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YUASA Hiroaki

FacultyGraduate School of Pharmaceutical Sciences Department of Biopharmaceutics
PositionProfessor
Mailyuasaphar.nagoya-cu.ac.jp
HomepageURLhttp://www.phar.nagoya-cu.ac.jp/hp/yzg/e-index.html
Birthday
Last Updated :2019/10/12

Researcher Profile and Settings

Profile & Settings

    profile:Research activities focused on biopharmaceutics (drug disposition studies)
    (1) Pharmacokinetic, physiological, and pathophysiological roles of transporters
    (2) Methodologies of evaluation and prediction of drug disposition

Education

  •   1985  - 1986 , The University of Tokyo, Graduate School of Pharmaceutical Sciences, Ph.D. Course
  •   1983  - 1985 , The University of Tokyo, Graduate School of Pharmaceutical Sciences, M.S. Course (completed)
  •   1979  - 1983 , The University of Tokyo, Faculty of Pharmaceutical Sciences (completed)

Degree

  • Ph.D., The University of Tokyo

Association Memberships

  • Pharmaceutical Society of Japan
  • Academy of Pharmaceutical Science and Technology, Japan
  • Japanese Society for the Study of Xenobiotics
  • American Association of Pharmaceutifical Scientists
  • American Society for Pharmacology and Experimental Therapeutics
  • Controlled Release Society
  • International Pharmaceutical Federation
  • International Society for the Study of Xenobiotics

Academic & Professional Experience

  •   2002  - 現在, Nagoya City University, Graduate School of Pharmaceutical Sciences, Professor
  •   2000  - 2002 , Nagoya City University, Faculty of Pharmaceutical Sciences, Professor
  •   1992  - 2000 , Nagoya City University, Faculty of Pharmaceutical Sciences, Associate Professor
  •   1991  - 1992 , Nagoya City University, Faculty of Pharmaceutical Sciences, Senior Assistant Professor
  •   1989  - 1991 , The University of Michigan, College of Pharmacy, Postdoctoral Fellow
  •   1986  - 1991 , Nagoya City University, Faculty of Pharmaceutical Sciences, Assistant Professor

Research Activities

Research Areas

  • Pharmacy, Medical pharmacy, Biopharmaceutics (drug diposition studies)

Research Interests

    transporter, drug disposition, drug development, drug therapy

Published Papers

  • Urate transport function of rat sodium-dependent nucleobase transporter 1., Yasujima T, Murata C, Mimura Y, Murata T, Ohkubo M, Ohta K, Inoue K, Yuasa H, Physiological reports, 6, (10) , Refereed
  • Organic anion transporter 1 (OAT1/SLC22A6) enhances bioluminescence based on d-luciferin-luciferase reaction in living cells by facilitating the intracellular accumulation of d-luciferin., Furuya T, Takehara I, Shimura A, Kishimoto H, Yasujima T, Ohta K, Shirasaka Y, Yuasa H, Inoue K, Biochemical and biophysical research communications, 495, (3) 2152 - 2157, Refereed
  • Specific inhibitory effects of myricetin on human proton-coupled folate transporter: Comparison with its effects on rat proton-coupled folate transporter and human riboflavin transporter 3., Yamashiro T, Yasujima T, Ohta K, Inoue K, Yuasa H, Drug metabolism and pharmacokinetics, 32, (6) 311 - 314, Refereed
  • Functional Identification of Plasma Membrane Monoamine Transporter (PMAT/SLC29A4) as an Atenolol Transporter Sensitive to Flavonoids Contained in Apple Juice., Mimura Y, Yasujima T, Ohta K, Inoue K, Yuasa H, Journal of pharmaceutical sciences, 106, (9) 2592 - 2598, Refereed
  • GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes., Nakayama A, Nakaoka H, Yamamoto K, Sakiyama M, Shaukat A, Toyoda Y, Okada Y, Kamatani Y, Nakamura T, Takada T, Inoue K, Yasujima T, Yuasa H, Shirahama Y, Nakashima H, Shimizu S, Higashino T, Kawamura Y, Ogata H, Kawaguchi M, Ohkawa Y, Danjoh I, Tokumasu A, Ooyama K, Ito T, Kondo T, Wakai K, Stiburkova B, Pavelka K, Stamp LK, Dalbeth N, Eurogout Consortium., Sakurai Y, Suzuki H, Hosoyamada M, Fujimori S, Yokoo T, Hosoya T, Inoue I, Takahashi A, Kubo M, Ooyama H, Shimizu T, Ichida K, Shinomiya N, Merriman TR, Matsuo H, Eurogout Consortium., Annals of the rheumatic diseases, 76, (5) 869 - 877, Refereed
  • Role of Equilibrative Nucleobase Transporter 1/SLC43A3 as a Ganciclovir Transporter in the Induction of Cytotoxic Effect of Ganciclovir in a Suicide Gene Therapy with Herpes Simplex Virus Thymidine Kinase., Furukawa J, Inoue K, Ohta K, Yasujima T, Mimura Y, Yuasa H, The Journal of pharmacology and experimental therapeutics, 360, (1) 59 - 68, Refereed
  • Characteristic Analysis of Intestinal Transport in Enterocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells., Kodama N, Iwao T, Katano T, Ohta K, Yuasa H, Matsunaga T, Drug metabolism and disposition: the biological fate of chemicals, 44, (10) 1662 - 1667, Refereed
  • Kinetic and time-dependent features of sustained inhibitory effect of myricetin on folate transport by proton-coupled folate transporter., Yamashiro T, Ohta K, Inoue K, Furumiya M, Hayashi Y, Yuasa H, Drug metabolism and pharmacokinetics, 30, (5) 341 - 346, Refereed
  • Functional identification of SLC43A3 as an equilibrative nucleobase transporter involved in purine salvage in mammals., Furukawa J, Inoue K, Maeda J, Yasujima T, Ohta K, Kanai Y, Takada T, Matsuo H, Yuasa H, Scientific reports, 5, Refereed
  • Functional identification of organic cation transporter 1 as an atenolol transporter sensitive to flavonoids., Mimura Y, Yasujima T, Ohta K, Inoue K, Yuasa H, Biochemistry and biophysics reports, 2, 166 - 171, Refereed
  • Sustained inhibition of proton-coupled folate transporter by myricetin., Furumiya M, Yamashiro T, Inoue K, Nishijima C, Ohta K, Hayashi Y, Yuasa H, Drug metabolism and pharmacokinetics, 30, (2) 154 - 159, Refereed
  • Molecular identification and functional characterization of the human colonic thiamine pyrophosphate transporter., Nabokina SM, Inoue K, Subramanian VS, Valle JE, Yuasa H, Said HM, The Journal of biological chemistry, 289, (7) 4405 - 4416, Refereed
  • Molecular basis for pharmacokinetics and pharmacodynamics of methotrexate in rheumatoid arthritis therapy., Inoue K, Yuasa H, Drug metabolism and pharmacokinetics, 29, (1) 12 - 19, Refereed
  • Functional characteristics of aquaporin 7 as a facilitative glycerol carrier., Katano T, Ito Y, Ohta K, Yasujima T, Inoue K, Yuasa H, Drug metabolism and pharmacokinetics, 29, (3) 244 - 248, Refereed
  • Noncompetitive inhibition of proton-coupled folate transporter by myricetin., Furumiya M, Inoue K, Nishijima C, Yamashiro T, Inaoka E, Ohta K, Hayashi Y, Yuasa H, Drug metabolism and pharmacokinetics, 29, (4) 312 - 316, Refereed
  • Competitive inhibition of AQP7-mediated glycerol transport by glycerol derivatives., Katano T, Ito Y, Ohta K, Yasujima T, Inoue K, Yuasa H, Drug metabolism and pharmacokinetics, 29, (4) 348 - 351, Refereed
  • Transcriptional regulation of PCFT by KLF4, HNF4α, CDX2 and C/EBPα: implication in its site-specific expression in the small intestine., Furumiya M, Inoue K, Ohta K, Hayashi Y, Yuasa H, Biochemical and biophysical research communications, 431, (2) 158 - 163, Refereed
  • Nicotinate uptake by two kinetically distinct Na÷-dependent carrier-mediated transport systems in the rat small intestine., Ohkubo M, Ohta K, Inoue K, Yuasa H, Drug metabolism and pharmacokinetics, 27, (2) 255 - 262, Refereed
  • Characterization of human OCT1-mediated transport of DAPI as a fluorescent probe substrate., Yasujima T, Ohta K, Inoue K, Yuasa H, Journal of pharmaceutical sciences, 100, (9) 4006 - 4012, Refereed
  • Dual functional characteristic of human aquaporin 10 for solute transport., Ishii M, Ohta K, Katano T, Urano K, Watanabe J, Miyamoto A, Inoue K, Yuasa H, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 27, (6) 749 - 756, Refereed
  • Functional characteristics of the human ortholog of riboflavin transporter 2 and riboflavin-responsive expression of its rat ortholog in the small intestine indicate its involvement in riboflavin absorption., Fujimura M, Yamamoto S, Murata T, Yasujima T, Inoue K, Ohta KY, Yuasa H, The Journal of nutrition, 140, (10) 1722 - 1727, Refereed
  • Evaluation of 4',6-diamidino-2-phenylindole as a fluorescent probe substrate for rapid assays of the functionality of human multidrug and toxin extrusion proteins., Yasujima T, Ohta KY, Inoue K, Ishimaru M, Yuasa H, Drug metabolism and disposition: the biological fate of chemicals, 38, (4) 715 - 721, Refereed
  • Identification and functional characterization of the first nucleobase transporter in mammals: implication in the species difference in the intestinal absorption mechanism of nucleobases and their analogs between higher primates and other mammals., Yamamoto S, Inoue K, Murata T, Kamigaso S, Yasujima T, Maeda JY, Yoshida Y, Ohta KY, Yuasa H, The Journal of biological chemistry, 285, (9) 6522 - 6531, Refereed
  • Molecular and functional characteristics of proton-coupled folate transporter., Yuasa H, Inoue K, Hayashi Y, Journal of pharmaceutical sciences, 98, (5) 1608 - 1616, Refereed
  • Identification and functional characterization of rat riboflavin transporter 2., Yamamoto S, Inoue K, Ohta KY, Fukatsu R, Maeda JY, Yoshida Y, Yuasa H, Journal of biochemistry, 145, (4) 437 - 443, Refereed
  • Functional characterization of multidrug and toxin extrusion protein 1 as a facilitative transporter for fluoroquinolones., Ohta KY, Imamura Y, Okudaira N, Atsumi R, Inoue K, Yuasa H, The Journal of pharmacology and experimental therapeutics, 328, (2) 628 - 634, Refereed
  • Functional characteristics of two human MATE transporters: kinetics of cimetidine transport and profiles of inhibition by various compounds., Ohta KY, Inoue K, Yasujima T, Ishimaru M, Yuasa H, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, 12, (3) 388 - 396, Refereed
  • Functional characterization of PCFT/HCP1 as the molecular entity of the carrier-mediated intestinal folate transport system in the rat model., Inoue K, Nakai Y, Ueda S, Kamigaso S, Ohta KY, Hatakeyama M, Hayashi Y, Otagiri M, Yuasa H, American journal of physiology. Gastrointestinal and liver physiology, 294, (3) G660 - G668, Refereed
  • Effect of glycerol-related compounds on carrier-mediated glycerol uptake in HCT-15 human colon cancer cell line., Fujimoto N, Inoue K, Hayashi Y, Yuasa H, Drug metabolism and pharmacokinetics, 23, (3) 216 - 220, Refereed
  • Functional characterization of human aquaporin 9 as a facilitative glycerol carrier., Ohgusu Y, Ohta KY, Ishii M, Katano T, Urano K, Watanabe J, Inoue K, Yuasa H, Drug metabolism and pharmacokinetics, 23, (4) 279 - 284, Refereed
  • Functional characterization of human proton-coupled folate transporter/heme carrier protein 1 heterologously expressed in mammalian cells as a folate transporter., Nakai Y, Inoue K, Abe N, Hatakeyama M, Ohta KY, Otagiri M, Hayashi Y, Yuasa H, The Journal of pharmacology and experimental therapeutics, 322, (2) 469 - 476, Refereed
  • Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney., Ohta KY, Inoue K, Hayashi Y, Yuasa H, Drug metabolism and disposition: the biological fate of chemicals, 34, (11) 1868 - 1874, Refereed

Misc

  • 【ビタミン この古くて新しき世界】 水溶性ビタミン類の腸管吸収に関わるトランスポーター群, 湯浅 博昭, ファルマシア, 51, (3) 201 - 205,   2015 03
  • 【トランスポーターと疾患研究の最前線】 薬剤応答性とトランスポーター メトトレキサートによる関節リウマチ治療と葉酸トランスポーター, 井上 勝央, 湯浅 博昭, 医学のあゆみ, 245, (1) 127 - 132,   2013 04
  • 【消化管の輸送体】 核酸輸送体, 井上 勝央, 湯浅 博昭, G.I.Research, 19, (5) 426 - 432,   2011 10
  • 【ビタミン・バイオファクターのトランスポーター】 PCFT/SLC46A1による葉酸の吸収機構, 井上 勝央, 湯浅 博昭, ビタミン, 84, (10) 472 - 479,   2010 10
  • アドメノート 薬物体内動態に関わるトランスポーターと臨床的諸問題(第1回) トランスポーター研究の動向2010, 湯浅 博昭, Drug Metabolism and Pharmacokinetics, 25, (4) 6 - 11,   2010 08
  • 【薬物投与の基礎と臨床】 薬物の腸管吸収におけるトランスポーターの役割 ペプチドトランスポーターによるβ-ラクタム系抗生物質の吸収を中心として, 湯浅 博昭, 医学のあゆみ, 197, (1) 3 - 7,   2001 04

Books etc

  • Drug absorption from the colon in situ, Hiroaki Yuasa, "Drug Absorption Studies: In Situ, In Vitro and In Silico Models" ed. by Carsten Ehrhardt and Kwang-Jin Kim, Springer, New York, NY, pp. 77 - 88 (Ch. 3),   2008
  • 消化管吸収の評価法, 湯浅 博昭, 「分子薬物動態学」,杉山 雄一,楠原 洋之編,南山堂,東京,pp. 447 - 459(第24章),   2008
  • 消化管吸収性の予測:in vitroからin vivoへ, 湯浅 博昭, 「薬物バイオアベイラビリティ評価と改善の科学:より良き医薬品開発のために」,杉山 雄一編,現代医療社,東京,pp. 229 - 245(第7章,第1部),   1998
  • 腸管吸収の予測:in vitroからin vivoへ, 湯浅 博昭, 「ファーマコキネティクス研究の方法と技術」,日本薬物動態学会ワークショップ実行委員会編,日本薬物動態学会,東京,pp. 169 - 181(第8章),   1993
  • 薬物生体膜輸送のヒトへの外挿, 湯浅 博昭, 「続医薬品の開発(第4巻):薬物の生体膜輸送と組織標的化II」,寺田 弘,辻 彰編,廣川書店,東京,pp. 518 - 523(第5章,第8節),   1991

Patents

  • 小腸上皮細胞特異的な尿酸トランスポーター及びその利用, 湯浅 博昭, 保嶋 智也, 井上 勝央, 山本 俊輔, 特願2017-152034

Awards & Honors

  •   1995 , Japanese Society for the Study of Xenobiotics, Young Investigator Award
  •   1993 , Pharmaceutical Society of Japan (Tokai Chapter), Young Investigator Award

Research Grants & Projects

  • アクアポリン10の核酸塩基輸送機能:核酸塩基及び関連薬物の小腸吸収における役割, 科学研究費, 基盤研究C,   2013  - 2015 , 湯浅 博昭
  • 樹状細胞に高発現する小胞体膜局在性トランスポーターの機能と免疫系における役割, 科学研究費, 挑戦的萌芽研究,   2011  - 2012 , 湯浅 博昭
  • HCT-15細胞型Na+依存性グリセロールトランスポーターの同定と輸送機能解明, 科学研究費, 基盤研究C,   2008  - 2010 , 湯浅 博昭
  • HCT-15細胞モデルにおけるグリセロールトランスポーターの分子的実体と輸送機能, 科学研究費, 基盤研究C,   2006  - 2007 , 湯浅 博昭
  • 腸管でのグリセロール吸収を担う新規トランスポーターの機能と生理的役割, 科学研究費, 基盤研究C,   2004  - 2005 , 湯浅 博昭
  • 結腸の吸収機能の薬物動態学的及び細胞生物学的解析:経口徐放剤設計の最適化のために, 科学研究費, 基盤研究C,   2000  - 2002 , 湯浅 博昭
  • 経口薬物吸収の生理機構論的解析, 科学研究費, 奨励研究A,   1994  - 1994 , 湯浅 博昭


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