Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2019/04 -2022/03
Author : Sugiyama Daisuke
We need specific receptors to sense temperature. In this study, we focused on the TRPV1 receptor, which is known to enhance immune responses, and examined whether activated TRPV1 signaling enhances the efficacy of cancer immunotherapy. The results showed that administration of capsaicin, a TRPV1 ligand, to tumor-bearing mice augmented the therapeutic effect of anti-PD-1 antibody immunotherapy, suggesting the activation of CD8-positive T cells and antigen-presenting cells by enhancing TRPV1 signaling. The results of this study suggest that the TRPV1 signaling enhancement mechanism may be a new therapeutic approach for patients who do not respond to immunotherapy.