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西尾 英紀ニシオ ヒデノリ

所属部署医学研究科小児泌尿器科学分野
職名助教
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Last Updated :2020/05/26

研究者基本情報

基本情報

    科研費研究者番号:10621063

研究活動情報

研究分野

  • ライフサイエンス, 泌尿器科学

論文

  • Detailed presurgical evaluation of a case of congenital bladder diverticulum., Nishio H, Mizuno K, Kamisawa H, Nakagawa M, Yasui T, Hayashi Y, Urology case reports, 27,   2019年11月, 査読有り
  • Scrotal abscess mimicking as intrascrotal liposarcoma., Nishio H, Iwatsuki S, Takada H, Kobayashi T, Mizuno K, Okada A, Umemoto Y, Yasui T, Urology case reports, 23, 62 - 64,   2019年03月, 査読有り
  • Single Nucleotide Polymorphisms of HAAO and IRX6 Genes as Risk Factors for Hypospadias., Kojima Y, Koguchi T, Mizuno K, Sato Y, Hoshi S, Hata J, Nishio H, Hashimoto D, Matsushita S, Suzuki K, Miyagawa S, Hui CC, Tanikawa C, Murakami Y, Yamada G, Hayashi Y, Matsuda K, The Journal of urology, 201, (2) 386 - 392,   2019年02月, 査読有り
  • Robotic surgery in pediatric urology: Current status., Mizuno K, Kojima Y, Nishio H, Hoshi S, Sato Y, Hayashi Y, Asian journal of endoscopic surgery, 11, (4) 308 - 317,   2018年11月, 査読有り
  • Urothelial carcinoma of the urinary bladder in a 12-year-old girl: A case report with immunohistological analysis and a review of the literature., Kato T, Mizuno K, Naiki T, Nishio H, Iida K, Moritoki Y, Ando R, Okada A, Yasui T, Hayashi Y, Urology case reports, 17, 29 - 31,   2018年03月, 査読有り
  • Can lichen sclerosus be diagnosed by preputial appearance or symptoms?, Kato T, Mizuno K, Nishio H, Moritoki Y, Nakane A, Kurokawa S, Kamisawa H, Maruyama T, Yasui T, Hayashi Y, Research and reports in urology, 10, 89 - 94,   2018年, 査読有り
  • Involvement of the bone morphogenic protein/SMAD signaling pathway in the etiology of congenital anomalies of the kidney and urinary tract accompanied by cryptorchidism, Kentaro Mizuno, Akihiro Nakane, Hidenori Nishio, Yoshinobu Moritoki, Hideyuki Kamisawa, Satoshi Kurokawa, Taiki Kato, Ryosuke Ando, Tetsuji Maruyama, Takahiro Yasui, Yutaro Hayashi, BMC UROLOGY, 17, (1) ,   2017年12月, 査読有り, Background: Congenital anomalies of the kidney and urinary tract (CAKUT), such as renal dysplasia, hydronephrosis, or vesicoureteral reflux, are the most common causes of end-stage renal disease. However, the genetic etiology of CAKUT remains unclear. In this study, we performed whole exome sequencing (WES) to elucidate the genetic etiology of symptomatic CAKUT and CAKUT accompanied by cryptorchidism. Methods: Three patients with unilateral renal dysplasia accompanied by ipsilateral cryptorchidism were included in this analysis. Genomic DNA was extracted from peripheral blood, and WES was performed. Disease-specific single nucleotide polymorphisms (SNPs) were determined by comparison with the human genome reference sequence (hg19). Additionally, we searched for SNPs that were common to all three patients, with a particular focus on the coding regions of the target genes. Results: In total, 8710 SNPs were detected. Of the genes harboring these SNPs, 32 associated with renal or testicular development were selected for further analyses. Of these, eight genes (i.e., SMAD4, ITGA8, GRIP1, FREM1, FREM2, TNXB, BMP8B, and SALL1) carried a single amino acid substitution that was common to all three patients. In particular, SNPs in SMAD4 (His290Pro and His291Pro) have not been reported previously in patients with symptomatic CAKUT. Of the candidate genes, four genes (i.e., ITGA8, GRIP1, FREM1, and FREM2) were Fraser syndrome-related genes, encoding proteins that functionally converged on the glial cell-derived neurotrophic factor/RET/bone morphogenic protein (BMP) signaling pathways. As another candidate gene, the protein encoded by BMP8B activates the nuclear translocation of SMAD4, which regulates the expression of genes associated with the differentiation of primordial germ cells or testicular development. Additionally, BMP4, a member of the BMP family, regulates the interaction between metanephric mesenchyme and ureteric buds by suppressing GDNF. Conclusions: Taken together, our findings suggested that the development of the kidney and urinary tract is intimately linked with that of male reproductive organs via BMP/SMAD signaling pathways.
  • New steps of robot-assisted radical prostatectomy using the extraperitoneal approach: a propensity-score matched comparison between extraperitoneal and transperitoneal approach in Japanese patients, Satoshi Kurokawa, Yukihiro Umemoto, Kentaro Mizuno, Atsushi Okada, Akihiro Nakane, Hidenori Nishio, Shuzo Hamamoto, Ryosuke Ando, Noriyasu Kawai, Keiichi Tozawa, Yutaro Hayashi, Takahiro Yasui, BMC UROLOGY, 17, (1) ,   2017年11月, 査読有り, Background: Robot-assisted radical prostatectomy (RARP) is commonly performed using the transperitoneal (TP) approach with six trocars over an 8-cm distance in the steep Trendelenburg position. In this study, we investigated the feasibility and the benefit of using the extraperitoneal (EP) approach with six trocars over a 4-cm distance in a flat or 5 degrees Trendelenburg position. We also introduced four new steps to the surgical procedure and compared the surgical results and complications between the EP and TP approach using propensity score matching. Methods: Between August 2012 and August 2016, 200 consecutive patients without any physical restrictions underwent RARP with the EP approach in a less than 5 degrees Trendelenburg position, and 428 consecutive patients underwent RARP with the TP approach in a steep Trendelenburg position. Four new steps to RARP using the EP approach were developed: 1) arranging six trocars; 2) creating the EP space using laparoscopic forceps; 3) holding the separated prostate in the EP space outside the robotic view; and 4) preventing a postoperative inguinal hernia. Clinicopathological results and complications were compared between the EP and TP approaches using propensity score matching. Propensity scores were calculated for each patient using multivariate logistic regression based on the preoperative covariates. Results: All 200 patients safely underwent RARP using the EP approach. The mean volume of estimated blood loss and duration of indwelling urethral catheter use were significantly lower with the EP approach than the TP approach (139.9 vs 184.9 mL, p = 0.03 and 5.6 vs 7.7 days, p < 0.01, respectively). No significant differences in the positive surgical margin were observed. None of the patients developed an inguinal hernia postoperatively after we introduced this technique. Conclusions: The EP approach to RARP was safely performed regardless of patient physique or contraindications to a steep Trendelenburg position. Our method, which involved using the EP approach to perform RARP, can decrease the amount of perioperative blood loss, the duration of indwelling urethral catheter use, and the incidence of postoperative inguinal hernia development.
  • A Rare Case of Epididymal Abscess in an Infant Treated Successfully with Needle Aspiration., Nishio H, Mizuno K, Kato T, Moritoki Y, Kamisawa H, Kurokawa S, Nakane A, Okada A, Yasui T, Hayashi Y, Urology case reports, 13, 26 - 27,   2017年07月, 査読有り
  • Robot-assisted laparoscopic pyeloplasty for ureteropelvic junction obstruction: comparison between pediatric and adult patients-Japanese series., Mizuno K, Kojima Y, Kurokawa S, Kamisawa H, Nishio H, Moritoki Y, Nakane A, Maruyama T, Okada A, Kawai N, Tozawa K, Kohri K, Yasui T, Hayashi Y, Journal of robotic surgery, 11, (2) 151 - 157,   2017年06月, 査読有り
  • KDM5A INHIBITS GONOCYTE DIFFERENTIATION TO SPERMATOGONIAL STEM CELLS BY SUPPRESSING RET GENE FUNCTION VIA EPIGENETIC REGULATION, Hidenori Nishio, Taiki Kato, Kentaro Mizuno, Yoshinobu Moritoki, Hideyuki Kamisawa, Satoshi Kurokawa, Akihiro Nakane, Tetsuji Maruyama, Yutaro Hayashi, Takahiro Yasui, JOURNAL OF UROLOGY, 197, (4) E542 - E543,   2017年04月, 査読有り
  • TESTICULAR HISTOLOGY IN INFANTS WITH PRADER-WILLI SYNDROME, Taiki Kato, Kentaro Mizuno, Hidenori Nishio, Yoshinobu Moritoki, Akihiro Nakane, Hideyuki Kamisawa, Satoshi Kurokawa, Tetsuji Maruyama, Takahiro Yasui, Yutaro Hayashi, JOURNAL OF UROLOGY, 197, (4) E863 - E864,   2017年04月, 査読有り
  • Hemiscrotal agenesis: Pathogenesis and management strategies, Hidenori Nishio, Kentaro Mizuno, Yoshinobu Moritoki, Hideyuki Kamisawa, Taku Naiki, Satoshi Kurokawa, Akihiro Nakane, Atsushi Okada, Takahiro Yasui, Yutaro Hayashi, INTERNATIONAL JOURNAL OF UROLOGY, 23, (6) 523 - 526,   2016年06月, 査読有り, Hemiscrotal agenesis is among the rarest anomalies in scrotal development disorders. As it has only been reported in three cases, the clinical manifestations remain unclear. We report a case of hemiscrotal agenesis with ipsilateral cryptorchidism. Based on the thermal assessment of the scrotum, concurrent scrotoplasty and orchiopexy were carried out, and the scrotoplasty improved the thermal environment of the fixed left testis. Furthermore, the low expression of androgen receptor and steroid-5-alpha-reductase, alpha polypeptide 2 in the affected side of the scrotum likely resulted in the characteristics of absent scrotal rugae, and pigmentation on histological and biological analyses. For future fertility, we believe that scrotoplasty should be considered as a management option for hemiscrotal agenesis.
  • KDM5A, A HISTONE H3K4 DEMETHYLASE, REGULATES SPERMATOGENESIS VIA ITS ACTION ON GERM CELL, Hidenori Nishio, Kentaro Mizuno, Moritoki Yoshinobu, Hideyuki Kamisawa, Akihiro Nakane, Satoshi Kurokawa, Tetsuji Maruyama, Yutaro Hayashi, Takahiro Yasui, JOURNAL OF UROLOGY, 195, (4) E848 - E848,   2016年04月, 査読有り
  • RELATIONSHIP BETWEEN SERTOLI CELL FUNCTION AND DIFFERENTIATION PROCESS OF SPERMATOGONIAL STEM CELLS IN CRYPTORCHID TESTES, Takashi Nagai, Kentaro Mizuno, Yutaro Hayashi, Hideyuki Kamisawa, Yoshinobu Moritoki, Hidenori Nishio, Satoshi Kurokawa, Akihiro Nakane, Tetsuji Maruyama, Takahiro Yasui, JOURNAL OF UROLOGY, 195, (4) E586 - E586,   2016年04月, 査読有り
  • Adrenal Neuroblastoma in an Adult: Effect of Radiotherapy on Local Progression after Surgical Removal., Kurokawa S, Mizuno K, Nakane A, Moritoki Y, Nishio H, Kamisawa H, Kubota Y, Okada A, Kawai N, Hayashi Y, Yasui T, Case reports in urology, 2016,   2016年, 査読有り
  • THE SPACE ENVIRONMENT INDUCES THE ENHANCEMENT OF CAVEOLIN EXPRESSION AND LEADS TO GERM CELL APOPTOSIS, Kamisawa Hideyuki, Mizuno Kentaro, Kurokawa Satoshi, Moritoki Yoshinobu, Nishio Hidenori, Nakane Akihiro, Maruyama Tetsuji, Fujita Keiji, Sasaki Shoichi, Hayashi Yutaro, Kojima Yoshiyuki, Kohri Kenjiro, JOURNAL OF UROLOGY, 193, (4) ,   2015年04月, 査読有り
  • Clear cell sarcoma of the kidney distinguished from synovial sarcoma using genetic analysis: a case report., Hirose M, Mizuno K, Kamisawa H, Nishio H, Moritoki Y, Kohri K, Hayashi Y, BMC research notes, 8,   2015年04月, 査読有り
  • A Case of Metastatic Urothelial Carcinoma Treated with Pemetrexed as Third-Line Chemotherapy with Discussion and Literature Review., Iida K, Kawai N, Naiki T, Etani T, Ando R, Nagai T, Sugiyama Y, Naiki-Ito A, Nishio H, Okada A, Kohri K, Yasui T, Case reports in oncology, 8, (3) 530 - 535,   2015年, 査読有り
  • Accessory Scrotum With Perineal Lipoma: Pathologic Evaluation Including Androgen Receptor Expression., Iida K, Mizuno K, Nishio H, Moritoki Y, Kamisawa H, Kurokawa S, Kohri K, Hayashi Y, Urology case reports, 2, (6) 191 - 193,   2014年11月, 査読有り
  • Extravesical robot-assisted laparoscopic ureteral reimplantation for vesicoureteral reflux: Initial experience in Japan with the ureteral advancement technique, Yutaro Hayashi, Kentaro Mizuno, Satoshi Kurokawa, Akihiro Nakane, Hideyuki Kamisawa, Hidenori Nishio, Yoshinobu Moritoki, Keiichi Tozawa, Kenjiro Kohri, Yoshiyuki Kojima, INTERNATIONAL JOURNAL OF UROLOGY, 21, (10) 1016 - 1021,   2014年10月, 査読有り, ObjectivesTo report our initial experience with robot-assisted laparoscopic extravesical ureteral reimplantation using the ureteral advancement technique. MethodsA total of 15 ureters from nine patients (age range 2-25 years) underwent robot-assisted laparoscopic extravesical ureteral reimplantation for the management of vesicoureteral reflux. The reflux was classified as grade I in one ureter, grade II in two ureters, grade III in seven ureters, grade IV in three ureters and grade V in two ureters. One of the five female patients had a bilateral duplex system, and reflux was observed in all four ureters. The da Vinci surgical system was utilized. Ureteral advancement was carried out in all cases. We also compared the operative outcomes between conventional laparoscopic procedure and robotic surgery. ResultsThe console time was 211.587.4min (median +/- standard deviation) in the bilateral cases and 144.0 +/- 40.8min in the unilateral cases. Urethral catheters were removed at one or two postoperative days. None of the patients suffered postoperative complications, such as urine leakage or urinary retention. Postoperative voiding cystourethrography showed that the reflux had been resolved in 14 of the 15 ureters (success rate 93.3%). In the remaining case, the reflux grade decreased from III to I. The operative outcomes of robotic surgery were favorable and safe compared with conventional laparoscopic procedure. ConclusionsOur preliminary results showed that robot-assisted laparoscopic surgery is a feasible and useful approach to extravesical ureteral reimplantation, even for patients with bilateral reflux.
  • Elucidation of Distinctive Genomic DNA Structures in Patients with 46, XX Testicular Disorders of Sex Development Using Genome Wide Analyses, Kentaro Mizuno, Yoshiyuki Kojima, Hideyuki Kamisawa, Yoshinobu Moritoki, Hidenori Nishio, Akihiro Nakane, Satoshi Kurokawa, Kenjiro Kohri, Yutaro Hayashi, JOURNAL OF UROLOGY, 192, (2) 535 - 541,   2014年08月, 査読有り, Purpose: Although several genes, including the SRY gene, are involved in testicular differentiation, the entire mechanism of this differentiation remains unclear. We performed genome wide analysis in patients with 46, XX testicular disorders of sex development to comprehensively elucidate the mechanisms of testicular differentiation. Materials and Methods: Whole genomic DNA was extracted from the peripheral blood of 4 patients with 46, XX testicular disorders of sex development who were SRY negative. Genomic DNA was hybridized to a GeneChip (R) human mapping 250K array set. Compared to normal female data, we detected common loss of heterozygosity and copy number variation regions in 4 patients using Genotyping Console (TM) software. Results: Loss of heterozygosity was detected in 19 regions of 11 chromosomes. A total of 27 genes or nearby genomic areas were included in the applicable regions. Copy number loss was recognized in 13 regions of 10 chromosomes, and these regions included 55 genes. Copy number gain was detected in 6 regions of 4 chromosomes, which included the upstream region of the SOX3 gene. Conclusions: The regions with loss of heterozygosity did not contain genes associated with testicular differentiation. However, the upstream area of the SOX3 gene, which is located in Xq27.1, was included in the region of copy number gain. These results suggest that high expression of the SOX3 gene led to testicular differentiation despite SRY gene loss. As this applicable area is not within a coding region, genome wide analyses were valuable for detecting the novel regions associated with testicular differentiation.
  • Distinctive Changes in Histone H3K4 Modification Mediated via Kdm5a Expression in Spermatogonial Stem Cells of Cryptorchid Testes, Hidenori Nishio, Yutaro Hayashi, Yoshinobu Moritoki, Hideyuki Kamisawa, Kentaro Mizuno, Yoshiyuki Kojima, Kenjiro Kohri, JOURNAL OF UROLOGY, 191, (5) 1564 - 1572,   2014年05月, 査読有り, Purpose: Gonocytes differentiate into spermatogonial stem cells, which make it possible to maintain spermatogenesis continuously throughout life. We previously reported attenuated spermatogonial stem cell activity in cryptorchid testes, which resulted in altered spermatogenesis and affected fertility. However, few groups have examined the differentiation process from gonocytes to spermatogonial stem cells. To clarify the underlying mechanisms comprehensively we performed microarray analysis to assess differential expression of transcripts between normal and undescended testes in juvenile rats. Materials and Methods: Using microarray analysis we compared whole mRNA expression of normal and cryptorchid testes in a rat model. We subsequently validated differential expression of candidate genes by real-time reverse transcriptase-polymerase chain reaction and performed immunohistochemistry. We also investigated the methylation status of histone H3K4 in cryptorchid testes and the GC-1 spermatogonial cell line. Results: We detected 24 up-regulated and 39 down-regulated genes. Of these genes Kdm5a expression was significantly higher in undescended testes. Immunohistochemistry showed that Kdm5a was localized in the nuclei of gonocytes, spermatogonia and spermatocytes. H3K4me2/me3 expression levels were decreased in undescended testes at 9 days postpartum. Furthermore, Kdm5a over expression in GC-1 cells led to increased expression of Esr2, Neurog3, Pou5f1, Ret and Thy1. Conclusions: Recent investigations revealed that not only genetic but also epigenetic regulation has a role in spermatogenesis. Kdm5a is likely involved in the transformation of gonocytes into spermatogonial stem cells by transcriptional regulation of specific genes via H3K4 histone modification. To our knowledge this is the first report of epigenetic analysis of germ cell differentiation during early spermatogenesis.
  • DISTINCTIVE CHANGES IN HISTONE H3K4 MODIFICATION MEDIATED VIA KDM5A EXPRESSION IN SPERMATOGONIAL STEM CELLS OF CRYPTORCHID TESTES, Hidenori Nishio, Yutaro Hayashi, Yoshinobu Moritoki, Hideyuki Kamisawa, Satoshi Kurokawa, Akihiro Nakane, Kentaro Mizuno, Tetsuji Maruyama, Yoshiyuki Kojima, Kenjiro Kohri, JOURNAL OF UROLOGY, 191, (4) E221 - E221,   2014年04月, 査読有り
  • Expression Profiling of microRNA in Cryptorchid Testes: miR-135a Contributes to the Maintenance of Spermatogonial Stem Cells by Regulating FoxO1, Yoshinobu Moritoki, Yutaro Hayashi, Kentaro Mizuno, Hideyuki Kamisawa, Hidenori Nishio, Satoshi Kurokawa, Shinya Ugawa, Yoshiyuki Kojima, Kenjiro Kohri, JOURNAL OF UROLOGY, 191, (4) 1174 - 1180,   2014年04月, 査読有り, Purpose: We elucidated the mechanism of spermatogonial stem cell disturbance of cryptorchidism and investigated the expression of miRNAs and their target genes in undescended testes. Materials and Methods: Using microarray analysis we compared total miRNA expression in unilateral undescended testes with that in contralateral descended and normal testes in a rat model of cryptorchidism. The model was derived by administering flutamide to pregnant Sprague Dawley (R) rats. We identified mRNA targets of miRNAs by bioinformatic analysis, followed by in situ hybridization and immunohistochemistry to localize candidate miRNAs and mRNAs, respectively. We also investigated whether miRNAs could inhibit target protein expression in vitro. Results: Microarray analysis and subsequent quantitative reverse transcriptase-polymerase chain reaction showed that only miR-135a was expressed at a lower level in undescended testes. We identified its target as FoxO1, which is essential for stem cell maintenance. miR-135a and FoxO1 localized to spermatogonial stem cells. FoxO1 localized to the spermatogonial stem cell nucleus less frequently in undescended testes, indicating that the activity of FoxO1, which acts as a transcription factor, is altered in undescended testes. Finally, miR-135a transfection into spermatogonia in vitro resulted in down-regulation of FoxO1 expression. Conclusions: In cryptorchid testes there is a decreased number of spermatogonial stem cells in which FoxO1 is activated, indicating that failure of spermatogonial stem cell maintenance results in spermatogenesis alteration. We also noted interaction between miR-135a and FoxO1, and propose that miR-135a contributes to spermatogonial stem cell maintenance through modulation of FoxO1 activity.
  • 膀胱尿管逆流に対する 腹腔鏡手術―膀胱外到達法―, 水野健太郎, 林祐太郎, 西尾英紀, 守時良演, 郡健二郎, 小島祥敬, 泌尿器外科, 27, (6) 929 - 933,   2014年
  • 逆流防止術, 水野健太郎, 林祐太郎, 西尾英紀, 神沢英幸, 戸澤啓一, 郡健二郎, 小島祥敬, Japanese Journal of Endourology, 27, (2) 303 - 307,   2014年
  • Gene expression profile during testicular development in patients with SRY-negative 46,XX testicular disorder of sex development., Mizuno K, Kojima Y, Kamisawa H, Moritoki Y, Nishio H, Kohri K, Hayashi Y, Urology, 82, (6) 1453.e1 - 7,   2013年12月, 査読有り
  • Can spongioplasty prevent fistula formation and correct penile curvature in TIP urethroplasty for hypospadias?, Hayashi Y, Mizuno K, Moritoki Y, Nakane A, Kato T, Kurokawa S, Kamisawa H, Nishio H, Kohri K, Kojima Y, Urology, 81, (6) 1330 - 1335,   2013年06月, 査読有り
  • CLINICAL FEATURES AND TESTICULAR MORPHOLOGY IN INFANTILE PATIENTS WITH KALLMANN SYNDROME, Hidenori Nishio, Kentaro Mizuno, Satoshi Kurokawa, Hideyuki Kamisawa, Makoto Imura, Yoshinobu Moritoki, Yasuhiro Shibata, Akihiro Nakane, Toshiki Kato, Tetsuji Maruyama, Yoshiyuki Kojima, Yutaro Hayashi, Kenjiro Kohri, JOURNAL OF UROLOGY, 189, (4) E289 - E289,   2013年04月, 査読有り
  • EXPEDIENCY OF EARLY ORCHIOPEXY FOR SPERMATOGONIAL STEM CELL ACTIVITY AND APOPTOSIS IN CRYPTORCHID TESTES, Kamisawa Hideyuki, Mizuno Kentaro, Imura Makoto, Moritoki Yoshinobu, Nishio Hidenori, Nakane Akihiro, Kato Toshiki, Maruyama Tetsuji, Hayashi Yutaro, Kohri Kenjiro, JOURNAL OF UROLOGY, 189, (4) ,   2013年04月, 査読有り
  • FUNCTIONAL ANALYSIS OF RHO SIGNALING CASCADE CONCERNED WITH CELL ADHESION IN THE PROCESS OF TESTICULAR DEVELOPMENT, Mizuno Kentaro, Hayashi Yutaro, Kamisawa Hideyuki, Moritoki Yoshinobu, Nishio Hidenori, Imura Makoto, Shibata Yasuhiro, Kurokawa Satoshi, Nakane Akihiro, Kato Toshiki, Maruyama Tetsuji, Kojima Yoshiyuki, Kohri Kenjiro, JOURNAL OF UROLOGY, 189, (4) ,   2013年04月, 査読有り
  • 停留精巣における造精機能障害と精巣固定術の効果, 神沢英幸, 水野健太郎, 西尾英紀, 守時良演, 井村誠, 黒川覚史, 林 祐太郎, 郡, 健二郎, 小島祥敬, 日本小児泌尿器科学会雑誌2013, 22, 45 - 50,   2013年
  • Transumbilical laparoendoscopic single-site gonadectomy for Turner's syndrome with Y-chromosome mosaicism, Kentaro Mizuno, Yoshiyuki Kojima, Hidenori Nishio, Keiichi Tozawa, Haruo Mizuno, Kenjiro Kohri, Yutaro Hayashi, JOURNAL OF PEDIATRIC UROLOGY, 8, (4) E39 - E42,   2012年08月, 査読有り, Laparoendoscopic single-site surgery (LESS), a minimally invasive procedure, is gaining widespread acknowledgment in pediatric urology. We report the case of a 7-year-old girl with Turner's syndrome with 45,XO/46,XY mosaicism, for whom bilateral prophylactic gonadectomy using LESS was performed. Histopathological findings revealed bilateral streak gonads. The surgical and cosmetic outcome was excellent. Diagnostic and therapeutic laparoscopy is essential for accurate clinical management of patients with disorders of sex development. Although this is only a single case report, it supports the theory that LESS is an exceedingly practical and superior technique for such children, since it provides excellent magnification, as well as allowing normal psychological development owing to the concealed scar. Further studies and long-term follow-up are required to evaluate the benefits and limitations of applying LESS in pediatrics. (C) 2012 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
  • Feasible etiology of vanishing testis regarding disturbance of testicular development: Histopathological and immunohistochemical evaluation of testicular nubbins, Kentaro Mizuno, Yoshiyuki Kojima, Hideyuki Kamisawa, Satoshi Kurokawa, Yoshinobu Moritoki, Hidenori Nishio, Yutaro Hayashi, Kenjiro Kohri, INTERNATIONAL JOURNAL OF UROLOGY, 19, (5) 450 - 456,   2012年05月, 査読有り, Objectives: To identify the causes of vanishing testis besides vascular events secondary to testicular torsion. Methods: A total of 102 boys with vanishing testis were treated in our hospital from 1984 to 2011. Of these cases, 91 testicular nubbins were excised. Immunohistochemical analysis of testicular nubbins was carried out using anti-Wilms tumor 1 antibody, which is a stable marker of Sertoli cells. Reverse transcription polymerase chain reaction was also carried out using Wilms tumor 1-specific primers. Results: Most testicular nubbins were associated with inguinal lesion (51 patients, 56.0%). Light microscopy showed that 11 patients (12.5%) had seminiferous tubules (with germ cells in three patients [3.4%]), and 77 patients lacked seminiferous tubules, some of which had calcification (26 patients, 29.5%), and/or deposition of hemosiderin (21 patients, 23.9%). Immunohistochemical analysis showed Wilms tumor 1 expression not only in the Sertoli cells of the seminiferous tubules in the seminiferous tubule-positive patients, but also in the interstitium of testicular nubbins in the seminiferous tubule-negative patients. Reverse transcription polymerase chain reaction showed Wilms tumor 1 messenger ribonucleic acid expression in the testicular nubbins of both seminiferous tubule-positive and tubule-negative patients. Conclusions: The presence of Wilms tumor 1-positive cells in the interstitium of vanishing testis lacking seminiferous tubules suggests that the disturbance of testicular development after Sertoli cell differentiation and during testicular tubule formation might be involved in the etiology of vanishing testis.
  • THE ROLE OF JARID1A IN SPERMATOGENESIS: EVALUATION OF TRANSCRIPTIONAL REGULATION BY HISTONE H3K4 METHYLATION, Hidenori Nishio, Yoshiyuki Kojima, Yoshinobu Moritoki, Makoto Imura, Hideyuki Kamisawa, Atsushi Okada, Kentaro Mizuno, Yukihiro Umemoto, Keiichi Tozawa, Yutaro Hayashi, Kenjiro Kohri, JOURNAL OF UROLOGY, 187, (4) E300 - E300,   2012年04月, 査読有り
  • CONTINUOUS ASPIRATION WITH SUBCUTANEOUS DRAIN AND WOUND CLOSURE BY DERMAL SUTURE REDUCE SURGICAL SITE INFECTIONS, FOCUSED ON RADICAL CYSTECTOMY CASES, Hirose Yasuhiko, Okamura Takehiko, Kobayashi Takahiro, Ando Ryosuke, Nakane Akihiro, Akita Hidetoshi, Nishio Hidenori, Moritoki Yoshinobu, Kohri Kenjiro, JOURNAL OF UROLOGY, 187, (4) ,   2012年04月, 査読有り
  • FEASIBLE ETIOLOGY OF VANISHING TESTIS REGARDING DISTURBANCE OF TESTICULAR DEVELOPMENT; HISTOPATHOLOGIC AND IMMUNOHISTOCHEMICAL EVALUATION OF TESTICULAR NUBBINS, Hayashi Yutaro, Mizuno Kentaro, Kojima Yoshiyuki, Moritoki Yoshinobu, Nishio Hidenori, Kamisawa Hideyuki, Kohri Kenjiro, JOURNAL OF UROLOGY, 187, (4) E556 - E557,   2012年04月, 査読有り
  • FUNCTIONAL ANALYSIS OF SPERMATOGONIAL STEM CELLS IN CRYPTORCHIDISM USING EEF1A1 AND TPT1 GENE EXPRESSION AS INDEXES OF CELL DIFFERENTIATION, Kentaro Mizuno, Yoshiyuki Kojima, Hideyuki Kamisawa, Satoshi Kurokawa, Makoto Imura, Yoshinobu Moritoki, Hidenori Nishio, Yasuhiro Shibata, Akihiro Nakane, Toshiki Kato, Tetsuji Maruyama, Yutaro Hayashi, Kenjiro Kohri, JOURNAL OF UROLOGY, 187, (4) E558 - E559,   2012年04月, 査読有り
  • THE HISTOLOGICAL REACTION OF FORESKIN AFTER TESTOSTERONE TREATMENT PRIOR TO HYPOSPADIAS SURGERY, Hidenori Nishio, Kentaro Mizuno, Yoshinobu Moritoki, Makoto Imura, Hideyuki Kamisawa, Atsushi Okada, Yukihiro Umemoto, Yoshiyuki Kojima, Keiichi Tozawa, Yutaro Hayashi, Kenjiro Kohri, JOURNAL OF UROLOGY, 187, (4) E650 - E650,   2012年04月, 査読有り
  • Successful treatment of primary malignant lymphoma of the penis by organ-preserving rituximab-containing chemotherapy, Shuzo Hamamoto, Keiichi Tozawa, Hideki Nishio, Noriyasu Kawai, Kenjiro Kohri, INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY, 17, (2) 181 - 184,   2012年04月, 査読有り, Primary penile lymphoma is extremely rare. Here we report the case of a 67-year-old man with the chief complaints of difficulty in urination and priapism, who was eventually diagnosed with primary malignant lymphoma of the penis. Pathological examination of excision biopsy of the left inguinal lymph node revealed malignant CD20+ diffuse large B-cell lymphoma. We treated this patient with a systemic rituximab-chemotherapy regimen and obtained good results, in terms of both functional and cosmetic outcomes. Soluble interleukin-2 receptor was a useful tumor marker for evaluating the therapeutic effect. The patient has been in remission for 10 months after the discontinuation of chemotherapy.
  • Clinical Features and Testicular Morphology in Patients with Kallmann Syndrome, Hidenori Nishio, Kentaro Mizuno, Yoshinobu Moritoki, Hideyuki Kamisawa, Yoshiyuki Kojima, Haruo Mizuno, Kenjiro Kohri, Yutaro Hayashi, UROLOGY, 79, (3) 684 - 686,   2012年03月, 査読有り, Kallmann syndrome (KS) is a genetic disorder characterized by the simultaneous occurrence of idiopathic hypogonadotropic hypogonadism (IHH) and anosmia. Here, we present 3 cases of KS with detailed description. In Case 1, testicular morphology was examined by testicular biopsy, and Leydig cells were examined by immunohistochemistry using antibodies against Ad4BP/SF1. Contrary to our predictions, the present study revealed the presence of Leydig cells in the testis. Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development. UROLOGY 79: 684-686, 2012. (C) 2012 Elsevier Inc.
  • 先天性泌尿器科疾患の発生機序の解明-停留精巣と尿道下裂の原因遺伝子の解析-, 林 祐太郎, 水野健太郎, 黒川覚史, 神沢英幸, 守時良演, 西尾英紀, 小島祥敬, 郡 健二郎, NAGOYA MEDICAL JOURNAL, 52, 205 - 211,   2012年
  • THE EFFICACY OF ENDOSCOPIC SURGERY FOR THE PEDIATRIC PATIENTS WITH VOIDING DISTURBANCE, Kentaro Mizuno, Yoshiyuki Kojima, Yoshinobu Moritoki, Hidenori Nishio, Hideyuki Kamisawa, Makoto Imura, Shoichi Sasaki, Yutaro Hayashi, Kenjiro Kohri, JOURNAL OF ENDOUROLOGY, 25, A264 - A264,   2011年11月, 査読有り
  • Laparoscopic Nephrectomy for Pelvic Multicystic Dysplastic Kidney, Hidenori Nishio, Yoshiyuki Kojima, Kentaro Mizuno, Hideyuki Kamisawa, Kenjiro Kohri, Yutaro Hayashi, UROLOGY, 78, (2) 434 - 436,   2011年08月, 査読有り, The management of multicystic dysplastic kidney (MCDK) is controversial. There has been a shift from routine surgical removal to nonoperative management. However, recently, an argument has emerged with regard to the management of MCDK, with several studies recommending surgical removal. We report a case of pelvic MCDK that was diagnosed and subsequently removed by a laparoscopic procedure. A laparoscopic approach to the renal and pelvic areas is a minimally invasive, safe, and effective procedure to diagnose and treat MCDK. We believe that laparoscopic nephrectomy should be offered as a management option to the families of children with unilateral MCDK. UROLOGY 78: 434-436, 2011. (C) 2011 Elsevier Inc.
  • LONG-TERM ASPIRATION WITH SUBCUTANEOUS DRAIN AND WOUND CLOSURE BY DERMAL SUTURE REDUCE SURGICAL SITE INFECTIONS, Yasuhiko Hirose, Ryosuke Ando, Akihiro Nakane, Hidetoshi Akita, Takehiko Okamura, Yoshinobu Moritoki, Hidenori Nishio, JOURNAL OF UROLOGY, 185, (4) E472 - E472,   2011年04月, 査読有り
  • Characterization of the urethral plate and the underlying tissue defined by expression of collagen subtypes and microarchitecture in hypospadias, Yutaro Hayashi, Kentaro Mizuno, Yoshiyuki Kojima, Yoshinobu Moritoki, Hidenori Nishio, Toshiki Kato, Satoshi Kurokawa, Hideyuki Kamisawa, Kenjiro Kohri, INTERNATIONAL JOURNAL OF UROLOGY, 18, (4) 317 - 322,   2011年04月, 査読有り, Objectives: Various types of minimally invasive surgical treatments, including transurethral resection of prostate (TURP), are being carried out in Japan for patients with benign prostatic hyperplasia (BPH). The aim of the present study was to elucidate the current status of perioperative care for these treatments by carrying out a nationwide survey. Methods: Assisted by the Japanese Endourology and ESWL Association, perioperative data from 157 institutions participating in this survey were collected and analyzed. Results: This survey included 3918 patients undergoing TURP, 242 TUR in saline (TURis), 638 holmium laser enucleation of the prostate (HoLEP), 90 holmium laser ablation (HoLAP) and 241 photoselective vaporization (PVP). Mean operative time was shorter in TURP (71 min) and longer in HoLEP (127). Although no transfusions were required in cases undergoing HoLAP or PVP, blood was frequently transfused in those undergoing TURis (25.6%), TURP (10.2%) and HoLEP (7.8%), and the difference was significant. During the hospital stay, the incidence of TUR-syndrome, postoperative bleeding requiring bladder irrigation, acute urinary retention/difficulty on micturition and pad use at discharge was highest in TURP (2.3%), TURis (7.9%), HoLAP (16.7%) and HoLEP (15.1%), respectively. Two patients undergoing TURP died (0.05%). The shortest mean postoperative hospital stay was for PVP (1.6 days, even if the readmission rate within 90 days was the highest in this same group; 6.2%). Perioperative care during hospital stay varied among the five types of procedures. Conclusions: This survey provides useful documentation on the current status of minimally invasive treatments for BPH in Japan. Complication rates for TURP are not significantly higher as compared with other procedures. Thus, TURP can still be considered as the gold standard for BPH treatment.
  • Seminomatous extragonadal germ cell tumor with complete obstruction of the superior vena cava responding to intensive chemotherapy., Moritoki Y, Kato T, Nishio H, Kamisawa H, Hirose Y, Ando R, Akita H, Okamura T, Journal of rural medicine : JRM, 6, (1) 32 - 34,   2011年, 査読有り

MISC

  • 思春期停留精巣モデルラットにおける血液精巣関門構成タンパクClaudin11の局在と精細胞の分化との関連, 加藤 大貴, 水野 健太郎, 西尾 英紀, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 28, (2) 149 - 149,   2019年06月
  • 急性胃腸炎罹患後に尿管結石嵌頓による腎後性腎不全を発症した幼児の1例, 加藤 大貴, 濱本 周造, 岡田 淳志, 安井 孝周, 水野 健太郎, 西尾 英紀, 林 祐太郎, 泌尿器科紀要, 65, (6) 233 - 233,   2019年06月
  • 腹腔鏡・ロボット支援腎盂形成術:エキスパートの技術 ロボット支援腎盂形成術のポイントと注意点, 水野 健太郎, 西尾 英紀, 林 祐太郎, 加藤 大貴, 黒川 覚史, 戸澤 啓一, 安井 孝周, 日本泌尿器科学会総会, 107回,   2019年04月
  • 小児泌尿器科医療における腹腔鏡手術・ロボット手術 膀胱尿管逆流に対するロボット支援逆流防止術, 西尾 英紀, 水野 健太郎, 林 祐太郎, 加藤 大貴, 中根 明宏, 丸山 哲史, 戸澤 啓一, 安井 孝周, 日本泌尿器科学会総会, 107回,   2019年04月
  • 思春期の停留精巣モデルラットにおける血液精巣関門関連タンパクの発現解析, 加藤 大貴, 水野 健太郎, 西尾 英紀, 中根 明宏, 丸山 哲史, 安井 孝周, 林 祐太郎, 日本泌尿器科学会総会, 107回,   2019年04月
  • 膀胱原発尿路上皮癌の女児例, 加藤 大貴, 西尾 英紀, 水野 健太郎, 林 祐太郎, 河合 憲康, 安井 孝周, 日本小児血液・がん学会雑誌, 56, (1) 69 - 69,   2019年04月
  • 小児泌尿器科疾患:成育医療へのリレー 停留精巣の造精障害に対する成育医療 補助生殖医療, 岩月 正一郎, 西尾 英紀, 水野 健太郎, 梅本 幸裕, 安井 孝周, 林 祐太郎, 日本泌尿器科学会総会, 107回,   2019年04月
  • 総排泄腔遺残に対して尿路・生殖器・消化管の完全分離・再建を行った1女児例, 西尾 英紀, 水野 健太郎, 加藤 大貴, 野崎 哲史, 中根 明宏, 窪田 泰江, 丸山 哲史, 安井 孝周, 林 祐太郎, 泌尿器科紀要, 64, (12) 525 - 525,   2018年12月
  • ロボット支援手術の新術式への拡大(骨盤臓器脱・膵臓癌・下咽頭癌・腎盂尿管移行部狭窄・その他) 小児水腎症に対するロボット支援腎盂形成術, 水野 健太郎, 西尾 英紀, 黒川 覚史, 加藤 大貴, 戸澤 啓一, 安井 孝周, 林 祐太郎, 日本内視鏡外科学会雑誌, 23, (7) WS18 - 3,   2018年12月
  • 小児腹腔鏡下腎盂形成 泌尿器科から・小児外科から ロボット支援腎盂形成術, 水野 健太郎, 西尾 英紀, 黒川 覚史, 加藤 大貴, 戸澤 啓一, 安井 孝周, 林 祐太郎, 日本内視鏡外科学会雑誌, 23, (7) WS21 - 8,   2018年12月
  • 膀胱Nephrogenic metaplasiaの一例, 高田 英輝, 梅本 幸裕, 岩月 正一郎, 西尾 英紀, 名古屋市立病院紀要, 40,   2018年09月, Nephrogenic metaplasiaは尿路に発生する比較的稀な良性腫瘍で、腎尿細管類似腺管様構造をもつ。発生機序として慢性炎症による尿路上皮の腎尿細管類似細胞への化生が有力とされてきたが、近年、腎尿細管細胞のimplantation説が考えられている。画像検査では尿路上皮癌と類似し、鑑別を要し、再発の報告もあるため定期的な経過観察が必要と考えられている。今回、膀胱に発生したnephrogenic metaplasiaを経験したので、若干の文献的考察を加え報告する。(著者抄録)
  • 尿道下裂の基礎研究と臨床研究 尿道下裂患者の精巣機能 思春期を迎えた患者の内分泌学的解析から, 岩月 正一郎, 西尾 英紀, 水野 健太郎, 梅本 幸裕, 加藤 大貴, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 27, (2) 171 - 171,   2018年06月
  • 片側停留精巣患者における不妊症発症に関わる臨床病理的検討 血清InhibinB値と精子幹細胞数の関連, 加藤 大貴, 水野 健太郎, 西尾 英紀, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 27, (2) 208 - 208,   2018年06月
  • 会陰部異所性精巣の1例 精巣組織と精巣導帯の病態生理学的解析, 加藤 大貴, 水野 健太郎, 西尾 英紀, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 27, (2) 210 - 210,   2018年06月
  • 精巣組織からセルトリ細胞を分離・精製する実験手技の確立 停留精巣における造精機能障害の原因究明を目指して, 加藤 大貴, 水野 健太郎, 西尾 英紀, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 27, (2) 230 - 230,   2018年06月
  • 小児における上部尿路結石の発生原因と24時間蓄尿の有用性, 加藤 大貴, 田口 和己, 水野 健太郎, 西尾 英紀, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 27, (2) 258 - 258,   2018年06月
  • 小児持続勃起症の3例, 加藤 大貴, 守時 良演, 西尾 英紀, 水野 健太郎, 安井 孝周, 林 祐太郎, 泌尿器科紀要, 64, (5) 240 - 240,   2018年05月
  • 【小児腹腔内精巣-どう扱うか?】腹腔鏡下精巣固定術 精巣血管の温存をめざして, 水野 健太郎, 西尾 英紀, 守時 良演, 加藤 大貴, 安井 孝周, 林 祐太郎, Japanese Journal of Endourology, 31, (1) 37 - 43,   2018年04月, 停留精巣の20〜35%は非触知であり、今日では診断・治療を目的として広く腹腔鏡手術が行われるようになった。私たちは非触知精巣に対して原則として全例で臍部からの腹腔鏡視を行い、消失精巣に対しても腹腔鏡のみで完遂するアルゴリズムで対応している。腹腔内精巣に対しては、精巣血管を遮断するFowler-Stephens法ではなく、できるだけ精巣血流を温存して精巣固定術を行う工夫を行ってきた。この理由として、精巣血流を遮断するFowler-Stephens法では、1.6〜5.5%の症例に精巣萎縮が見られることや、精巣発育についての長期成績が明らかでなく、症例数が限られているため十分なRCTが行われていないことが挙げられる。また、私たちが確立した停留精巣動物モデルを用いた基礎研究で、精巣血流の遮断によって精子形成が高度に障害されたことから、血流温存が精巣の機能維持に重要と考えられたことも、その理由の一つである。腹腔内精巣の血流を温存して精巣を下降させるために私たちは、(1)精巣血管の可及的頭側への剥離、(2)精巣血管の腹膜からの剥離、(3)trans scrotal trocarの利用、(4)良好な視野確保、といった点に注意して手術を行っている。本稿では、腹腔内精巣に対する腹腔鏡下精巣固定術において、私たちが行っている実際の手術方法を述べるとともに治療成績や問題点についても概説する。(著者抄録)
  • 無機能腎に対する腹腔鏡下腎摘除術・半腎摘除術, 西尾 英紀, 水野 健太郎, 加藤 大貴, 守時 良演, 戸澤 啓一, 安井 孝周, 林 祐太郎, Japanese Journal of Endourology, 30, (3) 120 - 120,   2017年11月
  • 巨大尿管に対して気膀胱下尿管形成術を施行した1例, 西尾 英紀, 水野 健太郎, 加藤 大貴, 守時 良演, 戸澤 啓一, 安井 孝周, 林 祐太郎, Japanese Journal of Endourology, 30, (3) 204 - 204,   2017年11月
  • 腹腔鏡下に切除した小児腎嚢胞の1例, 守時 良演, 水野 健太郎, 西尾 英紀, 加藤 大貴, 安井 孝周, 林 祐太郎, Japanese Journal of Endourology, 30, (3) 215 - 215,   2017年11月
  • 停留精巣におけるストレス応答因子 FOXO1、pCREBの発現, 守時 良演, 加藤 大貴, 水野 健太郎, 西尾 英紀, 梅本 幸裕, 林 祐太郎, 安井 孝周, 泌尿器科紀要, 63, (7) 288 - 289,   2017年07月
  • 停留精巣で高発現するKdm5aが造精機能障害に及ぼす影響 マイクロアレイ解析、IPA解析を用いた検討, 西尾 英紀, 水野 健太郎, 加藤 大貴, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 26, (2) 229 - 229,   2017年06月
  • 閉塞性乾燥性亀頭炎の臨床所見と病理組織学的所見の再考 包皮白色変化と瘢痕形成は閉塞性乾燥性亀頭炎の存在を示唆する, 加藤 大貴, 西尾 英紀, 守時 良演, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 26, (2) 283 - 283,   2017年06月
  • 精子幹細胞の分化過程におけるアンドロゲンの役割, 水野 健太郎, 守時 良演, 加藤 大貴, 西尾 英紀, 神沢 英幸, 中根 明宏, 黒川 覚史, 丸山 哲史, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 26, (1) 16 - 22,   2017年06月, 精子幹細胞は精巣における組織幹細胞であり、精子の供給源として働く。精子幹細胞は、始原生殖細胞から前駆細胞(gonocytes)をへて分化するが、その分化メカニズムの全容は明らかにされていない。本稿では、精子幹細胞の性質について、その特異的な細胞表面マーカーや、前駆細胞からの分化過程にかかわる因子、また、精子幹細胞の異常と疾患との関連性などについて、国内外から報告されている知見をまとめた。さらに、精子幹細胞の分化過程におけるアンドロゲンの関与について、私たちが行った研究結果を含めて概説する。(著者抄録)
  • 膀胱尿管逆流術後の尿中N-アセチル-β-D-グルコサミニダーゼ高値持続と分腎機能低下, 丸山 哲史, 西尾 英紀, 守時 良演, 加藤 大貴, 神沢 英幸, 黒川 覚史, 中根 明宏, 水野 健太郎, 林 祐太郎, 安井 孝周, 日本小児泌尿器科学会雑誌, 26, (1) 47 - 54,   2017年06月, 【目的】逆流性腎症を早期に予測することを目的とし、急性腎不全バイオマーカーの術後経過と腎機能経過との関連性を検討した。【方法】対象は逆流防止術後に尿路感染なく10年以上経過した38例。Dimercaptosuccinic acid(DMSA)腎シンチグラフィーを術前および術後1、3、5年で施行し、患側の相対摂取率で分腎機能を評価した。血中クレアチニン、尿中N-アセチル-β-D-グルコサミニダーゼ(NAG)、尿中α1マイクログロブリン(AMG)、血中レニン及びアルドステロンを術後継続的に測定した。【結果】尿中NAGは術後に26/29例(90%)で異常高値を認めたが、長期経過中に23例(80%)で改善した。高度逆流群の術後初回分腎機能改善率は6.8±9.2%で、軽度逆流群の-1.1±4.3%に比較し有意に高値であった(p=0.0365)。2例(7%)において尿中NAGの低値にもかかわらず長期経過中に分腎機能が低下した。血中クレアチニンは3例で高値、尿中AMGは1例、血中レニン及びアルドステロンは1例で高値であった。【結論】逆流防止術後に尿中NAGは高値持続したが徐々に改善し、可逆的な慢性炎症状態であったと推察された。今回の検討では尿中NAGの慢性腎不全予測マーカーとしての有効性は明らかではなかった。高度逆流を認めた症例においては逆流防止術による逆流圧消失効果が示唆された。(著者抄録)
  • 【小児科ケースカンファレンス】腎・泌尿器疾患、生殖器疾患 停留精巣, 林 祐太郎, 水野 健太郎, 守時 良演, 西尾 英紀, 加藤 大貴, 神沢 英幸, 小児科診療, 80, (増刊) 355 - 357,   2017年04月
  • 超音波検査で発見された軽度水腎症 診療アプローチと経過観察の仕方, 中根 明宏, 加藤 大貴, 西尾 英紀, 守時 良演, 黒川 覚史, 水野 健太郎, 林 祐太郎, 安井 孝周, 日本泌尿器科学会総会, 105回,   2017年04月
  • 小児泌尿器科領域におけるロボット手術の現況, 水野 健太郎, 黒川 覚史, 戸澤 啓一, 中根 明宏, 西尾 英紀, 加藤 大貴, 守時 良演, 梅本 幸裕, 林 祐太郎, 安井 孝周, 日本泌尿器科学会総会, 105回,   2017年04月
  • 小児泌尿器科学の基礎研究の未来を拓く, 水野 健太郎, 西尾 英紀, 守時 良演, 加藤 大貴, 林 祐太郎, 安井 孝周, 日本泌尿器科学会総会, 105回,   2017年04月
  • 小児先天性水腎症に対する術式の比較検討 多因子比較から検討した低侵襲手術の選択, 中根 明宏, 水野 健太郎, 林 祐太郎, 窪田 裕樹, 守時 良演, 西尾 英紀, 加藤 大貴, 安井 孝周, 日本泌尿器科学会総会, 105回,   2017年04月
  • 小児重複腎尿管に合併した尿管瘤・異所開口尿管・VUR 大変!どうすればいいの? 尿管瘤に対する気膀胱手術, 黒川 覚史, 水野 健太郎, 守時 良演, 西尾 英紀, 加藤 大貴, 林 祐太郎, 安井 孝周, Japanese Journal of Endourology, 29, (3) 130 - 130,   2016年11月
  • 小児腹腔内精巣 どう扱うか? 腹腔鏡下精巣固定術 精巣血管の温存をめざして, 水野 健太郎, 西尾 英紀, 守時 良演, 加藤 大貴, 林 祐太郎, 安井 孝周, Japanese Journal of Endourology, 29, (3) 134 - 134,   2016年11月
  • 【小児泌尿器科診療アップデート】停留精巣の諸問題 早期手術の有用性と問題点, 水野 健太郎, 西尾 英紀, 守時 良演, 加藤 大貴, 神沢 英幸, 林 祐太郎, 泌尿器外科, 29, (7) 1107 - 1114,   2016年07月, 停留精巣の大きな問題点は将来の妊孕性低下と悪性化である。診断・治療については2005年に本邦から、2014年に米国からガイドラインが提示され、現在では早期手術のコンセンサスは得られたと考えられる。本稿では、早期手術の有用性の裏づけとなるエビデンスを示しつつ、停留精巣にみられる精子幹細胞の機能異常などの最新の知見を交えて概説する。(著者抄録)
  • 停留精巣における造精機能障害・悪性化の原因遺伝子の同定 ヒト停留精巣組織を用いたマイクロアレイによる検討, 西尾 英紀, 加藤 大貴, 守時 良演, 林 祐太郎, 安井 孝周, 日本小児泌尿器科学会雑誌, 25, (3) 253 - 253,   2016年06月
  • 遺伝子・染色体異常疾患に合併した停留精巣の臨床的検討, 加藤 大貴, 水野 健太郎, 西尾 英紀, 林 祐太郎, 安井 孝周, 日本小児泌尿器科学会雑誌, 25, (3) 272 - 272,   2016年06月
  • Hemiscrotumの1例 発症機序の解明と手術方法の検討, 西尾 英紀, 水野 健太郎, 守時 良演, 神沢 英幸, 内木 拓, 黒川 覚史, 中根 明宏, 岡田 淳志, 安井 孝周, 林 祐太郎, 日本小児泌尿器科学会雑誌, 25, (1) 18 - 18,   2016年03月
  • Hemiscrotumの1例, 西尾 英紀, 水野 健太郎, 安藤 亮介, 岡田 淳志, 梅本 幸裕, 安井 孝周, 河合 憲康, 戸澤 啓一, 佐々木 昌一, 林 祐太郎, 郡 健二郎, 泌尿器科紀要, 61, (2) 76 - 76,   2015年02月
  • 同側に腹腔内精巣を伴う多嚢胞性異形成腎の1例, 安藤 亮介, 水野 健太郎, 西尾 英紀, 岡田 淳志, 梅本 幸裕, 河合 憲康, 戸澤 啓一, 佐々木 昌一, 林 祐太郎, 郡 健二郎, 泌尿器科紀要, 60, (4) 201 - 201,   2014年04月
  • 腎・膀胱Neuroendocrine carcinomaの1例, 岡田 淳志, 西尾 英紀, 濱川 隆, 新美 和寛, 井村 誠, 神沢 英幸, 水野 健太郎, 安井 孝周, 戸澤 啓一, 佐々木 昌一, 林 祐太郎, 郡 健二郎, 泌尿器科紀要, 59, (6) 396 - 396,   2013年06月
  • 肺がんの孤立性副腎転移に対する腹腔鏡下副腎摘除術の意義, 河合 憲康, 西尾 英紀, 岩月 正一郎, 井村 誠, 廣瀬 靖彦, 安藤 亮介, 水野 健太郎, 岡田 淳志, 窪田 泰江, 梅本 裕幸, 佐々木 昌一, 林 祐太郎, 郡 健二郎, 日本泌尿器科学会雑誌, 104, (2) 269 - 269,   2013年03月


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