Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
Date (from‐to) : 2016/04 -2018/03
Author : KATAOKA TOMOYA; FUKAMOTO Ayako; ASANO Gakuto; HIDAKA Junya; SUZUKI Jun; HOTTA Yuji; MAEDA Yasuhiro; KIMURA Kazunori
We made sleep disorder model rats and investigated the effect on the sexual function. Normally, rats were raised under a light / dark cycle every 12 hours, but a chronic jet lag (CJL) treatment was performed which performed a process of advancing the light / dark cycle by 8 hours every 2 days. The ICP/MAP ratio was 0.81 ± 0.12 at 1 week after CJL treatment, and no change was observed. In addition, after 2 weeks it was 0.73 ± 0.12, which did not change, but after 4 weeks a significant decrease of 0.35 ± 0.05 was observed. When the expression of eNOS and phosphorylated eNOS was examined by western blotting method using the corpus cavernosum of rats 4 weeks after CJL treatment, significant decreases were observed in the CJL treatment group.