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TANAKA Masahiko

FacultyGraduate School of Pharmaceutical Sciences Department of Cellular Biophysics
PositionAssociate Professor
Mailmtanakaphar.nagoya-cu.ac.jp
HomepageURLhttp://www.nagoya-cu.ac.jp/phar/grad/soyaku/seimei/chobunshi.html
Birthday
Last Updated :2019/10/12

Researcher Profile and Settings

Education

  •   1985  - 1989 , The University of Tokyo, Faculty of Pharmaceutical Sciences, Division of Biophysical Science
  •   1989  - 1994 , The University of Tokyo, Graduate School of Pharmaceutical Sciences, Division of Biophysical Science

Association Memberships

  • Japan Neuroscience Society
  • Japanese Society for Neurochemistry
  • Society for Neuroscience
  • Biophysical Society of Japan
  • Pharmaceuitical Society of Japan
  • Molecular Biology Society of Japan

Committee Memberships

  • The Japanese Society for Neurochemistry, Councilor

Academic & Professional Experience

  •   1994  - 1998 , Fujita Health University, Division of Cell Biology, Institute for Comprehensive Medical Science, Assistant Professor
  •   1998  - 2006 , Fujita Health University, Division of Cell Biology, Institute for Comprehensive Medical Science, Lecturer
  •   2006 , Nagoya City University, Graduate School of Pharmaceutical Sciences, Associate Professor
  •   2007  - 現在, Nagoya City University, Department of Cellular Biophysics, Graduate School of Pharmaceutical Sciences, Associate Professor

Research Activities

Research Areas

  • Neuroscience, Nerve anatomy/Neuropathology
  • Neuroscience, Neurochemistry/Neuropharmacology
  • Basic medicine, Experimental pathology
  • Pharmacy, Biological pharmacy
  • Pharmacy, Physical pharmacy

Research Interests

    Neural network formation, Information processing system, Imaging, cerebellar Purkinje cell, glia

Published Papers

  • Calcineurin B1 deficiency in glial cells induces mucosal degeneration and inflammation in mouse small intestine, M Fujita, T Yagi, U Okura, J Tanaka, N Hirashima, M Tanaka, Biol. Pharm. Bull., 41, (5) 786 - 796, Refereed
  • Expression of the GluA2 subunit of glutamate receptors is required for the normal dendritic differentiation of cerebellar Purkinje cells, M Tanaka, T Senda, N Hirashima, Neurosci. Lett., 657, 22 - 26, Refereed
  • The dendritic differentiation of Purkinje neurons: unsolved mystery in formation of unique dendrites, M Tanaka, Cerebellum, 14, (3) 227 - 230, Refereed
  • Orai-2 is localized on secretary granules and regulates antigen-evoked Ca2+ mobilization and exocytosis in mast cells, M Ikeya, K Yamanoue, Y Mochizuki, H Konishi, S Tadokoro, M Tanaka, R Suzuki, N Hirashima, Biochem. Biophys. Res. Commun., 451, (1) 62 - 67, Refereed
  • ZIP2, a zinc transporter, is associated with keratinocyte differentiation, Y Inoue, S Hasegawa, S Ban, T Yamada, Y Date, H Mizutani, S Nakata, M Tanaka, N Hirashima, J. Biol. Chem., 289, (31) 21451 - 21462, Refereed
  • Optimization of single-cell electroporation protocol for forced gene expression in primary neuronal cultures, S Nishikawa, N Hirashima, M Tanaka, Mol. Biotechnol., 56, (9) 824 - 832, Refereed
  • Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells, R Ohashi, S Sakata, A Naito, N Hirashima, M Tanaka, Dev. Neurobiol., 74, (4) 467 - 480, Refereed
  • Detection of asymmetric distribution of phospholipids by fluorescent resonance energy transfer, Y Nishimura, S Tadokoro, M Tanaka, N Hirashima, Biochem. Biophys. Res. Commun., 420, (4) 926 - 930, Refereed
  • Long-term gene-silencing effects of siRNA introduced by single-cell electroporation into postmitotic CNS neurons, M Tanaka, M Asaoka, Y Yanagawa, N Hirashima, Neurochem. Res., 36, (8) 1482 - 1489, Refereed
  • A role of myosin Va in cerebellar plasticity and motor learning: a possible mechanism underlying neurological disorder in myosin Va disease, M Miyata, Y Kishimoto, M Tanaka, K Hashimoto, N Hirashima, Y Murata, M Kano, Y Takagishi, J. Neurosci., 31, (16) 6067 - 6078, Refereed
  • 培養神経細胞におけるGFPイメージングを用いた単一細胞レベルでのRNA干渉効果の解析, 田中正彦, バイオイメージング, 19, 9 - 13
  • Involvement of ELKS, an active zone protein, in exocytotic release from RBL-2H3 cells, H Nomura, T Ohtsuka, S Tadokoro, M Tanaka, N Hirashima, Cell. Immunol., 258, (2) 204 - 211, Refereed
  • Effects of 1-naphthyl acetyl spermine on dendrite formation by cultured cerebellar Purkinje cells, M Tanaka, S Sakata, N Hirashima, Neurosci. Lett., 462, (1) 30 - 32, Refereed
  • Transfer of small interfering RNA by single-cell electroporation in cerebellar cell cultures, M Tanaka, Y Yanagawa, N Hirashima, J. Neurosci. Meth., 178, (1) 80 - 86, Refereed
  • Dendrite formation of cerebellar Purkinje cells, M Tanaka, Neurochem. Res., 34, (12) 2078 - 2088, Refereed
  • Asymmetric localization of Notch2 on the microvillous surface in choroid plexus epithelial cells, M Tanaka, M Kokubo, T Marunouchi, Histochem. Cell Biol., 127, (4) 449 - 456, Refereed
  • 小脳プルキンエ細胞樹状突起の形態形成のメカニズム:受容体型チロシンホスファターゼPTPzの役割を中心として, 田中正彦, 日本神経精神薬理学雑誌, 27, (3) 135 - 140
  • Homer proteins control neuronal differentiation through IP3 receptor signaling, M Tanaka, RS Duncan, N McClung, J-AS Yannazzo, T Marunouchi, K Inokuchi, P Koulen, FEBS Lett., 580, (26) 6145 - 6150, Refereed
  • Dendritic morphogenesis of cerebellar Purkinje cells through extension and retraction revealed by long-term tracking of living cells in vitro., M Tanaka, Y Yanagawa, K Obata, T Marunouchi, Neuroscience, 141, (2) 663 - 674, Refereed
  • 神経樹状突起の形成メカニズム, 田中正彦, Priming BioMedicine, 2, 23 - 35
  • Developmental change and function of chondroitin sulfate deposited around cerebellar Purkinje cells, Y Shimazaki, I Nagata, M Tanaka, T Marunouchi, T Hata, N Maeda, J. Neurosci. Res., 82, (2) 172 - 183, Refereed
  • Abnormality in the cerebellar folial pattern of C57BL/6J mice, M Tanaka, T Marunouchi, Neurosci. Lett., 390, (3) 182 - 186, Refereed
  • Immunohistochemical localization of Notch receptors and their ligands in the postnatally developing rat cerebellum, M Tanaka, T Marunouchi, Neurosci. Lett., 353, (2) 87 - 90, Refereed
  • A chondroitin sulfate proteoglycan PTPz/RPTPb regulates the morphogenesis of Purkinje cell dendrites in the developing cerebellum, M Tanaka, N Maeda, M Noda, T Marunouchi, J. Neurosci., 23, (7) 2804 - 2814, Refereed
  • 小脳切片培養系を用いた神経系細胞の増殖・移動・分化・細胞死の機構解析, 田中正彦, 神経化学, 40, (4) 56 - 582
  • In situ detection of activated caspase-3 in apoptotic granuleneurons in the developing cerebellum in slice cultures and in vivo, M Tanaka, T Momoi, T Marunouchi, Dev. Brain Res., 121, (2) 223 - 228, Refereed
  • Notch2 expression negatively correlates with glial differentiation in the postnatal mouse brain, M Tanaka, Y Kadokawa, Y Hamada, T Marunouchi, J. Neurobiol., 41, (4) 524 - 539, Refereed
  • Insulin-like growth factor-I analogue prevents apoptosis mediated through an interleukin-1b converting enzyme (caspase-1)-like protease of cerebellar external granular layer neurons : Developmental stage-specific mechanisms of neuronal cell death, M Tanaka, M Sawada, M Miura, T Marunouchi, Neuroscience, 84, (1) 89 - 100, Refereed
  • Immunohistochemical analysis of developmental stage of external granular layer neurons which undergo apoptosis in postnatal rat cerebellum, M Tanaka, T Marunouchi, Neurosci. Lett., 242, (2) 85 - 88, Refereed
  • Expression of Ly-6C on microglia in the developing and adult mouse brain, M Tanaka, T Marunouchi, M Sawada, Neurosci. Lett., 239, (1) 17 - 20, Refereed
  • ER-MP抗原陽性ミクログリアの存在について, 大橋鉱二,田中正彦,澤田誠,丸野内棣, Tiss. Cult. Res. Commun., 15, 221 - 227
  • Insulin prevents apoptosis of external granular layer neurons in rat cerebellar slice cultures, M Tanaka, M Sawada, S Yoshida, F Hanaoka, T Marunouchi, Neurosci. Lett., 199, (1) 37 - 40, Refereed
  • Roles of endogenous nitric oxide in cerebellar cortical development in slice cultures, M Tanaka, S Yoshida, M Yano, H Shimizu, Neuroreport, 5, (16) 2049 - 2052, Refereed
  • Observation of the highly organized development of granule cells in rat cerebellar organotypiccultures, M Tanaka, A Tomita, S Yoshida, M Yano, H Shimizu, Brain Res., 641, (2) 319 - 327, Refereed

Books etc

  • Single-cell electroporation of siRNA in primary neuronal cultures, Springer, New York,   2012 , In: Controlled Genetic Manipulations (Morozov ed.), Neuromethods, Volume 65, pp. 129-139
  • Role of a chondroitin sulfate proteoglycan PTPz in dendrite development of cerebellar Purkinje cells, Research Signpost, Kerala, India,   2007 , In: Neural Proteoglycans (Maeda ed.), pp. 153-166

Awards & Honors

  •   2001 , Aword for Young Investigator of Japanese Society for Neurochemistry

Research Grants & Projects

  • 小脳プルキンエ細胞におけるリアノジン受容体を介した樹状突起形成制御機構の解明, 名古屋市立大学, 田中正彦
  • 小脳プルキンエ細胞が複雑かつ秩序立った形態の樹状突起を形成する分子機構の解析, 名古屋市立大学, 田中正彦
  • PTPz及びバーグマン・グリア細胞によるプルキンエ細胞樹状突起の形態形成制御機構, 藤田保健衛生大学, 田中正彦
  • 神経幹細胞の最終細胞分裂に及ぼす細胞内外因子の効果, 藤田保健衛生大学, 丸野内棣
  • 切片培養系を用いた小脳形成における生細胞動的観察系の開発と応用, 藤田保健衛生大学, 田中正彦
  • 脊椎動物の神経発生におけるNotch2の機能解析, 藤田保健衛生大学, 角川裕造
  • 小脳顆粒細胞のアポトーシスにおけるICEファミリープロテアーゼの関与と活性化機構, 藤田保健衛生大学, 田中正彦


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