UTAGAWA　Tsuyoshi

Researcher Information

Degree

• Ph.D.（2004/03 The University of Tokyo）

J-Global ID

• 201801003813899873

Research Interests

• RNA   polyadenylation   translation   RNA stability   protein aggregation   quality control   ribsoome   neurodegeneration   mental retardation   cognitive function   synapse   RNA-binding proteins   mRNA医薬   

Research Areas

• Life sciences / Neuroscience - general
• Life sciences / Molecular biology

Academic & Professional Experience

• 2022/07 - Today  Nagoya City UniversityGraduate School of Pharmaceutical Sciences Department of Biological Chemistry准教授
• 2014/09 - 2022/06  Tohoku UniversityGraduate School of Pharmaceutical Sciences助教
• 2012/07 - 2014/08  Nagoya UniversityGraduate School of Medicine特任助教
• 2007/06 - 2012/06  University of Massachusetts Medical SchoolProgram in Molecular MedicinePostdoctoral
• 2004/04 - 2007/05  Kansas State UniversityDivision of BiologyResearch Associate

Education

• 2001/03 - 2004/03  東京大学大学院  新領域創成科学研究科  先端生命科学専攻 博士課程
• 1998/04 - 2000/03  Tokyo University of Agriculture and Technology  農学研究科  応用生物科学専攻 修士課程
• 1994/04 - 1998/03  Tokyo Gakugei University  Faculty of Education  物質生命科学科

Association Memberships

• THE JAPAN NEUROSCIENCE SOCIETY   THE RNA SOCIETY OF JAPAN   THE MOLECULAR BIOLOGY SOCIETY OF JAPAN   日本薬学会   日本生化学会   

Published Papers

• The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK.

  Satoshi Yokoi; Takuji Ito; Kentaro Sahashi; Masahiro Nakatochi; Ryoichi Nakamura; Genki Tohnai; Yusuke Fujioka; Shinsuke Ishigaki; Tsuyoshi Udagawa; Yuishin Izumi; Mitsuya Morita; Osamu Kano; Masaya Oda; Takefumi Sone; Hideyuki Okano; Naoki Atsuta; Masahisa Katsuno; Yohei Okada; Gen Sobue

  The Journal of neuroscience : the official journal of the Society for Neuroscience 42 (47) 8881 - 8896 2022/10
• Optimized protocol for tRNA identification in the ribosomal complexes from human cell lines

  Tsuyoshi Udagawa; Moeka Seki; Toshifumi Inada

  STAR Protocols Elsevier BV 2 (3) 100615 - 100615 2666-1667 2021/09 [Refereed]
  
• Failure to Degrade CAT-Tailed Proteins Disrupts Neuronal Morphogenesis and Cell Survival

  Tsuyoshi Udagawa; Moeka Seki; Taku Okuyama; Shungo Adachi; Tohru Natsume; Takuya Noguchi; Atsushi Matsuzawa; Toshifumi Inada

  Cell Reports Elsevier BV 34 (1) 108599 - 108599 2211-1247 2021/01 [Refereed]
  
• Ribosomal protein S7 ubiquitination during ER stress in yeast is associated with selective mRNA translation and stress outcome

  Yasuko Matsuki; Yoshitaka Matsuo; Yu Nakano; Shintaro Iwasaki; Hideyuki Yoko; Tsuyoshi Udagawa; Sihan Li; Yasushi Saeki; Tohru Yoshihisa; Keiji Tanaka; Nicholas T. Ingolia; Toshifumi Inada

  Scientific Reports Springer Science and Business Media LLC 10 (1) 19669 - 19669 2020/12 [Refereed]
  
• Genome-wide Survey of Ribosome Collision

  Peixun Han; Yuichi Shichino; Tilman Schneider-Poetsch; Mari Mito; Satoshi Hashimoto; Tsuyoshi Udagawa; Kenji Kohno; Minoru Yoshida; Yuichiro Mishima; Toshifumi Inada; Shintaro Iwasaki

  Cell Reports Elsevier BV 31 (5) 107610 - 107610 2211-1247 2020/05 [Refereed]
  
• TRIM48 Promotes ASK1 Activation and Cell Death through Ubiquitination-Dependent Degradation of the ASK1-Negative Regulator PRMT1

  Yusuke Hirata; Kazumi Katagiri; Keita Nagaoka; Tohru Morishita; Yuki Kudoh; Tomohisa Hatta; Isao Naguro; Kuniyuki Kano; Tsuyoshi Udagawa; Tohru Natsume; Junken Aoki; Toshifumi Inada; Takuya Noguchi; Hidenori Ichijo; Atsushi Matsuzawa

  CELL REPORTS CELL PRESS 21 (9) 2447 - 2457 2211-1247 2017/11 [Refereed]
  
• 3 ' UTR Length-Dependent Control of SynGAP Isoform alpha 2 mRNA by FUS and ELAV-like Proteins Promotes Dendritic Spine Maturation and Cognitive Function

  Satoshi Yokoi; Tsuyoshi Udagawa; Yusuke Fujioka; Daiyu Honda; Haruo Okado; Hirohisa Watanabe; Masahisa Katsuno; Shinsuke Ishigaki; Gen Sobue

  CELL REPORTS CELL PRESS 20 (13) 3071 - 3084 2211-1247 2017/09 [Refereed]
  
• Ubiquitination of stalled ribosome triggers ribosome-associated quality control

  Yoshitaka Matsuo; Ken Ikeuchi; Yasushi Saeki; Shintaro Iwasaki; Christian Schmidt; Tsuyoshi Udagawa; Fumiya Sato; Hikaru Tsuchiya; Thomas Becker; Keiji Tanaka; Nicholas T. Ingolia; Roland Beckmann; Toshifumi Inada

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 8 (1) 159  2041-1723 2017/07 [Refereed]
  
• Altered Tau Isoform Ratio Caused by Loss of FUS and SFPQ Function Leads to FTLD-like Phenotypes

  Shinsuke Ishigaki; Yusuke Fujioka; Yohei Okada; Yuichi Riku; Tsuyoshi Udagawa; Daiyu Honda; Satoshi Yokoi; Kuniyuki Endo; Kensuke Ikenaka; Shinnosuke Takagi; Yohei Iguchi; Naruhiko Sahara; Akihiko Takashima; Hideyuki Okano; Mari Yoshida; Hitoshi Warita; Masashi Aoki; Hirohisa Watanabe; Haruo Okado; Masahisa Katsuno; Gen Sobue

  CELL REPORTS CELL PRESS 18 (5) 1118 - 1131 2211-1247 2017/01 [Refereed]
  
• FUS regulates AMPA receptor function and FTLD/ALS-associated behaviour via GluA1 mRNA stabilization

  Tsuyoshi Udagawa; Yusuke Fujioka; Motoki Tanaka; Daiyu Honda; Satoshi Yokoi; Yuichi Riku; Daisuke Ibi; Taku Nagai; Kiyofumi Yamada; Hirohisa Watanabe; Masahisa Katsuno; Toshifumi Inada; Kinji Ohno; Masahiro Sokabe; Haruo Okado; Shinsuke Ishigaki; Gen Sobue

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 6 7098  2041-1723 2015/05 [Refereed]
  
• Lower Motor Neuron Involvement in TAR DNA-Binding Protein of 43 kDa-Related Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis

  Yuichi Riku; Hirohisa Watanabe; Mari Yoshida; Shinsui Tatsumi; Maya Mimuro; Yasushi Iwasaki; Masahisa Katsuno; Yohei Iguchi; Michihito Masuda; Jo Senda; Shinsuke Ishigaki; Tsuyoshi Udagawa; Gen Sobue

  JAMA NEUROLOGY AMER MEDICAL ASSOC 71 (2) 172 - 179 2168-6149 2014/02 [Refereed]
  
• The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons

  Daiyu Honda; Shinsuke Ishigaki; Yohei Iguchi; Yusuke Fujioka; Tsuyoshi Udagawa; Akio Masuda; Kinji Ohno; Masahisa Katsuno; Gen Sobue

  FEBS OPEN BIO WILEY 4 1 - 10 2211-5463 2014 [Refereed]
  
• The ALS/FTLD-related RNA-binding proteins TDP-43 and FUS have common downstream RNA targets in cortical neurons (vol 4, pg 1, 2014)

  Daiyu Honda; Shinsuke Ishigaki; Yohei Iguchi; Yusuke Fujioka; Tsuyoshi Udagawa; Akio Masuda; Kinji Ohno; Masahisa Katsuno; Gen Sobue

  FEBS OPEN BIO ELSEVIER SCIENCE LONDON 4 1030 - 1030 2211-5463 2014 [Refereed]
  
• FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD (vol 3, 2388, 2013)

  Yusuke Fujioka; Shinsuke Ishigaki; Akio Masuda; Yohei Iguchi; Tsuyoshi Udagawa; Hirohisa Watanabe; Masahisa Katsuno; Kinji Ohno; Gen Sobue

  SCIENTIFIC REPORTS NATURE PUBLISHING GROUP 3 2388  2045-2322 2013/11 [Refereed]
  
• Genetic and acute CPEB1 depletion ameliorate fragile X pathophysiology

  Tsuyoshi Udagawa; Natalie G. Farny; Mira Jakovcevski; Hanoch Kaphzan; Juan Marcos Alarcon; Shobha Anilkumar; Maria Ivshina; Jessica A. Hurt; Kentaro Nagaoka; Vijayalaxmi C. Nalavadi; Lori J. Lorenz; Gary J. Bassell; Schahram Akbarian; Sumantra Chattarji; Eric Klann; Joel D. Richter

  NATURE MEDICINE NATURE PUBLISHING GROUP 19 (11) 1473 - + 1078-8956 2013/11 [Refereed]
  
• Random mutagenesis of yeast 25S rRNA identify bases critical for 60S subunit structural integrity and function.

  Nemoto N; Udagawa T; Chowdhury W; Kitabatake M; Shin BS; Hiraishi H; Wang S; Singh CR; Brown SJ; Ohno M; Asano K

  Translation (Austin, Tex.) 1 (2) e26402  2169-074X 2013 [Refereed]
  
• Interaction between 25s rRNA a loop and eukaryotic translation initiation factor 5b promotes subunit joining and ensures stringent AUG selection

  Hiroyuki Hiraishi; Byung-Sik Shin; Tsuyoshi Udagawa; Naoki Nemoto; Wasimul Chowdhury; Jymie Graham; Christian Cox; Megan Reid; Susan J. Brown; Katsura Asano

  Molecular and Cellular Biology 33 (18) 3540 - 3548 0270-7306 2013 [Refereed]
  
• Erratum: FUS-regulated region- and cell-type-specific transcriptome is associated with cell selectivity in ALS/FTLD (Scientific Reports (2013) 3 (2388) DOI: 10.1038/srep02388)

  Yusuke Fujioka; Shinsuke Ishigaki; Akio Masuda; Yohei Iguchi; Tsuyoshi Udagawa; Hirohisa Watanabe; Masahisa Katsuno; Kinji Ohno; Gen Sobue

  Scientific Reports 3 2045-2322 2013 [Refereed]
  
• Specific miRNA Stabilization by Gld2-Catalyzed Monoadenylation

  Andrea D'Ambrogio; Weifeng Gu; Tsuyoshi Udagawa; Craig C. Mello; Joel D. Richter

  CELL REPORTS CELL PRESS 2 (6) 1537 - 1545 2211-1247 2012/12 [Refereed]
  
• Translational Control of Mitochondrial Energy Production Mediates Neuron Morphogenesis

  Aparna Oruganty-Das; Teclise Ng; Tsuyoshi Udagawa; Eyleen L. K. Goh; Joel D. Richter

  CELL METABOLISM CELL PRESS 16 (6) 789 - 800 1550-4131 2012/12 [Refereed]
  
• Bidirectional Control of mRNA Translation and Synaptic Plasticity by the Cytoplasmic Polyadenylation Complex

  Tsuyoshi Udagawa; Sharon A. Swanger; Koichi Takeuchi; Jong Heon Kim; Vijayalaxmi Nalavadi; Jihae Shin; Lori J. Lorenz; R. Suzanne Zukin; Gary J. Bassell; Joel D. Richter

  MOLECULAR CELL CELL PRESS 47 (2) 253 - 266 1097-2765 2012/07 [Refereed]
  
• CPEB-mediated ZO-1 mRNA localization is required for epithelial tight-junction assembly and cell polarity

  Kentaro Nagaoka; Tsuyoshi Udagawa; Joel D. Richter

  NATURE COMMUNICATIONS NATURE PUBLISHING GROUP 3 675  2041-1723 2012/02 [Refereed]
  
• The Roles of Stress-Activated Sty1 and Gcn2 Kinases and of the Protooncoprotein Homologue Int6/eIF3e in Responses to Endogenous Oxidative Stress during Histidine Starvation

  Naoki Nemoto; Tsuyoshi Udagawa; Takahiro Ohira; Li Jiang; Kouji Hirota; Caroline R. M. Wilkinson; Juerg Baehler; Nic Jones; Kunihiro Ohta; Ronald C. Wek; Katsura Asano

  JOURNAL OF MOLECULAR BIOLOGY ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD 404 (2) 183 - 201 0022-2836 2010/11 [Refereed]
  
• Yeast 18 S rRNA Is Directly Involved in the Ribosomal Response to Stringent AUG Selection during Translation Initiation

  Naoki Nemoto; Chingakham Ranjit Singh; Tsuyoshi Udagawa; Suzhi Wang; Elizabeth Thorson; Zachery Winter; Takahiro Ohira; Miki Ii; Leos Valasek; Susan J. Brown; Katsura Asano

  JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 285 (42) 32200 - 32212 0021-9258 2010/10 [Refereed]
  
• Int6/eIF3e promotes general translation and Atf1 abundance to modulate Sty1 MAPK-dependent stress response in fission yeast

  Tsuyoshi Udagawa; Naoki Nemoto; Caroline R. M. Wilkinson; Jana Narashimhan; Li Jiang; Stephen Watt; Aaron Zook; Nic Jones; Ronald C. Wek; Jurg Bahler; Katsura Asano

  JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 283 (32) 22063 - 22075 0021-9258 2008/08 [Refereed]
  
• Change in nutritional status modulates the abundance of critical pre-initiation intermediate complexes during translation initiation in vivo

  Chingakham Ranjit Singh; Tsuyoshi Udagawa; Bumjun Lee; Sarah Wassink; Hui He; Yasufumi Yamamoto; James T. Anderson; Graham D. Pavitt; Katsura Asano

  JOURNAL OF MOLECULAR BIOLOGY ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD 370 (2) 315 - 330 0022-2836 2007/07 [Refereed]
  
• Yeast phenotypic assays on translational control

  Bumiun Lee; Tsuyoshi Udagawa; Chingakham Ranjit Singh; Katsura Asano

  TRANSLATION INITIATION: EXTRACT SYSTEMS AND MOLECULAR GENETICS ELSEVIER ACADEMIC PRESS INC 429 105 - 137 0076-6879 2007 [Refereed]
  
• An eIF5/eIF2 complex antagonizes guanine nucleotide exchange by eIF2B during translation initiation

  Chingakham Ranjit Singh; Bumjun Lee; Tsuyoshi Udagawa; Sarah S. Mohammad-Qureshi; Yasufumi Yamamoto; Graham D. Pavitt; Katsura Asano

  EMBO JOURNAL NATURE PUBLISHING GROUP 25 (19) 4537 - 4546 0261-4189 2006/10 [Refereed]
  
• The wide distribution of endornaviruses, large double-stranded RNA replicons with plasmid-like properties

  T Fukuhara; R Koga; N Aoki; C Yuki; N Yamamoto; N Oyama; T Udagawa; H Horiuchi; S Miyazaki; Y Higashi; M Takeshita; K Ikeda; M Arakawa; N Matsumoto; H Moriyama

  ARCHIVES OF VIROLOGY SPRINGER WIEN 151 (5) 995 - 1002 0304-8608 2006/05 [Refereed]
  
• Evidence for the translation initiation of leaderless mRNAs by the intact 70 S ribosome without its dissociation into subunits in eubacteria

  T Udagawa; Y Shimizu; T Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC 279 (10) 8539 - 8546 0021-9258 2004/03 [Refereed]
  
• RNA-dependent RNA polymerase activity associated with endogenous double-stranded RNA in rice

  Hideki Horiuchi; Tsuyoshi Udagawa; Ryuichi Koga; Hiromitsu Moriyama; Toshiyuki Fukuhara

  Plant and Cell Physiology Japanese Society of Plant Physiologists 42 (2) 197 - 203 0032-0781 2001 [Refereed]
  

Books etc

• 化学便覧 応用化学編 第6版

  日本化学会 丸善出版 2003 9784621071380 1740 3

MISC

• 細胞質ポリアデニル化要素結合タンパク質

  宇田川剛  脳科学辞典  2023/05
• 小胞体ストレス応答におけるリボソームユビキチン化の新規機能

  松木泰子; 松尾芳隆; 岩崎信太郎; 岩崎信太郎; 横尾秀幸; 中野裕; 宇田川剛; 佐伯泰; 吉久徹; 田中啓二; INGOLIA Nicholas T; 稲田利文  日本RNA学会年会要旨集  21st-  139  2019/07
• RQC(Ribosome‐associated Quality Control)による翻訳停滞産物の分解は神経細胞の生存と形態形成に重要である。

  関萌香; 宇田川剛; 奥山卓; 足達俊吾; 夏目徹; 松沢厚; 野口拓也; 岡戸晴生; 稲田利文  日本RNA学会年会要旨集  21st-  42  2019/07
• 小胞体ストレス応答におけるリボソームユビキチン化の新規機能

  松木泰子; 松尾芳隆; 岩崎信太郎; 岩崎信太郎; 横尾秀幸; 中野裕; 宇田川剛; 佐伯泰; 吉久徹; 田中啓二; INGOLIA Nicholas T.; 稲田利文  日本薬学会東北支部大会講演要旨集  58th-  2019
• 小胞体ストレス応答におけるリボソームユビキチン化の新規機能

  松木泰子; 松尾芳隆; 岩崎信太郎; 横尾秀幸; 中野裕; 宇田川剛; 佐伯泰; 吉久徹; 田中啓二; INGOLIA Nicholas; 稲田利文  日本分子生物学会年会プログラム・要旨集(Web)  42nd-  2019
• 小胞体ストレス応答に関与する新規E3ユビキチン付加酵素の同定と機能解析

  中野裕; 松木泰子; 松尾芳隆; 横尾秀幸; 岩崎信太郎; 宇田川剛; 佐伯泰; 田中啓二; 稲田利文  日本薬学会東北支部大会講演要旨集  58th-  2019
• RQC(Ribosome-associated Quality Control)による翻訳停滞産物の分解は神経細胞の生存と形態形成に重要である。

  関萌香; 宇田川剛; 奥山卓; 足達俊吾; 夏目徹; 野口拓也; 松沢厚; 稲田利文  日本薬学会東北支部大会講演要旨集  58th-  2019
• 小胞体ストレス応答におけるリボソームユビキチン化の機能解析

  松木泰子; 松尾芳隆; 横尾秀幸; 岩崎信太郎; 宇田川剛; 佐伯泰; 田中啓二; INGOLIA Nicholas; 稲田利文  日本生化学会大会(Web)  90th-  ROMBUNNO.1P‐0555 (WEB ONLY)  -0555]  2017
• FUSの最近の話題

  宇田川剛  最新医学  71-  538  -541  2016
• 小胞体ストレス応答におけるリボソームユビキチン化の新規機能

  松木泰子; 松尾芳隆; 横尾秀幸; 宇田川剛; 岩崎信太郎; 佐伯泰; 田中啓二; INGOLIA Nicholas; 稲田利文  日本生化学会大会(Web)  89th-  ROMBUNNO.1T04‐05(1P‐032) (WEB ONLY)  2016
• 翻訳伸長異常に起因するフレームシフトとその制御機構

  坂本一真; 岸田菜摘; 牧野支保; 宇田川剛; 松尾芳隆; 佐伯泰; 岩崎信太郎; INGOLIA Nicholas; 田中啓二; 稲田利文  日本生化学会大会(Web)  89th-  ROMBUNNO.1P‐252 (WEB ONLY)  2016
• FUSはGluA1mRNA安定性の調節を介してシナプス機能及びFTLD/ALS様行動を制御する

  宇田川剛; 宇田川剛; 藤岡祐介; 田中基樹; 本田大祐; 横井聡; 衣斐大祐; 永井拓; 山田清文; 渡辺宏久; 勝野雅央; 大野欽司; 稲田利文; 曽我部正博; 岡戸晴生; 石垣診佑; 祖父江元  日本生化学会大会(Web)  88th-  2015
• CPEB1の枯渇は脆弱X精神遅滞症候群の病態生理を改善する

  宇田川剛  実験医学  32-  (4)  584  -587  2014
• FUSはGluR1 mRNAの安定化を介してAMPA受容体機能,及びALS/FTLD関連行動を制御する

  宇田川剛; 藤岡祐介; 田中基樹; 本田大祐; 横井聡; 衣斐大祐; 衣斐大祐; 永井拓; 永井拓; 山田清文; 山田清文; 勝野雅央; 曽我部正博; 岡戸晴生; 石垣診佑; 祖父江元  日本RNA学会年会要旨集  16th-  2014
• FUSはGluA1mRNA安定性の調節を介してシナプス機能及びFTLD様行動を制御する

  渡辺宏久; 宇田川剛; 藤岡祐介; 本田大祐; 横井聡; 石垣診佑; 田中基樹; 曽我部正博; 岡戸晴生; 祖父江元  Dementia Japan  28-  (4)  2014
• 細胞質ポリアデニル化複合体による樹状突起における翻訳とシナプス可塑性の双方向性の制御

  宇田川剛; Sharon A Swanger; Joel D Richter  ライフサイエンス新着論文レビュー  2012

Awards & Honors

• 2008/05 FRAXA Foundation Postdoctoral Fellowship
   

  受賞者: Tsuyoshi Udagawa

Research Grants & Projects

• 進化工学的アプローチによる人工 mRNA のタンパク質アミノ(N)末端領域の最適化

  ノバルティス科学振興財団：第36回ノバルティス研究奨励金

  Date (from‐to) : 2023/04 -2024/03
• 新生ペプチド鎖品質管理機構の破綻による細胞死誘導機構の解明

  文部科学省: 科学研究費補助金：基盤研究(C)

  Date (from‐to) : 2020/04 -2023/03
• Pathogenic mechanism of the psychiatric disorders caused by the failure of mRNA/protein quality control system

  Takeda Science Foundation：薬学系研究助成

  Date (from‐to) : 2020/09
• 異常タンパク質蓄積によるアポトーシス誘導機構および神経変性の分子機構の解明

  鈴木謙三記念応用医科学研究財団：研究助成

  Date (from‐to) : 2020/01
• 哺乳類神経細胞におけるmRNA・新生ペプチド鎖の品質管理とその生理的意義

  文部科学省: 科学研究費補助金：基盤研究(C)

  Date (from‐to) : 2016/04 -2019/03 

  Author : 宇田川 剛
• TDP-43・FUSによる翻訳・シナプス機能調節異常とALS・FTLD病態機序

  文部科学省: 科学研究費補助金：若手研究(B)

  Date (from‐to) : 2013/04 -2016/03 

  Author : 宇田川 剛
• mRNA品質管理因子による高次脳機能制御

  持田記念医学薬学振興財団：研究助成金

  Date (from‐to) : 2015 -2016 

  Author : 宇田川 剛

Other link

researchmap

https://researchmap.jp/TsuyoshiUdagawa