Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
Date (from‐to) : 2019/04 -2022/03
Author : Yasukawa Tsutomu
Intravitreal injections of anti-vascular growth factor drugs, the standard treatment for age-related macular degeneration and other macular diseases, often last for several years, making it difficult for the elderly to continue treatment. As a drug delivery system (DDS) to solve this problem, we are developing a new DDS formulation in which a hollow-core device is filled with lyophilized drug and expansile gas. An acrylic glaucoma implant-type device was implanted in a pigmented rabbit eye, and the released portion was retained intraocularly, showing sustained antibody release over six months. Next, we are developing a encircling buckling-type device used in retinal detachment surgery, because larger inner volume is available for DDS. Teflon was hard and silicone had high gas permeability. Other material will be sought.