SAITO Takashi

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SAITO Takashi

Professor

Last Updated :2025/03/28

Researcher Information

URL

https://ncs-saitolab.com/

Research funding number

90360552

J-Global ID

201201049431821560

Research Interests

疾患連関神経-グリア連関脳-末梢連関 astrocyte microglia タウサイトカイン/ケモカイン神経炎症ネプリライシンアルツハイマー病アミロイドβペプチド(Aβ) モデルマウスアミロイド前駆体蛋白質(APP) プレセニリン1(PS1) 創薬ノックインマウス神経ペプチド

Research Areas

Life sciences / Pathobiochemistry

Life sciences / Neuroscience - general

Life sciences / Pharmaceuticals - chemistry and drug development

Academic & Professional Experience

2019/07 - Today Nagoya City UniversityDepartment of Neurocognitive Science, Institute of Brain ScienceProfessor

2018/04 - 2019/06 RIKENLaboratory for Proteolytic NeuroscienceDeputy Team Leader

2011/11 - 2018/03 国立研究開発法人理化学研究所・神経蛋白制御研究チーム副チームリーダー

2012/10 - 2016/03 Japan Science and Technology Agencyさきがけ研究者（兼任）

2002/04 - 2011/10 RIKEN研究員

Education

1998/04 - 2002/03 大阪大学大学院医学系研究科生体制御医学専攻

1996/04 - 1998/03 Kumamoto University Kumamoto University 衛生薬学専攻

1992/04 - 1996/03 Kumamoto University School of Pharmacy 薬科学科

Association Memberships

日本神経科学会 Society for Neuroscience JAPAN SOCIETY FOR DEMENTIA RESEARCH THE JAPANESE BIOCHEMICAL SOCIETY

Published Papers

In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
Naoto Watamura; Martha S Foiani; Sumi Bez; Mathieu Bourdenx; Alessia Santambrogio; Claire Frodsham; Elena Camporesi; Gunnar Brinkmalm; Henrik Zetterberg; Saisha Patel; Naoko Kamano; Mika Takahashi; Javier Rueda-Carrasco; Loukia Katsouri; Stephanie Fowler; Emir Turkes; Shoko Hashimoto; Hiroki Sasaguri; Takashi Saito; Afm Saiful Islam; Seico Benner; Toshihiro Endo; Katsuji Kobayashi; Chiho Ishida; Michele Vendruscolo; Masahito Yamada; Karen E Duff; Takaomi C Saido
Nature neuroscience 2024/12 [Refereed]
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.Naoto Watamura; Martha S Foiani; Sumi Bez; Mathieu Bourdenx; Alessia Santa...See More
In vivo hyperphosphorylation of tau is associated with synaptic loss and behavioral abnormalities in the absence of tau seeds.
Naoto Watamura; Martha S Foiani; Sumi Bez; Mathieu Bourdenx; Alessia Santambrogio; Claire Frodsham; Elena Camporesi; Gunnar Brinkmalm; Henrik Zetterberg; Saisha Patel; Naoko Kamano; Mika Takahashi; Javier Rueda-Carrasco; Loukia Katsouri; Stephanie Fowler; Emir Turkes; Shoko Hashimoto; Hiroki Sasaguri; Takashi Saito; Afm Saiful Islam; Seico Benner; Toshihiro Endo; Katsuji Kobayashi; Chiho Ishida; Michele Vendruscolo; Masahito Yamada; Karen E Duff; Takaomi C Saido
Nature neuroscience 2024/12 [Refereed]

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation.
Akira Sobue; Okiru Komine; Fumito Endo; Chihiro Kakimi; Yuka Miyoshi; Noe Kawade; Seiji Watanabe; Yuko Saito; Shigeo Murayama; Takaomi C Saido; Takashi Saito; Koji Yamanaka
Cell death & disease 15 (11) 858 - 858 2024/11 [Refereed]
Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation.Akira Sobue; Okiru Komine; Fumit...See More
Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer's disease mice by controlling astrocyte activation.
Akira Sobue; Okiru Komine; Fumito Endo; Chihiro Kakimi; Yuka Miyoshi; Noe Kawade; Seiji Watanabe; Yuko Saito; Shigeo Murayama; Takaomi C Saido; Takashi Saito; Koji Yamanaka
Cell death & disease 15 (11) 858 - 858 2024/11 [Refereed]

The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.
Sho Shimohama; Ryo Fujioka; Naomi Mihira; Misaki Sekiguchi; Luca Sartori; Daisuke Joho; Takashi Saito; Takaomi C Saido; Jin Nakahara; Tomohito Hino; Atsushi Hoshino; Hiroki Sasaguri
The Journal of neuroscience : the official journal of the Society for Neuroscience 44 (47) 2024/11 [Refereed]
The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.Sho Shimohama; Ryo Fujioka; Naomi Mihira; Misaki Sekiguchi; Luca Sartori; Daisuke Joho; Takashi Saito; Takaomi C Said...See More
The Icelandic Mutation (APP-A673T) Is Protective against Amyloid Pathology In Vivo.
Sho Shimohama; Ryo Fujioka; Naomi Mihira; Misaki Sekiguchi; Luca Sartori; Daisuke Joho; Takashi Saito; Takaomi C Saido; Jin Nakahara; Tomohito Hino; Atsushi Hoshino; Hiroki Sasaguri
The Journal of neuroscience : the official journal of the Society for Neuroscience 44 (47) 2024/11 [Refereed]

GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease.
Kana Sasaki; Hiroki Fujita; Takehiro Sato; Shunske Kato; Yuya Takahashi; Yukio Takeshita; Takashi Kanda; Takashi Saito; Takamori C Saido; Satoko Hattori; Yasukazu Hozumi; Yuichiro Yamada; Hironori Waki
Biochemical and biophysical research communications 741 151016 - 151016 2024/11 [Refereed]
GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease.Kana Sasaki; Hiroki Fujita; Takeh...See More
GLP-1 receptor signaling restores aquaporin 4 subcellular polarization in reactive astrocytes and promotes amyloid β clearance in a mouse model of Alzheimer's disease.
Kana Sasaki; Hiroki Fujita; Takehiro Sato; Shunske Kato; Yuya Takahashi; Yukio Takeshita; Takashi Kanda; Takashi Saito; Takamori C Saido; Satoko Hattori; Yasukazu Hozumi; Yuichiro Yamada; Hironori Waki
Biochemical and biophysical research communications 741 151016 - 151016 2024/11 [Refereed]

Progressive Amyloid-β Accumulation in the Brain leads to Altered Protein Expressions in the Liver and Kidneys of APP knock-in Mice.
Shingo Ito; Yumi Iwata; Mitsumi Otsuka; Yui Kaneko; Seiryo Ogata; Ryotaro Yagi; Tatsuki Uemura; Takeshi Masuda; Takashi Saito; Takaomi Saido; Sumio Ohtsuki
Journal of pharmaceutical sciences 2024/11 [Refereed]
Progressive Amyloid-β Accumulation in the Brain leads to Altered Protein Expressions in the Liver and Kidneys of APP knock-in Mice.Shingo Ito; Yumi Iwata; Mitsumi Otsuka; Yui Kaneko; Seiryo Ogata; Ryo...See More
Progressive Amyloid-β Accumulation in the Brain leads to Altered Protein Expressions in the Liver and Kidneys of APP knock-in Mice.
Shingo Ito; Yumi Iwata; Mitsumi Otsuka; Yui Kaneko; Seiryo Ogata; Ryotaro Yagi; Tatsuki Uemura; Takeshi Masuda; Takashi Saito; Takaomi Saido; Sumio Ohtsuki
Journal of pharmaceutical sciences 2024/11 [Refereed]

Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models.
Stephanie R Miller; Kevin Luxem; Kelli Lauderdale; Pranav Nambiar; Patrick S Honma; Katie K Ly; Shreya Bangera; Mary Bullock; Jia Shin; Nick Kaliss; Yuechen Qiu; Catherine Cai; Kevin Shen; K Dakota Mallen; Zhaoqi Yan; Andrew S Mendiola; Takashi Saito; Takaomi C Saido; Alexander R Pico; Reuben Thomas; Erik D Roberson; Katerina Akassoglou; Pavol Bauer; Stefan Remy; Jorge J Palop
Cell reports 43 (11) 114870 - 114870 2024/10 [Refereed]
Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models.Stephanie R Miller; Kevin Luxem; Kelli Lauderdale; Prana...See More
Machine learning reveals prominent spontaneous behavioral changes and treatment efficacy in humanized and transgenic Alzheimer's disease models.
Stephanie R Miller; Kevin Luxem; Kelli Lauderdale; Pranav Nambiar; Patrick S Honma; Katie K Ly; Shreya Bangera; Mary Bullock; Jia Shin; Nick Kaliss; Yuechen Qiu; Catherine Cai; Kevin Shen; K Dakota Mallen; Zhaoqi Yan; Andrew S Mendiola; Takashi Saito; Takaomi C Saido; Alexander R Pico; Reuben Thomas; Erik D Roberson; Katerina Akassoglou; Pavol Bauer; Stefan Remy; Jorge J Palop
Cell reports 43 (11) 114870 - 114870 2024/10 [Refereed]

Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.
Nicholas Sweeney; Tae Yeon Kim; Cody T Morrison; Liangping Li; Diana Acosta; Jiawen Liang; Nithin V Datla; Julie A Fitzgerald; Haoran Huang; Xianglan Liu; Gregory Huang Tan; Min Wu; Kate Karelina; Chelsea E Bray; Zachary M Weil; Douglas W Scharre; Geidy E Serrano; Takashi Saito; Takaomi C Saido; Thomas G Beach; Olga N Kokiko-Cochran; Jonathan P Godbout; Gail V W Johnson; Hongjun Fu
Acta neuropathologica 148 (1) 52 - 52 2024/10 [Refereed]
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.Nicholas Sweeney; Tae...See More
Neuronal BAG3 attenuates tau hyperphosphorylation, synaptic dysfunction, and cognitive deficits induced by traumatic brain injury via the regulation of autophagy-lysosome pathway.
Nicholas Sweeney; Tae Yeon Kim; Cody T Morrison; Liangping Li; Diana Acosta; Jiawen Liang; Nithin V Datla; Julie A Fitzgerald; Haoran Huang; Xianglan Liu; Gregory Huang Tan; Min Wu; Kate Karelina; Chelsea E Bray; Zachary M Weil; Douglas W Scharre; Geidy E Serrano; Takashi Saito; Takaomi C Saido; Thomas G Beach; Olga N Kokiko-Cochran; Jonathan P Godbout; Gail V W Johnson; Hongjun Fu
Acta neuropathologica 148 (1) 52 - 52 2024/10 [Refereed]

Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab
Nobuhisa Iwata; Satoshi Tsubuki; Misaki Sekiguchi; Kaori Watanabe-Iwata; Yukio Matsuba; Naoko Kamano; Ryo Fujioka; Risa Takamura; Naoto Watamura; Naomasa Kakiya; Naomi Mihira; Takahiro Morito; Keiro Shirotani; David MA Mann; Andrew C Robinson; Shoko Hashimoto; Hiroki Sasaguri; Takashi Saito; Makoto Higuchi; Takaomi C Saido
Life Science Alliance Life Science Alliance, LLC 7 (12) e202402650 - e202402650 2024/09 [Refereed]
Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemabNobuhisa Iwata; Satoshi Tsubuki; Misaki Sekiguchi; Kaori Watanabe-Iwata; Yukio Matsuba; Naoko Ka...See More
Metabolic resistance of Aβ3pE-42, a target epitope of the anti-Alzheimer therapeutic antibody, donanemab
Nobuhisa Iwata; Satoshi Tsubuki; Misaki Sekiguchi; Kaori Watanabe-Iwata; Yukio Matsuba; Naoko Kamano; Ryo Fujioka; Risa Takamura; Naoto Watamura; Naomasa Kakiya; Naomi Mihira; Takahiro Morito; Keiro Shirotani; David MA Mann; Andrew C Robinson; Shoko Hashimoto; Hiroki Sasaguri; Takashi Saito; Makoto Higuchi; Takaomi C Saido
Life Science Alliance Life Science Alliance, LLC 7 (12) e202402650 - e202402650 2024/09 [Refereed]

The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice.
Akira Uruno; Shiori Kadoguchi-Igarashi; Ritsumi Saito; Shohei Koiso; Daisuke Saigusa; Ching-Tung Chu; Takafumi Suzuki; Takashi Saito; Takaomi C Saido; Antonio Cuadrado; Masayuki Yamamoto
Journal of biochemistry 2024/09 [Refereed]
The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice.Akira Uruno; Shiori Kadoguchi-Igarashi; Ritsumi Saito; Shohei Koiso; Daisuke Saigusa; Ching-Tung ...See More
The NRF2 inducer CDDO-2P-Im provokes a reduction in amyloid β levels in Alzheimer's disease model mice.
Akira Uruno; Shiori Kadoguchi-Igarashi; Ritsumi Saito; Shohei Koiso; Daisuke Saigusa; Ching-Tung Chu; Takafumi Suzuki; Takashi Saito; Takaomi C Saido; Antonio Cuadrado; Masayuki Yamamoto
Journal of biochemistry 2024/09 [Refereed]

Cognitive Effects of Simulated Galactic Cosmic Radiation Are Mediated by ApoE Status, Sex, and Environment in APP Knock-In Mice.
Laura Wieg; Jason C Ciola; Caroline C Wasén; Fidelia Gaba; Brianna R Colletti; Maren K Schroeder; Robert G Hinshaw; Millicent N Ekwudo; David M Holtzman; Takashi Saito; Hiroki Sasaguri; Takaomi C Saido; Laura M Cox; Cynthia A Lemere
International journal of molecular sciences 25 (17) 2024/08 [Refereed]
Cognitive Effects of Simulated Galactic Cosmic Radiation Are Mediated by ApoE Status, Sex, and Environment in APP Knock-In Mice.Laura Wieg; Jason C Ciola; Caroline C Wasén; Fidelia Gaba; Brianna R Col...See More
Cognitive Effects of Simulated Galactic Cosmic Radiation Are Mediated by ApoE Status, Sex, and Environment in APP Knock-In Mice.
Laura Wieg; Jason C Ciola; Caroline C Wasén; Fidelia Gaba; Brianna R Colletti; Maren K Schroeder; Robert G Hinshaw; Millicent N Ekwudo; David M Holtzman; Takashi Saito; Hiroki Sasaguri; Takaomi C Saido; Laura M Cox; Cynthia A Lemere
International journal of molecular sciences 25 (17) 2024/08 [Refereed]

Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging.
Keiko Honda; Hiroo Takahashi; Saori Hata; Ruriko Abe; Takashi Saito; Takaomi C Saido; Hidenori Taru; Yuriko Sobu; Kanae Ando; Tohru Yamamoto; Toshiharu Suzuki
Scientific reports 14 (1) 18471 - 18471 2024/08 [Refereed]
Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging.Keiko Honda; Hiroo Takahashi; Saori Hata; Ruriko Abe; Takashi Saito; Takaomi C Sai...See More
Suppression of the amyloidogenic metabolism of APP and the accumulation of Aβ by alcadein α in the brain during aging.
Keiko Honda; Hiroo Takahashi; Saori Hata; Ruriko Abe; Takashi Saito; Takaomi C Saido; Hidenori Taru; Yuriko Sobu; Kanae Ando; Tohru Yamamoto; Toshiharu Suzuki
Scientific reports 14 (1) 18471 - 18471 2024/08 [Refereed]

The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain.
Naoto Watamura; Naomasa Kakiya; Ryo Fujioka; Naoko Kamano; Mika Takahashi; Per Nilsson; Takashi Saito; Nobuhisa Iwata; Shigeyoshi Fujisawa; Takaomi C Saido
Science signaling 17 (848) eadk1822 2024/08 [Refereed]
The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain.Naoto Watamura; Naomasa Kakiya; Ryo Fujioka; Naoko Kamano; Mika Takahashi; Per Nilsson; Takashi Saito; Nobuhi...See More
The dopaminergic system promotes neprilysin-mediated degradation of amyloid-β in the brain.
Naoto Watamura; Naomasa Kakiya; Ryo Fujioka; Naoko Kamano; Mika Takahashi; Per Nilsson; Takashi Saito; Nobuhisa Iwata; Shigeyoshi Fujisawa; Takaomi C Saido
Science signaling 17 (848) eadk1822 2024/08 [Refereed]

Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
Andrew Octavian Sasmita; Constanze Depp; Taisiia Nazarenko; Ting Sun; Sophie B Siems; Erinne Cherisse Ong; Yakum B Nkeh; Carolin Böhler; Xuan Yu; Bastian Bues; Lisa Evangelista; Shuying Mao; Barbara Morgado; Zoe Wu; Torben Ruhwedel; Swati Subramanian; Friederike Börensen; Katharina Overhoff; Lena Spieth; Stefan A Berghoff; Katherine Rose Sadleir; Robert Vassar; Simone Eggert; Sandra Goebbels; Takashi Saito; Takaomi Saido; Gesine Saher; Wiebke Möbius; Gonçalo Castelo-Branco; Hans-Wolfgang Klafki; Oliver Wirths; Jens Wiltfang; Sarah Jäkel; Riqiang Yan; Klaus-Armin Nave
Nature neuroscience 2024/08 [Refereed]
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.Andrew Octavian Sasmita; Constanze Depp; Taisiia Nazarenko; Ting Sun; Sophie B...See More
Oligodendrocytes produce amyloid-β and contribute to plaque formation alongside neurons in Alzheimer's disease model mice.
Andrew Octavian Sasmita; Constanze Depp; Taisiia Nazarenko; Ting Sun; Sophie B Siems; Erinne Cherisse Ong; Yakum B Nkeh; Carolin Böhler; Xuan Yu; Bastian Bues; Lisa Evangelista; Shuying Mao; Barbara Morgado; Zoe Wu; Torben Ruhwedel; Swati Subramanian; Friederike Börensen; Katharina Overhoff; Lena Spieth; Stefan A Berghoff; Katherine Rose Sadleir; Robert Vassar; Simone Eggert; Sandra Goebbels; Takashi Saito; Takaomi Saido; Gesine Saher; Wiebke Möbius; Gonçalo Castelo-Branco; Hans-Wolfgang Klafki; Oliver Wirths; Jens Wiltfang; Sarah Jäkel; Riqiang Yan; Klaus-Armin Nave
Nature neuroscience 2024/08 [Refereed]

Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer's Disease.
Lidia Sánchez-Puebla; Rosa de Hoz; Elena Salobrar-García; Alberto Arias-Vázquez; María González-Jiménez; Ana I Ramírez; José A Fernández-Albarral; José A Matamoros; Lorena Elvira-Hurtado; Takaomi C Saido; Takashi Saito; Carmen Nieto Vaquero; María I Cuartero; María A Moro; Juan J Salazar; Inés López-Cuenca; José M Ramírez
International journal of molecular sciences 25 (15) 2024/07 [Refereed]
Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer's Disease.Lidia Sánchez-Puebla; Rosa de Hoz; Elena Salobrar-García; Alberto Arias-Vázquez; ...See More
Age-Related Retinal Layer Thickness Changes Measured by OCT in APPNL-F/NL-F Mice: Implications for Alzheimer's Disease.
Lidia Sánchez-Puebla; Rosa de Hoz; Elena Salobrar-García; Alberto Arias-Vázquez; María González-Jiménez; Ana I Ramírez; José A Fernández-Albarral; José A Matamoros; Lorena Elvira-Hurtado; Takaomi C Saido; Takashi Saito; Carmen Nieto Vaquero; María I Cuartero; María A Moro; Juan J Salazar; Inés López-Cuenca; José M Ramírez
International journal of molecular sciences 25 (15) 2024/07 [Refereed]

Retinal Vascular and Structural Changes in the Murine Alzheimer's APPNL-F/NL-F Model from 6 to 20 Months.
Lidia Sánchez-Puebla; Inés López-Cuenca; Elena Salobrar-García; María González-Jiménez; Alberto Arias-Vázquez; José A Matamoros; Ana I Ramírez; José A Fernández-Albarral; Lorena Elvira-Hurtado; Takaomi C Saido; Takashi Saito; Carmen Nieto-Vaquero; María I Cuartero; María A Moro; Juan J Salazar; Rosa de Hoz; José M Ramírez
Biomolecules 14 (7) 2024/07 [Refereed]
Retinal Vascular and Structural Changes in the Murine Alzheimer's APPNL-F/NL-F Model from 6 to 20 Months.Lidia Sánchez-Puebla; Inés López-Cuenca; Elena Salobrar-García; María González-Jiménez; Alberto...See More
Retinal Vascular and Structural Changes in the Murine Alzheimer's APPNL-F/NL-F Model from 6 to 20 Months.
Lidia Sánchez-Puebla; Inés López-Cuenca; Elena Salobrar-García; María González-Jiménez; Alberto Arias-Vázquez; José A Matamoros; Ana I Ramírez; José A Fernández-Albarral; Lorena Elvira-Hurtado; Takaomi C Saido; Takashi Saito; Carmen Nieto-Vaquero; María I Cuartero; María A Moro; Juan J Salazar; Rosa de Hoz; José M Ramírez
Biomolecules 14 (7) 2024/07 [Refereed]

Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice.
Ryo Inagaki; Tohru Yamakuni; Takashi Saito; Takaomi C Saido; Shigeki Moriguchi
Neurobiology of aging 139 20 - 29 2024/07 [Refereed]
Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice.Ryo Inagaki; Tohru Yamakuni; Takashi Saito; Takaomi C Saido; Shigeki MoriguchiNeurobiology of aging 139 20 - 29 202...See More
Preventive effect of propolis on cognitive decline in Alzheimer's disease model mice.
Ryo Inagaki; Tohru Yamakuni; Takashi Saito; Takaomi C Saido; Shigeki Moriguchi
Neurobiology of aging 139 20 - 29 2024/07 [Refereed]

Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice.
Farjana Parvin; Samuel Haglund; Bettina Wegenast-Braun; Mathias Jucker; Takashi Saito; Takaomi C Saido; K Peter R Nilsson; Per Nilsson; Sofie Nyström; Per Hammarström
ACS chemical neuroscience 15 (10) 2058 - 2069 2024/05 [Refereed]
Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice.Farjana Parvin; Samuel Haglund; Bettina Wegenast-Braun; Mathias Jucker; Takashi Saito...See More
Divergent Age-Dependent Conformational Rearrangement within Aβ Amyloid Deposits in APP23, APPPS1, and AppNL-F Mice.
Farjana Parvin; Samuel Haglund; Bettina Wegenast-Braun; Mathias Jucker; Takashi Saito; Takaomi C Saido; K Peter R Nilsson; Per Nilsson; Sofie Nyström; Per Hammarström
ACS chemical neuroscience 15 (10) 2058 - 2069 2024/05 [Refereed]

Effects of tooth loss on behavioral and psychological symptoms of dementia in app knock-in mice.
Masae Furukawa; Hirobumi Tada; Resmi Raju; Jingshu Wang; Haruna Yokoi; Mitsuyoshi Yamada; Yosuke Shikama; Takashi Saito; Takaomi C Saido; Kenji Matsushita
Journal of oral biosciences 2024/03 [Refereed]
Effects of tooth loss on behavioral and psychological symptoms of dementia in app knock-in mice.Masae Furukawa; Hirobumi Tada; Resmi Raju; Jingshu Wang; Haruna Yokoi; Mitsuyoshi Yamada; Yosuke Shikama...See More
Effects of tooth loss on behavioral and psychological symptoms of dementia in app knock-in mice.
Masae Furukawa; Hirobumi Tada; Resmi Raju; Jingshu Wang; Haruna Yokoi; Mitsuyoshi Yamada; Yosuke Shikama; Takashi Saito; Takaomi C Saido; Kenji Matsushita
Journal of oral biosciences 2024/03 [Refereed]

Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation.
Takeru Nagayama; Sosuke Yagishita; Megumi Shibata; Akiko Furuno; Takashi Saito; Takaomi C Saido; Shuji Wakatsuki; Toshiyuki Araki
Neuroscience research 2024/03 [Refereed]
Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation.Takeru Nagayama; Sosuke Yagishita; Megumi Shibata; Akiko Furuno; Takashi Saito; Takaomi C Sa...See More
Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation.
Takeru Nagayama; Sosuke Yagishita; Megumi Shibata; Akiko Furuno; Takashi Saito; Takaomi C Saido; Shuji Wakatsuki; Toshiyuki Araki
Neuroscience research 2024/03 [Refereed]

Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease.
Ting Wang; Akira Sobue; Seiji Watanabe; Okiru Komine; Takaomi C Saido; Takashi Saito; Koji Yamanaka
Journal of neuroinflammation 21 (1) 55 - 55 2024/02 [Refereed]
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease.Ting Wang; Akira Sobue; Seiji Watanabe; Okiru Komine; Takaomi C Saido; Takashi Saito; Koji Yamana...See More
Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer's disease.
Ting Wang; Akira Sobue; Seiji Watanabe; Okiru Komine; Takaomi C Saido; Takashi Saito; Koji Yamanaka
Journal of neuroinflammation 21 (1) 55 - 55 2024/02 [Refereed]

Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains.
Helen Xuexia Huang; Paolo Inglese; Jiabin Tang; Riad Yagoubi; Gonçalo D S Correia; Verena M Horneffer-van der Sluis; Stephane Camuzeaux; Vincen Wu; Maksym V Kopanitsa; Nanet Willumsen; Johanna S Jackson; Anna M Barron; Takashi Saito; Takaomi C Saido; Steve Gentlemen; Zoltan Takats; Paul M Matthews
Journal of neurochemistry 2024/02 [Refereed]
Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains.Helen Xuexia Huang; Paolo Inglese; Jiabin Tang; Riad Yagoubi; Gonçalo D S Correia...See More
Mass spectrometry imaging highlights dynamic patterns of lipid co-expression with Aβ plaques in mouse and human brains.
Helen Xuexia Huang; Paolo Inglese; Jiabin Tang; Riad Yagoubi; Gonçalo D S Correia; Verena M Horneffer-van der Sluis; Stephane Camuzeaux; Vincen Wu; Maksym V Kopanitsa; Nanet Willumsen; Johanna S Jackson; Anna M Barron; Takashi Saito; Takaomi C Saido; Steve Gentlemen; Zoltan Takats; Paul M Matthews
Journal of neurochemistry 2024/02 [Refereed]

Temporal alterations in white matter in an App knock-in mouse model of Alzheimer's disease.
Zachery D Morrissey; Jin Gao; Aashutosh Shetti; Wenping Li; Liang Zhan; Weiguo Li; Igor Fortel; Takaomi Saido; Takashi Saito; Olusola Ajilore; Stephanie M Cologna; Orly Lazarov; Alex D Leow
eNeuro 2024/01 [Refereed]
Temporal alterations in white matter in an App knock-in mouse model of Alzheimer's disease.Zachery D Morrissey; Jin Gao; Aashutosh Shetti; Wenping Li; Liang Zhan; Weiguo Li; Igor Fortel; Takaomi Saido...See More
Temporal alterations in white matter in an App knock-in mouse model of Alzheimer's disease.
Zachery D Morrissey; Jin Gao; Aashutosh Shetti; Wenping Li; Liang Zhan; Weiguo Li; Igor Fortel; Takaomi Saido; Takashi Saito; Olusola Ajilore; Stephanie M Cologna; Orly Lazarov; Alex D Leow
eNeuro 2024/01 [Refereed]

β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer's disease.
Lulu Jiang; Rebecca Roberts; Melissa Wong; Lushuang Zhang; Chelsea Joy Webber; Jenna Libera; Zihan Wang; Alper Kilci; Matthew Jenkins; Alejandro Rondón Ortiz; Luke Dorrian; Jingjing Sun; Guangxin Sun; Sherif Rashad; Caroline Kornbrek; Sarah Anne Daley; Peter C Dedon; Brian Nguyen; Weiming Xia; Takashi Saito; Takaomi C Saido; Benjamin Wolozin
Frontiers in neuroscience 18 1372297 - 1372297 2024 [Refereed]
β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer's disease.Lulu Jiang; Rebecca Roberts; Melissa Wong; Lushuang Zhang; Che...See More
β-amyloid accumulation enhances microtubule associated protein tau pathology in an APPNL-G-F/MAPTP301S mouse model of Alzheimer's disease.
Lulu Jiang; Rebecca Roberts; Melissa Wong; Lushuang Zhang; Chelsea Joy Webber; Jenna Libera; Zihan Wang; Alper Kilci; Matthew Jenkins; Alejandro Rondón Ortiz; Luke Dorrian; Jingjing Sun; Guangxin Sun; Sherif Rashad; Caroline Kornbrek; Sarah Anne Daley; Peter C Dedon; Brian Nguyen; Weiming Xia; Takashi Saito; Takaomi C Saido; Benjamin Wolozin
Frontiers in neuroscience 18 1372297 - 1372297 2024 [Refereed]

Disturbance in the protein landscape of cochlear perilymph in an Alzheimer's disease mouse model.
Masatoshi Fukuda; Hiroki Okanishi; Daisuke Ino; Kazuya Ono; Satoru Kawamura; Eri Wakai; Tsuyoshi Miyoshi; Takashi Sato; Yumi Ohta; Takashi Saito; Takaomi C Saido; Hidenori Inohara; Yoshikatsu Kanai; Hiroshi Hibino
PloS one 19 (5) e0303375 2024 [Refereed]
Disturbance in the protein landscape of cochlear perilymph in an Alzheimer's disease mouse model.Masatoshi Fukuda; Hiroki Okanishi; Daisuke Ino; Kazuya Ono; Satoru Kawamura; Eri Wakai; Tsuyoshi Miyosh...See More
Disturbance in the protein landscape of cochlear perilymph in an Alzheimer's disease mouse model.
Masatoshi Fukuda; Hiroki Okanishi; Daisuke Ino; Kazuya Ono; Satoru Kawamura; Eri Wakai; Tsuyoshi Miyoshi; Takashi Sato; Yumi Ohta; Takashi Saito; Takaomi C Saido; Hidenori Inohara; Yoshikatsu Kanai; Hiroshi Hibino
PloS one 19 (5) e0303375 2024 [Refereed]

Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer's disease in adult Alzheimer's model AppNL-G-F mice.
Suzuko Ochi; Kumiko Yamada; Takashi Saito; Takaomi C Saido; Mitsuo Iinuma; Kagaku Azuma; Kin-Ya Kubo
Frontiers in aging neuroscience 16 1361847 - 1361847 2024 [Refereed]
Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer's disease in adult Alzheimer's model AppNL-G-F mice.Suzuko Ochi; Kumiko Yamada; Takashi Saito; Takaomi C...See More
Effects of early tooth loss on chronic stress and progression of neuropathogenesis of Alzheimer's disease in adult Alzheimer's model AppNL-G-F mice.
Suzuko Ochi; Kumiko Yamada; Takashi Saito; Takaomi C Saido; Mitsuo Iinuma; Kagaku Azuma; Kin-Ya Kubo
Frontiers in aging neuroscience 16 1361847 - 1361847 2024 [Refereed]

Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease.
Sahana Srinivasan; Daliya Kancheva; Sofie De Ren; Takashi Saito; Maude Jans; Fleur Boone; Charysse Vandendriessche; Ine Paesmans; Hervé Maurin; Roosmarijn E Vandenbroucke; Esther Hoste; Sofie Voet; Isabelle Scheyltjens; Benjamin Pavie; Saskia Lippens; Marius Schwabenland; Marco Prinz; Takaomi Saido; Astrid Bottelbergs; Kiavash Movahedi; Mohamed Lamkanfi; Geert van Loo
Frontiers in immunology 15 1323409 - 1323409 2024 [Refereed]
Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease.Sahana Srinivasan; Daliya Kancheva; Sofie De Ren; Takashi Saito; Maude Jans; Fle...See More
Inflammasome signaling is dispensable for ß-amyloid-induced neuropathology in preclinical models of Alzheimer's disease.
Sahana Srinivasan; Daliya Kancheva; Sofie De Ren; Takashi Saito; Maude Jans; Fleur Boone; Charysse Vandendriessche; Ine Paesmans; Hervé Maurin; Roosmarijn E Vandenbroucke; Esther Hoste; Sofie Voet; Isabelle Scheyltjens; Benjamin Pavie; Saskia Lippens; Marius Schwabenland; Marco Prinz; Takaomi Saido; Astrid Bottelbergs; Kiavash Movahedi; Mohamed Lamkanfi; Geert van Loo
Frontiers in immunology 15 1323409 - 1323409 2024 [Refereed]

Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease.
Michael J D Daniels; Lucas Lefevre; Stefan Szymkowiak; Alice Drake; Laura McCulloch; Makis Tzioras; Jack Barrington; Owen R Dando; Xin He; Mehreen Mohammad; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Tara L Spires-Jones; Barry W McColl
eLife 12 2023/12 [Refereed]
Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease.Michael J D Daniels; Lucas Lefevre; Stefan Szymkowiak; Alice Drake; Laura McCulloch; Makis...See More
Cystatin F (Cst7) drives sex-dependent changes in microglia in an amyloid-driven model of Alzheimer's disease.
Michael J D Daniels; Lucas Lefevre; Stefan Szymkowiak; Alice Drake; Laura McCulloch; Makis Tzioras; Jack Barrington; Owen R Dando; Xin He; Mehreen Mohammad; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Tara L Spires-Jones; Barry W McColl
eLife 12 2023/12 [Refereed]

Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease.
Naotaka Izuo; Nobuhiro Watanabe; Yoshihiro Noda; Takashi Saito; Takaomi C Saido; Koutaro Yokote; Harumi Hotta; Takahiko Shimizu
Aging cell 22 (11) e13994 2023/11 [Refereed]
Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease.Naotaka Izuo; Nobuhiro Watanabe; Yoshihiro Noda; Tak...See More
Insulin resistance induces earlier initiation of cognitive dysfunction mediated by cholinergic deregulation in a mouse model of Alzheimer's disease.
Naotaka Izuo; Nobuhiro Watanabe; Yoshihiro Noda; Takashi Saito; Takaomi C Saido; Koutaro Yokote; Harumi Hotta; Takahiko Shimizu
Aging cell 22 (11) e13994 2023/11 [Refereed]

Sex-dependent cholinergic effects on amyloid pathology: A translational study.
Liliana German-Castelan; Hayley R C Shanks; Robert Gros; Takashi Saito; Takaomi C Saido; Lisa M Saksida; Timothy J Bussey; Marco A M Prado; Taylor W Schmitz; Vania F Prado
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023/10 [Refereed]
Sex-dependent cholinergic effects on amyloid pathology: A translational study.Liliana German-Castelan; Hayley R C Shanks; Robert Gros; Takashi Saito; Takaomi C Saido; Lisa M Saksida; Timothy J Bussey;...See More
Sex-dependent cholinergic effects on amyloid pathology: A translational study.
Liliana German-Castelan; Hayley R C Shanks; Robert Gros; Takashi Saito; Takaomi C Saido; Lisa M Saksida; Timothy J Bussey; Marco A M Prado; Taylor W Schmitz; Vania F Prado
Alzheimer's & dementia : the journal of the Alzheimer's Association 2023/10 [Refereed]

Proteomic alterations in the brain and blood-brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer's disease.
Shingo Ito; Ryotaro Yagi; Seiryo Ogata; Takeshi Masuda; Takashi Saito; Takaomi Saido; Sumio Ohtsuki
Fluids and barriers of the CNS 20 (1) 66 - 66 2023/09 [Refereed]
Proteomic alterations in the brain and blood-brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer's disease.Shingo Ito; Ryotaro Yagi; Seiryo Ogata; Takeshi Masuda; Ta...See More
Proteomic alterations in the brain and blood-brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer's disease.
Shingo Ito; Ryotaro Yagi; Seiryo Ogata; Takeshi Masuda; Takashi Saito; Takaomi Saido; Sumio Ohtsuki
Fluids and barriers of the CNS 20 (1) 66 - 66 2023/09 [Refereed]

A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury.
Xinyi Zhao; Wen Zeng; Hong Xu; Zihan Sun; Yingxin Hu; Beibei Peng; Jennifer D McBride; Jiangtao Duan; Juan Deng; Bin Zhang; Soo-Jung Kim; Bryan Zoll; Takashi Saito; Hiroki Sasaguri; Takaomi C Saido; Carlo Ballatore; Haishan Yao; Zhaoyin Wang; John Q Trojanowski; Kurt R Brunden; Virginia M-Y Lee; Zhuohao He
Science translational medicine 15 (713) eabo6889 2023/09 [Refereed]
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury.Xinyi Zhao; Wen Zeng; Hong Xu; Zihan Sun; Yingxin Hu; Beibei Peng; ...See More
A microtubule stabilizer ameliorates protein pathogenesis and neurodegeneration in mouse models of repetitive traumatic brain injury.
Xinyi Zhao; Wen Zeng; Hong Xu; Zihan Sun; Yingxin Hu; Beibei Peng; Jennifer D McBride; Jiangtao Duan; Juan Deng; Bin Zhang; Soo-Jung Kim; Bryan Zoll; Takashi Saito; Hiroki Sasaguri; Takaomi C Saido; Carlo Ballatore; Haishan Yao; Zhaoyin Wang; John Q Trojanowski; Kurt R Brunden; Virginia M-Y Lee; Zhuohao He
Science translational medicine 15 (713) eabo6889 2023/09 [Refereed]

Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Erik Nutma; Nurun Fancy; Maria Weinert; Stergios Tsartsalis; Manuel C Marzin; Robert C J Muirhead; Irene Falk; Marjolein Breur; Joy de Bruin; David Hollaus; Robin Pieterman; Jasper Anink; David Story; Siddharthan Chandran; Jiabin Tang; Maria C Trolese; Takashi Saito; Takaomi C Saido; Katharine H Wiltshire; Paula Beltran-Lobo; Alexandra Phillips; Jack Antel; Luke Healy; Marie-France Dorion; Dylan A Galloway; Rochelle Y Benoit; Quentin Amossé; Kelly Ceyzériat; Aurélien M Badina; Enikö Kövari; Caterina Bendotti; Eleonora Aronica; Carola I Radulescu; Jia Hui Wong; Anna M Barron; Amy M Smith; Samuel J Barnes; David W Hampton; Paul van der Valk; Steven Jacobson; Owain W Howell; David Baker; Markus Kipp; Hannes Kaddatz; Benjamin B Tournier; Philippe Millet; Paul M Matthews; Craig S Moore; Sandra Amor; David R Owen
Nature communications 14 (1) 5247 - 5247 2023/08 [Refereed]
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.Erik Nutma; Nurun Fancy; Maria Weinert; Stergios Tsartsalis; Manuel C Marzin; Robert C...See More
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Erik Nutma; Nurun Fancy; Maria Weinert; Stergios Tsartsalis; Manuel C Marzin; Robert C J Muirhead; Irene Falk; Marjolein Breur; Joy de Bruin; David Hollaus; Robin Pieterman; Jasper Anink; David Story; Siddharthan Chandran; Jiabin Tang; Maria C Trolese; Takashi Saito; Takaomi C Saido; Katharine H Wiltshire; Paula Beltran-Lobo; Alexandra Phillips; Jack Antel; Luke Healy; Marie-France Dorion; Dylan A Galloway; Rochelle Y Benoit; Quentin Amossé; Kelly Ceyzériat; Aurélien M Badina; Enikö Kövari; Caterina Bendotti; Eleonora Aronica; Carola I Radulescu; Jia Hui Wong; Anna M Barron; Amy M Smith; Samuel J Barnes; David W Hampton; Paul van der Valk; Steven Jacobson; Owain W Howell; David Baker; Markus Kipp; Hannes Kaddatz; Benjamin B Tournier; Philippe Millet; Paul M Matthews; Craig S Moore; Sandra Amor; David R Owen
Nature communications 14 (1) 5247 - 5247 2023/08 [Refereed]

A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.
Hinze Ho; Nejc Kejzar; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Bart De Strooper; Marius Bauza; Julija Krupic
Cell reports methods 3 (7) 100532 - 100532 2023/07 [Refereed]
A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.Hinze Ho; Nejc Kejzar; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Bart De Strooper; Marius Bauza;...See More
A fully automated home cage for long-term continuous phenotyping of mouse cognition and behavior.
Hinze Ho; Nejc Kejzar; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Bart De Strooper; Marius Bauza; Julija Krupic
Cell reports methods 3 (7) 100532 - 100532 2023/07 [Refereed]

Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease.
Ewa Trojan; Katarzyna Curzytek; Paulina Cieślik; Joanna M Wierońska; Johannes Graff; Władysław Lasoń; Takashi Saito; Takaomi C Saido; Agnieszka Basta-Kaim
Neurobiology of disease 184 106219 - 106219 2023/07 [Refereed]
Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease.Ewa Trojan; Katarzyn...See More
Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease.
Ewa Trojan; Katarzyna Curzytek; Paulina Cieślik; Joanna M Wierońska; Johannes Graff; Władysław Lasoń; Takashi Saito; Takaomi C Saido; Agnieszka Basta-Kaim
Neurobiology of disease 184 106219 - 106219 2023/07 [Refereed]

Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal - medial prefrontal cortex circuit during natural sleep in AppNL-G-F/NL-G-F mice.
Erica S Brady; Jessica Griffiths; Lilya Andrianova; Monika H Bielska; Takashi Saito; Takaomi C Saido; Andrew D Randall; Francesco Tamagnini; Jonathan Witton; Michael T Craig
Neurobiology of disease 182 106151 - 106151 2023/06 [Refereed]
Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal - medial prefrontal cortex circuit during natural sleep in AppNL-G-F/NL-G-F mice.Erica...See More
Alterations to parvalbumin-expressing interneuron function and associated network oscillations in the hippocampal - medial prefrontal cortex circuit during natural sleep in AppNL-G-F/NL-G-F mice.
Erica S Brady; Jessica Griffiths; Lilya Andrianova; Monika H Bielska; Takashi Saito; Takaomi C Saido; Andrew D Randall; Francesco Tamagnini; Jonathan Witton; Michael T Craig
Neurobiology of disease 182 106151 - 106151 2023/06 [Refereed]

Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.
Constanze Depp; Ting Sun; Andrew Octavian Sasmita; Lena Spieth; Stefan A Berghoff; Taisiia Nazarenko; Katharina Overhoff; Agnes A Steixner-Kumar; Swati Subramanian; Sahab Arinrad; Torben Ruhwedel; Wiebke Möbius; Sandra Göbbels; Gesine Saher; Hauke B Werner; Alkmini Damkou; Silvia Zampar; Oliver Wirths; Maik Thalmann; Mikael Simons; Takashi Saito; Takaomi Saido; Dilja Krueger-Burg; Riki Kawaguchi; Michael Willem; Christian Haass; Daniel Geschwind; Hannelore Ehrenreich; Ruth Stassart; Klaus-Armin Nave
Nature 618 (7964) 349 - 357 2023/06 [Refereed]
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.Constanze Depp; Ting Sun; Andrew Octavian Sasmita; Lena Spieth; Stefan A Berghoff; Taisiia Nazarenko; Katharina Overhoff...See More
Myelin dysfunction drives amyloid-β deposition in models of Alzheimer's disease.
Constanze Depp; Ting Sun; Andrew Octavian Sasmita; Lena Spieth; Stefan A Berghoff; Taisiia Nazarenko; Katharina Overhoff; Agnes A Steixner-Kumar; Swati Subramanian; Sahab Arinrad; Torben Ruhwedel; Wiebke Möbius; Sandra Göbbels; Gesine Saher; Hauke B Werner; Alkmini Damkou; Silvia Zampar; Oliver Wirths; Maik Thalmann; Mikael Simons; Takashi Saito; Takaomi Saido; Dilja Krueger-Burg; Riki Kawaguchi; Michael Willem; Christian Haass; Daniel Geschwind; Hannelore Ehrenreich; Ruth Stassart; Klaus-Armin Nave
Nature 618 (7964) 349 - 357 2023/06 [Refereed]

Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer's disease-like neuropathology in the AppNL-G-F knock-in mouse model.
Jason G Kilian; Marina Mejias-Ortega; Heng-Wei Hsu; David A Herman; Janielle Vidal; Rebecca J Arechavala; Samantha Renusch; Hansal Dalal; Irene Hasen; Amanda Ting; Carlos J Rodriguez-Ortiz; Siok-Lam Lim; Xiaomeng Lin; Joan Vu; Takashi Saito; Takaomi C Saido; Michael T Kleinman; Masashi Kitazawa
Toxicological sciences : an official journal of the Society of Toxicology 193 (2) 175 - 191 2023/05 [Refereed]
Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer's disease-like neuropathology in the AppNL-G-F knock-in mouse model.Jason G Kilian; Marina Mejias-Ortega; Hen...See More
Exposure to quasi-ultrafine particulate matter accelerates memory impairment and Alzheimer's disease-like neuropathology in the AppNL-G-F knock-in mouse model.
Jason G Kilian; Marina Mejias-Ortega; Heng-Wei Hsu; David A Herman; Janielle Vidal; Rebecca J Arechavala; Samantha Renusch; Hansal Dalal; Irene Hasen; Amanda Ting; Carlos J Rodriguez-Ortiz; Siok-Lam Lim; Xiaomeng Lin; Joan Vu; Takashi Saito; Takaomi C Saido; Michael T Kleinman; Masashi Kitazawa
Toxicological sciences : an official journal of the Society of Toxicology 193 (2) 175 - 191 2023/05 [Refereed]

INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.
Akihiro Iguchi; Sho Takatori; Shingo Kimura; Hiroki Muneto; Kai Wang; Hayato Etani; Genta Ito; Haruaki Sato; Yukiko Hori; Junko Sasaki; Takashi Saito; Takaomi C Saido; Tsuneya Ikezu; Toshiyuki Takai; Takehiko Sasaki; Taisuke Tomita
iScience 26 (4) 106375 - 106375 2023/04 [Refereed]
INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.Akihiro Iguchi; Sho Takatori; Shingo Kimura; Hiroki Muneto; Kai Wang; Hayato Etani; Genta Ito; Haruaki Sato; Yukiko Ho...See More
INPP5D modulates TREM2 loss-of-function phenotypes in a β-amyloidosis mouse model.
Akihiro Iguchi; Sho Takatori; Shingo Kimura; Hiroki Muneto; Kai Wang; Hayato Etani; Genta Ito; Haruaki Sato; Yukiko Hori; Junko Sasaki; Takashi Saito; Takaomi C Saido; Tsuneya Ikezu; Toshiyuki Takai; Takehiko Sasaki; Taisuke Tomita
iScience 26 (4) 106375 - 106375 2023/04 [Refereed]

A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation.
Waka Sato; Miho Watanabe-Takahashi; Takuya Murata; Naoko Utsunomiya-Tate; Jun Motoyama; Masataka Anzai; Seiko Ishihara; Nanako Nishioka; Hina Uchiyama; Juri Togashi; Saeka Nishihara; Kiyoshi Kawasaki; Takashi Saito; Takaomi C Saido; Satoru Funamoto; Kiyotaka Nishikawa
Communications biology 6 (1) 383 - 383 2023/04 [Refereed]
A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation.Waka Sato; Miho Watanabe-Takahashi; Takuya Murata; Naoko Utsunomiya-Tate; Jun Motoyama; Masataka ...See More
A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation.
Waka Sato; Miho Watanabe-Takahashi; Takuya Murata; Naoko Utsunomiya-Tate; Jun Motoyama; Masataka Anzai; Seiko Ishihara; Nanako Nishioka; Hina Uchiyama; Juri Togashi; Saeka Nishihara; Kiyoshi Kawasaki; Takashi Saito; Takaomi C Saido; Satoru Funamoto; Kiyotaka Nishikawa
Communications biology 6 (1) 383 - 383 2023/04 [Refereed]

Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide.
Saori Hata; Haruka Saito; Takeharu Kakiuchi; Dai Fukumoto; Shigeyuki Yamamoto; Kensaku Kasuga; Ayano Kimura; Koichi Moteki; Ruriko Abe; Shungo Adachi; Shoich Kinoshita; Kumiko Yoshizawa-Kumagaye; Hideki Nishio; Takashi Saito; Takaomi C Saido; Tohru Yamamoto; Masaki Nishimura; Hidenori Taru; Yuriko Sobu; Hiroyuki Ohba; Shingo Nishiyama; Norihiro Harada; Takeshi Ikeuchi; Hideo Tsukada; Yasuomi Ouchi; Toshiharu Suzuki
EMBO molecular medicine 15 (5) e17052 2023/03 [Refereed]
Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide.Saori Hata; Haruka Saito; Takeharu Kakiuchi; Dai Fukumoto; Shigeyuki Yamamoto; Kensaku Kasuga; Ayano Kimura;...See More
Brain p3-Alcβ peptide restores neuronal viability impaired by Alzheimer's amyloid β-peptide.
Saori Hata; Haruka Saito; Takeharu Kakiuchi; Dai Fukumoto; Shigeyuki Yamamoto; Kensaku Kasuga; Ayano Kimura; Koichi Moteki; Ruriko Abe; Shungo Adachi; Shoich Kinoshita; Kumiko Yoshizawa-Kumagaye; Hideki Nishio; Takashi Saito; Takaomi C Saido; Tohru Yamamoto; Masaki Nishimura; Hidenori Taru; Yuriko Sobu; Hiroyuki Ohba; Shingo Nishiyama; Norihiro Harada; Takeshi Ikeuchi; Hideo Tsukada; Yasuomi Ouchi; Toshiharu Suzuki
EMBO molecular medicine 15 (5) e17052 2023/03 [Refereed]

Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL-F/NL-F knock-in mouse model of Alzheimer's disease.
Emelie Andersson; Nina Schultz; Takashi Saito; Takaomi C Saido; Kaj Blennow; Gunnar K Gouras; Henrik Zetterberg; Oskar Hansson
Alzheimer's research & therapy 15 (1) 64 - 64 2023/03 [Refereed]
Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL-F/NL-F knock-in mouse model of Alzheimer's disease.Emelie Andersson; Nina Schultz; Takashi Saito; Ta...See More
Cerebral Aβ deposition precedes reduced cerebrospinal fluid and serum Aβ42/Aβ40 ratios in the AppNL-F/NL-F knock-in mouse model of Alzheimer's disease.
Emelie Andersson; Nina Schultz; Takashi Saito; Takaomi C Saido; Kaj Blennow; Gunnar K Gouras; Henrik Zetterberg; Oskar Hansson
Alzheimer's research & therapy 15 (1) 64 - 64 2023/03 [Refereed]

Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease.
Ryusei Kaneko; Ako Matsui; Mahiro Watanabe; Yoshihiro Harada; Mitsuhiro Kanamori; Natsumi Awata; Mio Kawazoe; Tomoaki Takao; Yutaro Kobayashi; Chie Kikutake; Mikita Suyama; Takashi Saito; Takaomi C Saido; Minako Ito
Inflammation and regeneration 43 (1) 20 - 20 2023/03 [Refereed]
Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease.Ryusei Kaneko; Ako Matsui; Mahiro Watanabe; Yoshihiro Harad...See More
Increased neutrophils in inflammatory bowel disease accelerate the accumulation of amyloid plaques in the mouse model of Alzheimer's disease.
Ryusei Kaneko; Ako Matsui; Mahiro Watanabe; Yoshihiro Harada; Mitsuhiro Kanamori; Natsumi Awata; Mio Kawazoe; Tomoaki Takao; Yutaro Kobayashi; Chie Kikutake; Mikita Suyama; Takashi Saito; Takaomi C Saido; Minako Ito
Inflammation and regeneration 43 (1) 20 - 20 2023/03 [Refereed]

The senile plaque: Morphological differences in APP knock-in mice brains by fixatives.
Rikuya Yoshimura; Tomohiro Miyasaka; Satoru Funamoto; Takashi Saito; Takaomi C Saido; Masaya Ikegawa; Nobuto Kakuda
Brain and behavior e2953 2023/03 [Refereed]
The senile plaque: Morphological differences in APP knock-in mice brains by fixatives.Rikuya Yoshimura; Tomohiro Miyasaka; Satoru Funamoto; Takashi Saito; Takaomi C Saido; Masaya Ikegawa; Nobuto Kakud...See More
The senile plaque: Morphological differences in APP knock-in mice brains by fixatives.
Rikuya Yoshimura; Tomohiro Miyasaka; Satoru Funamoto; Takashi Saito; Takaomi C Saido; Masaya Ikegawa; Nobuto Kakuda
Brain and behavior e2953 2023/03 [Refereed]

Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.
Keiko Honda; Yuhki Saito; Haruka Saito; Megumi Toyoda; Ruriko Abe; Takashi Saito; Takaomi C Saido; Makoto Michikawa; Hidenori Taru; Yuriko Sobu; Saori Hata; Tadashi Nakaya; Toshiharu Suzuki
Neurobiology of aging 123 63 - 74 2023/03 [Refereed]
Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.Keiko Honda; Yuhki Saito; Haruk...See More
Accumulation of amyloid-β in the brain of mouse models of Alzheimer's disease is modified by altered gene expression in the presence of human apoE isoforms during aging.
Keiko Honda; Yuhki Saito; Haruka Saito; Megumi Toyoda; Ruriko Abe; Takashi Saito; Takaomi C Saido; Makoto Michikawa; Hidenori Taru; Yuriko Sobu; Saori Hata; Tadashi Nakaya; Toshiharu Suzuki
Neurobiology of aging 123 63 - 74 2023/03 [Refereed]

Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice.
Hanseul Park; Byounggook Cho; Hongwon Kim; Takashi Saito; Takaomi C Saido; Kyoung-Jae Won; Jongpil Kim
Nature communications 14 (1) 802 - 802 2023/02 [Refereed]
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice.Hanseul Park; Byounggook Cho; Hongwon Kim; Takashi Saito; Takaomi C Saido; Kyoung-Jae Won; J...See More
Single-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice.
Hanseul Park; Byounggook Cho; Hongwon Kim; Takashi Saito; Takaomi C Saido; Kyoung-Jae Won; Jongpil Kim
Nature communications 14 (1) 802 - 802 2023/02 [Refereed]

Multifactorial glial responses and their contributions to AD continuum
Masanori Hijioka; Tatsuya Manabe; Takashi Saito
Clinical and Experimental Neuroimmunology Wiley 14 (2) 82 - 91 1759-1961 2023/02 [Refereed]
Multifactorial glial responses and their contributions to AD continuumMasanori Hijioka; Tatsuya Manabe; Takashi SaitoClinical and Experimental Neuroimmunology Wiley 14 (2) 82 - 91 1759-1961 2023/02 [R...See More
Multifactorial glial responses and their contributions to AD continuum
Masanori Hijioka; Tatsuya Manabe; Takashi Saito
Clinical and Experimental Neuroimmunology Wiley 14 (2) 82 - 91 1759-1961 2023/02 [Refereed]

Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.
Shoko Hashimoto; Yukio Matsuba; Mika Takahashi; Naoko Kamano; Naoto Watamura; Hiroki Sasaguri; Yuhei Takado; Yoshihiro Yoshihara; Takashi Saito; Takaomi C Saido
Scientific reports 13 (1) 1109 - 1109 2023/01 [Refereed]
Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.Shoko Hashimoto; Yukio Matsuba; Mika Takahashi; Naoko Kamano; Naoto Watamura; Hiroki Sasaguri; Yuhei Takado; Yoshihi...See More
Neuronal glutathione loss leads to neurodegeneration involving gasdermin activation.
Shoko Hashimoto; Yukio Matsuba; Mika Takahashi; Naoko Kamano; Naoto Watamura; Hiroki Sasaguri; Yuhei Takado; Yoshihiro Yoshihara; Takashi Saito; Takaomi C Saido
Scientific reports 13 (1) 1109 - 1109 2023/01 [Refereed]

Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
Yang Yang; Wenjuan Zhang; Alexey G Murzin; Manuel Schweighauser; Melissa Huang; Sofia Lövestam; Sew Y Peak-Chew; Takashi Saito; Takaomi C Saido; Jennifer Macdonald; Isabelle Lavenir; Bernardino Ghetti; Caroline Graff; Amit Kumar; Agneta Nordberg; Michel Goedert; Sjors H W Scheres
Acta neuropathologica 2023/01 [Refereed]
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.Yang Yang; Wenjuan Zhang; Alexey G Murzin; Manuel Schweighauser; Melissa Huang; Sofia Lövestam; Se...See More
Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.
Yang Yang; Wenjuan Zhang; Alexey G Murzin; Manuel Schweighauser; Melissa Huang; Sofia Lövestam; Sew Y Peak-Chew; Takashi Saito; Takaomi C Saido; Jennifer Macdonald; Isabelle Lavenir; Bernardino Ghetti; Caroline Graff; Amit Kumar; Agneta Nordberg; Michel Goedert; Sjors H W Scheres
Acta neuropathologica 2023/01 [Refereed]

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse.
Matthew J Benskey; Spencer Panoushek; Takashi Saito; Takaomi C Saido; Tessa Grabinski; Nicholas M Kanaan
Frontiers in aging neuroscience 15 1265151 - 1265151 2023 [Refereed]
Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse.Matthew J Benskey; Spencer Panoushek; Takashi Saito; Takaomi C Saido; Tessa Grabinski; Nichola...See More
Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse.
Matthew J Benskey; Spencer Panoushek; Takashi Saito; Takaomi C Saido; Tessa Grabinski; Nicholas M Kanaan
Frontiers in aging neuroscience 15 1265151 - 1265151 2023 [Refereed]

Regional contributions of D-serine to Alzheimer's disease pathology in male AppNL-G-F/NL-G-F mice.
Xiance Ni; Ran Inoue; Yi Wu; Tomoyuki Yoshida; Keisuke Yaku; Takashi Nakagawa; Takashi Saito; Takaomi C Saido; Keizo Takao; Hisashi Mori
Frontiers in aging neuroscience 15 1211067 - 1211067 2023 [Refereed]
Regional contributions of D-serine to Alzheimer's disease pathology in male AppNL-G-F/NL-G-F mice.Xiance Ni; Ran Inoue; Yi Wu; Tomoyuki Yoshida; Keisuke Yaku; Takashi Nakagawa; Takashi Saito; Takaomi ...See More
Regional contributions of D-serine to Alzheimer's disease pathology in male AppNL-G-F/NL-G-F mice.
Xiance Ni; Ran Inoue; Yi Wu; Tomoyuki Yoshida; Keisuke Yaku; Takashi Nakagawa; Takashi Saito; Takaomi C Saido; Keizo Takao; Hisashi Mori
Frontiers in aging neuroscience 15 1211067 - 1211067 2023 [Refereed]

Impairment in novelty-promoted memory via behavioral tagging and capture before apparent memory loss in a knock-in model of Alzheimer's disease.
Tabitha Broadbelt; Menekse Mutlu-Smith; Daniel Carnicero-Senabre; Takaomi C Saido; Takashi Saito; Szu-Han Wang
Scientific reports 12 (1) 22298 - 22298 2022/12 [Refereed]
Impairment in novelty-promoted memory via behavioral tagging and capture before apparent memory loss in a knock-in model of Alzheimer's disease.Tabitha Broadbelt; Menekse Mutlu-Smith; Daniel Carnicero...See More
Impairment in novelty-promoted memory via behavioral tagging and capture before apparent memory loss in a knock-in model of Alzheimer's disease.
Tabitha Broadbelt; Menekse Mutlu-Smith; Daniel Carnicero-Senabre; Takaomi C Saido; Takashi Saito; Szu-Han Wang
Scientific reports 12 (1) 22298 - 22298 2022/12 [Refereed]

G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.
Yunhong Huang; Thais Rafael Guimarães; Nicholas Todd; Carolyn Ferguson; Kathryn M Weiss; Fiona R Stauffer; Breanne McDermott; Bryan T Hurtle; Takashi Saito; Takaomi C Saido; Matthew L MacDonald; Gregg E Homanics; Amantha Thathiah
Proceedings of the National Academy of Sciences of the United States of America 119 (40) e2204828119 2022/10 [Refereed]
G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.Yunhong Huang; Thais Rafael Guimarães; Nicholas Todd; Carolyn Ferguson; Kathryn M Weiss; ...See More
G protein-biased GPR3 signaling ameliorates amyloid pathology in a preclinical Alzheimer's disease mouse model.
Yunhong Huang; Thais Rafael Guimarães; Nicholas Todd; Carolyn Ferguson; Kathryn M Weiss; Fiona R Stauffer; Breanne McDermott; Bryan T Hurtle; Takashi Saito; Takaomi C Saido; Matthew L MacDonald; Gregg E Homanics; Amantha Thathiah
Proceedings of the National Academy of Sciences of the United States of America 119 (40) e2204828119 2022/10 [Refereed]

CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease.
Hanseul Park; Jaein Shin; Yunkyung Kim; Takashi Saito; Takaomi C Saido; Jongpil Kim
Translational neurodegeneration 11 (1) 41 - 41 2022/09 [Refereed]
CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease.Hanseul Park; Jaein Shin; Yunkyung Kim; Takashi Saito; Takaomi C Saido; Jon...See More
CRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer's disease.
Hanseul Park; Jaein Shin; Yunkyung Kim; Takashi Saito; Takaomi C Saido; Jongpil Kim
Translational neurodegeneration 11 (1) 41 - 41 2022/09 [Refereed]

Multifunctional Therapeutic Cyclodextrin-Appended Dendrimer Complex for Treatment of Systemic and Localized Amyloidosis.
Masamichi Inoue; Taishi Higashi; Yuya Hayashi; Risako Onodera; Kazuya Fujisawa; Toru Taharabaru; Ryoma Yokoyama; Kenta Ouchi; Yohei Misumi; Mitsuharu Ueda; Yasuteru Inoue; Mineyuki Mizuguchi; Takashi Saito; Takaomi C Saido; Yukio Ando; Hidetoshi Arima; Keiichi Motoyama; Hirofumi Jono
ACS applied materials & interfaces 14 (36) 40599 - 40611 2022/09 [Refereed]
Multifunctional Therapeutic Cyclodextrin-Appended Dendrimer Complex for Treatment of Systemic and Localized Amyloidosis.Masamichi Inoue; Taishi Higashi; Yuya Hayashi; Risako Onodera; Kazuya Fujisawa; ...See More
Multifunctional Therapeutic Cyclodextrin-Appended Dendrimer Complex for Treatment of Systemic and Localized Amyloidosis.
Masamichi Inoue; Taishi Higashi; Yuya Hayashi; Risako Onodera; Kazuya Fujisawa; Toru Taharabaru; Ryoma Yokoyama; Kenta Ouchi; Yohei Misumi; Mitsuharu Ueda; Yasuteru Inoue; Mineyuki Mizuguchi; Takashi Saito; Takaomi C Saido; Yukio Ando; Hidetoshi Arima; Keiichi Motoyama; Hirofumi Jono
ACS applied materials & interfaces 14 (36) 40599 - 40611 2022/09 [Refereed]

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21.
Paige Mumford; Justin Tosh; Silvia Anderle; Eleni Gkanatsiou Wikberg; Gloria Lau; Sue Noy; Karen Cleverley; Takashi Saito; Takaomi C Saido; Eugene Yu; Gunnar Brinkmalm; Erik Portelius; Kaj Blennow; Henrik Zetterberg; Victor Tybulewicz; Elizabeth M C Fisher; Frances K Wiseman
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022/07 [Refereed]
Genetic mapping of APP and amyloid-β biology modulation by trisomy 21.Paige Mumford; Justin Tosh; Silvia Anderle; Eleni Gkanatsiou Wikberg; Gloria Lau; Sue Noy; Karen Cleverley; Takashi Saito; Takaomi...See More
Genetic mapping of APP and amyloid-β biology modulation by trisomy 21.
Paige Mumford; Justin Tosh; Silvia Anderle; Eleni Gkanatsiou Wikberg; Gloria Lau; Sue Noy; Karen Cleverley; Takashi Saito; Takaomi C Saido; Eugene Yu; Gunnar Brinkmalm; Erik Portelius; Kaj Blennow; Henrik Zetterberg; Victor Tybulewicz; Elizabeth M C Fisher; Frances K Wiseman
The Journal of neuroscience : the official journal of the Society for Neuroscience 2022/07 [Refereed]

Hippocampal neural circuit connectivity alterations in an Alzheimer's disease mouse model revealed by monosynaptic rabies virus tracing.
Qiao Ye; Gocylen Gast; Xilin Su; Takashi Saito; Takaomi C Saido; Todd C Holmes; Xiangmin Xu
Neurobiology of disease 172 105820 - 105820 2022/07 [Refereed]
Hippocampal neural circuit connectivity alterations in an Alzheimer's disease mouse model revealed by monosynaptic rabies virus tracing.Qiao Ye; Gocylen Gast; Xilin Su; Takashi Saito; Takaomi C Saido;...See More
Hippocampal neural circuit connectivity alterations in an Alzheimer's disease mouse model revealed by monosynaptic rabies virus tracing.
Qiao Ye; Gocylen Gast; Xilin Su; Takashi Saito; Takaomi C Saido; Todd C Holmes; Xiangmin Xu
Neurobiology of disease 172 105820 - 105820 2022/07 [Refereed]

Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain.
Ayano Ishii; Yukio Matsuba; Naomi Mihira; Naoko Kamano; Takashi Saito; Shin-Ichi Muramatsu; Makoto Yokosuka; Takaomi C Saido; Shoko Hashimoto
Journal of biochemistry 2022/07 [Refereed]
Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain.Ayano Ishii; Yukio Matsuba; Naomi Mihira; Naoko Kamano; Takashi Saito; Shin-Ichi Muramatsu; Makoto Yokosuka; Takaomi C Saido; Sh...See More
Tau-binding protein PRMT8 facilitates vacuole degeneration in the brain.
Ayano Ishii; Yukio Matsuba; Naomi Mihira; Naoko Kamano; Takashi Saito; Shin-Ichi Muramatsu; Makoto Yokosuka; Takaomi C Saido; Shoko Hashimoto
Journal of biochemistry 2022/07 [Refereed]

Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.
Sarah M Carpanini; Megan Torvell; Ryan J Bevan; Robert A J Byrne; Nikoleta Daskoulidou; Takashi Saito; Takaomi C Saido; Philip R Taylor; Timothy R Hughes; Wioleta M Zelek; B Paul Morgan
Acta neuropathologica communications 10 (1) 99 - 99 2022/07 [Refereed]
Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.Sarah M Carpanini; Megan Torvell; Ryan J Bevan; Robert A J Byrne; Nikoleta Daskoulidou; Takashi Saito; Takaomi...See More
Terminal complement pathway activation drives synaptic loss in Alzheimer's disease models.
Sarah M Carpanini; Megan Torvell; Ryan J Bevan; Robert A J Byrne; Nikoleta Daskoulidou; Takashi Saito; Takaomi C Saido; Philip R Taylor; Timothy R Hughes; Wioleta M Zelek; B Paul Morgan
Acta neuropathologica communications 10 (1) 99 - 99 2022/07 [Refereed]

Expression of Transferrin Protein and Messenger RNA in Neural Cells from Mouse and Human Brain Tissue.
Eriko Abe; Takashi J Fuwa; Kyoka Hoshi; Takashi Saito; Takenobu Murakami; Masakazu Miyajima; Norihiro Ogawa; Hiroyasu Akatsu; Yoshio Hashizume; Yasuhiro Hashimoto; Takashi Honda
Metabolites 12 (7) 2022/06 [Refereed]
Expression of Transferrin Protein and Messenger RNA in Neural Cells from Mouse and Human Brain Tissue.Eriko Abe; Takashi J Fuwa; Kyoka Hoshi; Takashi Saito; Takenobu Murakami; Masakazu Miyajima; Norih...See More
Expression of Transferrin Protein and Messenger RNA in Neural Cells from Mouse and Human Brain Tissue.
Eriko Abe; Takashi J Fuwa; Kyoka Hoshi; Takashi Saito; Takenobu Murakami; Masakazu Miyajima; Norihiro Ogawa; Hiroyasu Akatsu; Yoshio Hashizume; Yasuhiro Hashimoto; Takashi Honda
Metabolites 12 (7) 2022/06 [Refereed]

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.
Naoto Watamura; Kaori Sato; Gen Shiihashi; Ayami Iwasaki; Naoko Kamano; Mika Takahashi; Misaki Sekiguchi; Naomi Mihira; Ryo Fujioka; Kenichi Nagata; Shoko Hashimoto; Takashi Saito; Toshio Ohshima; Takaomi C Saido; Hiroki Sasaguri
Science advances 8 (23) eabm6155 2022/06 [Refereed]
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.Naoto Watamura; Kaori Sato; Gen Shiihashi; Ayami Iwasaki; Naoko Kamano; Mika Takahashi; Mis...See More
An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalities.
Naoto Watamura; Kaori Sato; Gen Shiihashi; Ayami Iwasaki; Naoko Kamano; Mika Takahashi; Misaki Sekiguchi; Naomi Mihira; Ryo Fujioka; Kenichi Nagata; Shoko Hashimoto; Takashi Saito; Toshio Ohshima; Takaomi C Saido; Hiroki Sasaguri
Science advances 8 (23) eabm6155 2022/06 [Refereed]

Propolis Promotes Memantine-Dependent Rescue of Cognitive Deficits in APP-KI Mice.
Shigeki Moriguchi; Ryo Inagaki; Takashi Saito; Takaomi C Saido; Kohji Fukunaga
Molecular neurobiology 2022/05 [Refereed]
Propolis Promotes Memantine-Dependent Rescue of Cognitive Deficits in APP-KI Mice.Shigeki Moriguchi; Ryo Inagaki; Takashi Saito; Takaomi C Saido; Kohji FukunagaMolecular neurobiology 2022/05 [Refereed...See More
Propolis Promotes Memantine-Dependent Rescue of Cognitive Deficits in APP-KI Mice.
Shigeki Moriguchi; Ryo Inagaki; Takashi Saito; Takaomi C Saido; Kohji Fukunaga
Molecular neurobiology 2022/05 [Refereed]

Effects of high-fat diet on nutrient metabolism and cognitive functions in young APPKINL-G-F/NL-G-F mice.
Wei Wang; Daisuke Tanokashira; Yudai Shibayama; Ryuhei Tsuji; Megumi Maruyama; Chiemi Kuroiwa; Takashi Saito; Takaomi C Saido; Akiko Taguchi
Neuropsychopharmacology reports 2022/05 [Refereed]
Effects of high-fat diet on nutrient metabolism and cognitive functions in young APPKINL-G-F/NL-G-F mice.Wei Wang; Daisuke Tanokashira; Yudai Shibayama; Ryuhei Tsuji; Megumi Maruyama; Chiemi Kuroiwa; ...See More
Effects of high-fat diet on nutrient metabolism and cognitive functions in young APPKINL-G-F/NL-G-F mice.
Wei Wang; Daisuke Tanokashira; Yudai Shibayama; Ryuhei Tsuji; Megumi Maruyama; Chiemi Kuroiwa; Takashi Saito; Takaomi C Saido; Akiko Taguchi
Neuropsychopharmacology reports 2022/05 [Refereed]

Expression of Olfactory-Related Genes in the Olfactory Epithelium of an Alzheimer's Disease Mouse Model.
Masataka Narukawa; Yuko Mori; Riko Nishida; Suzuka Takahashi; Takashi Saito; Takaomi C Saido; Takumi Misaka
Journal of Alzheimer's disease : JAD 88 (1) 29 - 35 2022/05 [Refereed]
Expression of Olfactory-Related Genes in the Olfactory Epithelium of an Alzheimer's Disease Mouse Model.Masataka Narukawa; Yuko Mori; Riko Nishida; Suzuka Takahashi; Takashi Saito; Takaomi C Saido; Ta...See More
Expression of Olfactory-Related Genes in the Olfactory Epithelium of an Alzheimer's Disease Mouse Model.
Masataka Narukawa; Yuko Mori; Riko Nishida; Suzuka Takahashi; Takashi Saito; Takaomi C Saido; Takumi Misaka
Journal of Alzheimer's disease : JAD 88 (1) 29 - 35 2022/05 [Refereed]

High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer's Disease.
Kyoka Hoshi; Mayumi Kanno; Mitsunari Abe; Takenobu Murakami; Yoshikazu Ugawa; Aya Goto; Takashi Honda; Takashi Saito; Takaomi C Saido; Yoshiki Yamaguchi; Masakazu Miyajima; Katsutoshi Furukawa; Hiroyuki Arai; Yasuhiro Hashimoto
Metabolites 12 (4) 2022/04 [Refereed]
High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer's Disease.Kyoka Hoshi; Mayumi Kanno; Mitsunari Abe; ...See More
High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer's Disease.
Kyoka Hoshi; Mayumi Kanno; Mitsunari Abe; Takenobu Murakami; Yoshikazu Ugawa; Aya Goto; Takashi Honda; Takashi Saito; Takaomi C Saido; Yoshiki Yamaguchi; Masakazu Miyajima; Katsutoshi Furukawa; Hiroyuki Arai; Yasuhiro Hashimoto
Metabolites 12 (4) 2022/04 [Refereed]

Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer's disease.
Yuki Kobayashi; Shogo Kohbuchi; Noriko Koganezawa; Yuko Sekino; Tomoaki Shirao; Takaomi C Saido; Takashi Saito; Yumiko Saito
Biochemical and biophysical research communications 610 85 - 91 2022/04 [Refereed]
Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer's disease.Yuki Kobayashi; Shogo Kohbuchi; Noriko Koganezawa; Yuko Sekino; Tomoaki Shirao; Takaomi C Saido; Takashi Saito; Yum...See More
Impairment of ciliary dynamics in an APP knock-in mouse model of Alzheimer's disease.
Yuki Kobayashi; Shogo Kohbuchi; Noriko Koganezawa; Yuko Sekino; Tomoaki Shirao; Takaomi C Saido; Takashi Saito; Yumiko Saito
Biochemical and biophysical research communications 610 85 - 91 2022/04 [Refereed]

Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged AppNL-G-F/NL-G-F mice.
Ryo Niikura; Tomoyuki Miyazaki; Kenkichi Takase; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Takahisa Goto
Molecular brain 15 (1) 32 - 32 2022/04 [Refereed]
Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged AppNL-G-F/NL-G-F mice.Ryo Niikura; Tomoyuki Miyazaki; Kenkichi Takase; Hiroki Sasaguri; Takashi Saito;...See More
Assessments of prolonged effects of desflurane and sevoflurane on motor learning deficits in aged AppNL-G-F/NL-G-F mice.
Ryo Niikura; Tomoyuki Miyazaki; Kenkichi Takase; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Takahisa Goto
Molecular brain 15 (1) 32 - 32 2022/04 [Refereed]

Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice.
Yuriko Tachida; Saori Miura; Yui Muto; Hiroyuki Takuwa; Naruhiko Sahara; Akihiro Shindo; Yukio Matsuba; Takashi Saito; Naoyuki Taniguchi; Yasushi Kawaguchi; Hidekazu Tomimoto; Takaomi Saido; Shinobu Kitazume
The Journal of biological chemistry 298 (6) 101880 - 101880 2022/03 [Refereed]
Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice.Yuriko Tachida; Saori Miura; Yui Muto; Hiroyuki Takuw...See More
Endothelial expression of human amyloid precursor protein leads to amyloid β in the blood and induces cerebral amyloid angiopathy in knock-in mice.
Yuriko Tachida; Saori Miura; Yui Muto; Hiroyuki Takuwa; Naruhiko Sahara; Akihiro Shindo; Yukio Matsuba; Takashi Saito; Naoyuki Taniguchi; Yasushi Kawaguchi; Hidekazu Tomimoto; Takaomi Saido; Shinobu Kitazume
The Journal of biological chemistry 298 (6) 101880 - 101880 2022/03 [Refereed]

AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model.
Marika Marino; Lujia Zhou; Melvin Y Rincon; Zsuzsanna Callaerts-Vegh; Jens Verhaert; Jérôme Wahis; Eline Creemers; Lidia Yshii; Keimpe Wierda; Takashi Saito; Catherine Marneffe; Iryna Voytyuk; Yessica Wouters; Maarten Dewilde; Sandra I Duqué; Cécile Vincke; Yona Levites; Todd E Golde; Takaomi C Saido; Serge Muyldermans; Adrian Liston; Bart De Strooper; Matthew G Holt
EMBO molecular medicine e09824 2022/03 [Refereed]
AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model.Marika Marino; Lujia Zhou; Melvin Y Rincon; Zsuzsanna Callaerts-Vegh; Jens Verhaert; Jérôme Wahis; Eline...See More
AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model.
Marika Marino; Lujia Zhou; Melvin Y Rincon; Zsuzsanna Callaerts-Vegh; Jens Verhaert; Jérôme Wahis; Eline Creemers; Lidia Yshii; Keimpe Wierda; Takashi Saito; Catherine Marneffe; Iryna Voytyuk; Yessica Wouters; Maarten Dewilde; Sandra I Duqué; Cécile Vincke; Yona Levites; Todd E Golde; Takaomi C Saido; Serge Muyldermans; Adrian Liston; Bart De Strooper; Matthew G Holt
EMBO molecular medicine e09824 2022/03 [Refereed]

Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease.
Nanaka Kaneshiro; Masato Komai; Ryosuke Imaoka; Atsuya Ikeda; Yuji Kamikubo; Takashi Saito; Takaomi C Saido; Taisuke Tomita; Tadafumi Hashimoto; Takeshi Iwatsubo; Takashi Sakurai; Takashi Uehara; Nobumasa Takasugi
iScience 25 (3) 103869 - 103869 2022/03 [Refereed]
Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease.Nanaka Kaneshiro; Masato Komai; Ryosuke Imaoka; Atsuya Ikeda; Yuji Kamikubo; Takashi Saito; Takaomi C ...See More
Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer's disease.
Nanaka Kaneshiro; Masato Komai; Ryosuke Imaoka; Atsuya Ikeda; Yuji Kamikubo; Takashi Saito; Takaomi C Saido; Taisuke Tomita; Tadafumi Hashimoto; Takeshi Iwatsubo; Takashi Sakurai; Takashi Uehara; Nobumasa Takasugi
iScience 25 (3) 103869 - 103869 2022/03 [Refereed]

Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.
Ernest Palomer; Núria Martín-Flores; Sarah Jolly; Patricia Pascual-Vargas; Stefano Benvegnù; Marina Podpolny; Samuel Teo; Kadi Vaher; Takashi Saito; Takaomi C Saido; Paul Whiting; Patricia C Salinas
Molecular psychiatry 2022/03 [Refereed]
Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.Ernest Palomer; Núria Martín-Flores; Sarah Jolly; Patricia Pascual-...See More
Epigenetic repression of Wnt receptors in AD: a role for Sirtuin2-induced H4K16ac deacetylation of Frizzled1 and Frizzled7 promoters.
Ernest Palomer; Núria Martín-Flores; Sarah Jolly; Patricia Pascual-Vargas; Stefano Benvegnù; Marina Podpolny; Samuel Teo; Kadi Vaher; Takashi Saito; Takaomi C Saido; Paul Whiting; Patricia C Salinas
Molecular psychiatry 2022/03 [Refereed]

Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer's disease.
Anam Islam; Takashi Saito; Takaomi Saido; Afia B Ali
Seminars in cell & developmental biology 2022/03 [Refereed]
Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer's disease.Anam Islam; Takashi Saito; Takaomi Saido; Afia B AliSeminars in cell & developmenta...See More
Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer's disease.
Anam Islam; Takashi Saito; Takaomi Saido; Afia B Ali
Seminars in cell & developmental biology 2022/03 [Refereed]

Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.
Celia A McKee; Jiyeon Lee; Yuqi Cai; Takashi Saito; Takaomi Saido; Erik S Musiek
Scientific reports 12 (1) 1796 - 1796 2022/02 [Refereed]
Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.Celia A McKee; Jiyeon Lee; Yuqi Cai; Takashi Saito; Takao...See More
Astrocytes deficient in circadian clock gene Bmal1 show enhanced activation responses to amyloid-beta pathology without changing plaque burden.
Celia A McKee; Jiyeon Lee; Yuqi Cai; Takashi Saito; Takaomi Saido; Erik S Musiek
Scientific reports 12 (1) 1796 - 1796 2022/02 [Refereed]

Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models.
Daniel Zarhin; Refaela Atsmon; Antonella Ruggiero; Halit Baeloha; Shiri Shoob; Oded Scharf; Leore R Heim; Nadav Buchbinder; Ortal Shinikamin; Ilana Shapira; Boaz Styr; Gabriella Braun; Michal Harel; Anton Sheinin; Nitzan Geva; Yaniv Sela; Takashi Saito; Takaomi Saido; Tamar Geiger; Yuval Nir; Yaniv Ziv; Inna Slutsky
Cell reports 38 (3) 110268 - 110268 2022/01 [Refereed]
Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models.Daniel Zarhin; Refaela Atsmon; Antonella Ruggiero; Halit Baeloha; Shiri Shoob; Oded Scharf; Le...See More
Disrupted neural correlates of anesthesia and sleep reveal early circuit dysfunctions in Alzheimer models.
Daniel Zarhin; Refaela Atsmon; Antonella Ruggiero; Halit Baeloha; Shiri Shoob; Oded Scharf; Leore R Heim; Nadav Buchbinder; Ortal Shinikamin; Ilana Shapira; Boaz Styr; Gabriella Braun; Michal Harel; Anton Sheinin; Nitzan Geva; Yaniv Sela; Takashi Saito; Takaomi Saido; Tamar Geiger; Yuval Nir; Yaniv Ziv; Inna Slutsky
Cell reports 38 (3) 110268 - 110268 2022/01 [Refereed]

Therapeutic effects of anti-amyloid β antibody after intravenous injection and efficient nose-to-brain delivery in Alzheimer's disease mouse model.
Noriyasu Kamei; Ayaka Hashimoto; Erina Tanaka; Kaho Murata; Maika Yamaguchi; Natsuki Yokoyama; Masahiro Kato; Keisuke Oki; Takashi Saito; Takaomi C Saido; Mariko Takeda-Morishita
Drug delivery and translational research 2022/01 [Refereed]
Therapeutic effects of anti-amyloid β antibody after intravenous injection and efficient nose-to-brain delivery in Alzheimer's disease mouse model.Noriyasu Kamei; Ayaka Hashimoto; Erina Tanaka; Kaho M...See More
Therapeutic effects of anti-amyloid β antibody after intravenous injection and efficient nose-to-brain delivery in Alzheimer's disease mouse model.
Noriyasu Kamei; Ayaka Hashimoto; Erina Tanaka; Kaho Murata; Maika Yamaguchi; Natsuki Yokoyama; Masahiro Kato; Keisuke Oki; Takashi Saito; Takaomi C Saido; Mariko Takeda-Morishita
Drug delivery and translational research 2022/01 [Refereed]

Early memory deficits and extensive brain network disorganization in the AppNL-F/MAPT double knock-in mouse model of familial Alzheimer's disease.
Christopher Borcuk; Céline Héraud; Karine Herbeaux; Margot Diringer; Élodie Panzer; Jil Scuto; Shoko Hashimoto; Takaomi C Saido; Takashi Saito; Romain Goutagny; Demian Battaglia; Chantal Mathis
Aging brain 2 100042 - 100042 2022 [Refereed]
Early memory deficits and extensive brain network disorganization in the AppNL-F/MAPT double knock-in mouse model of familial Alzheimer's disease.Christopher Borcuk; Céline Héraud; Karine Herbeaux; Ma...See More
Early memory deficits and extensive brain network disorganization in the AppNL-F/MAPT double knock-in mouse model of familial Alzheimer's disease.
Christopher Borcuk; Céline Héraud; Karine Herbeaux; Margot Diringer; Élodie Panzer; Jil Scuto; Shoko Hashimoto; Takaomi C Saido; Takashi Saito; Romain Goutagny; Demian Battaglia; Chantal Mathis
Aging brain 2 100042 - 100042 2022 [Refereed]

Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease.
Zachery D Morrissey; Jin Gao; Liang Zhan; Weiguo Li; Igor Fortel; Takaomi Saido; Takashi Saito; Arnold Bakker; Scott Mackin; Olusola Ajilore; Orly Lazarov; Alex D Leow
Frontiers in aging neuroscience 14 1085989 - 1085989 2022 [Refereed]
Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease.Zachery D Morrissey; Jin Gao; Liang Zhan; Weiguo Li; Igor Fortel; Takaomi Saido; Takashi Saito; Arn...See More
Hippocampal functional connectivity across age in an App knock-in mouse model of Alzheimer's disease.
Zachery D Morrissey; Jin Gao; Liang Zhan; Weiguo Li; Igor Fortel; Takaomi Saido; Takashi Saito; Arnold Bakker; Scott Mackin; Olusola Ajilore; Orly Lazarov; Alex D Leow
Frontiers in aging neuroscience 14 1085989 - 1085989 2022 [Refereed]

Age-Dependent Behavioral and Metabolic Assessment of App NL-G-F/NL-G-F Knock-in (KI) Mice.
Shanshan Wang; Taiga Ichinomiya; Paul Savchenko; Swetha Devulapalli; Dongsheng Wang; Gianna Beltz; Takashi Saito; Takaomi C Saido; Steve L Wagner; Hemal H Patel; Brian P Head
Frontiers in molecular neuroscience 15 909989 - 909989 2022 [Refereed]
Age-Dependent Behavioral and Metabolic Assessment of App NL-G-F/NL-G-F Knock-in (KI) Mice.Shanshan Wang; Taiga Ichinomiya; Paul Savchenko; Swetha Devulapalli; Dongsheng Wang; Gianna Beltz; Takashi Sai...See More
Age-Dependent Behavioral and Metabolic Assessment of App NL-G-F/NL-G-F Knock-in (KI) Mice.
Shanshan Wang; Taiga Ichinomiya; Paul Savchenko; Swetha Devulapalli; Dongsheng Wang; Gianna Beltz; Takashi Saito; Takaomi C Saido; Steve L Wagner; Hemal H Patel; Brian P Head
Frontiers in molecular neuroscience 15 909989 - 909989 2022 [Refereed]

β-secretase inhibition prevents structural spine plasticity deficits in App NL-G-F mice.
Tanja Blume; Severin Filser; Carmelo Sgobio; Finn Peters; Ulf Neumann; Derya Shimshek; Takashi Saito; Takaomi C Saido; Matthias Brendel; Jochen Herms
Frontiers in aging neuroscience 14 909586 - 909586 2022 [Refereed]
β-secretase inhibition prevents structural spine plasticity deficits in App NL-G-F mice.Tanja Blume; Severin Filser; Carmelo Sgobio; Finn Peters; Ulf Neumann; Derya Shimshek; Takashi Saito; Takaomi C ...See More
β-secretase inhibition prevents structural spine plasticity deficits in App NL-G-F mice.
Tanja Blume; Severin Filser; Carmelo Sgobio; Finn Peters; Ulf Neumann; Derya Shimshek; Takashi Saito; Takaomi C Saido; Matthias Brendel; Jochen Herms
Frontiers in aging neuroscience 14 909586 - 909586 2022 [Refereed]

Recent Advances in the Modeling of Alzheimer's Disease.
Hiroki Sasaguri; Shoko Hashimoto; Naoto Watamura; Kaori Sato; Risa Takamura; Kenichi Nagata; Satoshi Tsubuki; Toshio Ohshima; Atsushi Yoshiki; Kenya Sato; Wakako Kumita; Erika Sasaki; Shinobu Kitazume; Per Nilsson; Bengt Winblad; Takashi Saito; Nobuhisa Iwata; Takaomi C Saido
Frontiers in neuroscience 16 807473 - 807473 2022 [Refereed]
Recent Advances in the Modeling of Alzheimer's Disease.Hiroki Sasaguri; Shoko Hashimoto; Naoto Watamura; Kaori Sato; Risa Takamura; Kenichi Nagata; Satoshi Tsubuki; Toshio Ohshima; Atsushi Yoshiki; Ke...See More
Recent Advances in the Modeling of Alzheimer's Disease.
Hiroki Sasaguri; Shoko Hashimoto; Naoto Watamura; Kaori Sato; Risa Takamura; Kenichi Nagata; Satoshi Tsubuki; Toshio Ohshima; Atsushi Yoshiki; Kenya Sato; Wakako Kumita; Erika Sasaki; Shinobu Kitazume; Per Nilsson; Bengt Winblad; Takashi Saito; Nobuhisa Iwata; Takaomi C Saido
Frontiers in neuroscience 16 807473 - 807473 2022 [Refereed]

Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice.
Xiaoxiao Hao; Zhaofei Li; Wei Li; Jannet Katz; Suzanne M Michalek; Scott R Barnum; Lucas Pozzo-Miller; Takashi Saito; Takaomi C Saido; Qin Wang; Erik D Roberson; Ping Zhang
Frontiers in immunology 13 816640 - 816640 2022 [Refereed]
Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice.Xiaoxiao Hao; Zhaofei Li; Wei Li; Jannet Katz; Suzanne M Michalek; Scott R Barnum; Lucas Poz...See More
Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer's Mice.
Xiaoxiao Hao; Zhaofei Li; Wei Li; Jannet Katz; Suzanne M Michalek; Scott R Barnum; Lucas Pozzo-Miller; Takashi Saito; Takaomi C Saido; Qin Wang; Erik D Roberson; Ping Zhang
Frontiers in immunology 13 816640 - 816640 2022 [Refereed]

Amelioration of Alzheimer's Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model.
Mayumi Minamisawa; Yuma Sato; Eitarou Ishiguro; Tetsuyuki Taniai; Taiichi Sakamoto; Gota Kawai; Takashi Saito; Takaomi C Saido
Life (Basel, Switzerland) 12 (1) 2021/12 [Refereed]
Amelioration of Alzheimer's Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model.Mayumi Minamisawa; Yuma Sato; Eitarou Ishiguro; Tetsuyuki Taniai; Taiichi Sakamoto; Gota Kawa...See More
Amelioration of Alzheimer's Disease by Gut-Pancreas-Liver-Brain Interaction in an App Knock-In Mouse Model.
Mayumi Minamisawa; Yuma Sato; Eitarou Ishiguro; Tetsuyuki Taniai; Taiichi Sakamoto; Gota Kawai; Takashi Saito; Takaomi C Saido
Life (Basel, Switzerland) 12 (1) 2021/12 [Refereed]

Assessing Sex-Specific Circadian, Metabolic, and Cognitive Phenotypes in the AβPP/PS1 and APPNL - F/NL - F Models of Alzheimer's Disease.
Jesse Britz; Emmanuel Ojo; Asmita Dhukhwa; Takashi Saito; Takaomi C Saido; Erin R Hascup; Kevin N Hascup; Shelley A Tischkau
Journal of Alzheimer's disease : JAD 2021/12 [Refereed]
Assessing Sex-Specific Circadian, Metabolic, and Cognitive Phenotypes in the AβPP/PS1 and APPNL - F/NL - F Models of Alzheimer's Disease.Jesse Britz; Emmanuel Ojo; Asmita Dhukhwa; Takashi Saito; Takao...See More
Assessing Sex-Specific Circadian, Metabolic, and Cognitive Phenotypes in the AβPP/PS1 and APPNL - F/NL - F Models of Alzheimer's Disease.
Jesse Britz; Emmanuel Ojo; Asmita Dhukhwa; Takashi Saito; Takaomi C Saido; Erin R Hascup; Kevin N Hascup; Shelley A Tischkau
Journal of Alzheimer's disease : JAD 2021/12 [Refereed]

Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior.
Yuri Mizuno; Nona Abolhassani; Guianfranco Mazzei; Takashi Saito; Takaomi C Saido; Ryo Yamasaki; Jun-Ichi Kira; Yusaku Nakabeppu
Neuroscience research 177 118 - 134 2021/11 [Refereed]
Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and ...See More
Deficiency of MTH1 and/or OGG1 increases the accumulation of 8-oxoguanine in the brain of the AppNL-G-F/NL-G-F knock-in mouse model of Alzheimer's disease, accompanied by accelerated microgliosis and reduced anxiety-like behavior.
Yuri Mizuno; Nona Abolhassani; Guianfranco Mazzei; Takashi Saito; Takaomi C Saido; Ryo Yamasaki; Jun-Ichi Kira; Yusaku Nakabeppu
Neuroscience research 177 118 - 134 2021/11 [Refereed]

Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin.
Xiao Liu; Qian Zhou; Jia-He Zhang; Ke-Yong Wang; Takashi Saito; Takaomi C Saido; Xiaoying Wang; Xiumei Gao; Kagaku Azuma
Cells 10 (11) 2021/11 [Refereed]
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin.Xiao Liu; Qian Zhou; Jia-He Zhang; Ke-Yong Wang; Takashi Sai...See More
Microglia-Based Sex-Biased Neuropathology in Early-Stage Alzheimer's Disease Model Mice and the Potential Pharmacologic Efficacy of Dioscin.
Xiao Liu; Qian Zhou; Jia-He Zhang; Ke-Yong Wang; Takashi Saito; Takaomi C Saido; Xiaoying Wang; Xiumei Gao; Kagaku Azuma
Cells 10 (11) 2021/11 [Refereed]

Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway.
Naoto Watamura; Naomasa Kakiya; Per Nilsson; Satoshi Tsubuki; Naoko Kamano; Mika Takahashi; Shoko Hashimoto; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido
Molecular psychiatry 2021/11 [Refereed]
Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway.Naoto Watamura; Naomasa Kakiya; Per Nilsson; Satoshi Tsubuki; Naoko Kamano; Mika Takahashi...See More
Somatostatin-evoked Aβ catabolism in the brain: Mechanistic involvement of α-endosulfine-KATP channel pathway.
Naoto Watamura; Naomasa Kakiya; Per Nilsson; Satoshi Tsubuki; Naoko Kamano; Mika Takahashi; Shoko Hashimoto; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido
Molecular psychiatry 2021/11 [Refereed]

Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models.
Eduardo Pauls; Sergi Bayod; Lídia Mateo; Víctor Alcalde; Teresa Juan-Blanco; Marta Sánchez-Soto; Takaomi C Saido; Takashi Saito; Antoni Berrenguer-Llergo; Camille Stephan-Otto Attolini; Marina Gay; Eliandre de Oliveira; Miquel Duran-Frigola; Patrick Aloy
Genome medicine 13 (1) 168 - 168 2021/10 [Refereed]
Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models.Eduardo Pauls; Sergi Bayod; Lídia Mateo; ...See More
Identification and drug-induced reversion of molecular signatures of Alzheimer's disease onset and progression in AppNL-G-F, AppNL-F, and 3xTg-AD mouse models.
Eduardo Pauls; Sergi Bayod; Lídia Mateo; Víctor Alcalde; Teresa Juan-Blanco; Marta Sánchez-Soto; Takaomi C Saido; Takashi Saito; Antoni Berrenguer-Llergo; Camille Stephan-Otto Attolini; Marina Gay; Eliandre de Oliveira; Miquel Duran-Frigola; Patrick Aloy
Genome medicine 13 (1) 168 - 168 2021/10 [Refereed]

HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.
Hikari Tanaka; Kanoh Kondo; Kyota Fujita; Hidenori Homma; Kazuhiko Tagawa; Xiaocen Jin; Meihua Jin; Yuki Yoshioka; Sumire Takayama; Hitomi Masuda; Rie Tokuyama; Yukoh Nakazaki; Takashi Saito; Takaomi Saido; Shigeo Murayama; Teikichi Ikura; Nobutoshi Ito; Yu Yamamori; Kentaro Tomii; Marco E Bianchi; Hitoshi Okazawa
Communications biology 4 (1) 1175 - 1175 2021/10 [Refereed]
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.Hikari Tanaka; Kanoh Kondo; Kyota Fujita; Hidenori Homma; Kazuhiko Tagawa; Xiaocen Jin; Meihua Jin; Y...See More
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.
Hikari Tanaka; Kanoh Kondo; Kyota Fujita; Hidenori Homma; Kazuhiko Tagawa; Xiaocen Jin; Meihua Jin; Yuki Yoshioka; Sumire Takayama; Hitomi Masuda; Rie Tokuyama; Yukoh Nakazaki; Takashi Saito; Takaomi Saido; Shigeo Murayama; Teikichi Ikura; Nobutoshi Ito; Yu Yamamori; Kentaro Tomii; Marco E Bianchi; Hitoshi Okazawa
Communications biology 4 (1) 1175 - 1175 2021/10 [Refereed]

Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease.
Xiaoting Wu; Takashi Saito; Takaomi C Saido; Anna M Barron; Christiane Ruedl
eLife 10 2021/10 [Refereed]
Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease.Xiaoting Wu; Takashi Saito; Takaomi C Saido; Anna M Barron; Christiane RuedleLife 10...See More
Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease.
Xiaoting Wu; Takashi Saito; Takaomi C Saido; Anna M Barron; Christiane Ruedl
eLife 10 2021/10 [Refereed]

Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer's Disease.
Kyoka Hoshi; Hiromi Ito; Eriko Abe; Takashi J Fuwa; Mayumi Kanno; Yuta Murakami; Mitsunari Abe; Takenobu Murakami; Akioh Yoshihara; Yoshikazu Ugawa; Takashi Saito; Takaomi C Saido; Kana Matsumoto; Yoshiki Yamaguchi; Katsutoshi Furukawa; Hiroyuki Arai; Mitsuyasu Kanai; Masakazu Miyajima; Hajime Arai; Norihiro Ogawa; Hiroyasu Akatsu; Yoshio Hashizume; Hiroaki Tateno; Takashi Honda; Yasuhiro Hashimoto
Metabolites 11 (9) 2021/09 [Refereed]
Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer's Disease.Kyoka Hoshi; Hiromi Ito; Eriko Abe; Takashi J Fuwa; Mayumi Kanno; Yuta Murakami; Mitsunari Abe; Takenobu Murakami; ...See More
Transferrin Biosynthesized in the Brain Is a Novel Biomarker for Alzheimer's Disease.
Kyoka Hoshi; Hiromi Ito; Eriko Abe; Takashi J Fuwa; Mayumi Kanno; Yuta Murakami; Mitsunari Abe; Takenobu Murakami; Akioh Yoshihara; Yoshikazu Ugawa; Takashi Saito; Takaomi C Saido; Kana Matsumoto; Yoshiki Yamaguchi; Katsutoshi Furukawa; Hiroyuki Arai; Mitsuyasu Kanai; Masakazu Miyajima; Hajime Arai; Norihiro Ogawa; Hiroyasu Akatsu; Yoshio Hashizume; Hiroaki Tateno; Takashi Honda; Yasuhiro Hashimoto
Metabolites 11 (9) 2021/09 [Refereed]

Author Correction: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.
Erika Castillo; Julio Leon; Guianfranco Mazzei; Nona Abolhassani; Naoki Haruyama; Takashi Saito; Takaomi Saido; Masaaki Hokama; Toru Iwaki; Tomoyuki Ohara; Toshiharu Ninomiya; Yutaka Kiyohara; Kunihiko Sakumi; Frank M LaFerla; Yusaku Nakabeppu
Scientific reports 11 (1) 18377 - 18377 2021/09
Author Correction: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.Erika Castillo; Juli...See More
Author Correction: Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation.
Erika Castillo; Julio Leon; Guianfranco Mazzei; Nona Abolhassani; Naoki Haruyama; Takashi Saito; Takaomi Saido; Masaaki Hokama; Toru Iwaki; Tomoyuki Ohara; Toshiharu Ninomiya; Yutaka Kiyohara; Kunihiko Sakumi; Frank M LaFerla; Yusaku Nakabeppu
Scientific reports 11 (1) 18377 - 18377 2021/09

Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid.
Saori Hata; Kuniyuki Kano; Kazunori Kikuchi; Shoichi Kinoshita; Yuriko Sobu; Haruka Saito; Takashi Saito; Takaomi C Saido; Yoshitake Sano; Hidenori Taru; Junken Aoki; Hiroto Komano; Taisuke Tomita; Shunji Natori; Toshiharu Suzuki
Journal of neurochemistry 159 (3) 603 - 617 2021/08 [Refereed]
Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid.Saori Hata; Kuniyuki Kano; Kazunori Kikuchi; Shoichi Kinoshita; Yuriko So...See More
Suppression of amyloid-β secretion from neurons by cis-9, trans-11-octadecadienoic acid, an isomer of conjugated linoleic acid.
Saori Hata; Kuniyuki Kano; Kazunori Kikuchi; Shoichi Kinoshita; Yuriko Sobu; Haruka Saito; Takashi Saito; Takaomi C Saido; Yoshitake Sano; Hidenori Taru; Junken Aoki; Hiroto Komano; Taisuke Tomita; Shunji Natori; Toshiharu Suzuki
Journal of neurochemistry 159 (3) 603 - 617 2021/08 [Refereed]

Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Barbara Bettegazzi; Laura Sebastian Monasor; Serena Bellani; Franca Codazzi; Lisa Michelle Restelli; Alessio Vittorio Colombo; Nikolaus Deigendesch; Stephan Frank; Takashi Saito; Takaomi C Saido; Sven Lammich; Sabina Tahirovic; Fabio Grohovaz; Daniele Zacchetti
Cell death & disease 12 (8) 769 - 769 2021/08 [Refereed]
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.Barbara Bettegazzi; Laura Sebastian Monasor; Serena Bellani; Franca Codazzi; Lisa Michelle Restelli...See More
Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer's disease.
Barbara Bettegazzi; Laura Sebastian Monasor; Serena Bellani; Franca Codazzi; Lisa Michelle Restelli; Alessio Vittorio Colombo; Nikolaus Deigendesch; Stephan Frank; Takashi Saito; Takaomi C Saido; Sven Lammich; Sabina Tahirovic; Fabio Grohovaz; Daniele Zacchetti
Cell death & disease 12 (8) 769 - 769 2021/08 [Refereed]

A 3rd generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.
Kaori Sato; Naoto Watamura; Ryo Fujioka; Naomi Mihira; Misaki Sekiguchi; Kenichi Nagata; Toshio Ohshima; Takashi Saito; Takaomi C Saido; Hiroki Sasaguri
The Journal of biological chemistry 101004 - 101004 2021/07 [Refereed]
A 3rd generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.Kaori Sato; Naoto Watamura; Ryo Fujioka; Naomi Mihira...See More
A 3rd generation mouse model of Alzheimer's disease shows early and increased cored plaque pathology composed of wild-type human amyloid β peptide.
Kaori Sato; Naoto Watamura; Ryo Fujioka; Naomi Mihira; Misaki Sekiguchi; Kenichi Nagata; Toshio Ohshima; Takashi Saito; Takaomi C Saido; Hiroki Sasaguri
The Journal of biological chemistry 101004 - 101004 2021/07 [Refereed]

Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.
Diana P Benitez; Shenyi Jiang; Jack Wood; Rui Wang; Chloe M Hall; Carlijn Peerboom; Natalie Wong; Katie M Stringer; Karina S Vitanova; Victoria C Smith; Dhaval Joshi; Takashi Saito; Takaomi C Saido; John Hardy; Jörg Hanrieder; Bart De Strooper; Dervis A Salih; Takshashila Tripathi; Frances A Edwards; Damian M Cummings
Molecular neurodegeneration 16 (1) 47 - 47 2021/07 [Refereed]
Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.Diana P Benitez; Shenyi Jiang; Jack Wood; Rui Wang; Chloe M Hall; Carlijn Peerboom; Natalie Won...See More
Knock-in models related to Alzheimer's disease: synaptic transmission, plaques and the role of microglia.
Diana P Benitez; Shenyi Jiang; Jack Wood; Rui Wang; Chloe M Hall; Carlijn Peerboom; Natalie Wong; Katie M Stringer; Karina S Vitanova; Victoria C Smith; Dhaval Joshi; Takashi Saito; Takaomi C Saido; John Hardy; Jörg Hanrieder; Bart De Strooper; Dervis A Salih; Takshashila Tripathi; Frances A Edwards; Damian M Cummings
Molecular neurodegeneration 16 (1) 47 - 47 2021/07 [Refereed]

A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the AppNL-F/NL-F knock-in mouse model.
Guianfranco Mazzei; Ryohei Ikegami; Nona Abolhassani; Naoki Haruyama; Kunihiko Sakumi; Takashi Saito; Takaomi C Saido; Yusaku Nakabeppu
Aging cell 20 (8) e13429 2021/07 [Refereed]
A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the AppNL-F/NL-F knock-in mouse model.Guianfranco Mazzei; Ryohei Ikegami; Nona Abolhassani; Naoki Haruyama; Kunihiko...See More
A high-fat diet exacerbates the Alzheimer's disease pathology in the hippocampus of the AppNL-F/NL-F knock-in mouse model.
Guianfranco Mazzei; Ryohei Ikegami; Nona Abolhassani; Naoki Haruyama; Kunihiko Sakumi; Takashi Saito; Takaomi C Saido; Yusaku Nakabeppu
Aging cell 20 (8) e13429 2021/07 [Refereed]

Difference in the malignancy between RAS and GLI1-transformed astrocytes is associated with frequency of p27KIP1-positive cells in xenograft tissues.
Ken Sasai; Kouichi Tabu; Takashi Saito; Yukio Matsuba; Takaomi C Saido; Shinya Tanaka
Pathology, research and practice 223 153465 - 153465 2021/07 [Refereed]
Difference in the malignancy between RAS and GLI1-transformed astrocytes is associated with frequency of p27KIP1-positive cells in xenograft tissues.Ken Sasai; Kouichi Tabu; Takashi Saito; Yukio Matsu...See More
Difference in the malignancy between RAS and GLI1-transformed astrocytes is associated with frequency of p27KIP1-positive cells in xenograft tissues.
Ken Sasai; Kouichi Tabu; Takashi Saito; Yukio Matsuba; Takaomi C Saido; Shinya Tanaka
Pathology, research and practice 223 153465 - 153465 2021/07 [Refereed]

Neuronal Cell Cycle Re-Entry Enhances Neuropathological Features in AppNLF Knock-In Mice.
Tomás Barrett; Katherine A Stangis; Takashi Saito; Takaomi Saido; Kevin H J Park
Journal of Alzheimer's disease : JAD 2021/06 [Refereed]
Neuronal Cell Cycle Re-Entry Enhances Neuropathological Features in AppNLF Knock-In Mice.Tomás Barrett; Katherine A Stangis; Takashi Saito; Takaomi Saido; Kevin H J ParkJournal of Alzheimer's disease ...See More
Neuronal Cell Cycle Re-Entry Enhances Neuropathological Features in AppNLF Knock-In Mice.
Tomás Barrett; Katherine A Stangis; Takashi Saito; Takaomi Saido; Kevin H J Park
Journal of Alzheimer's disease : JAD 2021/06 [Refereed]

Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis.
Yasufumi Sakakibara; Yu Hirota; Kyoko Ibaraki; Kimi Takei; Sachie Chikamatsu; Yoko Tsubokawa; Takashi Saito; Takaomi C Saido; Michiko Sekiya; Koichi M Iijima
Journal of Alzheimer's disease : JAD 82 (4) 1513 - 1530 2021/06 [Refereed]
Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis.Yasufumi Sakakibara; Yu Hirota; Kyoko Ibaraki; Kimi Takei; Sachie Chikamatsu;...See More
Widespread Reduced Density of Noradrenergic Locus Coeruleus Axons in the App Knock-In Mouse Model of Amyloid-β Amyloidosis.
Yasufumi Sakakibara; Yu Hirota; Kyoko Ibaraki; Kimi Takei; Sachie Chikamatsu; Yoko Tsubokawa; Takashi Saito; Takaomi C Saido; Michiko Sekiya; Koichi M Iijima
Journal of Alzheimer's disease : JAD 82 (4) 1513 - 1530 2021/06 [Refereed]

Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.
Risa Takamura; Kotaro Mizuta; Yukiko Sekine; Tanvir Islam; Takashi Saito; Masaaki Sato; Masamichi Ohkura; Junichi Nakai; Toshio Ohshima; Takaomi C Saido; Yasunori Hayashi
The Journal of neuroscience : the official journal of the Society for Neuroscience 41 (24) 5315 - 5329 2021/06 [Refereed]
Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.Risa Takamura; Kotaro Mizuta; Yukiko Sekine; Tanvir Islam; Takashi Saito; Masaaki Sato; Masamichi Ohkura; Juni...See More
Modality-Specific Impairment of Hippocampal CA1 Neurons of Alzheimer's Disease Model Mice.
Risa Takamura; Kotaro Mizuta; Yukiko Sekine; Tanvir Islam; Takashi Saito; Masaaki Sato; Masamichi Ohkura; Junichi Nakai; Toshio Ohshima; Takaomi C Saido; Yasunori Hayashi
The Journal of neuroscience : the official journal of the Society for Neuroscience 41 (24) 5315 - 5329 2021/06 [Refereed]

11C-PIB and 124I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention.
Silvio R Meier; Dag Sehlin; Sahar Roshanbin; Victoria Lim Falk; Takashi Saito; Takaomi C Saido; Ulf Neumann; Johanna Rokka; Jonas Eriksson; Stina Syvanen
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2021/06 [Refereed]
11C-PIB and 124I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention.Silvio R Meier; Dag Sehlin; Sahar Roshanbin; Victoria Lim Falk; Takashi Saito; Takaomi C ...See More
11C-PIB and 124I-antibody PET provide differing estimates of brain amyloid-beta after therapeutic intervention.
Silvio R Meier; Dag Sehlin; Sahar Roshanbin; Victoria Lim Falk; Takashi Saito; Takaomi C Saido; Ulf Neumann; Johanna Rokka; Jonas Eriksson; Stina Syvanen
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2021/06 [Refereed]

Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease.
Yoshihide Nakamura; Takeshi Yamamoto; Xiaojuan Xu; Shigeki Kobayashi; Shinji Tanaka; Masaki Tamitani; Takashi Saito; Takaomi C Saido; Masafumi Yano
Scientific reports 11 (1) 7289 - 7289 2021/03 [Refereed]
Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease.Yoshihide Nakamura; Takeshi Yamamoto; Xiaojuan Xu; Shigeki Kobayashi; Shinji Tanaka; Masa...See More
Enhancing calmodulin binding to ryanodine receptor is crucial to limit neuronal cell loss in Alzheimer disease.
Yoshihide Nakamura; Takeshi Yamamoto; Xiaojuan Xu; Shigeki Kobayashi; Shinji Tanaka; Masaki Tamitani; Takashi Saito; Takaomi C Saido; Masafumi Yano
Scientific reports 11 (1) 7289 - 7289 2021/03 [Refereed]

PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey.
Xiaoyun Zhou; Bin Ji; Chie Seki; Yuji Nagai; Takafumi Minamimoto; Masayuki Fujinaga; Ming-Rong Zhang; Takashi Saito; Takaomi C Saido; Tetsuya Suhara; Yasuyuki Kimura; Makoto Higuchi
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 41 (9) 271678X211004146 - 2422 2021/03 [Refereed]
PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus mon...See More
PET imaging of colony-stimulating factor 1 receptor: A head-to-head comparison of a novel radioligand, 11C-GW2580, and 11C-CPPC, in mouse models of acute and chronic neuroinflammation and a rhesus monkey.
Xiaoyun Zhou; Bin Ji; Chie Seki; Yuji Nagai; Takafumi Minamimoto; Masayuki Fujinaga; Ming-Rong Zhang; Takashi Saito; Takaomi C Saido; Tetsuya Suhara; Yasuyuki Kimura; Makoto Higuchi
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 41 (9) 271678X211004146 - 2422 2021/03 [Refereed]

Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Kevin Clayton; Jean Christophe Delpech; Shawn Herron; Naotoshi Iwahara; Maria Ericsson; Takashi Saito; Takaomi C Saido; Seiko Ikezu; Tsuneya Ikezu
Molecular neurodegeneration 16 (1) 18 - 18 2021/03 [Refereed]
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.Kevin Clayton; Jean Christophe Delpech; Shawn Herron; Naotoshi Iwahara; M...See More
Plaque associated microglia hyper-secrete extracellular vesicles and accelerate tau propagation in a humanized APP mouse model.
Kevin Clayton; Jean Christophe Delpech; Shawn Herron; Naotoshi Iwahara; Maria Ericsson; Takashi Saito; Takaomi C Saido; Seiko Ikezu; Tsuneya Ikezu
Molecular neurodegeneration 16 (1) 18 - 18 2021/03 [Refereed]

Early Identification of Alzheimer's Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters.
Stephanie Sutoko; Akira Masuda; Akihiko Kandori; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Tsukasa Funane
iScience 24 (3) 102198 - 102198 2021/03 [Refereed]
Early Identification of Alzheimer's Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters.Stephanie Sutoko; Akira Masuda; Akihiko Kandori; Hiroki Sas...See More
Early Identification of Alzheimer's Disease in Mouse Models: Application of Deep Neural Network Algorithm to Cognitive Behavioral Parameters.
Stephanie Sutoko; Akira Masuda; Akihiko Kandori; Hiroki Sasaguri; Takashi Saito; Takaomi C Saido; Tsukasa Funane
iScience 24 (3) 102198 - 102198 2021/03 [Refereed]

Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer's Disease.
Ferdous Taslima; Cha-Gyun Jung; Chunyu Zhou; Mona Abdelhamid; Mohammad Abdullah; Tetsuya Goto; Takashi Saito; Takaomi C Saido; Makoto Michikawa
Journal of Alzheimer's disease : JAD 80 (4) 1687 - 1704 2021/03 [Refereed]
Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer's Disease.Ferdous Taslima; Cha-Gyun Jung; Chunyu Zhou; Mona Abdelhamid; Mohammad Abdullah; Tetsuya Goto; Taka...See More
Tooth Loss Induces Memory Impairment and Gliosis in App Knock-In Mouse Models of Alzheimer's Disease.
Ferdous Taslima; Cha-Gyun Jung; Chunyu Zhou; Mona Abdelhamid; Mohammad Abdullah; Tetsuya Goto; Takashi Saito; Takaomi C Saido; Makoto Michikawa
Journal of Alzheimer's disease : JAD 80 (4) 1687 - 1704 2021/03 [Refereed]

Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice.
Payel Kundu; Eileen Ruth S Torres; Keaton Stagaman; Kristin Kasschau; Mariam Okhovat; Sarah Holden; Samantha Ward; Kimberly A Nevonen; Brett A Davis; Takashi Saito; Takaomi C Saido; Lucia Carbone; Thomas J Sharpton; Jacob Raber
Scientific reports 11 (1) 4678 - 4678 2021/02 [Refereed]
Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice.Payel Kundu; Eileen Ruth S Torres; Keaton Stagaman; Kristin Kasschau; Mariam Okhova...See More
Integrated analysis of behavioral, epigenetic, and gut microbiome analyses in AppNL-G-F, AppNL-F, and wild type mice.
Payel Kundu; Eileen Ruth S Torres; Keaton Stagaman; Kristin Kasschau; Mariam Okhovat; Sarah Holden; Samantha Ward; Kimberly A Nevonen; Brett A Davis; Takashi Saito; Takaomi C Saido; Lucia Carbone; Thomas J Sharpton; Jacob Raber
Scientific reports 11 (1) 4678 - 4678 2021/02 [Refereed]

Multi-scale network imaging in a mouse model of amyloidosis.
Nazanin Doostdar; Joseph Airey; Carola I Radulescu; Leire Melgosa-Ecenarro; Nawal Zabouri; Pavlina Pavlidi; Maksym Kopanitsa; Takashi Saito; Takaomi Saido; Samuel J Barnes
Cell calcium 95 102365 - 102365 2021/02 [Refereed]
Multi-scale network imaging in a mouse model of amyloidosis.Nazanin Doostdar; Joseph Airey; Carola I Radulescu; Leire Melgosa-Ecenarro; Nawal Zabouri; Pavlina Pavlidi; Maksym Kopanitsa; Takashi Saito;...See More
Multi-scale network imaging in a mouse model of amyloidosis.
Nazanin Doostdar; Joseph Airey; Carola I Radulescu; Leire Melgosa-Ecenarro; Nawal Zabouri; Pavlina Pavlidi; Maksym Kopanitsa; Takashi Saito; Takaomi Saido; Samuel J Barnes
Cell calcium 95 102365 - 102365 2021/02 [Refereed]

Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.
Masaki Nakano; Yachiyo Mitsuishi; Lei Liu; Naoki Watanabe; Emi Hibino; Saori Hata; Takashi Saito; Takaomi C Saido; Shigeo Murayama; Kensaku Kasuga; Takeshi Ikeuchi; Toshiharu Suzuki; Masaki Nishimura
Journal of Alzheimer's disease : JAD 80 (1) 159 - 174 2021/01 [Refereed]
Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.Masaki Nakano; Yachiyo Mitsuishi; Lei Liu; Naoki Watanabe; Emi Hibino; Saori Hata...See More
Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.
Masaki Nakano; Yachiyo Mitsuishi; Lei Liu; Naoki Watanabe; Emi Hibino; Saori Hata; Takashi Saito; Takaomi C Saido; Shigeo Murayama; Kensaku Kasuga; Takeshi Ikeuchi; Toshiharu Suzuki; Masaki Nishimura
Journal of Alzheimer's disease : JAD 80 (1) 159 - 174 2021/01 [Refereed]

The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.
Marjan Vandenabeele; Lien Veys; Sophie Lemmens; Xavier Hadoux; Géraldine Gelders; Luca Masin; Lutgarde Serneels; Jan Theunis; Takashi Saito; Takaomi C Saido; Murali Jayapala; Patrick De Boever; Bart De Strooper; Ingeborg Stalmans; Peter van Wijngaarden; Lieve Moons; Lies De Groef
Acta neuropathologica communications 9 (1) 6 - 6 2021/01 [Refereed]
The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.Marjan Vandenabeele; Lien Veys; Sophie Lemmens; Xavier Hadoux; Géraldine Gelders; Luca Masin; Lutgarde S...See More
The AppNL-G-F mouse retina is a site for preclinical Alzheimer's disease diagnosis and research.
Marjan Vandenabeele; Lien Veys; Sophie Lemmens; Xavier Hadoux; Géraldine Gelders; Luca Masin; Lutgarde Serneels; Jan Theunis; Takashi Saito; Takaomi C Saido; Murali Jayapala; Patrick De Boever; Bart De Strooper; Ingeborg Stalmans; Peter van Wijngaarden; Lieve Moons; Lies De Groef
Acta neuropathologica communications 9 (1) 6 - 6 2021/01 [Refereed]

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.
Akira Sobue; Okiru Komine; Yuichiro Hara; Fumito Endo; Hiroyuki Mizoguchi; Seiji Watanabe; Shigeo Murayama; Takashi Saito; Takaomi C Saido; Naruhiko Sahara; Makoto Higuchi; Tomoo Ogi; Koji Yamanaka
Acta neuropathologica communications 9 (1) 1 - 1 2021/01 [Refereed]
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.Akira Sobue; Okiru Komine; Yuichiro Hara; Fumito Endo; Hiroyuki Mizoguchi; Seij...See More
Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.
Akira Sobue; Okiru Komine; Yuichiro Hara; Fumito Endo; Hiroyuki Mizoguchi; Seiji Watanabe; Shigeo Murayama; Takashi Saito; Takaomi C Saido; Naruhiko Sahara; Makoto Higuchi; Tomoo Ogi; Koji Yamanaka
Acta neuropathologica communications 9 (1) 1 - 1 2021/01 [Refereed]

MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease.
Yuri Mizuno; Nona Abolhassani; Guianfranco Mazzei; Kunihiko Sakumi; Takashi Saito; Takaomi C Saido; Toshiharu Ninomiya; Toru Iwaki; Ryo Yamasaki; Jun-Ichi Kira; Yusaku Nakabeppu
Oxidative medicine and cellular longevity 2021 8635088 - 8635088 2021 [Refereed]
MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease.Yuri Mizuno; Nona Abolhassani; Guianfranco Mazzei; Kunihiko Sakumi; Takashi Sai...See More
MUTYH Actively Contributes to Microglial Activation and Impaired Neurogenesis in the Pathogenesis of Alzheimer's Disease.
Yuri Mizuno; Nona Abolhassani; Guianfranco Mazzei; Kunihiko Sakumi; Takashi Saito; Takaomi C Saido; Toshiharu Ninomiya; Toru Iwaki; Ryo Yamasaki; Jun-Ichi Kira; Yusaku Nakabeppu
Oxidative medicine and cellular longevity 2021 8635088 - 8635088 2021 [Refereed]

Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor.
Jun Maeda; Takeharu Minamihisamatsu; Masafumi Shimojo; Xiaoyun Zhou; Maiko Ono; Yukio Matsuba; Bin Ji; Hideki Ishii; Masanao Ogawa; Hiroyasu Akatsu; Daita Kaneda; Yoshio Hashizume; John L Robinson; Virginia M-Y Lee; Takashi Saito; Takaomi C Saido; John Q Trojanowski; Ming-Rong Zhang; Tetsuya Suhara; Makoto Higuchi; Naruhiko Sahara
Brain communications 3 (1) fcab011 2021 [Refereed]
Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor.Jun Maeda; Takeharu Minamihisamatsu; Masafumi Shimojo; Xiaoyun Zhou; Maiko Ono; Yukio Matsu...See More
Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor.
Jun Maeda; Takeharu Minamihisamatsu; Masafumi Shimojo; Xiaoyun Zhou; Maiko Ono; Yukio Matsuba; Bin Ji; Hideki Ishii; Masanao Ogawa; Hiroyasu Akatsu; Daita Kaneda; Yoshio Hashizume; John L Robinson; Virginia M-Y Lee; Takashi Saito; Takaomi C Saido; John Q Trojanowski; Ming-Rong Zhang; Tetsuya Suhara; Makoto Higuchi; Naruhiko Sahara
Brain communications 3 (1) fcab011 2021 [Refereed]

A potential defense mechanism against amyloid deposition in cerebellum.
Alam Shahnur; Masaki Nakano; Seiko Ishihara; Nobuto Kakuda; Tomohiro Miyasaka; Hina Uchiyama; Yuuna Shirai; Mohammad Moniruzzaman; Takashi Saito; Takaomi C Saido; Masaki Nishimura; Satoru Funamoto
Biochemical and biophysical research communications 535 25 - 32 2020/12 [Refereed]
A potential defense mechanism against amyloid deposition in cerebellum.Alam Shahnur; Masaki Nakano; Seiko Ishihara; Nobuto Kakuda; Tomohiro Miyasaka; Hina Uchiyama; Yuuna Shirai; Mohammad Moniruzzaman...See More
A potential defense mechanism against amyloid deposition in cerebellum.
Alam Shahnur; Masaki Nakano; Seiko Ishihara; Nobuto Kakuda; Tomohiro Miyasaka; Hina Uchiyama; Yuuna Shirai; Mohammad Moniruzzaman; Takashi Saito; Takaomi C Saido; Masaki Nishimura; Satoru Funamoto
Biochemical and biophysical research communications 535 25 - 32 2020/12 [Refereed]

Early-life stress induces the development of Alzheimer's disease pathology via angiopathy.
Tomoko Tanaka; Shinobu Hirai; Masato Hosokawa; Takashi Saito; Hiroshi Sakuma; Takaomi Saido; Masato Hasegawa; Haruo Okado
Experimental neurology 337 113552 - 113552 2020/12 [Refereed]
Early-life stress induces the development of Alzheimer's disease pathology via angiopathy.Tomoko Tanaka; Shinobu Hirai; Masato Hosokawa; Takashi Saito; Hiroshi Sakuma; Takaomi Saido; Masato Hasegawa; ...See More
Early-life stress induces the development of Alzheimer's disease pathology via angiopathy.
Tomoko Tanaka; Shinobu Hirai; Masato Hosokawa; Takashi Saito; Hiroshi Sakuma; Takaomi Saido; Masato Hasegawa; Haruo Okado
Experimental neurology 337 113552 - 113552 2020/12 [Refereed]

Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Timothy J Hark; Nalini R Rao; Charlotte Castillon; Tamara Basta; Samuel Smukowski; Huan Bao; Arun Upadhyay; Ewa Bomba-Warczak; Toshihiro Nomura; Eileen T O'Toole; Garry P Morgan; Laith Ali; Takashi Saito; Christelle Guillermier; Takaomi C Saido; Matthew L Steinhauser; Michael H B Stowell; Edwin R Chapman; Anis Contractor; Jeffrey N Savas
Cell systems 2020/12 [Refereed]
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.Timothy J Hark; Nalini R Rao; Charlotte Castillon; T...See More
Pulse-Chase Proteomics of the App Knockin Mouse Models of Alzheimer's Disease Reveals that Synaptic Dysfunction Originates in Presynaptic Terminals.
Timothy J Hark; Nalini R Rao; Charlotte Castillon; Tamara Basta; Samuel Smukowski; Huan Bao; Arun Upadhyay; Ewa Bomba-Warczak; Toshihiro Nomura; Eileen T O'Toole; Garry P Morgan; Laith Ali; Takashi Saito; Christelle Guillermier; Takaomi C Saido; Matthew L Steinhauser; Michael H B Stowell; Edwin R Chapman; Anis Contractor; Jeffrey N Savas
Cell systems 2020/12 [Refereed]

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease.
Md Ali Bin Saifullah; Okiru Komine; Yutao Dong; Kazuya Fukumoto; Akira Sobue; Fumito Endo; Takashi Saito; Takaomi C Saido; Koji Yamanaka; Hiroyuki Mizoguchi
Molecular brain 13 (1) 147 - 147 2020/11 [Refereed]
Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease.Md Ali Bin Saifullah; ...See More
Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer's disease.
Md Ali Bin Saifullah; Okiru Komine; Yutao Dong; Kazuya Fukumoto; Akira Sobue; Fumito Endo; Takashi Saito; Takaomi C Saido; Koji Yamanaka; Hiroyuki Mizoguchi
Molecular brain 13 (1) 147 - 147 2020/11 [Refereed]

Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer's Disease.
Hendrik Nieraad; Natasja de Bruin; Olga Arne; Martine C J Hofmann; Mike Schmidt; Takashi Saito; Takaomi C Saido; Robert Gurke; Dominik Schmidt; Uwe Till; Michael J Parnham; Gerd Geisslinger
Nutrients 12 (11) 2020/10 [Refereed]
Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer's Disease.Hendrik Nieraad; Natasja de Bruin; Olga Arne; Martine C J ...See More
Impact of Hyperhomocysteinemia and Different Dietary Interventions on Cognitive Performance in a Knock-in Mouse Model for Alzheimer's Disease.
Hendrik Nieraad; Natasja de Bruin; Olga Arne; Martine C J Hofmann; Mike Schmidt; Takashi Saito; Takaomi C Saido; Robert Gurke; Dominik Schmidt; Uwe Till; Michael J Parnham; Gerd Geisslinger
Nutrients 12 (11) 2020/10 [Refereed]

Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.
Marius Chiasseu; Arman Fesharaki-Zadeh; Takashi Saito; Takaomi C Saido; Stephen M Strittmatter
Neurobiology of disease 145 105059 - 105059 2020/08 [Refereed]
Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.Marius Chiasseu; Arman Fesharaki-Zadeh; Takashi Saito; Taka...See More
Gene-environment interaction promotes Alzheimer's risk as revealed by synergy of repeated mild traumatic brain injury and mouse App knock-in.
Marius Chiasseu; Arman Fesharaki-Zadeh; Takashi Saito; Takaomi C Saido; Stephen M Strittmatter
Neurobiology of disease 145 105059 - 105059 2020/08 [Refereed]

The two faces of synaptic failure in AppNL-G-F knock-in mice.
Amira Latif-Hernandez; Victor Sabanov; Tariq Ahmed; Katleen Craessaerts; Takashi Saito; Takaomi Saido; Detlef Balschun
Alzheimer's research & therapy 12 (1) 100 - 100 2020/08 [Refereed]
The two faces of synaptic failure in AppNL-G-F knock-in mice.Amira Latif-Hernandez; Victor Sabanov; Tariq Ahmed; Katleen Craessaerts; Takashi Saito; Takaomi Saido; Detlef BalschunAlzheimer's research ...See More
The two faces of synaptic failure in AppNL-G-F knock-in mice.
Amira Latif-Hernandez; Victor Sabanov; Tariq Ahmed; Katleen Craessaerts; Takashi Saito; Takaomi Saido; Detlef Balschun
Alzheimer's research & therapy 12 (1) 100 - 100 2020/08 [Refereed]

Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease.
Heechul Jun; Allen Bramian; Shogo Soma; Takashi Saito; Takaomi C Saido; Kei M Igarashi
Neuron 2020/07 [Refereed]
Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease.Heechul Jun; Allen Bramian; Shogo Soma; Takashi Saito; Takaomi C Saido; Kei M IgarashiNeuron 2020/07 [R...See More
Disrupted Place Cell Remapping and Impaired Grid Cells in a Knockin Model of Alzheimer's Disease.
Heechul Jun; Allen Bramian; Shogo Soma; Takashi Saito; Takaomi C Saido; Kei M Igarashi
Neuron 2020/07 [Refereed]

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models.
Laura Sebastian Monasor; Stephan A Müller; Alessio Vittorio Colombo; Gaye Tanrioever; Jasmin König; Stefan Roth; Arthur Liesz; Anna Berghofer; Anke Piechotta; Matthias Prestel; Takashi Saito; Takaomi C Saido; Jochen Herms; Michael Willem; Christian Haass; Stefan F Lichtenthaler; Sabina Tahirovic
eLife 9 2020/06 [Refereed]
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models.Laura Sebastian Monasor; Stephan A Müller; Alessio Vittorio Colombo; Gaye Tanrioever; Jasmin König; Stef...See More
Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models.
Laura Sebastian Monasor; Stephan A Müller; Alessio Vittorio Colombo; Gaye Tanrioever; Jasmin König; Stefan Roth; Arthur Liesz; Anna Berghofer; Anke Piechotta; Matthias Prestel; Takashi Saito; Takaomi C Saido; Jochen Herms; Michael Willem; Christian Haass; Stefan F Lichtenthaler; Sabina Tahirovic
eLife 9 2020/06 [Refereed]

Oral glutathione administration inhibits the oxidative stress and the inflammatory responses in AppNL-G-F/NL-G-F knock-in mice.
Hisanao Izumi; Keita Sato; Kazuhiro Kojima; Takashi Saito; Takaomi C Saido; Kohji Fukunaga
Neuropharmacology 168 108026 - 108026 2020/05 [Refereed]
Oral glutathione administration inhibits the oxidative stress and the inflammatory responses in AppNL-G-F/NL-G-F knock-in mice.Hisanao Izumi; Keita Sato; Kazuhiro Kojima; Takashi Saito; Takaomi C Said...See More
Oral glutathione administration inhibits the oxidative stress and the inflammatory responses in AppNL-G-F/NL-G-F knock-in mice.
Hisanao Izumi; Keita Sato; Kazuhiro Kojima; Takashi Saito; Takaomi C Saido; Kohji Fukunaga
Neuropharmacology 168 108026 - 108026 2020/05 [Refereed]

Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues.
Etsuo A Susaki; Chika Shimizu; Akihiro Kuno; Kazuki Tainaka; Xiang Li; Kengo Nishi; Ken Morishima; Hiroaki Ono; Koji L Ode; Yuki Saeki; Kazunari Miyamichi; Kaoru Isa; Chihiro Yokoyama; Hiroki Kitaura; Masako Ikemura; Tetsuo Ushiku; Yoshihiro Shimizu; Takashi Saito; Takaomi C Saido; Masashi Fukayama; Hirotaka Onoe; Kazushige Touhara; Tadashi Isa; Akiyoshi Kakita; Mitsuhiro Shibayama; Hiroki R Ueda
Nature communications 11 (1) 1982 - 1982 2020/04 [Refereed]
Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues.Etsuo A Susaki; Chika Shimizu; Akihiro Kuno; Kazuki Tainaka; Xiang Li; Kengo Nishi; Ken Morish...See More
Versatile whole-organ/body staining and imaging based on electrolyte-gel properties of biological tissues.
Etsuo A Susaki; Chika Shimizu; Akihiro Kuno; Kazuki Tainaka; Xiang Li; Kengo Nishi; Ken Morishima; Hiroaki Ono; Koji L Ode; Yuki Saeki; Kazunari Miyamichi; Kaoru Isa; Chihiro Yokoyama; Hiroki Kitaura; Masako Ikemura; Tetsuo Ushiku; Yoshihiro Shimizu; Takashi Saito; Takaomi C Saido; Masashi Fukayama; Hirotaka Onoe; Kazushige Touhara; Tadashi Isa; Akiyoshi Kakita; Mitsuhiro Shibayama; Hiroki R Ueda
Nature communications 11 (1) 1982 - 1982 2020/04 [Refereed]

Progressive changes in sleep and its relations to amyloid-β distribution and learning in single App knock-in mice.
Sakura Eri B Maezono; Mika Kanuka; Chika Tatsuzawa; Miho Morita; Taizo Kawano; Mitsuaki Kashiwagi; Pimpimon Nondhalee; Masanori Sakaguchi; Takashi Saito; Takaomi C Saido; Yu Hayashi
eNeuro 7 (2) 2020/04 [Refereed]
Progressive changes in sleep and its relations to amyloid-β distribution and learning in single App knock-in mice.Sakura Eri B Maezono; Mika Kanuka; Chika Tatsuzawa; Miho Morita; Taizo Kawano; Mitsuak...See More
Progressive changes in sleep and its relations to amyloid-β distribution and learning in single App knock-in mice.
Sakura Eri B Maezono; Mika Kanuka; Chika Tatsuzawa; Miho Morita; Taizo Kawano; Mitsuaki Kashiwagi; Pimpimon Nondhalee; Masanori Sakaguchi; Takashi Saito; Takaomi C Saido; Yu Hayashi
eNeuro 7 (2) 2020/04 [Refereed]

Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.
Sophia Schedin-Weiss; Per Nilsson; Anna Sandebring-Matton; Michael Axenhus; Misaki Sekiguchi; Takashi Saito; Bengt Winblad; Takaomi Saido; Lars O Tjernberg
Journal of Alzheimer's disease : JAD 2020/04 [Refereed]
Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.Sophia Schedin-Weiss; Per Nilsson; Anna Sandebring-Matton; Michael...See More
Proteomics Time-Course Study of App Knock-In Mice Reveals Novel Presymptomatic Aβ42-Induced Pathways to Alzheimer's Disease Pathology.
Sophia Schedin-Weiss; Per Nilsson; Anna Sandebring-Matton; Michael Axenhus; Misaki Sekiguchi; Takashi Saito; Bengt Winblad; Takaomi Saido; Lars O Tjernberg
Journal of Alzheimer's disease : JAD 2020/04 [Refereed]

Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice.
Akira Uruno; Daisuke Matsumaru; Rie Ryoke; Ritsumi Saito; Shiori Kadoguchi; Daisuke Saigusa; Takashi Saito; Takaomi C Saido; Ryuta Kawashima; Masayuki Yamamoto
Molecular and cellular biology 40 (6) 0270-7306 2020/02 [Refereed]
Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice.Akira Uruno; Daisuke Matsumaru; Rie Ryoke; Ritsumi Saito; Shiori Kadoguchi; Daisuke Saigusa; Takashi Sa...See More
Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer's Disease Model Mice.
Akira Uruno; Daisuke Matsumaru; Rie Ryoke; Ritsumi Saito; Shiori Kadoguchi; Daisuke Saigusa; Takashi Saito; Takaomi C Saido; Ryuta Kawashima; Masayuki Yamamoto
Molecular and cellular biology 40 (6) 0270-7306 2020/02 [Refereed]

Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
Mitsuru Shinohara; Yoshitaka Tashiro; Motoko Shinohara; Junko Hirokawa; Kaoru Suzuki; Miyuki Onishi-Takeya; Masahiro Mukouzono; Shuko Takeda; Takashi Saito; Akio Fukumori; Takaomi C Saido; Ryuichi Morishita; Naoyuki Sato
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34 (2) 2425 - 2435 0892-6638 2020/02 [Refereed]
Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.Mitsuru Shinohara; Yoshitaka Tashiro; Motoko Shinohara; Junko Hirokawa; Kaoru Suzuki; Miyuki...See More
Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
Mitsuru Shinohara; Yoshitaka Tashiro; Motoko Shinohara; Junko Hirokawa; Kaoru Suzuki; Miyuki Onishi-Takeya; Masahiro Mukouzono; Shuko Takeda; Takashi Saito; Akio Fukumori; Takaomi C Saido; Ryuichi Morishita; Naoyuki Sato
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34 (2) 2425 - 2435 0892-6638 2020/02 [Refereed]

YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.
Hikari Tanaka; Hidenori Homma; Kyota Fujita; Kanoh Kondo; Shingo Yamada; Xiaocen Jin; Masaaki Waragai; Gaku Ohtomo; Atsushi Iwata; Kazuhiko Tagawa; Naoki Atsuta; Masahisa Katsuno; Naoki Tomita; Katsutoshi Furukawa; Yuko Saito; Takashi Saito; Ayaka Ichise; Shinsuke Shibata; Hiroyuki Arai; Takaomi Saido; Marius Sudol; Shin-Ichi Muramatsu; Hideyuki Okano; Elliott J Mufson; Gen Sobue; Shigeo Murayama; Hitoshi Okazawa
Nature communications 11 (1) 507 - 507 2020/01 [Refereed]
YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.Hikari Tanaka; Hidenori Homma; Kyota Fujita; Kanoh Kondo; Shingo Yamada; Xiaocen Jin; Masaaki W...See More
YAP-dependent necrosis occurs in early stages of Alzheimer's disease and regulates mouse model pathology.
Hikari Tanaka; Hidenori Homma; Kyota Fujita; Kanoh Kondo; Shingo Yamada; Xiaocen Jin; Masaaki Waragai; Gaku Ohtomo; Atsushi Iwata; Kazuhiko Tagawa; Naoki Atsuta; Masahisa Katsuno; Naoki Tomita; Katsutoshi Furukawa; Yuko Saito; Takashi Saito; Ayaka Ichise; Shinsuke Shibata; Hiroyuki Arai; Takaomi Saido; Marius Sudol; Shin-Ichi Muramatsu; Hideyuki Okano; Elliott J Mufson; Gen Sobue; Shigeo Murayama; Hitoshi Okazawa
Nature communications 11 (1) 507 - 507 2020/01 [Refereed]

Retinal Thickness Changes Over Time in a Murine AD Model APP NL-F/NL-F .
Elena Salobrar-García; Inés López-Cuenca; Lídia Sánchez-Puebla; Rosa de Hoz; José A Fernández-Albarral; Ana I Ramírez; Isabel Bravo-Ferrer; Violeta Medina; María A Moro; Takaomi C Saido; Takashi Saito; Juan J Salazar; José M Ramírez
Frontiers in aging neuroscience 12 625642 - 625642 2020 [Refereed]
Retinal Thickness Changes Over Time in a Murine AD Model APP NL-F/NL-F .Elena Salobrar-García; Inés López-Cuenca; Lídia Sánchez-Puebla; Rosa de Hoz; José A Fernández-Albarral; Ana I Ramírez; Isabel Br...See More
Retinal Thickness Changes Over Time in a Murine AD Model APP NL-F/NL-F .
Elena Salobrar-García; Inés López-Cuenca; Lídia Sánchez-Puebla; Rosa de Hoz; José A Fernández-Albarral; Ana I Ramírez; Isabel Bravo-Ferrer; Violeta Medina; María A Moro; Takaomi C Saido; Takashi Saito; Juan J Salazar; José M Ramírez
Frontiers in aging neuroscience 12 625642 - 625642 2020 [Refereed]

Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology.
Silvia de Vidania; Irene Palomares-Perez; Ana Frank-García; Takashi Saito; Takaomi C Saido; Jonathan Draffin; María Szaruga; Lucía Chávez-Gutierrez; Miguel Calero; Miguel Medina; Francesc X Guix; Carlos G Dotti
Frontiers in neuroscience 14 562581 - 562581 2020 [Refereed]
Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology.Silvia de Vidania; Irene Palomares-Perez; Ana Frank-García; Takashi Saito; Taka...See More
Prodromal Alzheimer's Disease: Constitutive Upregulation of Neuroglobin Prevents the Initiation of Alzheimer's Pathology.
Silvia de Vidania; Irene Palomares-Perez; Ana Frank-García; Takashi Saito; Takaomi C Saido; Jonathan Draffin; María Szaruga; Lucía Chávez-Gutierrez; Miguel Calero; Miguel Medina; Francesc X Guix; Carlos G Dotti
Frontiers in neuroscience 14 562581 - 562581 2020 [Refereed]

Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease.
Masataka Narukawa; Suzuka Takahashi; Takashi Saito; Takaomi C Saido; Takumi Misaka
Journal of Alzheimer's disease : JAD 76 (3) 997 - 1004 2020 [Refereed]
Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease.Masataka Narukawa; Suzuka Takahashi; Takashi Saito; Takaomi C Saido; Takumi MisakaJournal of Alzheimer's disease : JA...See More
Analysis of Taste Sensitivities in App Knock-In Mouse Model of Alzheimer's Disease.
Masataka Narukawa; Suzuka Takahashi; Takashi Saito; Takaomi C Saido; Takumi Misaka
Journal of Alzheimer's disease : JAD 76 (3) 997 - 1004 2020 [Refereed]

Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.
Katalin E Sos; Márton I Mayer; Virág T Takács; Abel Major; Zsuzsanna Bardóczi; Barnabas M Beres; Tamás Szeles; Takashi Saito; Takaomi C Saido; István Mody; Tamás F Freund; Gábor Nyiri
PloS one 15 (5) e0233700 2020 [Refereed]
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.Katalin E Sos; Márton I Mayer; Virág T Takács; Abel Major; Zsuzsanna Bardóczi; Barnabas M Beres; Tamás Szeles; Takashi...See More
Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.
Katalin E Sos; Márton I Mayer; Virág T Takács; Abel Major; Zsuzsanna Bardóczi; Barnabas M Beres; Tamás Szeles; Takashi Saito; Takaomi C Saido; István Mody; Tamás F Freund; Gábor Nyiri
PloS one 15 (5) e0233700 2020 [Refereed]

Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice.
Nobuko Hongo; Yusaku Takamura; Hiroshi Nishimaru; Jumpei Matsumoto; Kazuyuki Tobe; Takashi Saito; Takaomi C Saido; Hisao Nishijo
Frontiers in pharmacology 11 307 - 307 2020 [Refereed]
Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice.Nobuko Hongo; Yusaku Takamura; Hiroshi...See More
Astaxanthin Ameliorated Parvalbumin-Positive Neuron Deficits and Alzheimer's Disease-Related Pathological Progression in the Hippocampus of AppNL-G-F/NL-G-F Mice.
Nobuko Hongo; Yusaku Takamura; Hiroshi Nishimaru; Jumpei Matsumoto; Kazuyuki Tobe; Takashi Saito; Takaomi C Saido; Hisao Nishijo
Frontiers in pharmacology 11 307 - 307 2020 [Refereed]

β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.
Zhang F; Gannon M; Chen Y; Yan S; Zhang S; Feng W; Tao J; Sha B; Liu Z; Saito T; Saido T; Keene CD; Jiao K; Roberson ED; Xu H; Wang Q
Science translational medicine 12 (526) 1946-6234 2020/01 [Refereed]
β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.Zhang F; Gannon M; Chen Y; Yan S; Zhang S; Feng W; Tao J; Sha B; Liu Z; Saito T; Saido T; Keene CD; Jiao K; Ro...See More
β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade.
Zhang F; Gannon M; Chen Y; Yan S; Zhang S; Feng W; Tao J; Sha B; Liu Z; Saito T; Saido T; Keene CD; Jiao K; Roberson ED; Xu H; Wang Q
Science translational medicine 12 (526) 1946-6234 2020/01 [Refereed]

Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model.
Rice HC; Marcassa G; Chrysidou I; Horré K; Young-Pearse TL; Müller UC; Saito T; Saido TC; Vassar R; de Wit J; De Strooper B
Molecular neurodegeneration 15 (1) 3 2020/01 [Refereed]
Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model.Rice HC; Marcassa G; Chrysidou I; Horré K; Young-Pearse TL; Müller UC; Saito T; Saido TC; Vassar R; ...See More
Contribution of GABAergic interneurons to amyloid-β plaque pathology in an APP knock-in mouse model.
Rice HC; Marcassa G; Chrysidou I; Horré K; Young-Pearse TL; Müller UC; Saito T; Saido TC; Vassar R; de Wit J; De Strooper B
Molecular neurodegeneration 15 (1) 3 2020/01 [Refereed]

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
Aikawa T; Ren Y; Yamazaki Y; Tachibana M; Johnson MR; Anderson CT; Martens YA; Holm ML; Asmann YW; Saito T; Saido TC; Fitzgerald ML; Bu G; Kanekiyo T
Proceedings of the National Academy of Sciences of the United States of America 0027-8424 2019/11 [Refereed]
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.Aikawa T; Ren Y; Yamazaki Y; Tachibana M; Johnson MR; Anderson CT; Martens YA; Holm ML; Asmann YW; Saito T; Saido TC; Fitz...See More
ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.
Aikawa T; Ren Y; Yamazaki Y; Tachibana M; Johnson MR; Anderson CT; Martens YA; Holm ML; Asmann YW; Saito T; Saido TC; Fitzgerald ML; Bu G; Kanekiyo T
Proceedings of the National Academy of Sciences of the United States of America 0027-8424 2019/11 [Refereed]

Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice.
Manocha GD; Floden AM; Miller NM; Smith AJ; Nagamoto-Combs K; Saito T; Saido TC; Combs CK
Neurobiology of aging 81 166 - 176 0197-4580 2019/09 [Refereed]
Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice.Manocha GD; Floden AM; Miller NM; Smith AJ; Nagamoto-Combs K; Saito T; Saido TC; Combs CKNeurobiology of aging 8...See More
Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice.
Manocha GD; Floden AM; Miller NM; Smith AJ; Nagamoto-Combs K; Saito T; Saido TC; Combs CK
Neurobiology of aging 81 166 - 176 0197-4580 2019/09 [Refereed]

Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease.
Caleb AA; Akiyama T; Kimura A; Kimura Y; Takahashi-Jitsuki A; Nakamura H; Makihara H; Masukawa D; Nakabayashi J; Hirano H; Nakamura F; Saito T; Saido T; Goshima Y
Neurobiology of disease 132 104603 - 104603 0969-9961 2019/09 [Refereed]
Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease.Caleb AA; Akiyama T; Kimura A; Kimura Y; Takahashi-...See More
Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with Aβ in a mice model of early-stage Alzheimer's disease.
Caleb AA; Akiyama T; Kimura A; Kimura Y; Takahashi-Jitsuki A; Nakamura H; Makihara H; Masukawa D; Nakabayashi J; Hirano H; Nakamura F; Saito T; Saido T; Goshima Y
Neurobiology of disease 132 104603 - 104603 0969-9961 2019/09 [Refereed]

Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
Wang W; Tanokashira D; Fukui Y; Maruyama M; Kuroiwa C; Saito T; Saido TC; Taguchi A
Nutrients 11 (8) 2019/08 [Refereed]
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.Wang W; Tanokashira D; Fukui Y; Maruyama M; Kuroiwa C; ...See More
Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.
Wang W; Tanokashira D; Fukui Y; Maruyama M; Kuroiwa C; Saito T; Saido TC; Taguchi A
Nutrients 11 (8) 2019/08 [Refereed]

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours.
Pervolaraki E; Hall SP; Foresteire D; Saito T; Saido TC; Whittington MA; Lever C; Dachtler J
Disease models & mechanisms 12 (9) 1754-8403 2019/08 [Refereed]
Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours.Pervolaraki E; Hall SP; Fore...See More
Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and impacts on anxiety-related behaviours.
Pervolaraki E; Hall SP; Foresteire D; Saito T; Saido TC; Whittington MA; Lever C; Dachtler J
Disease models & mechanisms 12 (9) 1754-8403 2019/08 [Refereed]

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules.
Casadomé-Perales Á; Matteis L; Alleva M; Infantes-Rodríguez C; Palomares-Pérez I; Saito T; Saido TC; Esteban JA; Nebreda AR; de la Fuente JM; Dotti CG
Nanomedicine (London, England) 14 (18) 2409 - 2422 1743-5889 2019/08 [Refereed]
Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules.Casadomé-Perales Á; Matteis L; Alleva M; Infantes-Rodríguez C; Palomares-Pérez I; Sait...See More
Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules.
Casadomé-Perales Á; Matteis L; Alleva M; Infantes-Rodríguez C; Palomares-Pérez I; Saito T; Saido TC; Esteban JA; Nebreda AR; de la Fuente JM; Dotti CG
Nanomedicine (London, England) 14 (18) 2409 - 2422 1743-5889 2019/08 [Refereed]

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.
Ni J; Wu Z; Meng J; Saito T; Saido TC; Qing H; Nakanishi H
Journal of neuroinflammation 16 (1) 173 2019/08 [Refereed]
An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.Ni J; Wu Z; Meng J; Saito T; Saido TC; Qing H; ...See More
An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.
Ni J; Wu Z; Meng J; Saito T; Saido TC; Qing H; Nakanishi H
Journal of neuroinflammation 16 (1) 173 2019/08 [Refereed]

An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.
Naotaka Izuo; Kazuma Murakami; Yoshitaka Fujihara; Masahiro Maeda; Takashi Saito; Takaomi C Saido; Kazuhiro Irie; Takahiko Shimizu
Biochemical and biophysical research communications 515 (3) 462 - 467 0006-291X 2019/07 [Refereed]
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.Naotaka Izuo; Kazuma Murakami; Yoshitak...See More
An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.
Naotaka Izuo; Kazuma Murakami; Yoshitaka Fujihara; Masahiro Maeda; Takashi Saito; Takaomi C Saido; Kazuhiro Irie; Takahiko Shimizu
Biochemical and biophysical research communications 515 (3) 462 - 467 0006-291X 2019/07 [Refereed]

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration.
Hashimoto S; Matsuba Y; Kamano N; Mihira N; Sahara N; Takano J; Muramatsu SI; Saido TC; Saito T
Nature communications 10 (1) 2964 - 2964 2019/07 [Refereed]
Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration.Hashimoto S; Matsuba Y; Kamano N; Mihira N; Sahara N; Takano J; Muramatsu SI; Saido TC; Saito TNature communi...See More
Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration.
Hashimoto S; Matsuba Y; Kamano N; Mihira N; Sahara N; Takano J; Muramatsu SI; Saido TC; Saito T
Nature communications 10 (1) 2964 - 2964 2019/07 [Refereed]

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model.
Sacher C; Blume T; Beyer L; Peters F; Eckenweber F; Sgobio C; Deussing M; Albert NL; Unterrainer M; Lindner S; Gildehaus FJ; von Ungern-Sternberg B; Brzak I; Neumann U; Saito T; Saido TC; Bartenstein P; Rominger A; Herms J; Brendel M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 0161-5505 2019/07 [Refereed]
Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model.Sacher C; Blume T; Beyer L; Peters F; Eckenweber F; Sgobio C; Deussing M; Albert NL...See More
Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model.
Sacher C; Blume T; Beyer L; Peters F; Eckenweber F; Sgobio C; Deussing M; Albert NL; Unterrainer M; Lindner S; Gildehaus FJ; von Ungern-Sternberg B; Brzak I; Neumann U; Saito T; Saido TC; Bartenstein P; Rominger A; Herms J; Brendel M
Journal of nuclear medicine : official publication, Society of Nuclear Medicine 0161-5505 2019/07 [Refereed]

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.
Saito T; Mihira N; Matsuba Y; Sasaguri H; Hashimoto S; Narasimhan S; Zhang B; Murayama S; Higuchi M; Lee VMY; Trojanowski JQ; Saido TC
The Journal of biological chemistry 294 (34) 12754 - 12765 0021-9258 2019/07 [Refereed]
Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.Saito T; Mihira N; Matsuba Y; Sasaguri H; Hashimoto S; Narasimhan S; Zhang B; Murayama S; Higu...See More
Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.
Saito T; Mihira N; Matsuba Y; Sasaguri H; Hashimoto S; Narasimhan S; Zhang B; Murayama S; Higuchi M; Lee VMY; Trojanowski JQ; Saido TC
The Journal of biological chemistry 294 (34) 12754 - 12765 0021-9258 2019/07 [Refereed]

Tau binding protein CAPON induces tau aggregation and neurodegeneration.
Hashimoto S; Matsuba Y; Kamano N; Mihira N; Sahara N; Takano J; Muramatsu SI; Saido TC; Saito T
Nature communications 10 (1) 2394 - 2394 2019/06 [Refereed]
Tau binding protein CAPON induces tau aggregation and neurodegeneration.Hashimoto S; Matsuba Y; Kamano N; Mihira N; Sahara N; Takano J; Muramatsu SI; Saido TC; Saito TNature communications 10 (1) 2394...See More
Tau binding protein CAPON induces tau aggregation and neurodegeneration.
Hashimoto S; Matsuba Y; Kamano N; Mihira N; Sahara N; Takano J; Muramatsu SI; Saido TC; Saito T
Nature communications 10 (1) 2394 - 2394 2019/06 [Refereed]

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Nortley R; Korte N; Izquierdo P; Hirunpattarasilp C; Mishra A; Jaunmuktane Z; Kyrargyri V; Pfeiffer T; Khennouf L; Madry C; Gong H; Richard-Loendt A; Huang W; Saito T; Saido TC; Brandner S; Sethi H; Attwell D
Science (New York, N.Y.) 365 (6450) 0036-8075 2019/06 [Refereed]
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.Nortley R; Korte N; Izquierdo P; Hirunpattarasilp C; Mishra A; Jaunmuktane Z; Kyrargyri V; Pfeiffer T;...See More
Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.
Nortley R; Korte N; Izquierdo P; Hirunpattarasilp C; Mishra A; Jaunmuktane Z; Kyrargyri V; Pfeiffer T; Khennouf L; Madry C; Gong H; Richard-Loendt A; Huang W; Saito T; Saido TC; Brandner S; Sethi H; Attwell D
Science (New York, N.Y.) 365 (6450) 0036-8075 2019/06 [Refereed]

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells.
Keiro Shirotani; Yuma Hori; Ryohei Yoshizaki; Eri Higuchi; Marco Colonna; Takashi Saito; Shoko Hashimoto; Takashi Saito; Takaomi C Saido; Nobuhisa Iwata
Scientific reports 9 (1) 7508 - 7508 2019/05 [Refereed]
Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells.Keiro Shirotani; Yuma Hori; Ryohei Yoshizaki; Eri Higuchi; Marco Colonna; Takashi Saito; Shoko Hashimoto; Takashi Saito; Taka...See More
Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells.
Keiro Shirotani; Yuma Hori; Ryohei Yoshizaki; Eri Higuchi; Marco Colonna; Takashi Saito; Shoko Hashimoto; Takashi Saito; Takaomi C Saido; Nobuhisa Iwata
Scientific reports 9 (1) 7508 - 7508 2019/05 [Refereed]

App^{NL-G-F/NL-G-F} mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation.
Hamaguchi T; Tsutsui-Kimura I; Mimura M; Saito T; Saido TC; Tanaka KF
Neurochemistry international 129 104470 - 104470 0197-0186 2019/05 [Refereed]
AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation.Hamaguchi T; Tsutsui-Kimura I; Mimura M; Saito T; Said...See More
App^{NL-G-F/NL-G-F} mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation.
Hamaguchi T; Tsutsui-Kimura I; Mimura M; Saito T; Saido TC; Tanaka KF
Neurochemistry international 129 104470 - 104470 0197-0186 2019/05 [Refereed]

Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease.
Petrache AL; Rajulawalla A; Shi A; Wetzel A; Saito T; Saido TC; Harvey K; Ali AB
Cerebral cortex (New York, N.Y. : 1991) 29 (4) 1834 - 1850 1047-3211 2019/04 [Refereed]
Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease.Petrache AL; Rajulawalla A; Shi A; Wetzel A; Saito T; Saido TC; Har...See More
Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease.
Petrache AL; Rajulawalla A; Shi A; Wetzel A; Saito T; Saido TC; Harvey K; Ali AB
Cerebral cortex (New York, N.Y. : 1991) 29 (4) 1834 - 1850 1047-3211 2019/04 [Refereed]

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice.
Liu Y; Cheng A; Li YJ; Yang Y; Kishimoto Y; Zhang S; Wang Y; Wan R; Raefsky SM; Lu D; Saito T; Saido T; Zhu J; Wu LJ; Mattson MP
Nature communications 10 (1) 1886 2019/04 [Refereed]
SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice.Liu Y; Cheng A; Li YJ; Yang Y; Kishimoto Y; Zhang S; Wang Y; Wan R; Raefsky SM; Lu D...See More
SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice.
Liu Y; Cheng A; Li YJ; Yang Y; Kishimoto Y; Zhang S; Wang Y; Wan R; Raefsky SM; Lu D; Saito T; Saido T; Zhu J; Wu LJ; Mattson MP
Nature communications 10 (1) 1886 2019/04 [Refereed]

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease.
Yasufumi Sakakibara; Michiko Sekiya; Takashi Saito; Takaomi C Saido; Koichi M Iijima
BMC neuroscience 20 (1) 13 - 13 2019/03 [Refereed]
Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease.Yasufumi Sakakibara; Michiko Sekiya; Takashi Saito;...See More
Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease.
Yasufumi Sakakibara; Michiko Sekiya; Takashi Saito; Takaomi C Saido; Koichi M Iijima
BMC neuroscience 20 (1) 13 - 13 2019/03 [Refereed]

Biology of splicing in Alzheimer's disease research.
Nagata K; Saito T; Saido TC; Morihara T
Progress in molecular biology and translational science 168 79 - 84 1877-1173 2019 [Refereed]

Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.
Wang S; Yabuki Y; Matsuo K; Xu J; Izumi H; Sakimura K; Saito T; Saido TC; Fukunaga K
PloS one 14 (1) e0211590 2019 [Refereed]
Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.Wang S; Yabuki Y; Matsuo K; Xu J; Izum...See More
Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.
Wang S; Yabuki Y; Matsuo K; Xu J; Izumi H; Sakimura K; Saito T; Saido TC; Fukunaga K
PloS one 14 (1) e0211590 2019 [Refereed]

Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse.
Yamakage Y; Tsuiji H; Kohno T; Ogino H; Saito T; Saido TC; Hattori M
Biological & pharmaceutical bulletin 42 (3) 354 - 356 0918-6158 2019 [Refereed]
Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse.Yamakage Y; Tsuiji H; Kohno T; Ogino H; Saito T; Saido TC; Hattori MBiological & pharmaceutical bulletin 42 (3) 354 - 356 0918-615...See More
Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse.
Yamakage Y; Tsuiji H; Kohno T; Ogino H; Saito T; Saido TC; Hattori M
Biological & pharmaceutical bulletin 42 (3) 354 - 356 0918-6158 2019 [Refereed]

Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice
Disha Shah; Amira Latif-Hernandez; Bart De Strooper; Takashi Saito; Takaomi Saido; Marleen Verhoye; Rudi D'Hooge; Annemie Van Der Linden
Scientific Reports Nature Publishing Group 8 (1) 6264 2045-2322 2018/12 [Refereed]
Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in miceDisha Shah; Amira Latif-Hernandez; Bart De Strooper; Takashi Sa...See More
Spatial reversal learning defect coincides with hypersynchronous telencephalic BOLD functional connectivity in APPNL-F/NL-F knock-in mice
Disha Shah; Amira Latif-Hernandez; Bart De Strooper; Takashi Saito; Takaomi Saido; Marleen Verhoye; Rudi D'Hooge; Annemie Van Der Linden
Scientific Reports Nature Publishing Group 8 (1) 6264 2045-2322 2018/12 [Refereed]

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology
Kenichi Nagata; Mika Takahashi; Yukio Matsuba; Fumi Okuyama-Uchimura; Kaori Sato; Shoko Hashimoto; Takashi Saito; Takaomi C. Saido
Nature Communications Nature Publishing Group 9 (1) 1800 2041-1723 2018/12 [Refereed]
Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathologyKenichi Nagata; Mika Takahashi; Yukio Matsuba; Fumi Okuyama-Uchimura; Kaori Sato; Shoko ...See More
Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology
Kenichi Nagata; Mika Takahashi; Yukio Matsuba; Fumi Okuyama-Uchimura; Kaori Sato; Shoko Hashimoto; Takashi Saito; Takaomi C. Saido
Nature Communications Nature Publishing Group 9 (1) 1800 2041-1723 2018/12 [Refereed]

Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.
Purro SA; Farrow MA; Linehan J; Nazari T; Thomas DX; Chen Z; Mengel D; Saito T; Saido T; Rudge P; Brandner S; Walsh DM; Collinge J
Nature 564 (7736) 415 - 419 0028-0836 2018/12 [Refereed]
Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.Purro SA; Farrow MA; Linehan J; Nazari T; Thomas DX; Chen Z; Mengel D; Saito T; Saido T; Rudge P; Brandner S; Walsh ...See More
Transmission of amyloid-β protein pathology from cadaveric pituitary growth hormone.
Purro SA; Farrow MA; Linehan J; Nazari T; Thomas DX; Chen Z; Mengel D; Saito T; Saido T; Rudge P; Brandner S; Walsh DM; Collinge J
Nature 564 (7736) 415 - 419 0028-0836 2018/12 [Refereed]

The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology.
Hikari Tanaka; Kanoh Kondo; Xigui Chen; Hidenori Homma; Kazuhiko Tagawa; Aurelian Kerever; Shigeki Aoki; Takashi Saito; Takaomi Saido; Shin-Ichi Muramatsu; Kyota Fujita; Hitoshi Okazawa
Molecular psychiatry 23 (10) 2090 - 2110 1359-4184 2018/10 [Refereed]
The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology.Hikari Tanaka; Kanoh Kondo; Xigui Chen; Hidenori Homma; Kazuhiko Tagawa; Aurelian Kerever; Shigeki Aoki; Takashi Saito; Tak...See More
The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology.
Hikari Tanaka; Kanoh Kondo; Xigui Chen; Hidenori Homma; Kazuhiko Tagawa; Aurelian Kerever; Shigeki Aoki; Takashi Saito; Takaomi Saido; Shin-Ichi Muramatsu; Kyota Fujita; Hitoshi Okazawa
Molecular psychiatry 23 (10) 2090 - 2110 1359-4184 2018/10 [Refereed]

Neuroinflammation in mouse models of Alzheimer's disease
Saito T; Saido TC
Clinical and Experimental Neuroimmunology 9 (4) 211 - 218 2018/09 [Refereed]

Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits.
Mehla J; Deibel SH; Faraji J; Saito T; Saido TC; Mohajerani MH; McDonald RJ
Hippocampus 29 (1) 3 - 14 1050-9631 2018/08 [Refereed]
Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits.Mehla J; Deibel SH; Faraji J; Saito T; Saido TC; Mohajerani MH; McDonald RJHippocam...See More
Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits.
Mehla J; Deibel SH; Faraji J; Saito T; Saido TC; Mohajerani MH; McDonald RJ
Hippocampus 29 (1) 3 - 14 1050-9631 2018/08 [Refereed]

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis.
Yasufumi Sakakibara; Michiko Sekiya; Takashi Saito; Takaomi C Saido; Koichi M Iijima
BMC neuroscience 19 (1) 46 - 46 2018/07 [Refereed]
Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis.Yasufumi Sakakibara; Michiko Sekiya; Takashi Saito; Takaomi C Saido; Koichi M IijimaBMC neuroscience 19 (1) 46 - 46 2...See More
Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis.
Yasufumi Sakakibara; Michiko Sekiya; Takashi Saito; Takaomi C Saido; Koichi M Iijima
BMC neuroscience 19 (1) 46 - 46 2018/07 [Refereed]

Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease.
Swartzlander DB; Propson NE; Roy ER; Saito T; Saido T; Wang B; Zheng H
JCI insight 3 (13) 2018/07 [Refereed]
Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease.Swartzlander DB; Propson NE; Roy ER; Saito T; Saido T; Wang B; Zheng HJCI insight 3 (13) 2...See More
Concurrent cell type-specific isolation and profiling of mouse brains in inflammation and Alzheimer's disease.
Swartzlander DB; Propson NE; Roy ER; Saito T; Saido T; Wang B; Zheng H
JCI insight 3 (13) 2018/07 [Refereed]

Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease.
Chen L; Saito T; Saido TC; Mody I
eNeuro 5 (4) 2018/07 [Refereed]
Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease.Che...See More
Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease.
Chen L; Saito T; Saido TC; Mody I
eNeuro 5 (4) 2018/07 [Refereed]

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.
Hisanao Izumi; Yasuharu Shinoda; Takashi Saito; Takaomi C Saido; Keita Sato; Yasushi Yabuki; Yotaro Matsumoto; Yoshitomi Kanemitsu; Yoshihisa Tomioka; Nona Abolhassani; Yusaku Nakabeppu; Kohji Fukunaga
Neuroscience 377 87 - 97 0306-4522 2018/05 [Refereed]
The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.Hisanao Izumi; Yasuharu Shinoda; Takashi Saito; Takaomi C Saido; Keit...See More
The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.
Hisanao Izumi; Yasuharu Shinoda; Takashi Saito; Takaomi C Saido; Keita Sato; Yasushi Yabuki; Yotaro Matsumoto; Yoshitomi Kanemitsu; Yoshihisa Tomioka; Nona Abolhassani; Yusaku Nakabeppu; Kohji Fukunaga
Neuroscience 377 87 - 97 0306-4522 2018/05 [Refereed]

Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide
Jizhi Ni; Atsuhiko Taniguchi; Shuta Ozawa; Yukiko Hori; Yoichiro Kuninobu; Takashi Saito; Takaomi C. Saido; Taisuke Tomita; Youhei Sohma; Motomu Kanai
Chem Elsevier Inc 4 (4) 807 - 820 2451-9294 2018/04 [Refereed]
Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid PeptideJizhi Ni; Atsuhiko Taniguchi; Shuta Ozawa; Yukiko Hori; Yoichiro Kuninobu; Takashi Saito; Takaomi C. Saido; Taisuke Tomita; Youhe...See More
Near-Infrared Photoactivatable Oxygenation Catalysts of Amyloid Peptide
Jizhi Ni; Atsuhiko Taniguchi; Shuta Ozawa; Yukiko Hori; Yoichiro Kuninobu; Takashi Saito; Takaomi C. Saido; Taisuke Tomita; Youhei Sohma; Motomu Kanai
Chem Elsevier Inc 4 (4) 807 - 820 2451-9294 2018/04 [Refereed]

Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.
Shigeki Moriguchi; Satomi Kita; Masahiro Fukaya; Makoto Osanai; Ryo Inagaki; Yuzuru Sasaki; Hisanao Izumi; Kyoji Horie; Junji Takeda; Takashi Saito; Hiroyuki Sakagami; Takaomi C Saido; Takahiro Iwamoto; Kohji Fukunaga
Neuropharmacology 131 291 - 303 0028-3908 2018/03 [Refereed]
Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.Shigeki Moriguchi; Satomi Kita; Masahiro Fukaya; Makoto Osanai; Ryo Inagaki; Yuzu...See More
Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.
Shigeki Moriguchi; Satomi Kita; Masahiro Fukaya; Makoto Osanai; Ryo Inagaki; Yuzuru Sasaki; Hisanao Izumi; Kyoji Horie; Junji Takeda; Takashi Saito; Hiroyuki Sakagami; Takaomi C Saido; Takahiro Iwamoto; Kohji Fukunaga
Neuropharmacology 131 291 - 303 0028-3908 2018/03 [Refereed]

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
Kiwami Kidana; Takuya Tatebe; Kaori Ito; Norikazu Hara; Akiyoshi Kakita; Takashi Saito; Sho Takatori; Yasuyoshi Ouchi; Takeshi Ikeuchi; Mitsuhiro Makino; Takaomi C Saido; Masahiro Akishita; Takeshi Iwatsubo; Yukiko Hori; Taisuke Tomita
EMBO molecular medicine 10 (3) 1757-4676 2018/03 [Refereed]
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.Kiwami Kidana; Takuya Tatebe; Kaori Ito; Norikazu Hara; Akiyoshi Kakita; Takashi Saito; Sho Takat...See More
Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.
Kiwami Kidana; Takuya Tatebe; Kaori Ito; Norikazu Hara; Akiyoshi Kakita; Takashi Saito; Sho Takatori; Yasuyoshi Ouchi; Takeshi Ikeuchi; Mitsuhiro Makino; Takaomi C Saido; Masahiro Akishita; Takeshi Iwatsubo; Yukiko Hori; Taisuke Tomita
EMBO molecular medicine 10 (3) 1757-4676 2018/03 [Refereed]

Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.
Brown R; Lam AD; Gonzalez-Sulser A; Ying A; Jones M; Chou RC; Tzioras M; Jordan CY; Jedrasiak-Cape I; Hemonnot AL; Abou Jaoude M; Cole AJ; Cash SS; Saito T; Saido T; Ribchester RR; Hashemi K; Oren I
eNeuro 5 (2) 2018/03 [Refereed]
Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.Brown R; Lam AD; Gonzalez-Sulser A; Ying A; Jones M; Chou RC; Tzioras M; Jordan CY; Jedrasiak-Cape I; Hemonnot ...See More
Circadian and Brain State Modulation of Network Hyperexcitability in Alzheimer's Disease.
Brown R; Lam AD; Gonzalez-Sulser A; Ying A; Jones M; Chou RC; Tzioras M; Jordan CY; Jedrasiak-Cape I; Hemonnot AL; Abou Jaoude M; Cole AJ; Cash SS; Saito T; Saido T; Ribchester RR; Hashemi K; Oren I
eNeuro 5 (2) 2018/03 [Refereed]

Istradefylline reduces memory deficits in aging mice with amyloid pathology
Anna G. Orr; Iris Lo; Heike Schumacher; Kaitlyn Ho; Michael Gill; Weikun Guo; Daniel H. Kim; Anthony Knox; Takashi Saito; Takaomi C. Saido; Jeffrey Simms; Carlee Toddes; Xin Wang; Gui-Qiu Yu; Lennart Mucke
Neurobiology of Disease Academic Press Inc. 110 29 - 36 1095-953X 2018/02 [Refereed]
Istradefylline reduces memory deficits in aging mice with amyloid pathologyAnna G. Orr; Iris Lo; Heike Schumacher; Kaitlyn Ho; Michael Gill; Weikun Guo; Daniel H. Kim; Anthony Knox; Takashi Saito; Tak...See More
Istradefylline reduces memory deficits in aging mice with amyloid pathology
Anna G. Orr; Iris Lo; Heike Schumacher; Kaitlyn Ho; Michael Gill; Weikun Guo; Daniel H. Kim; Anthony Knox; Takashi Saito; Takaomi C. Saido; Jeffrey Simms; Carlee Toddes; Xin Wang; Gui-Qiu Yu; Lennart Mucke
Neurobiology of Disease Academic Press Inc. 110 29 - 36 1095-953X 2018/02 [Refereed]

Reduction in open field activity in the absence of memory deficits in the App(NL-G-F) knock-in mouse model of Alzheimer's disease
Lauren S. Whyte; Kim M. Hemsley; Adeline A. Lau; Sofia Hassiotis; Takashi Saito; Takaomi C. Saido; John J. Hopwood; Timothy J. Sargeant
BEHAVIOURAL BRAIN RESEARCH ELSEVIER SCIENCE BV 336 177 - 181 0166-4328 2018/01 [Refereed]
Reduction in open field activity in the absence of memory deficits in the App(NL-G-F) knock-in mouse model of Alzheimer's diseaseLauren S. Whyte; Kim M. Hemsley; Adeline A. Lau; Sofia Hassiotis; Takas...See More
Reduction in open field activity in the absence of memory deficits in the App(NL-G-F) knock-in mouse model of Alzheimer's disease
Lauren S. Whyte; Kim M. Hemsley; Adeline A. Lau; Sofia Hassiotis; Takashi Saito; Takaomi C. Saido; John J. Hopwood; Timothy J. Sargeant
BEHAVIOURAL BRAIN RESEARCH ELSEVIER SCIENCE BV 336 177 - 181 0166-4328 2018/01 [Refereed]

Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm
Shoko Hashimoto; Ayano Ishii; Naoko Kamano; Naoto Watamura; Takashi Saito; Toshio Ohshima; Makoto Yokosuka; Takaomi C. Saido
Journal of Biological Chemistry American Society for Biochemistry and Molecular Biology Inc. 293 (9) 3118 - 3125 1083-351X 2018 [Refereed]
Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigmShoko Hashimoto; Ayano Ishii; Naoko Kamano; Naoto Watamura; Takashi Saito;...See More
Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm
Shoko Hashimoto; Ayano Ishii; Naoko Kamano; Naoto Watamura; Takashi Saito; Toshio Ohshima; Makoto Yokosuka; Takaomi C. Saido
Journal of Biological Chemistry American Society for Biochemistry and Molecular Biology Inc. 293 (9) 3118 - 3125 1083-351X 2018 [Refereed]

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.
Shuo Wang; Yasushi Yabuki; Kazuya Matsuo; Jing Xu; Hisanao Izumi; Kenji Sakimura; Takashi Saito; Takaomi C Saido; Kohji Fukunaga
PloS one 13 (12) e0206986 2018 [Refereed]
T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.Shuo Wang; Yasushi Yabuki; Kazuya Matsuo; Jing Xu;...See More
T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.
Shuo Wang; Yasushi Yabuki; Kazuya Matsuo; Jing Xu; Hisanao Izumi; Kenji Sakimura; Takashi Saito; Takaomi C Saido; Kohji Fukunaga
PloS one 13 (12) e0206986 2018 [Refereed]

Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
Erika Castillo; Julio Leon; Guianfranco Mazzei; Nona Abolhassani; Naoki Haruyama; Takashi Saito; Takaomi Saido; Masaaki Hokama; Toru Iwaki; Tomoyuki Ohara; Toshiharu Ninomiya; Yutaka Kiyohara; Kunihiko Sakumi; Frank M. LaFerla; Yusaku Nakabeppu
SCIENTIFIC REPORTS NATURE PUBLISHING GROUP 7 (1) 17762 2045-2322 2017/12 [Refereed]
Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammationErika Castillo; Julio Leon; Guianfranco ...See More
Comparative profiling of cortical gene expression in Alzheimer's disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
Erika Castillo; Julio Leon; Guianfranco Mazzei; Nona Abolhassani; Naoki Haruyama; Takashi Saito; Takaomi Saido; Masaaki Hokama; Toru Iwaki; Tomoyuki Ohara; Toshiharu Ninomiya; Yutaka Kiyohara; Kunihiko Sakumi; Frank M. LaFerla; Yusaku Nakabeppu
SCIENTIFIC REPORTS NATURE PUBLISHING GROUP 7 (1) 17762 2045-2322 2017/12 [Refereed]

Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APP^NL-G-F mice before prominent plaque deposition.
Latif-Hernandez A; Shah D; Craessaerts K; Saido T; Saito T; De Strooper B; Van der Linden A; D'Hooge R
Behavioural brain research 364 431 - 441 0166-4328 2017/11 [Refereed]
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition.Latif-Hernandez A; Shah D; Craessaerts K; Saido T; Saito T; De...See More
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APP^NL-G-F mice before prominent plaque deposition.
Latif-Hernandez A; Shah D; Craessaerts K; Saido T; Saito T; De Strooper B; Van der Linden A; D'Hooge R
Behavioural brain research 364 431 - 441 0166-4328 2017/11 [Refereed]

APP mouse models for Alzheimer's disease preclinical studies
Hiroki Sasaguri; Per Nilsson; Shoko Hashimoto; Kenichi Nagata; Takashi Saito; Bart De Strooper; John Hardy; Robert Vassar; Bengt Winblad; Takaomi C. Saido
EMBO JOURNAL WILEY 36 (17) 2473 - 2487 0261-4189 2017/09 [Refereed]
APP mouse models for Alzheimer's disease preclinical studiesHiroki Sasaguri; Per Nilsson; Shoko Hashimoto; Kenichi Nagata; Takashi Saito; Bart De Strooper; John Hardy; Robert Vassar; Bengt Winblad; Ta...See More
APP mouse models for Alzheimer's disease preclinical studies
Hiroki Sasaguri; Per Nilsson; Shoko Hashimoto; Kenichi Nagata; Takashi Saito; Bart De Strooper; John Hardy; Robert Vassar; Bengt Winblad; Takaomi C. Saido
EMBO JOURNAL WILEY 36 (17) 2473 - 2487 0261-4189 2017/09 [Refereed]

Time-course global proteome analyses reveal an inverse correlation between A beta burden and immunoglobulin M levels in the APP(NL-F) mouse model of Alzheimer disease
Hansen Wang; Declan Williams; Jennifer Griffin; Takashi Saito; Takaomi C. Saido; Paul E. Fraser; Ekaterina Rogaeva; Gerold Schmitt-Ulms
PLOS ONE PUBLIC LIBRARY SCIENCE 12 (8) e0182844 1932-6203 2017/08 [Refereed]
Time-course global proteome analyses reveal an inverse correlation between A beta burden and immunoglobulin M levels in the APP(NL-F) mouse model of Alzheimer diseaseHansen Wang; Declan Williams; Jenn...See More
Time-course global proteome analyses reveal an inverse correlation between A beta burden and immunoglobulin M levels in the APP(NL-F) mouse model of Alzheimer disease
Hansen Wang; Declan Williams; Jennifer Griffin; Takashi Saito; Takaomi C. Saido; Paul E. Fraser; Ekaterina Rogaeva; Gerold Schmitt-Ulms
PLOS ONE PUBLIC LIBRARY SCIENCE 12 (8) e0182844 1932-6203 2017/08 [Refereed]

Impaired in vivo gamma oscillations in the medial entorhinal cortex of knock-in Alzheimer model
Tomoaki Nakazono; Travis N. Lam; Ayushi Y. Patel; Masashi Kitazawa; Takashi Saito; Takaomi C. Saido; Kei M. Igarashi
Frontiers in Systems Neuroscience Frontiers Media S.A. 11 48 1662-5137 2017/06 [Refereed]
Impaired in vivo gamma oscillations in the medial entorhinal cortex of knock-in Alzheimer modelTomoaki Nakazono; Travis N. Lam; Ayushi Y. Patel; Masashi Kitazawa; Takashi Saito; Takaomi C. Saido; Kei ...See More
Impaired in vivo gamma oscillations in the medial entorhinal cortex of knock-in Alzheimer model
Tomoaki Nakazono; Travis N. Lam; Ayushi Y. Patel; Masashi Kitazawa; Takashi Saito; Takaomi C. Saido; Kei M. Igarashi
Frontiers in Systems Neuroscience Frontiers Media S.A. 11 48 1662-5137 2017/06 [Refereed]

An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody
Mykhailo Y. Batiuk; Filip de Vin; Sandra I. Duque; Chen Li; Takashi Saito; Takaomi Saido; Mark Fiers; T. Grant Belgard; Matthew G. Holt
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 292 (21) 8874 - 8891 0021-9258 2017/05 [Refereed]
An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibodyMykhailo Y. Batiuk; Filip de Vin; Sandra I. Duque; Chen Li; Takashi Saito; Takao...See More
An immunoaffinity-based method for isolating ultrapure adult astrocytes based on ATP1B2 targeting by the ACSA-2 antibody
Mykhailo Y. Batiuk; Filip de Vin; Sandra I. Duque; Chen Li; Takashi Saito; Takaomi Saido; Mark Fiers; T. Grant Belgard; Matthew G. Holt
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 292 (21) 8874 - 8891 0021-9258 2017/05 [Refereed]

Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
Francesc X. Guix; Ragna Sannerud; Fedor Berditchevski; Amaia M. Arranz; Katrien Horre; An Snellinx; Amantha Thathiah; Takaomi Saido; Takashi Saito; Sundaresan Rajesh; Michael Overduin; Samir Kumar-Singh; Enrico Radaelli; Nikky Corthout; Julien Colombelli; Sebastien Tosi; Sebastian Munck; Isabel H. Salas; Wim Annaert; Bart De Strooper
MOLECULAR NEURODEGENERATION BIOMED CENTRAL LTD 12 (1) 25 1750-1326 2017/03 [Refereed]
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragmentsFrancesc X. Guix; Ragna Sannerud; Fedor Berd...See More
Tetraspanin 6: a pivotal protein of the multiple vesicular body determining exosome release and lysosomal degradation of amyloid precursor protein fragments
Francesc X. Guix; Ragna Sannerud; Fedor Berditchevski; Amaia M. Arranz; Katrien Horre; An Snellinx; Amantha Thathiah; Takaomi Saido; Takashi Saito; Sundaresan Rajesh; Michael Overduin; Samir Kumar-Singh; Enrico Radaelli; Nikky Corthout; Julien Colombelli; Sebastien Tosi; Sebastian Munck; Isabel H. Salas; Wim Annaert; Bart De Strooper
MOLECULAR NEURODEGENERATION BIOMED CENTRAL LTD 12 (1) 25 1750-1326 2017/03 [Refereed]

PLD3 gene and processing of APP
Pietro Fazzari; Katrien Horre; Amaia M. Arranz; Carlo Sala Frigerio; Takashi Saito; Takaomi C. Saido; Bart De Strooper
NATURE NATURE PUBLISHING GROUP 541 (7638) E1 - U354 0028-0836 2017/01 [Refereed]
PLD3 gene and processing of APPPietro Fazzari; Katrien Horre; Amaia M. Arranz; Carlo Sala Frigerio; Takashi Saito; Takaomi C. Saido; Bart De StrooperNATURE NATURE PUBLISHING GROUP 541 (7638) E1 - U354...See More
PLD3 gene and processing of APP
Pietro Fazzari; Katrien Horre; Amaia M. Arranz; Carlo Sala Frigerio; Takashi Saito; Takaomi C. Saido; Bart De Strooper
NATURE NATURE PUBLISHING GROUP 541 (7638) E1 - U354 0028-0836 2017/01 [Refereed]

Cognitive deficits in single App knock-in mouse models
Akira Masuda; Yuki Kobayashi; Naomi Kogo; Takashi Saito; Takaomi C. Saido; Shigeyoshi Itohara
NEUROBIOLOGY OF LEARNING AND MEMORY ACADEMIC PRESS INC ELSEVIER SCIENCE 135 73 - 82 1074-7427 2016/11 [Refereed]
Cognitive deficits in single App knock-in mouse modelsAkira Masuda; Yuki Kobayashi; Naomi Kogo; Takashi Saito; Takaomi C. Saido; Shigeyoshi ItoharaNEUROBIOLOGY OF LEARNING AND MEMORY ACADEMIC PRESS IN...See More
Cognitive deficits in single App knock-in mouse models
Akira Masuda; Yuki Kobayashi; Naomi Kogo; Takashi Saito; Takaomi C. Saido; Shigeyoshi Itohara
NEUROBIOLOGY OF LEARNING AND MEMORY ACADEMIC PRESS INC ELSEVIER SCIENCE 135 73 - 82 1074-7427 2016/11 [Refereed]

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression
Takashi Saito; Yukio Matsuba; Naomi Yamazaki; Shoko Hashimoto; Takaomi C. Saido
JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 36 (38) 9933 - 9936 0270-6474 2016/09 [Refereed]
Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin OverexpressionTakashi Saito; Yukio Matsuba; Naomi Yamazaki; Shoko Hashimoto; Takaomi C. SaidoJOURNAL OF NEUROSCIENCE S...See More
Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression
Takashi Saito; Yukio Matsuba; Naomi Yamazaki; Shoko Hashimoto; Takaomi C. Saido
JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 36 (38) 9933 - 9936 0270-6474 2016/09 [Refereed]

HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease
Kyota Fujita; Kazumi Motoki; Kazuhiko Tagawa; Xigui Chen; Hiroshi Hama; Kazuyuki Nakajima; Hidenori Homma; Takuya Tamura; Hirohisa Watanabe; Masahisa Katsuno; Chiemi Matsumi; Masunori Kajikawa; Takashi Saito; Takaomi Saido; Gen Sobue; Atsushi Miyawaki; Hitoshi Okazawa
SCIENTIFIC REPORTS NATURE PUBLISHING GROUP 6 31895 2045-2322 2016/08 [Refereed]
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's diseaseKyota Fujita; Kazumi Motoki; Kazuhiko Tagawa; Xigui Chen; Hiros...See More
HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease
Kyota Fujita; Kazumi Motoki; Kazuhiko Tagawa; Xigui Chen; Hiroshi Hama; Kazuyuki Nakajima; Hidenori Homma; Takuya Tamura; Hirohisa Watanabe; Masahisa Katsuno; Chiemi Matsumi; Masunori Kajikawa; Takashi Saito; Takaomi Saido; Gen Sobue; Atsushi Miyawaki; Hitoshi Okazawa
SCIENTIFIC REPORTS NATURE PUBLISHING GROUP 6 31895 2045-2322 2016/08 [Refereed]

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Ab Peptide Seeds
Sarah Veugelen; Takashi Saito; Takaomi C. Saido; Lucia Chavez-Gutierrez; Bart De Strooper
NEURON CELL PRESS 90 (2) 410 - 416 0896-6273 2016/04 [Refereed]
Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Ab Peptide SeedsSarah Veugelen; Takashi Saito; Takaomi C. Saido; Lucia Chavez-Gutierrez; Bart De StrooperNEURON CELL PRESS 9...See More
Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Ab Peptide Seeds
Sarah Veugelen; Takashi Saito; Takaomi C. Saido; Lucia Chavez-Gutierrez; Bart De Strooper
NEURON CELL PRESS 90 (2) 410 - 416 0896-6273 2016/04 [Refereed]

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions
Yasuhiko Kizuka; Miyako Nakano; Shinobu Kitazume; Takashi Saito; Takaomi C. Saido; Naoyuki Taniguchi
BIOCHEMICAL JOURNAL PORTLAND PRESS LTD 473 (1) 21 - 30 0264-6021 2016/01 [Refereed]
Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditionsYasuhiko Kizuka; Miyako Nakano; Shinobu Kitazume; Takashi Saito; Takaomi C. Saido; Naoyuki TaniguchiBIOCHEMICAL ...See More
Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions
Yasuhiko Kizuka; Miyako Nakano; Shinobu Kitazume; Takashi Saito; Takaomi C. Saido; Naoyuki Taniguchi
BIOCHEMICAL JOURNAL PORTLAND PRESS LTD 473 (1) 21 - 30 0264-6021 2016/01 [Refereed]

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models
Yunhong Huang; Aneta Skwarek-Maruszewska; Katrien Horre; Elke Vandewyer; Leen Wolfs; An Snellinx; Takashi Saito; Enrico Radaelli; Nikky Corthout; Julien Colombelli; Adrian C. Lo; Leen Van Aerschot; Zsuzsanna Callaerts-Vegh; Daniah Trabzuni; Koen Bossers; Joost Verhaagen; Mina Ryten; Sebastian Munck; Rudi D'Hooge; Dick F. Swaab; John Hardy; Takaomi C. Saido; Bart De Strooper; Amantha Thathiah
SCIENCE TRANSLATIONAL MEDICINE AMER ASSOC ADVANCEMENT SCIENCE 7 (309) 309ra164 1946-6234 2015/10 [Refereed]
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse modelsYunhong Huang; Aneta Skwarek-Maruszewska; Katrien Horre; Elke Vandewyer; Leen Wolfs; An Snellinx; ...See More
Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models
Yunhong Huang; Aneta Skwarek-Maruszewska; Katrien Horre; Elke Vandewyer; Leen Wolfs; An Snellinx; Takashi Saito; Enrico Radaelli; Nikky Corthout; Julien Colombelli; Adrian C. Lo; Leen Van Aerschot; Zsuzsanna Callaerts-Vegh; Daniah Trabzuni; Koen Bossers; Joost Verhaagen; Mina Ryten; Sebastian Munck; Rudi D'Hooge; Dick F. Swaab; John Hardy; Takaomi C. Saido; Bart De Strooper; Amantha Thathiah
SCIENCE TRANSLATIONAL MEDICINE AMER ASSOC ADVANCEMENT SCIENCE 7 (309) 309ra164 1946-6234 2015/10 [Refereed]

Sca/eS: an optical clearing palette for biological imaging
Hiroshi Hama; Hiroyuki Hioki; Kana Namiki; Tetsushi Hoshida; Hiroshi Kurokawa; Fumiyoshi Ishidate; Takeshi Kaneko; Takumi Akagi; Takashi Saito; Takaomi Saido; Atsushi Miyawaki
NATURE NEUROSCIENCE NATURE PUBLISHING GROUP 18 (10) 1518 - + 1097-6256 2015/10 [Refereed]
Sca/eS: an optical clearing palette for biological imagingHiroshi Hama; Hiroyuki Hioki; Kana Namiki; Tetsushi Hoshida; Hiroshi Kurokawa; Fumiyoshi Ishidate; Takeshi Kaneko; Takumi Akagi; Takashi Saito...See More
Sca/eS: an optical clearing palette for biological imaging
Hiroshi Hama; Hiroyuki Hioki; Kana Namiki; Tetsushi Hoshida; Hiroshi Kurokawa; Fumiyoshi Ishidate; Takeshi Kaneko; Takumi Akagi; Takashi Saito; Takaomi Saido; Atsushi Miyawaki
NATURE NEUROSCIENCE NATURE PUBLISHING GROUP 18 (10) 1518 - + 1097-6256 2015/10 [Refereed]

Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease
Hua Zhang; Lili Wu; Ekaterina Pchitskaya; Olga Zakharova; Takashi Saito; Takaomi Saido; Ilya Bezprozvanny
JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 35 (39) 13275 - 13286 0270-6474 2015/09 [Refereed]
Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's DiseaseHua Zhang; Lili Wu; Ekaterina Pchitskaya; Olga Zakharova; Takashi ...See More
Neuronal Store-Operated Calcium Entry and Mushroom Spine Loss in Amyloid Precursor Protein Knock-In Mouse Model of Alzheimer's Disease
Hua Zhang; Lili Wu; Ekaterina Pchitskaya; Olga Zakharova; Takashi Saito; Takaomi Saido; Ilya Bezprozvanny
JOURNAL OF NEUROSCIENCE SOC NEUROSCIENCE 35 (39) 13275 - 13286 0270-6474 2015/09 [Refereed]

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Yasuhiko Kizuka; Shinobu Kitazume; Reiko Fujinawa; Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido; Miyako Nakano; Yoshiki Yamaguchi; Yasuhiro Hashimoto; Matthias Staufenbiel; Hiroyuki Hatsuta; Shigeo Murayama; Hiroshi Manya; Tamao Endo; Naoyuki Taniguchi
EMBO Molecular Medicine Blackwell Publishing Ltd 7 (2) 175 - 189 1757-4684 2015/02 [Refereed]
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's diseaseYasuhiko Kizuka; Shinobu Kitazume; Reiko Fujinawa; Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido; Miyako ...See More
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Yasuhiko Kizuka; Shinobu Kitazume; Reiko Fujinawa; Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido; Miyako Nakano; Yoshiki Yamaguchi; Yasuhiro Hashimoto; Matthias Staufenbiel; Hiroyuki Hatsuta; Shigeo Murayama; Hiroshi Manya; Tamao Endo; Naoyuki Taniguchi
EMBO Molecular Medicine Blackwell Publishing Ltd 7 (2) 175 - 189 1757-4684 2015/02 [Refereed]

Autophagy-Related Protein 7 Deficiency in Amyloid beta (A beta) Precursor Protein Transgenic Mice Decreases A beta in the Multivesicular Bodies and Induces A beta Accumulation in the Golgi
Per Nilsson; Misaki Sekiguchi; Takumi Akagi; Shinichi Izumi; Toshihisa Komor; Kelvin Hui; Karin Soergjerd; Motomasa Tanaka; Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido
AMERICAN JOURNAL OF PATHOLOGY ELSEVIER SCIENCE INC 185 (2) 305 - 313 0002-9440 2015/02 [Refereed]
Autophagy-Related Protein 7 Deficiency in Amyloid beta (A beta) Precursor Protein Transgenic Mice Decreases A beta in the Multivesicular Bodies and Induces A beta Accumulation in the GolgiPer Nilsson;...See More
Autophagy-Related Protein 7 Deficiency in Amyloid beta (A beta) Precursor Protein Transgenic Mice Decreases A beta in the Multivesicular Bodies and Induces A beta Accumulation in the Golgi
Per Nilsson; Misaki Sekiguchi; Takumi Akagi; Shinichi Izumi; Toshihisa Komor; Kelvin Hui; Karin Soergjerd; Motomasa Tanaka; Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido
AMERICAN JOURNAL OF PATHOLOGY ELSEVIER SCIENCE INC 185 (2) 305 - 313 0002-9440 2015/02 [Refereed]

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Yasuhiko Kizuka; Shinobu Kitazume; Reiko Fujinawa; Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido; Miyako Nakano; Yoshiki Yamaguchi; Yasuhiro Hashimoto; Matthias Staufenbiel; Hiroyuki Hatsuta; Shigeo Murayama; Hiroshi Manya; Tamao Endo; Naoyuki Taniguchi
EMBO MOLECULAR MEDICINE WILEY 7 (2) 175 - 189 1757-4676 2015/02 [Refereed]
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's diseaseYasuhiko Kizuka; Shinobu Kitazume; Reiko Fujinawa; Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido; Miyako ...See More
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Yasuhiko Kizuka; Shinobu Kitazume; Reiko Fujinawa; Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido; Miyako Nakano; Yoshiki Yamaguchi; Yasuhiro Hashimoto; Matthias Staufenbiel; Hiroyuki Hatsuta; Shigeo Murayama; Hiroshi Manya; Tamao Endo; Naoyuki Taniguchi
EMBO MOLECULAR MEDICINE WILEY 7 (2) 175 - 189 1757-4676 2015/02 [Refereed]

New Mouse Model of Alzheimer's
Per Nilsson; Takashi Saito; Takaomi C. Saido
ACS CHEMICAL NEUROSCIENCE AMER CHEMICAL SOC 5 (7) 499 - 502 1948-7193 2014/07 [Refereed]

Human Prefoldin Inhibits Amyloid-beta (A beta) Fibrillation and Contributes to Formation of Nontoxic A beta Aggregates (vol 52, pg 3532, 2013)
Karin Margareta Soergjerd; Tamotsu Zako; Masafumi Sakono; Peter C. Stirling; Michel R. Leroux; Takashi Saito; Per Nilsson; Misaki Sekimoto; Takaomi C. Saido; Mizuo Maeda
BIOCHEMISTRY AMER CHEMICAL SOC 53 (21) 3520 - 3520 0006-2960 2014/06 [Refereed]
Human Prefoldin Inhibits Amyloid-beta (A beta) Fibrillation and Contributes to Formation of Nontoxic A beta Aggregates (vol 52, pg 3532, 2013)Karin Margareta Soergjerd; Tamotsu Zako; Masafumi Sakono; ...See More
Human Prefoldin Inhibits Amyloid-beta (A beta) Fibrillation and Contributes to Formation of Nontoxic A beta Aggregates (vol 52, pg 3532, 2013)
Karin Margareta Soergjerd; Tamotsu Zako; Masafumi Sakono; Peter C. Stirling; Michel R. Leroux; Takashi Saito; Per Nilsson; Misaki Sekimoto; Takaomi C. Saido; Mizuo Maeda
BIOCHEMISTRY AMER CHEMICAL SOC 53 (21) 3520 - 3520 0006-2960 2014/06 [Refereed]

Single App knock-in mouse models of Alzheimer's disease
Takashi Saito; Yukio Matsuba; Naomi Mihira; Jiro Takano; Per Nilsson; Shigeyoshi Itohara; Nobuhisa Iwata; Takaomi C. Saido
NATURE NEUROSCIENCE NATURE PUBLISHING GROUP 17 (5) 661 - + 1097-6256 2014/05 [Refereed]
Single App knock-in mouse models of Alzheimer's diseaseTakashi Saito; Yukio Matsuba; Naomi Mihira; Jiro Takano; Per Nilsson; Shigeyoshi Itohara; Nobuhisa Iwata; Takaomi C. SaidoNATURE NEUROSCIENCE NAT...See More
Single App knock-in mouse models of Alzheimer's disease
Takashi Saito; Yukio Matsuba; Naomi Mihira; Jiro Takano; Per Nilsson; Shigeyoshi Itohara; Nobuhisa Iwata; Takaomi C. Saido
NATURE NEUROSCIENCE NATURE PUBLISHING GROUP 17 (5) 661 - + 1097-6256 2014/05 [Refereed]

A beta Secretion and Plaque Formation Depend on Autophagy
Per Nilsson; Krishnapriya Loganathan; Misaki Sekiguchi; Yukio Matsuba; Kelvin Hui; Satoshi Tsubuki; Motomasa Tanaka; Nobuhisa Iwata; Takashi Saito; Takaomi C. Saido
CELL REPORTS CELL PRESS 5 (1) 61 - 69 2211-1247 2013/10 [Refereed]
A beta Secretion and Plaque Formation Depend on AutophagyPer Nilsson; Krishnapriya Loganathan; Misaki Sekiguchi; Yukio Matsuba; Kelvin Hui; Satoshi Tsubuki; Motomasa Tanaka; Nobuhisa Iwata; Takashi Sa...See More
A beta Secretion and Plaque Formation Depend on Autophagy
Per Nilsson; Krishnapriya Loganathan; Misaki Sekiguchi; Yukio Matsuba; Kelvin Hui; Satoshi Tsubuki; Motomasa Tanaka; Nobuhisa Iwata; Takashi Saito; Takaomi C. Saido
CELL REPORTS CELL PRESS 5 (1) 61 - 69 2211-1247 2013/10 [Refereed]

Human Prefoldin Inhibits Amyloid-beta (A beta) Fibrillation and Contributes to Formation of Nontoxic A/beta Aggregates
Karin Margareta Soergjerd; Tamotsu Zako; Masafumi Sakono; Peter C. Stirling; Michel R. Leroux; Takashi Saito; Per Nilsson; Misaki Sekimoto; Takaomi C. Saido; Mizuo Maeda
BIOCHEMISTRY AMER CHEMICAL SOC 52 (20) 3532 - 3542 0006-2960 2013/05 [Refereed]
Human Prefoldin Inhibits Amyloid-beta (A beta) Fibrillation and Contributes to Formation of Nontoxic A/beta AggregatesKarin Margareta Soergjerd; Tamotsu Zako; Masafumi Sakono; Peter C. Stirling; Miche...See More
Human Prefoldin Inhibits Amyloid-beta (A beta) Fibrillation and Contributes to Formation of Nontoxic A/beta Aggregates
Karin Margareta Soergjerd; Tamotsu Zako; Masafumi Sakono; Peter C. Stirling; Michel R. Leroux; Takashi Saito; Per Nilsson; Misaki Sekimoto; Takaomi C. Saido; Mizuo Maeda
BIOCHEMISTRY AMER CHEMICAL SOC 52 (20) 3532 - 3542 0006-2960 2013/05 [Refereed]

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
Satoru Funamoto; Toru Sasaki; Seiko Ishihara; Mika Nobuhara; Masaki Nakano; Miho Watanabe-Takahashi; Takashi Saito; Nobuto Kakuda; Tomohiro Miyasaka; Kiyotaka Nishikawa; Takaomi C. Saido; Yasuo Ihara
Nature Communications 4 2529 2041-1723 2013 [Refereed]
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretaseSatoru Funamoto; Toru Sasaki; Seiko Ishihara; Mika Nobuhara; Masaki Nakano; Miho Watanabe-Takahashi; Takashi Sait...See More
Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase
Satoru Funamoto; Toru Sasaki; Seiko Ishihara; Mika Nobuhara; Masaki Nakano; Miho Watanabe-Takahashi; Takashi Saito; Nobuto Kakuda; Tomohiro Miyasaka; Kiyotaka Nishikawa; Takaomi C. Saido; Yasuo Ihara
Nature Communications 4 2529 2041-1723 2013 [Refereed]

Cell surface expression of the major amyloid-beta peptide (Abeta)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase
Kakiya Naomasa; Saito Takashi; Nilsson Per; Matsuba Yukio; Tsubuki Satoshi; Takei Nobuyuki; Nawa Hiroyuki; Saido Takaomi C
J Biol Chem 287 (35) 29362 - 29372 1083-351X 2012/08 [Refereed]
Cell surface expression of the major amyloid-beta peptide (Abeta)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kin...See More
Cell surface expression of the major amyloid-beta peptide (Abeta)-degrading enzyme, neprilysin, depends on phosphorylation by mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (MEK) and dephosphorylation by protein phosphatase
Kakiya Naomasa; Saito Takashi; Nilsson Per; Matsuba Yukio; Tsubuki Satoshi; Takei Nobuyuki; Nawa Hiroyuki; Saido Takaomi C
J Biol Chem 287 (35) 29362 - 29372 1083-351X 2012/08 [Refereed]

Cell Surface Expression of the Major Amyloid-beta Peptide (A beta)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a
Naomasa Kakiya; Takashi Saito; Per Nilsson; Yukio Matsuba; Satoshi Tsubuki; Nobuyuki Takei; Hiroyuki Nawa; Takaomi C. Saido
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 287 (35) 29362 - 29372 0021-9258 2012/08 [Refereed]
Cell Surface Expression of the Major Amyloid-beta Peptide (A beta)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Ki...See More
Cell Surface Expression of the Major Amyloid-beta Peptide (A beta)-degrading Enzyme, Neprilysin, Depends on Phosphorylation by Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase Kinase (MEK) and Dephosphorylation by Protein Phosphatase 1a
Naomasa Kakiya; Takashi Saito; Per Nilsson; Yukio Matsuba; Satoshi Tsubuki; Nobuyuki Takei; Hiroyuki Nawa; Takaomi C. Saido
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 287 (35) 29362 - 29372 0021-9258 2012/08 [Refereed]

Potent amyloidogenicity and pathogenicity of A beta 43
Takashi Saito; Takahiro Suemoto; Nathalie Brouwers; Kristel Sleegers; Satoru Funamoto; Naomi Mihira; Yukio Matsuba; Kazuyuki Yamada; Per Nilsson; Jiro Takano; Masaki Nishimura; Nobuhisa Iwata; Christine Van Broeckhoven; Yasuo Ihara; Takaomi C. Saido
NATURE NEUROSCIENCE NATURE PUBLISHING GROUP 14 (8) 1023 - U120 1097-6256 2011/08 [Refereed]
Potent amyloidogenicity and pathogenicity of A beta 43Takashi Saito; Takahiro Suemoto; Nathalie Brouwers; Kristel Sleegers; Satoru Funamoto; Naomi Mihira; Yukio Matsuba; Kazuyuki Yamada; Per Nilsson; ...See More
Potent amyloidogenicity and pathogenicity of A beta 43
Takashi Saito; Takahiro Suemoto; Nathalie Brouwers; Kristel Sleegers; Satoru Funamoto; Naomi Mihira; Yukio Matsuba; Kazuyuki Yamada; Per Nilsson; Jiro Takano; Masaki Nishimura; Nobuhisa Iwata; Christine Van Broeckhoven; Yasuo Ihara; Takaomi C. Saido
NATURE NEUROSCIENCE NATURE PUBLISHING GROUP 14 (8) 1023 - U120 1097-6256 2011/08 [Refereed]

High Throughput ELISAs to Measure a Unique Glycan on Transferrin in Cerebrospinal Fluid: A Possible Extension toward Alzheimer's Disease Biomarker Development.
Shirotani K; Futakawa S; Nara K; Hoshi K; Saito T; Tohyama Y; Kitazume S; Yuasa T; Miyajima M; Arai H; Kuno A; Narimatsu H; Hashimoto Y
International journal of Alzheimer's disease 2011 352787 2090-8024 2011 [Refereed]
High Throughput ELISAs to Measure a Unique Glycan on Transferrin in Cerebrospinal Fluid: A Possible Extension toward Alzheimer's Disease Biomarker Development.Shirotani K; Futakawa S; Nara K; Hoshi K;...See More
High Throughput ELISAs to Measure a Unique Glycan on Transferrin in Cerebrospinal Fluid: A Possible Extension toward Alzheimer's Disease Biomarker Development.
Shirotani K; Futakawa S; Nara K; Hoshi K; Saito T; Tohyama Y; Kitazume S; Yuasa T; Miyajima M; Arai H; Kuno A; Narimatsu H; Hashimoto Y
International journal of Alzheimer's disease 2011 352787 2090-8024 2011 [Refereed]

Brain Endothelial Cells Produce Amyloid beta from Amyloid Precursor Protein 770 and Preferentially Secrete the O-Glycosylated Form
Shinobu Kitazume; Yuriko Tachida; Masaki Kato; Yoshiki Yamaguchi; Takashi Honda; Yasuhiro Hashimoto; Yoshinao Wada; Takashi Saito; Nobuhisa Iwata; Takaomi Saido; Naoyuki Taniguchi
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 285 (51) 40097 - 40103 0021-9258 2010/12 [Refereed]
Brain Endothelial Cells Produce Amyloid beta from Amyloid Precursor Protein 770 and Preferentially Secrete the O-Glycosylated FormShinobu Kitazume; Yuriko Tachida; Masaki Kato; Yoshiki Yamaguchi; Taka...See More
Brain Endothelial Cells Produce Amyloid beta from Amyloid Precursor Protein 770 and Preferentially Secrete the O-Glycosylated Form
Shinobu Kitazume; Yuriko Tachida; Masaki Kato; Yoshiki Yamaguchi; Takashi Honda; Yasuhiro Hashimoto; Yoshinao Wada; Takashi Saito; Nobuhisa Iwata; Takaomi Saido; Naoyuki Taniguchi
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 285 (51) 40097 - 40103 0021-9258 2010/12 [Refereed]

Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in A beta production
Yuriko Tachida; Kazuhiro Nakagawa; Takashi Saito; Takaomi C. Saido; Takashi Honda; Yuko Saito; Shigeo Murayama; Tamao Endo; Gaku Sakaguchi; Akira Kato; Shinobu Kitazume; Yasuhiro Hashimoto
JOURNAL OF NEUROCHEMISTRY BLACKWELL PUBLISHING 104 (5) 1387 - 1393 0022-3042 2008/03 [Refereed]
Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in A beta productionYuriko Tachida; Kazuhiro Nakagawa; Takashi Saito; Takaomi C. Saido; Takashi Hon...See More
Interleukin-1 beta up-regulates TACE to enhance alpha-cleavage of APP in neurons: resulting decrease in A beta production
Yuriko Tachida; Kazuhiro Nakagawa; Takashi Saito; Takaomi C. Saido; Takashi Honda; Yuko Saito; Shigeo Murayama; Tamao Endo; Gaku Sakaguchi; Akira Kato; Shinobu Kitazume; Yasuhiro Hashimoto
JOURNAL OF NEUROCHEMISTRY BLACKWELL PUBLISHING 104 (5) 1387 - 1393 0022-3042 2008/03 [Refereed]

A secreted type of beta 1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase
Susumu Nakahara; Takashi Saito; Nami Kondo; Kenta Moriwaki; Katsuhisa Noda; Shinji Ihara; Motoko Takahashi; Yoshihito Ide; Jianguo Gu; Hidenori Inohara; Taiichi Katayama; Masaya Tohyama; Takeshi Kubo; Naoyuki Taniguchi; Eiji Miyoshi
FASEB JOURNAL FEDERATION AMER SOC EXP BIOL 20 (14) 2451 - 2459 0892-6638 2006/12 [Refereed]
A secreted type of beta 1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretaseSusumu Nakahara; Takashi Saito; Nami Kondo; Kenta Moriwaki; Katsuhis...See More
A secreted type of beta 1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase
Susumu Nakahara; Takashi Saito; Nami Kondo; Kenta Moriwaki; Katsuhisa Noda; Shinji Ihara; Motoko Takahashi; Yoshihito Ide; Jianguo Gu; Hidenori Inohara; Taiichi Katayama; Masaya Tohyama; Takeshi Kubo; Naoyuki Taniguchi; Eiji Miyoshi
FASEB JOURNAL FEDERATION AMER SOC EXP BIOL 20 (14) 2451 - 2459 0892-6638 2006/12 [Refereed]

A novel angiogenesis inducer, b1, 6-N-Acetylglucosaminyltransferase V (GnT-V), is processed as a secreted enzyme by g-secretase.
Nakahara S; Saito T; Kondo N; Moriwaki K; Noda K; Ihara S; Takahashi M; Ide Y; Gu J; Inohara H; Katayama T; Tohyama M; Kubo T; Taniguchi N; Miyoshi E
FASEB J 2006/06 [Refereed]
A novel angiogenesis inducer, b1, 6-N-Acetylglucosaminyltransferase V (GnT-V), is processed as a secreted enzyme by g-secretase.Nakahara S; Saito T; Kondo N; Moriwaki K; Noda K; Ihara S; Takahashi M; ...See More
A novel angiogenesis inducer, b1, 6-N-Acetylglucosaminyltransferase V (GnT-V), is processed as a secreted enzyme by g-secretase.
Nakahara S; Saito T; Kondo N; Moriwaki K; Noda K; Ihara S; Takahashi M; Ide Y; Gu J; Inohara H; Katayama T; Tohyama M; Kubo T; Taniguchi N; Miyoshi E
FASEB J 2006/06 [Refereed]

[Presymptomatic diagnosis, prevention and therapy].
Iwata N; Higuchi M; Saito T; Saido TC
No to shinkei = Brain and nerve 57 (10) 855 - 866 0006-8969 2005/10 [Refereed]

A novel angiogenesis inducer, GnT-V is processed as a secreted type by g-secretase
Miyoshi E; Nakahara S; Saito T; Kondo N; Noda K; Inohara H; Taniguchi N
2005/04

Somatostatin regulates brain amyloid beta peptide A beta(42) through modulation of proteolytic degradation
T Saito; N Iwata; S Tsubuki; Y Takaki; J Takano; SM Huang; T Suemoto; M Higuchi; TC Saido
NATURE MEDICINE NATURE PUBLISHING GROUP 11 (4) 434 - 439 1078-8956 2005/04 [Refereed]
Somatostatin regulates brain amyloid beta peptide A beta(42) through modulation of proteolytic degradationT Saito; N Iwata; S Tsubuki; Y Takaki; J Takano; SM Huang; T Suemoto; M Higuchi; TC SaidoNATUR...See More
Somatostatin regulates brain amyloid beta peptide A beta(42) through modulation of proteolytic degradation
T Saito; N Iwata; S Tsubuki; Y Takaki; J Takano; SM Huang; T Suemoto; M Higuchi; TC Saido
NATURE MEDICINE NATURE PUBLISHING GROUP 11 (4) 434 - 439 1078-8956 2005/04 [Refereed]

Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism.
Saito T; Takaki Y; Iwata N; Trojanowski J; Saido TC; Science of aging; knowledge environment; SAGE KE; no; pp. PE
Science of aging knowledge environment : SAGE KE 2003 (3) PE1 2003/01 [Refereed]
Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism.Saito T; Takaki Y; Iwata N; Trojanowski J; Saido TC; Science of aging; knowledge environment; SAGE KE; no; pp. P...See More
Alzheimer's disease, neuropeptides, neuropeptidase, and amyloid-beta peptide metabolism.
Saito T; Takaki Y; Iwata N; Trojanowski J; Saido TC; Science of aging; knowledge environment; SAGE KE; no; pp. PE
Science of aging knowledge environment : SAGE KE 2003 (3) PE1 2003/01 [Refereed]

A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation - A novel function of GnT-V distinct from the original glycosyltransferase activity
T Saito; E Miyoshi; K Sasai; N Nakano; H Eguchi; K Honke; N Taniguchi
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 277 (19) 17002 - 17008 0021-9258 2002/05 [Refereed]
A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation - A novel function of GnT-V distinct from the original glycosyltrans...See More
A secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation - A novel function of GnT-V distinct from the original glycosyltransferase activity
T Saito; E Miyoshi; K Sasai; N Nakano; H Eguchi; K Honke; N Taniguchi
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 277 (19) 17002 - 17008 0021-9258 2002/05 [Refereed]

Implication of GnT-V in cancer metastasis: A glycomic approach for identification of a target protein and its unique function as an angiogenic cofactor
N Taniguchi; S Ihara; T Saito; E Miyoshi; Y Ikeda; K Honke
GLYCOCONJUGATE JOURNAL KLUWER ACADEMIC PUBL 18 (11-12) 859 - 865 0282-0080 2001/11 [Refereed]
Implication of GnT-V in cancer metastasis: A glycomic approach for identification of a target protein and its unique function as an angiogenic cofactorN Taniguchi; S Ihara; T Saito; E Miyoshi; Y Ikeda...See More
Implication of GnT-V in cancer metastasis: A glycomic approach for identification of a target protein and its unique function as an angiogenic cofactor
N Taniguchi; S Ihara; T Saito; E Miyoshi; Y Ikeda; K Honke
GLYCOCONJUGATE JOURNAL KLUWER ACADEMIC PUBL 18 (11-12) 859 - 865 0282-0080 2001/11 [Refereed]

Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta 1
T Saito; A Kinoshita; K Yoshiura; Y Makita; K Wakui; K Honke; N Niikawa; N Taniguchi
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 276 (15) 11469 - 11472 0021-9258 2001/04 [Refereed]
Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta ...See More
Domain-specific mutations of a transforming growth factor (TGF)-beta 1 latency-associated peptide cause Camurati-Engelmann disease because of the formation of a constitutively active form of TGF-beta 1
T Saito; A Kinoshita; K Yoshiura; Y Makita; K Wakui; K Honke; N Niikawa; N Taniguchi
JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 276 (15) 11469 - 11472 0021-9258 2001/04 [Refereed]

Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease
A Kinoshita; T Saito; H Tomita; Y Makita; K Yoshida; M Ghadami; K Yamada; S Kondo; S Ikegawa; G Nishimura; Y Fukushima; T Nakagomi; H Saito; T Sugimoto; M Kamegaya; K Hisa; JC Murray; N Taniguchi; N Niikawa; K Yoshiura
NATURE GENETICS NATURE AMERICA INC 26 (1) 19 - 20 1061-4036 2000/09 [Refereed]
Domain-specific mutations in TGFB1 result in Camurati-Engelmann diseaseA Kinoshita; T Saito; H Tomita; Y Makita; K Yoshida; M Ghadami; K Yamada; S Kondo; S Ikegawa; G Nishimura; Y Fukushima; T Nakagom...See More
Domain-specific mutations in TGFB1 result in Camurati-Engelmann disease
A Kinoshita; T Saito; H Tomita; Y Makita; K Yoshida; M Ghadami; K Yamada; S Kondo; S Ikegawa; G Nishimura; Y Fukushima; T Nakagomi; H Saito; T Sugimoto; M Kamegaya; K Hisa; JC Murray; N Taniguchi; N Niikawa; K Yoshiura
NATURE GENETICS NATURE AMERICA INC 26 (1) 19 - 20 1061-4036 2000/09 [Refereed]

Books etc

Chronic Inflammation: Mechanisms and regulation
Takashi Saito (ContributorChronic neuroinflammation underlying pathogenesis of Alzheimer’s disease.)Springer Book 2016/10

Conference Activities & Talks

アルツハイマー病におけるグリア応答と脳内環境
斉藤貴志
第96回日本生化学会 2023/10

Role of glial responses underlying pathogenesis of Alzheimer’s disease [Invited]
斉藤貴志
Stroke-Immunology Meeting 2023(EMBO Workshop) 2023/09

アルツハイマー病の克服を目指して～モデルマウス開発からの応用展開 [Invited]
斉藤貴志
医療薬学フォーラム2023 2023/07

Multifactorial glial responses and their contributions to Alzheimer’s disease (AD) continuum (From accurate pathological modeling to application) [Invited]
斉藤貴志
University of Zurich特別講演 2023/05

Role of glial response underlying pathogenesis of Alzheimer’s disease [Invited]
斉藤貴志
The 1st Fujita International Symposium on Brain Science 2022/11

グリア応答/神経炎症とアルツハイマー病
齊藤貴志
第４０回日本認知症学会 2021/11

アルツハイマー病モデルマウスの開発とその問題点、そして今後の展開 [Invited]
齊藤貴志
第55回日本実験動物技術者協会総会 2021/10

アルツハイマー病の脳内環境を知る [Invited]
齊藤貴志
第73回日本薬理学会西南部会 2020/11

アルツハイマー病病態形成における認識・選別インフラの役割
齊藤貴志
第93回日本生化学会 2020/09

Towards prevention and treatment of Alzheimer's disease
齊藤貴志
第63回日本神経化学会 2020/09

Recognition and communication of glial cells underlying pathogenesis of Alzheimer’s disease [Not invited]
Takashi Saito
第43回日本神経科学会 2020/07

アルツハイマー病の克服を目指して～モデルマウスの開発からの応用展開 [Invited]
斉藤貴志
第68回脳の医学・生物学研究会 2020/02

次世代型アルツハイマー病モデルマウスの開発からの応用展開 [Invited]
斉藤貴志
名古屋市立大学医学会総会特別講演 2019/12

アルツハイマー病の発症機構の解明を目指して [Invited]
斉藤貴志
第3回医・理・工連携みらい会議 2019/11

アルツハイマー病異常タンパク質蓄積病態の伝播モデル [Invited]
斉藤貴志
第41回神経組織培養研究会シンポジウム 2019/11

マウスモデルにおけるAβ, ApoE, タウ [Not invited]
斉藤貴志
第38回日本認知症学会学術集会シンポジウム 2019/11

アルツハイマー病モデルマウスの開発からの応用展開 [Invited]
斉藤貴志
第29回日本医療薬学会年会 2019/11

Neuroinflammation in mouse models of Alzheimer’s disease [Invited]
Takashi Saito
Special Lecture at Munich Center for Neuroscience, Ludwig-Maximilians Universiy, Germanry 2019/03

次世代型アルツハイマー病モデルマウスの有用性とその応用 [Invited]
斉藤貴志
第24回創剤フォーラム若手研究会 2018/09

Neuroinflammation underlying pathogenesis of Alzheimer’s disease [Not invited]
Takashi Saito
第41回日本神経科学会シンポジウム 2018/07

アルツハイマー病研究のこれまでとこれから [Invited]
斉藤貴志
カン研究所特別セミナー 2017/12

アルツハイマー病モデルマウス [Invited]
斉藤貴志
第7回都医学研シンポジウム 2017/11

アルツハイマー病におけるアミロイド仮説とタウ仮説 [Invited]
斉藤貴志
福島県立医大特別講演 2017/10

次世代型アルツハイマー病モデルマウスの開発とその応用 [Not invited]
斉藤貴志
第47回日本神経精神薬理学会シンポジウム 2017/09

アルツハイマー病モデルマウスの創出と応用 [Invited]
斉藤貴志
第60回日本神経化学会大会 2017/09

認知症・アルツハイマー病の基礎研究の現場から [Invited]
斉藤貴志
熊本大学薬学部同窓会・東京支部卒後研修講義 2017/05

グリア病態からみたアルツハイマー病 [Invited]
斉藤貴志
国立長寿医療研究センター研究会 2017/05

アルツハイマー病研究に資するモデルマウスの開発と応用 [Not invited]
斉藤貴志
日本認知症学会・学会賞受賞記念講演 2016/12

Biology of Time: Humanization of entire murine tau gene for a better model of AD [Not invited]
Takashi Saito
2016/11

異分野融合：繋ぐことの大切さ [Invited]
斉藤貴志
熊本県立宇土高等学校平成２８年度創立記念講演 2016/10

次世代型アルツハイマー病モデルマウスの開発 [Invited]
斉藤貴志
第31回日本薬物動態学会年会 2016/10

アミロイドをターゲットとした認知症予防の試み [Invited]
斉藤貴志
第6回日本認知症予防学会学術集会 2016/09

遺伝子改変マウスを用いた認知症の病理メカニズムの解析 [Invited]
斉藤貴志
福島県立医大特別講演 2016/07

Somatostatin receptors regulate brain Aβ levels via the modulation of neprilysin activity
Takashi Saito
The 39th Annual meeting of the Japan Neuroscience Society 2016/07

アルツハイマー病モデルマウスの新展開 [Invited]
斉藤貴志
東北大学脳科学シンポジウム 2015/12

アルツハイマー病病態形成における神経炎症の役割 [Not invited]
斉藤貴志
BMB2015 2015/12

アルツハイマー病研究に資するモデルマウスの開発と応用 [Not invited]
斉藤貴志
日本認知症学会 2015/10

アルツハイマー病研究に資するモデルマウスの開発とその応用 [Invited]
斉藤貴志
東北大学加齢研セミナー 2015/09

アルツハイマー病の予防・治療・診断法の確立を目指して [Invited]
斉藤貴志
九州薬科学研究教育連合主催合宿研修・創薬研究講義 2015/07

アルツハイマー病研究に資するモデルマウスの開発と応用 [Invited]
斉藤貴志
東京都医学総合研究所セミナー 2015/03

アルツハイマー病の予防・治療・早期診断に向けてのブレイクスルー [Invited]
斉藤貴志
大分薬学ネットワーク研究会 2014/10

次世代型アルツハイマー病モデルマウスの開発から応用へ [Invited]
斉藤貴志
東北大学薬学研究科セミナー 2014/04

新規アルツハイマー病モデルの作製と応用 [Not invited]
斉藤貴志
日本薬学会 2014/03

Aβ代謝・蓄積と炎症反応の相互作用の解明 [Not invited]
斉藤貴志
分子イメージング研究戦略推進プログラム成果報告シンポジウム 2014/02

アルツハイマー病の予防・治療・診断法開発のためのブレイクスルー [Invited]
斉藤貴志
関西学院大学特別講演 2013/12

Update of novel type and more relevant model mouse for Alzheimer’s disease [Not invited]
Takashi Saito
Alzheimer’s Association International Conference 2013 2013/07

アルツハイマー病の治療・予防・診断法の確立を目指して [Invited]
斉藤貴志
日本生化学会関東支部会 2013/06

アミロイドβ43によるアルツハイマー病の病態発症・促進機構に関する研究 [Not invited]
斉藤貴志
日本生化学会・奨励賞受賞講演 2012/12

新規APPノックインマウスの作製と応用 [Not invited]
斉藤貴志
日本認知症学会 2012/10

アルツハイマー病を克服するために今後必要なこと [Invited]
斉藤貴志
熊本大学拠点形成研究セミナー 2011/06

Novel type of “knock-in” mouse model for Alzheimer’s disease [Not invited]
Takashi Saito
The 84th Annual meeting of the Japanese pharmacological Society 2011/03

家族性アルツハイマー病変異R278I-Presenilin1がもたらす新知見 [Invited]
斉藤貴志
熊薬若手研究者シンポジウム 2009/10

A new aspect for the prevention and therapeutic strategy for Alzheimer’s disease [Invited]
Takashi Saito
The Global COE Liaison Laboratory Seminar at Kumamoto University 2008/07

アミロイドβ分解を軸としたアルツハイマー病の創薬 [Invited]
斉藤貴志
第1回創薬シンポジウム 2008/02

アミロイドβペプチド分解機構賦活化によるアルツハイマー病への創薬の可能性 [Invited]
斉藤貴志
大阪大学大学院医学系研究科特別講演 2005/05

MISC

アルツハイマー病における炎症と免疫
齊藤貴志炎症と免疫 132- 288 -293 2024/06

ADモデルマウスにおける老人斑検出の最適化
角田伸人; 吉村陸哉; 宮坂知宏; 船本聡; 池川雅哉; 斎藤貴志; 西道隆臣 Dementia Japan 37- (4) 677 -677 2023/10

バンコマイシン投与による腸内細菌叢の攪乱は,脳内のAβ量を増加させる
柳下聡介; 柴田恵; 古野暁子; 小澤裕介; 橋本翔子; 斉藤貴志; 西道隆臣; 若月修二; 荒木敏之 Dementia Japan 37- (4) 705 -705 2023/10

ミクログリアとアミロイド病理に対するTREM2の機能解析
野田明希; 志築岳; 渡辺かおり; 斉藤貴志; 西道隆臣; 城谷圭朗; 岩田修永 Dementia Japan 37- (4) 710 -710 2023/10

Trem2改変アルツハイマー病モデルマウスの作製と解析
城谷圭朗; 野田明希; 志築岳; 渡辺かおり; 斉藤貴志; 西道隆臣; 岩田修永 Dementia Japan 37- (4) 710 -710 2023/10

アデミロイド病理とタウ病理を示す次世代型アルツハイマー病モデル動物の開発と応用「ノックイン」手法によるマウスモデル開発のあゆみと,それらを用いた研究
橋本翔子; 盛戸貴裕; 綿村直人; 永田健一; 松葉由紀夫; 笹栗弘貴; 斉藤貴志; 西道隆臣 Dementia Japan 37- (4) 616 -616 2023/10

アルツハイマー病の動物モデルの現状と今後の展望
眞鍋達也; 斉藤貴志実験医学（増刊） 41- (12) 137 -143 2023/08

ミクログリアによるアミロイドβ貪食の分子機構とその制御
高鳥翔; 惠谷隼; 近江純平; 斉藤貴志; 西道隆臣; 高井俊行; 大和田智彦; 青木淳賢; 富田泰輔 Dementia Japan 37- (4) 2023

第三世代アルツハイマー病モデルマウスを用いた神経細胞一次繊毛動態の解析
斎藤祐見子; 西道隆臣; 斉藤貴志; 小林勇喜日本生化学会大会プログラム・講演要旨集 95回- 3P -414 2022/11

アルツハイマー病脳における脂質代謝関連因子の遺伝子発現解析
川出野絵; 小峯起; 祖父江顕; 斎藤貴志; 西道隆臣; 村山繁雄; 山中宏二老年精神医学雑誌 33- (増刊II) 228 -228 2022/11

カンナビノイド受容体2型によるグリア細胞の活性調節を介した新規AD治療法の開発
祖父江顕; 小峯起; 遠藤史人; 村山繁雄; 斉藤貴志; 西道隆臣; 山中宏二老年精神医学雑誌 33- (増刊II) 254 -255 2022/11

テストステロンはアルツハイマー病モデルマウスにおける神経炎症に影響する
前川華澄; 祖父江顕; 小峯起; 斉藤貴志; 西道隆臣; 山中宏二老年精神医学雑誌 33- (増刊II) 262 -262 2022/11

アルツハイマー病脳における脂質代謝関連因子の遺伝子発現解析
川出野絵; 小峯起; 祖父江顕; 斎藤貴志; 西道隆臣; 村山繁雄; 山中宏二 Dementia Japan 36- (4) 744 -744 2022/10

カンナビノイド受容体2型によるグリア細胞の活性調節を介した新規AD治療法の開発
祖父江顕; 小峯起; 遠藤史人; 村山繁雄; 斉藤貴志; 西道隆臣; 山中宏二 Dementia Japan 36- (4) 756 -756 2022/10

テストステロンはアルツハイマー病モデルマウスにおける神経炎症に影響する
前川華澄; 祖父江顕; 小峯起; 斉藤貴志; 西道隆臣 Dementia Japan 36- (4) 760 -760 2022/10

家族性アルツハイマー病に対するshRNAポリプレックスの多段階治療戦略
井上雅理; 城野博史; 齊藤貴志; 小野寺理沙子; 東大志; 本山敬一日本DDS学会学術集会プログラム予稿集 38回- 127 -127 2022/06

家族性アルツハイマー病に対するshRNAポリプレックスの多段階治療戦略
井上雅理; 城野博史; 齊藤貴志; 小野寺理沙子; 東大志; 本山敬一日本DDS学会学術集会プログラム予稿集 38回- 127 -127 2022/06

シクロデキストリン修飾カチオン性デンドリマー/shRNA複合体を用いた多段階阻害型アルツハイマー病治療薬の開発
井上雅理; 城野博史; 齊藤貴志; 小野寺理沙子; 東大志; 本山敬一日本薬学会年会要旨集 142年会- 27H -pm16S 2022/03

Effects of glutathione loss on the pathological process of Alzheimer’s disease and neurodegeneration
橋本翔子; 松葉由紀夫; 高橋美華; 釜野直子; 綿村直人; 笹栗弘貴; 齊藤貴志; 西道隆臣日本分子生物学会年会プログラム・要旨集(Web) 45th- 2022

アルツハイマー病モデルにおけるアンドロゲン受容体を介した神経炎症調節機構
前川華澄; 祖父江顕; 小峯起; 斉藤貴志; 西道隆臣; 山中宏二 Dementia Japan 35- (4) 610 -610 2021/10

神経細胞が生合成するトランスフェリンはアルツハイマー病マーカーとなる
橋本康弘; 星京香; 菅野真由美; 村上友太; 阿部十也; 村上丈伸; 吉原章王; 宇川義一; 齋藤貴志; 西道隆臣; 松本加奈; 山口芳樹; 古川勝敏; 荒井啓行; 宮嶋雅一; 小川倫弘; 赤津裕康; 橋詰良夫; 本多たかし; 伊藤浩美 Dementia Japan 35- (4) 655 -655 2021/10
神経細胞が生合成するトランスフェリンはアルツハイマー病マーカーとなる橋本康弘; 星京香; 菅野真由美; 村上友太; 阿部十也; 村上丈伸; 吉原章王; 宇川義一; 齋藤貴志; 西道隆臣; 松本加奈; 山口芳樹; 古川勝敏; 荒井啓行; 宮嶋雅一; 小川倫弘; 赤津裕康; 橋詰良夫; 本多たかし; 伊藤浩美 Dementia Japan 35- (4) ...See More
神経細胞が生合成するトランスフェリンはアルツハイマー病マーカーとなる
橋本康弘; 星京香; 菅野真由美; 村上友太; 阿部十也; 村上丈伸; 吉原章王; 宇川義一; 齋藤貴志; 西道隆臣; 松本加奈; 山口芳樹; 古川勝敏; 荒井啓行; 宮嶋雅一; 小川倫弘; 赤津裕康; 橋詰良夫; 本多たかし; 伊藤浩美 Dementia Japan 35- (4) 655 -655 2021/10

アルツハイマー病の病態進行に伴いミクログリアの生理機能が低下する
祖父江顕; 小峯起; 原雄一郎; 遠藤史人; 溝口博之; 渡邊征爾; 村山繁雄; 斉藤貴志; 西道隆臣; 佐原成彦; 樋口真人; 荻朋男; 山中宏二 Dementia Japan 35- (4) 658 -658 2021/10

Hot topic徹底討論タンパク質蓄積病態に影響するファクターとはアルツハイマー病におけるアミロイドβおよびタウ蓄積病態形成とミクログリアの関与
高鳥翔; 井口明優; 木村新伍; 堀由起子; 佐々木純子; 斉藤貴志; 西道隆臣; 池津庸哉; 高井俊行; 佐々木雄彦; 富田泰輔 Dementia Japan 35- (4) 595 -595 2021/10

環境・衛生部会シンポジウム〜多様なストレスに対する生体適応の仕組みと疾患制御〜 KEAP1-NRF2制御系の活性化とアルツハイマー病病態(Nrf2 suppresses oxidative stress and inflammation in App knock-in Alzheimer's disease model mice)
松丸大輔; 宇留野晃; 領家梨恵; 齋藤律水; 門口詩織; 三枝大輔; 斉藤貴志; 西道隆臣; 川島隆太; 山本雅之日本薬学会年会要旨集 141年会- S16 -3 2021/03
環境・衛生部会シンポジウム〜多様なストレスに対する生体適応の仕組みと疾患制御〜 KEAP1-NRF2制御系の活性化とアルツハイマー病病態(Nrf2 suppresses oxidative stress and inflammation in App knock-in Alzheimer's disease model mice)松丸大輔; 宇留野晃; 領家梨恵; 齋藤律水; 門口詩織;...See More
環境・衛生部会シンポジウム〜多様なストレスに対する生体適応の仕組みと疾患制御〜 KEAP1-NRF2制御系の活性化とアルツハイマー病病態(Nrf2 suppresses oxidative stress and inflammation in App knock-in Alzheimer's disease model mice)
松丸大輔; 宇留野晃; 領家梨恵; 齋藤律水; 門口詩織; 三枝大輔; 斉藤貴志; 西道隆臣; 川島隆太; 山本雅之日本薬学会年会要旨集 141年会- S16 -3 2021/03

加齢性脳機能障害における発達期要因の解明
田中智子; 平井志伸; 細川雅人; 細川雅人; 斉藤貴志; 斉藤貴志; 西道隆臣; 佐久間啓; 長谷川成人; 岡戸晴生 Dementia Japan 35- (4) 2021

ミクログリアのカンナビノイド受容体2型を介したアルツハイマー病における神経炎症調節機構について
祖父江顕; 祖父江顕; 小峯起; 遠藤史人; 村山繁雄; 斉藤貴志; 斉藤貴志; 西道隆臣; 山中宏二日本薬理学雑誌 156- (Supplement) 2021

Pathological role of Aβ, Tau, and ApoE: Insight from the mouse models
齊藤貴志 Dementia Japan 35- 18 -25 2021/01

Development and application of the next generation mouse models for Alzheimer's disease
齊藤貴志 Nagoya Medical Journal 56- 247 -254 2020/12

ADにおけるミクログリアのカンナビノイド受容体2型を介した神経炎症調節について
祖父江顕; 小峯起; 遠藤史人; 村山繁雄; 斉藤貴志; 西道隆臣; 山中宏二 Dementia Japan 34- (4) 474 -474 2020/10

アルツハイマー病モデルにおける神経炎症に対する全身炎症が与える影響の検討
下川梨津子; 小峯起; 伊藤綾香; 祖父江顕; 斉藤貴志; 西道隆臣; 菅波孝祥; 山中宏二 Dementia Japan 34- (4) 528 -528 2020/10

MTH1とOGG1の欠損は,APP^NL-G-Fノックイン・アルツハイマー病モデルマウス脳における8-oxoGの蓄積を増加させ,ミクログリオーシスの亢進と抗不安状態を引き起こす
水野裕理; 斉藤貴志; 斉藤貴志; 西道隆臣; 中別府雄作日本分子生物学会年会プログラム・要旨集(Web) 43rd- 2020

加齢性脳機能障害における発達期要因の解明
田中智子; 平井志伸; 細川雅人; 斉藤貴志; 斉藤貴志; 佐久間啓; 西道隆臣; 長谷川正人; 岡戸晴生 Dementia Japan 34- (4) 2020

Appノックインマウスにおける青斑核神経投射とneurovascular couplingの変化の解析
榊原泰史; 茨木京子; 竹井喜美; 斉藤貴志; 西道隆臣; 関谷倫子; 関谷倫子; 飯島浩一; 飯島浩一 Dementia Japan 34- (4) 2020

発達障害原因遺伝子PQBP1はアルツハイマー病態を制御する
田中ひかり; 近藤和; 陳西貴; 田川一彦; Kerever Aurelian; 青木茂樹; 斉藤貴志; 西道隆臣; 村松慎一; 藤田慶大; 岡澤均臨床神経学 59- (Suppl.) S461 -S461 2019/11 [Refereed]

アルツハイマー病患者とAppNL-G-Fマウスにおける神経炎症関連遺伝子解析
祖父江顕; 小峯起; 遠藤史人; 村山繁雄; 斉藤貴志; 西道隆臣; 山中宏二 Dementia Japan 33- (4) 550 -550 2019/10

大脳皮質におけるILEI/FAM3CおよびAβの間質液への分泌様式に関する比較検討
中野将希; 三ツ石弥千代; 渡邊直希; 日比野絵美; 斉藤貴志; 西道隆臣; 鈴木利治; 西村正樹 Dementia Japan 33- (4) 514 -514 2019/10

アルツハイマー病リスク遺伝子INPP5DがTREM2シグナル伝達において果たす役割の解明
井口明優; 高鳥翔; 木村新伍; 佐々木純子; 斉藤貴志; 西道隆臣; 高井俊行; 佐々木雄彦; 富田泰輔 Dementia Japan 33- (4) 551 -551 2019/10

死細胞およびマウス大脳皮質に発現するTREM2リガンド
城谷圭朗; 長田重一; Colonna Marco; 斉藤隆; 橋本翔子; 斉藤貴志; 西道隆臣; 岩田修永 Dementia Japan 33- (4) 522 -522 2019/10

アルツハイマー病患者とAppNL-G-Fマウスにおける神経炎症関連遺伝子解析
祖父江顕; 小峯起; 遠藤史人; 村山繁雄; 斉藤貴志; 西道隆臣; 山中宏二 Dementia Japan 33- (4) 550 -550 2019/10

脳内インフラストラクチャー: 脳細胞社会の恒常性維持機構と物流システムを担う機能的構造体アルツハイマー病遺伝学的リスク因子INPP5Dの病態関与に関する研究
高鳥翔; 井口明優; 木村新伍; 佐々木純子; 佐々木雄彦; 高井俊行; 斉藤貴志; 西道隆臣; 富田泰輔日本生化学会大会プログラム・講演要旨集 92回- [1S17m -05] 2019/09

アミノリン脂質は死細胞上のTREM2リガンドである
城谷圭朗; 長田重一; Collona Marco; 斉藤隆; 橋本翔子; 斉藤貴志; 西道隆臣; 岩田修永日本生化学会大会プログラム・講演要旨集 92回- [2P -353] 2019/09

アルツハイマー病マウスモデルへのp3-Alcβペプチド投与による脳内アミロイドプラーク変化
木下祥一; 齋藤遥; 齊藤貴志; 西道隆臣; 鈴木利治; 羽田沙緒里日本生化学会大会プログラム・講演要旨集 92回- [1P -326] 2019/09

塩基修復酵素,OGG1とMUTYHの欠損はApp^NL-G-Fノックイン・アルツハイマー病モデルマウスにおけるミクログリアの活性化状態と脳内のアミロイドβの沈着および行動様式を変化させる
水野裕理; NONA Abolhassani; GUIANFRANCO Mazzei; 斉藤貴志; 斉藤貴志; 西道隆臣; 中別府雄作日本分子生物学会年会プログラム・要旨集(Web) 42nd- 2019

Characterization of primary cilia in App knock-in mouse models
河渕省吾; 三木大輔; 斉藤貴志; 西道隆臣; 小林勇喜; 斎藤祐見子日本動物学会中国四国支部会報(CD-ROM) (71) 2019

アルツハイマー病の進行に関わる新規タンパク質CAPONの機能解析
橋本翔子; 松葉由紀夫; 釜野直子; 三平尚美; 高野二郎; 佐原成彦; 村松慎一; 斉藤貴志; 西道隆臣 Dementia Japan 33- (4) 2019

間欠的低酸素負荷モデルを用いたリン酸化タウの増加・蓄積のメカニズム解明
柳下聡介; 橋本翔子; 斉藤貴志; 西道隆臣; 荒木敏之 Dementia Japan 33- (4) 2019

神経活動に伴うリン酸化タウの変動およびタウ蓄積のメカニズム解明
柳下聡介; 橋本翔子; 斉藤貴志; 西道隆臣; 荒木敏之日本生化学会大会(Web) 92nd- 2019

アルツハイマー病を促進させる新規タンパク質CAPONの機能解析
橋本翔子; 松葉由紀夫; 釜野直子; 三平尚美; 高野二郎; 佐原成彦; 村松慎一; 斉藤貴志; 西道隆臣日本生化学会大会(Web) 92nd- 2019

ミクログリアに発現する神経変性疾患の危険因子TREM2受容体のリガンドの同定
脇田直樹; 城谷圭朗; 城谷圭朗; 長田重一; COLONNA Marco; 橋本翔子; 斉藤貴志; 西道隆臣; 岩田修永; 岩田修永日本薬学会九州支部大会講演要旨集 36th- 2019

Cognitive deficits and synaptic degeneration in App knock-in mouse models of AD
飯島浩一; 榊原泰史; 斉藤貴志; 西道隆臣; 関谷倫子 Dementia Japan 33- (4) 2019

認知症・アルツハイマー病研究のいま
斉藤貴志九州薬学会雑誌 72- 1 -5 2018/12 [Invited]

ピログルタミル化
斉藤貴志; 西道隆臣生体の科学 69- 474 -475 2018/12 [Invited]

アルツハイマー病モデルマウス海馬CA1領域における神経機能回路の段階的破綻
高村理沙; 水田恒太郎; 関根友紀子; イスラム・タンビル; 斉藤貴志; 竹川高志; 大倉正道; 深井朋樹; 中井淳一; 大島登志男; 西道隆臣; 林康紀 Dementia Japan 32- (3) 415 -415 2018/09

認知症の増悪に関わる脳アミロイドアンギオパチーモデル動物を用いた治療標的探索
北爪しのぶ; 今牧理恵; 立田由里子; 木塚康彦; 斎藤貴志; 西道隆臣; 佐原成彦; 冨本秀和; 谷口直之 Dementia Japan 32- (3) 426 -426 2018/09

加齢性脳機能障害における発達期要因の解明
田中智子; 細川雅人; 斉藤貴志; 西道隆臣; 長谷川成人; 岡戸晴生 Dementia Japan 32- (3) 2018

次世代型アルツハイマーモデルマウス(APP-KI)における酸化ストレスの検討
本江信子; 高村雄策; 西丸広史; 松本惇平; 戸邉一之; 齊藤貴志; 西道隆臣; 小野武年; 西条寿夫日本生理学雑誌(Web) 80- (1) 2018

アルツハイマー病モデルマウスにおける小胞体ストレス応答(過剰発現VSノックイン)
石井綾乃; 石井綾乃; 橋本翔子; 釜野直子; 綿村直人; 綿村直人; 斉藤貴志; 大島登志男; 横須賀誠; 西道隆臣 Dementia Japan 32- (3) 2018

KEAP1‐NRF2制御系の活性化はアルツハイマー病様病態を改善する
松丸大輔; 領家梨恵; 齋藤律水; 三枝大輔; 齊藤貴志; 西道隆臣; 川島隆太; 山本雅之; 山本雅之; 宇留野晃; 宇留野晃; 本橋ほづみ日本生化学会大会(Web) 91st- ROMBUNNO.3P‐285 (WEB ONLY) -285] 2018

糖鎖修飾と、末梢組織から見た神経系疾患アルツハイマー病態をコントロールする糖鎖修飾
北爪しのぶ[川口]; 木塚康彦; 立田由里子; 今牧理恵; 斉藤貴志; 西道隆臣; 谷口直之生命科学系学会合同年次大会 2017年度- [1AW27 -2] 2017/12

脳アミロイドアンギオパチーを示す新規モデルマウスの開発
北爪しのぶ; 今牧理恵; 立田由里子; 木塚康彦; 佐原成彦; 冨本秀和; 斉藤貴志; 西道隆臣; 谷口直之 Dementia Japan 31- (4) 565 -565 2017/10

糖尿病に伴う脳インスリン様シグナル変容がアルツハイマー病態に与える影響
田之頭大輔; 徳永暁憲; 多田敬典; 佐治多美子; 柏田舞波; 竹井喜美; 今井萌乃; 斉藤貴志; 西道隆臣; 田口明子 Dementia Japan 31- (4) 574 -574 2017/10

次世代型ADモデル動物がもたらすAD病態の新知見 (特集アルツハイマー病の次世代診断・治療に向けた新知見)
斉藤貴志; 西道隆臣分子精神医学 17- (2) 85 -91 2017/04

グルタチオン量減少がアルツハイマー病病理に及ぼす影響の解析
橋本翔子; 釜野直子; 石井綾乃; 斉藤貴志; 西道隆臣日本生化学会大会(Web) 90th- 2017

新規アルツハイマー病関連因子による神経変性メカニズムの解明
橋本翔子; 釜野直子; 松葉由紀夫; 村松慎一; 斉藤貴志; 西道隆臣 Dementia Japan 31- (4) 2017

光酸素化反応系を用いた酸素化Aβの生化学的解析
小澤柊太; 谷口敦彦; 谷口敦彦; 谷口敦彦; 清水裕介; 城野柳人; 斉藤貴志; 西道隆臣; 相馬洋平; 相馬洋平; 堀由起子; 金井求; 金井求; 富田泰輔 Dementia Japan 31- (4) 2017

in vivoにおける光酸素化反応系により酸素化されたAβの生化学的解析
小澤柊太; 谷口敦彦; 谷口敦彦; 谷口敦彦; 城野柳人; 齊藤貴志; 西道隆臣; 相馬洋平; 相馬洋平; 堀由起子; 金井求; 金井求; 富田泰輔日本薬学会年会要旨集(CD-ROM) 137th- 2017

アストロサイト由来アミロイドβ分解酵素KLK7の発現制御機構の解明
建部卓也; 建部卓也; 木棚究; 堀由起子; 斉藤貴志; 西道隆臣; 富田泰輔日本生化学会大会(Web) 90th- 2017

光酸素化反応系を用いた酸素化Aβの生化学的解析
堀由起子; 小澤柊太; 谷口敦彦; 谷口敦彦; 谷口敦彦; 清水裕介; 城野柳人; 斉藤貴志; 西道隆臣; 相馬洋平; 相馬洋平; 金井求; 金井求; 富田泰輔メディシナルケミストリーシンポジウム講演要旨集 35th- 2017

ADモデルマウスの開発と応用
斉藤貴志実験医学増刊「認知症」 35- 130 -134 2017 [Invited]

次世代型ADモデル動物がもたらすAD病態の新知見
斉藤貴志分子精神医学 17- 21 -27 2017 [Invited]

透明化技術Scaleによる神経組織の探索
濱裕; 日置寛之; 並木香奈; 星田哲志; 黒川裕; 斉藤貴志; 西道隆臣; 宮脇敦史 Dementia Japan 30- (4) 490 2016/10

アルツハイマー病リスク遺伝子INPP5Dの機能解明
木村新伍; 高鳥翔; 堀由起子; 佐々木純子; 佐々木雄彦; 斉藤貴志; 西道隆臣; 富田泰輔 Dementia Japan 30- (4) 564 -564 2016/10

グルタチオン量減少がアルツハイマー病病理に及ぼす影響の解析
橋本翔子; 斉藤貴志; 西道隆臣 Dementia Japan 30- (4) 2016

アストロサイト由来新規Aβ分解酵素KLK7の病的機能解明
建部卓也; 木棚究; 菊池一徳; 斉藤貴志; 大内尉義; 秋下雅弘; 西道隆臣; 岩坪威; 富田泰輔日本薬学会年会要旨集(CD-ROM) 136th- 2016

アミロイドβ前駆体タンパク質のO-結合型糖鎖に着目した細胞内イメージング
北爪しのぶ; 立田由里子; 木塚康彦; 栗本綾子; 田中克典; 斎藤貴志; 西道隆臣; 谷口直之 Dementia Japan 29- (3) 375 -375 2015/09

New mouse model of Alzheimer's disease
垣矢直雅; 斉藤貴志; 西道隆臣生体の科学 66- (4) 368 -374 2015/07

APPノックインマウスにおけるグルタチオン量減少メカニズムの解析
橋本翔子; 斉藤貴志; 永田健一; 西道隆臣 Dementia Japan 29- (3) 2015

次世代型アルツハイマー病モデルマウス脳におけるグルタチオン量減少メカニズムの解析
橋本翔子; 斉藤貴志; 西道隆臣日本生化学会大会(Web) 88th- 2015

アルツハイマー病における慢性炎症制御
斉藤貴志別冊BIO Clinica慢性炎症と疾患 4- 85 -90 2015 [Invited]

新規病態関連因子X過剰発現によるタウ病理への影響
佐藤亘; 高野二郎; 斉藤貴志; 西道隆臣 Dement Jpn 28- (4) 477 2014/10

認知症研究におけるCell Biology I リソソーム・オートファジーアルツハイマー病におけるAβ分泌とオートファジーに依存するプラーク形成(Alzheimer's disease Aβ secretion and plaque formation depend on autophagy)
パー・ニルソン; Hui Kelvin; 津吹聡; 赤木巧; 和泉伸一; 小守壽文; 田中元雅; 齊藤貴志; 岩田修永; 西道隆臣 Dementia Japan 28- (4) 424 -424 2014/10
認知症研究におけるCell Biology I リソソーム・オートファジーアルツハイマー病におけるAβ分泌とオートファジーに依存するプラーク形成(Alzheimer's disease Aβ secretion and plaque formation depend on autophagy)パー・ニルソン; Hui Kelvin; 津吹聡; 赤木巧; 和泉伸一; 小守壽文; 田中元雅...See More
認知症研究におけるCell Biology I リソソーム・オートファジーアルツハイマー病におけるAβ分泌とオートファジーに依存するプラーク形成(Alzheimer's disease Aβ secretion and plaque formation depend on autophagy)
パー・ニルソン; Hui Kelvin; 津吹聡; 赤木巧; 和泉伸一; 小守壽文; 田中元雅; 齊藤貴志; 岩田修永; 西道隆臣 Dementia Japan 28- (4) 424 -424 2014/10

認知症研究のトピックス新規アルツハイマー病モデルマウスの作製と応用
斉藤貴志; 松葉由紀夫; 三平尚美; 西道隆臣日本薬学会年会要旨集 134年会- (1) 136 -136 2014/03

認知症研究のトピックス BACE1の細胞内安定性をコントロールするバイセクト糖鎖
北爪しのぶ; 木塚康彦; 藤縄玲子; 斉藤貴志; 岩田修永; 西道隆臣; 中の三弥子; 山口芳樹; 橋本康弘; 初田裕幸; 村山繁雄; 萬谷博; 遠藤玉夫; 谷口直之日本薬学会年会要旨集 134年会- (1) 135 -135 2014/03

Aβとtauとをつなぐmissing piece分子の同定とその機能解析
一色隼人; 高野二郎; NILSSON Per; 佐藤亘; 橋本翔子; 村松慎一; 斉藤貴志; 西道隆臣 Dementia Japan 28- (4) 2014

次世代型ADモデルマウスを用いた因子YのAD病理における機能解析
橋本翔子; 斉藤貴志; 津吹聡; 西道隆臣 Dementia Japan 28- (4) 2014

Animal models of Alzheimer's disease
Saito akashi; C. Saido Takaomi Folia Pharmacologica Japonica 144- (5) 250 -252 2014 [Invited]

アルツハイマー病研究の今後の展望
齊藤貴志; 西道隆臣基礎老化研究 38- 19 -24 2014 [Invited]

アルツハイマー病に対する創薬
斉藤貴志臨床化学 43- 185 -190 2014 [Invited]

[Amyloidogenicity and pathogenicity of Abeta43 in Alzheimer's disease].
Saito T Seikagaku. The Journal of Japanese Biochemical Society 85- 543 -552 2013/07 [Refereed][Invited]

新規APPノックインマウスの作製と応用
斉藤貴志; 松葉由紀夫; 三平尚美; 岩田修永; 高野二郎; Nilsson Per; 西道隆臣 Dementia Japan 26- (4) 490 -490 2012/10

Novel type of "knock-in" mouse model for Alzheimer's disease
Takashi Saito; Takaomi Saido JOURNAL OF PHARMACOLOGICAL SCIENCES 115- 35P -35P 2011

脳血管内皮細胞はアミロイド前駆蛋白質770からアミロイドβを産生し、主にO-グリコシル体を分泌する(Brain endothelial cells produce amyloid p from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form)
立田由里子; 北爪しのぶ; 加藤雅樹; 山口芳樹; 本多たかし; 橋本康弘; 和田芳直; 斉藤貴志; 岩田修永; 西道隆臣; 谷口直之日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 83回・33回- 3T8 -2 2010/12
脳血管内皮細胞はアミロイド前駆蛋白質770からアミロイドβを産生し、主にO-グリコシル体を分泌する(Brain endothelial cells produce amyloid p from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form)立田由里子; 北爪しのぶ; 加藤雅樹;...See More
脳血管内皮細胞はアミロイド前駆蛋白質770からアミロイドβを産生し、主にO-グリコシル体を分泌する(Brain endothelial cells produce amyloid p from amyloid precursor protein 770 and preferentially secrete the O-glycosylated form)
立田由里子; 北爪しのぶ; 加藤雅樹; 山口芳樹; 本多たかし; 橋本康弘; 和田芳直; 斉藤貴志; 岩田修永; 西道隆臣; 谷口直之日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 83回・33回- 3T8 -2 2010/12

アルツハイマー病病態形成におけるAβ43の役割
斉藤貴志; 末元隆寛; 三平尚美; 松葉由紀夫; Nilsson Per; 高野二郎; 西村正樹; 岩田修永; 西道隆臣 Dementia Japan 24- (3) 391 -391 2010/09

Preventive and therapeutic strategy for Alzheimer's disease using Abeta-degrading enzyme neprilysin
Takashi Saito; Nobuhisa Iwata; Satoshi Tsubuki; Takaomi C. Saido Brain21 13- (1) 53 -58 2010

R278I-プレセニリン1変異が持つユニークな機能胎生致死とAβ43産生に伴うアミロイド病理の促進
斉藤貴志; 末元隆寛; 高野二郎; 三平尚美; 松葉由紀夫; 西村正樹; 岩田修永; 西道隆臣日本生化学会大会プログラム・講演要旨集 82回- 4P -559 2009/09

R278I-プレセニリン1家族性変異による新知見胎生致死とAβ43産生に伴うアミロイド病理の促進
斉藤貴志; 末元隆寛; 高野二郎; 三平尚美; 松葉由紀夫; 西村正樹; 岩田修永; 西道隆臣 Dementia Japan 23- (2) 197 -197 2009/08

FOXM1ではなくGLI1は不死化星状細胞の発癌形質転換を誘導する(GLI1 but not FOXM1 induces oncogenic transformation of immortalized astrocytes)
笹井研; 椨康一; 斉藤貴志; 松葉由紀夫; 西道隆臣; 田中伸哉日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 81回・31回- 1T19 -10 2008/11
FOXM1ではなくGLI1は不死化星状細胞の発癌形質転換を誘導する(GLI1 but not FOXM1 induces oncogenic transformation of immortalized astrocytes)笹井研; 椨康一; 斉藤貴志; 松葉由紀夫; 西道隆臣; 田中伸哉日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 81回・31回- 1T19 ...See More
FOXM1ではなくGLI1は不死化星状細胞の発癌形質転換を誘導する(GLI1 but not FOXM1 induces oncogenic transformation of immortalized astrocytes)
笹井研; 椨康一; 斉藤貴志; 松葉由紀夫; 西道隆臣; 田中伸哉日本生化学会大会・日本分子生物学会年会合同大会講演要旨集 81回・31回- 1T19 -10 2008/11

アミロイドβ分解を標的とするアルツハイマー病の予防・治療戦略
斉藤貴志; 岩田修永; 津吹聡; 西道隆臣実験医学 26- (16) 2566 -2571 2008/05 [Invited]

Accecelerated A beta plaque formation by presenilin-1 with R2781 mutation in a knock-in mouse model
Takahiro Suemoto; Takashi Saito; Jiro Takano; Naomi Yamazaki; Yukio Matsuba; Masaki Nishimura; Nobuhisa Iwata; Takaomi Saido NEUROSCIENCE RESEARCH 61- S122 -S122 2008
Accecelerated A beta plaque formation by presenilin-1 with R2781 mutation in a knock-in mouse modelTakahiro Suemoto; Takashi Saito; Jiro Takano; Naomi Yamazaki; Yukio Matsuba; Masaki Nishimura; Nobuhi...See More
Accecelerated A beta plaque formation by presenilin-1 with R2781 mutation in a knock-in mouse model
Takahiro Suemoto; Takashi Saito; Jiro Takano; Naomi Yamazaki; Yukio Matsuba; Masaki Nishimura; Nobuhisa Iwata; Takaomi Saido NEUROSCIENCE RESEARCH 61- S122 -S122 2008

Preventive and therapeutic strategy for Alzheimer's disease focusing Abeta degradation
Takashi Saito; Nobuhisa Iwata; Satoshi Tsubuki; Takaomi C. Saido Experimental Medicine 26- (16) 2566 -2571 2008
Preventive and therapeutic strategy for Alzheimer's disease focusing Abeta degradationTakashi Saito; Nobuhisa Iwata; Satoshi Tsubuki; Takaomi C. Saido Experimental Medicine 26- (16) 2566 -2571 2...See More
Preventive and therapeutic strategy for Alzheimer's disease focusing Abeta degradation
Takashi Saito; Nobuhisa Iwata; Satoshi Tsubuki; Takaomi C. Saido Experimental Medicine 26- (16) 2566 -2571 2008

A分解酵素ネプリライシンによるアルツハイマー病の予防・治療戦略
齊藤貴志; 岩田修永; 津吹聡; 西道隆臣脳21 13- 53 -58 2008 [Invited]

Modulator for neprilysin activity
岩田修永; 斉藤貴志; 西道隆臣 Japanese journal of clinical medicine 66- (0) 502 -506 2008/01

A secreted type of beta 1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase (vol 20, pg 2451, 2006)
Susumu Nakahara; Takashi Saito; Nami Kondo; Kenta Moriwaki; Katsuhisa Noda; Shinji Ihara; Motoko Takahashi; Yoshihito Ide; Jianguo Gu; Hidenori Inohara; Taiichi Katayama; Masaya Tohyama; Takeshi Kubo; Naoyuki Taniguchi; Eiji Miyoshi FASEB JOURNAL 21- (2) 630 -630 2007/02
A secreted type of beta 1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase (vol 20, pg 2451, 2006)Susumu Nakahara; Takashi Saito; Nami Kondo; ...See More
A secreted type of beta 1,6 N-acetylglucosaminyltransferase V (GnT-V), a novel angiogenesis inducer, is regulated by gamma-secretase (vol 20, pg 2451, 2006)
Susumu Nakahara; Takashi Saito; Nami Kondo; Kenta Moriwaki; Katsuhisa Noda; Shinji Ihara; Motoko Takahashi; Yoshihito Ide; Jianguo Gu; Hidenori Inohara; Taiichi Katayama; Masaya Tohyama; Takeshi Kubo; Naoyuki Taniguchi; Eiji Miyoshi FASEB JOURNAL 21- (2) 630 -630 2007/02

A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.
KINOSHITA A; SAITO T; MAKITA Y; YOSHIDA K; IKEGAWA S; NISHIMURA G; NAKAGOMI T; SAITO H; YOSHIURA K Nat Genet 26- (1) 19 -20 2007 [Refereed]
A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.KINOSHITA A; SAITO T; MAKITA Y; YOSHIDA K; IKEGAWA S; NISHIMURA G; NAKAGOMI T; SAITO H; YOSHIURA K ...See More
A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis.
KINOSHITA A; SAITO T; MAKITA Y; YOSHIDA K; IKEGAWA S; NISHIMURA G; NAKAGOMI T; SAITO H; YOSHIURA K Nat Genet 26- (1) 19 -20 2007 [Refereed]

ネプリライシンによるAβ分解とアルツハイマー病治療戦略
末元隆寛; 斉藤貴志; 岩田修永; 西道隆臣実験医学 25- (13) 1934 -1939 2007 [Invited]

Abeta degradation by neprilysin and therapeutic strategy of Alzheimer's disease
Takashi Saito; Nobuhisa Iwata; Satoshi Tsubuki; Takaomi C. Saido Experimental Medicine 25- (13) 1934 -1939 2007

Alzheimer病の診断Update：２．Alzheimer病におけるアミロイド分子病態
岩田修永; 斉藤貴志; 末元隆寛; 西道隆臣 Mebio 23- (6) 22 -23 2006 [Invited]

Diagnosis of Alzheimer's disease: molecular pathology of amyliods
Nobuhisa Iwata; Takashi Saito; Takahiro Suemoto; Takaomi C. Saido Mebio 23- (6) 22 -23 2006

Alzheimer病の最前線 3.発症前診断と予防・治療
岩田修永; 樋口真人; 斉藤貴志; 西道隆臣 Brain Nerve 57- (10) 855 -866 2005/10

発症前診断と予防・治療 (特集 Alzheimer病の最前線)
岩田修永; 樋口真人; 斉藤貴志脳と神経 57- (10) 855 -866 2005/10

Aβ分解機構--ソマトスタチンによるネプリライシン活性制御 (特集アルツハイマー病研究の最前線--基礎と臨床)
斎藤貴志; 岩田修永; 西道隆臣神経研究の進歩 49- (3) 339 -346 2005/06 [Invited]

Triple-transgenic アルツハイマー病モデルと治療への展望
斉藤貴志ファルマシア 41- (5) 442 -443 2005/05 [Invited]

Subretinal deposit formation in neprilysin gene-disrupted mice: An important role of amyloid beta in the pathogenesis of age-related macular degeneration
T Yoshida; K Ohno-Matsui; S Ichinose; N Iwata; T Saido; T Saito; T Hisatomi; A Kojima; Morita, I; M Mochizuki INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46- 2005
Subretinal deposit formation in neprilysin gene-disrupted mice: An important role of amyloid beta in the pathogenesis of age-related macular degenerationT Yoshida; K Ohno-Matsui; S Ichinose; N Iwata; ...See More
Subretinal deposit formation in neprilysin gene-disrupted mice: An important role of amyloid beta in the pathogenesis of age-related macular degeneration
T Yoshida; K Ohno-Matsui; S Ichinose; N Iwata; T Saido; T Saito; T Hisatomi; A Kojima; Morita, I; M Mochizuki INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 46- 2005

Therapeutic application of neprilysin-mediated amyloid-beta peptide-degrading system in Alzheimer's disease
N Iwata; T Saito; SM Huang; Y Takaki; M Higuchi; J Takano; S Matthias; TC Saido JOURNAL OF PHARMACOLOGICAL SCIENCES 97- 81P -81P 2005
Therapeutic application of neprilysin-mediated amyloid-beta peptide-degrading system in Alzheimer's diseaseN Iwata; T Saito; SM Huang; Y Takaki; M Higuchi; J Takano; S Matthias; TC Saido JOURNAL OF P...See More
Therapeutic application of neprilysin-mediated amyloid-beta peptide-degrading system in Alzheimer's disease
N Iwata; T Saito; SM Huang; Y Takaki; M Higuchi; J Takano; S Matthias; TC Saido JOURNAL OF PHARMACOLOGICAL SCIENCES 97- 81P -81P 2005

ソマトスタチンによるアルツハイマー病の治療
斉藤貴志; 岩田修永; 西道隆臣 Dementia Japan 19- 86 -90 2005 [Invited]

Aβ分解促進によるアルツハイマー病治療へのアプローチ－ソマトスタチンによるネプリライシン活性制御機構
斉藤貴志; 岩田修永; 西道隆臣 THE LUNG perspective 13- 95 -100 2005 [Invited]

A mechanism of Abeta degradation -regulation of neprilysin activity by somatostatin
Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido 49- (3) 339 -346 2005

Therapy for Alzheimer's disease by utilizing somatostatin
Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido Dementia Japan 19- (1) 86 -90 2005

An approach of Alzheimer's disease therapy using activation of Abeta degradation-a regulatory mechanism of neprilysin activity by somatostatin
Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido THE LUNG perspective 13- 95 -100 2005
An approach of Alzheimer's disease therapy using activation of Abeta degradation-a regulatory mechanism of neprilysin activity by somatostatinTakashi Saito; Nobuhisa Iwata; Takaomi C. Saido THE LUNG ...See More
An approach of Alzheimer's disease therapy using activation of Abeta degradation-a regulatory mechanism of neprilysin activity by somatostatin
Takashi Saito; Nobuhisa Iwata; Takaomi C. Saido THE LUNG perspective 13- 95 -100 2005

Neuropeptides regulate brain amyloid beta levels through a modulation of neprilysin activity
T Saito; N Iwata; Y Takaki; M Higuchi; E Hosoki; M Sekiguchi; Y Matsuba; TC Saido NEUROBIOLOGY OF AGING 25- S525 -S525 2004/07
Neuropeptides regulate brain amyloid beta levels through a modulation of neprilysin activityT Saito; N Iwata; Y Takaki; M Higuchi; E Hosoki; M Sekiguchi; Y Matsuba; TC Saido NEUROBIOLOGY OF AGING 25...See More
Neuropeptides regulate brain amyloid beta levels through a modulation of neprilysin activity
T Saito; N Iwata; Y Takaki; M Higuchi; E Hosoki; M Sekiguchi; Y Matsuba; TC Saido NEUROBIOLOGY OF AGING 25- S525 -S525 2004/07

Alzheimer病の創薬ターゲット分子 (第1土曜特集ユニークな創薬ターゲット分子--夢の薬に向かって) -- (難治性疾患治療のための創薬ターゲット分子)
斉藤貴志; 西道隆臣医学のあゆみ 207- (1) 51 -54 2003/10 [Invited]

可溶型GnT‐Vの役割とその分泌機構
中原晋; 三善英知; 斉藤貴志; 高橋素子; 野田勝久; 伊原伸治; 本家孝一; 猪原秀典; 久保武日本癌学会総会記事 62nd- 105 2003/08

アミロイドβ蛋白の分解機構 (特集第37回脳のシンポジウム) -- (アルツハイマー病研究の進歩--アミロイドβ蛋白を中心に)
斉藤貴志; 西道隆臣神経研究の進歩 46- (6) 807 -812 2002/12 [Invited]

分泌型beta1,6‐N‐アセチルグルコサミン転移酵素‐V(GnT‐V)による血管新生の誘導
斉藤貴志; 三善英知; 笹井研; 中野法彦; 江口裕伸; 本家孝一; 谷口直之生化学 74- (8) 837 -837 2002/08

A secreted type of _1, 6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation
M. E.; S. T.; S. K.; N. N.; E. H.; H. K.; T. N. Japan Journal of Molecular Tumor Marker Research 18- 20 -21 2002
A secreted type of _1, 6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylationM. E.; S. T.; S. K.; N. N.; E. H.; H. K.; T. N. Japan Journal of Molecu...See More
A secreted type of _1, 6-N-acetylglucosaminyltransferase V (GnT-V) induces tumor angiogenesis without mediation of glycosylation
M. E.; S. T.; S. K.; N. N.; E. H.; H. K.; T. N. Japan Journal of Molecular Tumor Marker Research 18- 20 -21 2002

A role of the secreted type of beta 1,6-N-acetylglucosaminyltransferase V (GnT-V) on tumor growth and metastasis
T Saito; E Miyoshi; N Taniguchi JAPANESE JOURNAL OF PHARMACOLOGY 88- 38P -38P 2002

TGF-β1 latency-associated peptideの部位特異的変異によるCamurati-Engelmann病発症機構の解析
斉藤貴志; 木下晃; 本家孝一; 新川詔夫; 谷口直之生化学 73- (8) 1028 -1028 2001/08

Domain-specific mutations in the human transforming growth factor beta 1 gene (TGFB1) result in Camurati-Engelmann disease.
A Kinoshita; T Saito; M Ghadami; H Tomita; Y Makita; K Yamada; S Ikegawa; G Nishimura; Y Fukushima; JC Murray; N Taniguchi; N Niikawa; K Yoshiura AMERICAN JOURNAL OF HUMAN GENETICS 67- (4) 370 -370 2000/10
Domain-specific mutations in the human transforming growth factor beta 1 gene (TGFB1) result in Camurati-Engelmann disease.A Kinoshita; T Saito; M Ghadami; H Tomita; Y Makita; K Yamada; S Ikegawa; G N...See More
Domain-specific mutations in the human transforming growth factor beta 1 gene (TGFB1) result in Camurati-Engelmann disease.
A Kinoshita; T Saito; M Ghadami; H Tomita; Y Makita; K Yamada; S Ikegawa; G Nishimura; Y Fukushima; JC Murray; N Taniguchi; N Niikawa; K Yoshiura AMERICAN JOURNAL OF HUMAN GENETICS 67- (4) 370 -370 2000/10

N-アセチルグルコサミン転移酵素V(GnT-V)による癌転移機構の解明
伊原伸治; 三善英知; 高正憲; 斉藤貴志; 谷口直之日本癌学会総会記事 59回- 332 -332 2000/09

N‐アセチルグルコサミン転移酵素V(GnT‐V)による癌転移機構の解明
伊原伸治; 三善英知; KO J‐H; 斉藤貴志; 谷口直之 Jpn J Cancer Res 91- (Supplement (Sept)) 332 2000/09

糖鎖リモデリングTIMP‐1によるマトリックスメタロプロテアーゼ(MMPs)阻害活性についての解析 TIMP‐1に付加した糖鎖の役割
斉藤貴志; 三善英知; 本家孝一; 谷口直之生化学 72- (8) 715 -715 2000/08

N‐アセチルグルコサミン転移酵素V(GnT‐V)が分泌誘導するプロテアーゼの同定
伊原伸治; 三善英知; 高正憲; 斉藤貴志; 本家孝一; 谷口直之生化学 72- (8) 1056 2000/08

Awards & Honors

2023/11 Clarivate Highly Cited Researcher 2023

受賞者: Takashi Saito

2022/11 Clarivate Highly Cited Researcher 2022

受賞者: Takashi Saito

2015/10 日本認知症学会 Prize of Japan Society for Dementia Research
アルツハイマー病研究に資するモデルマウスの開発と応用
受賞者: 斉藤貴志

2013/04 文部科学省 The Commendation for Science and Technology by the Minister of MEXT (The Young Scientist’s Prize)
アルツハイマー病の病態発症・促進機構に関する研究
受賞者: 斉藤貴志

2012/10 日本生化学会 Young Investigator Award of the Japanese Biochemical Society
アミロイドβ43によるアルツハイマー病の病態発症・促進機構に関する研究
受賞者: 斉藤貴志

Research Grants & Projects

タウオパチーにおけるグリア－末梢免疫連関および脳プロテオスタシス変容の理解と制御
AMED：脳神経科学統合プログラム
Date (from‐to) : 2024/09 -2030/03
Author : 齊藤貴志; 富田泰輔; 池内健; 他田真理

Development of novel therapeutic strategies of chronic inflammatory diseases by using inflammatory memory cell visualizing mouse
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2023/04 -2028/03
Author : 古賀友紹; 甲斐広文; 斉藤貴志
Development of novel therapeutic strategies of chronic inflammatory diseases by using inflammatory memory cell visualizing mouseJapan Society for the Promotion of Science：Grants-in-Aid for Scientific ...See More
Development of novel therapeutic strategies of chronic inflammatory diseases by using inflammatory memory cell visualizing mouse
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2023/04 -2028/03
Author : 古賀友紹; 甲斐広文; 斉藤貴志

アルツハイマー病病態形成における非炎症性グリア応答の理解と制御
日本学術振興会：科学研究費助成事業基盤研究(B) 基盤研究(B)
Date (from‐to) : 2024/04 -2027/03
Author : 齊藤貴志

アルツハイマー病病態のマウス脳内での完全モデル化への挑戦
公益財団法人堀科学芸術振興財団：研究助成第２部
Date (from‐to) : 2024/04 -2026/03
Author : 齊藤貴志

脳卒中・認知症の完全回復に向けた持続可能な神経回路の再構築を実現する治療開発
AMED-CREST：革新的先端研究開発支援事業（適応・修復研究開発領域）
Date (from‐to) : 2020/10 -2026/03
Author : 七田崇; 斉藤貴志

臓器連関の包括的理解に基づく認知症関連疾患の克服に向けて
科学技術振興機構：ムーンショット
Date (from‐to) : 2021/04 -2025/11
Author : 高橋良輔

Elucidation of chemokine cross-talk underlying pathogenesis of Alzheimer's disease
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2020/04 -2024/03
Author : 斉藤貴志

アルツハイマー病（AD）などの神経変性疾患の克服は、社会的要請の大きな世界的課題である。そのため、発症分子機構を明らかにして、創薬標的を早急に提示する必要がある。これまでの神経細胞中心に着目した研究の限界が世界規模で懸念されており、脳内環境として神経細胞以外のグリア細胞と神経細胞の相互作用の解析が着目されはじめているが、その複雑性から解析は遅れている。２０２１年度は、前年度に見いだしたアミロイド病理およびタウ病理をそれぞれの病理に特異的に連動するサイトカイン/ケモカインスクリーニングについて、それぞれのノックアウトマウスとの産仔の解析を行った。まず、アミロイド病理に連動するケモカインA（ChemoA）の役割についての解析では、APP knockin x ChemoA-KOマウスでは、その若齢においてもアミロイドβ量の増加が認められた。分子メカニズムは明らかになっていないが、単一のケモカイン欠損によって病理を変動させる興味深い結果が得られた。次年度以降、さらに高齢のマウスの解析を進め、その分子メカニズムの解明に移行していく。次に、タウ病理に連動するケモカインT（ChemoT）については、交配でトラブルが生じたが、年度終わりに無事に産仔が得られはじめた。新年度から、ChemoA同様に若齢解析から開始する。本研究計画では、申請者らが創出したADモデルマウスを用いて、ケモカインレベルの制御がどのように病理形成に影響するのかを明らかにし、これまでにない新たな創薬標的を提示できる可能性が高く、今後の解析が期待される。
Elucidation of chemokine cross-talk underlying pathogenesis of Alzheimer's diseaseJapan Society for the Promotion of Science：Grants-in-Aid for Scientific ResearchDate (from‐to) : 2020/04 -2024/03 Aut...See More
Elucidation of chemokine cross-talk underlying pathogenesis of Alzheimer's disease
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2020/04 -2024/03
Author : 斉藤貴志

アルツハイマー病（AD）などの神経変性疾患の克服は、社会的要請の大きな世界的課題である。そのため、発症分子機構を明らかにして、創薬標的を早急に提示する必要がある。これまでの神経細胞中心に着目した研究の限界が世界規模で懸念されており、脳内環境として神経細胞以外のグリア細胞と神経細胞の相互作用の解析が着目されはじめているが、その複雑性から解析は遅れている。２０２１年度は、前年度に見いだしたアミロイド病理およびタウ病理をそれぞれの病理に特異的に連動するサイトカイン/ケモカインスクリーニングについて、それぞれのノックアウトマウスとの産仔の解析を行った。まず、アミロイド病理に連動するケモカインA（ChemoA）の役割についての解析では、APP knockin x ChemoA-KOマウスでは、その若齢においてもアミロイドβ量の増加が認められた。分子メカニズムは明らかになっていないが、単一のケモカイン欠損によって病理を変動させる興味深い結果が得られた。次年度以降、さらに高齢のマウスの解析を進め、その分子メカニズムの解明に移行していく。次に、タウ病理に連動するケモカインT（ChemoT）については、交配でトラブルが生じたが、年度終わりに無事に産仔が得られはじめた。新年度から、ChemoA同様に若齢解析から開始する。本研究計画では、申請者らが創出したADモデルマウスを用いて、ケモカインレベルの制御がどのように病理形成に影響するのかを明らかにし、これまでにない新たな創薬標的を提示できる可能性が高く、今後の解析が期待される。

アルツハイマー病病態形成におけるアミロイド病理特異的ケモカインの制御と創薬展開
公益財団法人三菱財団：三菱財団自然科学助成
Date (from‐to) : 2022/10 -2023/09
Author : 齊藤貴志

Development of innovative drugs having multistep action for treatment of central cerebral amyloidosis
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Date (from‐to) : 2020/04 -2023/03
Author : 有馬英俊; 北岸宏亮; 川上茂; 山吉麻子; 斉藤貴志

アルツハイマー病に対する薬剤の臨床試験は数多くなされているが、その成功例はほとんどなく、有効な治療薬の開発が強く望まれている。我々はアルツハイマー病に対する複数の危険因子に対して個々に作用する薬剤ではなく、5つの危険因子（脳におけるAPOε4遺伝子発現、コレステロール蓄積、脳炎症反応、アミロイド線維形成・蓄積、神経原繊維変化）に対して多段階かつ同時に抑制する薬剤の開発を期待して、我々が開発した新規化合物であるシクロデキストリン/ポリアミドアミンデンドリマー結合体（CDE)に、さらに静脈内投与後の有効性を可能にする血液脳関門（BBB）透過リガンドを結合したBPB-CDEの構築に関する研究を行っている。また、Apoε4遺伝子発現を特異的に抑制できるsiRNA（Apo-siRNA）とBPB-CDEとの複合体を調製し、それらの化学的・物理的性質、細胞膜透過性、Aβ凝集・繊維形成抑制・溶解効果などの検討を予定し、2021年度は次のような検討を行った。β-シクロデキストリンとPAMAMデンドリマーとの結合体（CDE）にBBB透過リガンドを結合体したBPP-CDEの合成・精製・構造解析を行った。Aβペプチド（1-40）及びAβペプチド（1-42）の凝集体形成に及ぼすPAMAMデンドリマー及びBPP-CDEの影響について検討を行った。また、Aβペプチド（1-40）とPAMAMデンドリマー及びBPP-CDE との相互作用をNMRを用いて検討した。PAMAMデンドリマー及びBPP-CDEとsiRNA複合体を調製し、その粒子径・PDI・ゼータ電位等の物性について測定する準備を行った。論文公表１件、学会発表２件を行った。
Development of innovative drugs having multistep action for treatment of central cerebral amyloidosisJapan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for S...See More
Development of innovative drugs having multistep action for treatment of central cerebral amyloidosis
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (B)
Date (from‐to) : 2020/04 -2023/03
Author : 有馬英俊; 北岸宏亮; 川上茂; 山吉麻子; 斉藤貴志

アルツハイマー病に対する薬剤の臨床試験は数多くなされているが、その成功例はほとんどなく、有効な治療薬の開発が強く望まれている。我々はアルツハイマー病に対する複数の危険因子に対して個々に作用する薬剤ではなく、5つの危険因子（脳におけるAPOε4遺伝子発現、コレステロール蓄積、脳炎症反応、アミロイド線維形成・蓄積、神経原繊維変化）に対して多段階かつ同時に抑制する薬剤の開発を期待して、我々が開発した新規化合物であるシクロデキストリン/ポリアミドアミンデンドリマー結合体（CDE)に、さらに静脈内投与後の有効性を可能にする血液脳関門（BBB）透過リガンドを結合したBPB-CDEの構築に関する研究を行っている。また、Apoε4遺伝子発現を特異的に抑制できるsiRNA（Apo-siRNA）とBPB-CDEとの複合体を調製し、それらの化学的・物理的性質、細胞膜透過性、Aβ凝集・繊維形成抑制・溶解効果などの検討を予定し、2021年度は次のような検討を行った。β-シクロデキストリンとPAMAMデンドリマーとの結合体（CDE）にBBB透過リガンドを結合体したBPP-CDEの合成・精製・構造解析を行った。Aβペプチド（1-40）及びAβペプチド（1-42）の凝集体形成に及ぼすPAMAMデンドリマー及びBPP-CDEの影響について検討を行った。また、Aβペプチド（1-40）とPAMAMデンドリマー及びBPP-CDE との相互作用をNMRを用いて検討した。PAMAMデンドリマー及びBPP-CDEとsiRNA複合体を調製し、その粒子径・PDI・ゼータ電位等の物性について測定する準備を行った。論文公表１件、学会発表２件を行った。

神経炎症を標的とする神経変性疾患・認知症の分子病態解明と治療法開発
公益財団法人堀科学芸術振興財団研究費助成
Date (from‐to) : 2020/04 -2023/03
Author : 山中宏二; 斉藤貴志

アルツハイマー病早期発見に資する新規血液診断マーカ―の確立と診断法開発に関する研究
AMED：認知症開発研究事業
Date (from‐to) : 2020/04 -2023/03
Author : 道川誠、松川則之、斉藤貴志

アルツハイマー病病態におけるタウ病理の本質解明
公益財団法人豊秋奨学会研究助成
Date (from‐to) : 2020/10 -2022/09
Author : 斉藤貴志

Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification system
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2019/06 -2022/03
Author : TACHIKAWA Masanori

This study aims to validate our hypothesis that the blood-arachnoid barrier possesses the dynamic clearance system for neurotoxic substances in the cerebrospinal fluid and functions as a central nervus system detoxification system. The present study has proposed that α-synuclein, a pathogenic protein, which is known to be and accumulated in the brain of the Parkinson’s disease, would undergo the LDL receptor-related protein-mediated efflux transport from the cerebrospinal fluid. The study has also established the comprehensive proteomics and the LC-MS/MS-based targeted absolute quantification system for extracellular vesicles, pathogenic proteins, peptides, and metabolites to clarify various efflux transport system at the blood-arachnoid barrier.
Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification systemJapan Society for the Promotion of Science：Grants-in-Aid f...See More
Challenges to the hypothesis that the blood-arachnoid barrier efflux transport systems function as central nervus system detoxification system
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2019/06 -2022/03
Author : TACHIKAWA Masanori

This study aims to validate our hypothesis that the blood-arachnoid barrier possesses the dynamic clearance system for neurotoxic substances in the cerebrospinal fluid and functions as a central nervus system detoxification system. The present study has proposed that α-synuclein, a pathogenic protein, which is known to be and accumulated in the brain of the Parkinson’s disease, would undergo the LDL receptor-related protein-mediated efflux transport from the cerebrospinal fluid. The study has also established the comprehensive proteomics and the LC-MS/MS-based targeted absolute quantification system for extracellular vesicles, pathogenic proteins, peptides, and metabolites to clarify various efflux transport system at the blood-arachnoid barrier.

Establishment of a motivated behavior assessment system for long-term administration of Kampo medicine and application of Kampo medicine in treating apathy
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2016/04 -2019/03
Author : Hamaguchi Takuya; TANAKA Kenji; KIMURA Iku; SAIDO Takaomi; SAITO Takashi

We established a motivated behavior assessment system to study the effect of Kampo medicine in mice. Using this system, we evaluated the motivated behavior of AppNL-G-F/NL-G-F mice, an Alzheimer's disease model, until they were 39 weeks old. Motivated behavior in some mice decreased. Histological analysis of the AppNL-G-F/NL-G-F mice at 39 weeks old showed that an increased number of cored amyloid plaques in the striatum coincided with decreased motivated behavior. Western blotting analysis of the AppNL-G-F/NL-G-F mice at 9 months old showed decreased dopamine transporter levels in the subcortical tissue, including the striatum. These results suggest a pathway through which cored amyloid plaques damage the dopamine transporter and result in impaired motivated behavior.
Establishment of a motivated behavior assessment system for long-term administration of Kampo medicine and application of Kampo medicine in treating apathyJapan Society for the Promotion of Science：Gr...See More
Establishment of a motivated behavior assessment system for long-term administration of Kampo medicine and application of Kampo medicine in treating apathy
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2016/04 -2019/03
Author : Hamaguchi Takuya; TANAKA Kenji; KIMURA Iku; SAIDO Takaomi; SAITO Takashi

We established a motivated behavior assessment system to study the effect of Kampo medicine in mice. Using this system, we evaluated the motivated behavior of AppNL-G-F/NL-G-F mice, an Alzheimer's disease model, until they were 39 weeks old. Motivated behavior in some mice decreased. Histological analysis of the AppNL-G-F/NL-G-F mice at 39 weeks old showed that an increased number of cored amyloid plaques in the striatum coincided with decreased motivated behavior. Western blotting analysis of the AppNL-G-F/NL-G-F mice at 9 months old showed decreased dopamine transporter levels in the subcortical tissue, including the striatum. These results suggest a pathway through which cored amyloid plaques damage the dopamine transporter and result in impaired motivated behavior.

次世代型アルツハイマー病モデルマウスを用いたω3脂肪酸による認知症の周辺症状緩和への展開
糧食研究会研究助成金
Date (from‐to) : 2018/04 -2019/03
Author : 斉藤貴志

アルツハイマー病における神経細胞死機構の解明とそれを標的とする治療法の確立
内藤記念科学振興財団研究助成金
Date (from‐to) : 2018/04 -2019/03
Author : 斉藤貴志

孤発性アルツハイマー病アミロイド蓄積の原因に即した治療薬と診断用バイオマーカーの開発
AMED：脳科学研究戦略推進プログラム
Date (from‐to) : 2016/04 -2019/03
Author : 岩田修永、岩田淳、斉藤貴志

Elucidation for role of intracellular/extracellulra quality control system in pathogenesis of Alzheimer's disease
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2014 -2016
Author : Saito Takashi; MATSUBA Yukio; Mihira Naomi

To elucidate molecular mechanisms for pathogenesis of Alzheimer’s disease, we investigated a role of intracellular and extracellular quality control system in next generation AD mouse models, Amyloid precursor protein (APP) knockin (KI) mice, which we developed. The results taken by using existed AD mouse models which were APP overexpressing model in almost case could not be reproduced by using APP KI mice due to artifacts of APP overexpressing mouse models. Thereby, APP KI mouse models would be new world standard model for AD research community and be useful for elucidation of molecular mechanisms under pathogenesis of AD.
Elucidation for role of intracellular/extracellulra quality control system in pathogenesis of Alzheimer's diseaseJapan Society for the Promotion of Science：Grants-in-Aid for Scientific ResearchDate (f...See More
Elucidation for role of intracellular/extracellulra quality control system in pathogenesis of Alzheimer's disease
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2014 -2016
Author : Saito Takashi; MATSUBA Yukio; Mihira Naomi

To elucidate molecular mechanisms for pathogenesis of Alzheimer’s disease, we investigated a role of intracellular and extracellular quality control system in next generation AD mouse models, Amyloid precursor protein (APP) knockin (KI) mice, which we developed. The results taken by using existed AD mouse models which were APP overexpressing model in almost case could not be reproduced by using APP KI mice due to artifacts of APP overexpressing mouse models. Thereby, APP KI mouse models would be new world standard model for AD research community and be useful for elucidation of molecular mechanisms under pathogenesis of AD.

アルツハイマー病発症機構の解明
細胞科学研究財団助成金
Date (from‐to) : 2013/04 -2015/03
Author : 斉藤貴志

Elucidation of the role of chronic inflammation underlying pathogenesis of Alzheimer's disease
JST：PRESTO
Date (from‐to) : 2012/10 -2015
Author : Takashi Saito

脳という特殊環境下における炎症反応の慢性化は、加齢に伴い高次機能へ様々な影響を及ぼしていると考えられます。本研究では、新規アルツハイマー病モデルマウスと炎症関連遺伝子改変マウスとの交配マウスの解析により、アルツハイマー病の病態悪性化における炎症反応の役割について、分子レベルでの解明に取り組みます。最終的には、アルツハイマー病の予防・治療・発症遅延に貢献する創薬標的を見出すことを目指します。
Elucidation of the role of chronic inflammation underlying pathogenesis of Alzheimer's diseaseJST：PRESTODate (from‐to) : 2012/10 -2015 Author : Takashi Saito 脳という特殊環境下における炎症反応の慢性化は、加齢に伴い高次機能へ様々な影響を及ぼ...See More
Elucidation of the role of chronic inflammation underlying pathogenesis of Alzheimer's disease
JST：PRESTO
Date (from‐to) : 2012/10 -2015
Author : Takashi Saito

脳という特殊環境下における炎症反応の慢性化は、加齢に伴い高次機能へ様々な影響を及ぼしていると考えられます。本研究では、新規アルツハイマー病モデルマウスと炎症関連遺伝子改変マウスとの交配マウスの解析により、アルツハイマー病の病態悪性化における炎症反応の役割について、分子レベルでの解明に取り組みます。最終的には、アルツハイマー病の予防・治療・発症遅延に貢献する創薬標的を見出すことを目指します。

Establishment and application of novel type of Alzheimer's disease model mouse
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2011 -2012
Author : SAITO Takashi

Experimental studies of Alzheimer's disease (AD) have largely depended on transgenic (Tg) mice overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial phenotypes because not only amyloid beta peptide (Abeta) but also other APP fragments are overproduced. To overcome these drawbacks, we generated knockin mice that harbor Swedish and Iberian mutations in the APP gene, and demonstrated that these animals start accumulating Abetaat 6 months and show memory impairment at 18 months without APP overexpression. We also generated mice containing an additional Arctic mutation; these started depositing Abeta at 2 months and showed memory impairment at 6 months with aggressive neuroinflammation. We provide the research community with these lines in order to distinguish facts from artifacts in APP-Tg mice and to identify pathological mechanisms upstream and downstream of Abeta deposition.
Establishment and application of novel type of Alzheimer's disease model mouseJapan Society for the Promotion of Science：Grants-in-Aid for Scientific ResearchDate (from‐to) : 2011 -2012 Author : SAIT...See More
Establishment and application of novel type of Alzheimer's disease model mouse
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2011 -2012
Author : SAITO Takashi

Experimental studies of Alzheimer's disease (AD) have largely depended on transgenic (Tg) mice overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial phenotypes because not only amyloid beta peptide (Abeta) but also other APP fragments are overproduced. To overcome these drawbacks, we generated knockin mice that harbor Swedish and Iberian mutations in the APP gene, and demonstrated that these animals start accumulating Abetaat 6 months and show memory impairment at 18 months without APP overexpression. We also generated mice containing an additional Arctic mutation; these started depositing Abeta at 2 months and showed memory impairment at 6 months with aggressive neuroinflammation. We provide the research community with these lines in order to distinguish facts from artifacts in APP-Tg mice and to identify pathological mechanisms upstream and downstream of Abeta deposition.

Establishment of the diagnostics of Alzheimer' s disease using A・43
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2011 -2012
Author : SAITO Takashi

Establishment of an early diagnosis for Alzheimer’s disease (AD) is one of the important missions in an aging society. Recently, we found that Ass43 is generated under an age-dependent manner, thereby it might be a good candidate as a marker for an early diagnosis of AD. Herein, we established a high-sensitive and quantitative method to detect Ass43 specifically in the sample from mice and human materials. Finally, we concluded that Ass43 has a potent pathogenicity, and would be an useful candidate for an early diagnosis for AD.
Establishment of the diagnostics of Alzheimer' s disease using A・43Japan Society for the Promotion of Science：Grants-in-Aid for Scientific ResearchDate (from‐to) : 2011 -2012 Author : SAITO Takashi E...See More
Establishment of the diagnostics of Alzheimer' s disease using A・43
Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
Date (from‐to) : 2011 -2012
Author : SAITO Takashi

Establishment of an early diagnosis for Alzheimer’s disease (AD) is one of the important missions in an aging society. Recently, we found that Ass43 is generated under an age-dependent manner, thereby it might be a good candidate as a marker for an early diagnosis of AD. Herein, we established a high-sensitive and quantitative method to detect Ass43 specifically in the sample from mice and human materials. Finally, we concluded that Ass43 has a potent pathogenicity, and would be an useful candidate for an early diagnosis for AD.

ネプリライシンを中軸とするアルツハイマー病予防・治療のための創薬標的の探索
文部科学省：科学研究費補助金(挑戦的萌芽研究)
Date (from‐to) : 2009 -2010
Author : 斉藤貴志

アルツハイマー病(AD)発症の主因の一つとされるアミロイドβペプチド(Aβ)。このAβを脳内で分解する主要プロテアーゼ「ネプリライシン(NEP)」の活性制御機構を明らかにすることは、脳内Aβレベルを制御する上で極めて重要である。これまでに神経栄養因子NGF,BDNF,NT-3,NT-4の作用により、NEPの活性が著しく低下する事が確認された。この機構には、MAPキナーゼ(MAPK)経路が関与していた。さらに、NEPの細胞質領域(N末端)にある5カ所のセリン/スレオニン残基のうち、ある特定のセリン/スレオニン残基のリン酸化が、NEPの活性制御に関与していることが明らかとなった。しかも、リン酸化型NEPは、細胞膜上から細胞内へと局在を変化させることも明らかとなった。これらの結果から、NEPは、N末端のリン酸化により、細胞表面からの局在が変化することで、細胞外に分泌されたAβに対する分解能が低下していることが明らかとなった。一方、NEPのN末端の脱リン酸化の効果を検討するために、フォスファターゼ阻害剤を用いた解析も行った。その結果、PP1Aとカルシニューリンの各阻害剤によりNEP活性の低下が認められた。脱リン酸化をミミックした(リン酸化を受けない)NEPコンストラクトに恒常的活性化能があることも見出された。総じて、NEPは、細胞質領域(N末端)のリン酸化状態によって、細胞表面での活...
ネプリライシンを中軸とするアルツハイマー病予防・治療のための創薬標的の探索文部科学省：科学研究費補助金(挑戦的萌芽研究)Date (from‐to) : 2009 -2010 Author : 斉藤貴志アルツハイマー病(AD)発症の主因の一つとされるアミロイドβペプチド(Aβ)。このAβを脳内で分解する主要プロテアーゼ「ネプリライシン(NEP)」の活性制御機構を明らかにすることは、脳内Aβレベ...See More
ネプリライシンを中軸とするアルツハイマー病予防・治療のための創薬標的の探索
文部科学省：科学研究費補助金(挑戦的萌芽研究)
Date (from‐to) : 2009 -2010
Author : 斉藤貴志

アルツハイマー病(AD)発症の主因の一つとされるアミロイドβペプチド(Aβ)。このAβを脳内で分解する主要プロテアーゼ「ネプリライシン(NEP)」の活性制御機構を明らかにすることは、脳内Aβレベルを制御する上で極めて重要である。これまでに神経栄養因子NGF,BDNF,NT-3,NT-4の作用により、NEPの活性が著しく低下する事が確認された。この機構には、MAPキナーゼ(MAPK)経路が関与していた。さらに、NEPの細胞質領域(N末端)にある5カ所のセリン/スレオニン残基のうち、ある特定のセリン/スレオニン残基のリン酸化が、NEPの活性制御に関与していることが明らかとなった。しかも、リン酸化型NEPは、細胞膜上から細胞内へと局在を変化させることも明らかとなった。これらの結果から、NEPは、N末端のリン酸化により、細胞表面からの局在が変化することで、細胞外に分泌されたAβに対する分解能が低下していることが明らかとなった。一方、NEPのN末端の脱リン酸化の効果を検討するために、フォスファターゼ阻害剤を用いた解析も行った。その結果、PP1Aとカルシニューリンの各阻害剤によりNEP活性の低下が認められた。脱リン酸化をミミックした(リン酸化を受けない)NEPコンストラクトに恒常的活性化能があることも見出された。総じて、NEPは、細胞質領域(N末端)のリン酸化状態によって、細胞表面での活...

Generation and application of the novel mouse model for Alzheimer's disease
Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(若手研究(A))
Date (from‐to) : 2007 -2009
Author : Takashi SAITO

We generated two lines of the novel mouse model for Alzheimer's disease (AD), amyloid precursor protein (APP) knock-in (KI) mouse and presenilin1(PS1)-KI mouse. Each KI mice has the familial AD mutations. The mice showed relevance phenotypes rather than previous AD model mouse. These mice would be a useful tool for the prevention, the treatment and the drug discovery of AD.
Generation and application of the novel mouse model for Alzheimer's diseaseMinistry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(若手研究(A))Date (from‐to) ...See More
Generation and application of the novel mouse model for Alzheimer's disease
Ministry of Education, Culture, Sports, Science and Technology：Grants-in-Aid for Scientific Research(若手研究(A))
Date (from‐to) : 2007 -2009
Author : Takashi SAITO

We generated two lines of the novel mouse model for Alzheimer's disease (AD), amyloid precursor protein (APP) knock-in (KI) mouse and presenilin1(PS1)-KI mouse. Each KI mice has the familial AD mutations. The mice showed relevance phenotypes rather than previous AD model mouse. These mice would be a useful tool for the prevention, the treatment and the drug discovery of AD.

ソマトスタチンによるアミロイドβ分解酵素ネプリライシンの活性制御機構の解明
文部科学省：科学研究費補助金(若手研究(B))
Date (from‐to) : 2005 -2006
Author : 斉藤貴志

アルツハイマー病(AD)の予防・治療法の確立は、本邦における重要な課題の一つである。ADの発症は、脳内のアミロイドβペプチド(Aβ)の蓄積に起因すると考えられており、脳内においていかにAβを制御できるかが重要な手がかりとなる。ネプリライシンは、Aβ分解の主要プロテアーゼであり、この活性・発現制御機構の解明が、脳内Aβ量の減少によるADの予防・治療法の確立のために大きく貢献すると考えられる。昨年度の成果において、我々は、神経ペプチドの一つソマトスタチン(SST)が、脳内ネプリライシンの活性・発現を制御している因子として同定した。SSTは、ソマトスタチン受容体(SSTR)を介して様々な生理作用を発揮することが知られており、これまでに5種類が同定されている。もし、どのSSTRがネプリライシンの活性・発現を制御しているのかが明らかになれば、その特異的なアゴニストにより、ネプリライシンの活性を高め、効率的にAβ量を減少させることができ、かっ副作用も小さいと予想される。本申請課題では、SSTR3とSSTR4欠損マウスを用いて、これらの脳内におけるネプリライシンの活性・発現及びAβ量の定量を行った。その結果SSTR4欠損マウスでは、野生型と比較してネプリライシンの活性・発現、Aβ代謝に関する他の因子の活性等に差が認められないものの、脳内でのAβ42/Aβ40比が有意に増加していることが明ら...
ソマトスタチンによるアミロイドβ分解酵素ネプリライシンの活性制御機構の解明文部科学省：科学研究費補助金(若手研究(B))Date (from‐to) : 2005 -2006 Author : 斉藤貴志アルツハイマー病(AD)の予防・治療法の確立は、本邦における重要な課題の一つである。ADの発症は、脳内のアミロイドβペプチド(Aβ)の蓄積に起因すると考えられており、脳内においていかにAβを制御...See More
ソマトスタチンによるアミロイドβ分解酵素ネプリライシンの活性制御機構の解明
文部科学省：科学研究費補助金(若手研究(B))
Date (from‐to) : 2005 -2006
Author : 斉藤貴志

アルツハイマー病(AD)の予防・治療法の確立は、本邦における重要な課題の一つである。ADの発症は、脳内のアミロイドβペプチド(Aβ)の蓄積に起因すると考えられており、脳内においていかにAβを制御できるかが重要な手がかりとなる。ネプリライシンは、Aβ分解の主要プロテアーゼであり、この活性・発現制御機構の解明が、脳内Aβ量の減少によるADの予防・治療法の確立のために大きく貢献すると考えられる。昨年度の成果において、我々は、神経ペプチドの一つソマトスタチン(SST)が、脳内ネプリライシンの活性・発現を制御している因子として同定した。SSTは、ソマトスタチン受容体(SSTR)を介して様々な生理作用を発揮することが知られており、これまでに5種類が同定されている。もし、どのSSTRがネプリライシンの活性・発現を制御しているのかが明らかになれば、その特異的なアゴニストにより、ネプリライシンの活性を高め、効率的にAβ量を減少させることができ、かっ副作用も小さいと予想される。本申請課題では、SSTR3とSSTR4欠損マウスを用いて、これらの脳内におけるネプリライシンの活性・発現及びAβ量の定量を行った。その結果SSTR4欠損マウスでは、野生型と比較してネプリライシンの活性・発現、Aβ代謝に関する他の因子の活性等に差が認められないものの、脳内でのAβ42/Aβ40比が有意に増加していることが明ら...

アミロイドβ分解酵素ネプリライシンの発現及び活性制御機構の解明
文部科学省：科学研究費補助金(若手研究(B))
Date (from‐to) : 2003 -2004
Author : 斉藤貴志

アルツハイマー病(AD)は、脳内のアミロイドβ(Aβ)の過剰な蓄積に起因すると考えられており、この蓄積したAβ量を減少させることがADの治療、予防に有効であることが報告され始めている。我々が標的にしているネプリライシンは、脳内におけるAβ分解の主要プロテアーゼであり、この活性・発現制御機構の解明が、脳内Aβ量の減少によるADの治療・予防法の確立へ大きく貢献すると考えられる。本研究課題において、まずネプリライシンの活性・発現を制御する因子のスクリーニングを行った。我々が確立したネプリライシン活性染色法(ネプリライシン活性を視覚的にとらえる方法)によりスクリーニングを行った結果、唯一ソマトスタチンがネプリライシン活性を増加させることが明らかとなった。ソマトスタチンは、AD患者の脳内で減少している神経ペプチドの一つとしても知られている。初代培養神経細胞を用いてさらに検討を進めたところ、ソマトスタチンの効果はネプリライシン選択的であることが明らかとなり、ネプリライシン活性を賦活化することで培養上清中のAβ42レベルを低下させることが明らかとなった。そこで、ソマトスタチン欠損マウスを用いて解析を行った。その結果、ソマトスタチン欠損マウスでは脳内ネプリライシン活性が低下しており、その反作用として脳内Aβ量の増加が認められた。しかもそれはAβ42選択的であることが明らかとなった。さらに詳細...
アミロイドβ分解酵素ネプリライシンの発現及び活性制御機構の解明文部科学省：科学研究費補助金(若手研究(B))Date (from‐to) : 2003 -2004 Author : 斉藤貴志アルツハイマー病(AD)は、脳内のアミロイドβ(Aβ)の過剰な蓄積に起因すると考えられており、この蓄積したAβ量を減少させることがADの治療、予防に有効であることが報告され始めている。我々が標的にしているネ...See More
アミロイドβ分解酵素ネプリライシンの発現及び活性制御機構の解明
文部科学省：科学研究費補助金(若手研究(B))
Date (from‐to) : 2003 -2004
Author : 斉藤貴志

アルツハイマー病(AD)は、脳内のアミロイドβ(Aβ)の過剰な蓄積に起因すると考えられており、この蓄積したAβ量を減少させることがADの治療、予防に有効であることが報告され始めている。我々が標的にしているネプリライシンは、脳内におけるAβ分解の主要プロテアーゼであり、この活性・発現制御機構の解明が、脳内Aβ量の減少によるADの治療・予防法の確立へ大きく貢献すると考えられる。本研究課題において、まずネプリライシンの活性・発現を制御する因子のスクリーニングを行った。我々が確立したネプリライシン活性染色法(ネプリライシン活性を視覚的にとらえる方法)によりスクリーニングを行った結果、唯一ソマトスタチンがネプリライシン活性を増加させることが明らかとなった。ソマトスタチンは、AD患者の脳内で減少している神経ペプチドの一つとしても知られている。初代培養神経細胞を用いてさらに検討を進めたところ、ソマトスタチンの効果はネプリライシン選択的であることが明らかとなり、ネプリライシン活性を賦活化することで培養上清中のAβ42レベルを低下させることが明らかとなった。そこで、ソマトスタチン欠損マウスを用いて解析を行った。その結果、ソマトスタチン欠損マウスでは脳内ネプリライシン活性が低下しており、その反作用として脳内Aβ量の増加が認められた。しかもそれはAβ42選択的であることが明らかとなった。さらに詳細...

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