Japan Society for the Promotion of Science:Grants-in-Aid for Scientific Research
Date (from‐to) : 2002 -2004
Author : MOTOKI Tanikawa; YAMADA Kazuo; MASE Mitsuhito; AIHARA Noritaka; YAMAMOTO Kenichi
Recent evidence has suggested apoptosis as an important component of degenerative processes after spinal cord injury (SCI). We tried to confirm this relationship, and to apply the hypothermia therapy, that included systemic method by using specific blanket, and local method by intrathecal-administration of cold saline. However, we could not get any significant results from each experiment, because it might be difficult to keep body temperature of rats for a certain period. We tried to improve those methods, yet we could not do that in this term.. On the other hand, we clarified that expressions of SMIT and myelincephalon specific protease (MSP) increased around injured site. Those molecules might be related to apoptosis and secondary injury of neuronal tissue. We think that there will be some possibility for neuronal protection from secondary injury by further experiments, such as inhibition of functions of those molecules