Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2019/06 -2022/03
Author : TACHIKAWA Masanori
This study aims to validate our hypothesis that the blood-arachnoid barrier possesses the dynamic clearance system for neurotoxic substances in the cerebrospinal fluid and functions as a central nervus system detoxification system. The present study has proposed that α-synuclein, a pathogenic protein, which is known to be and accumulated in the brain of the Parkinson’s disease, would undergo the LDL receptor-related protein-mediated efflux transport from the cerebrospinal fluid. The study has also established the comprehensive proteomics and the LC-MS/MS-based targeted absolute quantification system for extracellular vesicles, pathogenic proteins, peptides, and metabolites to clarify various efflux transport system at the blood-arachnoid barrier.