Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2019/04 -2022/03
Author : Yumi Endo
In an analysis of 119 taxane-treated cases, Kaplan Meier analyses showed that higher APT6V1A mRNA expression levels were significantly associated with poorer DFS (P < 0.0001) and OS (P = 0.002). In 102 of these cases, protein expression could be analyzed by immunochemical staining, and DFS (P=0.08) tended to be worse prognosis in cases with high ATP6V1A protein expression, but there was no significant difference.
The effect of ATP6V1A knockdown was also examined using the breast cancer cell line T47D. siRNA reagents for ATP6V1A were introduced into T47D and ATP6V1A expression was reduced in a volume-dependent manner. The cell lines with lower expression of ATP6V1A showed lower proliferative capacity. However, the difference was not significant.