Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2018/04 -2021/03
Author : Kato Junko
Although the number of obese people are on the rise due to the Westernization of dietary habits worldwide, many people are also known to follow diet plans. Out of all the diet booms in recent years, low-carbohydrate diet (LCD) has been the most prevalent. We investigated the influence of low-carbohydrate diet on erectile function using animal model.
We divided 12-week-old male Wistar-ST rats into control and LCD groups. After 4 weeks, we measured erectile function of rats. This study suggests that extreme carbohydrate restriction reduces erectile function. In addition, when the relaxation reaction due to transwall electrical stimulation was measured by isometric tension measurement, a significant decrease in the response was observed in the LCD group. In addition, when the expression fluctuation of neural nitric oxide synthase (nNOS) in the corpus cavernosum was examined using real-time PCR, a significant decrease was observed in the LCD group.