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祖父江 和哉ソブエ カズヤ

所属部署医学研究科麻酔科学・集中治療医学分野
職名教授
メールアドレス
ホームページURLhttp://www.ncu-masui.jp/
生年月日
Last Updated :2020/06/03

研究者基本情報

基本情報

    科研費研究者番号:90264738

学位

  • 博士(医学), 名古屋市立大学

研究活動情報

論文

  • General anesthetic management of a patient with multiple chemical sensitivity for oral surgery: a case report., Aiji Sato(Boku) A, Furuno S, Kamimura Y, Sento Y, Kako E, Okuda M, Shibuya Y, Sobue K, JA Clin Reports, 5, (10) ,   2019年, 査読有り
  • Peripheral Nerve Block Provides Effective Analgesia for a Patient With Peripheral Nerve Hyperexcitability Syndrome: Isaacs Syndrome Case Report., Asai A, Kako E, Hasegawa T, Sobue K, A&A practice, 11, (10) 268 - 269,   2018年11月, 査読有り
  • General Anesthetic Management of a Child With Horseshoe Lung and Left Lung Hypoplasia for Cheiloplasty: A Case Report., Sato Boku A, Morita M, Ota H, Kamimura Y, Ito H, So M, Tamura T, Kako E, Harada J, Sobue K, A&A practice, 11, (8) 208 - 212,   2018年10月, 査読有り
  • 一地域における慢性痛への対処法とペインクリニックの認知度についての調査, 浅井 明倫, 小笠原 治, 祖父江 和哉, ペインクリニック, 39, (8) 1095 - 1097,   2018年08月
  • Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes., Yamamoto N, Ishikuro R, Tanida M, Suzuki K, Ikeda-Matsuo Y, Sobue K, Neuroscience, 385, 227 - 236,   2018年08月, 査読有り
  • Effect of two- or four-hour oral intake restriction on intraoperative intravascular volume optimization using stroke volume variation analysis: a single-blinded randomized controlled trial., Hoshika M, Fujita Y, Yoshizawa S, Harima M, Sobue K, Korean journal of anesthesiology, 71, (3) 239 - 241,   2018年06月, 査読有り
  • Detachment of Chain-Forming Neuroblasts by Fyn-Mediated Control of cell-cell Adhesion in the Postnatal Brain., Fujikake K, Sawada M, Hikita T, Seto Y, Kaneko N, Herranz-Pérez V, Dohi N, Homma N, Osaga S, Yanagawa Y, Akaike T, García-Verdugo JM, Hattori M, Sobue K, Sawamoto K, The Journal of neuroscience : the official journal of the Society for Neuroscience, 38, (19) 4598 - 4609,   2018年05月, 査読有り
  • Use of pediatric Tracheal Stoma Retainer® in a 24-year-old spinal muscular atrophy patient., Ito H, Sobue K, Pediatrics international : official journal of the Japan Pediatric Society, 60, (4) 387 - 388,   2018年04月, 査読有り
  • 外傷性脾損傷により腹部コンパートメント症候群を来した7歳女児例, 伊藤 秀和, 河野 真人, 田村 哲也, 祖父江 和哉, 日本集中治療医学会雑誌, 25, (2) 121 - 124,   2018年03月
  • General Anesthetic Management of a Patient With Hypertrophic Cardiomyopathy for Oral Surgery: Did Digitalis Contribute to Bradycardia?, Sato Boku A, Morita M, So M, Tamura T, Sano F, Shibuya Y, Harada J, Sobue K, Anesthesia progress, 65, (3) 192 - 196,   2018年, 査読有り
  • The usefulness of the McGrath MAC laryngoscope in comparison with Airwayscope and Macintosh laryngoscope during routine nasotracheal intubation: a randomaized controlled trial, Aiji Sato (Boku), Kazuya Sobue, Eisuke Kako, Naoko Tachi, Yoko Okumura, Mayuko Kanazawa, Mayumi Hashimoto, Jun Harada, BMC ANESTHESIOLOGY, 17, (1) ,   2017年12月, 査読有り, Background: McGrath MAC video laryngoscope offers excellent laryngosopic views and increases the success rate of orotracheal intubation in some cases. The aim of this study was to determine the usefulness of McGrath MAC for routine nasotracheal intubation by comparing McGrath MAC with Airway scope and Macintosh laryngoscope. Methods: A total of 60 adult patients with ASA physical status class 1 or 2, aged 20-70 years were enrolled in this study. Patients were scheduled for elective oral surgery under general anesthesia with nasotracheal intubation. Exclusion criteria included lack of consent and expected difficult airway. Patients were randomly allocated to three groups: McGrath MAC (n = 20), Airway scope (n = 20), and Macintosh laryngoscope (n = 20). After induction, nasotracheal intubation was performed by six expert anesthesiologists with more than 6 years of experience. Results: There were no significant differences in preoperative airway assessment among the three groups. Successful tracheal intubation time was 26.8 +/- 5.7 (mean +/- standard deviation) s for McGrath MAC, 36.4 +/- 11.0 s for Airway scope, and 36.5 +/- 8.9 s for Macintosh laryngoscope groups. The time for successful tracheal intubation for McGrath MAC group was significantly shorter than that for Airway scope and Macintosh laryngoscope (p < 0.01). McGrath MAC significantly improved the Cormack Lehane grade for nasotracheal intubation compared with Macintosh laryngoscope (p < 0.05). Conclusion: McGrath MAC significantly facilitates routine nasotracheal intubation compared with Airwayscope and Macintosh laryngoscope by shortening the tracheal intubation time and improving the Cormack Lehane grade.
  • 大学病院PACU (Postanesthesia Care Unit)における看護体制の現状と課題, 仙頭 佳起, 播磨 恵, 祖父江 和哉, 日本手術医学会誌, 38, (4) 291 - 298,   2017年11月
  • 小児心臓カテーテル検査・治療における鎮静に伴う呼吸障害の発生状況調査, 上村 友二, 宮津 光範, 小笠原 治, 祖父江 和哉, 日本小児救急医学会雑誌, 16, (3) 410 - 413,   2017年10月
  • Epigallocatechin gallate induces extracellular degradation of amyloid β-protein by increasing neprilysin secretion from astrocytes through activation of ERK and PI3K pathways., Yamamoto N, Shibata M, Ishikuro R, Tanida M, Taniguchi Y, Ikeda-Matsuo Y, Sobue K, Neuroscience, 362, 70 - 78,   2017年10月, 査読有り
  • The past, present and future of the postanesthesia care unit (PACU) in Japan, Yoshiki Sento, Toshiyasu Suzuki, Yasuyuki Suzuki, David A. Scott, Kazuya Sobue, JOURNAL OF ANESTHESIA, 31, (4) 601 - 607,   2017年08月, 査読有り, The postanesthesia care unit (PACU), which is run and coordinated by anesthesiologists, delivers general medical supervision as well as close and constant care to patients who have just undergone a surgical procedure under anesthesia. Although PACU management has been considered a standard procedure in many developed countries since the 1940s, Japanese hospitals have tended to cease their management, and only 16.1% of hospitals in Japan currently have PACUs. In today's efficiency-required atmosphere in Japan, we need to consider a better postoperative management method, including facilities similar to the PACU, to prevent serious adverse events and improve the postoperative outcomes and quality of life. Nevertheless, the way postoperative patients are treated and cared for, and the location in which they receive such attention, will likely need to be modified to fit the Japanese style due to Japan's unique medical systems and traditions. Here, we describe the past, present and future of the PACU and postanesthesia care in Japan compared with other countries.
  • Relationship between dexmedetomidine dose and plasma dexmedetomidine concentration in critically ill infants: a prospective observational cohort study., Fujita Y, Inoue K, Sakamoto T, Yoshizawa S, Tomita M, Toyo'oka T, Sobue K, Korean journal of anesthesiology, 70, (4) 426 - 433,   2017年08月, 査読有り
  • 心内修復術後のNoonan症候群患者の歯牙腫開窓術に対する全身麻酔経験, 佐藤 曾士, 高井 美玲, 渋谷 恭之, 原田 純, 祖父江 和哉, 有病者歯科医療, 26, (2) 98 - 102,   2017年07月
  • Two Cases of Duchenne Muscular Dystrophy That Showed Different Reactions to Nerve Stimulation During Peripheral Nerve Block: A Case Report., So M, Sugiura T, Yoshizawa S, Sobue K, A & A case reports, 9, (2) 52 - 53,   2017年07月, 査読有り
  • 手術室における誤投薬防止システムの開発 : 稼働率向上のための課題抽出, 播磨 恵, 志田 恭子, 祖父江 和哉, 日本手術医学会誌, 38, (2) 118 - 122,   2017年05月
  • Neuroprotective erythropoietin attenuates microglial activation, including morphological changes, phagocytosis, and cytokine production, Tetsuya Tamura, Mineyoshi Aoyama, Seiko Ukai, Hiroki Kakita, Kazuya Sobue, Kiyofumi Asai, BRAIN RESEARCH, 1662, 65 - 74,   2017年05月, 査読有り, Erythropoietin (EPO), a hematopoietic hormonal cytokine induced in response to hypoxia, has neuroprotective effects. EPO receptor (EPOR) is expressed in microglia, resident immune cells in the brain. However, the effect of EPO on microglial activation is not clear. In the present study, we demonstrated that the EPOR is highly expressed in microglia, rather than in neurons or astrocytes, in in vitro experiments. Therefore, we investigated whether EPO could attenuate lipopolysaccharide (LPS)-mediated activation of microglia in vitro. The BV-2 microglial cell line was treated with LPS in the absence or presence of EPO. In the presence of EPO, microglial expression of LPS-induced inflammatory cytokine genes was significantly decreased. In addition, EPO suppressed the LPS-induced phagocytic activity of BV-2 cells towards fluorescent beads, as well as induction of inducible nitric oxide synthase. In in vivo experiments, EPO significantly decreased the LPS-induced expression of inflammatory cytokine genes in mouse brains. Furthermore, morphological analysis of cortical microglia in the brains of mice stimulated with LPS revealed that combined treatment with EPO alleviated LPS-induced morphological changes in the microglia. These data indicate that EPO attenuates microglial activation, including morphological changes in vivo, phagocytosis in vitro, and the production of inflammatory cytokines in vivo and in vitro. Further investigation of EPO modulation of LPS-induced microglial activation may contribute to the development of novel neuroprotective therapies. (C) 2017 Elsevier B.V. All rights reserved.
  • The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes., Kasahara R, Yamamoto N, Suzuki K, Sobue K, Neuroscience, 340, 176 - 187,   2017年01月, 査読有り
  • Effect of different surgical procedures on the accuracy of prediction of the plasma concentration of fentanyl: comparison between mastectomy and laparoscopic prostatectomy., Fujita Y, Yoshizawa S, Hoshika M, Inoue K, Matsushita S, Oka H, Sobue K, JA clinical reports, 3, (1) ,   2017年, 査読有り
  • A Case of Delayed Emergence After Propofol Anesthesia: Genetic Analysis., Yonekura H, Murayama N, Yamazaki H, Sobue K, A & A case reports, 7, (11) 243 - 246,   2016年12月, 査読有り
  • Comparison of anesthetic management and outcomes of robot-assisted vs pure laparoscopic radical prostatectomy, Hiroshi Yonekura, Hiroyuki Hirate, Kazuya Sobue, JOURNAL OF CLINICAL ANESTHESIA, 35, 281 - 286,   2016年12月, 査読有り, Study objective: Limited data are available regarding the anesthetic management and outcome of patients undergoing pure laparoscopic radical prostarectomy (LRP) and robotic-assisted LRP (RALP). Therefore, our primary objective was to compare the anesthetic management between these 2 groups. Our secondary objective was to determine the incidence of adverse outcomes associated with RALP, which requires an extreme Trendelenburg position. Design: A retrospective observational study. Setting: University teaching hospital. Patients: A total of 223 men, consisting of 97 LRP patients and 126 RALP patients, treated during a 3-year period (January 2010-December 2012) were retrospectively studied. Interventions: None. Measurements: Information on patient demographics, type of anesthesia, anesthetic/pneumoperitoneum/ surgical times, intraoperative fluids and blood products, estimated blood loss, intraoperative and postoperative opioid use, postoperative analgesic consumption, length of stay in the postanesthesia care unit, postoperative complications, and hospital stays was collected and compared. Main results: The estimated blood loss was higher in LRP patients than in RALP patients (median, 550 mL vs 200 mL; P < .001). Likewise, 24% of the LRP patients received intraoperative transfusions compared with 0.79% of the RALP patients (P < .001). The RALP patients had a longer anesthesia time (median, 276 vs 259 minutes; P = .032) and a greater intraoperative use of opioids (P < .001). The incidence of complications was similar in both groups with the exception of postoperative nausea and vomiting, which were observed more frequently among the RALP patients than among the LRP patients (33% vs 16%; P = .007). Conclusions: This is the first report to compare the anesthetic management of RALP vs LRP. Anesthesiologists can expect RALP surgery to be associated with less blood loss and a need for fewer blood products than traditional LRP surgery. The anesthetic outcome of RALP was generally satisfactory except for a high incidence of postoperative nausea and vomiting. (C) 2016 Elsevier Inc. All rights reserved.
  • 重症小児の瞳孔観察における瞳孔記録計と従来法との比較, 上村 友二, 宮津 光範, 祖父江 和哉, 日本集中治療医学会雑誌, 23, (6) 677 - 678,   2016年11月
  • Guidelines for parenteral fluid management for terminal cancer patients, Takashi Higashiguchi, Junichi Ikegaki, Kazuya Sobue, Yoichiro Tamura, Nobuhisa Nakajima, Akihiko Futamura, Mitsunori Miyashita, Naoharu Mori, Akio Inui, Keiichiro Ohta, Toyoshi Hosokawa, JAPANESE JOURNAL OF CLINICAL ONCOLOGY, 46, (11) 986 - 992,   2016年11月, 査読有り, Japanese Society for Palliative Medicine released a revised edition of the Guidelines for Parenteral Therapy in Terminal Cancer Patients, which are based on medical evidence and consider the pathologic features of cachexia.Japan's first guidelines for parenteral fluid management for terminal cancer patients were issued in 2006. These guidelines focused on the fluid levels to administer to patients with a remaining life expectancy of 1-2 months. However, recent refinement of the concept of cachexia is prompting caregivers worldwide to rethink parenteral fluid management for terminal cancer patients. Our objective was to develop guidelines for parenteral fluid management for terminal cancer patients with a remaining life expectancy of 1 month, a point when cachexia generally begins to severely adversely affect the body. The Japanese Society for Palliative Medicine appointed a Guidelines Working Practitioner Group consisting of a multidisciplinary team of specialists. In response to 26 clinical questions on parenteral fluid management for terminal cancer patients, the Working Group used the Delphi method to reach consensus on the recommendability and evidence level of 89 relevant manuscripts identified through a systematic literature review. The Working Group then had an outside committee reviews the draft guidelines validity before authoring the final version. The resulting clinically aligned guidelines contain specific recommendations (25 recommendations on physical suffering/remaining life expectancy, 10 nursing-related recommendations and 4 ethical recommendations) assessed using the Delphi method and by an outside committee. Japanese Society for Palliative Medicine released a revised edition of the Guidelines for Parenteral Fluid Management for Terminal Cancer Patients, which are based on medical evidence and consider the pathologic features of cachexia. We recommend that caregivers carefully evaluate the clinical usefulness of the guidelines.
  • 急激な血清ナトリウム値の低下により脳浮腫が増悪したインフルエンザ脳症の一例, 伊藤 秀和, 祖父江 和哉, 日本小児麻酔学会誌, 22, (1) 224 - 227,   2016年09月
  • 当院における小児心臓カテーテル検査・治療の管理体制とコードブルー発動状況の調査, 上村 友二, 宮津 光範, 祖父江 和哉, 日本小児麻酔学会誌, 22, (1) 257 - 259,   2016年09月
  • Simvastatin and atorvastatin facilitates amyloid β-protein degradation in extracellular spaces by increasing neprilysin secretion from astrocytes through activation of MAPK/Erk1/2 pathways., Yamamoto N, Fujii Y, Kasahara R, Tanida M, Ohora K, Ono Y, Suzuki K, Sobue K, Glia, 64, (6) 952 - 962,   2016年06月, 査読有り
  • 手術室の誤薬・誤投与防止対策の現状調査 : (公社)日本麻酔科学会安全委員会 誤薬防止のためのシリンジラベルの薬効別色分けの提言検討ワーキンググループ報告, 志田 恭子, 鈴木 利保, 須加原 一博, 祖父江 和哉, 麻酔, 65, (5) 542 - 547,   2016年05月, 査読有り
  • Effects of landiolol on refractory tachyarrhythmia after total cavopulmonary connection: a retrospective, observational, cohort study, Kentaro Miyake, Yoshihito Fujita, Saya Yoshizawa, Maiko Tomita, Mitsunori Miyazu, Yoshiki Sento, Shinichiro Yoshimura, Kazuya Sobue, JOURNAL OF ANESTHESIA, 30, (2) 331 - 336,   2016年04月, 査読有り, The onset of tachyarrhythmia after the Fontan procedure (total cavopulmonary connection; TCPC) should be considered a medical emergency. Landiolol is an ultra-short-acting beta 1-selective blocker whose effect on tachyarrhythmia after TCPC is unclear. We evaluated the efficacy and safety of landiolol for tachyarrhythmia after TCPC. Consecutive patients undergoing TCPC were enrolled from January 2007 to December 2011. Of 435 pediatric open heart surgeries, 28 patients underwent TCPC. Of the 28 patients, 13 were treated with landiolol for critical tachyarrhythmia. Excluding three patients who received landiolol during surgery, we investigated the remaining 10 patients and statistical analysis was performed without a 10-year-old patient as outlier. The median age was 4.08 years. The subjects comprised five patients with sinus tachycardia, four with junctional ectopic tachycardia and one with paroxysmal supraventricular tachycardia. The initial dose was 4.7 +/- A 2.3 mu g/kg/min, without a loading dose. Landiolol reduced the heart rate from 151.8 +/- A 23.2 at the start to 132.9 +/- A 20.0 at 1 h and 126.1 +/- A 24.9 at 2 h (P < 0.01 and P < 0.01, respectively), without blood pressure decrease (P = 0.235). Landiolol was effective in treating critical tachyarrhythmia without hemodynamic deterioration. We believe that landiolol is a promising option for postoperative tachyarrhythmia after the Fontan procedure.
  • 敗血症性ショックと多臓器不全を呈して救命できなかった類鼻疽の1例, 中井 俊宏, 稲垣 雅昭, 井上 雅史, 衣笠 梨絵, 山崎 潤二, 祖父江 和哉, 日本救急医学会中部地方会誌, 11, 33 - 37,   2015年12月
  • 大学病院ICUにおける最近5年間の小児veno arterial extracorporeal membrane oxygenationの稼働実績と今後の課題, 仙頭 佳起, 宮津 光範, 竹内 直子, 太田 晴子, 佐野 文昭, 上村 友二, 藤田 義人, 祖父江 和哉, 日本集中治療医学会雑誌, 22, (6) 505 - 511,   2015年11月
  • 小児 ICUにおけるトルバプタンの使用経験, 上村 友二, 宮津 光範, 祖父江 和哉, 日本集中治療医学会雑誌, 22, (6) 527 - 530,   2015年11月
  • Estimation of the success rate of anesthetic management for thymectomy in patients with myasthenia gravis treated without muscle relaxants: a retrospective observational cohort study, Yoshihito Fujita, Satoru Moriyama, Satoshi Aoki, Saya Yoshizawa, Maiko Tomita, Taiki Kojima, Yukiko Mori, Naoko Takeuchi, Min-Hye So, Motoki Yano, Kazuya Sobue, JOURNAL OF ANESTHESIA, 29, (5) 794 - 797,   2015年10月, 査読有り, Although maintaining anesthesia for myasthenia gravis (MG) with minimal muscle relaxants (MR) is common, the success rate of anesthetic management for MG without MR is not clear. We therefore retrospectively examined the success rate of anesthetic management for MG without MR among 66 consecutive cases of thymectomy for MG performed at our hospital between January 2004 and April 2010, before approval of using sugammadex. A total of 60 patients (90.9 %) were treated without MR (N group). Among the 60 cases, 17 (28.3 %) patients were not extubated in the operating room due to postoperative respiratory depression or other reasons. Therefore, the success rate of anesthetic management for thymectomy in patients with MG without treating MR was 71.7 % (43/60) [95 % confident interval (CI): 65.9-77.5 %]. The reasons for using MR included coughing at intubation in one case, bucking during surgery in two cases, and MR was considered to be safer by the attending anesthesiologist in three cases. The number of cases of impossible extubation requiring ventilation on that day was three in the N group and none in the R group. Finally, the success rate of anesthetic management for MG without MR was estimated to be 71.1 % (95 % CI: 65.9-77.5 %).
  • 重症患者における NT-proBNP 簡易迅速測定装置の測定値の妥当性, 小宮 良輔, 吉澤 佐也, 幸村 英文, 藤田 義人, 祖父江 和哉, Cardiovascular Anesthesia, 19, (1) 21 - 24,   2015年09月
  • 食道切除術における術後せん妄の発生頻度と関連因子の検討, 米倉 寛, 平手 博之, 祖父江 和哉, 麻酔, 64, (6) 597 - 602,   2015年06月
  • A short period of fasting before surgery conserves basal metabolism and suppresses catabolism according to indirect calorimetry performed under general anesthesia, Shinichiro Yoshimura, Yoshihito Fujita, Hiroyuki Hirate, Nobuyoshi Kusama, Takafumi Azami, Kazuya Sobue, JOURNAL OF ANESTHESIA, 29, (3) 453 - 456,   2015年06月, 査読有り, It is recommended that the period of fasting before elective surgery should be shortened to facilitate a rapid recovery by preventing catabolism. We examined the effects of a short period of fasting on metabolism by performing indirect calorimetry (IC) under general anesthesia. A prospective observational study involving 26 consecutive patients who underwent elective surgery and whose metabolism was evaluated using IC during anesthesia was conducted. The patients were divided into two groups, those who fasted for < 8 h (group S) and those who fasted for > 10 h (group L). Oxygen consumption, the volume of carbon dioxide emissions (VCO2), the respiratory quotient (RQ), resting energy expenditure (REE), and basal energy expenditure (BEE) were compared. The REE, VCO2, and RQ of group L (17.7 +/- A 2.3 kcal/kg/day, 118.5 +/- A 20.8 ml/min, and 0.71 +/- A 0.12, respectively) were significantly lower than those of group S (19.7 +/- A 2.3 kcal/kg/day, 143.6 +/- A 30.9 ml/min, and 0.81 +/- A 0.09, respectively) (P < 0.05). In group L, the relationship between REE and BEE was weaker (r (2) = 0.501) and the BEE-REE slope was less steep (REE = 0.419BEE + 509.477) than those seen in group S (r (2) = 0.749 and REE = 1.113BEE - 376.111, respectively). Our findings suggest that a short period of fasting (< 8 h) before surgery is more strongly associated with the conservation of basal metabolism.
  • 小児泌尿器科におけるロボット支援下腹腔鏡手術と従来の腹腔鏡手術に対する麻酔管理の比較, 辻 達也, 宮津 光範, 祖父江 和哉, 日本臨床麻酔学会誌, 35, (3) 295 - 300,   2015年05月
  • Midazolam inhibits the formation of amyloid fibrils and GM1 ganglioside-rich microdomains in presynaptic membranes through the gamma-aminobutyric acid A receptor., Yamamoto N, Arima H, Sugiura T, Hirate H, Kusama N, Suzuki K, Sobue K, Biochemical and biophysical research communications, 457, (4) 547 - 553,   2015年02月, 査読有り
  • Efficacy of an enteral feeding protocol for providing nutritional support after paediatric cardiac surgery., Yoshimura S, Miyazu M, Yoshizawa S, So M, Kusama N, Hirate H, Sobue K, Anaesth Intensive Care., 43, (5) 587 - 593,   2015年, 査読有り
  • Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway., Yamamoto N, Tanida M, Kasahara R, Sobue K, Suzuki K, Journal of neurochemistry, 131, (3) 323 - 332,   2014年11月, 査読有り
  • 超音波ガイド下腹横筋膜面ブロックの腹部大動脈瘤に対する人工血管置換術後鎮痛方法としての有用性, 南 悦子, 川島 沙織, 加藤 妙, 伊藤 恭史, 森島 徹朗, 伊藤 彰師, 祖父江 和哉, 麻酔, 63, (10) 1089 - 1092,   2014年10月
  • カルバマゼピン内服治療中に重度低ナトリウム血症をきたした顔面帯状疱疹痛の1症例, 浅井 明倫, 杉浦 健之, 徐 民恵, 平手 博之, 藤田 義人, 祖父江 和哉, 日本ペインクリニック学会誌, 21, (4) 537 - 538,   2014年10月
  • 術後患者における病棟での重篤な有害事象を減らすためにPostanesthesia care unit (PACU)が果たせる役割, 仙頭 佳起, 鈴木 利保, 祖父江 和哉, 蘇生, 33, (2) 59 - 62,   2014年09月
  • Speed control for neuronal migration in the postnatal brain by Gmip-mediated local inactivation of RhoA, Haruko Ota, Takao Hikita, Masato Sawada, Tomoki Nishioka, Mami Matsumoto, Masayuki Komura, Akihisa Ohno, Yukiyo Kamiya, Takuya Miyamoto, Naoya Asai, Atsushi Enomoto, Masahide Takahashi, Kozo Kaibuchi, Kazuya Sobue, Kazunobu Sawamoto, NATURE COMMUNICATIONS, 5,   2014年07月, 査読有り, Throughout life, new neurons generated in the ventricular-subventricular zone take the long journey to the olfactory bulb. The intracellular mechanisms that precisely control the neurons' migration speed, enabling their well-organized movement, remain unclear. Rho signalling is known to affect the morphology and movement of various cell types, including neurons. Here we identify Gem-interacting protein (Gmip), a RhoA-specific GTPase-activating protein, as a key factor in saltatory neuronal migration. RhoA is activated at the proximal leading process of migrating neurons, where Gmip is also localized and negatively regulates RhoA. Gmip controls the saltatory movement of neurons that regulate their migration speed and 'stop' positions in the olfactory bulb, thereby altering the neural circuitry. This study demonstrates that Gmip serves as a brake for the RhoA-mediated movement of neuronal somata, and highlights the significance of speed control in the well-organized neuronal migration and the maintenance of neuronal circuits in the postnatal brain.
  • Tidal volume and airway pressure under percutaneous transtracheal ventilation without a jet ventilator: comparison of high-flow oxygen ventilation and manual ventilation in complete and incomplete upper airway obstruction models, Nobuko Sasano, Akemi Tanaka, Ai Muramatsu, Yoshihito Fujita, Shoji Ito, Hiroshi Sasano, Kazuya Sobue, JOURNAL OF ANESTHESIA, 28, (3) 341 - 346,   2014年06月, 査読有り, Percutaneous transtracheal ventilation (PTV) can be life-saving in a cannot ventilate, cannot intubate situation. The aim of this study was to investigate the efficacy of PTV by measuring tidal volumes (VTs) and airway pressure (Paw) in high-flow oxygen ventilation and manual ventilation using a model lung. We examined 14G, 16G, 18G, and 20G intravenous catheters and minitracheotomy catheters. In high-flow oxygen ventilation, the flow was set to 10 L/min, while the inspiratory:expiratory phases (I:E) were 1 s:4 s in the complete upper airway obstruction model and 1 s:1 s in the incomplete obstruction model. In manual ventilation, I:E were 2 s:4 s in the complete obstruction model and 2 s:3 s in the incomplete obstruction model. We ventilated through each catheter for 2 min and measured VT and Paw. In high-flow ventilation, the average VTs were approximately 150 ml and < 100 ml with 14G catheters in complete and incomplete upper airway obstruction, respectively. The VTs obtained were reduced when the bore size was decreased. In manual ventilation, the average VTs were over 300 ml and approximately 260 ml with 14G catheters in complete and incomplete upper airway obstruction, respectively. In high-flow ventilation, the airway pressure tended to be higher. The minitracheotomy catheters produced over 800 ml of VT and created almost no positive end-expiratory pressure. High-flow ventilation tends to result in higher airway pressure despite a smaller VT, which is probably due to a PEEP effect caused by high flow.
  • 国際栄養調査から見える本邦ICUにおける栄養療法の現状と問題点, 東別府 直紀, 井澤 純一, Daren K. Heyland, 讃井 將満, 祖父江 和哉, 佐藤 武揚, 塩塚 潤二, 水野 篤, 安田 英人, 三宅 健太郎, 徳平 夏子, 日本集中治療医学会雑誌, 21, (3) 243 - 252,   2014年05月
  • Leptin inhibits amyloid β-protein degradation through decrease of neprilysin expression in primary cultured astrocytes., Yamamoto N, Tanida M, Ono Y, Kasahara R, Fujii Y, Ohora K, Suzuki K, Sobue K, Biochemical and biophysical research communications, 445, (1) 214 - 217,   2014年02月, 査読有り
  • マネキンを用いたエアウェイスコープ補助下経鼻気管挿管の検討, 杉浦 健之, 大内田 絵美, 平手 博之, 有馬 一, 笹野 寛, 祖父江 和哉, 日本臨床麻酔学会誌, 34, (1) 95 - 100,   2014年01月
  • IV injection of polystyrene beads for mouse model of sepsis causes severe glomerular injury., Arima H, Hirate H, Sugiura T, Suzuki S, Takahashi S, Sobue K, Journal of intensive care, 2, (1) ,   2014年, 査読有り
  • Markedly elevated procalcitonin in early postoperative period in pediatric open heart surgery: a prospective cohort study., Minami E, Ito S, Sugiura T, Fujita Y, Sasano H, Sobue K, Journal of intensive care, 2, (1) ,   2014年, 査読有り
  • Proteomic analysis of Girdin-interacting proteins in migrating new neurons in the postnatal mouse brain, Haruko Ota, Takao Hikita, Tomoki Nishioka, Mami Matsumoto, Jun Ito, Naoya Asai, Atsushi Enomoto, Masahide Takahashi, Kozo Kaibuchi, Kazuya Sobue, Kazunobu Sawamoto, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 442, (1-2) 16 - 21,   2013年12月, 査読有り, Neural stem cells continuously generate new neurons in the ventricular-subventricular zone (V-SVZ) of the postnatal and adult mammalian brain. New neurons born in the rodent V-SVZ migrate toward the olfactory bulb (OB), where they differentiate into interneurons. To reveal novel intracellular molecular mechanisms that control postnatal neuronal migration, we performed a global proteomic search for proteins interacting with Girdin, an essential protein for postnatal neuronal migration. Using GST pull-down and LC-MS/MS shotgun analysis, we identified cytoskeletal proteins, cytoskeleton-binding proteins, and signal-transduction proteins as possible participants in neuronal migration. Our results suggest that Girdin and Girdin-interacting proteins control neuronal migration by regulating actin and/or microtubule dynamics. (C) 2013 Elsevier Inc. All rights reserved.
  • 敗血症患者におけるhigh flow-volume large size polymethyl methacrylate-hemodiafiltration(high performance-HDF, HP-HDF)施行時のプロカルシトニン値の変動, 田村 哲也, 坪内 宏樹, 新美 太祐, 川出 健嗣, 辻 麻衣子, 野手 英明, 松永 安美香, 祖父江 和哉, 日本集中治療医学会雑誌, 20, (4) 620 - 624,   2013年10月
  • 体幹の痛みで発症したサルコイドーシスの1症例, 徐 民恵, 杉浦 健之, 浅井 明倫, 薊 隆文, 祖父江 和哉, ペインクリニック, 34, (9) 1302 - 1304,   2013年09月
  • 麻酔中の誤薬防止のための薬剤シリンジラベル標準カラーコードについての史的研究, 志田 恭子, 祖父江 和哉, 平手 博之, 有馬 一, 藤田 義人, 笹野 寛, 日本臨床麻酔学会誌, 33, (5) 808 - 814,   2013年09月
  • 小児心臓外科術後に悪性高熱症の診断に難渋した1症例, 吉村 真一朗, 小嶋 大樹, 平手 博之, 杉浦 健之, 有馬 一, 祖父江 和哉, 日本臨床麻酔学会誌, 33, (5) 820 - 825,   2013年09月
  • 高度脊椎変形により少量の硬膜外血腫で神経症状を呈した1症例, 蓑輪 尭久, 平手 博之, 杉浦 健之, 笹野 寛, 祖父江 和哉, 薊 隆文, 日本臨床麻酔学会誌, 33, (5) 826 - 829,   2013年09月
  • Development of a stable isotope dilution UPLC-MS/MS method for quantification of dexmedetomidine in a small amount of human plasma, Koichi Inoue, Tasuku Sakamoto, Yoshihito Fujita, Saya Yoshizawa, Maiko Tomita, Jun Zhe Min, Kenichiro Todoroki, Kazuya Sobue, Toshimasa Toyo'oka, BIOMEDICAL CHROMATOGRAPHY, 27, (7) 853 - 858,   2013年07月, 査読有り, Dexmedetomidine (Dex) is a selective central 2-agonist with anesthetic properties and has been used in clinical practice for sedation in the intensive care unit (ICU) after operations. In this study, an analytical assay for the determination of Dex in a small amount of plasma was developed for the application to pediatric ICU trials. The quantification of Dex was constructed using the original stable isotope Dex-d3 for electrospray ionization-tandem mass spectrometry (ESI-MS/MS) in the selected reaction monitoring mode. A rapid ultra-performance liquid chromatography technique was adopted using ESI-MS/MS with a runtime of 3 min. Efficacious concentration levels (50 pg/mL to 5 ng/mL) could be evaluated using a very small amount of plasma (10 L) from patients. The lower limit of the quantification was 5 pg/mL in the plasma (100 mu L). For sample preparation, a solid-phase extraction was used along with the OASIS-HLB cartridge type. Recovery values ranged from 98.8 to 100.3% for the intra- [relative standard deviation (RSD), 0.9-1.3%] and inter- (RSD, 0.9-1.5%) day assays. A stable test had recovery values that ranged from 97.8 to 99.7% with an RSD of 1.0-1.9% for the process/wet extract, bench-top, freeze-thaw and long-term tests. This method was used to measure the Dex levels in plasma from pediatric ICU patients. In the clinical ICU trial, the small amount of blood (approximate plasma volume, 200 L) remaining from blood gas analysis was reused and targeted for the clinical analysis of Dex in plasma. Copyright (c) 2013 John Wiley & Sons, Ltd.
  • Propofol and thiopental suppress amyloid fibril formation and GM1 ganglioside expression through the γ-aminobutyric acid A receptor., Yamamoto N, Arima H, Sugiura T, Hirate H, Taniura H, Suzuki K, Sobue K, Anesthesiology, 118, (6) 1408 - 1416,   2013年06月, 査読有り
  • Ketamine reduces amyloid β-protein degradation by suppressing neprilysin expression in primary cultured astrocytes., Yamamoto N, Arima H, Naruse K, Kasahara R, Taniura H, Hirate H, Sugiura T, Suzuki K, Sobue K, Neuroscience letters, 545, 54 - 58,   2013年06月, 査読有り
  • Age-related requisite concentration of sevoflurane for adequate sedation with combined epidural-general anesthesia., Fujita Y, Kondo A, Yamauchi H, Kako E, Sobue K, Korean journal of anesthesiology, 64, (6) 489 - 493,   2013年06月, 査読有り
  • Spinal cord stimulation for a woman with complex regional pain syndrome who wished to get pregnant, Shoji Ito, Takeshi Sugiura, Takafumi Azami, Hiroshi Sasano, Kazuya Sobue, JOURNAL OF ANESTHESIA, 27, (1) 124 - 127,   2013年02月, 査読有り, A woman with complex regional pain syndrome (CRPS) in the right lower extremity who wished to discontinue medications to get pregnant underwent implantation of a spinal cord stimulation system (SCS). An electrode lead was placed at Th10-11 in the epidural space, accessed via the L2-3 interspace with a paramedian approach, and a pulse generator was implanted in the left buttock. She kept the SCS on 24 h a day. After she had experienced several chemical abortions, finally she got pregnant via artificial insemination. She had an uneventful delivery of a healthy baby by cesarean resection under spinal anesthesia. In a patient with CRPS who has an implanted SCS system and wishes to get pregnant, the electrode lead into the low thoracic epidural space should be accessed via the high lumbar intervertebral space in consideration of a future requirement for spinal or epidural anesthesia for cesarean section. The generator should be placed in the buttock to prevent impairment of the SCS system being caused by the enlarged abdomen during pregnancy. Although we were apprehensive of adverse effects owing to the electromagnetic field force and change of blood flow in the pelvic viscera, our patient had a successful delivery. SCS is a favorable option for patients with CRPS who wish to get pregnant.
  • A comparison between dosages and plasma concentrations of dexmedetomidine in clinically ill patients: a prospective, observational, cohort study in Japan., Fujita Y, Inoue K, Sakamoto T, Yoshizawa S, Tomita M, Maeda Y, Taka H, Muramatsu A, Hattori Y, Hirate H, Toyo'oka T, Sobue K, Journal of intensive care, 1, (1) ,   2013年, 査読有り
  • Latent myasthenia gravis revealed by protracted postoperative effect of non-depolarizing neuromuscular blockade, Shoji Ito, Yoshihito Fujita, Hiroshi Sasano, Kazuya Sobue, JOURNAL OF ANESTHESIA, 26, (6) 953 - 954,   2012年12月, 査読有り
  • Subventricular Zone-Derived Oligodendrogenesis in Injured Neonatal White Matter in Mice Enhanced by a Nonerythropoietic Erythropoietin Derivative, Eisuke Kako, Naoko Kaneko, Mineyoshi Aoyama, Hideki Hida, Hirohide Takebayashi, Kazuhiro Ikenaka, Kiyofumi Asai, Hajime Togari, Kazuya Sobue, Kazunobu Sawamoto, STEM CELLS, 30, (10) 2234 - 2247,   2012年10月, 査読有り, Perinatal hypoxia-ischemia (HI) frequently causes white-matter injury, leading to severe neurological deficits and mortality, and only limited therapeutic options exist. The white matter of animal models and human patients with HI-induced brain injury contains increased numbers of oligodendrocyte progenitor cells (OPCs). However, the origin and fates of these OPCs and their potential to repair injured white matter remain unclear. Here, using cell-type- and region-specific genetic labeling methods in a mouse HI model, we characterized the Olig2-expressing OPCs. We found that after HI, Olig2+ cells increased in the posterior part of the subventricular zone (pSVZ) and migrated into the injured white matter. However, their oligodendrocytic differentiation efficiency was severely compromised compared with the OPCs in normal tissue, indicating the need for an intervention to promote their differentiation. Erythropoietin (EPO) treatment is a promising candidate, but it has detrimental effects that preclude its clinical use for brain injury. We found that long-term postinjury treatment with a nonerythropoietic derivative of EPO, asialo-erythropoietin, promoted the maturation of pSVZ-derived OPCs and the recovery of neurological function, without affecting hematopoiesis. These results demonstrate the limitation and potential of endogenous OPCs in the pSVZ as a therapeutic target for treating neonatal white-matter injury. STEM Cells2012;30:22342247
  • Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes., Yamamoto N, Matsubara T, Sobue K, Tanida M, Kasahara R, Naruse K, Taniura H, Sato T, Suzuki K, Journal of neurochemistry, 121, (4) 619 - 628,   2012年05月, 査読有り
  • A New Enteral Diet, MHN-02, Which Contains Abundant Antioxidants and Whey Peptide, Protects Against Carbon Tetrachloride-Induced Hepatitis, Takehiko Takayanagi, Hajime Sasaki, Akihiro Kawashima, Yuichiro Mizuochi, Hiroyuki Hirate, Takeshi Sugiura, Takafumi Azami, Kiyofumi Asai, Kazuya Sobue, JOURNAL OF PARENTERAL AND ENTERAL NUTRITION, 35, (4) 516 - 522,   2011年07月, 査読有り, Background: Inflammatory or oxidative stress is related to various diseases, including not only inflammatory diseases, but also diabetes, cancer, and atherosclerosis. The aim of this study was to evaluate the anti-inflammatory effects of a new enteral diet, MHN-02, which contains abundant antioxidants and whey peptide. The study also investigated the ability of MHN-02 to attenuate lethality, liver injury, the production of inflammatory cytokines, and the production of oxidized products using a carbon tetrachloride-induced rat model of severe fulminant hepatitis. Methods: Male Sprague-Dawley rats were fed either a control diet or the MHN-02 diet for 14 days and injected with 2 mL/kg of carbon tetrachloride. Survival of rats was monitored from day 0 to day 3. To evaluate liver injury, inflammation, and oxidative stress, blood and liver samples were collected, and aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, interleukin 6, tumor necrosis factor-alpha, and superoxide dismutase activity as a free radical scavenger were measured. A portion of the liver was evaluated histologically. Results: The survival rates of rats receiving the MHN-02 diet and the control diet were 90% and 55%, respectively. In the MHN-02 diet group, levels of serum liver enzymes and serum cytokines were significantly lower than in the control group. Superoxide dismutase activity in the MHN-02 diet was significantly higher in the MHN-02 group. Pathological lesions were significantly larger in the control group. Conclusion: Supplementation of enteral diets containing whey peptide and antioxidants may protect against severe hepatitis. (JPEN J Parenter Enteral Nutr. 2011;35:516-522)
  • Optimal prediction of the central venous catheter insertion depth on a routine chest x-ray, Yumiko Uchida, Masaki Sakamoto, Hiroki Takahashi, Yoichi Matsuo, Hitoshi Funahashi, Hiroshi Sasano, Kazuya Sobue, Hiromitsu Takeyama, NUTRITION, 27, (5) 557 - 560,   2011年05月, 査読有り, Objective: Cardiac tamponade is a serious complication of central venous catheter (CVC) insertion. The position of the carina has been shown to be near the pericardial reflection and can easily be identified as a landmark on routine chest x-ray (CXR). The purpose of this study was to show a simple way to predict optimal CVC depth, thereby facilitating safe positioning of the CVC tip. Methods: Subjects included 119 inpatients undergoing gastroenterologic surgery. Central venous catheterization was performed through the right internal jugular vein or the right subclavian vein. The insertion depth was measured. Postoperatively, the CVC tip position was confirmed by CXR and the distance between the CVC tip and the carina was measured. We compared the "original measurement" up to the carina from the insertion point with the "calculated measurement" derived by adding half the length of the right clavicle and the vertical length between the sternal head of the right clavicle and the carina on the CXR. Results: There was a significant correlation between the original measurement and the calculated measurement when performed through the internal jugular vein and the subclavian vein. Conclusion: The appropriate length of CVC inserted through the right internal jugular vein or right subclavian vein could be estimated by the calculated measurement of adding half the length of the right clavicle and the vertical length between the sternal head of the right clavicle and the carina. (C) 2011 Elsevier Inc. All rights reserved.
  • Prolonged exposure to ammonia increases extracellular glutamate in cultured rat astrocytes, Kentaro Ohara, Mineyoshi Aoyama, Masataka Fujita, Kazuya Sobue, Kiyofumi Asai, NEUROSCIENCE LETTERS, 462, (2) 109 - 112,   2009年09月, 査読有り, Abnormal alteration of brain function is a characteristic complication of hepatic encephalopathy in both acute and chronic liver failure. Previous studies suggest that the pathogenesis of hepatic encephalopathy involves chronic glial edema with subsequent alteration of glioneuronal communication, N-methyl-D-aspartate (NMDA) receptor activation, and oxidative/nitrosative stress. In the present study, we investigated extracellular glutamate levels in cultured astrocytes under prolonged exposure to ammonia. Using an enzyme-linked high-performance liquid chromatography assay to detect glutamate, prolonged (48 h) exposure of cultured astrocytes to ammonia resulted in a concentration- and time-dependent increase in extracellular glutamate. Similar increases were observed when ammonia-containing medium (pH 7.8) was adjusted to the pH of control medium (pH 7.4), indicating that the effect is not due to pH. Treatment of astrocytes with an antioxidant (L-ascorbic acid), an NADPH oxidase inhibitor (apocynin), a Ca(2+) chelator (BAPTA-AM), an NMDA receptor antagonist (NK801), or a mitochondrial permeability transition inhibitor (cyclosporine A) suppressed the increase of extracellular glutamate in response to prolonged ammonia exposure. Prolonged exposure to ammonia increased extracellular glutamate through the NMDA receptor, increased intracellular Ca(2+) levels, and upregulation of excitatory amino acids. The addition of ATP further increased extracellular glutamate levels in astrocytes subjected to prolonged ammonia treatment (5 mM, 48 h) in a dose-dependent manner. These results indicate that the deregulation of glutamate release from astrocytes may contribute to the dysfunction of glutamatergic neurons in patients with acute liver failure (ALF). (c) 2009 Elsevier Ireland Ltd. All rights reserved.
  • A Novel Skin-Traction Method Is Effective for Real-Time Ultrasound-Guided Internal Jugular Vein Catheterization in Infants and Neonates Weighing Less Than 5 Kilograms, Masato Morita, Hiroshi Sasano, Takafumi Azami, Nobuko Sasano, Yoshihito Fujita, Shoji Ito, Takeshi Sugiura, Kazuya Sobue, ANESTHESIA AND ANALGESIA, 109, (3) 754 - 759,   2009年09月, 査読有り, BACKGROUND: Internal jugular vein (IJV) catheterization in pediatric patients is sometimes difficult because of the small sizes of veins and their collapse during catheterization. To facilitate ITV catheterization, we developed a novel skin-traction method (STM), in which the point of puncture of the skin over the IJV is stretched upward with tape during catheterization. In this study, we examined whether the STM increases the cross-sectional area of the vein and thus facilitates catheterization. METHODS: This was a prospective study conducted from December 2006 to June 2008. We enrolled 28 consecutive infants and neonates weighing <5 kg who underwent surgery for congenital heart disease. The patients were randomly assigned to a group in which STM was performed (STM group) or a group in which it was not performed (non-STM group). The cross-sectional area and diameter of the right IJV in the flat position and 10 degrees Trendelenburg position with and without applying STM were measured. We determined time from first skin puncture to the following: (a) first blood back flow, (b) insertion of guidewire, and (c) insertion of catheter. Number of punctures, success rate, complications, and degree of IJV collapse during advancement of the needle (estimated as decrease of anteroposterior diameter during advancement of the needle compared with the diameter before advancement) were also examined. RESULTS: STM significantly increased the cross-sectional area and the anteroposterior diameter of the IJV in both positions. The time required to insert the catheter was significantly shorter in the STM group, probably mainly due to a shorter guidewire insertion time. The degree of IJV collapse during advancement of the needle was much lower in the STM group. CONCLUSIONS: STM facilitates IJV catheterization in infants and neonates weighing <5 kg by enlarging the IJV and preventing vein collapse. (Anesth Analg 2009;109:754-9)
  • Donepezil Improves Cognitive Function in Mice by Increasing the Production of Insulin-Like Growth Factor-I in the Hippocampus, Noriko Narimatsu, Naoaki Harada, Hiroki Kurihara, Naomi Nakagata, Kazuya Sobue, Kenji Okajima, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 330, (1) 2 - 12,   2009年07月, 査読有り, Insulin-like growth factor-I (IGF-I) exerts beneficial effects on cognitive function. The selective acetylcholinesterase inhibitor donepezil increases serum IGF-I levels in elderly subjects. Because stimulation of sensory neurons induces IGF-I production by releasing calcitonin gene-related peptide (CGRP) in the mouse brain, we hypothesized that donepezil increases IGF-I production by sensory neuron stimulation to improve the cognitive function in mice. Donepezil, but not tacrine, increased the CGRP release from dorsal root ganglion neurons isolated from wild-type (WT) mice. Pretreatment with the protein kinase A inhibitor KT5720 [(9S, 10S, 12R)-2,3,9,10,12-hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg: 3', 2', 1'-kl] pyrrolo[3,4-i][1,6]-benzo-diazocine-10-carboxylic acid hexyl ester] reversed the effects induced by donepezil. Increase in tissue levels of CGRP, IGF-I, and IGF-I mRNA in the hippocampus was observed at 4 weeks after oral administration of donepezil in WT mice. In these animals, c-fos expression in spinal dorsal horns, parabrachial nuclei, the solitary tract nucleus, and the hippocampus was increased. Enhancement in angiogenesis and neurogenesis was observed in the dentate gyrus of the hippocampus of WT mice after donepezil administration. Improvement of spatial learning was observed in WT mice after donepezil administration. Oral administration of tacrine for 4 weeks produced none of the aforementioned effects induced by donepezil in WT mice. However, none of the effects observed in WT mice was seen after donepezil administration in CGRP-knockout mice and WT mice subjected to functional denervation. These observations suggest that donepezil may improve cognitive function in mice by increasing the hippocampal production of IGF-I through sensory neuron stimulation. These effects of donepezil may not be dependent on its acetylcholinesterase inhibitory activity.
  • Continuous Positive Airway Pressure Applied Through a Bronchial Blocker as a Treatment for Hypoxemia due to stenosis of the Left Main Bronchus, Hiroshi Sasano, Nobuko Sasano, Shoji Ito, Yoshihito Fujita, Takesi Sugiura, Masato Morita, Kazuya Sobue, ANESTHESIOLOGY, 110, (5) 1199 - 1200,   2009年05月, 査読有り
  • Skin-traction method prevents the collapse of the internal jugular vein caused by an ultrasound probe in real-time ultrasound-assisted guidance, Hiroshi Sasano, Masato Morita, Takafumi Azami, Shoji Ito, Nobuko Sasano, Rina Kato, Hiroyuki Hirate, Hiroaki Ito, Akinori Takeuchi, Kazuya Sobue, JOURNAL OF ANESTHESIA, 23, (1) 41 - 45,   2009年02月, 査読有り, Purpose. Real-time ultrasound-assisted guidance for catheterization of the internal jugular vein (IJV) is known to be useful, especially for a small-sized vein, which is difficult to catheterize. However, one of the problems with real-time ultrasound-assisted guidance is that the ultrasound probe itself can collapse the vein. We have developed a novel "skin-traction method (STM)", in which the puncture point of the skin over the IJV is stretched upwards with several pieces of surgical tape in the cephalad and caudal directions with the aim being to facilitate catheterization of the IJV. We examined whether this method increased the compressive force required to collapse the IJV. Methods. In ten volunteers, the compressive force required to collapse the right IJV, and the cross-sectional area and anteroposterior and transverse diameters of the IJV were measured with ultrasound imaging in the supine position (SP) with or without the STM or in the Trendelenburg position of 10 degrees head-down (TP) without the STM. Results. The compressive force to required to collapse the vein was increased significantly with the STM, while the cross-sectional area and anteroposterior diameter of the vein in the SP with STM were similar to those in the TP without the STM. Conclusion. With the STM, not only the cross-sectional area but also the compressive force required to collapse the IJV increased. Thus, the STM may facilitate real-time ultrasound-assisted guidance for catheterization of the IJV by maintaining the cross-sectional area of the vein during the guidance.
  • Before-after study of a restricted fluid infusion strategy for management of donor hepatectomy for living-donor liver transplantation, Yoshihito Fujita, Akinori Takeuchi, Takeshi Sugiura, Tomonori Hattori, Nobuko Sasano, Yuichiro Mizuochi, Kazuya Sobue, JOURNAL OF ANESTHESIA, 23, (1) 67 - 74,   2009年02月, 査読有り, Purpose. Intraoperative fluid infusion strategy remains controversial. Many animal model studies have shown that restricted fluid infusion reduces blood loss, though reports on this topic in humans are rare. The purpose of this study was to determine the effects on volume of blood loss of a restricted fluid infusion strategy for hepatectomy in donors for living-donor liver transplantation. Methods. A before-after study design was used with prospective consecutive data collection. A total of 22 patients who underwent living- donor hepatectomy were enrolled. Eleven patients who were managed before the implementation of restricted-volume fluid administration comprised the standard-volume group, and 11 who were evaluated after the implementation of the restricted-volume infusion strategy comprised the restricted-volume group. In the standard-volume group, the donors were given 10 ml.kg(-1).h(-1) of lactated Ringer's solution and additional plasma expander corresponding to blood loss. In the restricted-volume group, the donors received 5 ml.kg(-1.)h(-1) of lactated Ringer's solution until the resection of the hepatic graft, followed by 15 ml.kg(-1).h(-1) of lactated Ringer's solution after the completion of resection until the end of the operation. Results. Intraoperative blood loss was less in the restricted-volume group (445 +/- 193 ml) than in the standard-volume group (1331 +/- 602 ml; P < 0.01). Intraoperative fluid infusion was also less in the restricted-volume group (4130 +/- 563 ml) than in the standard-volume group (5634 +/- 1260 ml; P < 0.01). There were no differences in length of hospital stay or side effects between the two groups. Conclusion. Our restricted-volume strategy reduced blood loss and had no adverse effects during living- donor hepatectomy.
  • A simple, lightweight CPAP-delivery device, composed of a three-way stopcock, for the nondependent lung, Hiroshi Sasano, Nobuko Sasano, Shoji Ito, Takafumi Azami, Masato Morita, Akinori Takeuchi, Kazuya Sobue, JOURNAL OF ANESTHESIA, 23, (1) 93 - 98,   2009年02月, 査読有り, Purpose. We aimed to introduce a simple, lightweight continuous positive airway pressure (CPAP)-delivery device for the nondependent lung during one-lung ventilation, to investigate how the type of three-way stopcocks, and the compliance and resistance of a test lung affect the relationship between the oxygen flow rate and CPAP level produced, and to examine how the device works in a clinical setting. Methods. In the test lung study, the bronchial blocker of a Univent tube was connected to a test lung. The effects of oxygen-flow rate, types of three-way stopcocks, and compliance and resistance of the test lung on the CPAP levels were studied. In the clinical study, the lightweight device was used to treat hypoxia in seven patients during one-lung ventilation with the bronchial blocker. Results. In the test lung study, the CPAP level produced by the device was proportional to the oxygen-flow rate, dependent on the type of three-way stopcock used, and independent of the compliance or resistance of the test lung. There was no discrepancy between the plateau pressures of the test lung and the monitoring port of an additional stopcock at any degree of compliance or resistance of the test lung at any oxygen-flow rate. Therefore, the relationship between the oxygen-flow rate and CPAP level can be ensured in advance before application to the lung, with an additional three-way stopcock of which the distal end is occluded. In the clinical study, peripheral oxygen sataration (SpO(2)) improved while the CPAP level ranged from 2.8 to 5.4 cmH(2)O. Conclusion. The lightweight CPAP delivery-device can provide variable CPAP levels by adjusting the oxygen-flow rate without real-time monitoring of the pressure.
  • Localization of Reversion-Induced LIM Protein (RIL) in the Rat Central Nervous System, Yuko Iida, Toshiyuki Matsuzaki, Tetsuro Morishima, Hiroshi Sasano, Kiyofumi Asai, Kazuya Sobue, Kuniaki Takata, ACTA HISTOCHEMICA ET CYTOCHEMICA, 42, (1) 9 - 14,   2009年, 査読有り, Reversion-induced LIM protein (RIL) is a member of the ALP (actinin-associated LIM protein) subfamily of the PDZ/LIM protein family. RIL serves as an adaptor protein and seems to regulate cytoskeletons. Immunoblotting suggested that RIL is concentrated in the astrocytes in the central nervous system. We then examined the expression and localization of RIL in the rat central nervous system and compared it with that of water channel aquaporin 4 (AQP4). RIL was concentrated in the cells of ependyma lining the ventricles in the brain and the central canal in the spinal cord. In most parts of the central nervous system, RIL was expressed in the astrocytes that expressed AQP4. Double-labeling studies showed that RIL was concentrated in the cytoplasm of astrocytes where glial fibrillary acidic protein was enriched as well as in the AQP4-enriched regions such as the endfeet or glia limitans. RIL was also present in some neurons such as Purkinje cells in the cerebellum and some neurons in the brain stem. Differential expression of RIL suggests that it may be involved in the regulation of the central nervous system.
  • Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes., Morishima T, Aoyama M, Iida Y, Yamamoto N, Hirate H, Arima H, Fujita Y, Sasano H, Tsuda T, Katsuya H, Asai K, Sobue K, Neuroscience research, 61, (1) 18 - 26,   2008年05月, 査読有り
  • Anesthetic management of a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) during laparotomy, Nobuko Sasano, Yoshihito Fujita, Min Hye So, Kazuya Sobue, Hiroshi Sasano, Hirotada Katsuya, JOURNAL OF ANESTHESIA, 21, (1) 72 - 75,   2007年, 査読有り, A 53-year-old man with mitochondrial myopathy, encephalopathy. lactic acidosis, and stroke-like episodes (MELAS) underwent a gastrectomy. We administered bicarbonated Ringer's solution, which has a physiological concentration of bicarbonate. The level of serum lactate did not increase significantly, and metabolic acidosis did not occur throughout surgery or for 3h after surgery. Aggressive warming was needed to maintain normothermia, presumably because the mitochondrial respiratory chain, which is responsible for thermogenesis, is impaired in MELAS patients. It is important to maintain normothermia in MELAS patients in order to avoid further mitochondrial metabolic depression.
  • Cardiac output increases the rate of carbon monoxide elimination in hyperpneic but not normally ventilated dogs, Susumu Ishida, Akinori Takeuchi, Takafumi Azami, Kazuya Sobue, Hiroshi Sasano, Hirotada Katsuya, Joseph A. Fisher, JOURNAL OF ANESTHESIA, 21, (2) 181 - 186,   2007年, 査読有り, Purpose. The very high solubility of carbon monoxide (CO) in blood suggests that its elimination depends predominantly on ventilation and not perfusion. Nevertheless, hyperventilation is not used for CO elimination because of the adverse effects of hypocapnia. With isocapnic hyperpnea (IH), ventilation can be increased considerably without hypocapnia. This raises the issue of whether CO elimination is limited by perfusion during IH. We studied the effect of increasing cardiac output on t(1/2), the half-time of decline of blood carboxyhemoglobin concentration ([COHb]), during normal ventilation (NV) and during IH. Methods. After ethics approval was received, 13 pentobarbital -anesthetized ventilated dogs were exposed to CO to increase their [COHb]. They were then ventilated with NV or IH. At each level of ventilation, dogs were randomly assigned to treatment with dobutamine (to increase cardiac output) or to no dobutamine treatment. After the return of [COHb] to control levels, each dog was re-exposed to CO and treated with the same ventilatory mode, but the alternative inotropic treatment. Results. Gas exchange, [COHb], and hemodynamic measures were recorded during the study. Cardiac index values in the IH group were 4.1 +/- 0.5 and 8.2 +/- 1.21.min(-1).m(-2) without and with dobutamine infusion, respectively. Dobutamine infusion was associated with a reduction in t(1/2) from 20.3 +/- 3.6 to 16.9 +/- 2.4 min (P = 0.005) in the IH group, but no change in the NV group. Conclusion. These findings suggest that CO elimination during IH treatment is limited at least partly by pulmonary blood flow and may therefore be further augmented by increasing cardiac output.
  • Circulatory collapse caused by unnoticed hypermagnesemia in a hospitalized patient, Minhye So, Hiroaki Ito, Kazuya Sobue, Takako Tsuda, Hirotada Katsuya, JOURNAL OF ANESTHESIA, 21, (2) 273 - 276,   2007年, 査読有り, We report a case of hypermagnesemia in a hospitalized patient after prolonged laxative use; due to preexisting impaired consciousness and digestive problems, the hypermagnesemia was difficult to detect until it almost became fatal. A 64-year-old man who was a patient at another hospital for treatment of head injury and gastric ulcer had developed circulatory collapse and was transferred to our hospital. Hypermagnesemia (serum magnesium concentration 11.0 mg.dl(-1)) was thought to be the cause of the circulatory collapse and treatments were successful. A magnesium laxative had been administered for more than a month at the previous hospital, but the patient's serum magnesium level was never measured. Care should be taken when a magnesium laxative is administered to patients who already have impaired consciousness and digestive problems that are early symptoms of hypermagnesemia.
  • Intra-operative monitoring of vagal nerve activity with wire electrodes, H. Ito, K. Sobue, M. So, H. Hirate, T. Sugiura, T. Azami, Y. Fujita, H. Sasano, H. Katsuya, ACTA ANAESTHESIOLOGICA SCANDINAVICA, 50, (10) 1304 - 1305,   2006年11月, 査読有り, A monitoring system for tracking the electromyogram (EMG) of the vocal cords with wire electrodes embedded in an enclotracheal tube was designed to identify the recurrent laryngeal nerve during thyroidectomy. Our recent experience in two cases suggests that vagal nerve activity can be correctly detected by recording of the EMG of the vocal cords using a special endotracheal tube embedded with wire electrodes.
  • Interleukin-1 beta induces the expression of aquaporin-4 through a nuclear factor-kappa B pathway in rat astrocytes, Hiroaki Ito, Naoki Yamamoto, Hajime Arima, Hiroyuki Hirate, Tetsuro Morishima, Fuminori Umenishi, Toyohiro Tada, Kiyofumi Asai, Hirotada Katsuya, Kazuya Sobue, JOURNAL OF NEUROCHEMISTRY, 99, (1) 107 - 118,   2006年10月, 査読有り, Interleukin (IL)-1 beta is known to play a role in the formation of brain edema after various types of injury. Aquaporin (AQP)4 is also reported to be involved in the progression of brain edema. We tested the hypothesis that AQP4 is induced in response to IL-1 beta. We found that expression of AQP4 mRNA and protein was significantly up-regulated by IL-1 beta in cultured rat astrocytes, and that intracerebroventricular administration of IL-1 beta increased the expression of AQP4 protein in rat brain. The effects of IL-1 beta on induction of AQP4 were concentration and time dependent. The effects of IL-1 beta on AQP4 were mediated through IL-1 beta receptors because they were abolished by co-incubation with IL-1 receptor antagonist. It appeared that IL-1 beta increased the level of AQP4 mRNA without involvement of de novo protein synthesis because cycloheximide, a protein synthesis inhibitor, did not inhibit the effects of IL-1 beta. Inhibition of the nuclear factor-kappa B (NF-kappa B) pathway blocked the induction of AQP4 by IL-1 beta in a concentration-dependent manner. These findings show that IL-1 beta induces expression of AQP4 through a NF-kappa B pathway without involvement of de novo protein synthesis in rat astrocytes.
  • Use of ketamine to facilitate opioid withdrawal in a child., Ito H, Sobue K, Hirate H, Sugiura T, So M, Azami T, Sasano H, Katsuya H, Anesthesiology, 104, (5) ,   2006年05月, 査読有り
  • Postextubation airway management with nasal continuous positive airway pressure in a child with Down syndrome., Ito H, Sobue K, So MH, Sugiura T, Sasano H, Takeuchi A, Katsuya H, Journal of anesthesia, 20, (2) 106 - 108,   2006年, 査読有り
  • Inadvertent intrathecal cannulation in an infant, demonstrated by three-dimensional computed tomography: a rare complication of internal jugular vein catheterization., Fujita Y, Sobue K, Hattori T, Takeuchi A, Tsuda T, Katsuya H, Journal of anesthesia, 20, (2) 122 - 125,   2006年, 査読有り
  • Use of landiolol in the perioperative management of supraventricular tachycardia., Ito H, Sobue K, So M, Hirate H, Sugiura T, Azami T, Sasano H, Katsuya H, Journal of anesthesia, 20, (3) 253 - 254,   2006年, 査読有り
  • Flexible, tapered-tip tube facilitates conventional orotracheal intubation by novice intubators., So M, Sobue K, Arima H, Morishima T, Fukumoto M, Nakano H, Tsuda T, Katsuya H, Journal of anesthesia, 20, (4) 344 - 347,   2006年, 査読有り
  • The changes in pulmonary capillary blood flow and anatomical dead space during pulmonary resection under one-lung ventilation., Ito S, Sasano H, Sobue K, Azami T, Tsuda T, Katsuya H, Journal of clinical monitoring and computing, 19, (3) 215 - 217,   2005年06月, 査読有り
  • Anesthetic and airway management of general anesthesia in a patient with Meckel-Gruber syndrome., Miyazu M, Sobue K, Ito H, Azami T, Ito S, Takeuchi A, Sasano H, Tsuda T, Katsuya H, Journal of anesthesia, 19, (4) 309 - 310,   2005年, 査読有り
  • Sevoflurane for general anaesthetic management in a patient with Larsen syndrome, T Morishima, K Sobue, S Tanaka, MH So, H Arima, H Ando, H Katsuya, PAEDIATRIC ANAESTHESIA, 14, (2) 194 - 195,   2004年02月, 査読有り
  • Sensitive immunoassays for human and rat GMFB and GMFG, tissue distribution and age-related changes., Inagaki M, Aoyama M, Sobue K, Yamamoto N, Morishima T, Moriyama A, Katsuya H, Asai K, Biochimica et biophysica acta, 1670, (3) 208 - 216,   2004年02月, 査読有り
  • A case of complex regional pain syndrome type II after transradial coronary intervention., Sasano N, Tsuda T, Sasano H, Ito S, Sobue K, Katsuya H, Journal of anesthesia, 18, (4) 310 - 312,   2004年, 査読有り
  • Effect of mild hypothermia on the expression of aquaporin family in cultured rat astrocytes under hypoxic condition, Y Fujita, N Yamamoto, K Sobue, M Inagaki, H Ito, H Arima, T Morishima, A Takeuchi, T Tsuda, H Katsuya, K Asai, NEUROSCIENCE RESEARCH, 47, (4) 437 - 444,   2003年12月, 査読有り, Aquaporins (AQPs) are a family of water-selective transporting proteins with homology to the major intrinsic protein (MIP) of lens, that increase plasma membrane water permeability in secretory and absorptive cells. In this study, we investigated the effect of mild hypothermia on the expression of AQP4, AQP5 and AQP9 in rat astrocytes cultured under hypoxic conditions. At 37degreesC, a marked decrease in the expression of AQP4, AQP5 and AQP9 mRNAs was observed. However, at 32degreesC (mild hypothermia), the expression of AQP5 mRNA was restored to its basal level. Interestingly, under mild hypothermia AQP4 mRNA expression transiently decreased and then increased about two-fold; while AQP9 mRNA expression decreased the same as at 37degreesC. The changes in the expression of AQP4 and AQP9 proteins were confirmed by Western blot analysis. The restoration of the AQP4 and AQP5 expression at 32degreesC from the hypoxia-induced decrease at 37degreesC may play an important role in the reduction of brain edema under hypothermic conditions. (C) 2003 Elsevier Ireland Ltd and The Japan Neuroscience Society. All rights reserved.
  • Hyperosmolar mannitol stimulates expression of aquaporins 4 and 9 through a p38 mitogen-activated protein kinase-dependent pathway in rat astrocytes, H Arima, N Yamamoto, K Sobue, F Umenishi, T Tada, H Katsuya, K Asai, JOURNAL OF BIOLOGICAL CHEMISTRY, 278, (45) 44525 - 44534,   2003年11月, 査読有り, The membrane pore proteins, aquaporins (AQPs), facilitate the osmotically driven passage of water and, in some instances, small solutes. Under hyperosmotic conditions, the expression of some AQPs changes, and some studies have shown that the expression of AQP1 and AQP5 is regulated by MAPKs. However, the mechanisms regulating the expression of AQP4 and AQP9 induced by hyperosmotic stress are poorly understood. In this study, we observed that hyperosmotic stress induced by mannitol increased the expression of AQP4 and AQP9 in cultured rat astrocytes, and intraperitoneal infusion of mannitol increased AQP4 and AQP9 in the rat brain cortex. In addition, a p38 MAPK inhibitor, but not ERK and JNK inhibitors, suppressed their expression in cultured astrocytes. AQPs play important roles in maintaining brain homeostasis. The expression of AQP4 and AQP9 in astrocytes changes after brain ischemia or traumatic injury, and some studies have shown that p38 MAPK in astrocytes is activated under similar conditions. Since mannitol is commonly used to reduce brain edema, understanding the regulation of AQPs and p38 MAPK in astrocytes under hyperosmotic conditions induced with mannitol may lead to a control of water movements and a new treatment for brain edema.
  • Aspiration pneumonia associated with a giant epiglottic cyst after cardiac surgery, M So, K Sobue, H Arima, T Morishima, M Fukumoto, S Tanaka, H Ando, H Katsuya, CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 50, (6) 622 - 623,   2003年06月, 査読有り
  • Difficult airway in a child with spinal muscular atrophy type I, H Arima, K Sobue, S Tanaka, T Morishima, H Ando, H Katsuya, PAEDIATRIC ANAESTHESIA, 13, (4) 342 - 344,   2003年05月, 査読有り, Spinal muscular atrophy (SMA) type I is a relatively common inherited neuromuscular disease of hypotonic newborns, but is not associated with craniofacial abnormalities. There is nothing in the literature about difficult intubation in patients affected by this disease. We report a case of 34-month-old girl with SMA type I who was scheduled for emergency endoscopic laser treatment of tracheal stenosis caused by granulations. Tracheostomy was performed at 17 months of age and before this, the orotracheal tube was changed periodically without difficulty. For this laser treatment, orotracheal intubation was required. Preoperative physical examination revealed micrognathia and class II malocclusion. Opening her mouth was not difficult. Although difficult orotracheal intubation was predictable, we attempted to intubate her trachea as usual, but could not visualize the epiglottis. We decided to proceed with retrograde intubation, one of the standard techniques employed in a child with a difficult airway, via the tracheostome. A feeding nasogastric catheter was used as a guide catheter, and our strategy was successful. In this study we report a case of difficult airway in a child with SMA type I. The relationship between SMA type I with a tracheostome and difficult airway are discussed.
  • Profound pain due to propofol injection triggered myocardial ischemia in a patient with a suspected pheochromocytoma., Morishima T, Sobue K, Arima H, Tanaka S, So M, Ando H, Katsuya H, Anesthesia and analgesia, 96, (2) ,   2003年02月, 査読有り
  • Skin analgesia with lidocaine tape prior to epidural blockade, K Sobue, T Tsuda, M Yumoto, T Nakagawa, M Nakano, H Katsuya, CANADIAN JOURNAL OF ANAESTHESIA-JOURNAL CANADIEN D ANESTHESIE, 50, (1) 95 - 96,   2003年01月, 査読有り
  • Transient and reversible parkinsonism after acute organophosphate poisoning., Arima H, Sobue K, So M, Morishima T, Ando H, Katsuya H, Journal of toxicology. Clinical toxicology, 41, (1) 67 - 70,   2003年, 査読有り
  • Airway obstruction associated with transesophageal echocardiography in a patient with a giant aortic pseudoaneurysm., Arima H, Sobue K, Tanaka S, Morishima T, Ando H, Katsuya H, Anesthesia and analgesia, 95, (3) 558 - 60, table of contents,   2002年09月, 査読有り
  • Profound sinus bradycardia after intravenous nicardipine., Arima H, Sobue K, Tanaka S, Morishima T, Ando H, Katsuya H, Anesthesia and analgesia, 95, (1) 53 - 5, table of contents,   2002年07月, 査読有り
  • Differential regulation of aquaporin-5 and-9 expression in astrocytes by protein kinase A, N Yamamoto, K Sobue, M Fujita, H Katsuya, K Asai, MOLECULAR BRAIN RESEARCH, 104, (1) 96 - 102,   2002年07月, 査読有り, Aquaporins (AQPs) transport water through the membranes of numerous tissues, but the molecular mechanisms for regulating water balance in brain are unknown. In this study, we investigated the effects of a protein kinase A (PKA) activator on the expression of AQP4, 5 and 9 in cultured rat astrocytes. Treatment of the cells with dbcAMP caused decreases in AQP5 mRNA and protein and increases in AQP9 mRNA and protein in time- and concentration-dependent manners. However, AQP4 mRNA and protein were not changed by treatment with dbcAMP. The dbcAMP-induced effects on AQP5 and AQP9 mRNAs were inhibited by PKA inhibitors. In addition, pretreating the cells with an inhibitor of protein synthesis, cycloheximide, inhibited the increase in AQP9 mRNA induced by dbcAMP, but not the decrease in AQP5 mRNA. These results suggest that signal transduction via PKA may play important. roles in regulating the expression of AQP5 and AQP9, and the effect on AQP9 may be mediated by some factors induced by dbcAMP. (C) 2002 Elsevier Science B.V. All rights reserved.
  • Nitric oxide inhalation is useful in the management of right ventricular failure caused by myocardial infarction, Y Fujita, O Nishida, K Sobue, H Ito, N Kusama, M Inagaki, H Katsuya, CRITICAL CARE MEDICINE, 30, (6) 1379 - 1381,   2002年06月, 査読有り, Objective: To describe hemodynamic improvement in a patient treated with nitric oxide (NO) inhalation in the management of right ventricular failure caused by myocardial infarction. Design: Case report. Setting: An intensive care unit of a university hospital. Patient: A 66-yr-old man with severe right ventricular failure caused by acute myocardial infarction. Interventions. Nitric oxide inhalation through a ventilator circuit. Measurements and Main Results: The patient complained of chest pain. When myocardial infarction was diagnosed, he underwent percutaneous transluminal coronary angioplasty and percutaneous transluminal coronary recanalization, but they were not effective. We instituted intra-aortic balloon pumping and brought the patient to the intensive care unit (ICU). Even with high-dose inotropic support, his hemodynamics deteriorated gradually. On the patient's seventh day in the ICU, we started NO inhalation at 5-10 ppm in an attempt to relieve his right heart failure. Immediately after NO inhalation was started, his hemodynamics improved significantly, and we could wean the patient from intra-aortic balloon pumping. NO inhalation was continued for 9 days and was successfully discontinued without circulatory deterioration. He was discharged from our hospital uneventfully. Conclusion: Nitric oxide inhalation improved hemodynamics in our patient with right ventricular failure after myocardial infarction. Our report suggests that a clinical trial of NO treatment for severe right ventricular failure caused by myocardial infarction is warranted.
  • Glycogen synthase kinase-3,beta is complexed with tau protein in brain microtubules, W Sun, HY Qureshi, PW Cafferty, K Sobue, A Agarwal-Mawal, KD Neufield, HK Paudel, JOURNAL OF BIOLOGICAL CHEMISTRY, 277, (14) 11933 - 11940,   2002年04月, 査読有り, In Alzheimer's disease, microtubule-associated protein tau is hyperphosphorylated by an unknown mechanism and is aggregated into paired helical filaments. Hyperphosphorylation causes loss of tau function, microtubule instability, and neurodegeneration. Glycogen synthase kinase-3beta (GSK3beta) has been implicated in the phosphorylation of tau in normal and Alzheimer's disease brain. The molecular mechanism of GSK3beta-tau interaction has not been clarified. In this study, we find that when microtubules are disassembled, microtubule-associated GSK3beta dissociates from microtubules. From a gel filtration column, the dissociated GSK3beta elutes as an similar to400-kDa complex. When fractions containing the similar to400-kDa complex are chromatographed through an anti-GSK3beta immunoaffinity column, tau co-elutes with GSK3beta. From fractions containing the similar to400-kDa complex, both tau and GSK3beta co-immunoprecipitate with each other. GSK3beta binds to nonphosphorylated tau, and the GSK3beta-binding region is located within the N-terminal projection domain of tau. In vitro, GSK3beta associates with microtubules only in the presence of tau. From brain extract, similar to6-fold more GSK3beta co-immunoprecipitates with tau than GSK3alpha. These data indicate that, in brain, GSK3beta is bound to tau within a similar to400-kDa microtubule-associated complex, and GSK3beta associates with microtubules via tau.
  • Regulation of aquaporin-4 expression in astrocytes., Yoneda K, Yamamoto N, Asai K, Sobue K, Fujita Y, Fujita M, Mase M, Yamada K, Nakanishi M, Tada T, Miura Y, Kato T, Brain Res Mol Brain Res., 89, (1-2) 94 - 102,   2001年, 査読有り
  • Alterations in the expression of the AQP family in cultured rat astrocytes during hypoxia and reoxygenation., Yamamoto N, Yoneda K, Asai K, Sobue K, Tada T, Fujita Y, Katsuya H, Fujita M, Aihara N, Mase M, Yamada K, Miura Y, Kato T, Brain Res Mol Brain Res., 90, (1) 26 - 38,   2001年, 査読有り
  • Differential regulation of aquaporin expression in astrocytes by protein kinase C., Yamamoto N, Sobue K, Miyachi T, Inagaki M, Miura Y, Katsuya H, Asai K, Brain Res Mol Brain Res., 95, (1-2) 110 - 106,   2001年, 査読有り
  • Molecular cloning of two bovine aquaporin-4 cDNA isoforms and their expression in brain endothelial cells, K Sobue, N Yamamoto, K Yoneda, K Fujita, Y Miura, K Asai, T Tsuda, H Katsuya, T Kato, BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1489, (2-3) 393 - 398,   1999年12月, 査読有り, Two cDNA isoforms of bovine aquaporin-4 (bAQP4-A and bAQP4-B) were newly isolated. Sequence analysis of both cDNAs revealed open reading frames of 972 (bAQP4-A) and 906 nucleotides (bAQP4-B) with deduced proteins of 323 (bAQP4-A) and 301 amino acid residues (bAQP4-B). Partial 5'-genomic sequence analysis showed that the 5'-noncoding sequences specific to bAQP4-A and -B transcripts were contained in distinct exons, exon 0 for bAQP4-A and new exon X for bAQP4-B. RNase protection assay demonstrated the definite expression of both isoforms in bovine brain. The deduced amino acid sequence of bAQP4-A was highly homologous to the human (97%), rat (95%), and mouse (93%) AQP4. Reverse transcription-PCR detected the expression of AQP4 mRNAs in bovine brain endothelial cells as well as in a variety of bovine organs such as brain, lung, spleen, and kidney. Northern blot analysis indicated that a 6.0 kb message is predominantly expressed in bovine brain and lung. (C) 1999 Elsevier Science B.V. All rights reserved.
  • Induction of blood-brain barrier properties in immortalized bovine brain endothelial cells by astrocytic factors, K Sobue, N Yamamoto, K Yoneda, ME Hodgson, K Yamashiro, N Tsuruoka, T Tsuda, H Katsuya, Y Miura, K Asai, T Kato, NEUROSCIENCE RESEARCH, 35, (2) 155 - 164,   1999年11月, 査読有り, The blood-brain barrier (B-BB) protects the free passage of substances into the brain and maintains the homeostasis of the central nervous system. It is commonly accepted that astrocytes surrounding brain endothelial cells influence the B-BB formation and the exhibition of B-BB function of capillaries. To begin the in vitro study on the B-BB, it is essential to obtain a homogenous and sufficient supply of brain endothelial cells as well as astrocytes. We thus immortalized the bovine brain endothelial cell (BBEC) by transfection of the SV40 large T antigen and obtained a single clone, t-BBEC-117, which retained the brain endothelial cell phenotype. Astrocyte in co-culture was found to tighten the intercellular contacts of the immortal cells resulting in a reduced L-glucose permeability, and its conditioned medium (CM) augmented a B-HB phenotype, alkaline phosphatase (ALP) activity. Among known astrocytic factors, only fibroblast growth factor-basic (bFGF) could mimic the actions of astrocytes as measured by L-glucose permeability and ALP activity. Moreover, anti-bFGF antibody canceled 90% of ALP activation by astrocyte CM. Basic FGF, however, failed to induce other B-BB phenotypes such as the expressions of multidrug resistance (mdr) and glucose transporter (GLUT-1) genes. These data suggest that bFGF is one of the most plausible astrocytic factors to induce the B-BB properties of immortal brain endothelial cells together with some unknown factors in the astrocyte CM. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
  • Experimental implication of celiac ganglionotropic invasion of pancreatic-cancer cells bearing c-ret proto-oncogene with reference to glial-cell-line-derived neurotrophic factor (GDNF)., Okada Y, Takeyama H, Sato M, Morikawa M, Sobue K, Asai K, Tada T, Kato T, Manabe T, Int J Cancer., 81, (1) 67 - 73,   1999年, 査読有り
  • Astrocytic gap junction blockage and neuronal Ca2+ oscillation in neuron-astrocyte cocultures in vitro, K Fujita, K Nakanishi, K Sobue, T Ueki, K Asai, T Kato, NEUROCHEMISTRY INTERNATIONAL, 33, (1) 41 - 49,   1998年07月, 査読有り, We have investigated the effects of gap junction inhibitors, octanol, halothane, sodium propionate and lindane, on neuronal periodic Ca2+ transients in neuron-astrocyte coculture systems. Octanol reduced the amplitude and frequency of Ca2+ oscillations in dose-dependent manner. One mM octanol caused a complete disappearance of Ca2+ oscillations. Similar suppressions were obtained by halothane (1 mM) and sodium propionate (25 mM). In contrast, lindane (300 nM) uniquely raised the basal level of [Ca2+](i) in oscillating neurons as well as the height of apparent amplitude without changes in the frequency. The current results imply that octanol, halothane and sodium propionate might lower the frequency of spontaneous Ca2+ oscillations by blocking the gap junctional communication of neighboring astrocytes and that lindane, though also blocking the gap junctions, might not affect the frequency but reversely increase both the basal [Ca2+](i) and the amplitude, probably due to an increase of neuronal [Ins (1.4.5)P-3](i). These findings strongly suggest that astrocytes contribute to the generation of periodic neuronal Ca2+ oscillations through astrocytic gap junctional communications and/or other signaling components between astrocytes and neurons. (C) 1998 Elsevier Science Ltd. All rights reserved.

MISC

  • 深部静脈血栓症の手術前スクリーニング~周術期の肺血栓塞栓症を防ぐために~, 関谷憲晃, 藤掛数馬, 松山周平, 伊藤遥, 太田一志, 長沼愛友, 祖父江和哉, 臨床麻酔, 43, (3) 489 - 494,   2019年
  • 超音波ガイド下硬膜外・脊髄くも膜下麻酔の実際, 草間宣好, 笹野寛, 祖父江和哉, 産科と婦人科, 5, (73) 599 - 603,   2019年
  • 日本でも実現するPACU 術後ケアを充実させるPACUのすがた, 川津文子, 祖父江和哉, LiSA, 26, (3) 250 - 254,   2019年
  • 麻薬中の誤薬・誤投与防止対策~最近の動向~, 志田恭子, 祖父江和哉, 臨床麻酔, 43, (3) 435 - 442,   2019年
  • これからの術中輸液・輸血管理 周術期の凝固系管理の今後を考える, 佐野 文昭, 仙頭 佳起, 平手 博之, 祖父江 和哉, 日本臨床麻酔学会誌, 38, (4) 504 - 510,   2018年07月
  • 【術前内服薬はそれでいいのか?-止めてはいけない理由,続けてはいけない理由を知る】 周術期薬品管理の原則-それぞれの職能を生かした多職種チームのちからで完璧に制御せよ, 仙頭 佳起, 祖父江 和哉, LiSA, 25, (6) 644 - 647,   2018年06月
  • 【麻酔科医は術前にどこを確認?安全な麻酔に生かす機器・器具のチェックポイント】 酸素ボンベ, 上村 友二, 祖父江 和哉, オペナーシング, 33, (5) 504 - 504,   2018年05月
  • 【麻酔科医は術前にどこを確認?安全な麻酔に生かす機器・器具のチェックポイント】 酸素配管装置, 上村 友二, 祖父江 和哉, オペナーシング, 33, (5) 505 - 505,   2018年05月
  • 【麻酔科医は術前にどこを確認?安全な麻酔に生かす機器・器具のチェックポイント】 亜酸化窒素遮断機構&アラーム, 上村 友二, 祖父江 和哉, オペナーシング, 33, (5) 506 - 506,   2018年05月
  • 【麻酔科医は術前にどこを確認?安全な麻酔に生かす機器・器具のチェックポイント】 気化器, 上村 友二, 祖父江 和哉, オペナーシング, 33, (5) 507 - 507,   2018年05月
  • 【チーム医療による手術侵襲軽減策とアウトカム】 患者満足度の向上に果たす周術期管理チームの役割 術後悪心嘔吐の観点から, 仙頭 佳起, 星加 麻衣子, 祖父江 和哉, 外科と代謝・栄養, 52, (2) 117 - 123,   2018年04月
  • 【術後認知機能障害】 Pros & Cons 本当に認知機能は低下するのか? 「低下する」とする立場から, 祖父江 和哉, LiSA, 25, (1) 52 - 55,   2018年01月
  • 【ICUにおける感染性合併症】 尿路感染症 その診断で間違いないですか?, 井上 雅史, 宮津 光範, 祖父江 和哉, LiSA, 24, (12) 1144 - 1147,   2017年12月
  • 【「重症患者における栄養管理」】 免疫栄養素投与の是非, 吉村 真一朗, 祖父江 和哉, 外科と代謝・栄養, 51, (6) 347 - 354,   2017年12月
  • 麻酔科医が行う周術期栄養管理は患者の予後改善に貢献できるのか 術中栄養投与は必要か, 吉村 真一朗, 祖父江 和哉, 日本臨床麻酔学会誌, 37, (7) 790 - 796,   2017年11月
  • エリスロポエチン派生物質による脳の修復と保護, 加古 英介, 金子 奈穂子, 祖父江 和哉, 澤本 和延, Nagoya Medical Journal, 55, (3) 129 - 135,   2017年06月
  • 【ICUにおける乳幼児の呼吸管理】 乳幼児呼吸管理中の鎮痛・鎮静 鎮痛・鎮静ガイドラインから, 上村 友二, 宮津 光範, 祖父江 和哉, ICUとCCU, 41, (3) 177 - 186,   2017年03月
  • 術後の飲水および食事の開始時期について, 寺島 良幸, 祖父江 和哉, 三浦 倫一, 大嶽 浩司, 臨床麻酔, 41, (2) 189 - 192,   2017年02月
  • 新バーコードを利用した手術室における誤薬・誤投与防止システム (トレーサビリティ特集号) -- (トレーサビリティへの取り組み), 志田 恭子, 播磨 恵, 祖父江 和哉, 製剤機械技術学会誌, 26, (5) 502 - 504,   2017年
  • 【麻酔関連機器の現況と課題】 麻酔器の人工呼吸器の現状 麻酔中の人工呼吸モードのあり方, 小笠原 治, 祖父江 和哉, 医療機器学, 86, (6) 537 - 542,   2016年12月
  • 【小児の呼吸管理-その常識は正しいか?-】 小児にカフ付き気管チューブを使っても合併症は増えないか?, 上村 友二, 宮津 光範, 祖父江 和哉, 救急・集中治療, 28, (9-10) 665 - 670,   2016年09月
  • 術後の重篤な有害事象(SAEs)に対する現状と対策 セーフティネットとしてのRapid Response System(RRS)の可能性 Rapid Response Systemによる術後患者の安全性向上, 仙頭 佳起, 藤谷 茂樹, 安宅 一晃, 祖父江 和哉, 日本臨床麻酔学会誌, 36, (1) 30 - 34,   2016年01月
  • 【神経精神疾患と麻酔】 Alzheimer病 麻酔による症状悪化の可能性を認識しつつ安定した麻酔管理を, 祖父江 和哉, LiSA, 22, (12) 1224 - 1226,   2015年12月
  • 【せん妄を考える】 術後の高次脳機能障害における麻酔の影響, 祖父江 和哉, 田村 哲也, 山本 直樹, 臨床麻酔, 39, (12) 1655 - 1660,   2015年12月
  • 脳に内在する再生メカニズム, 藤掛 数馬, 太田 晴子, 祖父江 和哉, 澤本 和延, 麻酔, 64, (増刊) S185 - S192,   2015年11月
  • 【病態ごとの輸液管理-その常識は正しいか?-】 肝不全患者の輸液管理 その常識は正しいか? 劇症肝炎を含む, 寺島 良幸, 宮津 光範, 祖父江 和哉, 救急・集中治療, 27, (9-10) 755 - 760,   2015年10月
  • 【Pressure】 忘れていないか 腹部コンパートメント症候群 見逃すと増悪しやすい危険な病態, 河野 真人, 祖父江 和哉, LiSA, 22, (8) 782 - 786,   2015年08月
  • 重症度スコア(APACHE)IIと比較した予後指標としての血中乳酸値の臨床的有用性 レトロスペクティブ、観察的コホート研究(Clinical usefulness of blood lactate level as a prognostic indicator comparing with Acute Physiology and Chronic health Evaluation(APACHE) II scores: A retrospective, observational, cohort stud, 藤田 義人, 加藤 妙, 山内 浩揮, 加古 英介, 徐 民恵, 田村 哲也, 祖父江 和哉, Nagoya Medical Journal, 54, (3) 89 - 99,   2015年05月
  • 誤薬・誤投与防止と麻酔記録の正確性の向上を両立した世界初のシステムNOS-SA(Nagoya City University Operation Room Safety-Smart Assistance)の開発と導入, 志田 恭子, 徐 民恵, 伊藤 秀和, 草間 宣好, 杉浦 健之, 祖父江 和哉, 臨床麻酔, 39, (3) 517 - 520,   2015年03月
  • 【よくあるトラブルを乗り越えよう1】 待てない手術患者がインフルエンザに感染していた 麻酔計画はもちろん,感染拡大防止策も忘れずに, 上村 友二, 宮津 光範, 祖父江 和哉, LiSA, 22, (2) 158 - 160,   2015年02月
  • 「チームで取り組む周術期の感染対策」によせて, 祖父江 和哉, 廣瀬 宗孝, 日本臨床麻酔学会誌, 35, (1) 48 - 48,   2015年
  • 【術後高次脳機能障害】 麻酔薬の高次脳機能への影響 基礎研究から見えるもの, 祖父江 和哉, 野手 英明, 徐 民恵, 麻酔, 63, (11) 1196 - 1201,   2014年11月
  • 【研修医の素朴な疑問に答えます 生理メカニズム】 尿量の低下は腎機能低下を意味するか, 吉澤 佐也, 祖父江 和哉, LiSA, 21, (10) 974 - 976,   2014年10月
  • 【研修医の素朴な疑問に答えます 病態生理を中心に】 尿が出ていれば腎不全にならないのか 腎臓の働きを理解しよう, 伊藤 秀和, 祖父江 和哉, LiSA, 21, (9) 844 - 846,   2014年09月
  • 【手術室での安全対策】 麻酔中の誤薬・誤投与防止対策, 志田 恭子, 祖父江 和哉, 臨床麻酔, 38, (9) 1276 - 1283,   2014年09月
  • 【手術室での安全対策】 PACU(Postanesthesia Care Unit)の現状と展望, 仙頭 佳起, 祖父江 和哉, 臨床麻酔, 38, (9) 1284 - 1291,   2014年09月
  • 【GS1データバーへの完全移行に向けて 医療用医薬品のバーコード活用マニュアル】 (第3章)医療機関での活用事例 セーフラベルシステム導入による手術室での薬効別カラーラベルの使用, 志田 恭子, 祖父江 和哉, 薬事, 56, (11) 1687 - 1691,   2014年09月
  • 【研修医の素朴な疑問に答えます 薬あれこれ】 ドパミンによる尿量増加のメカニズムとは, 吉澤 佐也, 祖父江 和哉, LiSA, 21, (8) 752 - 753,   2014年08月
  • 【麻酔と脳障害】 高齢者の脳に対する麻酔薬の影響, 祖父江 和哉, 山本 直樹, 医学のあゆみ, 249, (12) 1249 - 1253,   2014年06月
  • 【救急処置のトラブルとリカバリー】 超音波ガイド下中心静脈カテーテル挿入, 笹野 寛, 増田 和彦, 祖父江 和哉, 救急医学, 38, (6) 674 - 678,   2014年06月
  • 【感染症診療のポイント】 その他 Intravenous immunoglobulinの使い方, 西澤 義之, 宮津 光範, 祖父江 和哉, 救急医学, 38, (2) 233 - 235,   2014年02月
  • 「麻酔科医も明日からかかわる周術期栄養療法─現状の整理とこれからできること─」によせて, 祖父江 和哉, 日本臨床麻酔学会誌, 34, (3) 345 - 345,   2014年
  • 【未来への麻酔科学教育】 私の臨床教育法 名古屋市立大学の場合 学生指導には教員の指導環境も大切, 徐 民恵, 祖父江 和哉, LiSA, 20, (12) 1184 - 1187,   2013年12月
  • 【神経集中治療】 脳神経管理、モニタリング 脳浮腫と頭蓋内圧亢進, 田村 哲也, 祖父江 和哉, 救急医学, 37, (12) 1586 - 1590,   2013年11月
  • 実験講座 培養脳スライスを用いた新生ニューロンのライブイメージング, 藤掛 数馬, 匹田 貴夫, 祖父江 和哉, 澤本 和延, Surgery Frontier, 20, (3) 333 - 337,   2013年09月
  • 脳梗塞後の修復メカニズムと細胞治療 脳修復過程における内在性神経前駆細胞の移動, 藤掛 数馬, 匹田 貴夫, 祖父江 和哉, 澤本 和延, 脳循環代謝, 24, (Suppl.) 102 - 106,   2013年08月
  • 手術室の災害対策 手術室スタッフに対する教育を中心に, 笹野 寛, 有馬 一, 藤田 義人, 伊藤 彰師, 祖父江 和哉, 日本臨床麻酔学会誌, 33, (4) 545 - 549,   2013年07月
  • ホエイプロテイン/ホエイペプチド, 吉村 真一朗, 祖父江 和哉, 栄養-評価と治療, 30, (2) 135 - 137,   2013年05月
  • 【エキスパートが本気で教える重症患者の栄養管理-知らないと痛い目をみる!?コツとピットフォール-】 病態別栄養管理 心不全の栄養管理 より厳密な栄養管理で心不全の治療にも差をつけよう!, 仙頭 佳起, 幸村 英文, 祖父江 和哉, 急性・重症患者ケア, 2, (2) 392 - 398,   2013年05月
  • 【感染を防ぐ】 手指衛生とSSI予防 手術室で麻酔科医が行う医療関連感染症対策, 宮津 光範, 祖父江 和哉, LiSA, 20, (5) 432 - 437,   2013年05月
  • 麻酔科医に必要な超音波ガイド手技のポイントと教育(第1回) 超音波ガイド下血管穿刺 超音波ガイド下血管穿刺の合併症と環境整備, 笹野 寛, 森田 正人, 藤田 義人, 祖父江 和哉, 日本臨床麻酔学会誌, 33, (3) 470 - 475,   2013年05月
  • PICUとは何か? PICUと麻酔科医, 宮津 光範, 祖父江 和哉, 植田 育也, 臨床麻酔, 37, (4) 667 - 672,   2013年04月
  • 名古屋市立大学病院におけるNST活動の紹介, 伊藤 明美, 祖父江 和哉, 小川 了, 嘉村 由美子, 太田 美穂, 竹山 廣光, 新実 彰男, 日本臨床栄養学会雑誌, 35, (1) 65 - 67,   2013年03月
  • 【脳神経外科緊急手術】 頭部外傷患者の緊急手術 系統的な初期診療でPTDをなくし,周術期も外傷診療の一部であることを念頭におく, 吉村 真一朗, 祖父江 和哉, LiSA, 20, (2) 164 - 168,   2013年02月

講演・口頭発表等

  • 日本小児麻酔学会第25回大会, 松山周平, 仙頭佳起, 長谷川達也, 辻達也, 草間宣好, 田中基, 祖父江和哉, 日本小児麻酔学会第25回大会,   2019年
  • 第123回日本産科麻酔学会学術集会, 永井梓, 上村友二, 衣笠梨絵, 加古英介, 祖父江和哉, 田中基, 第123回日本産科麻酔学会学術集会,   2019年
  • 日本臨床麻酔学会第39回大会, 辻達也, 徐民恵, 永井梓, 衣笠梨絵, 上村友二, 草間宣好, 田中基, 祖父江和哉, 日本臨床麻酔学会第39回大会,   2019年
  • 日本麻酔科学会東海・北陸支部第17回学術集会, 小林亜里子, 草間宣好, 猪島まり, 永井梓, 藤掛数馬, 祖父江和哉, 日本麻酔科学会東海・北陸支部第17回学術集会,   2019年
  • 第41回日本手術医学会総会, 仙頭佳起, 大崎真理, 吉谷千枝, 神谷美樹, 日比佳子, 祖父江和哉, 第41回日本手術医学会総会,   2019年
  • 日本ペインクリニック学会第53回大会, 草間宣好, 杉浦健之, 藤掛数馬, 加藤利奈, 井口広靖, 徐民恵, 薊隆文, 祖父江和哉, 日本ペインクリニック学会第53回大会,   2019年
  • 日本集中治療医学会第3回東海北陸支部学術集会, 仙頭佳起, 祖父江和哉, 日本集中治療医学会第3回東海北陸支部学術集会,   2019年
  • 東京麻酔専門医会リフレッシャーコースセミナー, 祖父江和哉, 東京麻酔専門医会リフレッシャーコースセミナー,   2019年
  • 第9回かがわ輸液療法ベーシックセミナー, 祖父江和哉, 第9回かがわ輸液療法ベーシックセミナー,   2019年
  • 日本麻酔科学会第66回学術集会, 太田一志, 仙頭佳起, 徐民恵, 関谷憲晃, 大佐賀智, 祖父江和哉, 日本麻酔科学会第66回学術集会,   2019年
  • 東海・北陸ペインクリニック学会第30回東海地方会, 加藤利奈, 杉浦健之, 草間宣好, 徐民恵, 加古英介, 太田晴子, 井口広靖, 藤掛数馬, 薊隆文, 祖父江和哉, 東海・北陸ペインクリニック学会第30回東海地方会,   2019年
  • PKAおよびPKC経路とアストロサイトのネプリライシンとインスリン分解酵素発現検討, 山本 直樹, 祖父江 和哉, Dementia Japan,   2018年09月
  • 術前と術後をつなぐ手術部看護師による周術期ケア【活動報告】, 可知井京香, 大崎真理, 吉谷千枝, 神谷美樹, 守田結衣, 日比佳子, 仙頭佳起, 祖父江和哉, 第40回日本手術医学会総会,   2018年09月
  • 術後の患者調節鎮痛法に関する患者理解度の調査(第2報), 榊原諒子, 仙頭佳起, 羽藤実真, 祖父江和哉, 第40回日本手術医学会総会,   2018年09月
  • ユースタキ弁遺残により右房内血流障害を来たした心房中隔欠損修復術の一例, 衣笠梨絵, 加古英介, 仙頭佳起, 祖父江和哉, 第23回日本心臓血管麻酔学会学術大会,   2018年09月
  • 精神疾患を併存した慢性痛患者の診療における多職種連携の取り組みと経過分析, 太田 晴子, 浅井 明倫, 酒井 美枝, 藤掛 数馬, 加藤 利奈, 加古 英介, 徐 民恵, 草間 宣好, 杉浦 健之, 祖父江 和哉, 日本ペインクリニック学会誌,   2018年06月
  • 2型糖尿病モデルマウス(TSODマウス)を用いた耐糖能異常ニューロパチーの発症機序の検討, 志田恭子, 大澤匡弘, 太田晴子, 田村哲也, 祖父江和哉, 第22回日本神経麻酔集中治療学会,   2018年06月
  • 小児において血糖値が150mg/dL未満であれば高乳酸血症の可能性は低い, 伊藤 秀和, 祖父江 和哉, 日本小児救急医学会雑誌,   2018年04月
  • 培養アストロサイト発現ネプリライシンとインスリン分解酵素のインスリンによる発現調節の検討, 山本直樹, 谷田守, 石黒凌, 祖父江和哉, 日本薬学会第138回年会,   2018年03月
  • 肺切除術後の無気肺の管理に難渋した炎症性筋線維芽細胞性腫瘍の一例, 野木村茜, 井口広靖, 長沼愛友, 衣笠梨絵, 加藤利奈, 太田晴子, 加古英介, 徐民恵, 田村哲也, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • 右房粘液腫摘出術後の心房間シャントにより術後管理に難渋した一例, 衣笠梨絵, 佐野文昭, 野木村茜, 松山周平, 太田一志, 長沼愛友, 仙頭佳起, 加古英介, 草間宣好, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • ハロペリドールによる錐体外路症状が疑われた幼児の1例, 上村友二, 平手博之, 関谷憲晃, 小笠原治, 仙頭佳起, 佐野文昭, 伊藤秀和, 徐民恵, 田村哲也, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • Rapid Response System起動件数増加と早期起動のための取り組みとその効果, 丸谷幸子, 仙頭佳起, 岩田麻衣子, 大佐賀智, 鈴木伴枝, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • 不十分な体制でもRRSは時間外に活動を拡張すべきである〜夜勤帯と休日の起動症例の検討〜, 仙頭佳起, 平手博之, 太田一志, 上村友二, 衣笠梨絵, 佐野文昭, 草間宣好, 丸谷幸子, 大佐賀智, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • 当院における大量出血時のフィブリノゲン濃縮製剤の効果に関する現状調査, 佐野文昭, 平手博之, 松山周平, 関谷憲晃, 永井梓, 星加麻衣子, 井口広靖, 伊藤秀和, 加古英介, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • ICU入室時のNTproBNPによる小児心臓外科術後患者の予後予測, 加古英介, 吉澤佐也, 永井梓, 井上雅史, 小笠原治, 上村友二, 太田晴子, 徐民恵, 草間宣好, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • 「一歩進んだワーク・ライフ・バランスを考える」名古屋市立大学病院でのICU医師の働き方, 田村哲也, 平手博之, 佐野文昭, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • ICUにおけるMRSA検出に関連する危険因子の検討, 板津良, 矢野久子, 安岡砂織, 田村哲也, 平手博之, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年02月
  • Difficult Airway Management in Cervical Laminoplasty For a Patient with Multiple Hemangiomas in the Neck, Thyroid, Oral Cavity and the Pharynx., Sano F, Kako E, Sobue K, Annual Meeting of the American Society of Anesthesiolosists(ASA),   2018年
  • Successfully Managing An Airway Emergency In Children., Tamura T, So M, Sano F, Sobue K, Annual Meeting of the American Society of Anesthesiolosists(ASA),   2018年
  • 高齢化社会における周術期の高次脳機能保護, 祖父江和哉, 島根麻酔医学会第33回大会,   2018年
  • Rapid Response Systemの実績から検討した術後有害事象のリスク患者(多施設共同レジストリの解析), 仙頭佳起, In-Hospital Emergency Registry in, Japan collaborators, 上村友二, 平手博之, 祖父江和哉, 日本臨床麻酔学会第38回大会,   2018年
  • 高度低肺機能の先天性骨形成不全症患者の上腕手術に対して腕神経叢ブロックで管理を行った1例, 長沼愛友, 徐民恵, 太田一志, 大矢真, 衣笠梨絵, 藤掛数馬, 杉浦健之, 祖父江和哉, 日本臨床麻酔学会第38回大会,   2018年
  • 分娩進行中にくも膜下出血を発症し手術室で経腟分娩を行った一例, 伊藤遥, 藤掛数馬, 大矢真, 衣笠梨絵, 上村友二, 徐民恵, 草間宣好, 祖父江和哉, 日本臨床麻酔学会第38回大会,   2018年
  • 術前気道評価にレーザー光三次元造形機で作製した気道模型を活用した1例, 太田一志, 杉浦健之, 伊藤遥, 長沼愛友, 上村友二, 仙頭佳起, 草間宣好, 祖父江和哉, 日本臨床麻酔学会第38回大会,   2018年
  • 個別調査部会の委員の立場から, 祖父江和哉, 日本臨床麻酔学会第38回大会,   2018年
  • 気管切開に至った気管内魚骨椎体異物の一例, 伊藤秀和, 祖父江和哉, 日本小児麻酔学会第24回大会,   2018年
  • 小児のリアルタイム超音波ガイド下中心静脈穿刺ー成功率を高めるための工夫:皮膚牽引静脈拡張法ー, 森田正人, 笹野寛, 祖父江和哉, 日本小児麻酔学会第24回大会,   2018年
  • 当院で脊髄くも膜下麻酔中に心停止に至った3症例の検討, 森下文子, 星加麻衣子, 上村友二, 井口広靖, 杉浦健之, 祖父江和哉, 日本麻酔科学会東海・北陸支部第16回学術集会,   2018年
  • 小児開心術において人工心肺中にシリンジポンプからの突然の薬液ボーラス投与により循環変動を来した一例, 関谷憲晃, 太田晴子, 藤掛数馬, 徐民恵, 草間宣好, 祖父江和哉, 日本麻酔科学会東海・北陸支部第16回学術集会,   2018年
  • 腹腔鏡手術中の尿量は術後のAKIと相関しない, 伊藤遥, 加古英介, 仙頭佳起, 佐野文昭, 平手博之, 祖父江和哉, 日本麻酔科学会東海・北陸支部第16回学術集会,   2018年
  • 術後早期回復を目的とした周術期管理を再考する, 祖父江和哉, 日本麻酔科学会東海・北陸支部第16回学術集会,   2018年
  • 認知機能に対する麻酔薬の影響を考える, 祖父江和哉, 日本麻酔科学会中国・四国支部第55回学術集会,   2018年
  • 「愛知県小児重症患者相談システム」の運用により救命し得た完全房室ブロックの1例, 松山周平, 伊藤秀和, 上村友二, 仙頭佳起, 田村哲也, 徐民恵, 池山貴也, 祖父江和哉, 日本集中治療医学会第2回東海北陸支部学術集会,   2018年
  • 診断に難渋したメタノール中毒の一例, 長沼愛友, 佐野文昭, 井上雅史, 井口広靖, 太田晴子, 加古英介, 平手博之, 祖父江和哉, 日本集中治療医学会第2回東海北陸支部学術集会,   2018年
  • 栄養管理のABC, 祖父江和哉, 日本集中治療医学会第2回東海北陸支部学術集会,   2018年
  • 人工心肺後の急性腎障害早期診断における尿中L-FABPの有用性の検討, 伊藤秀和, 森下文子, 松山周平, 長沼愛友, 小笠原治, 星加麻衣子, 草間宣好, 祖父江和哉, 日本集中治療医学会第2回東海北陸支部学術集会,   2018年
  • 周術期の誤薬・誤注対策, 祖父江和哉, 周術期管理チームセミナー,   2018年
  • 世界の現状から見たガイドライン(講演), 東別府直紀, 讃井將満, 祖父江和哉, 日本麻酔科学会第65回学術集会,   2018年
  • 周術期口腔ケア外来における歯科介入の有用性の検討 −麻酔科医は術前の動揺歯を見落としている−, 衣笠梨絵, 草間宣好, 太田一志, 森下文子, 仙頭佳起, 祖父江和哉, 日本麻酔科学会第65回学術集会,   2018年
  • 塩化ベンザルコニウムは持続的な消毒効果により衛生的な経鼻気管挿管の環境を提供できる, 佐藤會士, 奥村陽子, 加古英介, 伊藤秀和, 祖父江和哉, 原田純, 日本麻酔科学会第65回学術集会,   2018年
  • 二腔式気管チューブによる嗄声の発生状況調査と危険因子の検討, 上村友二, 徐民恵, 長沼愛友, 関谷憲晃, 井上雅史, 祖父江和哉, 日本麻酔科学会第65回学術集会,   2018年
  • 小児心臓手術後の NT-proBNP値は左室の駆出率と相関するか?, 加古英介, 田村哲也, 野木村茜, 梶山加奈枝, 播磨恵, 祖父江和哉, 日本麻酔科学会第65回学術集会,   2018年
  • 医学生主導の参加型麻酔実習は指導医の経験年数によらず高い教育効果が得られる, 伊藤秀和, 平手博之, 加藤利奈, 佐野文昭, 太田晴子, 祖父江和哉, 日本麻酔科学会第65回学術集会,   2018年
  • 開腹手術における術中深部静脈血栓症の発生率調査と術直後スクリーニングの意義, 藤掛数馬, 井口広靖, 松山周平, 大矢真, 星加麻衣子, 祖父江和哉, 日本麻酔科学会第65回学術集会,   2018年
  • 周術期管理におけるバーコードの活用による医療安全の向上, 祖父江和哉, 日本麻酔科学会第65回学術集会,   2018年
  • 帝王切開術後の硬膜穿刺後頭痛に対する五苓散の有用性の検討, 浅井明倫, 永井梓, 加藤利奈, 草間宣好, 徐民恵, 杉浦健之, 大堀久, 薊隆文, 祖父江和哉, 東海・北陸ペインクリニック学会第29回東海地方会,   2018年
  • アクセプタンス&コミットメント・セラピーが有効であった慢性疼痛をかかえ休職している中年女性の1症例, 酒井美枝, 浅井明倫, 太田晴子, 近藤真前, 杉浦健之, 祖父江和哉, 東海・北陸ペインクリニック学会第29回東海地方会,   2018年
  • 食道癌術後の難治性胃管肺瘻に対する胃管離断術を脊髄くも膜下硬膜外併用麻酔にて良好に管理し得た一例, 永井梓, 太田晴子, 浅井明倫, 仙頭佳起, 星加麻衣子, 徐民恵, 草間宣好, 杉浦健之, 祖父江和哉, 日本区域麻酔学会第5回学術集会,   2018年
  • Fynによる新生ニューロン間接着機構の解明, 藤掛数馬, 澤田雅人, 澤本和延, 祖父江和哉, 第45回日本集中治療医学会学術集会,   2018年
  • アコニンサン錠が有効であった高齢者の帯状疱疹後神経痛の1症例, 浅井明倫, 永井梓, 仙頭佳起, 草間宣好, 祖父江和哉, 第30回日本老年麻酔学会,   2018年
  • 術後肺炎の発症に影響を与える因子の検討, 永井梓, 草間宣好, 浅井明倫, 仙頭佳起, 祖父江和哉, 第30回日本老年麻酔学会,   2018年
  • 高齢者に最適な麻酔薬の選択 〜術後回復の観点から〜, 仙頭佳起, 永井梓, 浅井明倫, 草間宣好, 祖父江和哉, 第30回日本老年麻酔学会,   2018年
  • 全前置胎盤に対する帝王切開において総腸骨動脈バルーン遮断が奏功しなかった1例, 関谷憲晃, 上村友二, 梶山加奈枝, 衣笠梨絵, 播磨恵, 徐民恵, 草間宣好, 祖父江和哉, 日本臨床麻酔学会第37回大会,   2017年10月
  • 帝王切開術後の硬膜穿刺後頭痛にカフェインと五苓散の併用が著効した1症例, 浅井明倫, 杉浦健之, 草間宣好, 徐民恵, 太田晴子, 加藤利奈, 薊隆文, 梶山加奈枝, 祖父江和哉, 東海・北陸ペインクリニック学会第28回東海地方会,   2017年10月
  • 循環管理に難渋した肥大型心筋症患者の全身麻酔管理, 佐藤 曾士, 森田 麻希, 渋谷 恭之, 原田 純, 祖父江 和哉, 日本歯科麻酔学会雑誌,   2017年09月
  • 左肺低形成と馬蹄肺を有する幼児患者の口唇形成術に対する全身麻酔経験, 森田 麻希, 佐藤 曾士, 渋谷 恭之, 原田 純, 祖父江 和哉, 日本歯科麻酔学会雑誌,   2017年09月
  • 短軸・長軸同時表示可能な超音波診断装置の血管カテーテル挿入時における有用性, 笹野 寛, 重政 勇介, 五島 隆宏, 山岸 庸太, 三浦 敏靖, 松嶋 麻子, 祖父江 和哉, 谷内 仁, 大野 貴之, 安藤 雅樹, 服部 友紀, 日本救急医学会雑誌,   2017年09月
  • 術後の患者調節鎮痛法(PCA)に関する患者理解度の調査, 榊原諒子, 仙頭佳起, 羽藤実真, 岡田悠揮, 祖父江和哉, 第39回日本手術医学会,   2017年09月
  • 薬剤師主導による静脈内患者調節鎮痛薬剤減量プロトコル作成とその評価, 羽藤実真, 仙頭佳起, 榊原諒子, 岡田悠揮, 祖父江和哉, 第39回日本手術医学会,   2017年09月
  • がん治療における合併症の予防のためのチームのちから 周術期効率化のなかで患者の安全性と満足度を向上させるためのチームのちから, 仙頭 佳起, 祖父江 和哉, 第42回日本外科系連合学会学術集会,   2017年06月
  • 帯状疱疹関連痛における感覚症状の分析, 杉浦健之, 浅井明倫, 加藤利奈, 藤掛数馬, 太田晴子, 徐民恵, 草間宣好, 亀澤隆司, 薊隆文, 祖父江和哉, 日本ペインクリニック学会第51回大会,   2017年06月
  • 上腕動脈留置カテーテル抜去後の出血に対してカバードステンド留置により止血に成功した一例, 大矢真, 衣笠梨絵, 長谷川達也, 小出明里, 井上雅史, 寺島良幸, 浅井明倫, 仙頭佳起, 伊藤秀和, 太田晴子, 加古英介, 徐民恵, 祖父江和哉, 日本集中治療医学会第一回東海北陸支部学術集会,   2017年06月
  • J-PADガイドライン発表前後での大学病院ICUにおける痛み・不穏・せん妄管理とアウトカムの変化, 仙頭 佳起, 太田 晴子, 長谷川 達也, 衣笠 梨絵, 浅井 明倫, 佐野 文昭, 田村 哲也, 平手 博之, 大佐賀 智, 祖父江 和哉, 日本集中治療医学会雑誌,   2017年02月
  • SGLT2阻害薬により糖尿病性ケトアシドーシスを発症した2型糖尿病の1例, 永井 梓, 吉澤 佐也, 大矢 真, 井上 雅史, 衣笠 梨絵, 加藤 利奈, 太田 晴子, 平手 博之, 草間 宣好, 祖父江 和哉, 日本集中治療医学会雑誌,   2017年02月
  • Post Anesthesia Care UnitにおけるレスピラトリーモニタPM1000Nの精度調査, 上村 友二, 平手 博之, 梶山 加奈枝, 永井 梓, 井上 雅史, 星加 麻衣子, 佐野 文昭, 太田 晴子, 大佐賀 智, 祖父江 和哉, 日本集中治療医学会雑誌,   2017年02月
  • 国際栄養調査2014の結果 本邦ICUでは経腸栄養は遅く投与量は少ない, 東別府 直紀, 讃井 將満, 祖父江 和哉, 西岡 弘晶, 日本静脈経腸栄養学会雑誌,   2017年01月
  • A case of paraplegia following elective surgical repair for a pararenal abdominal aortic aneurysm., Sano F, Sobue K, Annual Congress of the American Society of Critical Care Medicine(SCCM) 46th Critical Care Congres,   2017年
  • The Effect of a Rapid Response System on Postoperative Patients., Sento Y, Naito T, Atagi K, Fujitani S, Osaga S, Sobue K, A Nationwide Database Analysis Society of Critical Care Medicine 46th Critical Care Congres,   2017年
  • Sciatic Nerve Block as a Treatment of Lymphedema-induced Leg Pain, Kusama N, Sobue K, Annual Meeting of the American Society of Anesthesiolosists(ASA),   2017年
  • Is Peripherel Nerve Block Effective For Ischemic Pain?, So M, Sugiura T, Asai A, Tamura T, Kusama N, Sobue K, Annual Meeting of the American Society of Anesthesiolosists(ASA),   2017年
  • What is the optimal airway management for bronchial thermoplasty in patients with severe asthma?, Tamura T, Kusama N, So M, Koide A, Sobue K, Annual Meeting of the American Society of Anesthesiolosists(ASA),   2017年
  • 脊髄くも膜下麻酔と頓用鎮痛薬による帝王切開術後の状況-当院の現状調査-, 野木村茜, 仙頭佳起, 浅井明倫, 永井梓, 岡野将典, 吉澤佐也, 杉浦健之, 祖父江和哉, 日本臨床麻酔学会第37回大会,   2017年
  • 厳重なモニタリングにより甲状腺全摘出直後の咽頭浮腫による窒息を回避できた1例, 梶山加奈枝, 伊藤秀和, 大矢真, 藤掛数馬, 徐民恵, 祖父江和哉, 日本臨床麻酔学会第37回大会,   2017年
  • TSODマウスにおける痛み閾値の変化とTRPV1の関与, 丸岡純也, 志田恭子, 平手博之, 石倉啓一郎, 飯尾彩加, 粂和彦, 祖父江和哉, 大澤匡弘, 平成29年度日本薬学会東海支部例会,   2017年
  • インスリンによるアストロサイトのネプリライシンとインスリン分解酵素の発現調節の検討, 山本直樹, 谷田守, 石黒凌, 祖父江和哉, 第36回日本認知症学会学術集会,   2017年
  • 周術期管理センター設立を見据えた術後回復チームの結成, 岡田悠揮, 仙頭佳起, 祖父江和哉, 榊原諒子, 羽藤実真, 第39回日本手術医学会,   2017年
  • 経鼻気管挿管した気管チューブの完全閉塞をきたした乳児脳腫瘍摘出術の1例, 松山周平, 加古英介, 太田一志, 加藤利奈, 平手博之, 祖父江和哉, 日本麻酔科学会東海・北陸支部第15回学術集会,   2017年
  • 全身麻酔下に行った持続大腿神経ブロックで大腿神経麻酔をきたした1症例, 加藤利奈, 草間宣好, 井上雅史, 星加麻衣子, 太田晴子, 祖父江和哉, 日本麻酔科学会東海・北陸支部第15回学術集会,   2017年
  • 進行したDuchenne型筋ジストロフィー患者に全身麻酔科で胃瘻造設術を行った一例, 大矢真, 徐民恵, 衣笠梨絵, 星加麻衣子, 播磨恵, 祖父江和哉, 日本麻酔科学会東海・北陸支部第15回学術集会,   2017年
  • 敗血症がオキシトシンによる血圧低下を助長した帝王切開術の一例, 長沼愛友, 藤掛数馬, 野木村茜, 小笠原治, 佐野文昭, 祖父江和哉, 日本麻酔科学会東海・北陸支部第15回学術集会,   2017年
  • 神経保護因子エリスロポエチンがミクログリアの活性化に与える影響, 鳥内皐暉, 田村哲也, 青山峰芳, 垣田博樹, 祖父江和哉, 浅井清文, 第60回日本神経化学会大会,   2017年
  • 呼気のガス濃度を用いた吸気の平均酸素濃度の推定法, 薊隆文, 祖父江和哉, 播磨恵, 第35回日本麻酔・集中治療テクノロジー学会,   2017年
  • 心不全の栄養管理, 祖父江和哉, 2017年度日本静脈経腸栄養学会栄養士・管理栄養士部会,   2017年
  • 神経保護に働くエリスロポエチンはミクログリアの活性を沈静化する, 鳥内皐暉, 田村哲也, 青山峰芳, 垣田博樹, 祖父江和哉, 浅井清文, 第40回日本神経科学大会,   2017年
  • 膠原病に伴う四肢皮膚潰瘍に対して末梢神経ブロックによる疼痛管理を施行した10症例の検討, 太田晴子, 徐民恵, 梶山加奈枝, 小出明里, 浅井明倫, 加藤利奈, 杉浦健之, 大堀久, 笹野寛, 祖父江和哉, 日本ペインクリニック学会第51回大会,   2017年
  • Fyn-mediated control of cell-cell adhesion regulates detachment of chain-forming migrating neurons in the postnatal olfactory bulbs, 藤掛 数馬, 澤田 雅人, 匹田 貴夫, 服部 光治, 祖父江 和哉, 澤本 和延, 第39回日本神経科学大会,   2017年
  • 間質性肺炎患者の高地における酸素化能の変動, 薊隆文, 祖父江和哉, 笹野寛, 第39回日本呼吸療法医学会学術集会,   2017年
  • 術後早期回復を目指した周術期管理, 祖父江和哉, Enhanced Surgical Recovery Forun in Fukuoka,   2017年
  • Thiel法固定カダバーを用いた末梢神経ブロック講習の有用性とあり方の検討, 草間宣好, 徐民恵, 志田恭子, 上村友二, 太田晴子, 祖父江和哉, 日本麻酔科学会第64回学術集会,   2017年
  • 医学生主導の参加型麻酔の教育効果と今後のあり方, 伊藤秀和, 草間宣好, 佐野文昭, 太田晴子, 田村哲也, 祖父江和哉, 日本麻酔科学会第64回学術集会,   2017年
  • 単包アルコール綿の閉鎖式アクセスポート殺菌効果は開封後経時間的に変化するか, 梶山加奈枝, 加古英介, 関谷憲晃, 藤掛数馬, 加藤利奈, 祖父江和哉, 日本麻酔科学会第64回学術集会,   2017年
  • 超音波ガイド下大腿静脈穿刺の安全性を高めるための解剖学的検討, 井上雅史, 中井俊宏, 衣笠梨絵, 稲垣雅昭, 山崎潤二, 祖父江和哉, 日本麻酔科学会第64回学術集会,   2017年
  • 成人の難治性てんかん重積に対するケトン食の有効性の検討, 長谷川達也, 伊藤秀和, 寺島良幸, 田村哲也, 平手博之, 祖父江和哉, 日本麻酔科学会第64回学術集会,   2017年
  • 薬物減量プロトコル存在下での小児心臓外科手術後におけるIatrogenic Withdrawal Syndromeの発症状況調査と改善策の検討, 上村友二, 徐民恵, 浅井明倫, 藤掛数馬, 加古英介, 祖父江和哉, 日本麻酔科学会第64回学術集会,   2017年
  • PACU退室基準に痛みの項目を追加したことが術後鎮痛に与えた影響, 仙頭佳起, 杉浦健之, 伊藤秀和, 播磨恵, 大佐賀智, 祖父江和哉, 日本麻酔科学会第64回学術集会,   2017年
  • 当院における帝王切開術後の硬膜穿刺後頭痛に対する薬物治療の検討, 永井梓, 浅井明倫, 小笠原治, 岡野将典, 杉浦健之, 祖父江和哉, 日本麻酔科学会第64回学術集会,   2017年
  • 腹臥位手術中の心肺停止に対して円滑な集学的治療により救命できた一例, 関谷憲晃, 佐野文昭, 永井梓, 岡野将典, 小笠原治, 寺島良幸, 藤掛数馬, 田村哲也, 平手博之, 祖父江和哉, 日本集中治療医学会第一回東海北陸支部学術集会,   2017年
  • 神経ブロックに伴うSurgical Site Infection に留意して麻酔管理を行った栄養障害型表皮水疱症の1例, 杉浦健之, 浅井明倫, 星加麻衣子, 仙頭佳起, 吉澤佐也, 太田晴子, 徐民恵, 草間宣好, 永井梓, 祖父江和哉, 日本区域麻酔学会第4回学術集会,   2017年

競争的資金

  • 術後認知機能障害における脳内耐糖能異常の影響の解明と予防法の確立, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2018年04月 - 2021年03月
  • 海馬における神経細胞の新生低下に注目した慢性疼痛の発症機序解明, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2018年04月 - 2021年03月
  • 前頭前皮質機能に着眼した慢性疼痛発症メカニズムの解明と治療への応用, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2018年04月 - 2021年03月
  • アストロサイトのカリウム制御メカニズムに注目した新規脳浮腫治療法の探索, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2017年04月 - 2020年03月
  • 薬物性肝障害におけるホエイペプチドの肝障害保護効果の基礎的研究と臨床応用, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2017年04月 - 2020年03月
  • がん患者における術後認知機能障害の発症機序の解明と予防法の確立, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2017年04月 - 2020年03月
  • 糖尿病患者における術後痛増強への酸感受性イオンチャネルの関与の解析, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2016年04月 - 2019年03月
  • 糖尿病患者における術後認知機能障害の発症機序の解明と予防法の確立, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2016年04月 - 2019年03月
  • ミクログリアを介したエリスロポエチンの脳保護作用機序の解明と治療薬開発の基盤研究, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2016年04月 - 2019年03月
  • 疼痛認知における体性感覚と情動反応の分離に着眼した慢性疼痛治療法の開発, 日本学術振興会, 科学研究費助成事業 基盤研究B,   2016年04月 - 2019年03月
  • 認知症患者に対する安全な麻酔法と周術期の増悪予防法の確立, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2015年04月 - 2018年03月
  • 抗酸化作用に注目した人工呼吸器関連肺傷害予防法の開発, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2014年04月 - 2017年03月
  • 水チャネルに注目した重症感染症に伴う中枢神経障害の発生機序解明と新規治療法の開発, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2014年04月 - 2017年03月
  • 新規水チャネルの脳浮腫発症における機能の解析と新規脳浮腫治療薬の開発, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2013年04月 - 2016年03月
  • 周術期低酸素虚血後の脳白質傷害の発生機序解明と再生療法開発, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2013年04月 - 2016年03月
  • 痛み関連バイオマーカーの探索研究, 日本学術振興会, 科学研究費助成事業 挑戦的萌芽研究,   2012年04月 - 2015年03月
  • 人工呼吸器関連肺障害に対する二酸化炭素血症の保護作用機序解明と新規治療薬の開発, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2012年04月 - 2015年03月
  • アルツハイマー型認知症患者に対する麻酔薬の影響ー安全な麻酔法の確立をめざして−, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2012年04月 - 2015年03月
  • RNAiを用いたアクアポリン機能調節による脳浮腫抑制のin vivoへの応用, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2012年04月 - 2015年03月
  • 脊髄虚血後のASIC活性化制御による神経保護効果の検討, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2011年04月 - 2014年03月
  • 蘇生後低酸素症の脳浮腫発症における水チャネルの機能解析, 日本学術振興会, 科学研究費助成事業 若手研究(B),   2010年04月 - 2013年03月
  • 重症感染症に伴う中枢神経障害の発生機序解明と治療戦略開発, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2010年04月 - 2013年03月
  • 神経障害性疼痛モデルにおける神経分泌能解析〜痛覚過敏への末梢神経機能の関与, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2009年04月 - 2012年03月
  • 新規水チャネルの脳における機能解析-脳浮腫発症機序の解明に向けて-, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2009年04月 - 2012年03月
  • ノックダウンを用いた軽度低温の脳浮腫抑制効果に果たす水チャンネルの機能解析, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2009年04月 - 2012年03月
  • RNAiを用いた軽度低温の脳浮腫抑制効果に果たす水チャンネル機能の解析, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2006年04月 - 2009年03月
  • 水チャネル<アクアポリン>を標的とした新しい脳浮腫治療法の開発, 日本学術振興会, 科学研究費助成事業 基盤研究B,   2006年04月 - 2009年03月
  • 血管内皮前駆細胞移植による脳毛細血管再生と遺伝子治療への応用, 日本学術振興会, 科学研究費助成事業 萌芽研究,   2005年04月 - 2008年03月
  • 脳における水チャネル(アクアポリン)の機能調節と脳浮腫, 日本学術振興会, 科学研究費助成事業 基盤研究C,   2003年04月 - 2006年03月
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