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北折 珠央キタオリ タマオ

所属部署医学研究科産科婦人科学分野
職名講師
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Last Updated :2020/06/02

研究者基本情報

学位

  • 名古屋市立大学/博士(医学)

所属学協会

  • 日本女性医学会
  • 日本産婦人科・新生児血液学会
  • 日本不育症学会
  • 日本生殖医学会
  • 日本周産期・新生児医学会
  • 日本生殖免疫学会
  • 日本産科婦人科学会

研究活動情報

研究キーワード

    抗リン脂質抗体, プロテアーゼ, 習慣流産

論文

  • Attitude and perceptions toward miscarriage: a survey of a general population in Japan., Banno C, Sugiura-Ogasawara M, Ebara T, Ide S, Kitaori T, Sato T, Ando K, Morita Y, Journal of human genetics,   2019年11月, 査読有り
  • Pathogenic roles of anti-C1q antibodies in recurrent pregnancy loss., Ohmura K, Oku K, Kitaori T, Amengual O, Hisada R, Kanda M, Shimizu Y, Fujieda Y, Kato M, Bohgaki T, Horita T, Yasuda S, Sugiura-Ogasawara M, Atsumi T, Clinical immunology (Orlando, Fla.), 203, 37 - 44,   2019年06月, 査読有り
  • Danaparoid is effective and safe for patients with obstetric antiphospholipid syndrome., Yoshihara H, Sugiura-Ogasawara M, Kitaori T, Katano K, Ozaki Y, Modern rheumatology, 1 - 6,   2019年03月, 査読有り
  • The first genome-wide association study identifying new susceptibility loci for obstetric antiphospholipid syndrome, Mayumi Sugiura-Ogasawara, Yosuke Omae, Minae Kawashima, Licht Toyo-Oka, Seik-Soon Khor, Hiromi Sawai, Tetsuya Horita, Tatsuya Atsumi, Atsuko Murashima, Daisuke Fujita, Tomio Fujita, Shinji Morimoto, Eriko Morishita, Shinji Katsuragi, Tamao Kitaori, Kinue Katano, Yasuhiko Ozaki, Katsushi Tokunaga, JOURNAL OF HUMAN GENETICS, 62, (9) 831 - 838,   2017年09月, 査読有り, Antiphospholipid syndrome (APS) is the most important treatable cause of recurrent pregnancy loss. The live birth rate is limited to only 70-80% in patients with APS undergoing established anticoagulant therapy. Lupus anticoagulant (LA), but not anticardiolipin antibody (aCL), was found to predict adverse pregnancy outcome. Recent genome-wide association studies (GWAS) of APS focusing on aCL have shown that several molecules may be involved. This is the first GWAS for obstetric APS focusing on LA. A GWAS was performed to compare 115 Japanese patients with obstetric APS, diagnosed according to criteria of the International Congress on APS, and 419 healthy individuals. Allele or genotype frequencies were compared in a total of 426 344 single-nucleotide polymorphisms (SNPs). Imputation analyses were also performed for the candidate regions detected by the GWAS. One SNP (rs2288493) located on the 3'-UTR of TSHR showed an experiment-wide significant APS association (P=7.85E-08, OR=6.18) under a recessive model after Bonferroni correction considering the number of analyzed SNPs. Another SNP (rs79154414) located around the C1D showed a genome-wide significant APS association (P=4.84E-08, OR=6.20) under an allelic model after applying the SNP imputation. Our findings demonstrate that a specific genotype of TSHR and C1D genes can be a risk factor for obstetric APS.
  • Genotyping analysis of the factor V Nara mutation, Hong Kong mutation, and 16 single-nucleotide polymorphisms, including the R2 haplotype, and the involvement of factor V activity in patients with recurrent miscarriage, Mari Izuhara, Keiko Shinozawa, Tamao Kitaori, Kinue Katano, Yasuhiko Ozaki, Katsuyuki Fukutake, Mayumi Sugiura-Ogasawara, BLOOD COAGULATION & FIBRINOLYSIS, 28, (4) 323 - 328,   2017年06月, 査読有り, Recurrent miscarriage can arise from a large diversity of causes and the factors responsible have not been fully clarified. The coagulation factor V R506Q (Leiden) mutation is a well known risk factor for recurrent miscarriage, although it has not been found in Japanese populations. We examined whether the factor V Nara and Hong Kong mutations, the factor V gene (F5) 16 single-nucleotide polymorphisms (SNPs), including the factor V R2 haplotype, and plasma factor V activity (FV:C) were risk factors for recurrent miscarriage. A cross-sectional study was conducted among 88 patients with a history of unexplained recurrent miscarriage and 95 fertile controls. None of the patients or controls was homozygous or heterozygous for the factor V Nara or Hong Kong mutation. In the 16 SNPs of F5, frequencies of the G/T and T/T genotypes at Ser156Ser were significantly lower in patients than in controls (OR 0.45, 95% CI 0.22-0.91, OR 0.32, 95% CI 0.14-0.72) and the allele frequency of C at Leu1288Leu was significantly higher in patients than that in controls (OR 1.66, 95% CI 1.02-2.71). The mean FV:C values were not significantly different between patients and controls. However, the prevalence of patients with a high or low FV:C (>95th or <fifth percentile) was significantly greater than the controls (OR 3.59, 95% CI 1.11-11.60: OR 3.94, 95% CI 1.23-12.60). These results suggest that some SNPs of F5 and a high or low FV:C level might be associated with recurrent miscarriage. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.
  • Genotyping analysis of protein S-Tokushima (K196E) and the involvement of protein S antigen and activity in patients with recurrent pregnancy loss, Yasushi Matsukawaa, Eriko Asano, Tomohide Tsuda, Hiroyuki Kuma, Tamao Kitaori, Kinue Katano, Yasuhiko Ozaki, Mayumi Sugiura-Ogasawara, EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, 211, 90 - 97,   2017年04月, 査読有り, Objective: Preston et al. indicated that Protein S (PS) deficiency was associated with stillbirths but not miscarriages. The PS-Tokushima missense variant was reported to serve as a genetic risk factor for deep vein thrombosis in the Japanese population. A previous cross-sectional study showed no increase in the prevalence of PS-Tokushima in patients with recurrent early pregnancy loss or in patients with intra uterine fetal death and/or fetal growth restriction. There has been limited number of prospective studies examining the pregnancy outcome in patients with both a PS deficiency and recurrent pregnancy loss (RPL). We examined the association between PS deficiency, PS-Tokushima and RPL. Study design: The study group consisted of 355 Japanese women with two or more consecutive pregnancy losses and 101 parous women. The frequency of PS-Tokushima and the subsequent live birth rate in relation to a PS deficiency defined as low PS-specific activity (total PS activity/total PS antigen) and the carriage of PS-Tokushima were examined. Results and conclusions: There was no significant difference in the frequency of PS-Tokushima between patients and controls. The 8 patients carriers of PS-Tokushima variant were capable of a subsequent live birth without the use of heparin. There was no significant difference in subsequent live birth rates between patients with low or normal PS-specific activity/PS activity without heparin prophylaxis after excluding miscarriages caused by an abnormal embryonic karyotype using multivariate logistic regression analysis. There was no association between PS Tokushima and RPL and a PS deficiency or low PS activity was shown not to serve as a reliable clinical predictor of subsequent miscarriage. (C) 2017 Elsevier B.V. All rights reserved.
  • Real-world practice of obstetricians in respect of assays for antiphospholipid antibodies., Sugiura-Ogasawara M, Atsumi T, Yamada H, Kitaori T, Ozaki Y, Katano K, Murashima A, Modern rheumatology, 25, (6) 883 - 887,   2015年, 査読有り
  • Genotyping Analysis for the 46 C/T Polymorphism of Coagulation Factor XII and the Involvement of Factor XII Activity in Patients with Recurrent Pregnancy Loss, Eriko Asano, Takeshi Ebara, Chisato Yamada-Namikawa, Tamao Kitaori, Nobuhiro Suzumori, Kinue Katano, Yasuhiko Ozaki, Makoto Nakanishi, Mayumi Sugiura-Ogasawara, PLOS ONE, 9, (12) ,   2014年12月, 査読有り, Background: Established causes of recurrent pregnancy loss (RPL) include antiphospholipid syndrome, uterine anomalies, parental chromosomal abnormalities, particularly translocations and abnormal embryonic karyotype. A systematic review concluded that coagulation factor XII (FXII) deficiency was associated with RPL. However, it could not be established whether the 46 C/T SNP of FXII or low activity of FXII was a risk factor for RPL, because of the small sample size. Methods and Findings: We conducted a cross-sectional and cohort study in 279 patients with two or more unexplained consecutive pregnancy losses and 100 fertile women. The association between the lupus anticoagulant (LA) activity and FXII activity was examined. The frequency of the CC, CT and TT genotypes and the FXII activity were also compared between the patients and controls. Subsequent miscarriage rates among the CC, CT, TT genotypes and according to the FXII activity was examined. LA was associated with reduced FXII activity. The CT, but not the TT, genotype was confirmed to be a risk factor for RPL in the cross-sectional study using multivariate logistic regression analysis (OR, 2.8; 95% CI, 1.37-5.85). The plasma FXII activity in the patients was similar to that in the controls. Neither low FXII activity nor the CT genotype predicted the subsequent pregnancy outcome in the cohort study. On the other hand, and intermediate FXII activity level of 85-101% was predictive of subsequent miscarriage. Conclusions: Low FXII activity was not associated with RPL. The FXII gene was found to be one of the significant susceptibility genes for RPL, similar to the FV Leiden mutation. However, the clinical influence of the CT genotype might be relatively small, because the presence/absence of this genotype did not have any predictive value for the subsequent pregnancy outcome. This was the first study indicating the influence of FXII 46C/T on further pregnancy outcomes.
  • Peripheral natural killer cell activity as a predictor of recurrent pregnancy loss: a large cohort study., Katano K, Suzuki S, Ozaki Y, Suzumori N, Kitaori T, Sugiura-Ogasawara M, Fertility and sterility, 100, (6) 1629 - 1634,   2013年12月, 査読有り
  • Genotyping analyses for polymorphisms of ANXA5 gene in patients with recurrent pregnancy loss, Yuko Hayashi, Hidefumi Sasaki, Sadao Suzuki, Takeshi Nishiyama, Tamao Kitaori, Eita Mizutani, Nobuhiro Suzumori, Mayumi Sugiura-Ogasawara, FERTILITY AND STERILITY, 100, (4) 1018 - 1024,   2013年10月, 査読有り, Objective: To investigate whether polymorphisms at the promoter or 5'-untranslated region of annexin A5 gene (ANXA5) influence miscarriage. Design: Case-control study and nested case-control study. Setting: Hospitals. Patient(s): A total of 264 patients with two to nine recurrent pregnancy losses (RPLs) and 195 fertile control subjects. Intervention(s): None. Main Outcome Measure(s): The frequency of six single-nucleotide polymorphisms (SNPs) of the ANXA5 gene in RPL patients versus control subjects, and subsequent live birth rate with and without risk alleles in RPL patients. Result(s): The minor allele was significantly more frequent in RPL patients than in control subjects for SNP5 (rs1050606). The live birth rates of patients with and without risk alleles of SNP5 were 84.0% and 84.3%, respectively, after excluding cases with abnormal embryonic karyotype, with no significant difference. Conclusion(s): The variations with the ANXA5 gene upstream region, especially SNP5, were confirmed to be risk factors of RPL. However, presence/absence of the ANXA5 risk allele did not have any predictive effect for subsequent pregnancy outcome. This was the first study indicating the influence of ANXA5 SNP5 for pregnancy outcome. (Fertil Steril (R) 2013;100:1018-24. (C) 2013 by American Society for Reproductive Medicine.)


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