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橋谷 光ハシタニ ヒカル

所属部署医学研究科細胞生理学分野
職名教授
メールアドレスhasitanimed.nagoya-cu.ac.jp
ホームページURL
生年月日
Last Updated :2019/10/12

研究者基本情報

学歴

  •  - 1991年, 九州大学, 医学部

学位

  • 名古屋市立大学医学研究科/博士(医学)

所属学協会

  • 日本生理学会
  • 日本平滑筋学会
  • 日本排尿機能学会

研究活動情報

研究分野

  • 基礎医学, 生理学一般

研究キーワード

    下部尿路, ペリサイト , 平滑筋, 細胞内カルシウム

論文

  • Role of K+ channels in regulating spontaneous activity in the muscularis mucosae of guinea pig bladder., Lee K, Isogai A, Antoh M, Kajioka S, Eto M, Hashitani H, European journal of pharmacology, 818, 30 - 37,   2018年01月, 査読有り
  • What are the origins and relevance of spontaneous bladder contractions? ICI-RS 2017., Drake MJ, Fry CH, Hashitani H, Kirschner-Hermanns R, Rahnama'i MS, Speich JE, Tomoe H, Kanai AJ, McCloskey KD, Neurourology and urodynamics,   2018年01月, 査読有り
  • Role of mucosa in generating spontaneous activity in the guinea pig seminal vesicle., Takeya M, Hashitani H, Hayashi T, Higashi R, Nakamura KI, Takano M, The Journal of physiology, 595, (14) 4803 - 4821,   2017年07月, 査読有り
  • Interstitial cell modulation of pyeloureteric peristalsis in the mouse renal pelvis examined using FIBSEM tomography and calcium indicators., Hashitani H, Nguyen MJ, Noda H, Mitsui R, Higashi R, Ohta K, Nakamura KI, Lang RJ, Pflugers Archiv : European journal of physiology, 469, (5-6) 797 - 813,   2017年06月, 査読有り
  • Contractile properties of periosteal arterioles in the guinea-pig tibia., Fukuta H, Mitsui R, Takano H, Hashitani H, Pflugers Archiv : European journal of physiology,   2017年05月, 査読有り
  • Nerve-induced responses of mouse vaginal smooth muscle., van Helden DF, Kamiya A, Kelsey S, Laver DR, Jobling P, Mitsui R, Hashitani H, Pflugers Archiv : European journal of physiology,   2017年05月, 査読有り
  • Properties of synchronous spontaneous Ca2+ transients in the mural cells of rat rectal arterioles., Mitsui R, Hashitani H, Pflugers Archiv : European journal of physiology,   2017年04月, 査読有り
  • Role of PTHrP and Sensory Nerve Peptides in Regulating Contractility of Muscularis Mucosae and Detrusor Smooth Muscle in the Guinea Pig Bladder., Lee K, Mitsui R, Kajioka S, Naito S, Hashitani H, The Journal of urology, 196, (4) 1287 - 1294,   2016年10月, 査読有り
  • Effects of K(+) channel openers on spontaneous action potentials in detrusor smooth muscle of the guinea-pig urinary bladder., Takagi H, Hashitani H, European journal of pharmacology, 789, 179 - 186,   2016年10月, 査読有り
  • Functional coupling of TRPV4 channels and BK channels in regulating spontaneous contractions of the guinea pig urinary bladder., Isogai A, Lee K, Mitsui R, Hashitani H, Pflugers Archiv : European journal of physiology, 468, (9) 1573 - 1585,   2016年09月, 査読有り
  • Mechanisms underlying spontaneous constrictions of postcapillary venules in the rat stomach., Mitsui R, Hashitani H, Pflugers Archiv : European journal of physiology, 468, (2) 279 - 291,   2016年02月, 査読有り
  • Spontaneous activity in the microvasculature of visceral organs: role of pericytes and voltage-dependent Ca(2+) channels., Hashitani H, Lang RJ, The Journal of physiology, 594, (3) 555 - 565,   2016年02月, 査読有り
  • Electrical properties of purinergic transmission in smooth muscle of the guinea-pig prostate., Lam M, Mitsui R, Hashitani H, Autonomic neuroscience : basic & clinical, 194, 8 - 16,   2016年01月, 査読有り
  • Pacemaker role of pericytes in generating synchronized spontaneous Ca2+ transients in the myenteric microvasculature of the guinea-pig gastric antrum., Hashitani H, Mitsui R, Masaki S, Van Helden DF, Cell calcium, 58, (5) 442 - 456,   2015年11月, 査読有り
  • Functional properties of submucosal venules in the rat stomach., Mitsui R, Hashitani H, Pflugers Archiv : European journal of physiology, 467, (6) 1327 - 1342,   2015年06月, 査読有り
  • Voltage dependence of slow wave frequency in the guinea pig prostate., Shigemasa Y, Lam M, Mitsui R, Hashitani H, The Journal of urology, 192, (4) 1286 - 1292,   2014年10月, 査読有り
  • Voltage-operated Ca(2) (+) currents and Ca(2) (+) -activated Cl(-) currents in single interstitial cells of the guinea-pig prostate., Lang RJ, Tonta MA, Takano H, Hashitani H, BJU international, 114, (3) 436 - 446,   2014年09月, 査読有り
  • Neurohumoral regulation of spontaneous constrictions in suburothelial venules of the rat urinary bladder., Shimizu Y, Mochizuki S, Mitsui R, Hashitani H, Vascular pharmacology, 60, (2) 84 - 94,   2014年02月, 査読有り
  • Altered detrusor gap junction communications induce storage symptoms in bladder inflammation: a mouse cyclophosphamide-induced model of cystitis., Okinami T, Imamura M, Nishikawa N, Negoro H, Sugino Y, Yoshimura K, Kanematsu A, Hashitani H, Ogawa O, PloS one, 9, (8) ,   2014年, 査読有り
  • Properties of submucosal venules in the rat distal colon., Mitsui R, Miyamoto S, Takano H, Hashitani H, British journal of pharmacology, 170, (5) 968 - 977,   2013年11月, 査読有り
  • Immunohistochemical characteristics of suburothelial microvasculature in the mouse bladder., Mitsui R, Hashitani H, Histochemistry and cell biology, 140, (2) 189 - 200,   2013年08月, 査読有り
  • PTHrP is endogenous relaxant for spontaneous smooth muscle contraction in urinary bladder of female rat., Nishikawa N, Kanematsu A, Negoro H, Imamura M, Sugino Y, Okinami T, Yoshimura K, Hashitani H, Ogawa O, Endocrinology, 154, (6) 2058 - 2068,   2013年06月, 査読有り
  • Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder., Hashitani H, Mitsui R, Shimizu Y, Higashi R, Nakamura K, British journal of pharmacology, 167, (8) 1723 - 1736,   2012年12月, 査読有り
  • Potassium and ANO1/ TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis., Iqbal J, Tonta MA, Mitsui R, Li Q, Kett M, Li J, Parkington HC, Hashitani H, Lang RJ, British journal of pharmacology, 165, (7) 2389 - 2408,   2012年04月, 査読有り
  • Spontaneous Ca2+ signaling of interstitial cells in the guinea pig prostate., Lam M, Shigemasa Y, Exintaris B, Lang RJ, Hashitani H, The Journal of urology, 186, (6) 2478 - 2486,   2011年12月, 査読有り
  • Functional properties of suburothelial microvessels in the rat bladder., Hashitani H, Takano H, Fujita K, Mitsui R, Suzuki H, The Journal of urology, 185, (6) 2382 - 2391,   2011年06月, 査読有り
  • Role of perinuclear mitochondria in the spatiotemporal dynamics of spontaneous Ca2+ waves in interstitial cells of Cajal-like cells of the rabbit urethra., Hashitani H, Lang RJ, Suzuki H, British journal of pharmacology, 161, (3) 680 - 694,   2010年10月, 査読有り
  • Functions of ICC-like cells in the urinary tract and male genital organs., Hashitani H, Lang RJ, Journal of cellular and molecular medicine, 14, (6A) 1199 - 1211,   2010年06月, 査読有り
  • Spontaneous electrical and Ca2+ signals in the mouse renal pelvis that drive pyeloureteric peristalsis., Lang RJ, Hashitani H, Tonta MA, Bourke JL, Parkington HC, Suzuki H, Clinical and experimental pharmacology & physiology, 37, (4) 509 - 515,   2010年04月, 査読有り
  • Distinct effects of CGRP on typical and atypical smooth muscle cells involved in generating spontaneous contractions in the mouse renal pelvis., Hashitani H, Lang RJ, Mitsui R, Mabuchi Y, Suzuki H, British journal of pharmacology, 158, (8) 2030 - 2045,   2009年12月, 査読有り
  • Role of K+ channels in regulating spontaneous activity in detrusor smooth muscle in situ in the mouse bladder., Hayase M, Hashitani H, Kohri K, Suzuki H, The Journal of urology, 181, (5) 2355 - 2365,   2009年05月, 査読有り
  • Altered distribution of interstitial cells in the guinea pig bladder following bladder outlet obstruction., Kubota Y, Hashitani H, Shirasawa N, Kojima Y, Sasaki S, Mabuchi Y, Soji T, Suzuki H, Kohri K, Neurourology and urodynamics, 27, (4) 330 - 340,   2008年, 査読有り
  • Role of nitric oxide/cyclic GMP pathway in regulating spontaneous excitations in detrusor smooth muscle of the guinea-pig bladder., Yanai Y, Hashitani H, Hayase M, Sasaki S, Suzuki H, Kohri K, Neurourology and urodynamics, 27, (5) 446 - 453,   2008年, 査読有り
  • Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ., Hashitani H, Suzuki H, The Journal of physiology, 583, (Pt 2) 505 - 519,   2007年09月, 査読有り
  • Spontaneous electrical and Ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of Cajal-like cells of mouse renal pelvis., Lang RJ, Hashitani H, Tonta MA, Parkington HC, Suzuki H, The Journal of physiology, 583, (Pt 3) 1049 - 1068,   2007年09月, 査読有り
  • Interaction between interstitial cells and smooth muscles in the lower urinary tract and penis., Hashitani H, The Journal of physiology, 576, (Pt 3) 707 - 714,   2006年11月, 査読有り
  • Heterogeneous CPA sensitivity of spontaneous excitation in smooth muscle of the rabbit urethra., Hashitani H, Yanai Y, Kohri K, Suzuki H, British journal of pharmacology, 148, (3) 340 - 349,   2006年06月, 査読有り
  • The role of Ni(2+)-sensitive T-type Ca(2+) channels in the regulation of spontaneous excitation in detrusor smooth muscles of the guinea-pig bladder., Yanai Y, Hashitani H, Kubota Y, Sasaki S, Kohri K, Suzuki H, BJU international, 97, (1) 182 - 189,   2006年01月, 査読有り
  • Atypical slow waves generated in gastric corpus provide dominant pacemaker activity in guinea pig stomach., Hashitani H, Garcia-Londoño AP, Hirst GD, Edwards FR, The Journal of physiology, 569, (Pt 2) 459 - 465,   2005年12月, 査読有り
  • Interaction between spontaneous and neurally mediated regulation of smooth muscle tone in the rabbit corpus cavernosum., Hashitani H, Yanai Y, Shirasawa N, Soji T, Tomita A, Kohri K, Suzuki H, The Journal of physiology, 569, (Pt 3) 723 - 735,   2005年12月, 査読有り
  • Role of interstitial cells and gap junctions in the transmission of spontaneous Ca2+ signals in detrusor smooth muscles of the guinea-pig urinary bladder., Hashitani H, Yanai Y, Suzuki H, The Journal of physiology, 559, (Pt 2) 567 - 581,   2004年09月, 査読有り
  • Correlation between spontaneous electrical, calcium and mechanical activity in detrusor smooth muscle of the guinea-pig bladder., Hashitani H, Brading AF, Suzuki H, British journal of pharmacology, 141, (1) 183 - 193,   2004年01月, 査読有り
  • Identification of interstitial cells of Cajal in corporal tissues of the guinea-pig penis., Hashitani H, Suzuki H, British journal of pharmacology, 141, (2) 199 - 204,   2004年01月, 査読有り
  • Electrical properties of detrusor smooth muscles from the pig and human urinary bladder., Hashitani H, Brading AF, British journal of pharmacology, 140, (1) 146 - 158,   2003年09月, 査読有り
  • Ionic basis for the regulation of spontaneous excitation in detrusor smooth muscle cells of the guinea-pig urinary bladder., Hashitani H, Brading AF, British journal of pharmacology, 140, (1) 159 - 169,   2003年09月, 査読有り
  • Role of mitochondria in the generation of spontaneous activity in detrusor smooth muscles of the Guinea pig bladder., Kubota Y, Hashitani H, Fukuta H, Kubota H, Kohri K, Suzuki H, The Journal of urology, 170, (2 Pt 1) 628 - 633,   2003年08月, 査読有り
  • Cellular mechanisms of nitric oxide-induced relaxation of corporeal smooth muscle in the guinea-pig., Hashitani H, Fukuta H, Dickens EJ, Suzuki H, The Journal of physiology, 538, (Pt 2) 573 - 581,   2002年01月, 査読有り
  • Origin and propagation of spontaneous excitation in smooth muscle of the guinea-pig urinary bladder., 橋谷 光, J Physiol., (530) 273 - 286,   2001年, 査読有り
  • Neuroeffector transmission to different layers of smooth muscle in the rat penile bulb., 橋谷 光, J Physiol., (524) 549 - 563,   2000年, 査読有り
  • Mechanisms of excitatory neuromuscular transmission in the guinea-pig urinary bladder., 橋谷 光, J Physiol., (524) 565 - 579,   2000年, 査読有り
  • Spontaneous and neurally activated depolarizations in smooth muscle cells of the guinea-pig urethra. , 橋谷 光, J Physiol., (514) 459 - 470,   1999年, 査読有り
  • Neuroeffector transmission in arterioles of the guinea-pig choroid., 橋谷 光, J Physiol, (510) 209 - 223,   1998年, 査読有り
  • K+ channels which contribute to the acetylcholine-induced hyperpolarization in smooth muscle of the guinea-pig submucosal arteriole.., 橋谷 光, J Physiol., (501) 319 - 329,   1997年, 査読有り
  • Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra., 橋谷 光, Br J Pharmacol. , (118) 1627 - 1632,   1996年, 査読有り

受賞

  •   2014年05月, American Urological Society, The Journal of Urology, Best reviewer 2014
  •   2010年05月, American Urological Society, The Journal of Urology, Best reviewer 2010
  •   1997年, 上原記念生命科学財団 ポストドクトラルフェローシップ
  •   2000年, 上原記念生命科学財団 研究奨励金
  •   2000年, 三井生命厚生事業団 医学研究助成
  •   1994年, 第1回日本神経因性膀胱学会学会賞

競争的資金

  • 泌尿生殖器系における間質細胞の多様性と普遍性に関する分子生理学的検討
  • 下部尿路平滑筋の自動運動に関する研究,   2003年 - 2004年
  • 不安定膀胱の成因としての平滑筋細胞間情報伝達の変化に関する研究,   2000年 - 2001年
  • 細胞間情報伝達系の制御による過活動膀胱に対する分子標的治療の研究


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