大学院生
  •   1999年04月 - 2000年03月, 名古屋市立大学病院, 精神科, 研究医
  •   1998年04月 - 1999年03月, 協立総合病院, 研修医
  •   1997年05月 - 1998年03月, 滋賀医科大学附属病院, 精神科, 研修医

研究活動情報

研究分野

  • ライフサイエンス, 精神神経科学
  • ライフサイエンス, 医療管理学、医療系社会学
  • ライフサイエンス, ゲノム生物学

研究キーワード

    生物統計学, 児童精神医学, 心理測定学, 遺伝疫学

論文

  • Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study., Hishida A, Nakatochi M, Akiyama M, Kamatani Y, Nishiyama T, Ito H, Oze I, Nishida Y, Hara M, Takashima N, Turin TC, Watanabe M, Suzuki S, Ibusuki R, Shimoshikiryo I, Nakamura Y, Mikami H, Ikezaki H, Furusyo N, Kuriki K, Endoh K, Koyama T, Matsui D, Uemura H, Arisawa K, Sasakabe T, Okada R, Kawai S, Naito M, Momozawa Y, Kubo M, Wakai K, Japan Multi-Institutional Collaborative Cohort, J-MICC, Study Group, American journal of nephrology, 47, (5) 304 - 316,   2018年05月, 査読有り
  • Association of genetic variants of PD1 with recurrent pregnancy loss., Hayashi Y, Nishiyama T, Nakatochi M, Suzuki S, Takahashi S, Sugiura-Ogasawara M, Reproductive medicine and biology, 17, (2) 195 - 202,   2018年04月, 査読有り
  • インターネットゲーム障害スケールの日本語版(IGDS-J)について, 鷲見 聡, 西山 毅, 市橋 佳世子, 原 大, 久留 友紀子, 中嶋 理香, 臨床精神医学 = Japanese journal of clinical psychiatry, 47, (1) 109 - 111,   2018年01月
  • Prediction model for pancreatic cancer risk in the general Japanese population., Nakatochi M, Lin Y, Ito H, Hara K, Kinoshita F, Kobayashi Y, Ishii H, Ozaka M, Sasaki T, Sasahira N, Morimoto M, Kobayashi S, Ueno M, Ohkawa S, Egawa N, Kuruma S, Mori M, Nakao H, Wang C, Nishiyama T, Kawaguchi T, Takahashi M, Matsuda F, Kikuchi S, Matsuo K, PloS one, 13, (9) ,   2018年, 査読有り
  • Changing trends in the prevalence of H. pylori infection in Japan (1908-2003): a systematic review and meta-regression analysis of 170,752 individuals, Chaochen Wang, Takeshi Nishiyama, Shogo Kikuchi, Manami Inoue, Norie Sawada, Shoichiro Tsugane, Yingsong Lin, SCIENTIFIC REPORTS, 7, (1) ,   2017年11月, 査読有り, Changing trends in the prevalence of H. pylori infection in the general population over time are thought to be the main driving force behind the declining gastric cancer mortality in Japan. However, whether the prevalence of H. pylori infection itself shows a birth-cohort pattern needs to be corroborated. We performed a systematic review of studies that reported the prevalence of H. pylori infection among Japanese individuals. Meta-regression was conducted in the framework of a generalized additive mixed model (GAMM) to account for heterogeneity in the prevalence of H. pylori infection as a function of birth year. The prevalence of H. pylori infection confirmed a clear birth cohort pattern: the predicted prevalence (%, 95% CI) was 60.9 (56.3-65.4), 65.9 (63.9-67.9), 67.4 (66.0-68.7), 64.1 (63.1-65.1), 59.1 (58.2-60.0), 49.1 (49.0-49.2), 34.9 (34.0-35.8), 24.6 (23.5-25.8), 15.6 (14.0-17.3), and 6.6 (4.8-8.9) among those who were born in the year 1910, 1920, 1930, 1940, 1950, 1960, 1970, 1980, 1990, and 2000, respectively. The present study demonstrated a clear birth-cohort pattern of H. pylori infection in the Japanese population. The decreased prevalence of H. pylori infection in successive generations should be weighed in future gastric cancer control programs.
  • Perceived Stress and Colorectal Cancer Incidence: The Japan Collaborative Cohort Study, Norimasa Kikuchi, Takeshi Nishiyama, Takayuki Sawada, Chaochen Wang, Yingsong Lin, Yoshiyuki Watanabe, Akiko Tamakoshi, Shogo Kikuchi, SCIENTIFIC REPORTS, 7,   2017年01月, 査読有り, Colorectal cancer is the third most common cancer worldwide, and many risk factors for colorectal cancer have been established. However, it remains uncertain whether psychological stress contributes to the onset of colorectal cancer. Therefore, we conducted a large-scale prospective cohort study to confirm the association between perceived stress and colorectal cancer incidence. We identified 680 cases of colon cancer and 330 cases of rectal cancer during a maximum of 21-year follow-up of 61,563 Japanese men and women. Cox regression analysis adjusted for potential confounders revealed a significant association of perceived stress with rectal cancer incidence but not with colon cancer incidence. This finding is partly consistent with that from only one previous study that addressed an association between perceived stress and the risk of colorectal cancer. However, studies on this topic are sparse and warrant further exploration.
  • The influence of personality and perceived stress on the development of breast cancer: 20-year follow-up of 29,098 Japanese women, Takayuki Sawada, Takeshi Nishiyama, Norimasa Kikuchi, Chaochen Wang, Yingsong Lin, Mitsuru Mori, Kozo Tanno, Akiko Tamakoshi, Shogo Kikuchi, SCIENTIFIC REPORTS, 6,   2016年09月, 査読有り, Breast cancer is the most common cancer in women. However, it remains unproven whether psychological factors have an influence on breast cancer incidence. In our earlier study, subjects possessing two personality traits, decisiveness and "ikigai" (a Japanese word meaning something that makes one's life worth living), showed a significantly lower risk of developing breast cancer, although no psychological factors have been convincingly demonstrated to have an influence on breast cancer development in other studies. Therefore, we conducted this follow-up analysis to confirm the association between breast cancer incidence and psychological traits, using the final dataset of a large-scale prospective cohort study in Japan. We identified 209 cases of incident breast cancer out of a maximum 21-year follow-up of 29,098 Japanese women. Cox proportional hazard regression analysis, adjusted for the same potential confounders used in our previous study, did not reveal any significant relationships between breast cancer incidence and four psychological traits: having "ikigai", decisiveness, ease of anger arousal, and perceived stress. Our finding is consistent with previous studies, and suggests that the psychological traits are unlikely to be an important risk factor for breast cancer.
  • Microaneurysms cause refractory macular edema in branch retinal vein occlusion, Taneto Tomiyasu, Yoshio Hirano, Munenori Yoshida, Norihiro Suzuki, Takeshi Nishiyama, Akiyoshi Uemura, Tsutomu Yasukawa, Yuichiro Ogura, SCIENTIFIC REPORTS, 6,   2016年07月, 査読有り, Intravitreal anti-vascular endothelial growth factor (VEGF) agents can treat macular edema (ME) in branch retinal vein occlusion (BRVO). However, refractory ME, the mechanism of which is not well elucidated, occurs frequently. Sixty-six eyes with ME secondary to BRVO were enrolled in this retrospective observational case-control study. Twenty eyes received a sub-Tenon's capsule injection of triamcinolone acetonide (STTA), 22 eyes an intravitreal anti-VEGF injection (ranibizumab), 16 eyes were switched from STTA to ranibizumab, 4 eyes underwent vitrectomy, and 4 eyes were untreated. Multiple regression analysis and multivariate logistic regression analysis were conducted, respectively, to identify independent predictors of visual acuity (VA) prognosis and risk factors for refractory ME longer than 1 year. The mechanism of refractory ME and therapeutic approaches for identified risk factors also were investigated. Thirty-four (52%) eyes had refractory ME for over 1 year. Microaneurysms were identified as risk factors for refractory ME, leading to poor final VA. Ranibizumab suppressed microaneurysm formation and refractory ME, with early administration more effective. For already formed microaneurysms, laser photocoagulation reduced additional treatments. Microaneurysms may cause refractory ME in BRVO. Alternative therapy to suppress microaneurysms should be considered to prevent refractory ME in patients with BRVO.
  • Associations between polymorphisms in folate-metabolizing genes and pancreatic cancer risk in Japanese subjects, Haruhisa Nakao, Kenji Wakai, Norimitsu Ishii, Yuji Kobayashi, Kiyoaki Ito, Masashi Yoneda, Mitsuru Mori, Masanori Nojima, Yasutoshi Kimura, Takao Endo, Masato Matsuyama, Hiroshi Ishii, Makoto Ueno, Sawako Kuruma, Naoto Egawa, Keitaro Matsuo, Satoyo Hosono, Shinichi Ohkawa, Kozue Nakamura, Akiko Tamakoshi, Mami Takahashi, Kazuaki Shimada, Takeshi Nishiyama, Shogo Kikuchi, Yingsong Lin, BMC GASTROENTEROLOGY, 16, (1) ,   2016年07月, 査読有り, Background: Evidence supporting the associations between folate metabolizing gene polymorphisms and pancreatic cancer has been inconclusive. We examined their associations in a case-control study of Japanese subjects. Methods: Our case-control study involved 360 newly diagnosed pancreatic cancer cases and 400 frequency-matched, non-cancer control subjects. We genotyped four folate metabolizing gene polymorphisms, including two polymorphisms (rs1801133 and rs1801131) in the methylenetetrahydrofolate (MTHFR) gene, one polymorphism (rs1801394) in the 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) gene and one polymorphism (rs1805087) in the 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR) gene. Genotyping was performed using Fluidigm SNPtype assays. Unconditional logistic regression methods were used to estimate odds ratios (ORs) and 95 % confidence intervals (CIs) for the associations between folate metabolizing gene variants and pancreatic cancer risk. Results: Overall we did not observe a significant association between these four genotypes and pancreatic cancer risk. For rs1801133, compared with individuals with the CC genotype of MTHFR C677T, the OR for those with the CT genotype and TT genotype was 0.87 (0.62-1.22) and 0.99 (0.65-1.51), respectively. For rs1801131, individuals with the CC genotype had approximately 1.2-fold increased risk compared with those with the AA genotype, but the association was not statistically significant. In analyses stratified by smoking and drinking status, no significant associations were noted for C677T genotypes. No significant interactions were observed with smoking and drinking with respect to pancreatic cancer risk. Conclusions: Our data did not support the hypothesis that MTHFR polymorphisms or other polymorphisms in the folate metabolizing pathway are associated with pancreatic cancer risk.
  • Effectiveness of a psycho-oncology training program for oncology nurses: a randomized controlled trial, Yosuke Kubota, Toru Okuyama, Megumi Uchida, Shino Umezawa, Tomohiro Nakaguchi, Koji Sugano, Yoshinori Ito, Fujika Katsuki, Yumi Nakano, Takeshi Nishiyama, Yoshiko Katayama, Tatsuo Akechi, PSYCHO-ONCOLOGY, 25, (6) 712 - 718,   2016年06月, 査読有り, ObjectiveOncology nurses are expected to play an important role in psychosocial care for cancer patients. The aim of this study was to examine whether a novel training program aimed at enhancing oncology nurses' ability to assess and manage common psychological problems in cancer patients would improve participants' self-reported confidence, knowledge, and attitudes regarding care of patients with common psychological problems (trial register: UMIN000008559). MethodsOncology nurses were assigned randomly to either the intervention group (N=50) or the waiting list control group (N=46). The intervention group received a 16-h program, the content of which focused on four psychological issues: normal reactions, clinically significant distress, suicidal thoughts, and delirium. Each session included a role-play exercise, group work, and didactic lecture regarding assessment and management of each problem. Primary outcomes were changes in self-reported confidence, knowledge, and attitudes toward the common psychological problems between pre-intervention and 3months post-intervention. Secondary outcomes were job-related stress and burnout. Intervention acceptability to participants was also assessed. ResultsIn the intervention group, confidence and knowledge but not attitudes were significantly improved relative to the control group. No significant intervention effects were found for job- related stress and burnout. A high percentage (98%) of participants considered the program useful in clinical practice. ConclusionsThis psycho-oncology training program improved oncology nurses' confidence and knowledge regarding care for patients with psychological problems. Copyright (c) 2015 John Wiley & Sons, Ltd.
  • The relationship between the season of birth and early-onset food allergies in children., Tanaka K, Matsui T, Sato A, Sasaki K, Nakata J, Nakagawa T, Sugiura S, Kando N, Nishiyama T, Kojima S, Ito K, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 26, (7) 607 - 613,   2015年11月, 査読有り
  • Genome-wide association study-identified SNPs (rs3790844, rs3790843) in the NR5A2 gene and risk of pancreatic cancer in Japanese., Ueno M, Ohkawa S, Morimoto M, Ishii H, Matsuyama M, Kuruma S, Egawa N, Nakao H, Mori M, Matsuo K, Hosono S, Nojima M, Wakai K, Nakamura K, Tamakoshi A, Takahashi M, Shimada K, Nishiyama T, Kikuchi S, Lin Y, Scientific reports, 5,   2015年11月, 査読有り
  • Association between shift work and the risk of death from biliary tract cancer in Japanese men., Lin Y, Nishiyama T, Kurosawa M, Tamakoshi A, Kubo T, Fujino Y, Kikuchi S, JACC Study Group, BMC cancer, 15,   2015年10月, 査読有り
  • Quantitative analysis of attachment of the labrum to the glenoid fossa: a cadaveric study., Yoshida M, Goto H, Nozaki M, Nishimori Y, Takenaga T, Murase A, Nagaya Y, Iguchi H, Kobayashi M, Sugimoto K, Nishiyama T, Otsuka T, Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 20, (5) 823 - 829,   2015年09月, 査読有り
  • Genetic epidemiology of tooth agenesis in Japan: a population- and family-based study., Machida J, Nishiyama T, Kishino H, Yamaguchi S, Kimura M, Shibata A, Tatematsu T, Kamamoto M, Yamamoto K, Makino S, Miyachi H, Shimozato K, Tokita Y, Clinical genetics, 88, (2) 167 - 171,   2015年08月, 査読有り
  • Diagnostic Accuracy of Real-Time Tissue Elastography for the Staging of Liver Fibrosis: A Meta-Analysis, Kunio Kobayashi, Haruhisa Nakao, Takeshi Nishiyama, Yingsong Lin, Shogo Kikuchi, Yuji Kobayashi, Takaya Yamamoto, Norimitsu Ishii, Tomohiko Ohashi, Ken Satoh, Yukiomi Nakade, Kiyoaki Ito, Masashi Yoneda, EUROPEAN RADIOLOGY, 25, (1) 230 - 238,   2015年01月, 査読有り, Objective To evaluate the overall accuracy of real-time tissue elastography (RTE) for the staging of liver fibrosis. Methods We systematically reviewed 15 studies (1,626 subjects) in which sensitivity and specificity of RTE for liver fibrosis are available. For each cut-off stage of fibrosis, i.e., F >= 1, F >= 2, F >= 3, and F >= 4, summary sensitivity and specificity were estimated using a bivariate random-effects model. Publication bias was assessed using funnel plots and Egger's test. Results Summary sensitivity and specificity were 0.79 and 0.76 for F >= 2, 0.82 and 0.81 for F >= 3, and 0.74 and 0.84 for F >= 4, respectively. Meta-regressions revealed scoring methods of RTE and liver diseases in the samples might not influence sensitivity and specificity of RTE. However, the estimated accuracy of RTE might be overestimated due to publication bias (p=0.004 for F >= 2, p< 0.001 for F >= 3, and p=0.002 for F >= 4). Conclusions RTE is not highly accurate for any cut-off stage of fibrosis. Compared with findings of meta-analyses on Transient Elastography and Acoustic Radiation Force Impulse imaging, the overall accuracy of RTE seems to be nearly identical for the evaluation of significant liver fibrosis, but less accurate for the evaluation of cirrhosis.
  • Case-control study of diabetes-related genetic variants and pancreatic cancer risk in Japan, Sawako Kuruma, Naoto Egawa, Masanao Kurata, Goro Honda, Terumi Kamisawa, Junko Ueda, Hiroshi Ishii, Makoto Ueno, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo, Satoyo Hosono, Shinichi Ohkawa, Kenji Wakai, Kozue Nakamura, Akiko Tamakoshi, Masanori Nojima, Mami Takahashi, Kazuaki Shimada, Takeshi Nishiyama, Shogo Kikuchi, Yingsong Lin, WORLD JOURNAL OF GASTROENTEROLOGY, 20, (46) 17456 - 17462,   2014年12月, 査読有り, AIM: To examine whether diabetes-related genetic variants are associated with pancreatic cancer risk. METHODS: We genotyped 7 single-nucleotide polymorphisms (SNPs) in PPARG2 (rs1801282), ADIPOQ (rs1501299), ADRB3 ( rs4994), KCNQ 1 (rs2237895), KCNJ11 (rs5219), TCF7L2 (rs7903146), and CDKAL1 (rs2206734), and examined their associations with pancreatic cancer risk in a multi-institute case-control study including 360 cases and 400 controls in Japan. A self-administered questionnaire was used to collect detailed information on lifestyle factors. Genotyping was performed using Fluidigm SNPtype assays. Unconditional logistic regression methods were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the association between these diabetes-associated variants and pancreatic cancer risk. RESULTS: With the exception of rs1501299 in the ADIPOQ gene (p = 0.09), no apparent differences in genotype frequencies were observed between cases and controls. Rs1501299 in the ADPIOQ gene was positively associated with pancreatic cancer risk; compared with individuals with the AA genotype, the age- and sex-adjusted OR was 1.79 (95% CI: 0.98-3.25) among those with the AC genotype and 1.86 (95% CI: 1.03-3.38) among those with the CC genotype. The ORs remained similar after additional adjustment for body mass index and cigarette smoking. In contrast, rs2237895 in the KCNQ1 gene was inversely related to pancreatic cancer risk, with a multivariable-adjusted OR of 0.62 (0.37-1.04) among individuals with the CC genotype compared with the AA genotype. No significant associations were noted for other 5 SNPs. CONCLUSION: Our case-control study indicates that rs1501299 in the ADIPOQ gene may be associated with pancreatic cancer risk. These findings should be replicated in additional studies. (C) 2014 Baishideng Publishing Group Inc. All rights reserved.
  • Ultrasound imaging of the humeral capitellum: a cadaveric study, Tetsuya Takenaga, Hideyuki Goto, Masahiro Nozaki, Masahito Yoshida, Takeshi Nishiyama, Takanobu Otsuka, JOURNAL OF ORTHOPAEDIC SCIENCE, 19, (6) 907 - 912,   2014年11月, 査読有り, Background Ultrasound is suitable for routine examinations of capitellar osteochondritis dissecans because it can visualize both the subchondral bone and the overlying articular cartilage non-invasively. The radial head interferes with the sonographically visible area of the articular surface of the humeral capitellum, although the precise extent of this is currently unknown. This study aimed to investigate the visible area of the humeral capitellum using both anterior and posterior ultrasonographic scans. Methods Twelve elbows were used from cadavers with a mean age of 85.6 years. After marking a 45 degrees angle in the anterior capitellum in a caudal direction using a drill, anterior and posterior, long-axis ultrasonographic scans were performed with the cadaveric elbows bent. The elbow-flexion angle at which the 45 degrees point was obscured by the radial head was measured and these ultrasonic measurements were then verified by macroscopic observation. Results The elbow-flexion angle at which the 45 degrees point was obscured by the radial head was 24 degrees in anterior scans and 102 degrees in posterior scans. These ultrasonic measurements corresponded to the macroscopic measurements. The results showed that anterior, long-axis ultrasound scans could visualize the capitellum from 45 degrees through the rest of the anterior area at 24 degrees flexion of the elbow: the radial head obscured the area of the capitellum that is 21 degrees anterior to the elbow flexion angle. Similarly, posterior long-axis scans could visualize the capitellum from 45 degrees through the rest of the posterior area at 102 degrees flexion of the elbow: the radial head obscured the area of the capitellum that is 57 degrees posterior to the elbow flexion angle. The radial head obscured a 78 degrees (21 degrees +/- 57 degrees) arc of the capitellum in ultrasonography. Conclusions This study thus clarified the area of the humeral capitellum visible in both anterior and posterior ultrasound scans in the sagittal plane.
  • On the Misapplication of the BAPQ in a Study of Autism, Takeshi Nishiyama, Stephen M. Kanne, JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 44, (8) 2079 - 2080,   2014年08月, 査読有り
  • Broad Autism Phenotype Questionnaire日本語版(BAPQ-J)の妥当性と信頼性の検討, 酒井 佐枝子, 和田 奈緒子, 奥野 裕子, 辰巳愛香, 山本知加, 吉崎亜里香, 西 山毅, 下野九理子, 毛 利育 子, 谷 池雅 了, 臨床精神医学, 43, (8) 1181 - 1190,   2014年08月
  • Comprehensive Comparison of Self-administered Questionnaires for Measuring Quantitative Autistic Traits in Adults, Takeshi Nishiyama, Masako Suzuki, Katsunori Adachi, Satoshi Sumi, Kensuke Okada, Hirohisa Kishino, Saeko Sakai, Yoko Kamio, Masayo Kojima, Sadao Suzuki, Stephen M. Kanne, JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 44, (5) 993 - 1007,   2014年05月, 査読有り, We comprehensively compared all available questionnaires for measuring quantitative autistic traits (QATs) in terms of reliability and construct validity in 3,147 non-clinical and 60 clinical subjects with normal intelligence. We examined four full-length forms, the Subthreshold Autism Trait Questionnaire (SATQ), the Broader Autism Phenotype Questionnaire, the Social Responsiveness Scale2-Adult Self report (SRS2-AS), and the Autism-Spectrum Quotient (AQ). The SRS2-AS and the AQ each had several short forms that we also examined, bringing the total to 11 forms. Though all QAT questionnaires showed acceptable levels of test-re-test reliability, the AQ and SRS2-AS, including their short forms, exhibited poor internal consistency and discriminant validity, respectively. The SATQ excelled in terms of classical test theory and due to its short length.
  • Criterion validity of the Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale for the diagnosis of sleep disorders, Takeshi Nishiyama, Tomoki Mizuno, Masayo Kojima, Sadao Suzuki, Tsuyoshi Kitajima, Kayoko Bhardwaj Ando, Shinichi Kuriyama, Meiho Nakayama, SLEEP MEDICINE, 15, (4) 422 - 429,   2014年04月, 査読有り, Objectives: (1) To examine criterion validity of the Pittsburgh Sleep Quality Index (PSQI) and Epworth Sleepiness Scale (ESS) using obstructive sleep apnea (OSA), periodic limb movement disorder (PLMD), rapid eye movement sleep behavior disorder (RBD), and narcolepsy as criterion standard. (2) To summarize the evidence for criterion validity of the ESS for the diagnosis of OSA by a meta-analysis that combines the current and previous studies. (3) To investigate the determinants of the PSQI and ESS scores. Methods: The PSQI and ESS as well as the Hospital Anxiety and Depression Scale (HADS), which measures anxiety and depression levels, were administered to 367 patients consecutively referred to a sleep clinic. They underwent overnight polysomnography (PSG) and the multiple sleep latency test if narcolepsy was suspected. Results: The area under the receiver operating characteristic curves for the ESS and PSQI (and its sub-scale) were <0.9, meaning that these questionnaires were not highly accurate for predicting the four sleep disorders. The meta-analysis found that the ESS had no value in identifying OSA. The variable that most strongly influenced PSQI or ESS scores was the HADS score. Conclusion: The PSQI and ESS should no longer be used as a screening or diagnostic instrument for the four PSG-defined sleep disorders, especially in a low-risk population. (C) 2014 Elsevier B. V. All rights reserved.
  • Diagnostic Accuracy of the E-Plate Serum Antibody Test Kit in Detecting Helicobacter pylori Infection Among Japanese Children, Junko Ueda, Masumi Okuda, Takeshi Nishiyama, Yingsong Lin, Yoshihiro Fukuda, Shogo Kikuchi, JOURNAL OF EPIDEMIOLOGY, 24, (1) 47 - 51,   2014年01月, 査読有り, Background: A number of noninvasive diagnostic tests are available to detect Helicobacter pylori infection. Data on serologic testing of children are lacking, however, and thus it remains unclear whether the serology cutoff points used for adults are appropriate for children. Methods: Serum and stool samples were obtained from 73 children who visited 5 hospitals in Japan between March 1993 and December 2009. Analysis of stool samples was carried out using an H pylori stool antigen enzyme-linked immunosorbent assay (HpSA ELISA), and serum antibodies to H pylori were examined using an antibody determination kit (E-Plate Eiken H pylori antibody). The validity of the serologic test was evaluated based on its sensitivity, specificity, and receiver operating characteristics curve. Results: Of the 73 children included in this study, 34 were HpSA-positive and 39 were negative. Among the 34 HpSA-positive patients, 32 were IgG-positive and 2 were IgG-negative. Of the 39 patients who were HpSA-negative, 38 were IgG-negative and 1 was IgG-positive. The sensitivity, specificity, and positive likelihood ratio for IgG antibody testing were 91.2%, 97.4%, and 35.6, respectively, based on the recommended adult cutoff point of 10 U/ml. Among children, use of cutoff points in the range of 7 to 9 U/ml yielded optimal values for sensitivity and specificity, as well as a positive likelihood ratio. Conclusions: The performance of the E-plate anti-H pylori IgG antibody test was comparable to that of the stool antigen test and is therefore suitable for epidemiologic studies of H pylori infection in large samples.
  • Lack of Associations between Genetic Polymorphisms in GSTM1, GSTT1 and GSTP1 and Pancreatic Cancer Risk: A Multi-Institutional Case-Control Study in Japan, Ikuhiro Yamada, Masato Matsuyama, Masato Ozaka, Dai Inoue, Yusuke Muramatsu, Hiroshi Ishii, Ueda Junko, Makoto Ueno, Naoto Egawa, Haruhisa Nakao, Mitsuru Mori, Keitaro Matsuo, Takeshi Nishiyama, Shinichi Ohkawa, Satoyo Hosono, Kenji Wakai, Kozue Nakamura, Akiko Tamakoshi, Sawako Kuruma, Masanori Nojima, Mami Takahashi, Kazuaki Shimada, Kiyoko Yagyu, Shogo Kikuchi, Yingsong Lin, ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 15, (1) 391 - 395,   2014年, 査読有り, Background: We aimed to evaluate the role of genetic polymorphisms in tobacco carcinogen-metabolizing genes and their interactions with smoking in a hospital-based case-control study of Japanese subjects. Materials and Methods: We examine the associations of pancreatic cancer risk with genetic polymorphisms in GSTM1, GSTT1 and GSTP1, phase II enzymes that catalyze the conjugation of toxic and carcinogenic electrophilic molecules. The study population consisted of 360 patients and 400 control subjects, who were recruited from several medical facilities in Japan. Unconditional logistic regression methods were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and pancreatic cancer risk. Results: Among the control subjects, the prevalence of the GSTM1-null genotype and the GSTT1-null genotype was approximately 56% and 48%, respectively. Cases and controls were comparable in terms of GSTM1 and GSTT1 genotype distributions. Neither of the deleted polymorphisms in GSTM1 and GSTT1 was associated with the risk of pancreatic cancer, with an age-and sex-adjusted OR of 0.99 (95% CI: 0.74-1.32) for the GSTM1-null genotype, and 0.98 (95% CI: 0.73-1.31) for the GSTT1-null genotype. The OR was 0.97 (95% CI: 0.64-1.47) for individuals with the GSTM1 and GSTT1-null genotypes compared with those with the GSTM1 and GSTT1-present genotypes. No synergistic effects of smoking or GST genotypes were observed. Conclusions: Our results indicate no overall association between the GSTM1 and GSTT1 deletion polymorphisms and pancreatic cancer risk in the Japanese subjects in our study.
  • A failure to confirm the effectiveness of a brief group psychoeducational program for mothers of children with high-functioning pervasive developmental disorders: a randomized controlled pilot trial., Suzuki M, Yamada A, Watanabe N, Akechi T, Katsuki F, Nishiyama T, Imaeda M, Miyachi T, Otaki K, Mitsuda Y, Ota A, Furukawa TA, Neuropsychiatric disease and treatment, 10, 1141 - 1153,   2014年, 査読有り
  • Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss, Yuko Hayashi, Hidefumi Sasaki, Sadao Suzuki, Takeshi Nishiyama, Tamao Kitaori, Eita Mizutani, Nobuhiro Suzumori, Mayumi Sugiura-Ogasawara, FERTILITY AND STERILITY, 100, (4) 1018 - 1024,   2013年10月, 査読有り, Objective: To investigate whether polymorphisms at the promoter or 5'-untranslated region of annexin A5 gene (ANXA5) influence miscarriage. Design: Case-control study and nested case-control study. Setting: Hospitals. Patient(s): A total of 264 patients with two to nine recurrent pregnancy losses (RPLs) and 195 fertile control subjects. Intervention(s): None. Main Outcome Measure(s): The frequency of six single-nucleotide polymorphisms (SNPs) of the ANXA5 gene in RPL patients versus control subjects, and subsequent live birth rate with and without risk alleles in RPL patients. Result(s): The minor allele was significantly more frequent in RPL patients than in control subjects for SNP5 (rs1050606). The live birth rates of patients with and without risk alleles of SNP5 were 84.0% and 84.3%, respectively, after excluding cases with abnormal embryonic karyotype, with no significant difference. Conclusion(s): The variations with the ANXA5 gene upstream region, especially SNP5, were confirmed to be risk factors of RPL. However, presence/absence of the ANXA5 risk allele did not have any predictive effect for subsequent pregnancy outcome. This was the first study indicating the influence of ANXA5 SNP5 for pregnancy outcome. (Fertil Steril (R) 2013;100:1018-24. (C) 2013 by American Society for Reproductive Medicine.)
  • Allogeneic hematopoietic stem cell transplantation for adult T-cell leukemia-lymphoma with special emphasis on preconditioning regimen: a nationwide retrospective study, Takashi Ishida, Masakatsu Hishizawa, Koji Kato, Ryuji Tanosaki, Takahiro Fukuda, Shuichi Taniguchi, Tetsuya Eto, Yoshifusa Takatsuka, Yasushi Miyazaki, Yukiyoshi Moriuchi, Michihiro Hidaka, Koichi Akashi, Naokuni Uike, Hisashi Sakamaki, Yasuo Morishima, Koji Kato, Ritsuro Suzuki, Takeshi Nishiyama, Atae Utsunomiya, BLOOD, 120, (8) 1734 - 1741,   2012年08月, 査読有り, Adult T-cell leukemia-lymphoma (ATL) is an intractable mature T-cell neoplasm. We performed a nationwide retrospective study of allogeneic hematopoietic stem cell transplantation (HSCT) for ATL in Japan, with special emphasis on the effects of the preconditioning regimen. This is the largest study of ATL patients receiving HSCT. Median overall survival (OS) and 3-year OS of bone marrow or peripheral blood transplantation recipients (n = 586) was 9.9 months (95% confidence interval, 7.4-13.2 months) and 36% (32%-41%), respectively. These values for recipients of myeloablative conditioning (MAC; n = 280) and reduced intensity conditioning (RIC; n = 306) were 9.5 months (6.7-18.0 months) and 39% (33%-45%) and 10.0 months (7.2-14.0 months) and 34% (29%-40%), respectively. Multivariate analysis demonstrated 5 significant variables contributing to poorer OS, namely, older age, male sex, not in complete remission, poor performance status, and transplantation from unrelated donors. Although no significant difference in OS between MAC and RIC was observed, there was a trend indicating that RIC contributed to better OS in older patients. Regarding mortality, RIC was significantly associated with ATL-related mortality compared with MAC. In conclusion, allogeneic HSCT not only with MAC but also with RIC is an effective treatment resulting in long-term survival in selected patients with ATL. (Blood. 2012;120(8):1734-1741)
  • Organizing pneumonia after stereotactic ablative radiotherapy of the lung, Taro Murai, Yuta Shibamoto, Takeshi Nishiyama, Fumiya Baba, Akifumi Miyakawa, Shiho Ayakawa, Hiroyuki Ogino, Shinya Otsuka, Hiromitsu Iwata, RADIATION ONCOLOGY, 7,   2012年08月, 査読有り, Background: Organizing pneumonia (OP), so called bronchiolitis obliterans organizing pneumonia after postoperative irradiation for breast cancer has been often reported. There is little information about OP after other radiation modalities. This cohort study investigated the clinical features and risk factors of OP after stereotactic ablative radiotherapy of the lung (SABR). Methods: Patients undergoing SABR between 2004 and 2010 in two institutions were investigated. Blood test and chest computed tomography were performed at intervals of 1 to 3 months after SABR. The criteria for diagnosing OP were: 1) mixture of patchy and ground-glass opacity, 2) general and/or respiratory symptoms lasting for at least 2 weeks, 3) radiographic lesion in the lung volume receiving < 0.5 Gy, and 4) no evidence of a specific cause. Results: Among 189 patients (164 with stage I lung cancer and 25 with single lung metastasis) analyzed, nine developed OP. The incidence at 2 years was 5.2% (95% confidence interval; 2.6-9.3%). Dyspnea were observed in all patients. Four had fever. These symptoms and pulmonary infiltration rapidly improved after corticosteroid therapy. Eight patients had presented with symptomatic radiation pneumonitis (RP) around the tumor 2 to 7 months before OP. The prior RP history was strongly associated with OP (hazard ratio 61.7; p = 0.0028) in multivariate analysis. Conclusions: This is the first report on OP after SABR. The incidence appeared to be relatively high. The symptoms were sometimes severe, but corticosteroid therapy was effective. When patients after SABR present with unusual pneumonia, OP should be considered as a differential diagnosis, especially in patients with prior symptomatic RP.
  • Satisfaction and attitudes toward therapy in patients with rheumatoid arthritis, Nobuyuki Takahashi, Kaneshige Sasaki, Takeshi Nishiyama, Taio Naniwa, MODERN RHEUMATOLOGY, 22, (3) 376 - 381,   2012年06月, 査読有り, We examined associations between patient satisfaction and data obtained in routine clinical practice, and associations with therapeutic attitude in patients with rheumatoid arthritis (RA). A total of 220 patients with RA were enrolled in this cross-sectional evaluation. Demographic data, current disease state of RA, history of adverse events and self-reported questionnaire of patient satisfaction, attitudes toward therapy and reasons for being unwilling to change therapy were collected and analyzed. Multiple linear regression was used to identify characteristics. Age, Stanford Health Assessment Questionnaire (HAQ) score, and a visual analogue scale score of general health were the dominant correlates of satisfaction. Among the participants, 70% reported that they would not want to change therapy. The main reasons given were satisfaction with the current disease state (58%) and concern about the risk of side effects if therapy were to be changed (34%). Patients who were unwilling to change therapy due to concerns about side effects of new drugs did not have a significantly higher frequency of a past history of side effects, but showed significantly higher disease activity and a lower level of satisfaction with therapy. To summarize, patient satisfaction was associated with the HAQ. Patients who worried about the risk of side effects showed poor physical function and higher disease activity.
  • Detailed Analysis of Japanese Population Substructure with a Focus on the Southwest Islands of Japan, Takeshi Nishiyama, Hirohisa Kishino, Sadao Suzuki, Ryosuke Ando, Hideshi Niimura, Hirokazu Uemura, Mikako Horita, Keizo Ohnaka, Nagato Kuriyama, Haruo Mikami, Naoyuki Takashima, Keitaro Mastuo, Yin Guang, Kenji Wakai, Nobuyuki Hamajima, Hideo Tanaka, PLOS ONE, 7, (4) ,   2012年04月, 査読有り, Uncovering population structure is important for properly conducting association studies and for examining the demographic history of a population. Here, we examined the Japanese population substructure using data from the Japan Multi-Institutional Collaborative Cohort (J-MICC), which covers all but the northern region of Japan. Using 222 autosomal loci from 4502 subjects, we investigated population substructure by estimating FST among populations, testing population differentiation, and performing principal component analysis (PCA) and correspondence analysis (CA). All analyses revealed a low but significant differentiation between the Amami Islanders and the mainland Japanese population. Furthermore, we examined the genetic differentiation between the mainland population, Amami Islanders and Okinawa Islanders using six loci included in both the Pan-Asian SNP (PASNP) consortium data and the J-MICC data. This analysis revealed that the Amami and Okinawa Islanders were differentiated from the mainland population. In conclusion, we revealed a low but significant level of genetic differentiation between the mainland population and populations in or to the south of the Amami Islands, although genetic variation between both populations might be clinal. Therefore, the possibility of population stratification must be considered when enrolling the islander population of this area, such as in the J-MICC study.
  • Genetic and environmental predictors, endogenous hormones and growth factors, and risk of estrogen receptor-positive breast cancer in Japanese women, Nobuyasu Yoshimoto, Takeshi Nishiyama, Tatsuya Toyama, Satoru Takahashi, Norio Shiraki, Hiroshi Sugiura, Yumi Endo, Mai Iwasa, Yoshitaka Fujii, Hiroko Yamashita, CANCER SCIENCE, 102, (11) 2065 - 2072,   2011年11月, 査読有り, The incidence of breast cancer in Japanese women has doubled in all age groups over the past two decades. We have recently shown that this marked increase is mostly due to an increase in the estrogen receptor (ER)-positive subtype. It is necessary to establish risk factors capable of predicting the risk of ER-positive breast cancer that will enable the efficient selection of candidates for preventive therapy. We analyzed genetic factors, including 14 single nucleotide polymorphisms (SNPs), environmental risk factors (body mass index, age at menarche, pregnancy, age at first birth, breastfeeding, family history of breast cancer, age at menopause, use of hormone replacement therapy, alcohol intake, and smoking), serum hormones and growth factors (estradiol, testosterone, prolactin, insulin-like growth factor 1 [IGF1] and IGF binding protein 3 [IGFBP3]), and mammographic density in 913 women with breast cancer and 278 disease-free controls. To identify important risk factors, risk prediction models for ER-positive breast cancer in both pre- and postmenopausal women were created by logistic regression analysis. In premenopausal women, one SNP (CYP19A1-rs10046), age, pregnancy, breastfeeding, alcohol intake, serum levels of prolactin, testosterone, and IGFBP3 were considered to be risk predictors. In postmenopausal women, one SNP (TP53-rs1042522), age, body mass index, age at menopause, serum levels of testosterone, and IGF1 were identified as risk predictors. Risk factors may differ between women of different menopausal status, and inclusion of common genetic variants and serum hormone measurements as well as environmental factors might improve risk assessment models. Further validation studies will clarify appropriate risk groups for preventive therapy. (Cancer Sci 2011; 102: 2065-2072)
  • A scan statistic to extract causal gene clusters from case-control genome-wide rare CNV data, Takeshi Nishiyama, Kunihiko Takahashi, Toshiro Tango, Dalila Pinto, Stephen W. Scherer, Satoshi Takami, Hirohisa Kishino, BMC BIOINFORMATICS, 12,   2011年05月, 査読有り, Background: Several statistical tests have been developed for analyzing genome-wide association data by incorporating gene pathway information in terms of gene sets. Using these methods, hundreds of gene sets are typically tested, and the tested gene sets often overlap. This overlapping greatly increases the probability of generating false positives, and the results obtained are difficult to interpret, particularly when many gene sets show statistical significance. Results: We propose a flexible statistical framework to circumvent these problems. Inspired by spatial scan statistics for detecting clustering of disease occurrence in the field of epidemiology, we developed a scan statistic to extract disease-associated gene clusters from a whole gene pathway. Extracting one or a few significant gene clusters from a global pathway limits the overall false positive probability, which results in increased statistical power, and facilitates the interpretation of test results. In the present study, we applied our method to genome-wide association data for rare copy-number variations, which have been strongly implicated in common diseases. Application of our method to a simulated dataset demonstrated the high accuracy of this method in detecting disease-associated gene clusters in a whole gene pathway. Conclusions: The scan statistic approach proposed here shows a high level of accuracy in detecting gene clusters in a whole gene pathway. This study has provided a sound statistical framework for analyzing genome-wide rare CNV data by incorporating topological information on the gene pathway.
  • Measurement limit of quality-of-life questionnaires in psychiatric settings, Takeshi Nishiyama, Norio Ozaki, QUALITY OF LIFE RESEARCH, 19, (1) 25 - 30,   2010年02月, 査読有り, The extent to which psychiatric patients with a broad spectrum of disability can validly self-report on their quality of life (QOL) remains unknown. Therefore, the aim of this study was to clarify the measurement limit of a QOL questionnaire in psychiatric settings. We examined this issue by assessing data quality, reliability, and validity of the MOS 36-Item Short-Form Health Survey (SF-36) in 137 chronically mentally ill inpatients. We also attempted to identify the impact of cognitive impairment on the validity of the SF-36 and ascertain the points throughout the continuum of cognitive functioning at which self-reported data become compromised. Cognitive functioning was a major determinant of the data quality, and the psychometric properties of this instrument were marginally acceptable only in patients with Mini-Mental State Examination scores of 28 or higher. Measuring QOL reliably and validly through self-report may be possible in psychiatric patients with only very slight cognitive impairment. Therefore, interviewer-administered instruments that measure QOL may be preferable to questionnaires in psychiatric settings.
  • Major contribution of dominant inheritance to autism spectrum disorders (ASDs) in population-based families, Takeshi Nishiyama, Morihiro Notohara, Satoshi Sumi, Satoshi Takami, Hirohisa Kishino, JOURNAL OF HUMAN GENETICS, 54, (12) 721 - 726,   2009年12月, 査読有り, Results of twin studies have shown that autism spectrum disorders (ASDs) are attributable to complex multigenic interactions rather than to a single susceptibility gene. However, the growing number of distinct, individually rare genetic causes of ASDs, mostly copy number variations (CNVs), favors an alternative to the polygenic hypothesis, the two-component model, which suggests that ASDs are caused either by de novo mutation or by dominant inheritance from asymptomatic carriers of such a mutation. To verify this hypothesis, we estimated the distribution of ASD-risk among both catchment area-based families and multiplex families. Our results suggest that the models with more than three risk components are preferable to the two-component model. Our results also suggest that the largest proportion of ASD cases is caused by dominant inheritance. We additionally show that Supplementary information regarding prevalence has a crucial role in analyzing proband-ascertained data. Journal of Human Genetics (2009) 54, 721-726; doi: 10.1038/jhg.2009.105; published online 6 November 2009
  • Practice-based depression screening for psychiatry outpatients: Feasibility comparison of two-types of Center for Epidemiologic Studies Depression Scales, Takeshi Nishiyama, Norio Ozaki, Nakao Iwata, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 63, (5) 632 - 638,   2009年, 査読有り, Aims: The Center for Epidemiologic Studies Depression Scale (CES-D) has been validated to avoid misdiagnoses of major depression in routine psychiatric outpatient settings, but it was reported to be only marginally feasible in these specific settings. A briefer and simpler version, known as the 10-item CES-D, meant to attain adequate feasibility, has been validated in geriatric outpatient settings, but it has not yet been examined in psychiatry outpatient settings. The purpose of the present study was therefore to compare the feasibility, reliability, and validity of the two types of CES-D. Methods: A cross-sectional analysis was conducted of 86 consecutive outpatients in a psychiatric department in a general hospital. Results: The 10-item CES-D has a higher feasibility than the 20-item CES-D, and its internal consistency, reliability, and validity are almost identical to those of the 20-item CES-D. Conclusions: The 10-item CES-D is the better instrument to use because of the higher feasibility than the 20-item CES-D in psychiatric outpatient settings. The different answer format used in each questionnaire (a yes or no format in the former vs a multiple-choice format in the latter) may influence the feasibility, rather than the number of items.
  • Use of questionnaire infeasibility in order to detect cognitive disorders: Example of the Center for Epidemiologic Studies Depression Scale in psychiatry settings, Takeshi Nishiyama, Norio Ozaki, Nakao Iwata, PSYCHIATRY AND CLINICAL NEUROSCIENCES, 63, (1) 23 - 29,   2009年, 査読有り, To examine the extent to which cognitive disorders influenced the feasibility and accuracy of both the 20-item and the 10-item Center for Epidemiologic Studies Depression Scale (CES-D). Cross-sectional analyses of 223 first-visit patients in a psychiatric clinic and 108 patients in a psychiatric department in a general hospital were conducted. To assess the influence of age, gender, and the presence of cognitive disorders on the feasibility of both versions of the CES-D, multiple logistic regression was performed with feasibility per se as the dummy dependent variable. In order to assess the accuracy of the CES-D, receiver operating characteristic (ROC) analysis was performed. The infeasibility of both types of CES-D were so strongly associated with the presence of cognitive disorders that it can be used as an indicator of cognitive impairment. Moreover, the 10-item CES-D had almost as acceptable an internal consistency reliability as the 20-item CES-D in the study settings. Information obtained from both versions of the CES-D could be utilized fully, using infeasibility as an indicator of cognitive disorders, in psychiatry settings. Other screening instruments with as heavy a cognitive load as the CES-D can also be used in the same manner as an indicator of cognitive disorders to save the need for instruments specifically designed for dementia. Such usage can decrease the burden on both the respondent and the clinician in clinical practice.
  • Genetic correlation between autistic traits and IQ in a population-based sample of twins with autism spectrum disorders (ASDs), Takeshi Nishiyama, Hitomi Taniai, Taishi Miyachi, Koken Ozaki, Makoto Tomita, Satoshi Sumi, JOURNAL OF HUMAN GENETICS, 54, (1) 56 - 61,   2009年01月, 査読有り, Although there is accumulating evidence that intelligence quotient (IQ) indexes some aspects of the autistic spectrum disorders (ASDs), the causal relationship between autistic traits and IQ remains controversial. We examined the sources of covariation between autistic traits and IQ. As males have a four times greater risk of ASDs than females, gender-specific effects were also explored. Autistic traits and IQ were assessed in 45 twin male-male, female-female and opposite-sex pairs ascertained by the regional screening system in Nagoya, Japan. Sex-limited Cholesky structural equation models were used to decompose the correlations between autistic traits and IQ into genetic and environmental components, including sex-specific factors. Genetic correlations between autistic traits and IQ were high and not significantly different between boys and girls (-0.94 and -0.95, respectively), but genetic factors underlying the autistic traits were not entirely shared with the IQ. The individual-specific environmental correlation between autistic traits and IQ was estimated at -0.29 for boys and -0.59 for girls. There is a substantial overlap between the genetic factors that influence individual variation in autistic traits and IQ, irrespective of gender. The individual life experiences that increase autistic traits, however, have a moderate overlap with those that contribute to individual IQs.
  • Genetic influences on the broad spectrum of autism: study of proband-ascertained twins., Taniai H, Nishiyama T, Miyachi T, Imaeda M, Sumi S, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 147B, (6) 844 - 849,   2008年09月, 査読有り
  • Haplotype association between GABA(A) receptor gamma 2 subunit gene (GABRG2) and methamphetamine use disorder, T Nishiyama, M Ikeda, N Iwata, T Suzuki, T Kitajima, Y Yamanouchi, Y Sekine, M Iyo, M Harano, T Komiyama, M Yamada, Sora, I, H Ujike, T Inada, TA Furukawa, N Ozaki, PHARMACOGENOMICS JOURNAL, 5, (2) 89 - 95,   2005年, 査読有り, Psychostimulant use disorder and schizophrenia have a substantial genetic basis. Evidence from human and animal studies on the involvement of the gamma-aminobutyric acid ( GABA) system in methamphetamine ( METH) use disorder and schizophrenia is mounting. As we tested for the association of the human GABA(A) receptor gamma 2 subunit gene (GABRG2) with each diagnostic group, we used a case - control design with a set of 178 subjects with METH use disorder, 288 schizophrenics and 288 controls. First, we screened 96 controls and identified six SNPs in GABRG2, three of whom we newly reported. Next, we selected two SNPs, 315C>T and 1128+99C>A, as representatives of the linkage disequilibrium blocks for further case - control association analysis. Although no associations were found in either allelic or genotypic frequencies, we detected a haplotypic association in GABRG2 with METH use disorder, but not with schizophrenia. This finding partly replicates a recent case - control study of GABRG2 in METH use disorder, and thus indicates that GABRG2 may be one of the susceptibility genes of METH use disorder.
  • Association of a haplotype in the serotonin 5-HT4 receptor gene (HTR4) with Japanese schizophrenia., Suzuki T, Iwata N, Kitamura Y, Kitajima T, Yamanouchi Y, Ikeda M, Nishiyama T, Kamatani N, Ozaki N, American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 121B, (1) 7 - 13,   2003年08月, 査読有り
  • Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG) families, T Arinami, H Ishiguro, Y Minowa, T Ohtsuki, T Tsujita, A Imamura, T Yoshikawa, T Toyota, K Yamada, H Shimizu, K Yoshitsugu, H Shibata, Y Fujii, Y Fukumaki, N Tashiro, T Inada, Y Iijima, Y Kitao, T Furuno, T Someya, T Muratake, N Kaneko, S Tsuji, M Mineta, M Takeichi, H Ujike, Y Takehisa, Y Tanaka, K Nakata, T Kitajima, T Nishiyama, Y Yamanouchi, N Iwata, N Ozaki, K Ohara, H Shibuya, K Ohara, Y Suzuki, O Ohmori, T Shinkai, H Hori, J Nakamura, T Kojima, S Takahashi, E Tanabe, K Yara, S Nanko, H Yoneda, J Koh, J Sakai, Y Inada, Kusumi, I, K Kameda, T Koyama, H Fukuzako, T Hashiguchi, K Tanabe, Y Okazaki, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 120B, (1) 22 - 28,   2003年07月, 査読有り, To determine if there are common genes that contribute to the susceptibility for schizophrenia, first-stage genome-wide scan was carried out by genotyping 417 short-tandem repeat (STR) markers in 338 individuals from 130 families with 148 affected sib-pairs identified at 16 sites nationwide in Japan. Data was from the Japanese Schizophrenia Sib-pair Linkage Group (JSSLG), which is a multi-site collaborative study group established to create a national resource for genetic studies of schizophrenia in Japan. All subjects were Japanese, and the probands and their siblings had schizophrenia. Multipoint non-parametric linkage analysis and exclusion mapping were performed with GENEHUNTER software. Simulation studies suggested that in the absence of linkage we could expect one multipoint maximum LOD score (MLS) of 1.9 per genome scan. An MLS of 3.7 would be expected only once in every 20 genome scans and thus corresponds to a genome-wide significance of 0.05. No loci in the initial screen fulfilled the criteria for significant or suggestive evidence for linkage. Ten chromosomes (1, 2, 3, 4, 5, 8, 9, 14, 17, and 20) had at least one region with a nominal P value < 0.05. Susceptibility genes with lambda s of 3 and 2 were excluded from 98 and 70% of the genome, respectively. Our results suggest that common genes that contribute significantly to susceptibility for schizophrenia are unlikely to exist in the Japanese population. (C) 2003 Wiley-Liss, Inc.

MISC

  • Microbiome統計解析法の決定版MiRKAT現る, 西山 毅, 実験医学, 34, (9) 1422 - 14223,   2016年06月
  • 遺伝子ネットワークを用いた複合疾患遺伝子座同定法の開発, 西山 毅, 保健医療科学, 61,   2012年10月, Objective: Several statistical tests have been developed for analyzing genome-wide association data based on gene sets. Using these methods, hundreds of gene sets are typically tested, and the tested gene sets often overlap. This overlapping greatly increases the probability of generating false positives, and the results obtained are difficult to interpret, particularly when many gene sets show statistical significance. We propose a flexible statistical framework to circumvent these problems.Methods: We developed a scan statistic to extract disease-associated gene clusters from a whole gene pathway. Extracting one or a few significant gene clusters from a global pathway results in increased statistical power, and facilitates the interpretation of test results. In the present study, we applied our method to genome-wide association data for rare copy-number variations, which have been strongly implicated in complex diseases. Results: Application of our method to a simulated dataset demonstrated the high accuracy of this method in detecting disease-associated gene clusters in a whole gene pathway.Conclusion: The scan statistic approach proposed here shows a high level of accuracy in detecting gene clusters in a whole gene pathway. This study has provided a sound statistical framework for analyzing genome-wide rare CNV data by incorporating topological information on the gene pathway.
  • アスペルガー症候群の遺伝カウンセリング (特集 再びアスペルガー症候群をめぐって--成人の症例を中心に), 鷲見 聡, 谷合 弘子, 西山 毅, 臨床精神医学, 39, (9) 1157 - 1163,   2010年09月
  • 不安障害の遺伝性と分子遺伝学の現在 (特集 不安の神経科学), 西山 毅, 岩田 仲夫, 尾崎 紀夫, 分子精神医学, 2, (2) 135 - 144,   2002年04月
  • DNA pooling法 (ゲノム・ノート(6)), 西山 毅, 岩田 仲夫, 尾崎 紀夫, 分子精神医学, 2, (1) 70 - 72,   2002年01月
  • 連鎖解析(linkage analysis), 西山 毅, 岩田 仲生, 尾崎 紀夫, 分子精神医学, 1, (2) 166 - 168,   2001年03月

書籍等出版物

  • 日本版 SRS-2 対人応答性尺度マニュアル, 神尾陽子, 西山毅, 共著, 日本文化科学社,   2017年
  • 実践でわかる!Rによる統計遺伝学, 西山 毅, 監修, 丸善出版,   2016年
  • ベイズ統計分析ハンドブック, 西山 毅, 共訳, 朝倉書店,   2011年
  • 線形モデルとその拡張:一般化線形モデル,混合効果モデル,経時データのためのモデル, 西山 毅, 共訳, 株式会社シーエーシー,   2011年

競争的資金

  • 飲酒が心理社会的アウトカムに及ぼす因果効果を確証する網羅的メンデルランダム化研究, 文部科学省, 科学研究費補助金(基盤C),   2019年04月 - 2022年03月
  • 神経症傾向および抑うつ・不安が寿命に影響を与えるメカニズムの同定, メンタルヘルス岡本記念財団, 研究助成,   2017年06月 - 2019年05月
  • 児童精神科・構造化面接K-SADS-PL日本語版の開発, 市原国際奨学財団, 研究助成,   2018年04月 - 2019年03月
  • 精神疾患による病気出勤(presenteeism)を生じる要因の網羅的研究, 一般財団法人 ヘルスサイエンスセンター, 研究助成,   2018年01月 - 2019年03月
  • 全ゲノム関連解析およびそのメタアナリシスによる量的自閉症形質座の確証, 文部科学省, 科学研究費補助金 (基盤研究C),   2015年04月 - 2019年03月
  • 精神,心理,社会的要因に焦点をあてた ゲノムコホート研究, 文部科学省, 科学研究費補助金 (基盤研究B),   2014年04月 - 2019年03月
  • ゲノムワイド関連研究およびそのメタアナリシスによる 睡眠時間制御メカニズムの解明, 鈴木謙三記念医科学応用研究財団, 研究助成,   2017年11月 - 2018年10月
  • Clarifying Genetic Factors of Diseases with Unknown Etiology Based on Statistical Genetic Approaches, Rotary Foundation, Global Grant,   2015年08月 - 2016年07月
  • 拡張自閉症形質測定のための質問紙の日本語版開発および項目反応理論に基づく比較研究, 文部科学省, 科学研究費補助金 (基盤研究C),   2013年04月 - 2015年03月
  • 高機能広汎性発達障害の子どもを持つ母親に対する家族心理教育プログラム, 文部科学省, 科学研究費補助金 (基盤研究C),   2011年04月 - 2013年03月
  • 時空間情報を利用した統計遺伝学モデルの開発, 文部科学省, 科学研究費補助金 (基盤研究B),   2010年04月 - 2013年03月

社会貢献活動情報

社会貢献活動

  • 日本計算機統計学会・企画理事, 運営参加・支援,   2015年01月


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