GOTO Toshihiko

Researcher Information

URL

http://www.med.nagoya-cu.ac.jp/inter3.dir/index.html

J-Global ID

• 201001045693157849

Research Interests

• 動脈硬化   心機能   不整脈   

Research Areas

• Life sciences / Cardiology

Published Papers

• A Case of Myocardial Infarction with Non-obstructive Coronary Arteries Complicated by a Ventricular Septal Rupture: The Challenge of Achieving Hemodynamic Stability Using Impella Devices.

  Masashi Yokoi; Tsuyoshi Ito; Yu Kawada; Junki Yamamoto; Toshiyuki Yamada; Shohei Kikuchi; Shuichi Kitada; Toshihiko Goto; Hideo Hattori; Hisao Suda; Yoshihiro Seo

  Internal medicine (Tokyo, Japan) 2024/04
• Hemodialysis-induced Myocardial Stunning with No Obstructive Coronary Artery Disease: Pathophysiological Significance of Coronary Microvascular Dysfunction

  Masashi Yokoi; Tsuyoshi Ito; Wataru Suzuki; Junki Yamamoto; Takafumi Nakayama; Taku Ichihashi; Shohei Kikuchi; Shuichi Kitada; Toshihiko Goto; Yoshihiro Seo

  Internal Medicine Japanese Society of Internal Medicine 0918-2918 2024
• Effects of beta-blocker withdrawal in patients with heart failure with preserved ejection fraction: A protocol for systematic review and meta-analysis

  Hidekatsu Fukuta; Toshihiko Goto; Takeshi Kamiya

  PLOS ONE Public Library of Science (PLoS) 18 (11) e0294347 - e0294347 2023/11
• Association of epicardial fat with cardiac structure and function and cardiovascular outcomes: A protocol for systematic review and meta-analysis

  Hidekatsu Fukuta; Toshihiko Goto; Takeshi Kamiya

  PLOS ONE Public Library of Science (PLoS) 18 (4) e0283482 - e0283482 2023/04
• Association Between Aortic Stiffness and Exercise Tolerance in Patients at the Risk Stage of Heart Failure.

  Tatsuya Mizoguchi; Tomonori Sugiura; Yu Kawada; Junki Yamamoto; Masashi Yokoi; Kosuke Nakasuka; Kento Mori; Shohei Kikuchi; Tsuyoshi Ito; Shuichi Kitada; Toshihiko Goto; Yoshihiro Seo

  Circulation journal : official journal of the Japanese Circulation Society 87 (8) 1075 - 1084 2023/03
• Malondialdehyde-Modified Low-Density Lipoprotein as a Predictor of Major Adverse Limb Events after Endovascular Therapy in Patients with Lower Extremity Arterial Disease.

  Masashi Yokoi; Tsuyoshi Ito; Yu Kawada; Tatsuya Mizoguchi; Junki Yamamoto; Kento Mori; Kosuke Nakasuka; Shohei Kikuchi; Hiroshi Fujita; Shuichi Kitada; Toshihiko Goto; Yoshihiro Seo

  Journal of atherosclerosis and thrombosis 2023/03
• Changes in Aortic Stiffness by Exercise and Exercise Tolerance in the Subclinical Risk Stages and Heart Failure Stage C(タイトル和訳中)

  溝口 達也; 瀬尾 由広; 後藤 利彦; 北田 修一; 伊藤 剛; 中須賀 公亮; 森 賢人; 横井 雅史; 山本 惇貴; 河田 侑; 大石 悠香子

  日本循環器学会学術集会抄録集 (一社)日本循環器学会 87回 OJ06 - 5 2023/03
• Association between Institutional Characteristics and Introduction of Secondary Prevention Implantable Cardioverter Defibrillator in Dialysis Patients: From a JROAD-DPC Registry(タイトル和訳中)

  中須賀 公亮; 加藤 真理奈; 新谷 康広; 河田 侑; 溝口 達也; 山本 惇貴; 横井 雅史; 森 賢人; 菊池 祥平; 伊藤 剛; 北田 修一; 後藤 利彦; 瀬尾 由広

  日本循環器学会学術集会抄録集 (一社)日本循環器学会 87回 PJ106 - 1 2023/03
• Characteristics of Dialysis Patients Who were Avoided for Secondary Prevention Implantable Cardioverter Defibrillator: From a JROAD-DPC Registry(タイトル和訳中)

  中須賀 公亮; 加藤 真理奈; 新谷 康広; 河田 侑; 溝口 達也; 山本 惇貴; 横井 雅史; 森 賢人; 菊池 祥平; 伊藤 剛; 北田 修一; 後藤 利彦; 瀬尾 由広

  日本循環器学会学術集会抄録集 (一社)日本循環器学会 87回 PJ111 - 6 2023/03
• Dementia is a Major Factor for Delaying Physical Ability Improvement in Very Elderly Heart Failure(タイトル和訳中)

  鶴田 芳朗; 北田 修一; 河田 侑; 鈴木 航; 山本 惇貴; 横井 雅史; 中須賀 公亮; 菊池 祥平; 伊藤 剛; 後藤 利彦; 瀬尾 由広

  日本循環器学会学術集会抄録集 (一社)日本循環器学会 87回 PJ008 - 3 2023/03
• Non-A Blood Type Is a Risk Factor for Poor Cardio-Cerebrovascular Outcomes in Patients Undergoing Dialysis.

  Takafumi Nakayama; Junki Yamamoto; Toshikazu Ozeki; Yoshiro Tsuruta; Masashi Yokoi; Tomonori Aoi; Yoshiko Mori; Mayuko Hori; Makoto Tsujita; Yuichi Shirasawa; Chika Kondo; Kaoru Yasuda; Minako Murata; Yuko Kinoshita; Shigeru Suzuki; Michio Fukuda; Chikao Yamazaki; Noriyuki Ikehara; Makoto Sugiura; Toshihiko Goto; Hiroya Hashimoto; Kazuhiro Yajima; Shoichi Maruyama; Kunio Morozumi; Yoshihiro Seo

  Biomedicines MDPI 11 (2) 2227-9059 2023/02 [Refereed]
  
• A Case of Intraprocedural Thrombotic Events During Percutaneous Coronary Intervention Due to Acquired Antithrombin Deficiency-related Heparin Resistance Successfully Treated with Antithrombin Gamma Supplementation

  Masashi Yokoi; Tsuyoshi Ito; Junki Yamamoto; Kento Mori; Kosuke Nakasuka; Hiroshi Fujita; Shuichi Kitada; Toshihiko Goto; Yoshihiro Seo

  Internal Medicine Japanese Society of Internal Medicine 0918-2918 2023
• Cardiac Magnetic Resonance Assessment of Acute Myocardial Infarction Involving the Right Ventricle

  Masashi Yokoi; Tsuyoshi Ito; Hiroshi Fujita; Shuichi Kitada; Toshihiko Goto; Yoshihiro Seo

  Circulation Journal Japanese Circulation Society 1346-9843 2022/09
• Reclassification of Heart Failure with Preserved Ejection Fraction Following Cardiac Sympathetic Nervous System Activation: A New Cutoff Value of 58%

  Toshihiko Goto; Takafumi Nakayama; Junki Yamamoto; Kento Mori; Yasuhiro Shintani; Shohei Kikuchi; Hiroshi Fujita; Hidekatsu Fukuta; Yoshihiro Seo

  Tomography MDPI AG 8 (3) 1595 - 1607 2022/06
• Clinical impact of the pathological quantification of myocardial fibrosis and infiltrating T lymphocytes using an endomyocardial biopsy in patients with hypertrophic cardiomyopathy

  Yasuhiro Shintani; Takafumi Nakayama; Ayako Masaki; Masashi Yokoi; Kazuaki Wakami; Tsuyoshi Ito; Toshihiko Goto; Tomonori Sugiura; Hiroshi Inagaki; Yoshihiro Seo

  International Journal of Cardiology Elsevier BV 0167-5273 2022/05
• Ventricular Sigmoid Septum as a Risk Factor for Anthracycline-Induced Cancer Therapeutics-Related Cardiac Dysfunction in Patients With Malignant Lymphoma.

  Takafumi Nakayama; Yoshiko Oshima; Yasuhiro Shintani; Junki Yamamoto; Masashi Yokoi; Tsuyoshi Ito; Kazuaki Wakami; Shuichi Kitada; Toshihiko Goto; Hiroya Hashimoto; Shigeru Kusumoto; Tomonori Sugiura; Shinsuke Iida; Yoshihiro Seo

  Circulation reports 4 (4) 173 - 182 2022/04
• Impact of left ventricular hypertrophy on clinical outcomes in patients with dialysis: a single-center study in Japan.

  Takafumi Nakayama; Junki Yamamoto; Toshikazu Ozeki; Kaoru Yasuda; Chikao Yamazaki; Tsuyoshi Ito; Toshihiko Goto; Shoichi Maruyama; Kunio Morozumi; Yoshihiro Seo

  Journal of medical ultrasonics (2001) 49 (2) 241 - 252 2022/03
• Left Atrial Function Assessed by 3-dimensional Echocardiography is Useful for Predicting Future Heart Failure in Patients with Coronary Artery Disease(和訳中)

  若見 和明; 伴野 智幸; 菊池 祥平; 藤田 浩志; 後藤 利彦; 福田 英克; 大手 信之; 瀬尾 由広

  日本循環器学会学術集会抄録集 (一社)日本循環器学会 86回 JO01 - 3 2022/03
• Multimorbidity, polypharmacy, and mortality in older patients with pacemakers

  Toshihiko Goto; Kento Mori; Takafumi Nakayama; Junki Yamamoto; Yasuhiro Shintani; Kazuaki Wakami; Hidekatsu Fukuta; Yoshihiro Seo; Nobuyuki Ohte

  Journal of Arrhythmia Wiley 38 (1) 145 - 154 1880-4276 2022/02
• Effects of catheter-based renal denervation on heart failure with reduced ejection fraction: a meta-analysis of randomized controlled trials

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Takeshi Kamiya; Nobuyuki Ohte

  Heart Failure Reviews Springer Science and Business Media LLC 27 (1) 29 - 36 1382-4147 2022/01
• Non-Invasive Estimation of Left Ventricular Filling Pressure Based on Left Atrial Area Strain Measured With Transthoracic 3-Dimensional Speckle Tracking Echocardiography in Patients With Coronary Artery Disease.

  Tomoyuki Banno; Kazuaki Wakami; Shohei Kikuchi; Hiroshi Fujita; Toshihiko Goto; Hidekatsu Fukuta; Yoshihiro Seo; Nobuyuki Ohte

  Circulation reports 3 (9) 520 - 529 2021/09
• Autonomic regulation device therapy in patients with heart failure with preserved ejection fraction

  Hidekatsu Fukuta; Toshihiko Goto; Takeshi Kamiya

  Medicine: Case Reports and Study Protocols Ovid Technologies (Wolters Kluwer Health) 2 (9) e0150 - e0150 2021/09
• Correlation Between Longitudinal Strain in the Apical Segments of the Left Ventricle at End-Systole Obtained by 2-Dimensional Speckle-Tracking Echocardiography and Left Ventricular Relaxation.

  Keisuke Muto; Kazuaki Wakami; Junki Yamamoto; Tomoyuki Banno; Shohei Kikuchi; Toshihiko Goto; Hidekatsu Fukuta; Yoshihiro Seo; Nobuyuki Ohte

  Circulation journal : official journal of the Japanese Circulation Society 85 (9) 1575 - 1583 2021/08
• Cardiac β-Adrenergic Receptor Downregulation, Evaluated by Cardiac PET, in Chronotropic Incompetence.

  Toshihiko Goto; Shohei Kikuchi; Kento Mori; Takafumi Nakayama; Hidekatsu Fukuta; Yoshihiro Seo; Hitomi Narita; Akihiko Iida; Nobuyuki Ohte

  Journal of nuclear medicine : official publication, Society of Nuclear Medicine 62 (7) 996 - 998 2021/07
• Impact of differences in embryonic origin on the electrical features of the giant right atrium in an elderly patient.

  Toshihiko Goto; Kento Mori; Yoshimasa Murakami; Nobuyuki Ohte

  HeartRhythm case reports 7 (7) 496 - 497 2021/07
• 経カテーテル大動脈弁留置術後の大動脈圧およびstiffnessの短期変化に関する評価(Evaluation of Short-term Changes in Aortic Pressure and Stiffness after Transcatheter Aortic Valve Implantation)

  藤田 浩志; 杉浦 知範; 溝口 達也; 伊藤 剛; 新谷 康広; 山本 惇貴; 菊池 祥平; 若見 和明; 中山 貴文; 後藤 利彦; 瀬尾 由広; 大手 信之

  日本循環器学会学術集会抄録集 (一社)日本循環器学会 85回 OJ88 - 3 2021/03
• Sympathetic Nervous Denervation of Left Ventricle in Heart Failure with Preserved Ejection Fraction(和訳中)

  菊池 祥平; 北田 修一; 後藤 利彦; 瀬尾 由広; 大手 信之

  日本循環器学会学術集会抄録集 (一社)日本循環器学会 85回 OJ75 - 4 2021/03
• Transcatheter interatrial shunt device for the treatment of heart failure with preserved ejection fraction: a protocol for meta-analysis

  Hidekatsu Fukuta; Toshihiko Goto; Takeshi Kamiya

  INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols 2021/02
• Effect of beta-blockers on heart failure severity in patients with heart failure with preserved ejection fraction: a meta-analysis of randomized controlled trials.

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Takeshi Kamiya; Nobuyuki Ohte

  Heart failure reviews 26 (1) 165 - 171 2021/01
• Clinical features of anthracycline-induced cardiotoxicity in patients with malignant lymphoma who received a CHOP regimen with or without rituximab: A single-center, retrospective observational study.

  Takafumi Nakayama; Yoshiko Oshima; Shigeru Kusumoto; Junki Yamamoto; Satoshi Osaga; Haruna Fujinami; Takaki Kikuchi; Tomotaka Suzuki; Haruhito Totani; Shiori Kinoshita; Tomoko Narita; Asahi Ito; Masaki Ri; Hirokazu Komatsu; Kazuaki Wakami; Toshihiko Goto; Tomonori Sugiura; Yoshihiro Seo; Nobuyuki Ohte; Shinsuke Iida

  EJHaem 1 (2) 498 - 506 2020/11
• Transmission Rate of Remote Monitoring and Mortality in Patients With Pacemaker.

  Toshihiko Goto; Kento Mori; Takafumi Nakayama; Junki Yamamoto; Yasuhiro Shintani; Kosuke Nakasuka; Kazuaki Wakami; Hidekatsu Fukuta; Yoshihiro Seo; Nobuyuki Ohte

  Circulation reports 2 (9) 471 - 478 2020/08
• Effect of renin-angiotensin system inhibition on cardiac structure and function and exercise capacity in heart failure with preserved ejection fraction: a meta-analysis of randomized controlled trials.

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Takeshi Kamiya; Nobuyuki Ohte

  Heart failure reviews 2020/06
• Remote Management of Pacemaker Patients With Biennial In-Clinic Evaluation: Continuous Home Monitoring in the Japanese At-Home Study: A Randomized Clinical Trial.

  Eiichi Watanabe; Fumio Yamazaki; Toshihiko Goto; Toru Asai; Toshihiko Yamamoto; Keiji Hirooka; Toshiaki Sato; Atsunobu Kasai; Marehiko Ueda; Takeshi Yamakawa; Yasunori Ueda; Katsuhito Yamamoto; Takeshi Tokunaga; Yoshinao Sugai; Kazuhiko Tanaka; Shigeki Hiramatsu; Tomoharu Arakawa; Jürgen Schrader; Niraj Varma; Kenji Ando

  Circulation. Arrhythmia and electrophysiology 13 (5) e007734  2020/05
• Physical activity and mortality in older patients with a pacemaker.

  Toshihiko Goto; Kento Mori; Kosuke Nakasuka; Marina Kato; Takafumi Nakayama; Tomoyuki Banno; Taku Ichihashi; Kazuaki Wakami; Hidekatsu Fukuta; Yoshihiro Seo; Nobuyuki Ohte

  Geriatrics & gerontology international 20 (2) 106 - 111 2020/02
• Verification of Echocardiographic Assessment of Left Ventricular Diastolic Dysfunction in Patients With Preserved Left Ventricular Ejection Fraction Using the American Society of Echocardiography and European Association of Cardiovascular Imaging 2016 Recommendations.

  Junki Yamamoto; Kazuaki Wakami; Keisuke Muto; Shohei Kikuchi; Toshihiko Goto; Hidekatsu Fukuta; Yoshihiro Seo; Nobuyuki Ohte

  Circulation reports 1 (11) 525 - 530 2019/10
• [Locally Advanced Sigmoid Colon Cancer in an Elderly Patient Treated with Curative Resection after Successful Panitumumab Treatment].

  Toshihiko Goto; Masahiko Okamura; Kunihiko Tsuboi; You Mizukami; Shuichi Ota; Yukito Adach

  Gan to kagaku ryoho. Cancer & chemotherapy 46 (8) 1311 - 1313 0385-0684 2019/08
• Effects of exercise training on cardiac function, exercise capacity, and quality of life in heart failure with preserved ejection fraction: a meta-analysis of randomized controlled trials.

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Takeshi Kamiya; Nobuyuki Ohte

  Heart failure reviews 24 (4) 535 - 547 2019/07
• Effects of mineralocorticoid receptor antagonists on left ventricular diastolic function, exercise capacity, and quality of life in heart failure with preserved ejection fraction: a meta-analysis of randomized controlled trials.

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Takeshi Kamiya; Nobuyuki Ohte

  Heart and vessels 34 (4) 597 - 606 2019/04
• The effect of influenza vaccination on mortality and hospitalization in patients with heart failure: a systematic review and meta-analysis.

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Takeshi Kamiya; Nobuyuki Ohte

  Heart failure reviews 24 (1) 109 - 114 2019/01
• Compensatory Increase in Heart Rate Is Responsible for Exercise Tolerance among Male Patients with Permanent Atrial Fibrillation.

  Kento Mori; Toshihiko Goto; Junki Yamamoto; Keisuke Muto; Shohei Kikuchi; Kazuaki Wakami; Hidekatsu Fukuta; Nobuyuki Ohte

  The Tohoku journal of experimental medicine 246 (4) 265 - 274 2018/12
• Delayed right ventricular perforation complicated by intracardiac thrombosis after implantable cardioverter-defibrillator implantation.

  Tsuyoshi Ito; Toshihiko Goto; Yu Kawada; Nobuyuki Ohte

  Journal of arrhythmia 34 (1) 74 - 76 2018/02
• The effect of beta-blockers on mortality in heart failure with preserved ejection fraction: A meta-analysis of observational cohort and randomized controlled studies

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Nobuyuki Ohte

  INTERNATIONAL JOURNAL OF CARDIOLOGY ELSEVIER IRELAND LTD 228 4 - 10 0167-5273 2017/02 [Refereed]
  
• Vascular Physiology according to Clinical Scenario in Patients with Acute Heart Failure: Evaluation using the Cardio-Ankle Vascular Index

  Toshihiko Goto; Kazuaki Wakami; Kento Mori; Shohei Kikuchi; Hidekatsu Fukuta; Nobuyuki Ohte

  TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE TOHOKU UNIV MEDICAL PRESS 240 (1) 57 - 65 0040-8727 2016/09 [Refereed]
  
• The effect of statins on mortality in heart failure with preserved ejection fraction: a meta-analysis of propensity score analyses

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Nobuyuki Ohte

  INTERNATIONAL JOURNAL OF CARDIOLOGY ELSEVIER IRELAND LTD 214 302 - 307 0167-5273 2016/07 [Refereed]
  
• Patients with left ventricular ejection fraction greater than 58 % have fewer incidences of future acute decompensated heart failure admission and all-cause mortality

  Toshihiko Goto; Kazuaki Wakami; Hidekatsu Fukuta; Hiroshi Fujita; Tomomitsu Tani; Nobuyuki Ohte

  HEART AND VESSELS SPRINGER 31 (5) 734 - 743 0910-8327 2016/05 [Refereed]
  
• Effects of drug and exercise intervention on functional capacity and quality of life in heart failure with preserved ejection fraction: A meta-analysis of randomized controlled trials

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Nobuyuki Ohte

  EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY SAGE PUBLICATIONS LTD 23 (1) 78 - 85 2047-4873 2016/01 [Refereed]
  
• 血圧変動異常とその関連病態 心不全症例における血圧変動異常 左室駆出率保持症例vs左室収縮低下症例での比較

  後藤 利彦; 森 賢人; 蜂矢 健太; 永田 貴大; 菊池 祥平; 池原 典之; 若見 和明; 福田 英克; 山下 純世; 大手 信之

  日本心臓病学会学術集会抄録 (一社)日本心臓病学会 63回 754 - 754 2015/09
• Vector Flow Mapping is a Novel Useful Technique in Assessing Inertia Force of Late Systolic Aortic Flow and Left Ventricular Early Diastolic Function

  Kazuaki Wakami; Kenta Hachiya; Syunsuke Murai; Tsuyoshi Ito; Hiroshi Fujita; Toshihiko Goto; Hidekatsu Fukuta; Hidekatsu Fukuta; Tomomitsu Tani; Nobuyuki Ohte

  CIRCULATION LIPPINCOTT WILLIAMS & WILKINS 130 0009-7322 2014/11 [Refereed]
  
• Relation of epicardial fat to central aortic pressure and left ventricular diastolic function in patients with known or suspected coronary artery disease

  Kenta Hachiya; Hidekatsu Fukuta; Kazuaki Wakami; Toshihiko Goto; Tomomitsu Tani; Nobuyuki Ohte

  INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING SPRINGER 30 (7) 1393 - 1398 1569-5794 2014/10 [Refereed]
  
• 心臓交感神経の変時性不全のへの影響 123I-metaiodobenzylguanidine(MIBG)を用いた検討

  後藤 利彦; 加藤 孝記; 福田 英克; 山下 純世; 若見 和明; 蜂矢 健太; 菊池 祥平; 谷 智満; 大手 信之

  日本心臓病学会学術集会抄録 (一社)日本心臓病学会 62回 P - 119 2014/09
• Clinical Significance of Abnormal Relaxation Pattern of the Transmitral Flow Velocity Waveform in Older Patients With Preserved Left Ventricular Ejection Fraction

  Shohei Kikuchi; Kazuaki Wakami; Toshihiko Goto; Hidekatsu Fukuta; Hiroo Sonoda; Tomomitsu Tani; Nobuyuld Ohte

  CIRCULATION JOURNAL JAPANESE CIRCULATION SOC 77 (10) 2551 - 2557 1346-9843 2013/10 [Refereed]
  
• 拡張早期左室流入血流伝播速度は運動耐容能を規定する

  菊池 祥平; 池原 典之; 後藤 利彦; 若見 和明; 福田 英克; 大手 信之

  超音波医学 (公社)日本超音波医学会 40 (Suppl.) S464 - S464 1346-1176 2013/04
• Low cardiac output in a case of constrictive pericarditis with protein-losing enteropathy.

  Shohei Kikuchi; Nobuyuki Ohte; Kazuaki Wakami; Toshihiko Goto; Genjiro Kimura

  Internal medicine (Tokyo, Japan) 52 (1) 75 - 9 2013
• Midventricular Ballooning Takotsubo Cardiomyopathy Complicated by Transient Complete Atrioventricular Block

  Tomonori Sugiura; Yasuaki Dohi; Sumiyo Yamashita; Toshihiko Goto; Kenta Hachiya; Tomomitsu Tani; Yoshimasa Murakami; Nobuyuki Ohte

  INTERNAL MEDICINE JAPAN SOC INTERNAL MEDICINE 52 (17) 1919 - 1921 0918-2918 2013 [Refereed]
  
• Relationship Between Effective Arterial Elastance, Total Vascular Resistance, and Augmentation Index at the Ascending Aorta and Left Ventricular Diastolic Function in Older Women

  Toshihiko Goto; Nobuyuki Ohte; Hidekatsu Fukuta; Kazuaki Wakami; Tomomitsu Tani; Genjiro Kimura

  CIRCULATION JOURNAL JAPANESE CIRCULATION SOC 77 (1) 123 - 129 1346-9843 2013/01 [Refereed]
  
• Plasma N-Terminal Pro-Brain Natriuretic Peptide Levels Identifying Left Ventricular Diastolic Dysfunction in Patients With Preserved Ejection Fraction

  Hiroo Sonoda; Nobuyuki Ohte; Toshihiko Goto; Kazuaki Wakami; Hidekatsu Fukuta; Shohei Kikuchi; Tomomitsu Tani; Genjiro Kimura

  CIRCULATION JOURNAL JAPANESE CIRCULATION SOC 76 (11) 2599 - 2605 1346-9843 2012/11 [Refereed]
  
• Prognostic Value of Left Ventricular Diastolic Dysfunction in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease

  Hidekatsu Fukuta; Nobuyuki Ohte; Kazuaki Wakami; Toshihiko Goto; Tomomitsu Tani; Genjiro Kimura

  Cardiology Research and Practice Hindawi Limited 2012 1 - 8 2090-8016 2012
• Relation of Plasma Levels of Adiponectin to Left Ventricular Diastolic Dysfunction in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease

  Hidekatsu Fukuta; Nobuyuki Ohte; Kazuaki Wakami; Toshihiko Goto; Tomomitsu Tani; Genjiro Kimura

  AMERICAN JOURNAL OF CARDIOLOGY EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC 108 (8) 1081 - 1085 0002-9149 2011/10 [Refereed]
  
• Decreased plasma B-type natriuretic peptide levels in obesity are not explained by altered left ventricular hemodynamics

  Hidekatsu Fukuta; Nobuyuki Ohte; Kazuaki Wakami; Toshihiko Goto; Tomomitsu Tani; Genjiro Kimura

  OBESITY RESEARCH & CLINICAL PRACTICE ELSEVIER SCI LTD 5 (4) E351 - E359 1871-403X 2011/10 [Refereed]
  
• Reduced renal function is associated with combined increases in ventricular-systolic stiffness and arterial load in patients undergoing cardiac catheterization for coronary artery disease

  Hidekatsu Fukuta; Nobuyuki Ohte; Kazuaki Wakami; Kaoru Asada; Toshihiko Goto; Seiji Mukai; Genjiro Kimura

  HEART AND VESSELS SPRINGER 26 (1) 10 - 16 0910-8327 2011/01 [Refereed]
  
• Myocardial Fiber Shortening in the Circumferential Direction Produces Left Ventricular Wall Thickening during Contraction

  Takafumi Kato; Nobuyuki Ohte; Kazuaki Wakami; Toshihiko Goto; Hidekatsu Fukuta; Hitomi Narita; Genjiro Kimura

  TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE TOHOKU UNIV MEDICAL PRESS 222 (3) 175 - 181 0040-8727 2010/11 [Refereed]
  
• Impact of Arterial Load on Left Ventricular Diastolic Function in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease

  Hidekatsu Fukuta; Nobuyuki Ohte; Kazuaki Wakami; Kaoru Asada; Toshihiko Goto; Seiji Mukai; Tomomitsu Tani; Genjiro Kimura

  CIRCULATION JOURNAL JAPANESE CIRCULATION SOC 74 (9) 1900 - 1905 1346-9843 2010/09 [Refereed]
  
• Usefulness of Plasma Brain Natriuretic Peptide Measurement and Tissue Doppler Imaging in Identifying Isolated Left Ventricular Diastolic Dysfunction Without Heart Failure

  Toshihiko Goto; Nobuyuki Ohte; Kazuaki Wakami; Kaoru Asada; Hidekatsu Fukuta; Seiji Mukai; Tomomitsu Tani; Genjiro Kimura

  AMERICAN JOURNAL OF CARDIOLOGY EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC 106 (1) 87 - 91 0002-9149 2010/07 [Refereed]
  
• Relationship Between Renal Function, Aortic Stiffness and Left Ventricular Function in Patients With Coronary Artery Disease

  Hidekatsu Fukuta; Nobuyuki Ohte; Seiji Mukai; Kaoru Asada; Kazuaki Wakami; Toshihiko Goto; Genjiro Kimura

  CIRCULATION JOURNAL JAPANESE CIRCULATION SOC 73 (9) 1740 - 1745 1346-9843 2009/09 [Refereed]
  
• Correlation between Left Ventricular End-diastolic Pressure and Peak Left Atrial Wall Strain during Left Ventricular Systole

  Kazuaki Wakami; Nobuyuki Ohte; Kaoru Asada; Hidekatsu Fukuta; Toshihiko Goto; Seiji Mukai; Hitomi Narita; Genjiro Kimura

  JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY MOSBY-ELSEVIER 22 (7) 847 - 851 0894-7317 2009/07 [Refereed]
  
• Usefulness of plasma brain-type natriuretic peptide level to differentiate left ventricular diastolic dysfunction from preserved diastolic function in patients with systolic dysfunction

  Toshihiko Goto; Nobuyuki Ohte; Hiromichi Miyabe; Seiichiro Sakata; Kaoru Asada; Seiji Mukai; Junichiro Hayano; Genjiro Kimura

  American Journal of Cardiology 95 (11) 1383 - 1385 0002-9149 2005/06
• Tl-201 washout rate in remote normal regions in patients with prior myocardial infarction and left ventricular remodeling

  Toshihiko Goto; Nobuyuki Ohte; Hiromichi Miyabe; Seiji Mukai; Seiichiro Sakata; Junichiro Hayano; Genjiro Kimura

  Journal of Nuclear Cardiology 12 (2) 179 - 185 1071-3581 2005/03
• Evaluation of whole left ventricular systolic performance and local myocardial systolic function in patients with prior myocardial infarction using global long-axis myocardial strain

  Nobuyuki Ohte; Hitomi Narita; Hiromichi Miyabe; Norio Takada; Toshihiko Goto; Hiroumi Mizuno; Kaoru Asada; Junichiro Hayano; Genjiro Kimura

  American Journal of Cardiology 94 (7) 929 - 932 0002-9149 2004/10
• The Role of Apically Directed Intraventricular Isovolumic Relaxation Flow in Speeding Early Diastolic Left Ventricular Filling

  Atsumi Yanada; Nobuyuki Ohte; Hitomi Narita; Sachie Akita; Hiromichi Miyabe; Norio Takada; Toshihiko Goto; Seiji Mukai; Junichiro Hayano; Genjiro Kimura

  Journal of the American Society of Echocardiography 16 (12) 1226 - 1230 0894-7317 2003/12

MISC

• リードレスペースメーカ植込み後にたこつぼ様壁運動異常を認めた2例

  中須賀 公亮; 溝口 達也; 山本 惇貴; 加藤 真理奈; 横井 雅史; 森 賢人; 北田 修一; 後藤 利彦; 瀬尾 由広; 大手 信之  心臓  53-  (10)  1100  -1107  2021/10
• Effect of renin-angiotensin system inhibitors on mortality in heart failure with preserved ejection fraction: a meta-analysis of observational cohort and randomized controlled studies

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Nobuyuki Ohte  HEART FAILURE REVIEWS  22-  (6)  775  -782  2017/11
• Effects of catheter-based renal denervation on heart failure with reduced ejection fraction: a systematic review and meta-analysis

  Hidekatsu Fukuta; Toshihiko Goto; Kazuaki Wakami; Nobuyuki Ohte  HEART FAILURE REVIEWS  22-  (6)  657  -664  2017/11
• Intra Left Ventricular Pressure Gradient Obtained by Vector Flow Mapping is Useful to Assess Left Ventricular Suction and Relaxation

  Kazuaki Wakami; Shinro Saiki; Yu Kawada; Keisuke Muto; Junki Yamamoto; Hiroshi Fujita; Toshihiko Goto; Tomonori Sugiura; Hidekatsu Fukuta; Nobuyuki Ohte  CIRCULATION  134-  2016/11
• Intra Left Ventricular Pressure Gradient Obtained by Vector Flow Mapping is Useful to Assess Left Ventricular Suction and Relaxation

  Kazuaki Wakami; Shinro Saiki; Yu Kawada; Keisuke Muto; Junki Yamamoto; Hiroshi Fujita; Toshihiko Goto; Tomonori Sugiura; Hidekatsu Fukuta; Nobuyuki Ohte  CIRCULATION  134-  2016/11
• The Kinetic Energy of Left Ventricular Ejection Flow During Late Systole Produces Inertia Force of Late Systolic Aortic Flow and Good Left Ventricular Early Diastolic Function

  Junki Yamamoto; Kazuaki Wakami; Shohei Kikuchi; Syunsuke Murai; Hiroshi Fujita; Tomonori Sugiura; Toshihiko Goto; Nobuyuki Ohte  CIRCULATION  134-  2016/11
• Cardiac Sympathetic Nerve System Activity Evaluated by Cardiac I-123 Metaiodobenzylguanidine Scintigraphy in Heart Failure Patients With Preserved or Reduced Ejection Fraction

  Toshihiko Goto; Kazuaki Wakami; Kento Mori; Tomoyuki Banno; Shohei Kikuchi; Tomonori Sugiura; Hiroshi Fujita; Hidekatsu Fukuta; Nobuyuki Ohte  CIRCULATION  134-  2016/11
• Elevated Left Ventricular End Diastolic Pressure Reduces Intra Left Ventricular Pressure Gradient During Atrial Contraction

  Kazuaki Wakami; Marina Ishida; Tomoyuki Banno; Keisuke Muto; Junki Yamamoto; Shohei Kikuchi; Koji Yamamoto; Toshihiko Goto; Hidekatsu Fukuta; Nobuyuki Ohte  CIRCULATION  134-  2016/11
• Cardiac Sympathetic Nerve System Activity Evaluated by Cardiac I-123 Metaiodobenzylguanidine Scintigraphy in Heart Failure Patients With Preserved or Reduced Ejection Fraction

  Toshihiko Goto; Kazuaki Wakami; Kento Mori; Tomoyuki Banno; Shohei Kikuchi; Tomonori Sugiura; Hiroshi Fujita; Hidekatsu Fukuta; Nobuyuki Ohte  CIRCULATION  134-  2016/11
• Impact of Atrial Fibrillation on Exercise Intolerance in Patients With Preserved Left Ventricular Ejection Fraction

  Toshihiko Goto; Marina Ishida; Shohei Kikuchi; Kazuaki Wakami; Kento Mori; Hidekatsu Fukuta; Nobuyuki Ohte  CIRCULATION  134-  2016/11
• Determinants of Exercise Capacity in Patients with Preserved Left Ventricular Ejection Fraction and Reduced Left Ventricular Ejection Fraction

  Shohei Kikuchi; Noriyuki Ikehara; Kazuaki Wakami; Toshihiko Goto; Nobuyuki Ohte  JOURNAL OF CARDIAC FAILURE  21-  (10)  S168  -S169  2015/10
• Can Left Atrial Wall Area Strain Obtained by Three-dimensional Speckle Tracking Imaging Assess Left Ventricular Filling Pressure in Patients with Normal Left Ventricular Ejection Fraction?

  Noriyuki Ikehara; Kazuaki Wakami; Toshihiko Goto; Tomonori Sugiura; Hidekatsu Fukuta; Tomomitsu Tani; Nobuyuki Ohte  CIRCULATION  130-  2014/11
• Intraventricular Velocity Gradient of the Blood Flow during Isovolumic Relaxation is Useful to Assess Left Ventricular Suction

  Shohei Kikuchi; Kazuaki Wakami; Shuichi Kitada; Tomonori Sugiura; Toshihiko Goto; Tomomitsu Tani; Nobuyuki Ohte  CIRCULATION  130-  2014/11
• Left Atrial Wall Deformation Assessed by 3-Dimensional Speckle Tracking Imaging is a Useful Method in Assessing Left Ventricular Filling Pressure

  Kazuaki Wakami; Shohei Kikuchi; Shohei Kikuchi; Noriyuki Ikehara; Toshihiko Goto; Tomonori Sugiura; Hidekatsu Fukuta; Tomomitsu Tani; Nobuyuki Ohte  CIRCULATION  130-  2014/11
• Impact of Aortic Stiffness on Exercise Intolerance in Patients With Reduced Left Ventricular Ejection Fraction

  Toshihiko Goto; Kazuaki Wakami; Noriyuki Ikehara; Syohei Kikuchi; Takafumi Kato; Hidekatsu Fukuta; Nobuyuki Ohte  CIRCULATION  128-  (22)  2013/11
• Left Ventricular Relaxation is a More Important Determinant of Exercise Capacity than Left Atrial Reservoir Function in Patients With Preserved Left Ventricular Ejection Fraction

  Shohei Kikuchi; Noriyuki Ikehara; Toshihiko Goto; Kazuaki Wakami; Nobuyuki Ohte  CIRCULATION  128-  (22)  2013/11
• Elevated Left Ventricular End Diastolic Pressure Reduces Intraventricular Velocity Gradient of Blood Flow During Atrial Contraction

  Nobukatsu Akita; Nobuyuki Ohte; Hiroo Sonoda; Takafumi Kato; Hiroshi Fujita; Kazuaki Wakami; Toshihiko Goto; Hidekatsu Fukuta; Tomomitsu Tani; Genjiro Kimura  CIRCULATION  126-  (21)  2012/11
• Is Left Ventricular Area Strain obtained by Three-dimensional Ultrasound Speckle Tracking Imaging Useful in Assessing the Magnitudes of Inertia Force of Late Systolic Aortic Flow and Left Ventricular Elastic Recoil?

  Kazuaki Wakami; Nobuyuki Ohte; Takafumi Nakayama; Takafumi Kato; Tomonori Sugiura; Hiroshi Fujita; Toshihiko Goto; Hidekatsu Fukuta; Tomomitsu Tani; Genjiro Kimura  CIRCULATION  124-  (21)  2011/11
• Intraventricular Velocity Gradient of the Ejecting Blood Flow at Late Systole is a Novel Index in Assessing Inertia Force of Late Systolic Aortic Flow and Left Ventricular Early Diastolic Function

  Nobukatsu Akita; Nobuyuki Ohte; Kazuaki Wakami; Tomonori Sugiura; Toshihiko Goto; Hidekatsu Fukuta; Sumiyo Yamashita; Tomomitsu Tani; Genjiro Kimura  CIRCULATION  122-  (21)  2010/11
• Cardiac beta-adrenergic Receptor Density and Myocardial Systolic Function in Patients with Prior Myocardial Infarction and Left Ventricular Remodeling

  Nobuyuki Ohte; Hitomi Narita; Hidekatsu Fukuta; Akihiko Iida; Kazuaki Wakami; Toshihiko Goto; Tomomitsu Tani; Genjiro Kimkura  CIRCULATION  122-  (21)  2010/11
• Low Vitamin D and High Parathyroid Hormone levels Are Associated with Left Ventricular Dysfunction but Not with Increased Aortic Stiffness in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease.

  Hidekatsu Fukuta; Nobuyuki Ohte; Kazuaki Wakami; Toshihiko Goto; Seiji Mukai; Tomomitsu Tani; Genjiro Kimura  JOURNAL OF CARDIAC FAILURE  16-  (8)  S32  -S32  2010/08
• Clinical Significance of the Vortex Observed in the Left Ventricle at End Diastole

  Kazuaki Wakami; Nobuyuki Ohte; Chika Kato; Kaoru Asada; Toshihiko Goto; Hidekatsu Fukuta; Sumiyo Yamashita; Tomomitsu Tani; Seiji Mukai; Genjiro Kimura  CIRCULATION  120-  (18)  S352  -S352  2009/11
• Impact of Arterial Load on Left Ventricular Diastolic Function in Patients Undergoing Cardiac Catheterization for Coronary Artery Disease

  Hidekatsu Fukuta; Nobuyuki Ohte; Seiji Mukai; Tomomitsu Tani; Shigehiro Tomimoto; Kaoru Asada; Toshihiko Goto; Tomonori Sugiura; Kazuaki Wakami; Hiroshi Fujita; Shuichi Kitada; Noriyuki Ikehara; Shunsuke Murai; Chika Kato; Toshimine Iga; Geni Kimura  CIRCULATION  120-  (18)  S741  -S741  2009/11
• OJ-218 Impaired Left Ventricular Systolic Function in the Remote Normal Wall in Patients with Prior Myocardial Infarction(OJ37,Echo/Doppler (Myocardium) (I),Oral Presentation (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Wakami Kazuaki; Oote Nobuyuki; Sakamoto Mari; Wakamatsu Yoshimasa; Kitada Shuichi; Ikehara Noriyuki; Asada Kaoru; Goto Toshihiko; Fukuta Hidekatsu; Mukai Seiji; Kimura Genjiro  Circulation journal : official journal of the Japanese Circulation Society  73-  341  -341  2009/03
• PJ-226 Echodynamography is a Novel Useful Technique in Assessing Inertia Force of Late Systolic Aortic Flow and Left Ventricular Diastolic Function(PJ038,Echo/Doppler (New Technology) 1 (I),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Wakami Kazuaki; Oote Nobuyuki; Katou Chika; Asada Kaoru; Goto Toshihiko; Fukuta Hidekatsu; Ito Tatsuya; Mukai Seiji; Suzuki Shougo; Kimura Genjiro  Circulation journal : official journal of the Japanese Circulation Society  73-  602  -602  2009/03
• PJ-079 Reduced Renal Function is Associated with Increases in Arterial Stiffness and Left Ventricular Contractility in Patients with Coronary Artery Disease(PJ013,Cardiac Function (Clinical) 1 (M),Poster Session (Japanese),The 73rd Annual Scientific Meeting of The Japanese Circulation Society)

  Fukuta Hidekatsu; Oote Nobuyuki; Mukai Seiji; Asada Kaoru; Wakami Kazuaki; Goto Toshihiko; Kimura Genjiro  Circulation journal : official journal of the Japanese Circulation Society  73-  565  -566  2009/03
• Reduced Renal Function Is Associated With Increases in Arterial Stiffness and Left Ventricular Contractility in Patients With Coronary Artery Disease: A Ventricular Arterial Coupling Pattern Similar to Heart Failure With Normal Ejection Fraction

  Hidekatsu Fukuta; Nobuyuki Ohte; Seiji Mukai; Kaoru Asada; Kazuaki Wakami; Toshihiko Goto; Genjiro Kimura  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY  53-  (10)  A160  -A160  2009/03
• Self-measured blood pressure in hypertensive patients: Characteristics of each reading in consecutive measurements

  S. Yamashita; Y. Dohi; T. Goto; H. Takase; T. Sugiura; G. Kimura  JOURNAL OF HYPERTENSION  26-  S485  -S485  2008/06
• PJ-331 Left Atrial Dimension in Detecting of Left Ventricular Diastolic Dysfunction in Patients with Preserved Systolic Function. Comparison with Tissue Doppler(Cardiac function, basic/clinical-4 (M) PJ56,Poster Session (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

  Goto Toshihiko; Ohte Nobuyuki; Miyabe Hiromichi; Saeki Tomoaki; Kobayashi Kenji; Mukai Seiji; Sakata Seiichiro; Asada Kaoru; Wakami Kazuaki; Mizuno Hiroumi; Kato Takafumi; Kimura Genjiro  Circulation journal : official journal of the Japanese Circulation Society  70-  571  -571  2006/03
• Thallium-201 Washout Rate on Remote-normal Regions in Patients with Prior Myocardial Infarction and Left Ventricular Remodeling (Old Myocardial Infarction/Remodeling 2 (IHD), The 69th Annual Scientific Meeting of the Japanese Circulation Society)

  Goto Toshihiko; Ohte Nobuyuki; Miyabe Hiromichi; Saeki Tomoaki; Mukai Seiji; Sakata Seiichiro; Asada Kaoru; Mizuno Hiromi; Katoh Takafumi; Kimura Genjiro  Circulation journal : official journal of the Japanese Circulation Society  69-  564  -564  2005/03
• PJ-317 Can Plasma BNP Level Differentiate Left Ventricular Diastolic Dysfunction from Preserved Diastolic Function in Patients with Impaired Systolic Function?(Heart Failure, Clinical 7 (M) : PJ53)(Poster Session (Japanese))

  Goto Toshihiko; Ohte Nobuyuki; Mukai Seiji; Yajima Kazuhiro; Sakata Seiichiro; Miyabe Hiromichi; Ishihara Shinji; Takada Norio; Asada Kaoru; Mizuno Hiroumi; Kimura Genjiro  Circulation journal : official journal of the Japanese Circulation Society  68-  558  -558  2004/03
• Myocardial Strain along the Left Ventricular Long-Axis Is a Superior Parameter of Global Left Ventricular Systolic Performance

  Ohte Nobuyuki; Narita Hitomi; Akita Sachie; Yajima Kazuhiro; Miyabe Hiromichi; Takada Norio; Goto Toshihiko; Kimura Genjiro  Circulation journal : official journal of the Japanese Circulation Society  67-  483  -483  2003/03
• Clinical Significances of ANP, BNP, and Adrenomedullin Levels in Patients with Asymptomatic Left Ventricular Dysfunction

  Takada Norio; Ohte Nobuyuki; Akita Sachie; Yajima Kazuhiro; Kurokawa Kazuyuki; Miyabe Hiromichi; Goto Toshihiko; Mukai Seiji; Kimura Genjiro  Circulation journal : official journal of the Japanese Circulation Society  67-  566  -567  2003/03

Research Grants & Projects

• Cardiac Beta-Adrenergic Receptor Density, Evaluated by Cardiac Positron Emission Tomography, in Heart Failure with Atrial Fibrillation

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2022/04 -2027/03 

  Author : 後藤 利彦
• PETを用いた変時性不全における心臓交感神経pre-synapse機能の研究

  日本学術振興会：科学研究費助成事業

  Date (from‐to) : 2018/04 -2023/03 

  Author : 後藤 利彦

   

  本研究「PETを用いた変時性不全における心臓交感神経pre-synapse機能の研究」において、C-11 hydroxyephedrine(HED)PETを用いて、変時性不全症例のpresynapse機能を定量評価した。Presynapse機能の定量評価には、HED心筋滞留率(HED-RI)を用いた。これは、トレーサー（C-11 HED）投与後30分から40分までの間の関心領域(ROI)内放射活性積分値の左室腔内中央に設定した小ROIにおける放射活性積分値に対する比率で算出される。これまで心不全症例においてはHED-RIの低下が報告されており、心臓交感神経終末におけるカテコラミンの保持に障害が生じていることを意味している。本研究においては、健常者6例と変時性不全例9例、合計15例においてPET検査を施行した。変時性不全群においてHED-RIは、健常者群と比較し有意に高値を示していた(変時性不全 vs 健常者; 13.8±3.0 vs. 8.5±3.9%/min, p = 0.01)。本研究の結果は、変時性不全においては心臓交感神経終末において適切なカテコラミン放出が行えないことを示唆しており、このことが変時性不全のメカニズムの一端に関与していることが推察された。
• Impact of cardiac beta-adrenergic receptor density evaluated by cardiac PET on chronotropic incompetence

  Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research

  Date (from‐to) : 2015/04 -2018/03 

  Author : Goto Toshihiko; KIKUCHI SHOHEI; IIDA AKIHIKO; NARITA HITOMI; ITO YOSHIMARO; HAYASHI EMI

   

  Chronotropic incompetence, defined as the inability of the heart to increase its rate commensurate with increased activity, produces exercise intolerance, and is an independent predictor of overall mortality. The cardiac sympathetic β adrenergic receptor density in patients with chronotropic incompetence was evaluated using cardiac PET using positron tracer [C11] CGP-12177 which is a ligand of the sympathetic β adrenergic receptor. In patients with chronotropic incompetence, the β adrenergic receptor density was decreased, and the decrease of cardiac β adrenergic receptor density, which is located in the post synapse was related as a cause of it. This study may help better understanding of the mechanism of chronotropic incompetence.

Other link

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https://researchmap.jp/read0152695