Researchers Database

KAWASHIMA Shoji

    Graduate School of Medical Sciences Department of Neurology Assistant Professor
Last Updated :2024/04/24

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  • Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research Grant-in-Aid for Young Scientists (B)
    Date (from‐to) : 2015/04 -2018/03 
    Author : Shoji Kawashima; Shimizu Yoko; Horiba Hiroya
     
    Cognitive impairment is a common symptom in Parkinson's disease (PD). Mild cognitive impairment (MCI) is a transitional stage between normal aging and dementia. We investigate the association of neuropsychological and imaging findings (fMRI), comparing patients with cognitive normal (PD-CN) and PD-MCI. We recruited 28 non-demented PD patients (15 patients were PD-CN, 13 were PD-MCI). The activations within the Inferior Parietal Lobule and Rt. Middle Frontal Gyrus were decreased in association with the demand of visuospatial working memory in PD-MCI. The function of these regions may have a potential to evaluate the increased risk of dementia in PD. From analysis between Memantine intervention and Placebo, memantine reduce the functional brain activity within caudate and superior frontal gyrus. Memantine is not benefical for the stage of PD-MCI.


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