Researcher Database


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HOTTA Yuji

FacultyGraduate School of Pharmaceutical Sciences Department of Hospital Pharmacy
PositionAssistant Professor
Mailyhottaphar.nagoya-cu.ac.jp
HomepageURLhttp://www.med.nagoya-cu.ac.jp/pharmacy/index.html
Birthday
Last Updated :2019/10/12

Researcher Profile and Settings

Education

  •   2003 04  - 2007 03 , Nagoya City University

Association Memberships

  • The Japan Society for Sexual Medicine
  • International Society For Sexual Medicine (ISSM)
  • Asia Pacific Society For Sexual Medicine (APSSM)
  • The Japanese Continence Society
  • International Continence Sciety (ICS)
  • JAPANESE SOCIETY OF NEPHROLOGY
  • The Japanese Pharmacological Society
  • Japan Society of Smooth Muscle Research
  • The Pharmaceutical Society of Japan

Research Activities

Research Areas

  • Pharmacy, Medical pharmacy
  • Clinical surgery, Urology
  • Clinical internal medicine, Kidney internal medicine

Published Papers

  • Testosterone Deficiency and Endothelial Dysfunction: Nitric Oxide, Asymmetric Dimethylarginine, and Endothelial Progenitor Cells., Hotta Y, Kataoka T, Kimura K, Sexual medicine reviews, 04 , Refereed
  • Increase of arginine dimethylation correlates with the progression and prognosis of ALS., Ikenaka K, Atsuta N, Maeda Y, Hotta Y, Nakamura R, Kawai K, Yokoi D, Hirakawa A, Taniguchi A, Morita M, Mizoguchi K, Mochizuki H, Kimura K, Katsuno M, Sobue G, Neurology, 92, (16) e1868 - e1877, 04 , Refereed
  • In Cellullo and ex Vivo Availability of a Yellowish-Green-Light-Controllable NO Releaser., Ieda N, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H, Chemical & pharmaceutical bulletin, 67, (6) 576 - 579, Refereed
  • Hepatitis B infection reported with cancer chemotherapy: analyzing the US FDA Adverse Event Reporting System., Sanagawa A, Hotta Y, Kataoka T, Maeda Y, Kondo M, Kawade Y, Ogawa Y, Nishikawa R, Tohkin M, Kimura K, Cancer medicine, 7, (6) 2269 - 2279, 04 , Refereed
  • Investigation of tolerability and quality of life for carboplatin-based chemotherapy in an elderly urothelial carcinoma patient undergoing hemodialysis: a case report., Kondo M, Naiki T, Hotta Y, Yamamoto Y, Sugiyama Y, Yasui T, Kimura K, Journal of pharmaceutical health care and sciences, 4, Refereed
  • Testosterone Deficiency Causes Endothelial Dysfunction via Elevation of Asymmetric Dimethylarginine and Oxidative Stress in Castrated Rats., Kataoka T, Hotta Y, Maeda Y, Kimura K, The journal of sexual medicine, 14, (12) 1540 - 1548, 12 , Refereed
  • High salt loading induces urinary storage dysfunction via upregulation of epithelial sodium channel alpha in the bladder epithelium in Dahl salt-sensitive rats., Yamamoto S, Hotta Y, Maeda K, Kataoka T, Maeda Y, Hamakawa T, Shibata Y, Sasaki S, Ugawa S, Yasui T, Kimura K, Journal of pharmacological sciences, 135, (3) 121 - 125, 11 , Refereed
  • The impact of a solitary kidney on tolerability to gemcitabine plus cisplatin chemotherapy in urothelial carcinoma patients: a retrospective study., Kondo M, Hotta Y, Ando R, Yasui T, Kimura K, Cancer chemotherapy and pharmacology, 79, (5) 995 - 1001, 05 , Refereed
  • A yellowish-green-light-controllable nitric oxide donor based on N-nitrosoaminophenol applicable for photocontrolled vasodilation., Okuno H, Ieda N, Hotta Y, Kawaguchi M, Kimura K, Nakagawa H, Organic & biomolecular chemistry, 15, (13) 2791 - 2796, 03 , Refereed
  • Determination of methylmalonyl coenzyme A by ultra high-performance liquid chromatography tandem mass spectrometry for measuring propionyl coenzyme A carboxylase activity in patients with propionic acidemia., Gotoh K, Nakajima Y, Tajima G, Watanabe Y, Hotta Y, Kataoka T, Kawade Y, Sugiyama N, Ito T, Kimura K, Maeda Y, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1046, 195 - 199, 03 , Refereed
  • Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser., Hotta Y, Ieda N, Fukamoto A, Kataoka T, Kawade Y, Maeda Y, Nakagawa H, Kimura K, Investigative and clinical urology, 57, (3) 215 - 220, 05 , Refereed
  • Mineralocorticoid receptor stimulation induces urinary storage dysfunction via upregulation of epithelial sodium channel expression in the rat urinary bladder epithelium., Yamamoto S, Hotta Y, Maeda K, Kataoka T, Maeda Y, Hamakawa T, Sasaki S, Yasui T, Asai K, Kimura K, Journal of pharmacological sciences, 130, (4) 219 - 225, 04 , Refereed
  • Novel therapy for arteriogenic erectile dysfunction., Hotta Y, Kimura K, Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 147, (1) 31 - 34, 01 , Refereed
  • Kinetic and molecular orbital analyses of dicarboxylic acylcarnitine methylesterification show that derivatization may affect the screening of newborns by tandem mass spectrometry., Maeda Y, Nakajima Y, Gotoh K, Hotta Y, Kataoka T, Sugiyama N, Shirai N, Ito T, Kimura K, Bioorganic & medicinal chemistry letters, 26, (1) 121 - 125, 01 , Refereed
  • Assay for methylmalonyl coenzyme A mutase activity based on determination of succinyl coenzyme A by ultrahigh-performance liquid chromatography tandem mass spectrometry., Gotoh K, Nakajima Y, Tajima G, Hotta Y, Kataoka T, Kawade Y, Sugiyama N, Ito T, Kimura K, Maeda Y., Anal Bioanal Chem., 407, (18) 5281 - 5286, 07 , Refereed
  • Photomanipulation of vasodilation with a blue-light-controllable nitric oxide releaser., Ieda N, Hotta Y, Miyata N, Kimura K, Nakagawa H., J Am Chem Soc., 136, (19) 7085 - 7091, Refereed
  • Oral L-citrulline supplementation improves erectile function and penile structure in castrated rats., Hotta Y, Shiota A, Kataoka T, Motonari M, Maeda Y, Morita M, Kimura K., Int J Urol., 21, (6) 608 - 612, 06 , Refereed
  • Assessment of androgen replacement therapy for erectile function in rats with type 2 diabetes mellitus by examining nitric oxide-related and inflammatory factors., Kataoka T, Hotta Y, Maeda Y, Kimura K., J Sex Med., 11, (4) 920 - 929, 04 , Refereed
  • Oral L-citrulline supplementation improves erectile function in rats with acute arteriogenic erectile dysfunction., Shiota A, Hotta Y, Kataoka T, Morita M, Maeda Y, Kimura K., J Sex Med., 10, (10) 2423 - 2429, 10 , Refereed
  • Limited effect of testosterone treatment for erectile dysfunction caused by high-estrogen levels in rats., Kataoka T, Hotta Y, Ohno M, Maeda Y, Kimura K., Int J Impot Res., 25, (6) 201 - 205
  • Effects of Chronic Vardenafil Treatment Persist after End of Treatment in Rats with Acute Arteriogenic Erectile Dysfunction., Hotta Y, Ohno R, Kataoka T, Mikumo M, Takahata Y, Ohno M, Maeda Y, Kimura K., J Sex Med., 9, (7) 1782 - 1788, 07 , Refereed
  • Temporal changes in erectile function and endothelium-dependent relaxing response of corpus cavernosal smooth muscle after ischemia by ligation of bilateral internal iliac arteries in the rabbit., Abe Y, Hotta Y, Okumura K, Kataoka T, Maeda Y, Kimura K., J Pharmacol Sci., 120, (3) 250 - 253, Refereed
  • Chronic vardenafil treatment improves erectile function via structural maintenance of penile corpora cavernosa in rats with acute arteriogenic erectile dysfunction., Hotta Y, Hattori M, Kataoka T, Ohno R, Mikumo M, Maeda Y, Kimura K., J Sex Med., 8, (3) 705 - 711, 03 , Refereed

Misc

  • 【性機能障害と腎泌尿器疾患】性機能基礎研究の最前線, 堀田 祐志, 木村 和哲, 腎臓内科・泌尿器科, 8, (3) 246 - 250,   2018 09
  • PDE-5阻害薬の最近の動向 他疾患への応用と偽造品問題, 堀田 祐志, 冨田 なつみ, 木村 和哲, APJHP: 愛知県病院薬剤師会雑誌, 46, (2) 2 - 4,   2018 09
  • 性機能up date 血管内皮機能からEDをみる, 堀田祐志、木村和哲, 自律神経, 49巻, (2号) 71 - 73,   2012

Books etc

  • Bioenvironmental Issues Affecting Men’s Reproductive and Sexual Health, Yuji Hotta, Chapter 31.495-501., Elsevier publishing group/Academic Press ,   2017 11

Patents

  • 特願2016-168719, 特開2018-035086

Research Grants & Projects

  • 思春期の偏った食生活が将来の勃起機能に与える影響,   2012 04  - 2014 03 , 堀田祐志

Social Contribution Activities Information

Social Contribution

  • 医療薬学フォーラム2015/第23回クリニカルファーマシーシンポジウムでシンポジストとして講演, 公益社団法人日本薬学会医療薬科学部会,  - 2015 07 15 , 医療薬学フォーラム2015/第23回クリニカルファーマシーシンポジウムで「虚血に伴う勃起不全および下部尿路症状に対するPDE-5阻害剤の「連日」投与による効果」について講演
  • 第25回日本性機能学会中部総会でシンポジストとして講演, 東 治人,  - 2015 06 20 , 第25回日本性機能学会中部総会でシンポジストとして「勃起現象は何に制御されるか? 〜創薬へとつなげる標的分子〜」の講演を行った。
  • 14thAPSSMでシンポジストとして講演, 並木幹夫,  - 2013 06 02 , The 14th Biennial Meeting of the Asia-Pacific Society for Sexual Medicineにて『Effects of Oral l-Citrulline Supplementation on Erectile Dysfunction』というタイトルで講演
  • 第23回日本性機能学会東部総会、ランチョンセミナーの講師, 米澤章彦,   2013 03 09  - 2013 03 09 , ランチョンセミナー『性機能の最近の話題』『PDE5阻害剤の「連続」投与の効果とその可能性 − 動脈性EDモデルから得た知見 −』と題して講演を行った。
  • 第22回日本性機能学会中部総会シンポジウムのシンポジスト, 奥山明彦,   2012 08 04  - 2012 08 04 , シンポジウム『PDE5阻害剤無効例に対する対応—最新の知見を交えて-』S-3. 『シトルリンによるED改善の効果について』を講演した。
  • チーム医療に貢献する薬局薬剤師の養成事業広報委員, 大学,   2012 04  - 2013 03 , チーム医療に貢献する薬局薬剤師の養成事業の広報委員を務めた。


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