MF Researcher Database

Researchers Database

Advance

KAZIKURI Zyunko

    Graduate School of Medical Sciences Department of Pharmacology　Assistant Professor
Last Updated :2025/12/23

Researcher Information

J-Global ID

Published Papers

MISC

Research Grants & Projects

  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2024/04 -2027/03 
    Author : 梶栗 潤子; 大矢 進
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2024/04 -2027/03 
    Author : 大矢 進; 梶栗 潤子; 鬼頭 宏彰
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2014/04 -2017/03 
    Author : Kikuchi Chigusa
     
    In this study, we examined vascular endothelium function using diabetes model animals and questionnaire on factors of going for a medical checkup for women to clarify the mechanism of vascular endothelium dysfunction mediated by sex difference. In diabetes model female rats, post-occlusive hind limb reactive hyperemia index was decreased as compared with control rats at early stage. As the result of the questionnaire, many women were under stress. It was suggested that especially child rearing and economic factors prevent women from going for a medical checkup.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2013/04 -2017/03 
    Author : ITOH Takeo; OTSUKA Ryo
     
    Significant intimal hyperplasia was formed with loss of functions of both endothelium-derived nitric oxide (EDNO) and endothelium-derived hyperpolarizing factor (EDHF) in rabbit autologous jugular vein graft under poor distal runoff. Ezetimibe (a selective cholesterol transport inhibitor) and vildagliptin (a dipeptidyl peptidase-4 inhibitor) each in part recovered the function of EDNO (but not EDHF) and reduced intimal hyperplasia. In contrast, in rabbit autogenous carotid artery graft model, receptor-mediated, endothelium-dependent relaxation was enhanced by increased function of EDNO (but not of EDHF). The intimal thickening was minimal, suggesting that better patency of autogenous arterial graft is considered when compared with that of vein graft in aortocoronary revascularization. These results suggest that upregulation of the EDNO function could be beneficial in reducing intimal hyperplasia in both artery graft and vein graft.
  • Japan Society for the Promotion of Science：Grants-in-Aid for Scientific Research
    Date (from‐to) : 2011 -2013 
    Author : KIKUCHI CHIGUSA; MATSUNAGA Tamihide; IMAEDA Kenro; SUZUKI Tadashi; KAJIKURI Jyunko
     
    In this study, we examined the mechanism of vascular dysfunction mediated by postprandial hyperglycemia and the effects of new antidiabetes agent, dipeptidyl peptidase 4 (DPP-4) inhibitor using model animals and patient's data. Onset of atherosclerotic disease in diabetic patients was depend on circadian rhythm of blood glucose. Protein kinase C delta was decreased and reactive oxygen species via eNOS uncoupling was increased in the vascular wall of postprandial hyperglycemia model animals. Chronic administration of DPP-4 inhibitor suppresses postprandial hyperglycemia and decreased reactive oxygen species production.

Other link

researchmap


Copyright © MEDIA FUSION Co.,Ltd. All rights reserved.